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Artigo Acesso aberto Revisado por pares

Gianmaria Bonari, Edy Fantinato, Lorenzo Lazzaro, Marta Gaia Sperandii, Alicia Teresa Rosario Acosta, Marina Allegrezza, Silvia Assini, Marco Caccianiga, Valter Di Cecco, Annarita Frattaroli, Daniela Gigante, Giovanni Rivieccio, Giulio Tesei, Barbara Valle, Daniele Viciani, Giulia Albani Rocchetti, Claudia Angiolini, Emilio Badalamenti, Davide Barberis, Matteo Barcella, Giuseppe Bazan, Andrea Bertacchi, Rossano Bolpagni, Federica Bonini, Alessandro Bricca, Gabriella Buffa, Mariasole Calbi, Silvia Cannucci, Luigi Cao Pinna, Maria Carmela Caria, Emanuela Carli, Silvia Cascone, Mauro Casti, Bruno Enrico Leone Cerabolini, R. Copiz, Maurizio Cutini, Leopoldo de Simone, Andrea De Toma, Michele Dalle Fratte, Luciano Di Martino, Romeo Di Pietro, Leonardo Filesi, Bruno Foggi, Paola Fortini, Roberto Gennaio, Gabriele Gheza, Michele Lonati, Andrea Mainetti, Marco Malavasi, Corrado Marcenò, Carla Micheli, Chiara Minuzzo, Michele Mugnai, Carmelo María Musarella, Francesca Napoleone, Ginevra Nota, Giovanna Piga, Marco Pittarello, Ilaria Pozzi, Safiya Praleskouskaya, Francesco Rota, Giacomo Santini, Simona Sarmati, Alberto Selvaggi, Giovanni Spampinato, Adriano Stinca, Francesco Pio Tozzi, Roberto Venanzoni, Mariacristina Villani, Katia Zanatta, Magda Zanzottera, Simonetta Bagella,

Habitat monitoring in Europe is regulated by Article 17 of the Habitats Directive, which suggests the use of typical species to habitat conservation status. Yet, the Directive uses the term “typical” species but does not provide a definition, either for its use in reporting or for its use in impact assessments. To address the issue, an online workshop was organized by the Italian Society for Vegetation Science (SISV) to shed light on the diversity of perspectives regarding the different concepts ...

Tópico(s): Mediterranean and Iberian flora and fauna

2021 - Pensoft Publishers | Plant Sociology

Artigo Revisado por pares

Zhengyi Hu, Zhihui Yang, Chengkai Xu, Silvia Haneklaus, Zhihong Cao, Ewald Schnug,

The effect of plant growth on the mineralization of organic matter and distribution of soil S fractions (plant available SO42—, adsorbed SO42—, carbon-bonded S, ester-bonded S, and residual-S) in the rhizosphere was studied in a greenhouse experiment using a rhizobag technique. In this study wheat, oilseed rape and radish were grown on two soils, a Haplic Acrisol and a Hortic Anthrosol. Significant differences between S fractions in the rhizosphere and non-rhizosphere were determined in dependence ...

Tópico(s): Heavy metals in environment

2002 - Wiley | Journal of Plant Nutrition and Soil Science

Revisão Acesso aberto Revisado por pares

Erik O. Pettersen, Peter Ebbesen, Roben G. Gieling, Kaye J. Williams, Ludwig J. Dubois, Philippe Lambin, Carol Ward, James Meehan, Ian Kunkler, Simon P. Langdon, Anne Hansen Ree, Kjersti Flatmark, Heidi Lyng, Marı́a J. Calzada, Luis del Peso, Manuel O. Landázuri, Agnes Görlach, Hubert Flamm, Jochen Kieninger, G. Urban, Andreas Weltin, Dean C. Singleton, Syed Haider, Francesca M. Buffa, Adrian L. Harris, Andrea Scozzafava, Claudiu T. Supuran, Isabella Moser, G. Jobst, Morten Busk, Kasper Toustrup, Jens Overgaard, Jan Alsner, Jacques Pouysségur, Johanna Chiche, Nathalie M. Mazure, Ibtissam Marchiq, Scott K. Parks, Afshan Ahmed, Margaret Ashcroft, Silvia Pastoreková, Yihai Cao, Kasper M.A. Rouschop, Bradly G. Wouters, Marianne Koritzinsky, Hilda Mujčić, Dan Cojocari,

The hypoxic areas of solid cancers represent a negative prognostic factor irrespective of which treatment modality is chosen for the patient. Still, after almost 80 years of focus on the problems created by hypoxia in solid tumours, we still largely lack methods to deal efficiently with these treatment-resistant cells. The consequences of this lack may be serious for many patients: Not only is there a negative correlation between the hypoxic fraction in tumours and the outcome of radiotherapy as ...

Tópico(s): Cancer Research and Treatments

2014 - Taylor & Francis | Journal of Enzyme Inhibition and Medicinal Chemistry

Artigo Acesso aberto Revisado por pares

Shikai Hu, Jacquelyn O. Russell, Silvia Liu, Catherine Cao, Jackson McGaughey, Ravi Rai, Karis Kosar, Junyan Tao, Edward Hurley, Minakshi Poddar, Sucha Singh, Aaron Bell, Donghun Shin, Reben Raeman, Aatur D. Singhi, Kari Nejak‐Bowen, Sungjin Ko, Satdarshan P. Monga,

Expansion of biliary epithelial cells (BECs) during ductular reaction (DR) is observed in liver diseases including cystic fibrosis (CF), and associated with inflammation and fibrosis, albeit without complete understanding of underlying mechanism. Using two different genetic mouse knockouts of β-catenin, one with β-catenin loss is hepatocytes and BECs (KO1), and another with loss in only hepatocytes (KO2), we demonstrate disparate long-term repair after an initial injury by 2-week choline-deficient ethionine- ...

Tópico(s): Pediatric Hepatobiliary Diseases and Treatments

2021 - eLife Sciences Publications Ltd | eLife

Artigo Revisado por pares

Derong Cao, Silvia Dobis, Chunmei Gao, Sabine Hillmann, Herbert Meier,

Dendrimers 6G(i) (i=1-4) consisting of an anthracene core and Fréchet dendrons which are attached via a CH(2)OCH(2) chain in the 9-position undergo quantitative and completely reversible intramolecular [4pi+4pi] cycloaddition. The process can be monitored by absorption and fluorescence measurements. The Fréchet dendrons act as an energy funnel that collects and focuses the photon energy but does not change the photostationary states, which for both directions are completely on the product side when ...

Tópico(s): Organic Electronics and Photovoltaics

2007 - Wiley | Chemistry - A European Journal

Artigo Revisado por pares

Daniel A. Jacobo‐Velázquez, Ginés Benito Martínez–Hernández, Silvia Rodríguez, Cong-Mei Cao, Luis Cisneros‐Zevallos,

Plants subjected to postharvest abiotic stresses synthesize secondary metabolites with health-promoting properties. Here, we report the potential use of carrots (Daucus carota) as biofactories of caffeoylquinic acids when subjected to wounding and hyperoxia stresses. Wounding stress induced an increase of ∼287% in total phenolic content (PC) in carrots stored for 48 h at 20 °C. This increase was higher (∼349%) in the wounded tissue treated with hyperoxia stress. To further understand the physiological ...

Tópico(s): Antioxidant Activity and Oxidative Stress

2011 - American Chemical Society | Journal of Agricultural and Food Chemistry

Artigo Revisado por pares

Yang Cao, Sílvia Osuna, Yong Liang, Robert C. Haddon, K. N. Houk,

The cycloaddition reactions and noncovalent π interactions of 2,3-dimethoxybutadiene (DMBD), 9-methylanthracene (MeA), tetracyanoethylene (TCNE), and maleic anhydride (MA) with graphene models have been investigated using density functional theory (DFT) calculations. Reaction enthalpies have been obtained to assess the reactivity and selectivity of covalent and noncovalent functionalization. Results indicate that graphene edges may be functionalized by the four reagents through cycloaddition reactions, ...

Tópico(s): History and advancements in chemistry

2013 - American Chemical Society | Journal of the American Chemical Society

Artigo Acesso aberto Revisado por pares

María Dolores Arenas, Judit Villar, Cristina González, Higinio Cao, Sílvia Collado, Marta Crespo, Juan Pablo Horcajada, Julio Pascual,

La epidemia de SARS-CoV-2 representa un riesgo especial para los pacientes renales por su condición de personas con comorbilidades y edad avanzada, y por la realización del tratamiento de hemodiálisis en salas colectivas. La información específica en el momento actual al respecto es muy limitada. El presente manuscrito recoge una propuesta de actuación para prevenir la infección en los Servicios de Nefrología, y en particular en las unidades de hemodiálisis, con el objetivo de identificar precozmente ...

Tópico(s): SARS-CoV-2 and COVID-19 Research

2020 - Elsevier BV | Nefrología

Artigo Acesso aberto Revisado por pares

Li Xue, Zhi Cao, Silvia Scherhaufer, Karin Östergren, Shengkui Cheng, Gang Liu,

Abstract Tomato and tomato products are the most consumed vegetables worldwide. However, reduction of their relatively high emission intensity can be a key to mitigating greenhouse gas (GHG) emissions of the agrifood sector. Using the European Union (EU) and its 28 member states as example, we mapped the mass flow and analyzed the efficiency of the entire tomato supply chain from farm to fork for the year 2016. We then explored potentials of a full spectrum of GHG emission mitigation strategies ranging ...

Tópico(s): Agriculture Sustainability and Environmental Impact

2020 - Wiley | Journal of Industrial Ecology

Artigo Revisado por pares

Elisabetta Ruggeri, Doyoon Kim, Yunteng Cao, Silvia Farè, Luigi De Nardo, Benedetto Marelli,

In this study, a new edible coating material with enhanced mechanical and gas barrier properties was studied by coupling silk fibroin (SF) with poly(vinyl alcohol) (PVOH). SF and PVOH water suspensions were mixed at different ratios to form multilayered membranes that, after a phase separation, assembled on the surface of fresh-cut produce upon dip coating. The effects of the mixing ratio on transparency, mechanical properties, water vapor, and oxygen permeability of the films were investigated. Higher ...

Tópico(s): Conducting polymers and applications

2020 - American Chemical Society | ACS Sustainable Chemistry & Engineering

Artigo Acesso aberto Revisado por pares

María Dolores Arenas, Judit Villar, Cristina González, Higinio Cao, Sílvia Collado, Marta Crespo, Juan Pablo Horcajada, Julio Pascual,

The current outbreak of SARS-CoV-2 represents a special risk for renal patients due to their comorbidities and advanced age. The usual performance of hemodialysis treatment s in collective rooms increases the risk. The specific information at this time in this regard is very limited. This manuscript includes a proposal for action to prevent infection in the Nephrology Services, and in particular in hemodialysis units, with the objective of early identification of patients who meet the definition ...

Tópico(s): SARS-CoV-2 and COVID-19 Research

2020 - Elsevier BV | Nefrología (English Edition)

Artigo Revisado por pares

Adalberto Miranda‐Filho, Joannie Lortet‐Tieulent, Freddie Bray, Bochen Cao, Silvia Franceschi, Salvatore Vaccarella, Luigino Dal Maso,

Summary Background The incidence of thyroid cancer has increased in different populations worldwide in the past 30 years. We present here an overview of international trends of thyroid cancer incidence by major histological subtypes. Methods We did a population-based study with data for thyroid cancer incidence collected by the International Agency for Research on Cancer (IARC) for the period 1998–2012. Data were extracted from the Cancer Incidence in Five Continents plus compendium. We selected data for ...

Tópico(s): Radiomics and Machine Learning in Medical Imaging

2021 - Elsevier BV | The Lancet Diabetes & Endocrinology

Artigo Acesso aberto Revisado por pares

José M. Porcel, Manuel Vives, Guoqiang Cao, Silvia Bielsa, Agustín Ruiz‐González, Alicia Martínez-Iribarren, Aureli Esquerda,

We aimed to investigate whether pleural fluid concentrations of biomarkers for bacterial infection, namely triggering receptor expressed on myeloid cells (sTREM-1), procalcitonin (PCT), lipopolysaccharide-binding protein (LBP) and C-reactive protein (CRP), might identify infectious effusions and discriminate between complicated (CPPEs) and uncomplicated parapneumonic effusions (UPPEs). Stored pleural fluid samples from 308 patients with different causes of pleural effusion were used to measure the four ...

Tópico(s): Respiratory Support and Mechanisms

2009 - European Respiratory Society | European Respiratory Journal

Artigo Revisado por pares

José M. Porcel, Montserrat Martínez‐Alonso, Gonzalo Cao, Silvia Bielsa, Ana Sopena, Aureli Esquerda,

Background The objective of this study was to compare the diagnostic accuracy of pleural fluid brain natriuretic peptide (BNP), N-terminal pro-BNP (NT-pro-BNP) and ST2, which are biomarkers of myocyte stress, for diagnosing pleural effusions due to heart failure (HF). BNP and ST2 have not been previously evaluated in pleural fluid. Methods The three biomarkers were measured in the pleural fluid of 90 cardiac effusions and 91 noncardiac effusions by commercially available methodologies. The area under ...

Tópico(s): Heart Failure Treatment and Management

2009 - Elsevier BV | CHEST Journal

Artigo Revisado por pares

Maria Cristina Rosatelli, Alessandra Pischedda, Alessandra Meloni, L. Saba, A Pomo, Maurizio Travi, Silvia Fattore, Antonio Cao,

This paper describes the phenotypic manifestations of a very mild beta-thalassaemia mutation detected in several members of two families of Italian descent. The molecular defect, defined by denaturing gradient gel electrophoresis analysis and direct sequencing, consists of a C-->G substitution at position 844 of IVSII of the beta-globin gene within the consensus sequence of the IVSII acceptor splice site. Heterozygotes for this mutation show a haematological phenotype ranging in severity from silent ...

Tópico(s): Blood groups and transfusion

1994 - Wiley | British Journal of Haematology

Artigo Acesso aberto Revisado por pares

Olha Kostiuchenko, N. A. Kravchenko, Ján Markus, Stephen Burleigh, Olexandr Fedkiv, Ling Cao, Silvia Letašiová, G. G. Skibo, Frida Fåk Hållenius, Olena Prykhodko,

Cysteine proteases obtained from the stem of pineapple or papaya latex, bromelain and papain, respectively, exhibit a broad spectrum of beneficial effects on human health. However, their effects on gut microbiota composition or dose-manner effects on the intestinal integrity of healthy tissue have not been evaluated. In this study, C57BL/6 young, healthy mice were fed bromelain or papain in a dose of 1 mg per animal/day for three consecutive days, followed by the assessment of digestive protein ...

Tópico(s): Pineapple and bromelain studies

2022 - Multidisciplinary Digital Publishing Institute | Metabolites

Artigo Acesso aberto Revisado por pares

Paola Losi, Luisa Mancuso, Tamer Al Kayal, Simona Celi, Enrica Briganti, Alice Gualerzi, Silvia Volpi, Giacomo Cao, Giorgio Soldani,

The capacity of a composite vascular graft constituting polyurethane (PU) and gelatin to support cell growth was investigated using human mesenchymal stem cells (hMSCs). Gelatin-based polyurethane grafts were fabricated by co-spraying polyurethane and gelatin using a spray, phase-inversion technique. Graft microstructure was investigated by light and scanning electron microscopy. Uniaxial tensile tests were performed to assess the grafts' mechanical properties in longitudinal and circumferential directions. ...

Tópico(s): Polymer Surface Interaction Studies

2015 - IOP Publishing | Biomedical Materials

Artigo Revisado por pares

Giovanni Monni, Rosa Maria Ibba, Rosalba Laj, Cau Giuseppina, Mura Silvia, Giovanni Olla, Antonio Cao,

In this paper we report the fetal loss rate in relation to both maternal and gestational age in 1764 pregnant women who underwent transabdominal chorionic villus sampling (TA-CVS) between January 1986 and August 1990. The fetal loss rate, considered as a proportion of continuing pregnancies, decreased with advancing gestational age at sampling from 4.3 per cent before 9 weeks to 0.4 per cent at or after 13 weeks, the difference being statistically significant (p <0.025). The fetal loss rate increased ...

Tópico(s): Parvovirus B19 Infection Studies

1992 - Wiley | Prenatal Diagnosis

Artigo Acesso aberto Revisado por pares

Yupeng Li, Bin Ma, Qing Cao, Silvia Balbo, Lijiao Zhao, Pramod Upadhyaya, Stephen S. Hecht,

The tobacco-specific carcinogens N′-nitrosonornicotine (NNN) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) require metabolic activation to exert their carcinogenicity. NNN and NNK are metabolized to the same reactive diazonium ions, which alkylate DNA forming pyridyloxobutyl (POB) DNA base and phosphate adducts. We have characterized the formation of both POB DNA base and phosphate adducts in NNK-treated rats and the formation of POB DNA base adducts in NNN-treated rats. However, POB DNA ...

Tópico(s): Cancer therapeutics and mechanisms

2019 - American Chemical Society | Chemical Research in Toxicology

Artigo Revisado por pares

Miquel Blasco, Borja Quiroga, José Manuel García‐Aznar, Cristina Castro-Alonso, Saulo J. Fernández-Granados, Enrique Luna, Gema Fernández Fresnedo, Marta Ossorio, María Jesús Izquierdo, Didier Sánchez-Ospina, Laura Castañeda-Infante, Ricardo Mouzo, Mercedes Cao, María Lara Besada-Cerecedo, Ricardo Pan-Lizcano, Roser Torrá, Alberto Ortíz, Patricia de Sequera, Victoria E Garcia Montemayor, Mercedes Salgueira Lazo, Auxiliadora Mazuecos Blanca, Tamara Jiménez Salcedo, María José Espigares Huete, Elena Araceli Jiménez Vibora, Concepción Álamo Caballero, Eduardo Josué Banegas Derás, Alejandro Alonso Bethencourt, Ángel A. García, Saulo Fernández Granados, Gema Fernández Fresnedo, Leonardo Calle García, Jesús Martín García, Jorge Estifan Kasabji, María Jesús Izquierdo, Ricardo Mouzo Mirco, Rebeca García-Agudo, Gabriel de Arriba, Carme Facundo Molas, Marc Xipell Font, Alejandra Yugueros González, Paula Antóns, Meritxell Ibernon Vilaro, Vanessa de la Fuente Fernández, Yariel González Galván, Antonio Cabezas, Cristina Castro Alonso, Isabel Juan García, Eduardo Garín Cascales, J. Morant, Enrique Luna Complejo, Rosa María Díaz Campillejo, Silvia González Sanchidrián, Mercedes Cao Vilariño Complejo, Milagros Sierra Carpio, Mayra Ortega Díaz, Rosa Sánchez Hernández, Marta Ossorio González, Almudena Vega Martínez, M Picasso, Elena Gomá-Garcés, Martín Giorgi, Patricia Martínez‐Miguel, Eduardo Gutiérrez Martínez, Vicente Paraíso Cuevas, Rocío Echarri, Víctor Martínez, Mireia Arnedo, L Infante, Jose Antonio Menacho Miguel,

Rationale & Objective Chronic kidney disease (CKD) of unknown etiology (CKDUE) is one of the main global causes of kidney failure. While genetic studies may identify an etiology in these patients, few studies have implemented genetic testing of CKDUE in population-based series of patients which was the focus of the GENSEN. Study Design Case series. Settings & Participants 818 patients aged ≤45 years at 51 Spanish centers with CKDUE, and either an estimated GFR <15 mL/min/1.73 m2 or treatment with maintenance ...

Tópico(s): Chronic Kidney Disease and Diabetes

2024 - Elsevier BV | American Journal of Kidney Diseases

Artigo Acesso aberto Revisado por pares

Silvia Giulio, Luigi Cao Pinna, Marta Carboni, Flavio Marzialetti, Alicia Teresa Rosario Acosta,

Many invasive plants are threatening the already highly vulnerable habitats of coastal dunes in Europe. Setting priority target species to control is mandatory for an effective planning of invasion management strategies at European level. This can be possible after identifying the species that currently have greater invasion success, in consideration of their ecological traits and origin. We quantified the three main components of invasion success for the extra-European alien plants found on European ...

Tópico(s): Plant and animal studies

2021 - Pensoft Publishers | Plant Sociology

Artigo Acesso aberto Revisado por pares

María Dolores Arenas, Judit Villar, Cristina González, Higinio Cao, Sílvia Collado, Francesc Barbosa, Marta Crespo, Juan Pablo Horcajada, Julio Pascual,

The COVID-19 epidemic represents a special risk for kidney patients due to their comorbidities and advanced age, and the need for hemodialysis treatment in group rooms. It also represents a risk for professionals responsible for their attention. This manuscript contains a proposal for action to prevent infection of professionals in the Nephrology Services, one of the most valuable assets at the present time. La epidemia de COVID-19 representa un riesgo especial para los pacientes renales por sus ...

Tópico(s): COVID-19 and Mental Health

2020 - Elsevier BV | Nefrología (English Edition)

Artigo Acesso aberto Revisado por pares

María José Pérez‐Sáez, Carlos Arias-Cabrales, Dolores Redondo‐Pachón, Carla Burballa, Anna Buxeda, Anna Sofie Bach, Anna Faura, Ernestina Junyent, Ester Marco, Leocadio Rodrı́guez-Mañas, Marta Crespo, Julio Pascual, María José Pérez‐Sáez, Carlos Arias-Cabrales, Dolores Redondo‐Pachón, Francesc Barbosa, Higini Cao, Sílvia Collado, Anna Buxeda, Carla Burballa, Marta Crespo, Julio Pascual, Anna Faura, María Vera, Anna Sofie Bach, Guillermo Pedreira, Ernestina Junyent, Montserrat Folgueiras, Yolanda del Carmen Moreno Castillo, Aida Aleyda Jiménez Martínez, Marisol Fernández, Eva Barbero, Rosa Causadías, Jesús Carazo, Lluís Cecchini, Ester Marco, Delky Meza de Valderrama, Andrea Morgado, Elena Muñoz, Xavier Nogués, Leocadio Rodrı́guez-Mañas, Olga Castro, María Dolores Muns, Miguel Gárriz, María Polo Gómez, Sara Hurtado, Maite López-Sánchez, Laura Ribera, Margarita Guino, Ramón Roca‐Tey, Jordi Calls, Alicia Rovira, Josep Ferrater Mora, Omar Ibrik, Florentina Liria, Thais Torralbo Lopez-Capp, Jaume Almirall, Carmen Moya, Fátima Moreno, Manel Ramírez de Arellano, Sandra Rubio, Ignacio Cidraque, Carlota Pájaro, Núria Garra, Josep Galcerán, Marina Fenollar, Sara Outón, Fabiola Dapena, Josep Jara, Rosa Garcı́a, Mònica Manresa,

ABSTRACT Background Physical Frailty Phenotype (PFP) is the most used frailty instrument among kidney transplant recipients, classifying patients as pre-frail if they have 1–2 criteria and as frail if they have ≥3. However, different definitions of robustness have been used among renal patients, including only those who have 0 criteria, or those with 0–1 criteria. Our aim was to determine the impact of one PFP criterion on transplant outcomes. Methods We undertook a retrospective study of 296 kidney ...

Tópico(s): Renal Transplantation Outcomes and Treatments

2022 - Oxford University Press | Clinical Kidney Journal

Artigo Acesso aberto Revisado por pares

Xiaodong Wu, Megumu Yamada-Mabuchi, Erick J. Morris, Pradeep S. Tanwar, Leonard L. Dobens, Silvia Gluderer, Sabina Khan, Jing Cao, Hugo Stocker, Ernst Hafen, Nick Dyson, Laurel A. Raftery,

TSC22D1, which encodes transforming growth factor beta-stimulated clone 22 (TSC-22), is thought to be a tumor suppressor because its expression is lost in many glioblastoma, salivary gland, and prostate cancers. TSC-22 is the founding member of the TSC-22/DIP/Bun family of leucine zipper transcription factors; its functions have not been investigated in a multicellular environment. Genetic studies in the model organism Drosophila melanogaster often provide fundamental insights into mechanisms disrupted ...

Tópico(s): Hippo pathway signaling and YAP/TAZ

2008 - National Academy of Sciences | Proceedings of the National Academy of Sciences

Artigo Acesso aberto Revisado por pares

Siguang Li, Serena Sanna, Andrea Maschio, Fabio Busonero, Gianluca Usala, Antonella Mulas, Sandra Lai, Mariano Dei, Marco Orrú, Giuseppe Albai, Stefania Bandinelli, David Schlessinger, Edward G. Lakatta, Angelo Scuteri, Samer S. Najjar, Jack M. Guralnik, Silvia Naitza, Laura Crisponi, Antonio Cao, Gonçalo R. Abecasis, Luigi Ferrucci, Manuela Uda, Wei-Min Chen, Ramaiah Nagaraja,

High serum uric acid levels elevate pro-inflammatory–state gout crystal arthropathy and place individuals at high risk for cardiovascular morbidity and mortality. Genome-wide scans in the genetically isolated Sardinian population identified variants associated with serum uric acid levels as a quantitative trait. They mapped within GLUT9, a Chromosome 4 glucose transporter gene predominantly expressed in liver and kidney. SNP rs6855911 showed the strongest association (p = 1.84 × 10−16), along with eight ...

Tópico(s): Eosinophilic Disorders and Syndromes

2007 - Public Library of Science | PLoS Genetics

Artigo Acesso aberto Revisado por pares

Marta Crespo, Sílvia Collado, Marisa Mir, Higini Cao, Francesc Barbosa, Consol Serra, Carlota Hidalgo, Anna Faura, M. Montero, Juan García de Lomas, Juan Pablo Horcajada, Josep Puig, Julio Pascual,

Data are needed to assess safety and efficacy of the 2009 pandemic influenza A H1N1 vaccine in renal patients.We prospectively evaluated seroconversion, predictors of response, and vaccine safety in renal patients. Hemagglutination inhibition tests to detect serum antibodies against a new influenza A-H1N1 virus were performed in 79 transplant patients, 48 hemodialysis patients, and 15 healthy workers before and 1 month after vaccination. Healthy controls and 88 of 127 renal patients were vaccinated. ...

Tópico(s): Respiratory viral infections research

2011 - Lippincott Williams & Wilkins | Clinical Journal of the American Society of Nephrology

Artigo Acesso aberto

Nikki A. Evensen, Yiyi Li, Cem Kuscu, Jingxuan Liu, Jillian Cathcart, Anna Banach, QIAN ZHANG, Ellen Li, Sonia Joshi, Jie Yang, Paula Denoya, Silvia Pastoreková, Stanley Zucker, Kenneth R. Shroyer, Jian Cao,

... 1 , Jie Yang 4 , Paula I Denoya 5 , Silvia Pastorekova 6 , Stanley Zucker 7 , Kenneth R. Shroyer 2 , Jian Cao 1, 2 1 Department of Medicine/Division of ...

Tópico(s): Cancer-related Molecular Pathways

2015 - Impact Journals LLC | Oncotarget

Artigo Acesso aberto Revisado por pares

María Dolores Arenas, Judit Villar, Cristina González, Higinio Cao, Sílvia Collado, Francesc Barbosa, Marta Crespo, Juan Pablo Horcajada, Julio Pascual,

La epidemia de COVID-19 representa un riesgo especial para los pacientes renales por sus comorbilidades y edad avanzada, y por la realización del tratamiento de hemodiálisis en salas colectivas, pero también supone un riesgo para los profesionales responsables de su atención. El presente manuscrito recoge una propuesta de actuación para prevenir la infección entre los profesionales en los Servicios de Nefrología. The COVID-19 epidemic represents a special risk for kidney patients due to their comorbidities ...

Tópico(s): COVID-19 and Mental Health

2020 - Elsevier BV | Nefrología

Capítulo de livro Acesso aberto Revisado por pares

Harvey J. Miller,

... Lenz.- Shared ride trip planning with geosensor networks, Silvia Nittel, Stephan Winter, Arda Nural and Trang Cao.- Section V. Mobile Information Services.- Mobile ICT in ...

Tópico(s): Smart Parking Systems Research

2007 - Springer Nature (Netherlands) | ˜The œGeojournal library

Artigo Acesso aberto Revisado por pares

Roberto Martínez, Gustavo Tapia, Silvia de Muga, Alba Hernández, María González Cao, Cristina Teixidó, Víctor Urrea, Elisabet García, Sònia Pedreño‐López, L. Ibarz, Julià Blanco, Bonaventura Clotet, Cecilia Cabrera,

Intravesical Bacille Calmette-Guérin (BCG) remains the most effective treatment for high-risk non-muscle-invasive bladder cancer (NMIBC), unfortunately there is no validated biomarker to predict clinical outcome. Here we tried to explore the possibility that a combination of the density of peritumoral infiltrating cells (Th1, Th2 and PD-L1) and the composition of peripheral immune cells (neutrophil and lymphocyte counts) could generate a more reliable prognostic biomarker. Twenty-two patients with high- ...

Tópico(s): Inflammatory Biomarkers in Disease Prognosis

2019 - Landes Bioscience | OncoImmunology