Arthur Leathley, Transport Correspondent, Martin Fletcher and Peter Riddell, Jon Ashworth, Noreen Taylor, Joanna Hunter, Nick Nuttall Environment Correspondent, Robert Cole, Business Editor Patience Wheatcroft, Patricia Davies, Zahid Hussain, Adrian Lee, Grace Bradberry, Nick Makin, Simon Barnes, Jasper Rees, Frances Gibb and Roland Watson, G. Pocock, Christopher Walker, Chief Ireland Correspondent, Raymond Snoddy, Media Editor, Jane Bolton, Philip Howard, Hilary Finch, Caroline Merrell, Banking Correspondent, James Bone, Roland Watson and Paul Durman, David Robinson and Perry Cleveland-Peck, Christine Buckley Industrial Correspondent, Robert Sheehan, Bridge Correspondent, Joe Joseph, David McVay, Richard Duce and Russell Jenkins, Donald Hutera, Stewart Tendler Crime Correspondent, Martin Stephen, Dominic Walsh, George Thomas, Alasdair Reid, Raymond Keene Chess Correspondent, Robin P. Cole, Michael Harvey, Melvin J. Lasky Editor, David Orr and Michael Evans, Richard Ford Home Correspondent, Alan Hamilton, Mark Inglefield, Andre Menache Prisident, John O'Leary, Ian Hughes, Keith Pike, W. D. O'brien, David Hands, Charles Bremner, John Kavanagh, Jane Napolitano, Catherine Lockwood, Peter Barnard, Michael Binyon Diplomatic Editor, Derwent May, Jilly Cooper, Paula Hawkins, Paul Armstrong, Richard Cork, John Bercow, Paul Durman, Ken Livingstone, H. McG. Dunnett, John Hopkins, Karen Homer, Laurence McTaggart, Rob Wright, Stephen Wood, Dalya Alberge, Arts Correspondent, Adam Jones, Marcus Binney, Raymond Keene, Clive Mathieson, John Russell Taylor, Matt Dickinson, Tom Baldwin, Deputy Political Editor, Paul Wilkinson, David Orr, Nigel Hawkes, Ashley Grossman, Carl Mortished, International Business Editor, Tony Patrick and Louise Godfrey, Gavin Lumsden, Insurance Correspondent, Roger Boyes, Nick Hasell, Philip Webster, Political Editor, Robert Cole, City Correspondent, Oliver Holt, Football Correspondent, David Hands Rugby Correspondent, Anne Ashworth, Giles Whittell, Saeed Shah, Mel Webb, Kevin McCarra, Anjana Ahuja, Kyran Bracken, George Caulkin, Melissa Kite Political Reporter, Aubrey Bristow, Victoria Greenhalgh, Peter Gaupp, Ben MacIntyre, Roy Hattersley, Jeremy Hart, Michael Dynes, David Sinclair, Simon Jenkins, Simon Mathews, Tim Jones, Lea Paterson, Mark Henderson, Martin Waller, Chris Ayres, Alan Coren, Mark Baldwin, Daniel Rosenthal, Alan Copps Interface Editor, Benedict Nightingale, Richard Morrison, Alyson Rudd, Sam Kiley, Alice Miles, Arthur Leathley, Valerie Grove, Harriet Harman, Tom Baldwin Deputy Political Editor, Michael Evans, Alan Lee Racing Correspondent, Sally Patten, Anthony Howard, David L. Crosby, Chairman, Christopher Irvine, Susan Emmett,
... of Scotland JUG club beats FTSE Vodafone The 'sonic hedgehog' gene that could cure baldness Scientists have managed ...
1999 - Gale Group | TDA
Laura A. Genovesi, Amanda Millar, Elissa Tolson, Matthew Singleton, Emily Hassall, Marija Kojic, Caterina Brighi, Emily J. Girard, Clara Andradas, Mani Kuchibhotla, Dharmesh D. Bhuva, Raelene Endersby, Nicholas G. Gottardo, Anne Bernard, Christelle Adolphe, James M. Olson, Michael D. Taylor, Melissa J. Davis, Brandon J. Wainwright,
... mice bearing patient-derived xenograft tumours of the Sonic Hedgehog and Group 3 subtype, providing the first demonstration of its efficacy in MB. Conclusions ...
Tópico(s): Protein Degradation and Inhibitors
2021 - BioMed Central | Genome Medicine
Tijuca Rio de Janeiro, Taki, Tara Palmer-Tomkinson's, Waldemar Januszczak, John Dugdale, Michael Prescott, Victoria McKee, Christopher Middleton, Barney Spender, Barbara Hall, Aa Gill, Royal Ballet, Donald MacGillivray, Michelene Wandor, Ellie Giles, Lewis Reed, John Peter, Emma Moore, Surf bikinis, Anthony Edwards, Alicia Wyllie Deputy Money Editor, Lesley White, John Jay, Christopher Somerville, Phillip Taylor, Emine Saner, Monica Crowley, Ivo Tennant, Abbey, Ferdinand Mount, Addison de Witt, S C Peterborough, Dr C Cole, Allan Brown, Lars Persson, David Smith, Ed Wallis's, David Eden, Edin Hamzic, Sally Payne, Chris Dignan, Nick Pitt, Donu Kogbara, Neil Wormald, E Warmington, Andrew Sullivan, Ruport stolner, Clive Davis, Vincent Kearney, Carol Sarler, Mary Wilson, Karen Robinson, K R, Dr Roger Henderson, Ivo Pogorelich, Andrew Grice Political Editor, Thrasy Petropolous, Peter Wardley, Tony Allen-Mills, Simon Wilde, Martin James, Robert Sandall, Eleanor Mills, Anthony Sattin, Steve Farrar, Andrew Nebel Director of Marketing, Robert Hewison, Peter Wilson, Roger Anderson, Angela Mollard, Philip Flaxton, Lucas Black, Norman Davies, Ann Widdecombe, Darcey Bussell, Philip Kingsley, L P, Damon Hill, Bill Hagerty, Sarah Toyne, David Hewson, Harvey Porlock, Yvonne Ridley, Margaret Coles, Hugh Canning, David Caims, Jeremy Clarkson, Peter Kemp, Edward Porter, Stewart Lee, John Waples Deputy City Editor, Michael Jones, Ms L B Peterborough, George Perry, Robin Marlar, Graham Otway, Hugh McManners Defence Correspondent, Nick Gardner, Shelley von Strunckel, Cl-P, A Francis, Naomi Campbell, Paul Ham, Stuart Wavell, Maggie Gee, Paul Donovan, William Shawcross, Veronica Masters, Sue Lawrence, Justin Cartwright, Sandra Kasalo, Stan Labovitch, Paul Driver, Derek Clements, L G, Peter Windsor, Ian Hawkey, Ian Chadband, Alex Ferguson, Christopher Morgan, Alicia Wyllie, Dr Tom Parry, John Ashelford Director, Michael Prescott Chief Political Correspondent, Tom Shone, Mark Edwards, Sarah Gracie, Susan Clark, Fiona McHugh, Mark Austin, Jack Epstein, Hugh McLlvanney, Nicholas Rufford Home Affairs Editor, Malcolm Gloak, Edward Crabtree, Phil Baker, Michael Riding, John Harlow Arts Correspondent, Hugo Barnacle, Lois Rogers, Bob Graham, Raymond Keene, John Karter, Stanley Stewart, Cosmo Landesman, Peter Davison, Andrew Roberts, Andrew Butcher, Tony Fernandes, Debbie Hill, Diana Wright, Andrew Ritchie, M Carmichael, Simon Willis, Nicholas Tucker, Chris Partridge, Stephen Jones, Richard Evans, Nick Cain, Fiery Donald, M Lowe, Natalie Graham, Andrew Smith, Paul Nuki, David Pleat, Pere Ubu, Amenda Ursell, Keith Wheatley, Claire Oldfield, David Walsh, Caroline Gascoigne, John Stern, Trevor Lewis, Jack Grimston, Ruport Steiner, Barry Simms, Rasselas, S F G, Stephen Armstrong, Christopher Goodwin, John Carlos, Paul Kavanagh, Josh Salzmann, R W Johnson, Sheryl Garratt, Diana, Roland White, Miss Jean Brodie, Dr John Hemming, Chatterley, Ruport Stolner, Rachel Cooke, John Travolta, Maurice Chittenden, Kevin Pratt, Andrew Lorenz Business Editor, Kevin Donovan, Judith O'Reilly, Ray Hutton, John Wilcockson, Jon Ungoed-Thomas, Andrew Rogers, Peter Watts, Susan Elkin, George Orwell, Michael Sheridan, Redgrave Crew, Sean Hargrave, Fay Weldon, David Starkey, John Harlow, Christine Webb, Matthew Lynn, Godfrey Smith, Ted Hughes, Ian Thomson, Bob Davis, Nia Williams, Mary Chalaye, J A, Andrew Alderson, John Waples, Gareth Jenkins, Roy Hattersley, A A Gill, Jeremy Hart, Andrew Stephen, Matthew Campbell, Lloyd Webber, John Carey, David Hutcheon, Rajeev Syal, Neil Hamilton, Nadine Meisner, Robert Johnston, Jim Clark, Stephen Pettitt, Trushar Barot, Cherry Norton, Robert Prior, Andrew Lorenz, Liam Clarke, David Wickers, Emily Jewsbury, Mark Hodson, Mary Henderson, Ray Perry, Rupert Steiner, Ali Stewart, Chris Lightbown, Lucy Broadbent, Hugh Pearman, Dave Selby, David Parsley, John Phillips, John Burns, David Smith Economics Editor, J R, Simon Trump, Zoe Linkson, Richard Nixon, Jonathan Aitken, Frank Taylor, Carey Scott, Stephen Boyd, Joanna Simon, Simon Howard, Dan Pearson, Dominic Rushe, Boris Schapiro, Adam Parsons,
... battle flag Saab Cambridge honours its forgotten women Sonic hedgehog alarm keeps death off roads Teletubby creator to ...
1998 - Gale Group | Sunday Times HA GDA
K Sakurada, Mikiko Ohshima-Sakurada, Theo D. Palmer, Fred H. Gage,
... dopaminergic determination, including FGF receptors 1, 2 and 3, the sonic hedgehog receptor components Smo and Ptc, and the region- ...
Tópico(s): Photochromic and Fluorescence Chemistry
1999 - The Company of Biologists | Development
Susan D'arcy, Michael Prescott, Julia Pascal, Barbara Hall, Annie Chaplin, Toby Young, Tony Birtley, Paul Nelson, Richard Ellis, Seosamh O Murchú, John Davison, Peter Frank, Helen Davidson, Debbie Moore, diana Wright, John Peter, Mark Reason, John Harlow Transport Correspondent, Jonathan Miller, Eric Dymock, Norman MacRae, Lesley White, Dr Mary Henry, Bill Gates, Tony Francis, Susan d'Arcy, John Akers, John Diamond, Graham Rose, Diana Wright Personal Finance Editor, Alistair Scott, Sally Payne, David Smith, Nicholas Hinton Director-general, Adam Nicolson, Nick Pitt, Taylor, Frederic Raphael, Charles Hymas, Edward Welsh, Richard Guilliatt, Caroline Lees Arts Correspondent, Tony Allen-Mills, Martin James, Robert Sandall, Joanne Harris, Benedic Hayhoe, Ivan Allen Exhibition Director, Iain Johnstone, Nilgin Yusuf, Irwin Stelzer, Ivan Fallon, Deryk Brown, Isabel Wolff, David Dougill, Cliff Temple, Ally McCoist, Ingrid Millar, Harvey Porlock, Hugh Canning, Margarette Driscoll, Peter Kemp, Sean Ryan, Geoff Whitten, Peter Millar, Caroline Lees, Ismail Merchant, Peter Kellner, Richard Dawood, George Perry, John Cassidy, Kristle Hamilton, Mark Skipworth, Anatole Kaletsky, Nick Gardner, Lynne Routledge, Stewart Roberts, Jonathan Margolis, Christine Toomey, Richard Lloyd Parry, Bernard Cafferty, David Bowie, Stuart Wavell, Roger Eglin, Paul Donovan, Paul Eastman, Christopher Llyod, Jeff Randall, Shelley von Strunkel, James Bethell, R Nicholson-Morton, James Adams, Paul Driver, Margaret Dibben, Charlie Bubbles, Nicholas Fraser, Tim Rayment, Peter Plant, Kirstie Hamilton, Rufus Olins, David Lawrenson, Brian Sewell, Martin Jacques, Nicola Lang, Dave Thomas, Christopher Lloyd, Derek Hudson, Helen Fielding, kristie Hamilton, Lois Rogers, Margaret Campbell, John Karter, Jack Aspinall, Malcolm Winton, Peter Hall, Greg Hadfield, Diana Wright, Craig Brown, Stephen Jones, Imogen Edwards-Jones, Andrew Grice Chief Political Correspondent, Quentin Crisp, Andrew Grice, Irwin Steizer, Julie Cohen, Keith Wheatley, Annie Murphy, Ian Birrell, Anthony Quinn, Marcel Berlins, Safa Haeri, Lois Rogers Medical Correspondent, Chris Jones, Andrew Hogg, Bruce Johnston, R Scheer, T Rac Smith, Richard Woods, Garth Alexander, Paul Kennedy, Peter Johnson, David Churchill, Alan Dershowitz, Maurice Chittenden, Sarah-Rhiannon Barber, N E Gayle, Dr Richard Sakwa, David Oates, Kristie Hamilton, Dai Jeffries, Julie Burchill, David, Michael Jones Political Editor, Roger Clarke, Rebecca Fowler, Nicholas Archer, David Hunn, John Bowman, Berry Tomalin Head of Marketing, D J Taylor, Mihir Bose, John Harlow, Matthew Lynn, Michael Austin, Hugh Fearnley-Whittingstall, Andrew Alderson, Alastair Burnet, Matthew Campbell, Stan Levenson, John Carey, Brian Innes, Christopher Summerfield, Chrissy Iley, Robert Leyshon, Lauren St John, Tom Tickell, Gilbert Adair, John Furbisher, Liam Clarke, David Wickers, Alan Ruddock, Goliath, Victor Bryant, Chris Lightbown, Mia Farrow, Nigel Roebuck, Jeff Randall City Editor, Hugh Pearman, David Smith Economics Editor, Penny Perrick, Tony Hetherington, Walter Ellis, Joanna Simon, kirstie Hamilton, Iain Jenkins, Janine di Giovanni, Boris Schapiro,
... sales by their former hero, asks Alan Ruddock Sonic the Hedgehog Stogecoach Holdings plc Swansea Centre for Trade & Industry Mario and Sonic fight the PC pirates Top computer-game makers ...
1993 - Gale Group | Sunday Times HA GDA
Jeffrey S. Dome, A. Thomas Look,
... activation of telomerase, 2) dysregulation of the patched/sonic hedgehog pathway, and 3) mutation of the INK4 alpha-ARF locus.
Tópico(s): Epigenetics and DNA Methylation
1999 - Lippincott Williams & Wilkins | Current Opinion in Oncology
Andrew Robson, Ian Raath, Michael Dynes and Daniel McGrory, Raymond Snoddy Media Editor, Andrew Pierce, James Moore, Patricia Davies, Grace Bradberry, Nicholas Serota, Director, Sarah Potter, Simon Barnes, Paul Hoggart, Claire McDonald, Richard Hobson, Martin Richards, David Rhys Jones, Ivo Tennant, Jonathan Lennie, Michael Evans Defence Editor, Philip Howard, Anders Panum Jensen Secretary General, Alexandra Frean Social Affairs Correspondent, Elizabeth Judge, Lynne Truss, Ernest Spacey, Morag Preston, Barbara Hewson, Kevin Eason, Geoff Brown, Joe Joseph, Andrew Norfolk, John O'Leary Education Editor, Laura Campbell, Conal Urquhart, David McVay, Pat Gibson, Tom O'Sullivan, Paul Baskerville (President), Gary Jacob, Hugh Leggatt, Alix Ramsay Tennis Correspondent, Kevin Eason Motor Racing Correspondent, Dalya Alberge Arts Correspondent, Edward Bridger-Stille, Michael Mulvihill, Mark Inglefield, Bernard Connolly, Mike Rosewell Rowing Correspondent, Stephen Farrell, John O'Leary, Helen Rumbelow Medical Reporter, Frances Lowe, David Hands, Charles Bremner, Kate Kirwan, Peter Barnard, Roger Maynard and Tim Reid, James Doran City Correspondent, Daniel McGrory, Paul Armstrong, Aileen Moss, Julian K-C Ma, Paul McCann, Bernard J. Mulholland, Lisa Armstrong, Tom Baldwin, Matt Dickinson Football Correspondent, Anna Söderblom, David Lawrenson, Christopher Martin-Jenkins, John Hopkins Golf Correspondent, Geoffrey Dean, Alec McGivan, Celia Brayfield, Stuart Miles, David Powell Athletics Correspondent, Raymond Keene, Adam Sage, David Robinson, Clive Mathieson, Sue Unwin, Matt Dickinson, Alix Ramsay, Christine Buckley Industrial Editor, Peter Bryan, Tony Swann, Chris Ayres Media Business Correspondent, Richard Owen, Roger Bootle Economic, Christopher Martin-Jenkins Chief Cricket Correspondent, Mick Hume, Barry Oakley, Roger Boyes, Anne Ashcroft, David Hands Rugby Correspondent, Julian Muscat, Ben Hammersley, John Allison, William Rees-Mogg, John Goodbody, Nick Szczepanik, James Doran, Alan Copps, Krishna Sethia, Mel Webb, Michael Fitzpatrick, Srikumar Sen Boxing Correspondent, Kevin McCarra, Graham Searjeant Financial Editor, Sean Hargrave, George Caulkin, Chris McGrath, Sam Westmacott, Tim Wapshott, Moira Petty, Caitlin Moran, Michael Austin, Alan Lee, Keith Blackmore, Adam Sage and Andrew Norfolk, Ben MacIntyre, Peter Riddell, Tony Dawe, Michael Dynes, Deryke Belshaw, Lea Paterson, Fran Littlewood, Roy Jenkins, Lindsay Nicolle, Tom Baldwin Deputy Political Editor, Robert Whymant, Sally Patten, Lea Paterson Economics Correspondent, David Wright, Fraser Nelson Retail Correspondent, Don Paterson and Jo Shapcott, Dr Keyboard, Christopher Irvine, Joanna Coles, John Watson, Arthur Leathley Transport Correspondent,
... Tournament puts new slant on TV game show Sonic the Hedgehog's on the phone for you My kind ...
2000 - Gale Group | TDA
Robert M. Gemmill, James West, Ferenc Boldog, Naotake Tanaka, Linda Robinson, Jeremy C. Smith, Frederick W. B. Li, Harry A. Drabkin,
... extracellular loop that participates in the binding of sonic hedgehog. In the 3;8 translocation, TRC8 is fused to FHIT and ...
Tópico(s): Genetics and Neurodevelopmental Disorders
1998 - National Academy of Sciences | Proceedings of the National Academy of Sciences
George Cole, Stephen Woodard, Director, Anthony Harris, Jon Ashworth, Nick Nuttall, Andrew Pierce, Chris Ward, Grace Bradberry, Robin Dartington, Director, Richard Ford, Home Correspondent, Bill Frost, George Ball, Andrew Longmore, Catherine Field, Harvey Elliott, Philip Howard, Dorothy Sullivan, Jeremy Kingston, Rachel Campbell-Johnston, Sheila Johnston, Agence France-Presse and Christopher Thomas, Carl Mortished, Morag Preston, Gillian Maxey, Kevin Eason, James Bone and our Foreign Staff, Robert Sheehan, Bridge Correspondent, Robert Miller, Kate Alderson and Joanna Bale, Guy Clapperton, Raymond Keene Chess Correspondent, Rachel Kelly, Audrey Magee Ireland Correspondent, Harry Brampton, Charles Bremner and Michael Hornsby, Mike Rosewell Rowing Correspondent, Rodney Milnes, Jenny MacArthur, Francesco Bongarra, Michael Clark, Jeremy Laurance, Health Correspondent, Quentin Letts, Sam Kiley, Africa Correspondent, and James Bone, Joseph Connolly, John Kavanagh, Jill Sherman and Andrew Pierce, Philip Bassett, Industrial Editor, G. M. Covey, Luke Clancy, Ian Murray Community Correspondent, Brenda Maddox, Leyla Linton and our Foreign Staff, Belinda Archer, John Hopkins, David Miller, Alan Toogood, Horticulture Correspondent, Dalya Alberge, Arts Correspondent, Michael Prestage, Michael Hornsby, Agriculture Correspondent, and Diana Thorp, Hubert Chesshyre, Raymond Keene, Christine Buckley, Valerie Howarth, Chief Executive, Emma Wilkins and Simon De Bruxelles, Alix Ramsay, P. H. S, Chris Partridge, James Morgan, Eric Reguly, John Carr, Sarah Cunningham, Malcolm Windsor, Secretary, Nick Kelly, Denis O'brien, Dalya Alberge, Alison Beckett, Julian Muscat, Adam Fresco, Jill Sherman and Philip Webster, Christopher Thomas, John Goodbody, Dominic Kennedy, Iola Smith, Nick Nuttall, Technology Correspondent, Sara McConnell, Christopher Walker, James Pringle, Chris Parker, Brian MacArthur, Jason Nissé, Craig Lord, Anjana Ahuja, Michael Hornsby, Peter Riddell, Ben MacIntyre, Ray Hatley, Atlanta sketch, Ian Brodie, Alan Lee Cricket Correspondent, Tony Dawe, Frances Lass, David Sinclair, Simon Jenkins, Fraser Nelson, Tim Jones, Simon Armson, Chief Executive, Alan Coren, Christopher Warman, Benedict Nightingale, Nigel Powell, Tom Rhodes, Frances Gibb Legal Correspondent, Lindsay Nicolle, Michael Evans Defence Correspondent, Morag Prestion, Richard Morrison, Gordon Brown, Branson claims, David Maddock, Alice Thomson, Political Reporter, Alasdair Murray, Collin Cowe, George Racz, Nicholas Temperley, Matthew Bond, Tunku Varadarajan and our Foreign Staff, Amandip Upal, Edward Gorman Sailing Correspondent, Richard Ford, Kevin Eason, Motoring Editor, Olympic diary, Stacy Sullivan, George Guise, Stephen Cox Campaigns manager,
... on a system that gives extra spikes to Sonic the Hedgehog Full control of an emergency A US system ...
1996 - Gale Group | TDA
Guopei Luo, Jiang Long, Xiaobo Cui, Zhiwen Xiao, Zuqiang Liu, Si Shi, Liang Liu, Chen Liu, Jin Xu, Min Li, Xianjun Yu,
... was significantly inhibited by gemcitabine combined with the sonic hedgehog inhibitor cyclopamine. The BxPC-3-LN cells expressed lower levels of let-7, ...
Tópico(s): Mesenchymal stem cell research
2013 - Spandidos Publishing | International Journal of Oncology
Richard Harries, Chairman, Arthur Leathley, Transport Correspondent, R. Kristiansen, Ken Hughes, Nick Nuttall Environment Correspondent, Robert Cole, Michael Aylwin, Catherine Riley, Andrew Pierce, Olu Abiola, Chairman, Stephen Farrell and Arthur Leathley, Transport Correspondent, Rob Hughes, Simon Barnes, Alison ELLIOTCovernor, Julian Lee, Paul Hoggart, Claire McDonald, Bernard Kaukas, Frances Gibb, Legal Editor, Reports from the Bar Conference, Michael Evans Defence Editor, Philip Howard, Hilary Finch, Steve Branley, Norman De Mesquita, Mark Benham and Adam Sherwin, Uri Geller, Michael Paterson, Carla Quirighetti, James Landale, Political Correspondent, Michael Evans, Defence Editor, Eduard Fuller, David Robinson and Perry Cleveland-Peck, Tony Patrick, Stewart Tendler, Crime Correspondent, Jorge Elias, Tim Rodber, Fraser Nelson, Retail Correspondent, Robert Sheehan, Bridge Correspondent, Ernest A. Hounsell, Mark Benham, Pat Gibson, David McVay, Ruth Gledhill, Religion Correspondent, Nick Martin, Donald Hutera, Ruth Gledhill, Shirley English, John O'leary, Education Editor, Alasdair Reid, Michael Forrest, Raymond Keene Chess Correspondent, Keith Dugdale, Ross Dunn, Audrey Magee Ireland Correspondent, Rita Carter, Alan Hamilton, Robin Young, Mark Inglefield, Rodney Milnes, Alice Lagnado, Frederick Hutchinson, Tony Blair, James Landale Political Correspondent, Helen Rumbelow Medical Reporter, Ian Hughes, Keith Pike, Alix Ramsay, Tennis Correspondent, David Hands, Jean Glavany, Mark Giles, Gerald CORBETTChief Exeutive, Rodney Mlines, Lisa Armstrong Fashion Editor, Peter Barnard, Michael Howard, Christopher Pinsent, Paula Hawkins, Russell Kempson, Paul Durman, David Lister, Nicholas Harling, John Hopkins, Arthur Leathley and Clive Mathieson, Rob Wright, Stephen Wood, David Watts, Stuart Miles, Adam Jones, Raymond Keene, Adam Sage, Clive Mathieson, Matthew Pryor, Richardson of Calow Moderator, Matt Dickinson, Alison Kervin Rugby Editor, David Coffey, General Secretary, Oliver Holt, Richard Owen, Damian Whitworth, Jeremy Fletcher, Mick Hume, Roger Boyes, Nigel Hawkes, Science Editor, Martin Woods, Paul Fitzapatrick, Nick Hasell, Sydney Friskin and Cathy Harris, Oliver Holt, Football Correspondent, Christopher Massey, David Hands Rugby Correspondent, Roger Bootle, Jennifer O'Neill, Nick Szczepanik, John Goodbody, Simon Munk, Alan Copps, Alex O'Connell, Mel Webb, Witold Gutt, Kevin McCarra, Jennai Cox, Sean Hargrave, George Caulkin, Chris McGrath, Tim Wapshott, Walter Gammie, Peter Riddell, Oliver Chastney, Ray Hatley, Ian Brodie, Edward Karam, Tony Dawe, Michael Dynes, Fraser Nelson, Lea Paterson, Mark Henderson, Chris Ayres, Mark Baldwin, Roger Rowberry, Benedict Nightingale, Peter Smith Chairman, Nigel Powell, John B. Sheldon, Stephen Dalton, Bill Edgar, Valerie Grove, Adam Sherwin, Alex O'connell, Carl Mortished and David Lister, Richard Ford, John Bennett, Christopher Irvine, Christine Buckley, Industrial Correspondent,
... on ice are cute—but not so entertaining Sonic's bright new world Saga's hedgehog hits a new level, says Tim Wapshott Top ...
1999 - Gale Group | TDA
... of the brain-derived neurotrophic factor, neurotrophin-3, sonic hedgehog, nerve growth factor, Six-3 and the Lh-2 group of genes in the transcriptional level after experimentally induced myopia (form-deprivation by goggles and by hyperopic defocus using negative spectacle lenses) were evaluated by semiquantitative reverse transcriptional polymerase chain reaction and Northern blot analysis.Results showed that only the sonic hedgehog gene was differentially expressed in the experimentally induced ...
Tópico(s): Intraocular Surgery and Lenses
2001 - Springer Science+Business Media | Japanese Journal of Ophthalmology
Srikumar Sen, Boxing Correspondent, Michael Clark, Stock Market Correspondent, James Landale, Julia Llewellyn Smith, Anne Tully, Member, Tom Hewitt, Peter Middleton, Joanna Clark, Gillian Rowe, Geoffrey N. Silman, Srikumar Sen, boxing correspondent, Gerald Vinestock, Simon Barnes, Richard Ford, Home Correspondent, Tim Judah, Alexandra Frean, Media Correspondent, Stuart Freedman, John Diamond, Giles Gordon, Angela MacKay, Philip Howard, Drag queen, John Marriott, John Walters, James Bone, I. A. Shapiro, Nigel S. Cobb, Nicola Cole, Lynne Truss, Albert Dormer, David Flusfeder, Eve-Ann Prentice, Diplomatic Correspondent, Philip Bassett Industrial Editor, Joe Joseph, Robert Miller, Francesca Greenoak, David Rowland, Ruth Gledhill, Religion Correspondent, Steve May, Robin Hunt, John Hopkins, Golf Correspondent, Peter Ball, Ruth Gledhill, Graham Duffill, Nicholas Watt, Ireland Correspondent, Raymond Keene Chess Correspondent, Louise Taylor, Rob Hughes Football Correspondent, Jane MacQuitty's, Peter Waymark, Alan Hamilton, Robin Young, Robert Mitchell, Chairman, Jenny MacArthur, Michael Clark, Eve-Ann Prentice, Richard Scott, Dominic Mills, Anne Mcelvoy, Doug Sager, George Sivell Assistant Business Editor, Keith Pike, R. D. O'driscoll, Peter Davies, David Hands, Laurie Taylor, Charles Bremner, Russell Hewitson, Zoe Young, Margaret Fairburn, Jeremy Bennett, Sarah Bagnall, Christine Stone, Peter Barnard, Ramnick Shah, Derwent May, Anthony Lester, Sally Jones, Jessica Gorst-Williams, Geraldine Harrison, Sydney Friskin, Chad Varah, Nicholas Harling, David Miller, Richard Ford and Kevin Eason, Mark Almond, Ronald Riggs, Raymond Keene, Geoffrey Clarke, David Robinson, Peter Davalle, Leanne Benjamin, Emma Wilkins, David Nursaw, Paul Wilkinson, Richard Evans, Nigel Hawkes, Alice Thomson, Maggie McGill, Shannon W. Brock, Joan Cowper, Barry Pickthall, Doug Seger, Roger Boyes, Stephanie Billen, Jessica Douglas-Home, Humphry Berkeley, David Hands Rugby Correspondent, Julian Muscat, Nicholas Wood, Chief Political Correspondent, Andrew Pierce and Arthur Leathley, John Goodbody, Dominic Kennedy, Jane Bidder, Giles Whittell, Sara McConnell, Sarah Bagnall Insurance Correspondent, James Pringle, Matthew Parris, Ivor Herbert, Sara McConnell and Robert Morgan, Godfrey Smith, Clarissa Hyman, Ben MacIntyre, Sarah Jane Checkland, Sarah Marsh, Richard Beeston, Angela Buxton, Alan Jenkins, Simon Jenkins, Philip Pangalos, Michael Horsnell, Hyam MacCoby, Christian de Lisle, Christopher Elliott, Benedict Nightingale, Derwent May's, Tom Rhodes, Michael Hornsby Countryside Correspondent, Richard Morrison, Bea Cowan, Michael Henderson, Anne McElvoy, Lindsay Cook Deputy Business Editor, R. Wright, Fiona Beckett, George W. Keeling, P. Glaister, Matthew Bond, Vivian Russell's, Ronald F. Yule, Christian Dymond, Hilary Kingsley, Barry Hyman, Frances Bissell's, Edward Marriott, Melvyn Marckus,
... to First World War designs Deafened by the Sonic boom In the luerative Christmas market for video games, a small blue hedgehog is still the king Nikon Festive events Sales ...
1993 - Gale Group | TDA
Lone Kroeldrup, Søren K. Kjærgaard, Maria Kirchhoff, K. Kock, Charlotte Brasch‐Andersen, Maria Kibæk, Lilian Bomme Ousager,
Tópico(s): Congenital limb and hand anomalies
2012 - Elsevier BV | European Journal of Medical Genetics
Anna Marie Kenney, Hans R. Widlund, David H. Rowitch,
... cells in the developing cerebellum require activity of the sonic hedgehog (Shh) and phosphoinositide-3-kinase (PI3K) pathways for growth and survival. Synergy between the Shh and PI3K signaling pathways are implicated in ...
Tópico(s): Glioma Diagnosis and Treatment
2003 - The Company of Biologists | Development
Paul Gibson, Yiai Tong, Giles Robinson, Margaret C. Thompson, D. Spencer Currle, Christopher Eden, Tanya A. Kranenburg, Twala L. Hogg, Helen Poppleton, Julie M. Martin, David Finkelstein, Stanley Pounds, Aaron Weiss, Zoltán Patay, Matthew Scoggins, Robert J. Ogg, Yanxin Pei, Zeng-jie Yang, Sonja N. Brun, Youngsoo Lee, Frédérique Zindy, Janet C. Lindsey, Makoto M. Taketo, Frederick A. Boop, Robert A. Sanford, Amar Gajjar, Steven C. Clifford, Martine F. Roussel, Peter J. McKinnon, David H. Gutmann, David W. Ellison, Robert J. Wechsler‐Reya, Richard J. Gilbertson,
... neuron precursor cells (GNPCs) after aberrant activation of the Sonic Hedgehog pathway (hereafter, SHH subtype)3,4,5,6,7,8. The pathological processes that drive heterogeneity among the other ...
Tópico(s): Teratomas and Epidermoid Cysts
2010 - Nature Portfolio | Nature
Nicholas G. Gottardo, Jordan R. Hansford, Jacqueline P. McGlade, Frank Alvaro, David M. Ashley, Simon Bailey, David L. Baker, Franck Bourdeaut, Yoon-Jae Cho, Moira A. Clay, Steven C. Clifford, Richard J. Cohn, Catherine Cole, Peter B. Dallas, Peter Downie, François Doz, David W. Ellison, Raelene Endersby, Paul G. Fisher, Tim Hassall, John A. Heath, Hilary Hii, David Jones, Reimar Junckerstorff, Stewart J. Kellie, Marcel Kool, Rishi S. Kotecha, Peter Lichter, Stephen Laughton, Sharon Lee, Geoffrey McCowage, Paul A. Northcott, James M. Olson, Roger J. Packer, Stefan M. Pfister, Torsten Pietsch, Barry Pizer, Scott L. Pomeroy, Marc Remke, Giles Robinson, Stefan Rutkowski, Tobias Schoep, Anang A. Shelat, Clinton F. Stewart, Michael Sullivan, Michael D. Taylor, Brandon J. Wainwright, Thomas Walwyn, William A. Weiss, Dan Williamson, Amar Gajjar,
... at least four distinct molecular subgroups: WNT/Wingless, Sonic Hedgehog, Group 3, and Group 4. The Medulloblastoma Down Under 2013 meeting, which convened at ...
Tópico(s): Chromatin Remodeling and Cancer
2013 - Springer Science+Business Media | Acta Neuropathologica
Cristina Luongo, Raffaele Ambrosio, Salvatore Salzano, Andrzej A. Dlugosz, Caterina Missero, Monica Dentice,
... TH metabolism mediated by the iodothyronine deiodinases. Type 3 deiodinase (D3) inactivates T3 via specific deiodination reactions. It is an oncofetal protein frequently expressed in neoplastic tissues and is a direct target of the sonic hedgehog (Shh) pathway in basal cell carcinomas (BCCs). However, ...
Tópico(s): Cancer and Skin Lesions
2014 - Oxford University Press | Endocrinology
... and investigated the underlying mechanisms by focusing on the sonic hedgehog (Shh) and phosphoinositide 3-kinase (PI3K) pathways. Three kinds of colon cancer cells and BALB/c nude mice were used to evaluate the antiproliferative effect of EGCG. The apoptosis, migration, and ...
Tópico(s): Advanced Breast Cancer Therapies
2021 - NRC Research Press | Canadian Journal of Physiology and Pharmacology
Laura A. Lettice, Sarah Daniels, Elizabeth Sweeney, Shanmugasundaram Venkataraman, Paul S. Devenney, Philippe Gautier, Harris Morrison, Judy Fantes, Robert E. Hill, David Fitzpatrick,
... synpolydactyly. The HPES plausibly results from the 7q36.3 breakpoint dislocating the sonic hedgehog (SHH) gene from enhancers that are known to drive expression in the early forebrain. However, the limb phenotype cannot be explained by loss of known SHH enhancers. The SHH transcription unit is relocated to 7q22.1, ∼190 kb 3' of a highly conserved noncoding element (HCNE2) within ...
Tópico(s): Genomic variations and chromosomal abnormalities
2011 - Wiley | Human Mutation
Vijay Ramaswamy, Michael D. Taylor,
... the four molecular subgroups of medulloblastoma-wingless (WNT), sonic hedgehog (SHH), group 3, and group 4-in the daily treatment of patients, as well in the ...
Tópico(s): Chromatin Remodeling and Cancer
2017 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
Gianmarco Pallavicini, Giorgia Iegiani, Gaia Berto, Elisa Calamia, Edoardo Trevisiol, Andrea Veltri, Simona Allis, Ferdinando Di Cunto,
... it is classified into four biological subgroups: WNT, Sonic Hedgehog (SHH), Group 3 and Group 4. The current treatment is surgery, followed by irradiation and chemotherapy. Unfortunately, these therapies are only partially ...
Tópico(s): Epigenetics and DNA Methylation
2020 - Multidisciplinary Digital Publishing Institute | Cancers
Zhenghua Liu, Ni Yin, Lianghui Gong, Zhiping Tan, Bangliang Yin, Yifeng Yang, Cheng Luo,
... of TPT‑PS has been mapped to 7q36.3. Sonic hedgehog (SHH) expressed in the zone of polarizing activity (ZPA) has an important ...
Tópico(s):
2016 - Spandidos Publishing | Molecular Medicine Reports
Maria Łastowska, Joanna Trubicka, Magdalena Niemira, Magdalena Paczkowska‐Abdulsalam, Agnieszka Karkucińska‐Więckowska, Magdalena Kaleta, Monika Drogosiewicz, Marta Perek‐Polnik, Adam Krętowski, Božena Cukrowská, Wiesława Grajkowska, Bożenna Dembowska–Bagińska, Ewa Matyja,
... of at least four molecular types: Wingless (WNT), Sonic Hedgehog (SHH), Group 3 and Group 4 tumors. The latter two groups, which can be identified by ...
Tópico(s): Renal and related cancers
2018 - Springer Science+Business Media | Journal of Neuro-Oncology
Francia Fang, Jared S. Rosenblum, Winson S. Ho, John D. Heiss,
... molecular subtype. The four consensus subgroups are WNT, Sonic hedgehog (SHH), Group 3, and Group 4, which underpin the current 2021 WHO classification of MB. While the ...
Tópico(s):
2022 - Multidisciplinary Digital Publishing Institute | Cancers
Christine L. White, W. Samantha N. Jayasekara, Daniel Picard, Jasmine Chen, D. Neil Watkins, Jason E. Cain, Marc Remke, Daniel J. Gough,
... transcription factor Signal Transducer and Activator of Transcription 3 (STAT3) in the Sonic Hedgehog (SHH) medulloblastoma subgroup. Specific deletion of Stat3 from ...
Tópico(s): Chromatin Remodeling and Cancer
2019 - Multidisciplinary Digital Publishing Institute | Cancers
Alla Maloverjan, Marko Piirsoo, Lagle Kasak, Lauri Peil, Torben Østerlund, Priit Kogerman,
The Sonic hedgehog (Shh) signaling pathway controls a variety of developmental processes and is implicated in tissue homeostasis maintenance and neurogenesis in adults. Recently, we identified Ulk3 as an active kinase able to positively regulate Gli proteins, mediators of the Shh signaling in mammals. Here, we provide several lines of evidence that Ulk3 participates in the transduction of the Shh signal also independently of its kinase activity. We demonstrate that Ulk3 through its kinase domain ...
Tópico(s): Epigenetics and DNA Methylation
2010 - Elsevier BV | Journal of Biological Chemistry
Sandrine Faure, Pascal de Santa Barbara,
... caudally in the midgut and hindgut endoderm, respectively (3,4). Sonic Hedgehog (Shh), a member of the Hedgehog (Hh) family of morphogens, is expressed in the entire endodermal layer but not in the pancreas (3). Moreover, Litingtung et al (5) reported a specific ...
Tópico(s): Digestive system and related health
2011 - Lippincott Williams & Wilkins | Journal of Pediatric Gastroenterology and Nutrition
Giles Robinson, Vasilisa A. Rudneva, Ivo Buchhalter, Catherine A. Billups, Sebastian M. Waszak, Kyle Smith, Daniel C. Bowers, Anne Bendel, Paul G. Fisher, Sonia Partap, John R. Crawford, Tim Hassall, Daniel J. Indelicato, Frederick A. Boop, Paul Klimo, Noah D. Sabin, Zoltán Patay, Thomas E. Merchant, Clinton F. Stewart, Brent A. Orr, Jan O. Korbel, David Jones, Tanvi Sharma, Peter Lichter, Marcel Kool, Andrey Korshunov, Stefan M. Pfister, Richard J. Gilbertson, Robert P. Sanders, Arzu Onar‐Thomas, David W. Ellison, Amar Gajjar, Paul A. Northcott,
... 1% (95% CI 34·6–67·6) in the sonic hedgehog (SHH) subgroup (n=42), 8·3% (95% CI 0·0–24·0%) in the group 3 subgroup (n=24), and 13·3% ( ...
Tópico(s): Neuroblastoma Research and Treatments
2018 - Elsevier BV | The Lancet Oncology
Feng-Chi Chang, Tai‐Tong Wong, Kuo-Sheng Wu, Chia‐Feng Lu, Ting-Wei Weng, Muh‐Lii Liang, Chih‐Chun Wu, Wan Yuo Guo, Cheng‐Yu Chen, Kevin Li‐Chun Hsieh,
... is divided into four distinct groups: wingless (WNT), sonic hedgehog (SHH), Group 3, and Group 4. We analyzed the magnetic resonance imaging radiomics features to find the ...
Tópico(s): Pancreatic and Hepatic Oncology Research
2021 - Public Library of Science | PLoS ONE