Andrew Robson, Janice Turner, S. B., Pippa Holt, Joanna Hunter, Helen Studd, Catherine Riley, DJM, Jim Blake, Sarah Potter, Simon Barnes, Iain Cassie, Paul Nicholson, Sarah Ewing, Peter Lansley, Mark Souster, Ian Blackshaw, Martin Richards, Richard Hobson, J. B. D, Rog Wright, Ivo Tennant, John Romer, Philip Howard, Carol Midgley, Nic Hopkins, Douglas Hall, David Lister Ireland Correspondent, Roger Maynard, Kevin Eason, James Eve, Geoff Brown, Gerald Davies, Sam Lister, Mark Wilson, Antonia Senior, Neville Scott and Geoffrey Dean, Pat Gibson, David McVay, Donald Hutera, Thrasy Petropoulos, Simon Kuper, Jennai Cox Fitness Editor, Jack Malvern, Dominic Walsh, Charlie Flindt, Shirley English, Caitln Moran, Tim Reid, Ruth Gledhill Religion Correspondent, Ronan McGreevy and Emma Hartley, Phoebe Greenwood, Richard Ford Home Correspondent, Mellssa Kite, Richard Ford and Oliver August, Stephen Farrell, Oliver Wright Health Correspondent, Fabian Caballero, Cluny Mac pherson, Phil Gordon, Richard Lloyd Parry, David Hands, Richard Johnson, Russell Hewitson, P. G. Reasbeck, Stephen Collins, Mark Pougatch, Alister McMillan, Angela Jameson, B. H., Simon Tait, Tony Halpin Education Editor, Daniel McGrory, Oliver Kay, Diana Knight, Peter Ward, John Westerby, Rick Broadbent, Tom Baldwin, Stephen Burgen, Mark Henderson Science Correspondent, Valerie Shrubb, John Hopkins Golf Correspondent, Roger Harrison-Topham, Rob Wright, Geoffrey Dean, Neil Harman Tennis Correspondent, Raymond Keene, Adam Sage, Christine Buckley, Matthew Pryor, Sean MacAulay, Derick Allsop, Christine Buckley Industrial Editor, Geoffrey Hall (Editor), Neville Scott, Angus I. Milne, Chris Campling, Russell Hotten, Cathy Harris, Richard Owen, Damian Whitworth, Martin Woods, Emily Davies, Oliver August, David Hands Rugby Correspondent, Nigel Farage, Tony Cascarino, Tom Dart, Glen Owen, Paul Simons, Michelle Henery, Andrew Clennell, William Rees-Mogg, Nick Szczepanik, James Doran, Melissa Kite Political Correspondent, Tim Hames, Barry Ferguson, Ian Johns, Mel Webb, Ashling O'connor, Richard Heller, Chris McGrath, George Caulkin, Richard Watson, Ingrid Mansell, Michael Austin, Alan Lee, Robert Tait, Walter Gammie, Amy Chew, Michael Dynes, Jack Malvern Arts Reporter, Graham Searjeant, Lewis Stuart, Gary Duncan Economics Correspondent, Esme Poppleton (Part-time law lecturer), Charles Hennessy, Robin Wight, James Jackson, Emma Hartley, Benedict Nightingale, Rob Green, Timothy W. G. Bacon, Jonathan Meades, Stephen Dalton, A. P., Alyson Rudd, Richard Morrison, Bill Edgar, Nigel Bond, Simon Crompton, Mark Venables, Tom Baldwin and Andrew Pierce, Jan Raath, Steve Webb (Liberal Democrat Spokesman for Work and Pensions), Tim Johnston, Edward Gorman Sailing Correspondent, Sandy Gall, Lisa Verrico, Peter Morrogh, Stephen Pollard,
... Point Way for United Italy's Rising Son Shunsuke Nakamura tells James Eve Why his compatriots have a ...
2003 - Gale Group | TDA
Emi Yasuda, Ryuichi Nakamura, Ryo Matsugi, Shinsuke Goto, Yasunori Ikenaga, Kazunari Kuroda, Shunsuke Nakamura, Yasuo Katsuki, Tatsuo Katsuki,
Tópico(s): Inflammatory mediators and NSAID effects
2017 - Springer Science+Business Media | Aging Clinical and Experimental Research
Giles Smith, Andrew Robson, Siobhan kennedy, Andrew Billen, Alexandra Frean, Zahid Hussain, John K. Wales, David Aaronovitch, Frances Gibb Legal Editor, Robert Lindsay, Linda Tsang, David Rose, Denise Iredell, Alexandra Frean Education Editor, Michael Evans Defence Editor, Philip Howard, Katie Scott, Hilary Finch, Grínne Gilmore, Christine Seib, David Chater, James Ducker, Rachel Campbell-Johnston, Penny Wark, Elizabeth Judge, Dr D. Ian McCallum, Gabrielle Starkey, Lucia Van Der Post, Carl Mortished, Robert Corzine, Davy Jones, Will Pavia, Sam Marlowe, Vince Ellis, James Hider, Kevin Eason, Joe Joseph, Andrew Norfolk, Robin Pagnamenta, Sean O'Neill Crime Editor, Mark Barrowcliffe, Valerie Elliott Countryside Editor, Jane MacArtney, Siobhan Kennedy, Tom Bawden, R. A. Graham, Dan Sabbagh Media Editor, Debra Craine, Gary Jacob, Tim Reid, Rosemary Bennett, Jennifer Taylor, Ruth Gledhill Religion Correspondent, Dalya Alberge Arts Correspondent, Dan Sabbagh, Libby Purves, Richard Ford Home Correspondent, Daniel Johnson, David Sharrock Ireland Correspondent, Martin Rogers, Jacqueline Frampton, Charles Bremner, Dominic Carman, Adam Sherwin Media Correspondent, Ruth Homer, Hugo Rifkind, Derwent May, John Gayfer, Ed Potton, Suzy Jagger, Oliver Kay, Edward Fennell, Gerard Baker, Sarah Vine, Mark Henderson Science Editor, Tom Baldwin, James Rossiter, Sam Coates, John Hopkins, Steuart & Francis, Simon de Bruxelles, John Hopkins Golf Correspondent, Rob Wright, Gabriel Rozenberg, Rear-Admiral Roy Clare, Raymond Keene, Sean O'Neill Crime and Security Editor, Matt Dickinson, Matt Hughes, Rebecca O'Connor, Peta Bee, Jeremy Page, Bronwen Maddox, Adam Fresco Crime Correspondent, Jill Sherman, Patrick Hosking, Richard Owen, Tom Perkins, Damian Whitworth, Marcus Leroux, Mick Hume, Glunis Kozma, Roger Boyes, Francis Elliott Deputy Political Editor, Gabriel Rozenberg Economics Reporter, Nick Hasell, David Hands Rugby Correspondent, Owen Slot Chief Sports Reporter, Tom Dart, Paul Simons, Adam Fresco, Charles Caudrelier, Jonathan Clayton, Philip Webster Political Editor, Steve Hawkes, Dominic Maxwell, Alice Fordham, Marc Guillemot, George Caulkin, J. G. Wishart, John Hopewell, Neil Fisher, Alan Lee, Anthony Loyd, Peter Riddell, Michael Gove, Philip Webster, Jamie Whyte, Martin Waller, Chris Ayres, Lisa Verrico, Nigel Hawkes Health Editor, Ashling O'Connor, Val Horsler, Stephen Cragg, Rick Broadbent Athletics Correspondent, Stephen Dalton, Mohamed El Sharkawy, Nicola Woolcock, Alyson Rudd, Bill Edgar, Adam Sherwin, Olav Bjortomt, Nicola Copping, Richard Tripp, Christopher Irvine,
... to 'go for jugular' Celtic will be without Shunsuke Nakamura for their … Liverpool Besiktas Home where the heart ...
2007 - Gale Group | TDA
Norio Goto, Ken Okazaki, Takenori Akiyama, Yukio Akasaki, Hideki Mizu‐uchi, Satoshi Hamai, Shunsuke Nakamura, Yasuharu Nakashima,
Tópico(s): Total Knee Arthroplasty Outcomes
2018 - Springer Science+Business Media | Knee Surgery Sports Traumatology Arthroscopy
Lu Ding, Kunio Yoshikawa, Minoru FUKUHARA, Yuto Kowata, Shunsuke Nakamura, Xin Dai, Muhan Li,
Ultra-small biomass gasification and power generation systems are a promising technology for disaster areas in developed countries and non-electrified rural areas of developing countries. The gasification characteristics of carbonized wood pellets and carbonized wood briquettes without or with 1 wt% sea salt were tested in a pilot-scale updraft fixed-bed gasifier. The results showed that the carbon balance during gasification was easily achieved, and most of the chlorine in the carbonized briquettes ...
Tópico(s): Energy and Environment Impacts
2018 - Elsevier BV | Fuel
Takahiro Yamamoto, Motoki Fujita, Yasutaka Oda, Masaki Todani, Toru Hifumi, Yutaka Kondo, Junya Shimazaki, Shin‐ichiro Shiraishi, Kei Hayashida, Shoji Yokobori, Shuhei Takauji, Masahiro Wakasugi, Shunsuke Nakamura, Jun Kanda, Masaharu Yagi, Takashi Moriya, Takashi Kawahara, Michihiko Tonouchi, Hiroyuki Yokota, Yasufumi Miyake, Keiki Shimizu, Ryosuke Tsuruta,
The Japanese Association for Acute Medicine Committee recently proposed a novel classification system for the severity of heat-related illnesses. The illnesses are simply classified into three stages based on symptoms and management or treatment. Stages I, II, and III broadly correspond to heat cramp and syncope, heat exhaustion, and heat stroke, respectively. Our objective was to examine whether this novel severity classification is useful in the diagnosis by healthcare professionals of patients ...
Tópico(s): Thermal Regulation in Medicine
2018 - Multidisciplinary Digital Publishing Institute | International Journal of Environmental Research and Public Health
Tatsuro Tamatsukuri, Masayuki Ohbayashi, Noriko Kohyama, Yasuna Kobayashi, Toshinori Yamamoto, Ken Fukuda, Shunsuke Nakamura, Yasufumi Miyake, Kenji Dohi, Mari Kogo,
In recent years, augmented renal clearance (ARC), in which renal function is excessively enhanced, has been reported, and its influence on β-lactam antibiotics has been investigated. In this study, we aimed to determine the optimum population pharmacokinetic model of meropenem in patients with sepsis with ARC, and evaluated dosing regimens based on renal function. Seventeen subjects (6 with ARC and 11 without) were enrolled in this study. Predicted meropenem concentrations were evaluated for bias ...
Tópico(s): Drug Transport and Resistance Mechanisms
2018 - Elsevier BV | Journal of Infection and Chemotherapy
Shaymaa Mohamed Mohamed Badawy, Taro Okada, Taketoshi Kajimoto, Mitsuhiro Hirase, Shubi Ambwene Matovelo, Shunsuke Nakamura, Daisuke Yoshida, Takeshi Ijuin, Shun‐ichi Nakamura,
α-Synuclein (α-Syn)-positive intracytoplasmic inclusions, known as Lewy bodies, are thought to be involved in the pathogenesis of Lewy body diseases, such as Parkinson's disease (PD). Although growing evidence suggests that cell-to-cell transmission of α-Syn is associated with the progression of PD and that extracellular α-Syn promotes formation of inclusion bodies, its precise mechanism of action in the extracellular space remains unclear. Here, as indicated by both conventional fractionation techniques ...
Tópico(s): Cellular transport and secretion
2018 - Elsevier BV | Journal of Biological Chemistry
Taketoshi Kajimoto, Nesma Nabil Ibrahim Mohamed, Shaymaa Mohamed Mohamed Badawy, Shubi Ambwene Matovelo, Mitsuhiro Hirase, Shunsuke Nakamura, Daisuke Yoshida, Taro Okada, Takeshi Ijuin, Shun‐ichi Nakamura,
Exosomes play a critical role in cell-to-cell communication by delivering cargo molecules to recipient cells. However, the mechanism underlying the generation of the exosomal multivesicular endosome (MVE) is one of the mysteries in the field of endosome research. Although sphingolipid metabolites such as ceramide and sphingosine 1-phosphate (S1P) are known to play important roles in MVE formation and maturation, the detailed molecular mechanisms are still unclear. Here, we show that Rho family GTPases, ...
Tópico(s): Cellular transport and secretion
2017 - Elsevier BV | Journal of Biological Chemistry
Shinichi Umeda, Mitsuro Kanda, Dai Shimizu, Shunsuke Nakamura, Koichi Sawaki, Yoshikuni Inokawa, Norifumi Hattori, Masamichi Hayashi, Chie Tanaka, Goro Nakayama, Yasuhiro Kodera,
Metastatic gastric cancer (GC) has a poor prognosis, and elucidating the molecular mechanisms involved in metastasis may lead to the development of novel therapeutic modalities. Transcriptome analysis of surgically resected metastatic tissue from GC patients and noncancerous tissue was performed to identify novel metastasis-related genes. Analyses of in vitro cell function, apoptosis, the cell cycle and cancer stemness were performed using GC cell lines with a stable knockout of a candidate gene. ...
Tópico(s): Signaling Pathways in Disease
2022 - Springer Science+Business Media | Gastric Cancer
J. Aalbers, Shehu AbdusSalam, K. Abe, Valentino Aerne, F. Agostini, S. Ahmed Maouloud, D. S. Akerib, D. Akimov, J Akshat, A. K. Al Musalhi, F. Alder, S. Alsum, L. Althueser, C. S. Amarasinghe, F. D. Amaro, A. Ames, Tyler Anderson, B. Andrieu, N. Angelides, E. Angelino, J. R. Angevaare, V. C. Antochi, D. Antón Martin, B. Antunović, E. Aprile, H. M. Araújo, J. E. Armstrong, F. Arneodo, M. Arthurs, Pouya Asadi, Seungwon Baek, X. Bai, D. Bajpai, Alexander A. Baker, J. Balajthy, S. Balashov, M. Balzer, A. Bandyopadhyay, J. Bang, E. L. Barberio, J. W. Bargemann, L. Baudis, D. Bauer, D. Baur, A. Baxter, A. Baxter, M Bazyk, K. Beattie, J. Behrens, Nicole F. Bell, L. Bellagamba, P. Beltrame, M. L. Benabderrahmane, E. P. Bernard, Gianfranco Bertone, Pijushpani Bhattacharjee, A. Bhatti, A. Biekert, T. P. Biesiadzinski, A R Binau, R. Biondi, Y. Biondi, H. J. Birch, Fady Bishara, A. Bismark, Carlos Blanco, G. M. Blockinger, E. Bodnia, Céline Bœhm, A. Bolozdynya, Patrick D. Bolton, Salvatore Bottaro, C. Bourgeois, B. Boxer, P. Brás, A. Breskin, P. A. Breur, C. Brew, Joachim Brod, E. J. Brookes, A. Brown, A. Brown, S. Bruenner, G. Bruno, R. Budnik, B. T. Khai, S. Burdin, S Buse, J.K. Busenitz, Dario Buttazzo, M. Buuck, A. Buzulutskov, R. Cabrita, Ce Cai, Dingbang Cai, C. Capelli, J. M. R. Cardoso, M. C. Carmona-Benitez, M. Cascella, Riccardo Catena, Sabyasachi Chakraborty, C. Chan, Spencer Chang, A. Chauvin, A. Chawla, H. Chen, V. Chepel, N. Chott, D. Cichon, A Cimental Chavez, B. Cimmino, M. Clark, Raymond T. Co, A. P. Colijn, Jan Conrad, M. V. Converse, Marco Costa, A. Cottle, G. A. Cox, Oisín Creaner, J J Cuenca Garcia, J. P. Cussonneau, J. E. Cutter, C. E. Dahl, V. D’Andrea, A. David, M. P. Decowski, James B. Dent, Frank F. Deppisch, L. de Viveiros, P. Di Gangi, A. Di Giovanni, S. Di Pede, J. Dierle, S. Diglio, J. E. Y. Dobson, M Doerenkamp, Delphine Douillet, G. Drexlin, E. Druszkiewicz, David I. Dunsky, K. Eitel, A. Elykov, Timón Emken, R. Engel, S. R. Eriksen, Malcolm Fairbairn, A. Fan, JiJi Fan, S. Farrell, Simon Fayer, N. M. Fearon, A. D. Ferella, C. Ferrari, A. Fieguth, A. Fieguth, S. Fiorucci, H. Fischer, H. Flaecher, M Flierman, Tess Florek, R. Foot, P. J. Fox, Roberto Franceschini, E. D. Fraser, Carlos S. Frenk, Steffen Fröhlich, T. Fruth, W. Fulgione, C Fuselli, P. Gaemers, R. Gaïor, R. J. Gaitskell, M. Galloway, F. Gao, Ignacio García‐Fernández, J. Genovesi, C. Ghag, Sayan Ghosh, E. F. Gibson, W Gil, D. Giovagnoli, F. Girard, R. Glade-Beucke, F. Glück, S. Gokhale, A. de Gouvêa, Lukas Graf, L. Grandi, J. Grigat, Benjaḿın Grinstein, M. G. D. van der Grinten, R. Grössle, H Guan, M. Guida, R Gumbsheimer, C. B. Gwilliam, C. Hall, L. J. Hall, R. Hammann, K. Han, V. Hannen, S. Hansmann-Menzemer, R Harata, S P Hardin, Edward Hardy, C.A. Hardy, Keisuke Harigaya, Roni Harnik, S. J. Haselschwardt, M.A. Hernández, S. A. Hertel, A. Higuera, C. Hils, S. Hochrein, L. Hoetzsch, Martin Hoferichter, Nicky Hood, D Hooper, M. Horn, J. Howlett, D. Q. Huang, Yuping Huang, Donald F. Hunt, M. Iacovacci, G. Iaquaniello, Ryushin Ide, C. M. Ignarra, G Iloglu, Y. Itow, E. Jacquet, O. Jahangir, J Jakob, R. S. James, A. Jansen, W. Ji, X Ji, F. Joerg, J. Johnson, A. Joy, A. C. Kaboth, Leila Kalhor, A. Kamaha, K Kanezaki, Kamales Kar, M. Kara, Natsuko Kato, P. Kavrigin, S. Kazama, A W Keaveney, J. Kellerer, D. Khaitan, A. Khazov, G. Khundzakishvili, I. Khurana, B. Kilminster, M. Kleifges, Pyungwon Ko, M. Kobayashi, D. Kodroff, G. Koltmann, A. Kopec, A. Kopmann, Joachim Kopp, L. Korley, В. Н. Корноухов, E. V. Korolkova, H. Kraus, Lawrence M. Krauss, S. Kravitz, L. Kreczko, V. A. Kudryavtsev, F. Kuger, Jason Kumar, B. López Paredes, L. LaCascio, R. Laha, Quentin Lainé, H. Landsman, R. F. Lang, E. Leason, J. Lee, D. S. Leonard, K. T. Lesko, L. J. Levinson, C. Levy, I. Li, S. Li, T. Li, S. Liang, C. S. Liebenthal, J. Lin, Q. Lin, S. Lindemann, M. Lindner, A. Lindote,
The nature of dark matter and properties of neutrinos are among the most pressing issues in contemporary particle physics. The dual-phase xenon time-projection chamber is the leading technology to cover the available parameter space for Weakly Interacting Massive Particles (WIMPs), while featuring extensive sensitivity to many alternative dark matter candidates. These detectors can also study neutrinos through neutrinoless double-beta decay and through a variety of astrophysical sources. A next-generation ...
IOP Publishing
Hiroyuki Watanabe, Toru Murata, Shunsuke Nakamura, Naoko Ikeo, Toshiji Mukai, Koichi Tsuchiya,
An equiatomic CrMnFeCoNi alloy is usually a single-phase solid-solution with a face-centered cubic (fcc) structure. However, a Cr-rich σ phase with a tetragonal structure is formed in coarse-grained alloys after extended heat treatment between 873 K and 1073 K, which is indicative of metastability of the CrMnFeCoNi alloy. In this study, it was demonstrated that cold-working facilitated σ-phase formation during heat treatment at 1073 K in (CrMnFeCoNi)100−xAlx (x = 8 and 9 at%). More specifically, the ...
Tópico(s): Additive Manufacturing Materials and Processes
2021 - Elsevier BV | Journal of Alloys and Compounds
Mitsuro Kanda, Dai Shimizu, Shunsuke Nakamura, Koichi Sawaki, Shinichi Umeda, Takashi Miwa, Haruyoshi Tanaka, Yoshikuni Inokawa, Norifumi Hattori, Masamichi Hayashi, Chie Tanaka, Goro Nakayama, Yohei Iguchi, Masahisa Katsuno, Yasuhiro Kodera,
Tópico(s): PI3K/AKT/mTOR signaling in cancer
2021 - Springer Nature | Oncogene
Tatsuo Nozaki, Toshiro Nagase, Yutaro Takaya, Toru Yamasaki, Tsubasa Otake, Kotaro Yonezu, Kei Ikehata, Shuhei Totsuka, Kazuya Kitada, Yoshinori Sanada, Yasuhiro Yamada, Jun‐ichiro Ishibashi, Hidenori Kumagai, Lena Maeda, Shigeshi Fuchida, Tatsuo Fukuhara, Kei Ikehata, Jun‐ichiro Ishibashi, Hirokazu Kato, Masanobu Kawachi, Shinji Kawaguchi, Ryuhei Kawakida, Kazuya Kitada, Shogo Komori, Hiroshi Koshikawa, Kakda Kret, Hidenori Kumagai, Lena Maeda, Yuka Masaki, Yohei Matsui, Iona M. McIntosh, Kana Minamide, Rena Miyahara, Nobuhiro Mukae, Toshiro Nagase, Shunsuke Nakamura, Tatsuo Nozaki, Masao Ohno, Tsubasa Otake, Masafumi Saitoh, Yoshinori Sanada, Yutaro Takaya, Tomohiro Toki, Junji Torimoto, Shuhei Totsuka, Akihi Tsutsumi, Riki Uehara, Hirotaka Uza, Masayuki Watanabe, Yasuhiro Yamada, Takahiro Yamagishi, Hirofumi Yamamoto, Toru Yamasaki, Kotaro Yonezu,
Abstract Seafloor massive sulphide (SMS) deposits, modern analogues of volcanogenic massive sulphide (VMS) deposits on land, represent future resources of base and precious metals. Studies of VMS deposits have proposed two emplacement mechanisms for SMS deposits: exhalative deposition on the seafloor and mineral and void space replacement beneath the seafloor. The details of the latter mechanism are poorly characterised in detail, despite its potentially significant role in global metal cycling throughout ...
Tópico(s): Geochemistry and Elemental Analysis
2021 - Nature Portfolio | Scientific Reports
Risa Araki, Kazunori Sasaki, Hiroyuki Onda, Shunsuke Nakamura, Masahiro Kassai, Toshiyuki Kaneko, Hiroko Isoda, Koichi Hashimoto,
We previously performed a 4 week interventional trial that suggested that continuous intake of rosemary extract improves the mood states, fatigue, and cognitive function of working generation healthy adult Japanese men. However, the severity of depression in participants in our previous study was relatively mild. Therefore, in the present study, a post-hoc analysis of our previous study was conducted, limited to participants whose total mood disturbance (TMD) scores, which indicate greater mood disturbance, ...
Tópico(s): Sleep and Wakefulness Research
2020 - Multidisciplinary Digital Publishing Institute | Nutrients
Nur Syahirah Kamal Baharin, Vidya Cundasari Koesoemadinata, Shunsuke Nakamura, Wira Jazair Yahya, Ali Yuzir, Fazrena Nadia Md Akhir, Koji Iwamoto, Nor’azizi Othman, Tamio IDA, Hirofumi Hara,
Depletion of fossil fuels and the adverse impacts burning these fuels has increased the attention towards utilizing biomass energy sources, thus increasing the focus on Bio-Coke technology, which can fully convert biomass waste into alternative fuels. This study analyzed the characteristics of Bio-Coke conversion from biomass abundantly found in Malaysia, which included rice husk, rubber wood sawdust, coconut husk, sugarcane bagasse, oil palm frond, oil palm trunk and empty fruit bunch (EFB). Results ...
Tópico(s): Forest Biomass Utilization and Management
2020 - Elsevier BV | Renewable Energy
Mitsuro Kanda, Dai Shimizu, Koichi Sawaki, Shunsuke Nakamura, Shinichi Umeda, Takashi Miwa, Haruyoshi Tanaka, Chie Tanaka, Masamichi Hayashi, Yohei Iguchi, Suguru Yamada, Masahisa Katsuno, Yasuhiro Kodera,
Abstract Background Controlling metastasis is essential for improving the prognosis of patients with gastric cancer (GC). Here, we aimed to identify a molecule required for GC metastasis and to investigate its potential utility as a target for the development of therapeutic antibodies (Abs). Methods Transcriptome and bioinformatics analyses of human GC cell lines identified the neuronal pentraxin receptor ( NPTXR ) as a candidate molecule. NPTXR function was probed by modulating its expression in GC cells ...
Tópico(s): Axon Guidance and Neuronal Signaling
2020 - BioMed Central | Molecular Cancer
Nur Syahirah Kamal Baharin, Vidya Cundasari Koesoemadinata, Shunsuke Nakamura, Nadia Farhana Azman, Ali Yuzir, Fazrena Nadia Md Akhir, Koji Iwamoto, Wira Jazair Yahya, Nor’azizi Othman, Tamio IDA, Hirofumi Hara,
Tópico(s): Lignin and Wood Chemistry
2020 - Springer Nature | Biomass Conversion and Biorefinery
Shunsuke Nakamura, Mitsuro Kanda, Masahiko Koike, Dai Shimizu, Shinichi Umeda, Norifumi Hattori, Masamichi Hayashi, Chie Tanaka, Daisuke Kobayashi, Suguru Yamada, Kenji Omae, Yasuhiro Kodera,
Tópico(s): Neuroendocrine Tumor Research Advances
2020 - Springer Science+Business Media | Annals of Surgical Oncology
Mitsuro Kanda, Yuuya Kasahara, Dai Shimizu, Takashi Miwa, Shinichi Umeda, Koichi Sawaki, Shunsuke Nakamura, Yasuhiro Kodera, Satoshi Obika,
Patients with peritoneal metastasis of gastric cancer have dismal prognosis, mainly because of inefficient systemic delivery of drugs to peritoneal tumors. We aimed to develop an intraperitoneal treatment strategy using amido-bridged nucleic acid (AmNA)-modified antisense oligonucleotides (ASOs) targeting synaptotagmin XIII (SYT13) and to identify the function of SYT13 in gastric cancer cells. We screened 71 candidate oligonucleotide sequences according to SYT13-knockdown efficacy, in vitro activity, ...
Tópico(s): PI3K/AKT/mTOR signaling in cancer
2020 - Cell Press | Molecular Therapy — Nucleic Acids
Shunsuke Nakamura, Eiki Iyoda, Tetsuo Deguchi, Takahiro Sagawa,
Information scrambling, characterized by the out-of-time-ordered correlator (OTOC), has attracted much attention, as it sheds new light on chaotic dynamics in quantum many-body systems. The scale invariance, which appears near the quantum critical region in condensed matter physics, is considered to be important for the fast decay of the OTOC. In this paper, we focus on the one-dimensional spin-1/2 XXZ model, which exhibits quantum criticality in a certain parameter region, and investigate the relationship ...
Tópico(s): Opinion Dynamics and Social Influence
2019 - American Physical Society | Physical review. B./Physical review. B
Kyoe Umeda, Shunsuke Nakamura, Lu Ding, Kunio Yoshikawa,
Low-temperature carbonization pretreatment for processing solid biomass provides an alternative to the standard use of raw biomass as a gasification feedstock. This low-temperature process is characterized by a comparable heating value, grindability, bulk density, and hydrophobicity to those of the standard. This study investigated the gasification characteristics of biomass carbonized at 300 °C, 350 °C, and 400 °C, and compared them to those of raw biomass from a lab-scale gasification facility with ...
Tópico(s): activated carbon and charcoal
2019 - Elsevier BV | Biomass and Bioenergy
Nami Yamaguchi, Etsuo Chosa, Kara Yamamoto, Kunimitsu Kawahara, Hirotaka Hamada, Naoyuki Taniguchi, Takuya Tajima, Taro Funamoto, Syuji Kurogi, Tomomi Ota, Shunsuke Nakamura,
To clarify the frequency of musculoskeletal problems in public elementary and junior high school children and to determine the advantages and problems of musculoskeletal examinations. School-based cross-sectional study nested in a cohort. We examined 41,376 public elementary and junior high school children (aged 6–15 years) in Miyazaki, Japan, from 2008 to 2014. Participation was voluntary. Participants received an in-school primary musculoskeletal examination (clinical examination with check items ...
Tópico(s): Sports injuries and prevention
2016 - Elsevier BV | Public Health
Shunsuke Nakamura, Shigeru Kitano, Kunio Yoshikawa,
We develop tar removal technologies by using byproducts (bio-oil and char) in order to achieve low-cost and highly effective tar removal using only secondary removal methods in a pilot-scale gasification facility. The tar removal performance of a 100-L bio-oil scrubber and a 13-kg char filter is investigated with an up-draft gasifier. The tar removal rate of the bio-oil scrubber at 40, 50, and 60 °C is measured; the highest removal rate is 64.5% at 50 °C. Furthermore, even though the tar removal performance ...
Tópico(s): Recycling and Waste Management Techniques
2016 - Elsevier BV | Applied Energy
Takenori Akiyama, Ken Okazaki, Taro Mawatari, Satoshi Ikemura, Shunsuke Nakamura,
Osteophytes are physiological bony outgrowths that develop at the margins of the articular surfaces during the progression of osteoarthritis; they are associated with active endochondral bone formation processes and expressions of various growth factors. We believe they could be a source of bone grafts as a result of a potentially strong osteoinductive effect. Moreover, osteophytes can be easily harvested by arthroscopy in patients undergoing open-wedge high tibial osteotomy (OW-HTO) for medial unicompartmental ...
Tópico(s): Bone fractures and treatments
2016 - Elsevier BV | Arthroscopy Techniques
Shunsuke Nakamura, Siriwat Unyaphan, Kunio Yoshikawa, Shigeru Kitano,
The technical obstacle of biomass gasification technology is the effective removal of tar, which will cause the clogging of pipes and engines. In this research, in order to develop the low-cost and high-efficiency tar removal technologies, the tar removal performances of bio-oil and char, which are the by-products of biomass gasification processes, were investigated. For this research, the scrubber with 100L of bio-oil and the char bed with 10 kg of char and 3 kg of activated carbon were prepared ...
Tópico(s): activated carbon and charcoal
2015 - Elsevier BV | Energy Procedia
Yoshinobu Saitoh, Takao Setoguchi, Masahito Nagata, Arisa Tsuru, Shunsuke Nakamura, Satoshi Nagano, Yasuhiro Ishidou, Hiroko Nagao‐Kitamoto, Masahiro Yokouchi, Shingo Maeda, Akihide Tanimoto, Tatsuhiko Furukawa, Setsuro Komiya,
High-dose chemotherapy and surgical intervention have improved long-term prognosis for non-metastatic osteosarcoma to 50-80%. However, metastatic osteosarcoma exhibits resistance to standard chemotherapy. We and others have investigated the function of Hedgehog pathway in osteosarcoma. To apply our previous findings in clinical settings, we examined the effects of Hedgehog inhibitors including arsenic trioxide (ATO) and vismodegib combined with standard anticancer agents. We performed WST-1 assays ...
Tópico(s): Cancer-related Molecular Pathways
2015 - Spandidos Publishing | International Journal of Oncology
Shunsuke Nakamura, Siriwat Unyaphan, Kunio Yoshikawa, Shigeru Kitano, Shuji Kimura, Hiroyuki Shimizu, Kazuya Taira,
Biomass gasification is an attractive power generation technology that can generate electricity without any increase of CO2 concentration in the atmosphere. However, many technical problems have still to be overcome. The biggest technical obstacle for the operation of a commercial gasification plant is the elimination of tar in the producer gas. Tar will condense at the ambient temperature and will cause clogging of pipes and engines. Therefore, effective and economical tar removal methods are required. ...
Tópico(s): Combustion and flame dynamics
2014 - Taylor & Francis | Biofuels
K. Abe, Kotaro Hieda, K. Hiraide, Shingo Hirano, Y. Kishimoto, K. Ichimura, K. Kobayashi, S. Moriyama, Keizo Nakagawa, M. Nakahata, H. Ogawa, Natsuhisa Oka, H. Sekiya, A. Shinozaki, Y. Suzuki, A. Takeda, O. Takachio, D. Umemoto, M. Yamashita, B. S. Yang, S. Tasaka, J. Liu, K. Martens, K. Hosokawa, K. Miuchi, Akiko Murata, Y. Onishi, Y. Otsuka, Y. Takeuchi, Y. H. Kim, K. B. Lee, M. K. Lee, J. S. Lee, Y. Fukuda, Y. Itow, K. Masuda, H. Takiya, Hirohisa Uchida, N. Y. Kim, Y. D. Kim, F. Kusaba, K. Nishijima, Kotaro Fujii, I. Murayama, Shunsuke Nakamura,
Bosonic superweakly interacting massive particles (super-WIMPs) are a candidate for warm dark matter. With the absorption of such a boson by a xenon atom these dark matter candidates would deposit an energy equivalent to their rest mass in the detector. This is the first direct detection experiment exploring the vector super-WIMPs in the mass range between 40 and 120 keV. Using 165.9 days of data no significant excess above background was observed in the fiducial mass of 41 kg. The present limit ...
Tópico(s): Cosmology and Gravitation Theories
2014 - American Physical Society | Physical Review Letters
Hiroko Nagao‐Kitamoto, Takao Setoguchi, Sho Kitamoto, Shunsuke Nakamura, Arisa Tsuru, Masahito Nagata, Satoshi Nagano, Yasuhiro Ishidou, Masahiro Yokouchi, Shinichi Kitajima, Takako Yoshioka, Shingo Maeda, Suguru Yonezawa, Setsuro Komiya,
It has been reported that GLI2 promotes proliferation, migration, and invasion of mesenchymal stem cell and osteosarcoma cells. To examine the molecular mechanisms of GLI2-mediated osteosarcoma metastasis, we performed a microarray analysis. The gene encoding ribosomal protein S3 (RPS3) was identified as a target of GLI2. Real-time PCR revealed that RPS3 was upregulated in osteosarcoma cell lines compared with normal osteoblast cells. Knockdown of GLI2 decreased RPS3 expression, whereas forced expression ...
Tópico(s): Cholangiocarcinoma and Gallbladder Cancer Studies
2014 - Elsevier BV | Cancer Letters