Produção Nacional
Revisado por pares
Andressa Cardoso Raymundi, Bárbara Fernandes Menezes, Claudia Liliane Mendes Veloso, Julissandra Oliveira Cândido Vieira, Leticia Ferreira Sousa, Maria Eduarda Leal Rodrigues, Thaiz Alves Lopes Guimarães De Castro, Thays Borges Silva,
... reportada uma maior incidência nas raças Labrador Retriever, Springer Spaniel Inglês, Boxer, Doberman Pinscher, Pastor Australiano, Setter Irlandês e ...
Tópico(s): Cancer Diagnosis and Treatment
2023 - Faculdade Novo Milênio | Revista Foco
Primary persistent atrial standstill due to atrioventricular muscle dystrophy is a rare familial disease in dogs. The diagnosis of this disorder in a 5-month-old English springer spaniel is the earliest in dogs that have been presented at the Ontario Veterinary College.
Tópico(s): Cardiovascular Conditions and Treatments
2009 - Canadian Veterinary Medical Association | Canadian veterinary journal
Rudolph P. Johnson, A. D. J. Watson, Janine Smith, B. J. Cooper,
ABSTRACT At 6 weeks of age several Springer Spaniel littermates developed weakness which was exacerbated by exercise and alleviated by rest. Pharmacological testing and electromyographic studies indicated that the disorder resembled human myasthenia gravis. The initial response to neostigmine was satisfactory, but correct maintenance of dosage was difficult and two pups were electively destroyed. During 14 months of observation the third animal has shown continued requirement for treatment. Neostigmine ...
Tópico(s): Myasthenia Gravis and Thymoma
1975 - Wiley | Journal of Small Animal Practice
Urs Giger, Muredach P. Reilly, Toshio Asakura, Claudia J. Baldwin, John W. Harvey,
Summary Three families of English springer spaniel dogs with phosphofructokinase (PFK) deficiency causing haemolysis were studied. Four male dogs and one female dog with chronic haemolysis and haemolytic crises were found to have markedly reduced PFK activity in erythrocytes (8–20% of control English springer spaniels). PFK‐deficient erythrocytes exhibited an extreme alkaline and sucrose lysis. The oxygen dissociation curve of erythrocyte suspensions was shifted to the left with a 50% saturation of ...
Tópico(s): Metabolism and Genetic Disorders
1986 - Wiley | Animal Genetics
P.J. Healy, B. R. H. Farrow, F. W. Nicholas, Karen K. Hedberg, R. Murray Ratcliffe,
Plasma and leucocytes from six springer spaniels with clinical signs of fucosidosis had low activities of alpha-L-fucosidase. Fucosidase activities in plasma and leucocytes from parents of springers with fucosidosis were approximately half those in non-springer dogs. Examination of pedigree information in relation to classifications based upon plasma and leucocyte assays provided convincing evidence that fucosidosis is inherited in an autosomal recessive manner and that it is possible to detect ...
Tópico(s): Trypanosoma species research and implications
1984 - Elsevier BV | Research in Veterinary Science
Curtis W. Dewey, D.M. Boothe, K.L. Rinn, Joan R. Coates, William J. Burkholder,
Summary A ten‐year‐old, male castrated Springer Spaniel was presented for dysphagia, ptyalism, and regurgitation. Evidence of megaesophagus and mild aspiration pneumonia were apparent on thoracic radiographs. A diagnosis of focal acquired myasthenia gravis was suspected and subsequently confirmed with a positive serum acetylcholine (ACh) receptor antibody concentration (3.87 nM/L). A gastrostomy tube was placed shortly after presentation; food and drugs (including azathioprine) were administered through ...
Tópico(s): Peripheral Neuropathies and Disorders
2000 - Wiley | Journal of Veterinary Emergency and Critical Care
Sonja Fonfara, J. Loureiro, Simon Swift, R. James, Yolanda Martínez Pereira, J. López‐Alvarez, N. Summerfield, Joanna Dukes‐McEwan,
Objectives: English springer spaniels (ESS) are one of the most frequently presented breeds for pacemaker implantation in the UK and may do so at an early age. In comparison to dogs of other breeds (non-ESS) presenting for pacemaker implantation, cardiac troponin I (cTnI), the outcome and survival of ESS were investigated. Methods: Case records of dogs receiving pacemaker implantation were retrospectively reviewed. Results: Between September 2004 and October 2008, 58 dogs were presented to the Small ...
Tópico(s): Cardiac Valve Diseases and Treatments
2010 - Wiley | Journal of Small Animal Practice
Paul A. Cuddon, Chen‐Si Lin, Dwight D. Bowman, David S. Lindsay, Timothy K. Miller, Ian D. Duncan, A deLahunta, J. F. Cummings, Maja M. Suter, Barry Cooper, John M. King, J. P. Dubey,
Progressive paraparesis developed in four male English Springer Spaniel pups from a litter of five during the first 10 weeks of life. Two of the pups, which had the earliest onset of neurologic signs, were euthanatized without further workup. However, a detailed investigation was completed on the remaining two littermates at 12 weeks of age. Both pups had progressive paraparesis for 3 to 4 weeks before presentation, with one dog developing subsequent asymmetric pelvic limb extensor rigidity. Based ...
Tópico(s): Herpesvirus Infections and Treatments
1992 - Wiley | Journal of Veterinary Internal Medicine
David F. Edwards, John R. Kennedy, Clark S. Patton, Robert L. Toal, Gregory B. Daniel, Clinton D. Lothrop,
Abstract A laboratory‐maintained colony of English springer spaniel dogs heterozygous for a putative autosomal recessive immotile‐cilia syndrome (ICS) has been studied. Matings between dogs thought to be heterozygous for ICS resulted in 22 pups, five (three males and two females) of which were homozygous for ICS. Four of the five ICS‐affected dogs had chronic rhinitis and bronchopneumonia. The other dog had a serious nasal discharge and died at 10 days. Four dogs had situs inversus totalis (Kartagener ...
Tópico(s): Metabolism and Genetic Disorders
1989 - Wiley | American Journal of Medical Genetics
R. Bell, Carmel T. Mooney, Caroline Mansfield, B.R. Jones,
An eight‐year‐old, female springer spaniel was treated for metastatic insulinoma with a single intravenous dose of 500 mg/m2 streptozotocin (SZN), and pre‐and post‐treatment diuresis. A tapering dose of corticosteroids was also administered over a 28‐day period. SZN and corticosteroid administration resulted in resolution of hypoglycaemia and subsequent development of diabetes mellitus. Further metastases caused cervical spinal pain and the dog was euthanased 118 days after SZN administration. SZN ...
Tópico(s): Gestational Trophoblastic Disease Studies
2005 - Wiley | Journal of Small Animal Practice
A three‐year‐old, male springer spaniel had chronic left forelimb lameness with a medial glenohumeral ligament tear and articular cartilage damage diagnosed on arthroscopy. The animal failed to respond to conservative therapy of rest and an intra‐articular injection of methylprednisolone. The use of thermal capsulorrhaphy using bipolar radiofrequency bought about a return of joint stability and resolution of the lameness.
Tópico(s): Veterinary Equine Medical Research
2004 - Wiley | Journal of Small Animal Practice
ABSTRACT Hereditary cataract, due to a simple autosomal recessive gene, is described in the Welsh Springer Spaniel. A modified extracapsular cataract operation proved successful in restoring vision.
Tópico(s): Intraocular Surgery and Lenses
1980 - Wiley | Journal of Small Animal Practice
Jeanne M. Maddux, David F. Edwards, Mary Ann Barnhill, William Sanders,
In vitro neutrophil function was assessed in two English Springer Spaniel dogs, two Bichon Frise dogs, and one Chow Chow dog with congenital ciliary dyskinesia; three clinically normal English Springer Spaniel dogs that were presumed heterozygous for congenital ciliary dyskinesia; and five control dogs. Chemotaxis and random migration in affected and heterozygous dogs were found to be comparable to those of control dogs. Increased ( P ≤ 0.05) neutrophil adhesion, antibody dependent cell-mediated cytotoxicity, ...
Tópico(s): Epigenetics and DNA Methylation
1991 - SAGE Publishing | Veterinary Pathology
H.L. Swanson, R. R. Dubielzig, Ellison Bentley, Catherine J. Murphy,
An 8-week-old springer spaniel presented with a large central corneal opacity of the left globe, which was accompanied by cords of tissue spanning from the iris collarette to the posterior cornea. A posterior cortical cataract was noted in the right eye. At the owner's request the puppy was humanely destroyed, and a necropsy was performed. Upon sectioning the left globe in the vertical plane, a circle of pigmented strands of tissue was observed spanning the anterior chamber from the iris to the ...
Tópico(s): Corneal surgery and disorders
2001 - Elsevier BV | Journal of Comparative Pathology
James Elliott, Faye Swinbourne, A. T. Parry, Laura Baines,
A ten‐year‐old, female‐entire English springer spaniel presented with a large intra‐abdominal mass but no other clinical signs. Gastrointestinal stromal tumour of the caecum with widespread abdominal metastasis was confirmed. Treatment with toceranib phosphate resulted in complete response, despite the absence of exon‐8 or exon‐11 c‐kit mutation. There was no clinical evidence of tumour recurrence nine months after diagnosis.
Tópico(s): Oral and Maxillofacial Pathology
2017 - Wiley | Journal of Small Animal Practice
Dermot O’Toole, Stuart Young, G A Severin, S Neumann,
The histologic features of retinal dysplasia were studied in 26 English springer spaniel dogs of one day to four years of age. Dysplastic lesions in neonatal pups occurred predominantly in the peripapillary tapetal area of sensory retina. They consisted of complex linear folds and rosettes which were composed of hyperplastic neuroblasts. Dysplasia usually was not associated with incomplete differentiation of the outer neuroblastic layer. The outer limiting membrane was absent locally and numerous ...
Tópico(s): Connexins and lens biology
1983 - SAGE Publishing | Veterinary Pathology
Emily M. Pieczarka, Mamoru Yamaguchi, Maxey L. Wellman, M. Judith Radin,
Abstract A 13‐year‐old neutered male English Springer Spaniel was presented to The Ohio State University Veterinary Medical Center for evaluation of severe anemia. Upon blood smear review, approximately 50% of the platelets contained single to multiple variably sized clear vacuoles. Transmission electron microscopy of the platelets revealed hallmark features of autophagy, including membrane‐lined vesicles and vacuoles containing membrane whorls and degrading organelles. While autophagy has been ...
Tópico(s): Blood properties and coagulation
2014 - Wiley | Veterinary Clinical Pathology
A two‐year‐old, male English springer spaniel developed severe mucocutaneous ulceration following treatment with trimethoprim‐potentiated sulphadiazine. The clinical signs were consistent with Stevens‐Johnson syndrome (SJS): there were no target or arciform lesions typical of erythema multiforme minor and major; more than one mucosal surface was affected; epidermal detachment affected less than 10 per cent of the body surface area; and there was a clear history of drug exposure. Systemic signs included ...
Tópico(s): Oral and gingival health research
2004 - Wiley | Journal of Small Animal Practice
Mary O. Smith, David A. Wenger, Steven L. Hill, J. L. Matthews,
Fucosidosis was detected in a family of English Springer Spaniels in the United States. To our knowledge, these are the first reported cases of this disease in American-bred dogs. Affected and carrier status of dogs were determined by measuring the activity of the enzyme alpha-L-fucosidase in plasma and in leukocytes. Fucosidosis results in neurologic signs, particularly changes in behavior, in adolescent and adult dogs. Late onset of signs may result in misdiagnosis as a primary behavior problem ...
Tópico(s): Lysosomal Storage Disorders Research
1996 - American Veterinary Medical Association | Journal of the American Veterinary Medical Association
Andrew G. Burton, Dori L. Borjesson, William Vernau,
Abstract A 9‐year‐old female spayed English Springer Spaniel was evaluated for a cranial mediastinal mass and lymphocytosis. Flow cytometric immunophenotyping of peripheral blood lymphocytes revealed 97% as CD 3 positive, confirming a T‐cell lineage. Additionally, T‐cell subset assessment showed 53.2% to be double‐negative T‐lymphocytes, expressing neither CD 4 nor CD 8 surface markers. The number of double‐negative lymphocytes in circulation coincided with the number of T‐cell receptor ( TCR ) γδ‐expressing ...
Tópico(s): Veterinary Oncology Research
2014 - Wiley | Veterinary Clinical Pathology
BEVERLEY D. COTTRELL, K. C. Barnett,
ABSTRACT This paper reports 28 cases of primary angle closure glaucoma in the Welsh springer spaniel, a breed not previously reported to be affected by this condition. Females are affected more frequently than males (2–4:1). The age of onset ranges from 10 weeks to 10 years; however, the distribution is skewed towards the younger dog. The mode of inheritance appears to be dominant, which should make elimination of the trait through breeding control more straightforward. Gonioscopy on clinically affected ...
Tópico(s): Veterinary Oncology Research
1988 - Wiley | Journal of Small Animal Practice
John Berg, John M. Gliatto, Maura K. Wallace,
A 4-year-old Springer Spaniel was referred because of a 6-week history of progressive left forelimb lameness. A marked pain response was elicited by palpation over the left accessory carpal bone. Radiography revealed a lytic, markedly expansile lesion of the accessory carpal bone. The bone was excised, and pancarpal arthrodesis was performed. Histologic examination of the excised bone revealed giant cell tumor. At 14 months after surgery, the dog was using the limb normally. Radiography of the carpus ...
Tópico(s): Veterinary Orthopedics and Neurology
1990 - American Veterinary Medical Association | Journal of the American Veterinary Medical Association
Dylan N. Clements, Stuart M. McGill, Thierry Beths, Martin Sullivan,
An eight‐year‐old springer spaniel was presented with acute‐onset subcutaneous emphysema of five days’ duration. The dog had undergone ventral slot decompression of the C5‐C6 intervertebral disc space eight weeks before presentation. Cervical tracheoscopy demonstrated perforation of the dorsal tracheal membrane of the distal cervical trachea. Perforation of the dorsal tracheal membrane secondary to suture knot irritation was confirmed by exploratory surgery. Repair of the perforation was performed ...
Tópico(s): Trauma Management and Diagnosis
2003 - Wiley | Journal of Small Animal Practice
A five‐year‐old English springer spaniel was presented with a three year history of metacarpal ulceration causing lameness. The lesion was initially thought to be caused by a foreign body, but subsequently diagnosed as lymphangioma. The dog was surgically treated with resection of the metacarpal pad and transposition of the second digital pad. A severe infection developed 11 days postoperatively but was managed with antibiotics and intensive wound therapy. The surgical technique was successful, ...
Tópico(s): Vascular Malformations and Hemangiomas
1998 - Wiley | Journal of Small Animal Practice
Rosanne M. Taylor, I.C.A. Martin, B. R. H. Farrow,
Male English springer spaniel dogs affected with fucosidosis, a lysosomal storage disorder, were found to be infertile while females with the disease reproduced successfully. Ejaculates of semen collected from affected dogs had reduced total sperm output and morphologically abnormal spermatozoa. A high proportion of ejaculated spermatozoa had midpiece droplets, bent tails and poor motility. Severely vacuolated epididymal epithelial cells were observed by light microscopy. Electron microscopic examination ...
Tópico(s): Animal Genetics and Reproduction
1989 - Elsevier BV | Journal of Comparative Pathology
Joseph Alroy, U. Orgad, Angelo A. Ucci, Scott H. Schelling, Kenneth L. Schunk, Christopher D. Warren, Srinivasa S. Raghavan, Edwin H. Kolodny,
β-galactosidase-deficient siblings in two litters of English springer spaniel puppies showed a progressive neurological impairment, dwarfism, orbital hypertelorism, and dysostosis multiplex. An excess of G M1 -ganglioside was found in the brain. Three abnormal oligosaccharides were present in samples of urine, brain, liver, and cartilage. Light microscopy of selected tissue specimens revealed cytoplasmic vacuoles in neurons, circulating blood cells, macrophages, and chondrocytes. Ultrastructural ...
Tópico(s): Growth Hormone and Insulin-like Growth Factors
1985 - American Association for the Advancement of Science | Science
V. Galofaro, Giuseppe Rapisarda, Gerardo Ferrara, Nicola Maria Iannelli,
Contents A case of preputial glomangioma in an 8‐year‐old Springer Spaniel dog is reported. The dog presented a solitary nodular mass, approximately 3.5 × 5.2 cm in diameter, located on the lateral wall of the prepuce at the base of the penis. Histologically, the excised tumour mass consisted of proliferating round epithelioid cells arranged in a cordon‐like structure around small blood vessels. The neoplastic cells were positive for alpha smooth muscle actin and negative for cytokeratin, desmin, ...
Tópico(s): Soft tissue tumor case studies
2006 - Wiley | Reproduction in Domestic Animals
Julien Dandrieux, Katrin Timm, Petra Roosje, Monika Welle, Judith Howard, Andreas Brühschwein, Thierry Francey,
A 7 mo old female English springer spaniel was presented with diarrhea, vomiting, apathy, and hyperthermia. Further examinations revealed generalized lymphadenomegaly consistent with sterile neutrophilic-macrophagic lymphadenitis and pulmonary involvement. Subcutaneous nodules developed one day after presentation. Histology was consistent with sterile idiopathic nodular panniculitis and vasculitis. No infectious organism was isolated. The dog responded to prednisolone, but relapsed during medication ...
Tópico(s): Immunodeficiency and Autoimmune Disorders
2011 - American Animal Hospital Association | Journal of the American Animal Hospital Association
Carla Dedola, Alasdair P. G. Stuart, Alison E. Ridyard, Roderick W. Else, Adri H. M. van den Broek, Jong Soo Choi, G. Sybren de Hoog, Keith L. Thoday,
Abstract A 4‐year‐old, ovariohysterectomized, English springer spaniel on immunosuppressive therapy was re‐examined for the review of its immune‐mediated haemolytic anaemia and the recent development of skin lesions. For the 3 months since hospital discharge, the dog had been receiving 1.3 mg/kg prednisolone and 2.6 mg/kg ciclosporin, both administered orally twice daily. Physical examination revealed hepatomegaly and multiple, purulent, crusting, erosive to ulcerative lesions over different body ...
Tópico(s): Infectious Diseases and Mycology
2010 - Wiley | Veterinary Dermatology
Tim Charlesworth, Mark Dunning, T. Scase, D. M. Anderson,
An eight-month-old female English springer spaniel was presented with weight loss and severe haematochezia. Upper and lower endoscopy identified small intestinal inflammatory bowel disease and a vascular malformation within the descending colon. The colonic lesion was excised at coeliotomy and identified histopathologically as a colonic vascular ectasia. All clinical signs resolved following surgery and continued dietary management. To the authors' knowledge this is only the second published report ...
Tópico(s): Diverticular Disease and Complications
2012 - Wiley | Journal of Small Animal Practice