Produção Nacional
Revisado por pares
Andréa Silvestre de Sousa, Debbie Vermeij, Alberto Novaes Ramos, Alejandro O. Luquetti,
Chagas disease persists as a global public health problem due to the high morbidity and mortality burden. Despite the possibility of a cure and advances in transmission control, epidemiological transformations, such as urbanisation and globalisation, and the emerging importance of oral and vertical transmission mean that Chagas disease should be considered an emerging disease, with new cases occurring worldwide. Important barriers to diagnosis, treatment, and care remain, resulting in repressed ...
Tópico(s): Parasites and Host Interactions
2023 - Elsevier BV | The Lancet
José Antônio Marin‐Neto, Anis Rassi, Gláucia Maria Moraes de Oliveira, Luís Cláudio Lemos Correia, Alberto Novaes Ramos, Alejandro O. Luquetti, Alejandro Marcel Hasslocher‐Moreno, Andréa Silvestre de Sousa, Angêlo Amato Vincenzo de Paola, Antônio Carlos Sobral Sousa, Antônio Luiz Pinho Ribeiro, Dalmo Correia, Dilma do Socorro Moraes de Souza, Edécio Cunha‐Neto, Félix José Alvarez Ramires, Fernando Bacal, Maria do Carmo Pereira Nunes, Martino Martinelli Filho, Maurício Scanavacca, Roberto Magalhães Saraiva, Wilson Alves de Oliveira, Adalberto M. Lorga-Filho, Adriana de Jesus Benevides de Almeida Guimarães, Adriana Lopes Latado, Adriana Sarmento de Oliveira, Álvaro Valentim Lima Sarabanda, Ana Yecê das Neves Pinto, André Assis Lopes do Carmo, André Schmidt, A. Costa, Bárbara Maria Ianni, Brivaldo Markman, Carlos Eduardo Rochitte, Carolina Thé Macêdo, Charles Mady, Christophe Chevillard, Cláudio Marcelo Bittencourt das Virgens, Cleudson Castro, Constança Britto, Cristiano Pisani, Daniela do Carmo Rassi, Dário Celestino Sobral Filho, Dirceu Rodrigues Almeida, Edimar Alcides Bocchi, Evandro Tinoco Mesquita, Fernanda de Souza Nogueira Sardinha Mendes, Francisca Tatiana Moreira Pereira, Gilberto Marcelo Sperandio da Silva, Giselle de Lima Peixoto, Gustavo Glotz de Lima, Henrique Horta Veloso, Henrique Turin Moreira, Hugo Bellotti Lopes, Ibraim Pinto, João Marcos Bemfica Barbosa Ferreira, João Paulo Silva Nunes, José Augusto Soares Barreto-Filho, José Francisco Kerr Saraiva, Joseli Lannes-Vieira, Joselina Luzia Menezes Oliveira, Luciana Armaganijan, Luíz Cláudio Martins, Luiz Henrique Conde Sangenis, Marco Paulo Tomaz Barbosa, Marcos Antônio Almeida-Santos, Marcos Vinicius Simões, Maria Aparecida Shikanai‐Yasuda, Maria da Consolação Vieira Moreira, Maria de Lourdes Higuchi, M. Monteiro, Mauro Felippe Felix Mediano, Mayara Maia Lima, Maykon Tavares de Oliveira, Minna Moreira Dias Romano, Nadjar Nitz, Paulo de Tarso Jorge Medeiros, Renato Vieira Alves, Ricardo Alkmim Teixeira, Roberto Coury Pedrosa, Roque Aras, Rosália Morais Tôrres, Rui Póvoa, Sérgio Gabriel Rassi, Sílvia Marinho Martins Alves, Suelene Brito do Nascimento Tavares, Swamy Lima Palmeira, Telêmaco Luiz da Silva, Thiago da Rocha Rodrigues, Vagner Madrini, Veruska Maia da Costa, Walderez O. Dutra, João Carlos Pinto Dias,
Lista de Siglas/Abreviaturas 18 F-FDG – fluordesoxiglicose marcado com flúor-18 123 I-MIBG – meta-iodo-benzil-guanidina marcado com iodo-123 […] Diretriz da SBC sobre Diagnóstico e Tratamento de Pacientes com Cardiomiopatia da Doença de Chagas – 2023
Tópico(s): Trypanosoma species research and implications
2023 - Sociedade Brasileira de Cardiologia (SBC) | Arquivos Brasileiros de Cardiologia
Produção Nacional
Revisado por pares
Rosália Morais Tôrres, Dalmo Correia, Maria do Carmo Pereira Nunes, Walderez O. Dutra, André Talvani, Andréa Silvestre de Sousa, Fernanda de Souza Nogueira Sardinha Mendes, Maurício Scanavacca, Cristiano Pisani, Maria da Consolação Vieira Moreira, Dilma do Socorro Moraes de Souza, Wilson de Oliveira, Sílvia Marinho Martins Alves, João Carlos Pinto Dias,
In this chapter, the main prognostic markers of Chagas heart disease are addressed, with an emphasis on the most recent findings and questions, establishing the basis for a broad discussion of recommendations and new approaches to managing Chagas cardiopathy. The main biological and genetic markers and the contribution of the electrocardiogram, echocardiogram and cardiac magnetic resonance are presented. We also discuss the most recent therapeutic proposals for heart failure, thromboembolism and ...
Tópico(s): Viral Infections and Immunology Research
2022 - Instituto Oswaldo Cruz, Ministério da Saúde | Memórias do Instituto Oswaldo Cruz
Produção Nacional
Revisado por pares
Marcelo Teixeira de Holanda, Mauro Felippe Felix Mediano, Alejandro Marcel Hasslocher‐Moreno, Beatriz Matheus de Souza Gonzaga, Anna Cristina Calçada Carvalho, Roberto Rodrigues Ferreira, Luciana Ribeiro Garzoni, Fernanda Sant’Ana Pereira-Silva, Luis O. Pimentel, Marcelo Oliveira Mendes, Marcos José de Azevedo, Constança Britto, Otacílio C. Moreira, Alice Gomes Fernandes, Carolina Santos, Jéssica Constermani, Vitor Barreto Paravidino, Erica Rodrigues Maciel, Fernanda Martins Carneiro, Sérgio Salles Xavier, Gilberto M. Sperandio da Silva, Priscila F. Santos, Henrique Horta Veloso, Pedro Emmanuel Alvarenga Americano do Brasil, Andréa Silvestre de Sousa, Maria G. Bonecini-de-Almeida, Paula Simplício da Silva, Luiz Henrique Conde Sangenis, Roberto Magalhães Saraiva, Tânia Cremonini de Araújo-Jorge,
Chagas disease (caused by Trypanosoma cruzi infection) evolves to chronic chagasic cardiomyopathy (CCC) affecting 1.8 million people worldwide. This is the first randomized, placebo-controlled, double-blinded, clinical trial designed to estimate efficacy and safety of selenium (Se) treatment in CCC.66 patients with CCC stages B1 (left ventricular ejection fraction [LVEF] > 45% and no heart failure; n = 54) or B2 (LVEF < 45% and no heart failure; n = 12) were randomly assigned to receive 100 mcg/day sodium selenite ( ...
Tópico(s): Cardiovascular Issues in Pregnancy
2021 - Elsevier BV | EClinicalMedicine
Produção Nacional
Revisado por pares
Maria Aparecida Shikanai‐Yasuda, Mauro Felippe Felix Mediano, Christina Terra Gallafrio Novaes, Andréa Silvestre de Sousa, Ana Marli Christovam Sartori, Rodrigo de Carvalho Santana, Dalmo Correia, Cleudson Castro, Marilia Maria dos Santos Severo, Alejandro Marcel Hasslocher‐Moreno, Marisa Fernández, Fernando Salvador, María‐Jesús Pinazo, Valdes Roberto Bolella, Pedro Carvalho Furtado, Marcelo Corti, Ana Yecê Neves Pinto, Alberto Fíca, Israel Molina, Joaquím Gascón, Pedro Albajar-Viñas, Juan José Cortez-Escalante, Alberto Novaes Ramos, Eros Antônio de Almeida,
Objective Chagas disease (CD) globalization facilitated the co-infection with Human Immunodeficiency Virus (HIV) in endemic and non-endemic areas. Considering the underestimation of Trypanosoma cruzi (T . cruzi) -HIV co-infection and the risk of life-threatening Chagas Disease Reactivation (CDR), this study aimed to analyze the major co-infection clinical characteristics and its mortality rates. Methods This is a cross-sectional retrospective multicenter study of patients with CD confirmed by two serological ...
Tópico(s): Parasites and Host Interactions
2021 - Public Library of Science | PLoS neglected tropical diseases
Produção Nacional
Revisado por pares
Renato D. Lópes, Ariane Vieira Scarlatelli Macedo, Pedro Gabriel Melo de Barros e Silva, Renata Moll-Bernardes, T Mendonca, Lilian Mazza, André Feldman, Guilherme Arruda, Denílson Campos de Albuquerque, Angelina Camiletti, Andréa Silvestre de Sousa, Thiago Ceccatto de Paula, Karla G. D. Giusti, Rafael Domiciano, Márcia Noya-Rabelo, Alan M. Hamilton, Vitor Alves Loures, Rodrigo M. Dionísio, Thyago Antônio Biagioni Furquim, Fábio Augusto de Luca, Ítalo Bruno dos Santos Sousa, Bruno Santana Bandeira, Cleverson Zukowski, Ricardo Oliveira, Noara Barros Ribeiro, Jeffer L. de Moraes, João Luiz Fernandes Petriz, Adriana M. Pimentel, Jacqueline S. Miranda, Barbara Abufaiad, C. Michael Gibson, Christopher B. Granger, John H. Alexander, Olga Ferreira de Souza,
Importance It is unknown whether angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin II receptor blockers (ARBs) have a positive, neutral, or negative effect on clinical outcomes in patients with coronavirus disease 2019 (COVID-19). Objective To determine whether discontinuation compared with continuation of ACEIs or ARBs changed the number of days alive and out of the hospital through 30 days. Design, Setting, and Participants A randomized clinical trial of 659 patients hospitalized in Brazil with ...
Tópico(s): COVID-19 and Mental Health
2021 - American Medical Association | JAMA
Produção Nacional
Revisado por pares
Renata Moll-Bernardes, Andréa Silvestre de Sousa, Ariane Vieira Scarlatelli Macedo, Renato D. Lópes, Narendra Vera, Luciana C. R. Maia, André Feldman, Guilherme D. A. S. Arruda, Mauro Jorge Cabral‐Castro, Pedro M. Pimentel‐Coelho, Denílson Campos de Albuquerque, Thiago Ceccatto de Paula, Thyago Antônio Biagioni Furquim, Vitor Alves Loures, Karla G. D. Giusti, Nathália M. de Oliveira, Fábio Augusto de Luca, Marisol D. M. Kotsugai, Rafael Domiciano, Mayara Fraga Santos, Olga Ferreira de Souza, Fernando A. Bozza, Ronir Raggio Luiz, Emiliano Medei,
Background: Cardiovascular comorbidities such as hypertension and inflammatory response dysregulation are associated with worse COVID-19 prognoses. Different cytokines have been proposed to play vital pathophysiological roles in COVID-19 progression, but appropriate prognostic biomarkers remain lacking. We hypothesized that the combination of immunological and clinical variables at admission could predict the clinical progression of COVID-19 in hypertensive patients. Methods: The levels of biomarkers, ...
Tópico(s): Adipokines, Inflammation, and Metabolic Diseases
2021 - Frontiers Media | Frontiers in Cardiovascular Medicine
Produção Nacional
Roberto Magalhães Saraiva, Mauro Felippe Felix Mediano, Fernanda Sns Mendes, Gilberto Marcelo Sperandio da Silva, Henrique Horta Veloso, Luiz Henrique Conde Sangenis, Paula Simplício da Silva, Flavia Mazzoli‐Rocha, Andréa Silvestre de Sousa, Marcelo Teixeira de Holanda, Alejandro Marcel Hasslocher‐Moreno,
Chagas heart disease (CHD) affects approximately 30% of patients chronically infected with the protozoa Trypanosoma cruzi. CHD is classified into four stages of increasing severity according to electrocardiographic, echocardiographic, and clinical criteria. CHD presents with a myriad of clinical manifestations, but its main complications are sudden cardiac death, heart failure, and stroke. Importantly, CHD has a higher incidence of sudden cardiac death and stroke than most other cardiopathies, and ...
Tópico(s): Cardiac Arrhythmias and Treatments
2021 - | World Journal of Cardiology
Produção Nacional
Revisado por pares
Alejandro Marcel Hasslocher‐Moreno, Sérgio Salles Xavier, Roberto Magalhães Saraiva, Luiz Henrique Conde Sangenis, Marcelo Teixeira de Holanda, Henrique Horta Veloso, Andréa Rodrigues da Costa, Fernanda de Souza Nogueira Sardinha Mendes, Pedro Emmanuel Alvarenga Americano do Brasil, Gilberto Marcelo Sperandio da Silva, Mauro Felippe Felix Mediano, Andréa Silvestre de Sousa,
Most patients with chronic Chagas disease (CD) present the indeterminate form and are at risk to develop the cardiac form. However, the actual rate of progression to the cardiac form is still unknown.In total, 550 patients with the indeterminate CD form were followed by means of annual electrocardiogram at our outpatient clinic. The studied endpoint was progression to cardiac form defined by the appearance of electrocardiographic changes typical of CD. The progression rate was calculated as the cumulative ...
Tópico(s): Cardiomyopathy and Myosin Studies
2020 - Multidisciplinary Digital Publishing Institute | Tropical Medicine and Infectious Disease
Produção Nacional
Revisado por pares
Fernanda de Souza Nogueira Sardinha Mendes, Mauro Felippe Felix Mediano, Fernando César de Castro e Souza, Paula Simplício da Silva, Fernanda Martins Carneiro, Marcelo Teixeira de Holanda, Roberto Magalhães Saraiva, Sérgio Salles Xavier, Pedro Emmanuel Alvarenga Americano do Brasil, Andréa Silvestre de Sousa,
•Exercise training improved functional capacity in Chagas heart disease. •Exercisers tolerate higher loads of exercise after 3- and 6 months of follow-up. •Exercise may constitute a coadjuvant strategy for patients with Chagas heart disease. Chagas heart disease (HD) is a chronic fibrosing myocarditis with high mortality. The PEACH study aimed to evaluate if exercise training can improve the functional capacity of Chagas HD patients with left ventricular dysfunction and/or heart failure. The PEACH ...
Tópico(s): Cardiomyopathy and Myosin Studies
2020 - Elsevier BV | The American Journal of Cardiology
Produção Nacional
Revisado por pares
Martha Valéria Tavares Pinheiro, Renata Moll-Bernardes, Gabriel Camargo, Fabio Paiva Rossini Siqueira, Clerio F. Azevedo, Marcelo Teixeira de Holanda, Fernanda de Souza Nogueira Sardinha Mendes, Luiz Henrique Conde Sangenis, Mauro Felippe Felix Mediano, Andréa Silvestre de Sousa,
Chronic Chagas disease can progress to myocardial involvement with intense fibrosis, which may predispose patients to sudden cardiac death through ventricular arrhythmia. The associations of myocardial fibrosis detected by cardiac magnetic resonance (CMR) parameters with non-sustained ventricular tachycardia (NSVT) were evaluated. This cross-sectional study included patients in early stages of Chagas disease (n = 47) and a control group (n = 15). Patients underwent cardiac evaluation, including CMR examination. ...
Tópico(s): Viral Infections and Immunology Research
2020 - American Society of Tropical Medicine and Hygiene | American Journal of Tropical Medicine and Hygiene
Produção Nacional
Revisado por pares
Emily Ferreira dos Santos, Ângelo Antônio Oliveira Silva, Leonardo Maia Leony, Natália Erdens Maron Freitas, Ramona Tavares Daltro, Carlos Gustavo Régis-Silva, Rodrigo P. Del-Rei, Wayner Vieira de Souza, Alejandro Luquetti Ostermayer, Veruska Maia da Costa, Rafaella A. Silva, Alberto Novaes Ramos, Andréa Silvestre de Sousa, Yara M. Gomes, Fred Luciano Neves Santos,
Background In Brazil, acute Chagas disease (ACD) surveillance involves mandatory notification, which allows for population-based epidemiological studies. We conducted a nationwide population-based ecological analysis of the spatiotemporal patterns of ACD notifications in Brazil using secondary surveillance data obtained from the Notifiable Diseases Information System (SINAN) maintained by Brazilian Ministry of Health. Methodology/Principal findings In this nationwide population-based ecological all ...
Tópico(s): Insect symbiosis and bacterial influences
2020 - Public Library of Science | PLoS neglected tropical diseases
Produção Nacional
Revisado por pares
Alejandro Marcel Hasslocher‐Moreno, Roberto Magalhães Saraiva, Luiz Henrique Conde Sangenis, Sérgio Salles Xavier, Andréa Silvestre de Sousa, Andréa Rodrigues da Costa, Marcelo Teixeira de Holanda, Henrique Horta Veloso, Fernanda S. N. S. Mendes, Filipe Aníbal Carvalho‐Costa, Márcio Neves Bóia, Pedro Emmanuel Alvarenga Americano do Brasil, Fernanda Martins Carneiro, Gilberto M. Sperandio da Silva, Mauro Felippe Felix Mediano,
Chagas disease (CD) remains an important endemic disease in Latin America. However, CD became globalized in recent decades. The majority of the chronically infected individuals did not receive etiologic treatment for several reasons, among them the most conspicuous is the lack of access to diagnosis. The impact of trypanocidal treatment on CD chronic phase, without cardiac involvement (indeterminate form ICF), is yet to be determined. We aimed to evaluate the effect of trypanocidal treatment with ...
Tópico(s): Research on Leishmaniasis Studies
2020 - Elsevier BV | EClinicalMedicine
Produção Nacional
Revisado por pares
Roberto Magalhães Saraiva, Nicole P. Pacheco, Thayanne O.J.S. Pereira, Andréa Rodrigues da Costa, Marcelo Teixeira de Holanda, Luiz Henrique Conde Sangenis, Fernanda S. N. S. Mendes, Andréa Silvestre de Sousa, Alejandro Marcel Hasslocher‐Moreno, Sérgio Salles Xavier, Mauro Felippe Felix Mediano, Henrique Horta Veloso,
Highlights•The authors evaluated predictors of new-onset AF in Chagas disease.•AF occurred in 11% of patients during a mean follow-up period of 5.6 years.•Almost half of patients were asymptomatic at the time of diagnosis.•LA function was an independent predictor of new-onset AF.•Total LA emptying fraction was the best predictor of AF among LA function parameters.AbstractBackgroundAtrial fibrillation (AF) carries ominous consequences in patients with Chagas disease. The aim of this study was to determine ...
Tópico(s): Trypanosoma species research and implications
2020 - Elsevier BV | Journal of the American Society of Echocardiography
Produção Nacional
Revisado por pares
Mayara da Costa Chambela, Mauro Felippe Felix Mediano, Fernanda Martins Carneiro, Roberto Rodrigues Ferreira, Mariana Caldas Waghabi, Verônica Gonçalves Mendes, Luciano de Souza Oliveira, Marcelo Teixeira de Holanda, Andréa Silvestre de Sousa, Andréa Rodrigues da Costa, Sérgio Salles Xavier, Gilberto Marcelo Sperandio da Silva, Roberto Magalhães Saraiva,
Aims Chronic Chagas disease (ChD) has high morbimortality and loss in quality of life due to heart failure (HF). Pharmaceutical care (PC) optimizes clinical treatment and can improve quality of life in HF. We evaluated if PC improves quality of life of patients with ChD and HF. Methods Single‐blinded, randomized, controlled trial that assigned adult patients with ChD and HF (81 patients; 61 ± 11 years; 48% male) to PC ( n = 40) or standard care ( n = 41). Quality of life according to SF‐36 and Minnesota living ...
Tópico(s): Synthesis and Biological Evaluation
2019 - Wiley | British Journal of Clinical Pharmacology
Produção Nacional
Revisado por pares
Eliza de Almeida Gripp, Gabriela Escudini de Oliveira, Luiz Augusto Feijó, Marcelo Iório Garcia, Sérgio Salles Xavier, Andréa Silvestre de Sousa,
Background: The high cardiotoxicity morbidity and mortality rates associated with the antineoplastic therapy for breast cancer could be reduced with the early use of cardioprotective drugs. However, the low sensitivity of left ventricular ejection fraction limits its use in that preventive strategy. New parameters, such as global longitudinal strain, are being used in the early detection of contractile function changes. Objectives: To assess the incidence of cardiotoxicity in patients treated for ...
Tópico(s): Cardiac Imaging and Diagnostics
2018 - Sociedade Brasileira de Cardiologia (SBC) | Arquivos Brasileiros de Cardiologia
Produção Nacional
Revisado por pares
João C. L. Santos‐Filho, Marcelo Carvalho Vieira, Isis Gabrielli Gomes Xavier, Erica Rodrigues Maciel, Luiz Fernando Rodrigues, Eduardo OV Curvo, Iane M. Pereira, Marcel de Souza Borges Quintana, Gilberto M. Sperandio da Silva, Henrique Horta Veloso, Fernanda S. N. S. Mendes, Alejandro Marcel Hasslocher‐Moreno, Andréa Silvestre de Sousa, Pedro Emmanuel Alvarenga Americano do Brasil, Roberto Magalhães Saraiva, Mauro Felippe Felix Mediano,
To evaluate the quality of life (QoL) of patients with Chagas disease (CD) and the association between QoL domains and several clinical, socioeconomic and lifestyle characteristics of this population.Cross-sectional observational study conducted from March 2014 to March 2017 including a total of 361 outpatients followed at Evandro Chagas National Institute of Infectious Disease, Brazil. QoL was assessed using the Portuguese shorter version of the original WHO Quality of Life questionnaire (WHOQOL-BREF). ...
Tópico(s): Trypanosoma species research and implications
2018 - Wiley | Tropical Medicine & International Health
Produção Nacional
Revisado por pares
Ícaro Rodrigues-dos-Santos, Myllena F. A. D. Melo, Liane de Castro, Alejandro Marcel Hasslocher‐Moreno, Pedro Emmanuel Alvarenga Americano do Brasil, Andréa Silvestre de Sousa, Constança Britto, Otacílio C. Moreira,
Chagas disease is still a major public health issue in many Latin American countries. One of the current major challenges is to find an association between Trypanosoma cruzi discrete typing units (DTUs) and clinical manifestations of the disease. In this study, we used a multilocus conventional PCR and quantitative real time PCR (qPCR) approaches to perform the molecular typing and parasite load quantification directly from blood specimens of 65 chronic Chagas disease patients. All patients were recruited ...
Tópico(s): Research on Leishmaniasis Studies
2018 - Public Library of Science | PLoS neglected tropical diseases
Produção Nacional
Revisado por pares
Mauro Felippe Felix Mediano, Fernanda de Souza Nogueira Sardinha Mendes, Vivian Liane Mattos Pinto, Paula Simplício da Silva, Alejandro Marcel Hasslocher‐Moreno, Andréa Silvestre de Sousa,
We evaluated the effects of a cardiac rehabilitation program on quality of life.This secondary analysis of a single-arm study included 12 patients with Chagas heart failure. The cardiac rehabilitation program comprised exercise training and nutritional and pharmaceutical counseling. Quality of life was assessed using the SF-36 questionnaire.The program promoted improved physical functioning (β= +5.7; p=0.003), role-physical (β= +1.9; p=0.03), and bodily pain (β= +3.5; p=0.02) scores. Moreover, the summary ...
Tópico(s): Cardiovascular Function and Risk Factors
2017 - Brazilian Society of Tropical Medicine | Revista da Sociedade Brasileira de Medicina Tropical
Produção Nacional
Revisado por pares
Gilberto Marcelo Sperandio da Silva, Mauro Felippe Felix Mediano, Alejandro Marcel Hasslocher‐Moreno, Marcelo Teixeira de Holanda, Andréa Silvestre de Sousa, Luiz Henrique Conde Sangenis, Pedro Emmanuel Alvarenga Americano do Brasil, Roger Arteaga Mejía, Carina Perotti Fux, Juan-Carlos Cubides, Roberto Magalhães Saraiva, Lucia Maria Brum-Soares,
Up to half of patients with Chagas' disease under benznidazole treatment present adverse drug reactions (ADRs) and up to one-third do not complete standard treatment. To verify the incidence and possible factors associated with the suspension of benznidazole treatment in a large cohort of patients. We included 2075 patients treated with benznidazole during the projects managed by the medical humanitarian organization Doctors Without Borders (Médecins Sans Frontières) in Bolivia from 2009 to 2013. ...
Tópico(s): Insect symbiosis and bacterial influences
2017 - Oxford University Press | Journal of Antimicrobial Chemotherapy
Produção Nacional
Revisado por pares
Alberto Novaes Ramos, Andréa Silvestre de Sousa,
Tópico(s): Research on Leishmaniasis Studies
2017 - Brazilian Society of Tropical Medicine | Revista da Sociedade Brasileira de Medicina Tropical
Produção Nacional
Revisado por pares
Paula Simplício da Silva, Mauro Felippe Felix Mediano, Gilberto Marcelo Sperandio da Silva, Patrícia Dias de Brito, Cláudia Santos de Aguiar Cardoso, Cristiane Fonseca de Almeida, Luiz Henrique Conde Sangenis, Roberta Olmo Pinheiro, Alejandro Marcel Hasslocher‐Moreno, Pedro Emmanuel Alvarenga Americano do Brasil, Andréa Silvestre de Sousa,
Several studies have been focusing on the effect of omega-3 polyunsaturated fatty acids on modulation of inflammatory markers in several cardiopathies. Although immunoregulatory dysfunction has been associated to the chronic cardiac involvement in Chagas disease, there is no study examining the effects of omega-3 supplementation in these patients. We investigated the effects of omega-3 PUFAs on markers of inflammation and lipid profile in chronic Chagas cardiomyopathy patients.The present study ...
Tópico(s): Coenzyme Q10 studies and effects
2017 - BioMed Central | Nutrition Journal
Produção Nacional
João Carlos Pinto Dias, Alberto Novaes Ramos, Eliane Dias Gontijo, Alejandro O. Luquetti, Maria Aparecida Shikanai‐Yasuda, José Rodrigues Coura, Rosália Morais Tôrres, José Renan da Cunha Melo, Eros Antônio de Almeida, Wilson de Oliveira, Antônio Carlos Silveira, Joffre Marcondes de Rezende, Fabiane Scalabrini Pinto, Antônio Walter Ferreira, Anis Rassi, Abílio Augusto Fragata Filho, Andréa Silvestre de Sousa, Dalmo Correia, Ana María Jansen, Gláucia Manzan Queiroz de Andrade, Constança Britto, Ana Yecê das Neves Pinto, Anis Rassi, Dayse Elisabeth Campos, Fernando Abad‐Franch, Silvana Eloi Santos, Égler Chiari, Alejandro Marcel Hasslocher‐Moreno, Eliane Furtado Moreira, Divina Seila de Oliveira Marques, Divina Seila de Oliveira Marques, Eliane Lages Silva, José Antonio Marin-Neto, Lúcia Maria da Cunha Galvão, Sérgio Salles Xavier, Sebastião Aldo da Silva Valente, Noêmia Barbosa Carvalho, Alessandra Viana Cardoso, Rafaella Albuquerque e Silva, Veruska Maia da Costa, Simone Monzani Vivaldini, Suelene Mamede Oliveira, Vera da Costa Valente, Mayara Maia Lima, Renato Vieira Alves,
Chagas disease is a neglected chronic condition that presents high morbidity and mortality burden, with considerable psychological, social, and economic impact.The disease represents a significant public health issue in Brazil, with different regional patterns.This document presents the evidence that resulted in the Brazilian Consensus on Chagas Disease.The objective was to review and standardize strategies for diagnosis, treatment, prevention, and control of Chagas disease in the country, based ...
Tópico(s): Trypanosoma species research and implications
2016 - MINISTÉRIO DA SAÚDE | Epidemiologia e Serviços de Saúde
Produção Nacional
Revisado por pares
Mauro Felippe Felix Mediano, Fernanda de Souza Nogueira Sardinha Mendes, Vivian Liane Mattos Pinto, Gilberto Marcelo Sperandio da Silva, Paula Simplício da Silva, Fernanda Martins Carneiro, Luiz Henrique Conde Sangenis, Roberto Magalhães Saraiva, Sérgio Salles Xavier, Pedro Emmanuel Alvarenga Americano do Brasil, Alejandro Marcel Hasslocher‐Moreno, Andréa Silvestre de Sousa,
The benefit of a cardiac rehabilitation (CR) program for patients with Chagas heart failure (CHF) remains unclear. Therefore, we aimed to investigate the effects of CR for CHF patients.A single-arm pilot study, including 12 patients with CHF, was performed. Patients participated in an 8-month physical exercise intervention, comprising aerobic, strength, and stretching exercises (3 times per week, 60 minutes per session). Nutritional and pharmaceutical counseling were also performed. Functional capacity ( ...
Tópico(s): Cardiovascular Effects of Exercise
2016 - Brazilian Society of Tropical Medicine | Revista da Sociedade Brasileira de Medicina Tropical
Produção Nacional
Revisado por pares
João Carlos Pinto Dias, Alberto Novaes Ramos, Eliane Dias Gontijo, Alejandro O. Luquetti, Maria Aparecida Shikanai‐Yasuda, José Rodrigues Coura, Rosália Morais Tôrres, José Renan da Cunha Melo, Eros Antônio de Almeida, Wilson de Oliveira, Antônio Carlos Silveira, Joffre Marcondes de Rezende, Fabiane Scalabrini Pinto, Antônio Walter Ferreira, Anis Rassi, Abílio Augusto Fragata Filho, Andréa Silvestre de Sousa, Dalmo Correia, Ana María Jansen, Gláucia Manzan Queiroz de Andrade, Constança Britto, Ana Yecê das Neves Pinto, Anis Rassi, Dayse Elisabeth Campos, Fernando Abad‐Franch, Silvana Eloi Santos, Égler Chiari, Alejandro Marcel Hasslocher‐Moreno, Eliane Furtado Moreira, Divina Seila de Oliveira Marques, Eliane Lages Silva, José Antônio Marin‐Neto, Lúcia Maria da Cunha Galvão, Sérgio Salles Xavier, Sebastião Aldo da Silva Valente, Noêmia Barbosa Carvalho, Alessandra Viana Cardoso, Rafaella Albuquerque e Silva, Veruska Maia da Costa, Simone Monzani Vivaldini, Suelene Mamede Oliveira, Vera da Costa Valente, Mayara Maia Lima, Renato Vieira Alves,
Chagas disease is a neglected chronic condition with a high burden of morbidity and mortality. It has considerable psychological, social, and economic impacts. The disease represents a significant public health issue in Brazil, with different regional patterns. This document presents the evidence that resulted in the Brazilian Consensus on Chagas Disease. The objective was to review and standardize strategies for diagnosis, treatment, prevention, and control of Chagas disease in the country, based ...
Tópico(s): Trypanosoma species research and implications
2016 - Brazilian Society of Tropical Medicine | Revista da Sociedade Brasileira de Medicina Tropical
Produção Nacional
Revisado por pares
Adriana Campos Junqueira de Souza, Gil F. Salles, Alejandro Marcel Hasslocher‐Moreno, Andréa Silvestre de Sousa, Pedro Emmanuel Alvarenga Americano do Brasil, Roberto Magalhães Saraiva, Sérgio Salles Xavier,
Sudden death is the most frequent mechanism of death in patients with chronic Chaga's cardiopathy, regardless of the degree of myocardial involvement. We developed a model to predict the risk of sudden death in patients with chronic Chaga's cardiopathy.We retrospectively evaluated 373 patients. The association between the risk factors for chronic Chaga's cardiopathy and sudden death was assessed using Cox proportional-hazards analysis, and a risk score was determined. Receiver operating characteristic ( ...
Tópico(s): Cardiovascular Function and Risk Factors
2015 - Elsevier BV | International Journal of Cardiology
Produção Nacional
Revisado por pares
Gilberto Marcelo Sperandio da Silva, Mauro Felippe Felix Mediano, Pedro Emmanuel Alvarenga Americano do Brasil, Mayara da Costa Chambela, Joyce Almeida da Silva, Andréa Silvestre de Sousa, Sérgio Salles Xavier, Andréa Rodrigues da Costa, Roberto Magalhães Saraiva, Alejandro Marcel Hasslocher‐Moreno,
Benznidazole (BZN) is the main trypanocidal drug used to treat Chagas disease, and the evidence supporting the benefits of BZN use during the chronic phase of the disease will favor its use in millions of individuals. However, more than 30% of patients treated with BZN may suffer adverse drug reactions (ADRs), and the development of tools to identify those patients at risk is highly desirable. In the present study, we aimed to identify predictive factors for ADRs in Chagas disease patients treated ...
Tópico(s): Research on Leishmaniasis Studies
2014 - American Society for Microbiology | Antimicrobial Agents and Chemotherapy
Produção Nacional
Revisado por pares
Pedro Emmanuel Alvarenga Americano do Brasil, Andréa Pereira de Souza, Alejandro Marcel Hasslocher‐Moreno, Sérgio Salles Xavier, Sônia Regina Lambert Passos, Maria de Fátima Ramos Moreira, Marília Santini de Oliveira, Gilberto Marcelo Sperandio da Silva, Roberto Magalhães Saraiva, Cláudia Santos de Aguiar Cardoso, Andréa Silvestre de Sousa, Mauro Felippe Felix Mediano, Maria da Gloria Bonecini de Almeida, Otacílio C. Moreira, Constança Britto, Tânia Cremonini de Araújo-Jorge,
Heart disease progression occurs in 30% of patients with chronic Trypanosoma cruzi infection. Supplementation with selenium (Se) in animal model of T. cruzi infection produced promising results. There is evidence that patients with Chagas heart disease have lower Se levels than healthy individuals and patients with T. cruzi infection without of cardiac disease. The aim of this investigation is to estimate the effect of Se treatment on prevention of heart disease progression in patients with chagasic ...
Tópico(s): Trypanosoma species research and implications
2014 - Springer Science+Business Media | Trials
Produção Nacional
Revisado por pares
Fernanda de Souza Nogueira Sardinha Mendes, Jacob Atié, Marcelo Iório Garcia, Eliza de Almeida Gripp, Andréa Silvestre de Sousa, Luiz Augusto Feijó, Sérgio Salles Xavier,
Fundamento: Estudos sobre fibrilação atrial (FA) na insuficiência cardíaca descompensada (ICD) são muito escassos no Brasil
Tópico(s): Heart Failure Treatment and Management
2014 - Sociedade Brasileira de Cardiologia (SBC) | Arquivos Brasileiros de Cardiologia
Produção Nacional
Revisado por pares
Cesar Augusto S. Nascimento, Victor Augusto M. Gomes, Sabrina K. Silva, Carla Renata F. Santos, Mayara C Chambela, Fabiana S Madeira, Marcelo Teixeira de Holanda, Pedro Emmanuel Alvarenga Americano do Brasil, Andréa Silvestre de Sousa, Sérgio Salles Xavier, Alejandro Marcel Hasslocher‐Moreno, Ademir Batista da Cunha, Roberto Magalhães Saraiva,
BackgroundLeft atrial (LA) and left ventricular (LV) diastolic function analysis can yield new strategies to recognize early cardiac involvement and prognostic indicators in Chagas disease.MethodsPatients with Chagas disease with the indeterminate (n = 69) or with the cardiac form (32 with changes limited to electrocardiography [stage A], 25 with changes in LV systolic function but no heart failure [HF; stage B], and 26 with HF) underwent evaluation of LV diastolic function (mitral inflow, pulmonary vein ...
Tópico(s): Cardiovascular Function and Risk Factors
2013 - Elsevier BV | Journal of the American Society of Echocardiography