Project Gutenberg
David S. Hong, Yasutoshi Kuboki, John H. Strickler, Marwan Fakih, Hélène Houssiau, Timothy Price, Elena Élez, Salvatore Siena, Emily Chan, Jane Nolte-Hippenmeyer, Panli Cardona, Qui Tran, Toshiki Masuishi,
3513 Background: Soto, a KRAS G12C inhibitor, had a 9.7% objective response rate (ORR) as monotherapy for chemorefractory patients (pts) ... 30%, supporting the model that the doublet mitigates Soto-related feedback reactivation of the RAS-MAPK pathway and accumulation of activated EGFR. We hypothesize that Soto plus Pmab and FOLFIRI will further enhance Soto efficacy while maintaining a manageable safety profile. We ... from CodeBreaK 101 subprotocol H (NCT04185883) who received Soto (960 mg PO daily) plus Pmab (6 mg/ ...
Tópico(s): Lung Cancer Treatments and Mutations
2023 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
Project Gutenberg
Nicholas G. Norwitz, Michael R. Mindrum, Philippe Giral, Anatol Kontush, Adrian Soto‐Mota, Thomas R. Wood, Dominic P. D’Agostino, Venkat Sanjay Manubolu, Matthew J. Budoff, Ronald M. Krauss,
... very low-carbohydrate ketogenic diet1Norwitz NG Feldman D Soto-Mota A Kalayjian T DS L Elevated LDL- ... hyper-responder (LMHR) phenotype,1Norwitz NG Feldman D Soto-Mota A Kalayjian T DS L Elevated LDL- ... past several months, several publications1Norwitz NG Feldman D Soto-Mota A Kalayjian T DS L Elevated LDL- ... Nutr. 2021; : 1-10PubMed Google Scholar,3Norwitz NG Soto-Mota A Feldman D Parpos S M B ... 13830325Crossref PubMed Scopus (3) Google Scholar,4Norwitz NG Soto-Mota A Kaplan B Ludwig DS Budoff M ... a carbohydrate restricted diet.1Norwitz NG Feldman D Soto-Mota A Kalayjian T DS L Elevated LDL- ...
Tópico(s): Nutrition, Genetics, and Disease
2022 - Elsevier BV | Journal of clinical lipidology
Marwan Fakih, Gerald S. Falchook, David S. Hong, Rona Yaeger, Emily Chan, Omar Mather, Panli Cardona, Tian Dai, John H. Strickler,
Soto, a specific, irreversible KRASG12C inhibitor, has monotherapy clinical activity in KRAS p.G12C-mutated solid tumors, ... can lead to accumulation of activated EGFR. Combining Soto with an EGFR inhibitor may produce synergistic antitumor activity. The safety and efficacy of Soto with PMab, a monoclonal antibody specific to EGFR, ... identify a safe/tolerable daily oral dose of Soto with PMab (6mg/kg IV Q2W) in patients ( ... enrolled in dose exploration with 960 mg QD Soto and 6mg/kg IV Q2W PMab. Median number ...
Tópico(s): HER2/EGFR in Cancer Research
2021 - Elsevier BV | Annals of Oncology
Leticia San Martín‐Rodríguez, Nelia Soto‐Ruiz, Guillermo Echeverria‐Ganuza, Paula Escalada‐Hernández,
... Search for more papers by this authorMaria Nelia Soto-Ruiz, Corresponding Author Maria Nelia Soto-Ruiz nelia.soto@unavarra.es Correspondence: Maria Nelia Soto-Ruiz, Department of Health Sciences, Public University of ... 00 34 948 166 117; E-mail: nelia.soto@unavarra.esSearch for more papers by this authorGuillermo ... Search for more papers by this authorMaria Nelia Soto-Ruiz, Corresponding Author Maria Nelia Soto-Ruiz nelia.soto@unavarra.es Correspondence: Maria Nelia Soto-Ruiz, Department of Health Sciences, Public University of ...
Tópico(s): Augmented Reality Applications
2019 - Wiley | Medical Education
Jennifer L. Graham, Guy M. Foster, Thomas J. Williams, Matthew D. Mahoney, Madison R. May, Keith A. Loftin,
... data were collected at several sites (Wamego, De Soto, and three main reservoir-fed tributaries) on the ... chlorophyll, was consistently higher at the downstream De Soto site than the upstream Wamego site. Higher algal biomass at the De Soto site likely was caused by algal growth during ... processes. Algal biomass at the Wamego and De Soto sites was negatively correlated with streamflow and total ... cyanobacterial abundances typically were higher at the De Soto site than the Wamego site. Cyanobacterial abundances generally ...
Tópico(s): Soil and Water Nutrient Dynamics
2018 - United States Geological Survey | Scientific investigations report
... N, Davis B, Schaeberle CM, Sonnenschein C and Soto AM, 2013. Perinatally Administered Bisphenol A Acts as ... Gadbois JL, Tharp AP, Whitt GS, Sonnenschein C, Soto AM, 2011. Perinatal exposure to environmentally relevant levels ... Durando M, Kass L, Piva J, Sonnenschein C, Soto AM, Luque EH and Munoz-de-Toro M, ... Luque EH, de Toro MM, Sonnenschein C and Soto AM, 2001. In utero exposure to bisphenol a ... CM, Wadia PR, Rubin BS, Sonnenschein C and Soto AM, 2005. Long-term effects of fetal exposure ... PR, Luque EH, Rubin BS, Sonnenschein C and Soto AM, 2005. Perinatal exposure to bisphenol-A alters ...
Tópico(s): Pharmaceutical studies and practices
2015 - European Food Safety Authority | EFSA Supporting Publications
... et al., 2005Castilla J. Saá P. Hetz C. Soto C. In vitro generation of infectious scrapie prions. ... Saborio et al., 2001Saborio G.P. Permanne B. Soto C. Sensitive detection of pathological prion protein by ... et al., 2005Castilla J. Saá P. Hetz C. Soto C. In vitro generation of infectious scrapie prions. ... of the infectious folding of the prion protein (Soto, 2011Soto C. Prion hypothesis: the end of the ... disease, Parkinson's disease, and type 2 diabetes (Soto, 2003Soto C. Unfolding the role of protein misfolding ...
Tópico(s): RNA regulation and disease
2012 - Cell Press | Cell
William T. Gibson, Rebecca L. Hood, Shing H. Zhan, Dennis E. Bulman, Anthony P. Fejes, Richard A. Moore, Andrew J. Mungall, Patrice Eydoux, Riyana Babul‐Hirji, Jianghong An, Marco A. Marra, David Chitayat, Kym M. Boycott, David D. Weaver, Steven J.M. Jones,
... mutated or deleted in most patients with classic Sotos syndrome [MIM 117550].4Douglas J. Hanks S. Temple ... N. NSD1 mutations are the major cause of Sotos syndrome and occur in some cases of Weaver ... R. et al.Spectrum of NSD1 mutations in Sotos and Weaver syndromes.J. Med. Genet. 2003; 40: ... fuelled debate among clinical geneticists regarding whether the Sotos and Weaver syndromes represent variable expressivity of a ... prominent macrocephaly, and features distinguishing Weaver syndrome from Sotos syndrome are retrognathia with a prominent chin crease ( ...
Tópico(s): Renal and related cancers
2011 - Elsevier BV | The American Journal of Human Genetics
Jae-Il Kim, Ignazio Calì, Krystyna Surewicz, Qingzhong Kong, Gregory J. Raymond, Ryuichiro Atarashi, Brent Race, Liuting Qing, Pierluigi Gambetti, Byron Caughey, Witold K. Surewicz,
... amplification" (PMCA) (7Castilla J. Saá P. Hetz C. Soto C. Cell. 2005; 121: 195-206Abstract Full Text ... A. Mukherjee A. Gonzalez-Romero D. Morales R. Soto C. PLoS Pathog. 2009; 5: e1000421Crossref PubMed Scopus ( ... brain homogenates (7Castilla J. Saá P. Hetz C. Soto C. Cell. 2005; 121: 195-206Abstract Full Text ... A. Mukherjee A. Gonzalez-Romero D. Morales R. Soto C. PLoS Pathog. 2009; 5: e1000421Crossref PubMed Scopus ( ... the seed (7Castilla J. Saá P. Hetz C. Soto C. Cell. 2005; 121: 195-206Abstract Full Text ... 23Piro J.R. Harris B.T. Nishina K. Soto C. Morales R. Rees J.R. Supattapone S. ...
Tópico(s): Neurological diseases and metabolism
2010 - Elsevier BV | Journal of Biological Chemistry
Paula Saá, Joaquı́n Castilla, Claudio Soto,
... and efficient way (12Saborio G.P. Permanne B. Soto C. Nature. 2001; 411: 810-813Crossref PubMed Scopus ( ... from diverse species (12Saborio G.P. Permanne B. Soto C. Nature. 2001; 411: 810-813Crossref PubMed Scopus ( ... isolated prions (15Castilla J. Saá P. Hetz C. Soto C. Cell. 2005; 121: 195-206Abstract Full Text ... experimentally infected with scrapie (16Castilla J. Saa P. Soto C. Nat. Med. 2005; 11: 982-985Crossref PubMed ... described previously (15Castilla J. Saá P. Hetz C. Soto C. Cell. 2005; 121: 195-206Abstract Full Text ...
Tópico(s): Prion Diseases and Protein Misfolding
2006 - Elsevier BV | Journal of Biological Chemistry
Katrina Tatton‐Brown, Jenny Douglas, Kim Coleman, Geneviève Baujat, Trevor Cole, Soma Das, Denise Horn, Helen E. Hughes, I. Karen Temple, Francesca Faravelli, Darrel Waggoner, Seval Türkmen, Valérie Cormier‐Daire, Alexandre Irrthum, Nazneen Rahman,
... only in functional domains (P<2×10−16). Sotos syndrome was clinically diagnosed in 99% of NSD1- ... of patients who have been clinically diagnosed with Sotos syndrome have identifiable NSD1 abnormalities, of which 83% ... overgrowth is not obligatory for the diagnosis of Sotos syndrome. A broad spectrum of associated clinical features ... suggesting that the underlying NSD1 mutational mechanism in Sotos syndrome may influence reproductive fitness. We identified 266 ... only in functional domains (P<2×10−16). Sotos syndrome was clinically diagnosed in 99% of NSD1- ...
Tópico(s): Congenital heart defects research
2005 - Elsevier BV | The American Journal of Human Genetics
... the property of their deceased master, Pedro de Soto López (former accountant and alguacil mayor of the ... petition was joined by that of Clara de Soto, wife of Francisco Camargo, acting "por mi derecho" ( ... minor children Juan Pedro, Thomás, and Joseph de Soto. Another petition was presented on behalf of Sebastián de Soto, also a minor. All claimed to have been ... ordered that captain Phelipe de Nabarijo— Pedro de Soto López's executor and holder of his goods— ... debts. The plaintiffs answered that since Pedro de Soto López was a familiar of the Inquisition, serving ...
Tópico(s): American Constitutional Law and Politics
2005 - Duke University Press | Hispanic American Historical Review
Sotos syndrome is an overgrowth syndrome characterised by pre- and postnatal overgrowth, macrocephaly, advanced bone age, and ... recently been reported as the major cause of Sotos syndrome while point mutations accounted for a minority ... patients with childhood overgrowth. The series included typical Sotos patients (23/39), Sotos-like patients (lacking one major criteria, 10/39), ... 6/33) and intragenic mutations (16/33) in Sotos syndrome patients. We also identified NSD1 intragenic mutations ... that NSD1 mutations account for most cases of Sotos syndrome and a significant number of Weaver syndrome ...
Tópico(s): Genomics and Rare Diseases
2003 - BMJ | Journal of Medical Genetics
Jenny Douglas, Sandra Hanks, I. Karen Temple, Sally Davies, Alexandra Murray, Meena Upadhyaya, Susan Tomkins, Helen E. Hughes, R.P. Trevor Cole, Nazneen Rahman,
Sotos syndrome is a childhood overgrowth syndrome characterized by a distinctive facial appearance, height and head circumference > ... NSD1, was reported as the major cause of Sotos syndrome, with intragenic NSD1 mutations identified in a ... in group 1 (n=37) was typical of Sotos syndrome; the phenotype in group 2 (n=13) was Sotos-like but with some atypical features; patients in ... 18) had an overgrowth condition that was neither Sotos nor Weaver syndrome. We detected three deletions and ... mutations of NSD1 are the major cause of Sotos syndrome and account for some Weaver syndrome cases ...
Tópico(s): Genetic factors in colorectal cancer
2003 - Elsevier BV | The American Journal of Human Genetics
Noriko Miyake, Naohiro Kurotaki, Hirobumi Sugawara, Osamu Shimokawa, Naoki Harada, Tatsuro Kondoh, Masato Tsukahara, Satoshi Ishikiriyama, Tohru Sonoda, Yoko Miyoshi, Satoru Sakazume, Yoshimitsu Fukushima, Hirofumi Ohashi, Toshiro Nagai, Hiroshi Kawame, Kenji Kurosawa, Mayumi Touyama, Takashi Shiihara, Nobuhiko Okamoto, Junji Nishimoto, Ko‐ichiro Yoshiura, Tohru Ohta, Tatsuya Kishino, Norio Niikawa, Naomichi Matsumoto,
Sotos syndrome (SoS) is characterized by pre- and postnatal overgrowth with advanced bone age; a dysmorphic face ... through a uniform mechanism but preferentially arose prezygotically. Sotos syndrome (SoS) is characterized by pre- and postnatal ... through a uniform mechanism but preferentially arose prezygotically. Sotos syndrome (SoS [MIM 117550]), cerebral gigantism, is an ... Niikawa N Matsumoto N Haploinsufficiency of NSD1 causes Sotos syndrome.Nat Genet. 2002; 30: 365-366Crossref PubMed ... N NSD1 mutations are the major cause of Sotos syndrome and occur in some cases of Weaver ...
Tópico(s): Wnt/β-catenin signaling in development and cancer
2003 - Elsevier BV | The American Journal of Human Genetics
Wen-Quan Zou, Neil R. Cashman,
... PubMed Scopus (792) Google Scholar, 4Saborio G.P. Soto C. Kascsak R.J. Levy E. Kascsak R. ... for nucleic acids (5Saborio G.P. Permanne B. Soto C. Nature. 2001; 411: 810-813Crossref PubMed Scopus ( ... PMCA of PrPSc (5Saborio G.P. Permanne B. Soto C. Nature. 2001; 411: 810-813Crossref PubMed Scopus ( ... Saborio et al.(5Saborio G.P. Permanne B. Soto C. Nature. 2001; 411: 810-813Crossref PubMed Scopus ( ... Saborio and colleagues (5Saborio G.P. Permanne B. Soto C. Nature. 2001; 411: 810-813Crossref PubMed Scopus ( ... brain PMCA system (5Saborio G.P. Permanne B. Soto C. Nature. 2001; 411: 810-813Crossref PubMed Scopus ( ...
Tópico(s): RNA regulation and disease
2002 - Elsevier BV | Journal of Biological Chemistry
Xue‐Ying He, Horst Schulz, Song‐Yu Yang,
... Alzheimer's disease (Yan, S. D., Fu, J., Soto, C., Chen, X., Zhu, H., Al-Mohanna, F., ... Alzheimer's disease (Yan, S. D., Fu, J., Soto, C., Chen, X., Zhu, H., Al-Mohanna, F., ... amyloid β-peptide (8Yan S.D. Fu J. Soto C. Chen X. Zhu H. Al-Mohanna F. ... a hydroxysteroid dehydrogenase (8Yan S.D. Fu J. Soto C. Chen X. Zhu H. Al-Mohanna F. ... Alzheimer's disease (8Yan S.D. Fu J. Soto C. Chen X. Zhu H. Al-Mohanna F. ... amyloid β-peptide (8Yan S.D. Fu J. Soto C. Chen X. Zhu H. Al-Mohanna F. ... ERAB peptide antibody (8Yan S.D. Fu J. Soto C. Chen X. Zhu H. Al-Mohanna F. ...
Tópico(s): Amino Acid Enzymes and Metabolism
1998 - Elsevier BV | Journal of Biological Chemistry
Rebecca Saunders, Lawrence A. Clayton, Vernon James Knight, Edward C. Moore,
... Luis Hernandez de Biedma, Factor of the De Soto Expedition, Newly Translated and Edited by John Worth, ... and Charles Hudson Account by Rodrigo Rangel, De Soto's Secretary, Newly Translated and Edited by John ... from The Report of 1935 United States De Soto Expedition Commission Various Short Documents from Buckingham Smith,Narratives of the Career of Hernando De Soto in the Conquest of Florida, New York 1866 El Adelantado Don Hernando De Soto, Rocio Sanchez Rubio Hernando De Soto, A Brief Biography, Paul H. Hoffman Some De ...
Tópico(s): Archaeology and Natural History
1995 - Southern Historical Association | The Journal of Southern History
... Scholar, 8Ganz PA Figlin RA Haskell CM La Soto N Siau J Supportive care versus supportive care ... metastases,8Ganz PA Figlin RA Haskell CM La Soto N Siau J Supportive care versus supportive care ... Scholar, 8Ganz PA Figlin RA Haskell CM La Soto N Siau J Supportive care versus supportive care ... Scholar,8Ganz PA Figlin RA Haskell CM La Soto N Siau J Supportive care versus supportive care ... Scholar, 8Ganz PA Figlin RA Haskell CM La Soto N Siau J Supportive care versus supportive care ... Scholar, 8Ganz PA Figlin RA Haskell CM La Soto N Siau J Supportive care versus supportive care ...
Tópico(s): Cancer Genomics and Diagnostics
1991 - Elsevier BV | CHEST Journal
Philip R. Dodge, Sandra J. Holmes, Juan F. Sotos,
... 63178Search for more papers by this authorJuan F. Sotos, Juan F. Sotos Department of Pediatrics, Ohio State University College of ... 63178Search for more papers by this authorJuan F. Sotos, Juan F. Sotos Department of Pediatrics, Ohio State University College of ... Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat REFERENCES 1 Sotos, J. F., Dodge, P. R., Muirhead, C., Crawford, ... CASPubMedWeb of Science®Google Scholar 3 Zonana, J., Sotos, J. F., Romshe, C. A., Fisher, D. A., ... Friis, B. (1976) 'Familial occurrence of cerebral gigantism, Sotos' syndrome. Acta Paediatrica Scandinavica, 65, 387–389. 10. ...
Tópico(s): Cleft Lip and Palate Research
1983 - Wiley | Developmental Medicine & Child Neurology
Daniel Arellanos-Soto, Verónica Bravo de la Cruz, N. Mendoza‐Tavera, Javier Ramos‐Jiménez, Rogelio Cázares-Tamez, Alicia Ortega-Soto, Ana María Rivas-Estilla,
... in an endemic area in Mexico D. Arellanos-Soto, D. Arellanos-Soto Universidad Autónoma de Nuevo León, Department of Biochemistry ... MexicoSearch for more papers by this authorA. Ortega-Soto, A. Ortega-Soto Blood Bank of the Transfusion Center of the ... for more papers by this author D. Arellanos-Soto, D. Arellanos-Soto Universidad Autónoma de Nuevo León, Department of Biochemistry ... MexicoSearch for more papers by this authorA. Ortega-Soto, A. Ortega-Soto Blood Bank of the Transfusion Center of the ...
Tópico(s): Malaria Research and Control
2015 - Wiley | Transfusion Medicine
A. Varvinski, FJ McGill, Victoria E. Judd, I. Hodzovic,
... to report the case of a child with Sotos' syndrome who presented for emergency orthopaedic surgery. This ... of this very rare syndrome, first described by Sotos in 1964. A 13-year-old girl, weighing ... have a full stomach. With regards to her Sotos' syndrome her mother reports two main problems: learning ... she showed some of the typical features of Sotos' syndrome including macrocephaly with a prominent forehead, dolichocephaly ... g. mitral valve prolapse, can also occur in Sotos' syndrome; however, our patient had a normal heart. ...
Tópico(s): Genomics and Rare Diseases
2001 - Wiley | Anaesthesia
Conrad Leitsmann, Annemarie Uhlig, Ionel Valentin Popeneciu, Margarete Boos, Sascha Ahyai, Marianne Schmid, Rolf Wachter, Lutz Trojan, Martin Friedrich,
... to evaluate the silent operation theatre optimisation system (SOTOS) in its effectiveness. In the operating room (OR) ... additional aspect of noise in the OR. The SOTOS surgical team used wired or wireless headphone/microphone ... stress level. We further captured subjective acceptance of SOTOS as well as perioperative data such as surgical ... two study arms. Sixteen surgeries were performed using SOTOS and 16 without (control). Overall, the mean sound pressure level in the SOTOS group was 3.6 dB lower compared to ...
Tópico(s): Intensive Care Unit Cognitive Disorders
2020 - Springer Science+Business Media | Journal of Robotic Surgery
Alison Foster, Anna Zachariou, Chey Loveday, Tazeen Ashraf, Edward Blair, Jill Clayton‐Smith, Huw Dorkins, Alan Fryer, Blanca Gener, David Goudie, Alex Henderson, Melita Irving, Shelagh Joss, Vaughan Keeley, Nayana Lahiri, Sally Ann Lynch, Sahar Mansour, Emma McCann, Jenny Morton, Nicole Motton, Alexandra Murray, Katie Riches, Deborah Shears, Zornitza Stark, Elizabeth Thompson, Julie Vogt, Michael Wright, Trevor Cole, Katrina Tatton‐Brown,
Abstract Sotos syndrome is an overgrowth‐intellectual disability (OGID) syndrome caused by NSD1 pathogenic variants and characterized by a ... and cardiac anomalies. However, many of the published Sotos syndrome clinical descriptions are based on studies of children; the phenotype in adults with Sotos syndrome is not yet well described. Given that ... since disruption of NSD1 was shown to cause Sotos syndrome, many of the children first reported are ... to investigate the phenotype of 44 adults with Sotos syndrome and NSD1 pathogenic variants. We have shown ...
Tópico(s): Congenital heart defects research
2019 - Wiley | American Journal of Medical Genetics Part C Seminars in Medical Genetics
Chloe Lane, Elizabeth Milne, Megan Freeth,
Sotos syndrome is a congenital overgrowth disorder, associated with intellectual disability. Previous research suggests that Sotos syndrome may be associated with relative strength in ... explicitly assessed. To date, the cognitive profile of Sotos syndrome is unknown. Cognitive abilities of a large and representative sample of individuals with Sotos syndrome (N = 52) were assessed using the British ... profile. Four specific criteria were proposed as the Sotos syndrome cognitive profile (SSCP): verbal ability > non-verbal ...
Tópico(s): Genetics and Neurodevelopmental Disorders
2018 - Wiley | Journal of Neuropsychology