Lucía Serrano Díaz del Campo, Ana B. García‐Redondo, Cristina Rodrı́guez, Carlos Zaragoza, Santiago Duro‐Sánchez, Francesco Palmas, Ángela de Benito-Bueno, Paula G. Socuéllamos, Diego A. Peraza, Raquel Rodrigues‐Díez, Carmen Valenzuela, Jesmond Dalli, Mercedes Salaíces, Ana M. Briones,
Resolution of inflammation is orchestrated by specialized proresolving lipid mediators (SPMs), and this would be impaired in some cardiovascular diseases. Among SPMs, resolvins (Rv) have beneficial effects in cardiovascular pathologies, but little is known about their effect on cardiovascular damage in hypertension.Aorta, small mesenteric arteries, heart, and peritoneal macrophages were taken from C57BL/6J mice, infused or not with angiotensin II (AngII; 1.44 mg/kg/day, 14 days) in presence or absence ...
Tópico(s): Adipose Tissue and Metabolism
2022 - Lippincott Williams & Wilkins | Hypertension
B. Aja, S. Arguedas Cuendis, Iván Arregui, E. Artal, R. B. Barreiro, F. J. Casas, Marina C. de Ory, Alejandro Díaz‐Morcillo, Luisa de la Fuente, J. D. Gallego, J. M. García-Barceló, B. Gimeno, A. Gómez, Daniel Granados, Bradley J. Kavanagh, Miguel A. G. Laso, T. Lopetegi, Antonio José Lozano Guerrero, María Teresa Magaz, J. Martín‐Pintado, E. Martínez-González, Jordi Miralda‐Escudé, Juan Monzó‐Cabrera, Francisco Najarro de la Parra, Jose R. Navarro-Madrid, Ana B. Nuñez Chico, Juan Pablo Pascual Gutiérrez, J. Pelegrín, C. Peña‐Garay, David Rodríguez, Juan M. Socuéllamos, Fernando Teberio, Jorge Teniente, P. Vielva, I. Vila, R. Vilar Cortabitarte, Enrique Villa,
We propose a novel experiment, the Canfranc Axion Detection Experiment (CADEx), to probe dark matter axions with masses in the range 330-460 $\mu$eV, within the W-band (80-110 GHz), an unexplored parameter space in the well-motivated dark matter window of Quantum ChromoDynamics (QCD) axions. The experimental design consists of a microwave resonant cavity haloscope in a high static magnetic field coupled to a highly sensitive detecting system based on Kinetic Inductance Detectors via optimized quasi-optics ( ...
Tópico(s): Cosmology and Gravitation Theories
2022 - Institute of Physics | Journal of Cosmology and Astroparticle Physics
... Sánchez S, Palmas F, de Benito-Bueno A, Socuéllamos P, Peraza D, Rodrigues-Díez R, Valenzuela C, ...
Tópico(s): Sodium Intake and Health
2014 - Lippincott Williams & Wilkins | Hypertension
María Fontillón, Alfredo J. Lucendo,
... of Gastroenterology, Hospital General de Tomelloso, Vereda de Socuéllamos, s/n, 13700 Tomelloso. Spain. E-mail: [email ...
Tópico(s): Eosinophilic Disorders and Syndromes
2012 - Lippincott Williams & Wilkins | The American Journal of Gastroenterology
Siham Lanjeri, D. Segarra, Joaquín Meliá,
... Mancha region: Mota del Cuervo, Las Mesas, Tomelloso, Socuellamos and Villarrobledo, with a surface area of 174 ...
Tópico(s): Horticultural and Viticultural Research
2004 - Taylor & Francis | International Journal of Remote Sensing
José M. Fraile, José I. Garcı́a, Clara I. Herrerı́as, José A. Mayoral, Oliver Reiser, Antonio Socuéllamos, Heiko Werner,
Abstract As shown by theoretical calculations, azabis(oxazoline)–copper complexes are considerably more stable than the analogous bis(oxazoline)–copper complexes. This enhanced stability allows them to be efficiently immobilized by means of electrostatic interactions to different anionic supports, such as clays and nafion–silica nanocomposites, without the loss of a ligand, as is observed for bis(oxazolines). As a result, enantioselectivities of around 90 % ee are obtained in the cyclopropanation ...
Tópico(s): Synthetic Organic Chemistry Methods
2004 - Wiley | Chemistry - A European Journal
Juan M. Socuéllamos, Roberto Dionisio, Rosa Letizia, Claudio Paoloni,
Meander lines are promising slow-wave structures (SWSs) for millimeter-wave traveling-wave tubes (TWTs) due to low-cost manufacture, low-voltage operation, and high interaction impedance. However, experimental results on meander lines are rare in the literature. Phase velocity and interaction impedance are the most important parameters for the design and characterization of TWT SWSs. Their experimental determination in meander lines is crucial for validating simulations and developing new topologies. ...
Tópico(s): Microwave Engineering and Waveguides
2021 - IEEE Microwave Theory and Techniques Society | IEEE Transactions on Microwave Theory and Techniques
Pilar Cercós, Diego A. Peraza, Ángela de Benito-Bueno, Paula G. Socuéllamos, Abdoul Aziz-Nignan, Dariel Arrechaga-Estévez, Escarle Beato, Emilio Peña-Acevedo, Armando Albert, Juan A. González‐Vera, Yoel Rodrı́guez, Mercedes Martín‐Martínez, Carmen Valenzuela, Marta Gutiérrez‐Rodríguez,
Ion channels are macromolecular complexes present in the plasma membrane and intracellular organelles of cells. Dysfunction of ion channels results in a group of disorders named channelopathies, which represent an extraordinary challenge for study and treatment. In this review, we will focus on voltage-gated potassium channels (KV), specifically on the KV4-family. The activation of these channels generates outward currents operating at subthreshold membrane potentials as recorded from myocardial ...
Tópico(s): Receptor Mechanisms and Signaling
2021 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Diego A. Peraza, Pilar Cercós, Pablo Miaja, Yaiza G. Merinero, Laura Lagartera, Paula G. Socuéllamos, Carolina Izquierdo García, Sara A. Sánchez, Alejandro López-Hurtado, Mercedes Martín‐Martínez, Luis Alcides Olivos-Oré, José R. Naranjo, Antonio R. Artalejo, Marta Gutiérrez‐Rodríguez, Carmen Valenzuela,
Downstream Regulatory Element Antagonist Modulator (DREAM)/KChIP3/calsenilin is a neuronal calcium sensor (NCS) with multiple functions, including the regulation of A-type outward potassium currents (IA). This effect is mediated by the interaction between DREAM and KV4 potassium channels and it has been shown that small molecules that bind to DREAM modify channel function. A-type outward potassium current (IA) is responsible of the fast repolarization of neuron action potentials and frequency of firing. ...
Tópico(s): Neuroscience and Neuropharmacology Research
2019 - Frontiers Media | Frontiers in Molecular Neuroscience
... of Gastroenterology, Hospital General de Tomelloso, Vereda de Socuellamos, s/n, 13700 Tomelloso, Ciudad Real, Spain e- ...
Tópico(s): Pancreatic and Hepatic Oncology Research
2013 - Springer Science+Business Media | Digestive Diseases and Sciences
Juan M. Socuéllamos, Raquel Rodriguez Monje, Ken B. Cooper, Matthew Lebsock, Srinivas Prasad Mysore Nagaraja, José V. Siles, Robert M. Beauchamp, Simone Tanelli,
The development of radar systems operating at G-band (110 - 300 GHz) with small size, weight, and power requirements can offer new possibilities for probing clouds and precipitation from space and lead to novel mission concepts. To advance the technology needed to achieve such objective, a ground-based G-band Doppler radar prototype for atmospheric profiling has been developed and demonstrated with different targets. This article describes the radar architecture and discusses the instrument calibration ...
Tópico(s): Soil Moisture and Remote Sensing
2024 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Geoscience and Remote Sensing
Jesús Galán-Vidal, Paula G. Socuéllamos, María Baena-Nuevo, Lizbeth Contreras, Teresa González, María Pérez-Poyato, Carmen Valenzuela, Domingo González‐Lamuño, Alberto Gandarillas,
Abstract Background Novel developmental mutations associated with disease are a continuous challenge in medicine. Clinical consequences caused by these mutations include neuron and cognitive alterations that can lead to epilepsy or autism spectrum disorders. Often, it is difficult to identify the physiological defects and the appropriate treatments. Results We have isolated and cultured primary cells from the skin of a patient with combined epilepsy and autism syndrome. A mutation in the potassium ...
Tópico(s): Bipolar Disorder and Treatment
2022 - BioMed Central | Orphanet Journal of Rare Diseases
David Banon-Caballero, Juan M. Socuéllamos, R. Mata, Laura Mercadé, B. Gimeno, Vicente E. Boria, David Raboso, V. E. Semenov, E. Rakova, Juan F. Sánchez‐Royo, A. Segura,
Secondary electron emission has an important role on the triggering of the multipactor effect; therefore, its study and characterization are essential in radio-frequency waveguide applications. In this paper, we propose a theoretical model, based on equivalent circuit models, to properly understand charging and discharging processes that occur in dielectric samples under electron irradiation for secondary electron emission characterization. Experimental results obtained for Pt, Si, GaS, and Teflon ...
Tópico(s): Electrostatic Discharge in Electronics
2018 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Plasma Science
Juan M. Socuéllamos, Raquel Rodriguez Monje, Matthew Lebsock, Ken B. Cooper, Robert M. Beauchamp, Arturo Umeyama,
... at https://doi.org/10.5281/zenodo.10076227 (Socuellamos et al., 2024).
Tópico(s): Meteorological Phenomena and Simulations
2024 - Copernicus Publications | Earth system science data
Paula G. Socuéllamos, Luis Alcides Olivos-Oré, María Victoria Barahona, Pilar Cercós, Marta Pérez Pascual, Marina Arribas-Blázquez, José R. Naranjo, Carmen Valenzuela, Marta Gutiérrez‐Rodríguez, Antonio R. Artalejo,
Neuropathic pain is a form of chronic pain arising from damage of the neural cells that sense, transmit or process sensory information. Given its growing prevalence and common refractoriness to conventional analgesics, the development of new drugs with pain relief effects constitutes a prominent clinical need. In this respect, drugs that reduce activity of sensory neurons by modulating ion channels hold the promise to become effective analgesics. Here, we evaluated the mechanical antinociceptive ...
Tópico(s): Ion channel regulation and function
2022 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Ángela de Benito-Bueno, Paula G. Socuéllamos, Yaiza G. Merinero, Pilar Cercós, Carolina Izquierdo García, Miguel Daniel-Mozo, Irene Marín-Olivero, Ángel Pérez-Lara, Juan A. González‐Vera, Ángel Orte, Armando Albert, Mercedes Martín‐Martínez, Marta Gutiérrez‐Rodríguez, Carmen Valenzuela,
The transient outward potassium current (Itof) is generated by the activation of KV4 channels assembled with KChIP2 and other accessory subunits (DPP6 and KCNE2). To test the hypothesis that these subunits modify the channel pharmacology, we analyzed the electrophysiological effects of (3-(2-(3-phenoxyphenyl)acetamido)-2-naphthoic acid) (IQM-266), a new KChIP2 ligand, on the currents generated by KV4.3/KChIP2, KV4.3/KChIP2/DPP6 and KV4.3/KChIP2/KCNE2 channels. CHO cells were transiently transfected ...
Tópico(s): Nicotinic Acetylcholine Receptors Study
2022 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Arthur S. Aiton, Gustavo Avalos Guzman,
Tópico(s): Historical Studies on Spain
1943 - Duke University Press | Hispanic American Historical Review
Tópico(s): Latin American history and culture
1943 - Duke University Press | Hispanic American Historical Review
Clara Serrano‐Novillo, Irene Estadella, María Navarro‐Pérez, Anna Oliveras, Ángela de Benito-Bueno, Paula G. Socuéllamos, Manel Bosch, María José Coronado, Daniel Sastre, Carmen Valenzuela, Christian Soeller, Antônio Felipe,
Abstract Aim The voltage‐gated Kv7.1 channel, in association with the regulatory subunit KCNE1, contributes to the I Ks current in the heart. However, both proteins travel to the plasma membrane using different routes. While KCNE1 follows a classical Golgi‐mediated anterograde pathway, Kv7.1 is located in endoplasmic reticulum‐plasma membrane junctions (ER‐PMjs), where it associates with KCNE1 before being delivered to the plasma membrane. Methods To characterize the channel routing to these spots ...
Tópico(s): Neuroscience and Neural Engineering
2024 - Wiley | Acta Physiologica
Alicia de la Cruz, Carlotta Ronchi, Chiara Bartolucci, Paula G. Socuéllamos, Ángela de Benito-Bueno, Stefano Severi, Antonio Zaza, Carmen Valenzuela,
Tópico(s): Neuroscience and Neuropharmacology Research
2025 - Elsevier BV | Biomedicine & Pharmacotherapy
Chantal Biencinto, Mercedes García García, Elvira Carpintero Molina, Patricia Villamor Manero, Miriam García-Socuéllamos,
Partiendo de la propuesta recogida en el conocido Informe Delors que caracteriza los cuatro pilares de la educación, el artículo plantea el diseño de la Rúbrica de Competencias Docentes PROFICIENCyIn+E® de autoevaluación para docentes en ejercicio de primaria y secundaria. El objetivo de este artículo es presentar la validación de la rúbrica con población de docentes mexicanos. La muestra participante es de 3515 docentes de 172 centros educativos de enseñanzas no universitarias de México. Utilizando ...
Tópico(s): Higher Education Teaching and Evaluation
2025 - Organization of Ibero-American States | Revista Iberoamericana de Educación
Paula G. Socuéllamos, Francisco M. Cruz, Álvaro Macías, Alba Vera‐Zambrano, Juan Manuel Ruiz Robles, Ana Isabel Moreno Manuel, Gema Mondéjar‐Parreño, Carmen Prior, Teresa González, Antonio J. Cartón, Carmen Valenzuela, José Jalife,
Tópico(s): Endoplasmic Reticulum Stress and Disease
2025 - Elsevier BV | Heart Rhythm
Magalí Colomer-Molera, Daniel Sastre, Ángela de Benito-Bueno, Paula G. Socuéllamos, Carmen Valenzuela, Antônio Felipe,
Tópico(s): Cardiac electrophysiology and arrhythmias
2025 - Elsevier BV | Biophysical Journal
Juan Manuel Ruiz Robles, Isabel Carrascoso, Francisco M. Cruz, Álvaro Macías, Ana Isabel Moreno Manuel, Patricia Sánchez-Pérez, Paula G. Socuéllamos, Francisco José Bermúdez-Jiménez, Gema Mondéjar‐Parreño, Lilian K. Gutiérrez, A Gutiérrez, Eva Cabrera Borrego, Fernando Martínez, Juan Jiménez‐Jáimez, José Jalife,
Tópico(s): Mitochondrial Function and Pathology
2025 - Elsevier BV | Heart Rhythm
Daniel Sastre, Magalí Colomer-Molera, Sara R. Roig, Ángela de Benito-Bueno, Paula G. Socuéllamos, Gregorio Fernández‐Ballester, Carmen Valenzuela, Antônio Felipe,
The voltage-gated potassium channel Kv1.3 plays a crucial role in the immune system response. In leukocytes, the channel is co-expressed with the dominant negative regulatory subunit KCNE4, which associates with Kv1.3 to trigger intracellular retention and accelerate C-type inactivation of the channel. Previous research has demonstrated that the main association between these proteins occurs through both COOH-termini. However, these data fail to fully elucidate the KCNE4-dependent modulation of ...
Tópico(s): Viral Infections and Immunology Research
2024 - American Physical Society | AJP Cell Physiology
Juan M. Socuéllamos, Raquel Rodriguez Monje, Matthew Lebsock, Ken B. Cooper, Pavlos Kollias,
Abstract. The profile of the liquid water content (LWC) in clouds provides fundamental information for understanding the internal structure of clouds, their radiative effects, propensity to precipitate, and degree of entrainment and mixing with the surrounding environment. In principle, differential absorption techniques based on coincident dual-frequency radar reflectivity observations have the potential to provide the LWC profile. Previous differential frequency radar reflectivity (DFR) efforts ...
Tópico(s): Precipitation Measurement and Analysis
2024 - Copernicus Publications | Atmospheric measurement techniques
Paula G. Socuéllamos, Ángela de Benito-Bueno, Maria Ropero, Sara Diez, Pablo Elizalde, M. Angeles Bonache, Carmen Viedma, Mercedes Martín‐Martínez, Marta Gutiérrez‐Rodríguez, Carmen Valenzuela,
Kv4 channels generate rapidly activating and inactivating outward currents responsible for the repolarization of both cardiac and neuronal action potentials through ITO (transient outward current) and IA (A-type K+ current), respectively. Kv4 dysfunctions have been identified in both cardiac and neuronal diseases (Brugada syndrome, atrial fibrillation, epilepsy or Alzheimer's disease). However, Kv4 channels need to assemble with regulatory subunits to fully reproduce ITO and IA currents. Among them, ...
Tópico(s): Mass Spectrometry Techniques and Applications
2023 - Elsevier BV | Biophysical Journal
Marina Arribas-Blázquez, María Victoria Barahona Gomariz, Fernando González Gómez, Paula García Socuéllamos, Sergio Gascón Jiménez, Mariano Diaz-Flores Ramos, Rocío Ruiz Domínguez, Luis Alcides Olivos-Oré,
M. Arribas-Blázquez1M.V. Barahona Gomariz1F. González Gómez1P. García Socuéllamos1S. Gascón Jiménez1M. Diaz-Flores Ramos1R. Ruiz Domínguez2L.A. Olivos-Oré1
Tópico(s): Educational Innovations and Technology
2019 - International Academy of Technology, Education and Development | INTED proceedings