Tópico(s): Political Theory and Democracy
1989 - | Estudios Públicos
Frédéric Dolle, Charles Hétru, Jean‐Pierre Roussel, B. Rousseau, Franck Sobrio, Bang Luu, Jean‐Sébastien Hoffmann,
We have synthesized a tritiated form of 14α-hydroxy-β-cholest-7-ene-3,6-dione (5β-diketol) of high specific activity (1.74 TBq/mmol) from 7-dehydrocholesterol in seven steps with stereoselective introduction of the A/B cis ring junction as the key reaction. We have examined the ability of endocrine glands (prothoracic glands) of Locusta migratoria to use this molecule as a precursor of 3-dehydroecdysone and of ecdysone biosynthesis. A very efficient conversion of 5β-diketol to ecdysone and to 3-dehydroecdysone ...
Tópico(s): Insect and Arachnid Ecology and Behavior
1991 - Elsevier BV | Tetrahedron
Danièle Debruyne, Franck Sobrio, Antoine Hinschberger, R. Camsonne, Antoine Coquerel, Louisa Barré,
As a preliminary to development and evaluation of labeled mecamylamine as a potential in vivo imaging ligand for human central nicotinic receptors (nAchRs), this work was intended to determine whether the pharmacokinetic properties of mecamylamine are suitable for experimental studies using 11C-radiolabeled mecamylamine preliminary to positron emission tomography (PET) in humans. An original gas chromatographic method for rapid and simple determination of mecamylamine in biological samples was developed ...
Tópico(s): Cholinesterase and Neurodegenerative Diseases
2003 - Elsevier BV | Journal of Pharmaceutical Sciences
Laurent Lemoucheux, Jacques Rouden, Méziane Ibazizène, Franck Sobrio, Marie‐Claire Lasne,
Efficient and rapid preparations of carbamoyl chlorides and unsymmetrical ureas from tertiary amines and phosgene or its safe equivalent triphosgene [bis(trichloromethyl)carbonate, BTC] are described. First, the reaction of stoichiometric amounts of phosgene with secondary amines was revisited, and it was shown that the formation of carbamoyl chlorides in high yields required careful adjustments of experimental conditions and the use of pyridine as an HCl scavenger. A phosgene-mediated dealkylation ...
Tópico(s): Chemical Synthesis and Analysis
2003 - American Chemical Society | The Journal of Organic Chemistry
Nicolas Aide, Olivier Cappele, P Bottet, H. Bensadoun, Armelle Regeasse, F. Comoz, Franck Sobrio, G�rard Bouvard, Denis Agostini,
Tópico(s): Medical Imaging Techniques and Applications
2003 - Springer Science+Business Media | European Journal of Nuclear Medicine and Molecular Imaging
Produção Nacional
Revisado por pares
Mário Sérgio Ribeiro, Luíz Cláudio Ribeiro, Marcondes Antunes Garcia, Grazielle Fialho de Souza, Karolina Danielle Carvalho de Sousa, Rachel Bueno Nogueira,
... familiar; sentir-se auto-suficiente, expansivo, insatisfeito quando sóbrio; sentir-se auto-suficiente ou conformado quando alcoolizado; ...
Tópico(s): Behavioral Health and Interventions
2008 - UNIVERSIDADE FEDERAL DO RIO DE JANEIRO | Jornal Brasileiro de Psiquiatria
Patrice Marchand, Christophe Lorilleux, Gwénaëlle Gilbert, Fabienne Gourand, Franck Sobrio, Damien Peyronnet, Martine Dhilly, Louisa Barré,
An efficient method to incorporate the fluorine-18 radionuclide in 2-nitropurine-based nucleosides was developed. The nucleophilic radiofluorination of the labeling precursor with [(18)F]KF under aminopolyether-mediated conditions (Kryptofix 2.2.2/K2CO3) followed by deprotection was straightforward and, after formulation, gave 2-[(18)F]fluoroadenosine, ready for injection with a radiochemical yield of 45 ± 5%, a radiochemical purity of >98%, and a specific radioactivity up to 148 GBq/μmol. A micropositron ...
Tópico(s): Polyomavirus and related diseases
2010 - American Chemical Society | ACS Medicinal Chemistry Letters
Franck Sobrio, Gwénaëlle Gilbert, Cécile Perrio, Louisa Barré, D. Debruyne,
Imaging the N-methyl-D-aspartate receptors (NMDARs) in the living human brain by positron emission tomography (PET) or single photon emission computed tomography (SPECT) would provide useful information on the role of these receptors in ischemia and in various neurological disorders such as degenerative diseases, epilepsy or schizophrenia. To assess NMDAR radiotracer development and to propose perspectives, we overviewed the PET and SPECT candidate radioligands developed until now. Labelled molecules ...
Tópico(s): Chemical Synthesis and Analysis
2010 - Bentham Science Publishers | Mini-Reviews in Medicinal Chemistry
Samuel Valable, Edwige Petit, Simon Roussel, Léna Marteau, Jérôme Toutain, Didier Divoux, Franck Sobrio, Jérôme Delamare, Louisa Barré, Myriam Bernaudin,
No direct proof has been brought to light in a link between hypoxic changes in glioma models and the effects of antiangiogenic treatments. Here, we assessed the sensitivity of the detection of hypoxia through the use of (18)F-fluoromisonidazole positron emission tomography ([(18)F]-FMISO PET) in response to the evolution of the tumor and its vasculature.Orthotopic glioma tumors were induced in rats after implantation of C6 or 9L cells. Sunitinib was administered from day (D) 17 to D24. At D17 and D24, ...
Tópico(s): MRI in cancer diagnosis
2011 - Elsevier BV | Nuclear Medicine and Biology
... programa (Harris 1978). Mais recentemente, num tom mais sobrio, Eric Wolf sugeriu que o campo da antropologia ...
Tópico(s): Indigenous Studies in Latin America
2011 - UNIVERSIDADE FEDERAL DO RIO DE JANEIRO | Mana
Romain Labas, Gwénaëlle Gilbert, Olivier Nicole, Martine Dhilly, Ahmed Abbas, O. Tirel, Alain Buisson, Joël Henry, Louisa Barré, Danièle Debruyne, Franck Sobrio,
In this study, novel specific PET radioligands containing the 4-(4-fluorobenzyl)piperidine moiety and selectively antagonistic for the NR2B subunit containing NMDA receptors were developed. Two antagonists, RGH-896 (1a) and 4-(4-fluorobenzyl)piperidinyl-1-methyl-2-benzimidazol-5-ol (2a), belonging to two different structural families, were radiolabeled by an aromatic nucleophilic radiofluorination followed by a reduction of the para-position carbonyl function. Radiotracers [18F]1a, [18F]2a or the pattern ...
Tópico(s): Molecular Sensors and Ion Detection
2011 - Elsevier BV | European Journal of Medicinal Chemistry
Radouane Koudih, Gwénaëlle Gilbert, Martine Dhilly, Ahmed Abbas, Louisa Barré, Danièle Debruyne, Franck Sobrio,
Diastereoisomeric compounds [(18)F]cis- and [(18)F]trans-4-methylbenzyl 4-[(pyrimidin-2-ylamino)methyl]-3-fluoro-piperidine-1-carboxylates were successfully synthesized as new subtype-selective PET radiotracers for imaging the NR2B subunit containing NMDA receptors. Rat brain section autoradiographies demonstrated a high specific binding in NR2B/NMDA receptor rich regions for both radioligands. The measured logD(7.4) values as well as B(max)/K(d) ratios indicated that both radiotracers possess the adequate ...
Tópico(s): S100 Proteins and Annexins
2012 - Elsevier BV | European Journal of Medicinal Chemistry
Zhi-Xin Yin, Wei He, Weijian Chen, Jiang-Hui Yan, Junning Yang, Siu‐Ming Chan, Jianguo He,
... alginolyticus, Vibrio vulnificus, Pasturella multocida, Morganella morganii, Aeromonas sobrio, Aeromonas hydrophila, Flavobacterium meningosepticum and Escherichia coli DH5α ( ...
Tópico(s): Invertebrate Immune Response Mechanisms
2005 - Elsevier BV | Aquaculture
Arnaud Halley, Alexis Hugentobler, Philippe Icard, E. Porret, Franck Sobrio, Jean-Philippe Lerochais, G. Bouvard, Gérard Zalcman, Denis Agostini,
Tópico(s): Lung Cancer Treatments and Mutations
2005 - Springer Science+Business Media | European Journal of Nuclear Medicine and Molecular Imaging
Mickaël Huiban, Aline Huet, Louisa Barré, Franck Sobrio, Éric Fouquet, Cécile Perrio,
The 11C-monomethylstannate prepared from [11C]-methyl iodide and Lappert's stannylene, was subject to a palladium-mediated cross-coupling reaction with an aryl halide under ligand-free conditions, to afford easily purified 11C-methyl(hetero)arenes in high radiochemical yields.
Tópico(s): Chemical Reactions and Isotopes
2005 - Royal Society of Chemistry | Chemical Communications
C. Llopis Giménez, M.I. Rodríguez García, I. Hernández Mancha,
... hacia su pareja en mayor proporción en estado sobrio que en estado ebrio.No obstante, el consumo ...
Tópico(s): Criminal Justice and Penology
2014 - SciELO | Cuadernos de Medicina Forense
l ‐Glutamate is the major neurotransmitter in the central nervous system and activates both ionotropic and metabotropic receptors. Here the radiosynthesis of radiotracers developed for both types of receptors are reviewed with a highlight on the radiopharmaceuticals used or evaluated in humans. At first, radiotracers were developed for ionotropic N ‐methyl‐ d ‐aspartate receptors without any success to obtain radiopharmaceuticals useable for clinical or even preclinical positron emission tomography ( ...
Tópico(s): Medical Imaging Techniques and Applications
2013 - Wiley | Journal of Labelled Compounds and Radiopharmaceuticals
Anny Souque, Jérôme Fagart, Brigitte Couette, Elisabeth Davioud–Charvet, Franck Sobrio, A. Marquet, M.E. Rafestin-Oblin,
To investigate the role of the C18 substituents in the agonist/antagonist properties of mineralocorticoids, the activities of certain C18-substituted progesterone (P) derivatives were examined. These compounds were characterized by an unsaturated side-chain in the case of 18-vinylprogesterone (18VP) and 18-ethynylprogesterone (18EP) and by an enone group in the case of 18-oxo-18-vinylprogesterone (18OVP). P and its 18-substituted derivatives bind to the recombinant human MR (hMR) overexpressed in Sf9 ...
Tópico(s): Stress Responses and Cortisol
1995 - Oxford University Press | Endocrinology
Martine Maı̈bèche-Coisné, Franck Sobrio, Thierry Delaunay, Martine Lettéré, Jacqueline Dubroca, Emmanuelle Jacquin‐Joly, Patricia Nagnan‐Le Meillour,
Several isoforms of pheromone-binding proteins (PBP) and general odorant-binding proteins (GOBP) were previously characterized in the antennae of the cabbage armyworm Mamestra brassicae L. (Lepidoptera: Noctuidae). In further investigations, we used two-dimensional electrophoresis and Western-blotting with antibodies raised against the PBPs of the male: this method revealed more proteins with molecular weight and isoelectric points similar to those of OBPs and confirmed the high level of microdiversity ...
Tópico(s): Insect Utilization and Effects
1997 - Elsevier BV | Insect Biochemistry and Molecular Biology
Produção Nacional
Revisado por pares
... senao,e abandonada. As vezes, no entanto, estao sobrios em sua primeira delibera-cao, mas nestes casos, ...
Tópico(s): Game Theory and Voting Systems
1997 - UNIVERSIDADE DE SÃO PAULO | Estudos Avançados
Jonathan D. Bohbot, Franck Sobrio, Philippe Lucas, Patricia Nagnan‐Le Meillour,
A new protocol of binding assay allowed us to functionally characterize two additional odorant-binding proteins in antennae of the mothMamestra brassicae.These proteins have no N-terminal sequence homology with the moth pheromone-binding proteins and general odorant-binding proteins previously described. One of the two proteins designated MbraAOBP2 is between 60 and 73% similar in N-terminal to several proteins characterized in chemosensory organs of Diptera, Hymenoptera, Lepidoptera, and Phasmids, ...
Tópico(s): Insect Utilization and Effects
1998 - Elsevier BV | Biochemical and Biophysical Research Communications
... en esa categoría de libros que realizan un sobrio análisis del presente y se convierten instantáneamente en ...
Tópico(s): Economic and Social Development
2017 - | Theorein Revista de Ciencias Sociales
Alex Gu, Chapman Wei, Camilla M. Maybee, Shane A. Sobrio, Matthew P. Abdel, Peter K. Sculco,
Total knee arthroplasty (TKA) utilization is increasing in older Americans. The incidence of chronic obstructive pulmonary disease (COPD) has been steadily rising over the past few decades. In particular, COPD is being increasingly more common in patients undergoing revision TKA. The aim of this study is to identify the impact of COPD on postoperative complications for patients undergoing revision TKA.A retrospective cohort study was conducted using data collected through the American College of Surgeons ...
Tópico(s): Orthopaedic implants and arthroplasty
2018 - Elsevier BV | The Journal of Arthroplasty
Alex Gu, Chapman Wei, H.N. Robinson, Shane A. Sobrio, Jiabin Liu, Thomas P. Sculco, Peter K. Sculco,
Abstract Total knee arthroplasty (TKA) is a common and effective treatment of knee osteoarthritis. As the amount of TKAs performed increases, so does the number of TKA failures and subsequent revisions. Diabetes mellitus (DM) has been shown to increase complications following orthopaedic procedures. For these reasons, it is important to understand the association between severity of DM and the risk of postoperative adverse events following revision TKA. A retrospective cohort study was conducted using ...
Tópico(s): Orthopedic Infections and Treatments
2019 - Thieme Medical Publishers (Germany) | The Journal of Knee Surgery
Romain Labas, Franck Sobrio, Yann Bramoullé, Anne‐Sophie Hérard, Martine Guillermier, Philippe Hantraye, Frédéric Dollé, Louisa Barré,
Abstract In order to perform in vivo imaging of the NR2B NMDA receptor system by positron emission tomography, a NR2B selective NMDA receptor antagonist has been labelled with carbon‐11 (half‐life: 20 min). N ‐[4‐(4‐fluorobenzyl)piperidin‐1‐yl]‐ N ′‐(2‐oxo‐1,3‐dihydrobenzimidazol‐5‐yl)oxamide has been described demonstrating high affinity and selectivity for the NR2B receptors (IC 50 of 5 nM in [ 3 H]Ro‐25,6981 binding assay). The labelling precursor and the reference compound were synthesized by coupling ...
Tópico(s): Pharmacological Receptor Mechanisms and Effects
2009 - Wiley | Journal of Labelled Compounds and Radiopharmaceuticals
Fabrice G. Siméon, Franck Sobrio, Fabienne Gourand, Louisa Barré,
A rapid route for the synthesis of radiolabelled t-PAstop8, an efficient serine protease inhibitor, is described. (E,E)-2,7-Bis(4-iodobenzylidene)cycloheptan-1-one 2a was obtained in high yields (>90%) from cycloheptanone and 4-iodobenzaldehyde, with the unprecedented use of CsOH or by microwave irradiation using catalytic amounts (<20%) of bis(methoxyphenyl) telluroxide (BMPTO). These methods are general and have been successfully applied to the high yielding preparation of other aldol adducts such as ...
Tópico(s): Carbohydrate Chemistry and Synthesis
2001 - Royal Society of Chemistry | Journal of the Chemical Society Perkin Transactions 1
Anwen M. Krause‐Heuer, Nicholas Howell, Lidia Matesic, Geetanjali Dhand, Emma Young, Leena Burgess, Cathy D. Jiang, Nigel A. Lengkeek, Christopher J. R. Fookes, Tien Pham, Franck Sobrio, Ivan Greguric, Benjamin H. Fraser,
Thirteen compounds in a new class of fluorinated 5-pyrrolidinylsulfonyl isatin derivatives were synthesised that have potent and selective inhibitory activity against effector caspases-3 and -7. With in vivo animal PET imaging studies of cerebral ischemia being planned, N-benzylation with selected para-substituted benzylic halides allowed systematic variation of lipophilicity (logP 1.94–3.31) without decreasing inhibition potency (IC50). From this series the p-methoxybenzyl analogue was selected for ...
Tópico(s): Metal complexes synthesis and properties
2012 - Royal Society of Chemistry | MedChemComm
Corien Oostendorp, Sarah Meyer, Monia Sobrio, Joyce van Arendonk, Ernst Reichmann, Willeke F. Daamen, Toin H. Van Kuppevelt,
Treatment of full-thickness skin defects with split-thickness skin grafts is generally associated with contraction and scar formation and cellular skin substitutes have been developed to improve skin regeneration. The evaluation of cultured skin substitutes is generally based on qualitative parameters focusing on histology. In this study we focused on quantitative evaluation to provide a template for comparison of human bio-engineered skin substitutes between clinical and/or research centers, and ...
Tópico(s): Microbial metabolism and enzyme function
2016 - Elsevier BV | Burns
Marie Médoc, Martine Dhilly, Lidia Matesic, Jérôme Toutain, Anwen M. Krause‐Heuer, J Delamare, Benjamin H. Fraser, O Touzani, Louisa Barré, Ivan Greguric, Franck Sobrio,
Tópico(s): ATP Synthase and ATPases Research
2015 - Springer Science+Business Media | Molecular Imaging and Biology
Franck Sobrio, Mostafa Amokhtari, Fabienne Gourand, Martine Dhilly, François Dauphin, Louisa Barré,
Tópico(s): Radiopharmaceutical Chemistry and Applications
2000 - Elsevier BV | Bioorganic & Medicinal Chemistry