By DAVID WOOD, BY STAFF REPORTERS, By DAVID WILSWORTH, By STANLEY SADIE, FROM OUR CORRESPONDENT, BY A STAFF REPORTER, BY OUR CHURCHES CORRESPONDENT, By BEVIS HILLIER SALE ROOM CORRESPONDENT, By Nature-Times News Service, FROM OUR SCOTTISH CORRESPONDENT, By PETER HOPKIRK, By PHILIP HOWARD, By CLIVE BORRELL, BY OUR LEGAL CORRESPONDENT, FROM OUR CORRESPONDENT-Oxford, June 18, By GEOFFREY CHARLES., From INNIS MacBEATH-New York, June 18, FROM OUR OWN CORRESPONDENT-New York, June 18, FROM OUR OWN CORRESPONDENT, From DAVID BONAVIA, FROM A SPECIAL CORRESPONDENT, FROM OUR CORRESPONDENT-Prague, June 18, From EDWARD MORTIMER-Paris, June 18, From PATRICK BROGAN-Paris, June 18, From CHARLES HARGROVE-Saumur, June 18, From DAVID SPANIER-Washington, June 18, Rosemary Simon, Betty Cadbury Beaconwood. Rednal, Nr. Birmingham., June Rose, By HUGH NOYES-Westminster, Tuesday, PHS, HEDLEY ATKINS, Professor of Surgery at Guy's Hospital. Department of Surgery, Guy's Hospital, S.E.1, June 18., B. UMERAH, Royal Infirmary, Bristol., J. OKEKE, Morriston Hospital, Swansea. June 14., R. HIRJEE. 37 Milton Avenue, N.6, June 14., MILES THOMAS., FRANCIS SCARFE, Director, Institut Britannique de Paris, Université de Paris, Professor in the University of London, JAMES NOLAN. Solebury School, New Hope, Pa., U.S.A., By Max Beloff, Gladstone Professor of Government and Public Administration in the University of Oxford, R. B. ONIANS. Chalfont St. Giles, June 17., JOHN CARTER., W. A. BARKER., E. D. D. DICKSON. Chairman. Royal National Institute for the Deaf. 105 Gower Street, W.C.1., By JEROME CAMINADA, BY OUR HORTICULTURAL CORRESPONDENT, By Michael Billington, From VIVIAN JENKIN-Johannesburg, June 18, BY DENZIL BATCHELOR, By REX BELLAMY, Tennis Correspondent, By NORMAN PRESTON, BY ALAN GIBSON, By MICHAEL PHILLIPS, Racing Correspondent, By ANDREW PORTER, By JIM SNOW, By PAMELA MacGREGORMORRIS, By PETER RYDE, Golf Correspondent, By Our Real Tennis Correspondent, By GEOFFREY CHARLES, Motoring Correspondent, By KEITH PAYNE, By PETER JAY, Economics Editor, By BUSINESS NEWS STAFF, From DAVID SPANIER-, From R. W. SHAKESPEARE, By MICHAEL HATFIELD, By DAVID JONES, By MICHAEL BAILY, DAVID DAVIS, By RODNEY COWTON, By GEOFFREY CHARLES. Motoring Correspondent, BY OUR BANKING CORRESPONDENT, FROM OUR OWN CORRESPONDENT-Bonn, June 18, By CHRISTOPHER MEAKIN, B. C. TWISS. The College of Aeronautics, Cranfield, Bedford., R. J. JOHNSON. 11 Manor Road North, Hinchley Wood, Esher, Surrey., H. A. E. PITKIN, President, Federation of Registered House-Builders, 82 New Cavendish Street, London, W.1., MICHAEL IVENS. 13 Wessex Gardens, London. N.W.11., By JOHN CARRINGTON, By JOHN GILMORE, by A. M. Rendel, Diplomatic Correspondent, by Herman Goult Nicosia Correspondent, by a Special Correspondent, by Penelope Turing, by Arthur Reed, by Joyce Rackham, by A. Efthyvoulos, by Tom Hey, by Brian Hammond,
... Bank of Cyprus, Four Lanterns Hotel, Jack Barclay, Stafa, Nks, The Royal National Institute For The Deaf, ...
1968 - Gale Group | TDA
Salvatore J. Cherra, Erin Steer, Aaron M. Gusdon, Kirill Kiselyov, Charleen T. Chu,
... 25Ramonet D. Daher J.P. Lin B.M. Stafa K. Kim J. Banerjee R. Westerlund M. Pletnikova ... 25Ramonet D. Daher J.P. Lin B.M. Stafa K. Kim J. Banerjee R. Westerlund M. Pletnikova ... 25Ramonet D. Daher J.P. Lin B.M. Stafa K. Kim J. Banerjee R. Westerlund M. Pletnikova ...
Tópico(s): Genetic Neurodegenerative Diseases
2012 - Elsevier BV | American Journal Of Pathology
Pia Maria van gen Hassend, Aparna Pottikkadavath, Carolyn Delto, Monika Kuhn, Michelle Endres, Lars Schönemann, Hermann Schindelin,
... been further implicated in cell proliferation (20Lampert F. Stafa D. Goga A. Soste M.V. Gilberto S. ... not targeted by the CTLH complex (20Lampert F. Stafa D. Goga A. Soste M.V. Gilberto S. ... replace their paralogs Rmnd5a and RanBP9 (20Lampert F. Stafa D. Goga A. Soste M.V. Gilberto S. ...
Tópico(s): Glycosylation and Glycoproteins Research
2023 - Elsevier BV | Journal of Biological Chemistry
Catherine Baroffio, W. Siegfried, Urs Hilber,
... hydroxyanilide fenhexamid in experimental vineyards in Richterswil and Stäfa, Switzerland. In total, over 2,400 field isolates ... of fenhexamid-resistant isolates increased to 100% in Stäfa. The analysis of monitoring and efficacy data showed ...
Tópico(s): Plant Disease Resistance and Genetics
2003 - American Phytopathological Society | Plant Disease
Nhung Pham, Zhenxin Yan, Yang Yu, Mosammat Faria Afreen, Anna Malkova, James E. Haber, Grzegorz Ira,
... Smith et al, 2007; Anand et al, 2014; Stafa et al, 2014). The increase of point mutations ... Sun et al, 2008; Prakash et al, 2009; Stafa et al, 2014; Piazza et al, 2019), likely ...
Tópico(s): DNA and Nucleic Acid Chemistry
2021 - Springer Nature | The EMBO Journal
Daniel A. Ramras, Mentor Stafa,
... and $B_{\textrm{com}} G$, introduced by Cohen–Stafa and Adem–Cohen–Torres-Giese, respectively. In addition, ...
Tópico(s): Advanced Algebra and Geometry
2020 - Oxford University Press | International Mathematics Research Notices
... 7[2]:41; Hearing Care for Adults 2006. Stafa, Switzerland: Phonak AG; 2007.) A plethora of evidence ... Care for Adults 2009-The Challenge of Aging, Stafa, Switzerland: Phonak AG; 2009; Evidence Based Practice in ... Care for Adults 2009-The Challenge of Aging, Stafa, Switzerland: Phonak AG; 2009.) The groups fitted with ... Care for Adults 2009-The Challenge of Aging, Stafa, Switzerland: Phonak AG; 2009.) These norms make it ...
Tópico(s): Hearing Loss and Rehabilitation
2012 - Lippincott Williams & Wilkins | The Hearing Journal
G. Bayer, Hans‐Georg Wiedemann,
... Eintritt in die Firma Mettler Instrumente AG in Stäfa/Schweiz. Dort arbeitete er an der Konzeption und ... Eintritt in die Firma Mettler Instrumente AG in Stäfa/Schweiz. Dort arbeitete er an der Konzeption und ...
Tópico(s): History and advancements in chemistry
1985 - Wiley | Chemie in unserer Zeit
Klodjan Stafa, Elpida Tsika, Roger Moser, Alessandra Musso, Liliane Glauser, Amy Jones, Saskia Biskup, Yulan Xiong, Rina Bandopadhyay, Valina L. Dawson, Ted M. Dawson, Darren J. Moore,
Mutations in LRRK2 cause autosomal dominant Parkinson's disease (PD). LRRK2 encodes a multi-domain protein containing GTPase and kinase domains, and putative protein-protein interaction domains. Familial PD mutations alter the GTPase and kinase activity of LRRK2 in vitro. LRRK2 is suggested to regulate a number of cellular pathways although the underlying mechanisms are poorly understood. To explore such mechanisms, it has proved informative to identify LRRK2-interacting proteins, some of which serve ...
Tópico(s): Alzheimer's disease research and treatments
2013 - Oxford University Press | Human Molecular Genetics
Berislav Lisnić, Ivan‐Krešimir Svetec, Anamarija Štafa, Zoran Zgaga,
Palindromic and quasi-palindromic sequences are important DNA motifs found in various cis-acting genetic elements, but are also known to provoke different types of genetic alterations. The instability of such motifs is clearly size-related and depends on their potential to adopt secondary structures known as hairpins and cruciforms. Here we studied the influence of palindrome size on recombination between two directly repeated copies of the yeast CYC1 gene leading to the loss of the intervening ...
Tópico(s): Fungal and yeast genetics research
2009 - Elsevier BV | DNA repair
... many of these studies, Dr. Hans-Georg Wiedemann, Stäfa, Switzerland, who introduced me to the field of ...
Tópico(s): Dye analysis and toxicity
2002 - Wiley | Angewandte Chemie International Edition
Mihaela Bradić, Sanja Sikora, Sulejman Redžepović, Zvonimir Štafa,
Summary Soil bacteria Sinorhizobium meliloti are of enormous agricultural value, because of their ability to fix atmospheric nitrogen in symbiosis with an important forage crop legume – alfalfa. The main aim of this study was (i) to isolate indigenous S. meliloti strains from different field sites in Croatia, (ii) to assess genetic diversity and genetic relationships amongst strains of natural populations and (iii) to provide information about nodulation and symbiotic efficiency of indigenous S. meliloti ...
Tópico(s): Legume Nitrogen Fixing Symbiosis
2003 - University of Zagreb | Food Technology and Biotechnology
Intracranial aneurysms are common lesions with an adult prevalence rate between one and five percent in autopsy studies 1. Fortunately, most aneurysms are small and an estimated 50 to 80 percent of all aneurysms do not rupture during the course of a person's lifetime 2. Intracranial aneurysms are considered to be sporadically acquired lesions, although a rare familiar form has been described3. Clinically, cerebral aneurysms can be silent or give rise to focal neurological symptoms or rupture leading ...
Tópico(s): Cerebrovascular and Carotid Artery Diseases
2008 - SAGE Publishing | Interventional Neuroradiology
David M. Pelz, Elad I. Levy, L. Nelson Hopkins,
... L, Dall'Olio M, Princiotta C, Simonetti L, Stafa A and Leonardi F (2010) The Use of ...
Tópico(s): Acute Ischemic Stroke Management
2008 - Lippincott Williams & Wilkins | Stroke
Venkateswaran Ramesh, Bruno De Bernardi, A. Stafa, Caterina Garone, Emilio Franzoni, Mario Abinun, Patrick Mitchell, Dipayan Mitra, Mark Friswell, John W. Nelson, Stavit A. Shalev, Gillian Rice, Hannah Gornall, Marcin Szynkiewicz, FRANÇOIS AYMARD, Vijeya Ganesan, Julie Prendiville, John H. Livingston, Yanick J. Crow,
Aim To describe a spectrum of intracerebral large artery disease in Aicardi–Goutières syndrome (AGS) associated with mutations in the AGS5 gene SAMHD1 . Method We used clinical and radiological description and molecular analysis. Results Five individuals (three males, two females) were identified as having biallelic mutations in SAMHD1 and a cerebral arteriopathy in association with peripheral vessel involvement resulting in chilblains and ischaemic ulceration. The cerebral vasculopathy was primarily ...
Tópico(s): Connective tissue disorders research
2010 - Wiley | Developmental Medicine & Child Neurology
Luigi Cirillo, M. Dall’Olio, Ciro Princiotta, L. Simonetti, A. Stafa, Francesco Toni,
The treatment of giant cerebral aneurysms has always been a challenge for neurosurgeons and neuroradiologists. Flow-diverting stents (Silk; Pipeline Embolization Device) are new endovascular devices introduced for the treatment of intracranial aneurysms without release of intrasaccular coils. They are tubular bimetallic endoluminal devices with low porosity. We have employed these stents in the Neuroradiology Unit of Bellaria Hospital (Bologna, Italy) since the end of 2008, treating nine patients ...
Tópico(s): Cerebrovascular and Carotid Artery Diseases
2010 - SAGE Publishing | The Neuroradiology Journal
Ivan‐Krešimir Svetec, Anamarija Štafa, Zoran Zgaga,
Abstract We investigated the influence of short terminal heterologies on recombination between transforming linear DNA fragments and the yeast Saccharomyces cerevisiae genome. The efficiency of plasmid integration to the CYC1 locus (ends‐in assay) was decreased more than five‐fold when the size of terminal heterology exceeded 28 nucleotides (nt) and a similar inhibitory effect was also observed in the ends‐out assay (replacement of the ura3‐52 allele by the URA3 gene). Plasmid integration occurred ...
Tópico(s): Plant tissue culture and regeneration
2007 - Wiley | Yeast
David Ramonet, Agata Podhajska, Klodjan Stafa, Sarah Sonnay, Alžbeta Trančíková, Elpida Tsika, Olga Pletniková, Juan C. Troncoso, Liliane Glauser, Darren J. Moore,
Mutations in the ATP13A2 gene (PARK9, OMIM 610513) cause autosomal recessive, juvenile-onset Kufor-Rakeb syndrome and early-onset parkinsonism. ATP13A2 is an uncharacterized protein belonging to the P5-type ATPase subfamily that is predicted to regulate the membrane transport of cations. The physiological function of ATP13A2 in the mammalian brain is poorly understood. Here, we demonstrate that ATP13A2 is localized to intracellular acidic vesicular compartments in cultured neurons. In the human brain, ...
Tópico(s): Botulinum Toxin and Related Neurological Disorders
2011 - Oxford University Press | Human Molecular Genetics
Produção Nacional
Revisado por pares
David Ramonet, João Paulo Lima Daher, Brian M. Lin, Klodjan Stafa, Jaekwang Kim, Rebecca Banerjee, Marie Westerlund, Olga Pletniková, Liliane Glauser, Lichuan Yang, Ying Liu, Deborah A. Swing, M. Flint Beal, Juan C. Troncoso, J. Michael McCaffery, Nancy A. Jenkins, Neal G. Copeland, Dagmar Galter, Bobby Thomas, Michael K. Lee, Ted M. Dawson, Valina L. Dawson, Darren J. Moore,
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene cause late-onset, autosomal dominant familial Parkinson's disease (PD) and also contribute to idiopathic PD. LRRK2 mutations represent the most common cause of PD with clinical and neurochemical features that are largely indistinguishable from idiopathic disease. Currently, transgenic mice expressing wild-type or disease-causing mutants of LRRK2 have failed to produce overt neurodegeneration, although abnormalities in nigrostriatal dopaminergic ...
Tópico(s): Neurological disorders and treatments
2011 - Public Library of Science | PLoS ONE
Matilde Leonardi, Luigi Cirillo, Francesco Toni, M. Dall’Olio, Ciro Princiotta, A. Stafa, L. Simonetti, R. Agati,
The Silk stent (Balt, Montmorency, France) is a retractable device designed to achieve curative reconstruction of the parent artery associated with an intracranial aneurysm. We present our initial experience with the Silk flow-diverting stent in the management and follow-up of 25 patients presenting with intracranial aneurysms. Twenty-five patients (age range, 34–81 years; 24 female) were treated with the Silk flow-diverting device. Aneurysms ranged in size from small (5), large (10) and giant (10) and ...
Tópico(s): Vascular Malformations Diagnosis and Treatment
2011 - SAGE Publishing | Interventional Neuroradiology
Julien Dusonchet, Olexiy Kochubey, Klodjan Stafa, Samuel Young, Romain Zufferey, Darren J. Moore, Bernard L. Schneider, Patrick Aebischer,
The G2019S mutation in the leucine-rich repeat kinase 2 (LRRK2) gene is the most common genetic cause of Parkinson's disease (PD), accounting for a significant proportion of both autosomal dominant familial and sporadic PD cases. Our aim in the present study is to generate a mammalian model of mutant G2019S LRRK2 pathogenesis, which reproduces the robust nigral neurodegeneration characteristic of PD. We developed adenoviral vectors to drive neuron-specific expression of full-length wild-type or mutant ...
Tópico(s): Nerve injury and regeneration
2011 - Society for Neuroscience | Journal of Neuroscience
Liliane Glauser, Sarah Sonnay, Klodjan Stafa, Darren J. Moore,
Mutations in the parkin gene cause early-onset, autosomal recessive Parkinson's disease. Parkin functions as an E3 ubiquitin ligase to mediate the covalent attachment of ubiquitin monomers or linked chains to protein substrates. Substrate ubiquitination can target proteins for proteasomal degradation or can mediate a number of non-degradative functions. Parkin has been shown to preserve mitochondrial integrity in a number of experimental systems through the regulation of mitochondrial fission. Upon ...
Tópico(s): Mitochondrial Function and Pathology
2011 - Wiley | Journal of Neurochemistry
Klodjan Stafa, Alžbeta Trančíková, Philip J. Webber, Liliane Glauser, Andrew B. West, Darren J. Moore,
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most common cause of autosomal dominant familial Parkinson's disease (PD) and also contribute to idiopathic PD. LRRK2 encodes a large multi-domain protein with GTPase and kinase activity. Initial data indicates that an intact functional GTPase domain is critically required for LRRK2 kinase activity. PD-associated mutations in LRRK2, including the most common G2019S variant, have variable effects on enzymatic activity but commonly alter ...
Tópico(s): Retinal Development and Disorders
2012 - Public Library of Science | PLoS Genetics
Agata Podhajska, Alessandra Musso, Alžbeta Trančíková, Klodjan Stafa, Roger Moser, Sarah Sonnay, Liliane Glauser, Darren J. Moore,
Mutations in the ATP13A2 gene (PARK9) cause autosomal recessive, juvenile-onset Kufor-Rakeb syndrome (KRS), a neurodegenerative disease characterized by parkinsonism. KRS mutations produce truncated forms of ATP13A2 with impaired protein stability resulting in a loss-of-function. Recently, homozygous and heterozygous missense mutations in ATP13A2 have been identified in subjects with early-onset parkinsonism. The mechanism(s) by which missense mutations potentially cause parkinsonism are not understood ...
Tópico(s): Alzheimer's disease research and treatments
2012 - Public Library of Science | PLoS ONE
Alžbeta Trančíková, Adamantios Mamais, Philip J. Webber, Klodjan Stafa, Elpida Tsika, Liliane Glauser, Andrew B. West, Rina Bandopadhyay, Darren J. Moore,
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are a common cause of autosomal dominant familial Parkinson's disease (PD). LRRK2 encodes a multi-domain protein containing GTPase and kinase enzymatic domains. Disease-associated mutations in LRRK2 variably influence enzymatic activity with the common G2019S variant leading to enhanced kinase activity. Mutant LRRK2 induces neuronal toxicity through a kinase-dependent mechanism suggesting that kinase activity is important for mediating the ...
Tópico(s): Plant Gene Expression Analysis
2012 - Public Library of Science | PLoS ONE
Luigi Cirillo, Matilde Leonardi, M. Dall’Olio, Ciro Princiotta, A. Stafa, L. Simonetti, Francesco Toni, R. Agati,
Flow-diverting stents (Silk and PED) have radically changed the approach to intracranial aneurysm treatment from the use of endosaccular materials to use of an extraaneurysmal endoluminal device. However, much debate surrounds the most appropriate indications for the use of FD stents and the problems raised by several possible complications. We analysed our technical difficulties and the early (less than ten days after treatment) and late complications encountered in 30 aneurysms treated comprising ...
Tópico(s): Meningioma and schwannoma management
2012 - SAGE Publishing | Interventional Neuroradiology
Silvia Stagni, F. De Santis, Luigi Cirillo, M. Dall’Olio, Ciro Princiotta, L. Simonetti, A. Stafa, Marco Leonardi,
A multitude of therapies is available to treat disc herniation, ranging from conservative methods (medication and physical therapy) to minimally invasive (percutaneous) treatments and surgery. O 2 -O 3 chemonucleolysis (O 2 -O 3 therapy) is one of the minimally invasive treatments with the best cost/benefit ratio and lowest complication rate. Another substance recently made available exploiting the chemical properties of pure ethanol is DiscoGel®, a radiopaque gelified ethanol more viscous than absolute ...
Tópico(s): Anesthesia and Pain Management
2012 - SAGE Publishing | Interventional Neuroradiology
Josip Leto, Mladen Knežević, Krešimir Bošnjak, Dubravko Mačešić, Zvonimir Štafa, Vinko Kozumplik,
Six Trifolium pratense L. cultivars, five diploid and one tetraploid, were grown in the lowland region (123 m altitude) and the mountain region (650 m altitude). Dry matter (d.m.) and green mass (g.m.) yield, stem height and leaf proportion were assessed from each of the three growing seasons. Chemical composition was assessed from the average samples of all cuts in the second year of the experiment. Greater green mass (54.14 t/ha) and dry matter yield (9.86 t/ha), stem height (0.61 m), crude protein (157. ...
Tópico(s): Plant pathogens and resistance mechanisms
2004 - Czech Academy of Agricultural Sciences | Plant Soil and Environment
Nripesh Dhungel, Simona Eleuteri, Ling-bo Li, Nicholas J. Kramer, Justin W. Chartron, Brian Spencer, Kori Kosberg, Jerel Adam Fields, Klodjan Stafa, Anthony Adame, Hilal A. Lashuel, Judith Frydman, Kang Shen, Eliezer Masliah, Aaron D. Gitler,
Parkinson’s disease (PD) is a common neurodegenerative disorder. Functional interactions between some PD genes, like PINK1 and parkin, have been identified, but whether other ones interact remains elusive. Here we report an unexpected genetic interaction between two PD genes, VPS35 and EIF4G1. We provide evidence that EIF4G1 upregulation causes defects associated with protein misfolding. Expression of a sortilin protein rescues these defects, downstream of VPS35, suggesting a potential role for sortilins ...
Tópico(s): Nerve injury and regeneration
2014 - Cell Press | Neuron
Mariska Stam, Piet J. Kostense, Ulrike Lemke, Paul Merkus, Johannes H. Smit, Joost Μ. Festen, Sophia E. Kramer,
... Amsterdam, The Netherlandsc Phonak AG, Science and Technology, Stäfa, Switzerlandd Department of Psychiatry, VU University Medical Center/ ...
Tópico(s): Noise Effects and Management
2014 - Taylor & Francis | International Journal of Audiology