Takahiro Hosokawa, Yoshitake Yamada, Mayumi Hsokawa, Shunsuke Kikuchi, Kenji Ohira, Yutaka Tanami, Yumiko Sato, Eiji Oguma,
Tópico(s): Intestinal Malrotation and Obstruction Disorders
2018 - Springer Science+Business Media | Japanese Journal of Radiology
Hiroyuki Nakamura, Shunsuke Kikuchi, Kazuki Kawai, Satomu Ishii, Shinichi Sato,
Abstract Maleimide-functionalized closo -dodecaborate (MID) and isothiocyanate-functionalized closo -dodecaborate (ISD) were synthesized from closo -dodecaborate via ring opening reaction of 1,4-dioxane- closo -dedecaborate complex 1 with ammonia. MID was found to possess highest conjugation efficacy to bovine serum albumin among three closo -dodecaborate derivatives, MID, ISD, and 1 . The conjugation reaction of MID to human serum albumin (HSA) proceeded under PBS buffer conditions (pH 7.4). Boron distribution ...
Tópico(s): Nanoparticle-Based Drug Delivery
2018 - International Union of Pure and Applied Chemistry | Pure and Applied Chemistry
Shunsuke Kikuchi, Daisuke Kanoh, Shinichi Sato, Yoshinori Sakurai, Minoru Suzuki, Hiroyuki Nakamura,
Maleimide-conjugating closo-dodecaborate sodium form 5c (MID) synthesized by the nucleophilic ring-opening reaction of closo-dodecaborate-1,4-dioxane complex 2 with tetrabutylammonium (TBA) azide was found to conjugate to free SH of cysteine and lysine residues in BSA under physiological conditions, forming highly boronated BSA that showed high and selective accumulation in tumor and significant tumor growth inhibition in colon 26 tumor-bearing mice subjected to thermal neutron irradiation.
Tópico(s): Medical Imaging Techniques and Applications
2016 - Elsevier BV | Journal of Controlled Release
Yoshihiro Natori, Shunsuke Kikuchi, Takahiro Kondo, Yukako Saito, Yuichi Yoshimura, Hiroki Takahata,
Intramolecular iridium-catalyzed allylic aminations of homochiral (E)-6-N-nosylaminohept-2-en-1-yl methyl carbonates were investigated. The relative position of the 2,5-substituents of the resulting pyrrolidines was found to be controlled by using both enantiomers (4 and 5) of the appropriate chiral ligand, demonstrating a simple and highly stereodivergent synthetic protocol. Selected trans- and cis-2,5-disubstituted 3-hydroxypyrrolidines (2a and 18a) were converted to (+)-bulgecinine (6) and (+)-preussin (7), ...
Tópico(s): Asymmetric Hydrogenation and Catalysis
2014 - Royal Society of Chemistry | Organic & Biomolecular Chemistry
Shunsuke Kikuchi, Katsuhiro Mikami, Daisuke Nakashima, Toshiyuki Kitamura, Noboru Hasegawa, Masaharu Nishikino, Arihiko Kanaji, Masaya Nakamura, Takeo Nagura,
Artificial joint acetabular cup stability is essential for successful total hip arthroplasty. However, a quantitative evaluation approach for clinical use is lacking. We developed a resonance frequency analysis (RFA) system involving a laser system that is fully contactless. This study aimed to investigate the usefulness of laser RFA for evaluating acetabular cup stability. First, the finite element method was performed to determine the vibration mode for analysis. Second, the acetabular cup was ...
Tópico(s): Orthopedic Infections and Treatments
2019 - Multidisciplinary Digital Publishing Institute | Sensors
Daisuke Nakashima, Katsuhiro Mikami, Shunsuke Kikuchi, Masaharu Nishikino, Toshiyuki Kitamura, Noboru Hasegawa, Morio Matsumoto, Masaya Nakamura, Takeo Nagura,
There is no evaluation method currently available to assess intraoperative pedicle screw fixation (PSF) strength. In this study, we established a laser-based resonance frequency analysis (RFA) system with high-speed, noncontact, quantitative measurements of PSF. Clinical investigations in the future can assess surgical failure risk of implants. We investigated the characteristics of the laser RFA and compared them with the conventional methods. We inserted a pedicle screw in the vertebral pedicle ...
Tópico(s): Medical Imaging and Analysis
2021 - Wiley | Journal of Orthopaedic Research®
Jonas A. PRAMUDITA, Shunsuke Kikuchi, Izumi Minato, Yuji TANABE,
Many neck safety technologies have been developed in recent years; however, the incidence of whiplash-associated disorders (WAD) in rear-end collision accidents remains high. A lack of consideration of individual differences among vehicle occupants is considered a major factor. Individual differences in the neck can be represented by the differences in cervical spine alignment. In this study, images of typical cervical spine alignments, such as lordotic, straight, kyphotic, s-shaped, and inverse ...
Tópico(s): Spinal Fractures and Fixation Techniques
2017 - Taylor & Francis | International Journal of Crashworthiness
Hiroki Takahata, Yoshihiro Natori, Shunsuke Kikuchi, Yuichi Yoshimura, Atsushi Kato, Isao Adachi,
An asymmetric synthesis of 1-alkyl-2-deoxyiminofuranoses was achieved in which the Ir-catalyzed intramolecular cyclization was the key step.The diastereoselective cyclization converted an allylic carbonate into pyrrolidine derivatives.The !-glucosidase inhibitory activities of the prepared 2-deoxyiminofuranoses were also investigated.
Tópico(s): Asymmetric Synthesis and Catalysis
2012 - Elsevier BV | Heterocycles
Tsukasa Saida, Kensaku Mori, Yumiko Tanaka, Masafumi Sakai, Taishi Amano, Shunsuke Kikuchi, Souta Masuoka, Miki Yoshida, T. Masumoto, Toyomi Satoh, Manabu Minami,
Tópico(s): Endometrial and Cervical Cancer Treatments
2020 - Springer Science+Business Media | Japanese Journal of Radiology
Yasuhiro Shirakawa, Kazuhiro Noma, Naoaki Maeda, Takayuki Ninomiya, Shunsuke Tanabe, Satoru Kikuchi, Shinji Kuroda, Masahiko Nishizaki, Shunsuke Kagawa, Yoshiro Kawahara, Hiroyuki Okada, Toshiyoshi Fujiwara,
Tópico(s): Metastasis and carcinoma case studies
2018 - Springer Science+Business Media | Esophagus
Shunsuke Yoshimine, Eiji Kikuchi, Takeo Kosaka, Shuji Mikami, Akira Miyajima, Yasunori Okada, Mototsugu Oya,
Bcl-xL has an important role in the control of cell death through its inhibition of apoptosis. The aim of this study was to investigate the clinicopathological significance of Bcl-xL in upper urinary tract urothelial carcinoma (UTUC) and the therapeutic effect of targeting Bcl-xL protein in urothelial carcinoma (UC) cells.We evaluated the immunohistochemical expression of Bcl-xL in 175 UTUC patients to determine the clinical role of Bcl-xL expression in clinical outcome. We used bafilomycin A1 (BMA) ...
Tópico(s): Urinary and Genital Oncology Studies
2013 - Springer Nature | British Journal of Cancer
Shunsuke Tamaru, Akihiko Kikuchi, Kimiyo Takagi, Masao Wakamatsu, Kyoko Ono, Tsuguhiro Horikoshi, Hideki Kihara, Tomohiko Nakamura,
Very premature infants occasionally have neurodevelopmental disabilities. However, there have been quite limited data on prenatal risk factors associated with their neurodevelopmental outcomes.To clarify the relationship between prenatal risk factors and neurodevelopmental outcomes of very premature infants.The study design is a retrospective review.One hundred seventy Japanese women with a singleton pregnancy and their infants whose birth weight being less than 1500 g were included. We classified ...
Tópico(s): Neonatal and fetal brain pathology
2010 - Elsevier BV | Early Human Development
Shunsuke Yoshimine, Eiji Kikuchi, Kazuhiro Matsumoto, Hiroki Ide, Akira Miyajima, Ken Nakagawa, Mototsugu Oya,
To evaluate the impact of urine cytology on the prediction of the upper urinary tract recurrence (UTR) of urothelial cancer after a radical cystectomy (RC) with urinary diversion.A total of 125 patients who underwent RC from 1987 to 2005 were retrospectively identified. The median follow-up period was 64 months. The specimens for urine cytology were obtained from the urine voided or obtained through a catheter or a conduit. The relationship between a positive urine cytology result and UTR detection ...
Tópico(s): Urological Disorders and Treatments
2010 - Wiley | International Journal of Urology
Shunsuke Tamaru, Akihiko Kikuchi, Kyoko Ono, Mariko Kita, Tsuguhiro Horikoshi, Kimiyo Takagi,
Abstract Prenatal diagnosis of a congenital ranula has rarely been reported. We describe the case of a small ranula depicted on prenatal sonogram and magnetic resonance imaging, in which we could confirm the intact airway. Although the size of the ranula noted in our fetus was the smallest among the cases reported in the English literature, both of these imaging modalities clearly presented typical diagnostic features present on both ultrasound and magnetic resonance imaging. © 2009 Wiley Periodicals, ...
Tópico(s): Teratomas and Epidermoid Cysts
2009 - Wiley | Journal of Clinical Ultrasound
Nanae Izumi, Katsumi Fumoto, Shunsuke Izumi, Akira Kikuchi,
Glycogen synthase kinase-3β (GSK-3β) is known to play a role in the regulation of the dynamics of microtubule networks in cells. Here we show the role of GSK-3β in the proper formation of the mitotic spindles through an interaction with GCP5, a component of the γ-tubulin ring complex (γTuRC). GCP5 bound directly to GSK-3β in vitro, and their interaction was also observed in intact cells at endogenous levels. Depletion of GCP5 dramatically reduced the GCP2 and γ-tubulin in the γTuRC fraction of sucrose ...
Tópico(s): Wnt/β-catenin signaling in development and cancer
2008 - Elsevier BV | Journal of Biological Chemistry
Manabu Kurayoshi, Hideki Yamamoto, Shunsuke Izumi, Akira Kikuchi,
Wnt-5a is a representative ligand that activates a β-catenin-independent pathway in Wnt signalling. In the present paper, the roles of the post-translational modifications in the actions of Wnt-5a were investigated. We found that Wnt-5a is modified with palmitate at Cys104 and glycans at Asn114, Asn120, Asn311 and Asn325. The palmitoylation was not essential for the secretion of Wnt-5a, but was necessary for its ability to suppress Wnt-3a-dependent T-cell factor transcriptional activity and to stimulate ...
Tópico(s): Peptidase Inhibition and Analysis
2007 - Portland Press | Biochemical Journal
Jumpei Kamimura, Tetsuya Kouno, Shunsuke Ishizawa, Akihiko Kikuchi, Katsumi Kishino,
InxAl1−xN nanocolumns (xIn=0.73–1.00) of c-axis orientation were successfully self-organized on Si (1 1 1) substrates by RF-plasma-assisted molecular-beam epitaxy (RF-MBE). The height, diameter and density of nanocolumns were 0.7–1.1 μm, 40–130 nm, and 0.7–3.0×1010 cm−2, respectively. With increasing In composition from 0.73 to 1.00, the room-temperature photoluminescence (RT-PL) peak wavelengths shifted from 1.06 to 1.87 μm. AlN nanocolumns (when xIn=0) were also fabricated, and RT-PL was observed with ...
Tópico(s): Ga2O3 and related materials
2007 - Elsevier BV | Journal of Crystal Growth
Tatsuya Takeguchi, Shunsuke Manabe, Ryuji Kikuchi, Koichi Eguchi, Takaaki Kanazawa, Shinichi Matsumoto, Wataru Ueda,
Precious metal (PM) dispersions on CeO2-containing supports were examined. When dispersions were evaluated by the H2–O2 titration method, the CeO2-containing supports hide the true redox of PM because of the large oxygen storage-reduction capacity of the oxide, resulting in higher apparent dispersions than the exact values. When Pt dispersions on the CeO2 support were evaluated by the ordinary CO pulse method, CO was adsorbed on the CeO2 support as carbonate species accompanying the oxidation with ...
Tópico(s): Luminescence Properties of Advanced Materials
2005 - Elsevier BV | Applied Catalysis A General
T. Aoki, Takayoshi Koike, Toru Nakano, Kei‐ichi Shibahara, Shunsuke Kondo, H Kikuchi, Tasuku Honjo,
We have found that expression of the Bip (immunoglobulin heavy chain binding protein)/ GRP78 (glucose regulated protein 78) gene is markedly enhanced specifically among the heat shock protein (HSP) 70 gene family during the neuronal cell death of PC12 (22a) cells, that is induced by removal of nerve growth factor (NGF) and blocked by a transcription inhibitor, actinomycin D. The Bip mRNA induction is suppressed when the NGF-deprivation-dependent cell death of PC12 (22a) cells is inhibited by cAMP, cycloheximide ...
Tópico(s): Cell death mechanisms and regulation
1997 - Oxford University Press | The Journal of Biochemistry
Shunsuke Uchida, Makoto Kikuchi, Yamato ASAKURA, Hideo Yusa, Katsumi Ohsumi,
A calculation model was developed to predict the shutdown dose rate around the recirculation pipes and their components in boiling water reactors (BWRs) by simulating the corrosion product transport in primary cooling water. The model is characterized by separating cobalt species in the water into soluble and insoluble materials and then calculating each concentration using the following considerations: 1. Insoluble cobalt (designated as crud cobalt) is deposited directly on the fuel surface, while ...
Tópico(s): Nuclear Engineering Thermal-Hydraulics
1978 - Taylor & Francis | Nuclear Science and Engineering
Shunsuke Kobayashi, Kôichi Kikuchi, Hiroshi Kokubun,
Tópico(s): Spectroscopy and Quantum Chemical Studies
1978 - Elsevier BV | Chemical Physics
Shunsuke Kobayashi, Kôichi Kikuchi, Hiroshi Kokubun,
Tópico(s): Spectroscopy and Quantum Chemical Studies
1976 - Elsevier BV | Chemical Physics Letters
Masami Aono, Shunsuke Kikuchi, Naoyuki Tamura, Nobuaki Kitazawa, Yoshihisa Watanabe, Shugo Nitta,
Abstract Columnar structured amorphous carbon nitride films were deposited by reactive radio frequency magnetron sputtering from a graphite target in glow discharge plasma of nitrogen. The columnar structure was observed in all specimens of the amorphous carbon nitride (a‐CN x ) films deposited on substrates of crystalline Si and quartz glass within substrate temperatures between RT and 853 K in nitrogen gas pressure of 0.12 to 0.8 Torr. The average diameter of the columns obtained from SEM was found ...
Tópico(s): Plasma Diagnostics and Applications
2010 - Wiley | Physica status solidi. C, Conferences and critical reviews/Physica status solidi. C, Current topics in solid state physics
Yasuhiro Shirakawa, Hiroshi Tazawa, Shunsuke Tanabe, Nobuhiko Kanaya, Kazuhiro Noma, Takeshi Koujima, Hajime Kashima, Takuya Kato, Shinji Kuroda, Satoru Kikuchi, Shunsuke Kagawa, Kuniaki Katsui, Susumu Kanazawa, Yasuo Urata, Toshiyoshi Fujiwara,
Purpose OBP-301 (Telomelysin) is an attenuated type-5 adenovirus that contains the human telomerase reverse transcriptase promoter to regulate viral replication. OBP-301 sensitises human cancer cells to ionising radiation by inhibiting DNA repair, and radiation enhances coxsackievirus and adenovirus receptor–mediated OBP-301 infection on the contrary. We assessed OBP-301 with radiotherapy in oesophageal cancer patients unfit for standard chemoradiation treatments. Methods A phase I dose-escalation ...
Tópico(s): CAR-T cell therapy research
2021 - Elsevier BV | European Journal of Cancer
Shunsuke Tamaru, Akihiko Kikuchi, Kimiyo Takagi, Jiu Okuno, Kaori Ishikawa, Shinya Imada, Tsuguhiro Horikoshi, Yu‐ichi Goto, Shinichi Hirabayashi,
Abstract Prenatal depiction of brain dysgenesis in patients with pyruvate dehydrogenase complex (PDHc) deficiencies has been infrequently reported. As PDHc plays a critical role in the brain that obtains all of the energy from the aerobic oxidation of glucose, its deficiency is a severe inborn disorder of metabolism, which predominantly affects the nervous system. This report describes a case of PDHc deficiency with antenatal brain dysgenesis depicted in detail by fetal ultrasound and magnetic resonance ...
Tópico(s): Diet and metabolism studies
2011 - Wiley | Journal of Clinical Ultrasound
Norio Hanafusa, Masanori Abe, Nobuhiko Joki, Junichi Hoshino, Kan Kikuchi, Shunsuke Goto, Eiichiro Kanda, Masatomo Taniguchi, Shigeru Nakai, Toshihide Naganuma, Takeshi Hasegawa, Kenichiro Miura, Atsushi Wada, Yoshiaki Takemoto, Kazuyuki Maeno, Chikara Oyama, Koji Seino, Toshinobu Sato, Shigeru Sato, Minoru Ito, Junichiro James Kazama, Atsushi Ueda, Osamu Saitô, Tetsuo Ando, Tomonari Ogawa, Hiroo Kumagai, Hiroyuki Terawaki, Kôichi Hayashi, Ryoichi Ando, Mas anori Abe, Tetsuya Kashiwagi, Chieko Hamada, Yugo Shibagaki, Nobuhito Hirawa, Hisaki Shimada, Yoichi Ishida, Hitoshi Yokoyama, Ryoichi Miyazaki, Mizuya Fukasawa, Yuji Kamijyo, Teppei Matsuoka, Akihiko Kato, Noriko Mori, Yasuhiko Ito, Hirotake Kasuga, Sukenari Koyabu, Tetsuro Arimura, Tetsuya Hashimoto, Masaaki Inaba, Terumasa Hayashi, Tomoyuki Yamakawa, Shinichi Nishi, Akira Fujimori, Tatsuo Yoneda, Shigeo Negi, Akihisa Nakaoka, Takafumi Ito, Hitoshi Sugiyama, Takao Masaki, Yutaka Nitta, Kazuyoshi Okada, Masahito Yamanaka, Masaharu Kan, Kazumichi Ota, Masahito Tamura, Koji Mitsuiki, Yuji Ikeda, Masaharu Nishikido, Akira Miyata, Tadashi Tomo, Shoichi Fujimoto, Tsuyoshi Nosaki, Yoshinori Oshiro,
Abstract Background The 2020 Japanese Society for Dialysis Therapy Renal Data Registry (JRDR) annual survey was sent to 4493 dialysis facilities in Japan. Methods Questionnaires were sent to all facilities that provide patients with dialysis therapy in Japan. Data were collected and compiled to form cross-sectional results of renal replacement therapy from various aspects. Results In total, 4437 facilities (98.8%) responded to the facility questionnaire and 4271 (95.1%) responded to the patient questionnaire. ...
Tópico(s): Neurological Complications and Syndromes
2024 - BioMed Central | Renal Replacement Therapy
Norio Hanafusa, Masanori Abe, Nobuhiko Joki, Tetsuya Ogawa, Eiichiro Kanda, Kan Kikuchi, Shunsuke Goto, Masatomo Taniguchi, Shigeru Nakai, Toshihide Naganuma, Takeshi Hasegawa, Junichi Hoshino, Kenichiro Miura, Atsushi Wada, Yoshiaki Takemoto,
Abstract Background The Japanese Society for Dialysis Therapy is conducting the survey annually since 1968. The results provide a comprehensive picture of dialysis therapy in Japan. The survey for the year 2019 was performed as of December 2019. Methods Questionnaires were sent to all facilities that provide patients with dialysis therapy in Japan as an Excel file. Data were collected and compiled to form cross-sectional results of dialysis therapy from various aspects. Results At the end of 2019, ...
Tópico(s): Chronic Kidney Disease and Diabetes
2023 - BioMed Central | Renal Replacement Therapy
Kenji Kikuchi, Shunsuke Shigeta, Keiko Numayama‐Tsuruta, Takuji Ishikawa,
Skin barrier function is the battlefront for preventing permeation of harmful substances and infectious diseases. However, it can be destroyed by mechanical forces, as shown in many studies. Excess rubbing may increase the permeability of the skin to aqueous material. Although the skin barrier plays an important physiological role in humans, the vulnerability of skin to mechanical rubbing is poorly understood. Therefore, we investigated the effects of rubbing on the skin in vitro; skin damage was ...
Tópico(s): Bee Products Chemical Analysis
2020 - Elsevier BV | International Journal of Pharmaceutics
Shoichi Kikuchi, Shunsuke Tamai, Takao Kawai, Yoshikazu NAKAI, Hiroki Kurita, Sophie Gourdet,
TiB-reinforced Ti-3Al-2.5V matrix composites, in which TiB whiskers are oriented parallel to the direction of heat extrusion, were fabricated via mechanical alloying and hot isostatic pressing (HIP). To investigate the near-threshold fatigue crack propagation in TiB-reinforced Ti-3Al-2.5V matrix composites, stress intensity factor K-decreasing tests were conducted for disk-shaped compact specimens having two different orientations of TiB whiskers at force ratios from 0.1 to 0.8 under ambient conditions. ...
Tópico(s): Intermetallics and Advanced Alloy Properties
2019 - Multidisciplinary Digital Publishing Institute | Materials
Shinji Kuroda, Yasuhiro Choda, S. Otsuka, Satoshi Ueyama, Norimitsu Tanaka, Atsushi Muraoka, Shinji Hato, Toshikazu Kimura, Kohji Tanakaya, Satoru Kikuchi, Shunsuke Tanabe, Kazuhiro Noma, Masahiko Nishizaki, Shunsuke Kagawa, Yasuhiro Shirakawa, Yasuaki Kamikawa, Toshiyoshi Fujiwara,
Abstract Aim As a result of the difficulty in effective prevention of gastroesophageal reflux, no standard reconstruction procedure after proximal gastrectomy ( PG ) has yet been established. The double‐flap technique ( DFT ), or Kamikawa procedure, is an antireflux reconstruction procedure in esophagogastrostomy. The efficacy of DFT has recently been reported in several studies. However, these were all single‐center studies with a limited number of cases. Methods We conducted a multicenter retrospective ...
Tópico(s): Esophageal Cancer Research and Treatment
2018 - Wiley | Annals of Gastroenterological Surgery