Nicole Dalia Cilia, Giuseppe De Gregorio, Claudio De Stefano, Francesco Fontanella, Angelo Marcelli, Antonio Parziale,
Neurodegenerative diseases are caused by the progressive degeneration of nerve cells that affect motor skills and cognitive abilities with increasing severity. Unfortunately, there is no cure for this type of disease and their impact can only be slowed down with specific pharmacological and rehabilitative therapies. Early diagnosis, therefore, remains the primary means to delay brain damage and improve the quality of life of people affected. Neurodegenerative diseases also affect movement fine control. ...
Tópico(s): Hand Gesture Recognition Systems
2022 - Elsevier BV | Engineering Applications of Artificial Intelligence
Danilo De Gregorio, Stefano Comai, Luca Posa, Gabriella Gobbi,
d-Lysergic Acid Diethylamide (LSD) is known for its hallucinogenic properties and psychotic-like symptoms, especially at high doses. It is indeed used as a pharmacological model of psychosis in preclinical research. The goal of this review was to understand the mechanism of action of psychotic-like effects of LSD. We searched Pubmed, Web of Science, Scopus, Google Scholar and articles’ reference lists for preclinical studies regarding the mechanism of action involved in the psychotic-like effects ...
Tópico(s): Biochemical Analysis and Sensing Techniques
2016 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Susanne Ettinger, Loïc Mounaud, Christina Magill, Anne-Françoise Yao-Lafourcade, J. C. Thouret, V. Manville, Caterina Negulescu, Giulio Zuccaro, Daniela De Gregorio, Stefano Nardone, Juan Alexis Luque Uchuchoque, Anita Arguedas, Luisa Macedo, Nélida Manrique Llerena,
The focus of this study is an analysis of building vulnerability through investigating impacts from the 8 February 2013 flash flood event along the Avenida Venezuela channel in the city of Arequipa, Peru. On this day, 124.5 mm of rain fell within 3 h (monthly mean: 29.3 mm) triggering a flash flood that inundated at least 0.4 km2 of urban settlements along the channel, affecting more than 280 buildings, 23 of a total of 53 bridges (pedestrian, vehicle and railway), and leading to the partial collapse ...
Tópico(s): Landslides and related hazards
2015 - Elsevier BV | Journal of Hydrology
Angelica Galieni, Carla Di Mattia, Miriam De Gregorio, Stefano Speca, Dino Mastrocola, Michele Pisante, Fabio Stagnari,
Plants of lettuce were subjected to four abiotic limiting growing conditions, i.e. no phosphorus fertilization (0_P), no nitrogen fertilization (0_N), limitation of the photosynthetic active radiation (PAR, range from 400 to 700 nm) (LR) and water availability constraint (WR). Yield, yield components, root growth, bound and soluble phenolic compounds accumulation and their antiradical activity were investigated. Leaf length decreased by 21% in 0_N while increased by 57% in LR with respect to CONTROL ...
Tópico(s): Plant Stress Responses and Tolerance
2015 - Elsevier BV | Scientia Horticulturae
Alessandro De Gregorio, Stefano M. Iacus,
The least absolute shrinkage and selection operator (LASSO) is a widely used statistical methodology for simultaneous estimation and variable selection. It is a shrinkage estimation method that allows one to select parsimonious models. In other words, this method estimates the redundant parameters as zero in the large samples and reduces variance of estimates. In recent years, many authors analyzed this technique from a theoretical and applied point of view. We introduce and study the adaptive LASSO ...
Tópico(s): Bayesian Methods and Mixture Models
2012 - Cambridge University Press | Econometric Theory
Alessandro De Gregorio, Stefano M. Iacus,
In this paper, we derive explicit formulas of the Rényi information, Shannon entropy and Song measure for the invariant density of one dimensional ergodic diffusion processes. In particular, the diffusion models considered include the hyperbolic, the generalized inverse Gaussian, the Pearson, the exponential family and a new class of skew-t diffusions.
Tópico(s): Statistical Mechanics and Entropy
2008 - Elsevier BV | Information Sciences
Alessandro De Gregorio, Stefano M. Iacus,
A one-dimensional diffusion process X = {X t , 0 ≤ t ≤ T}, with drift b(x) and diffusion coefficient known up to θ > 0, is supposed to switch volatility regime at some point t* ∈ (0,T). On the basis of discrete time observations from X, the problem is the one of estimating the instant of change in the volatility structure t* as well as the two values of θ, say θ1 and θ2, before and after the change point. It is assumed that the sampling occurs at regularly spaced times intervals of length Δ n with nΔ n = T. To ...
Tópico(s): Statistical Methods and Inference
2008 - Taylor & Francis | Communication in Statistics- Theory and Methods
Alessandro De Gregorio, Stefano M. Iacus,
The telegraph process X(t), t ≥ 0, (Goldstein, Q J Mech Appl Math 4:129–156, 1951) and the geometric telegraph process $$S(t) = s_{0} {\rm exp}\{(\mu -\frac12\sigma^{2})t + \sigma X(t)\}$$ with μ a known real constant and σ > 0 a parameter are supposed to be observed at n + 1 equidistant time points t i = iΔ n ,i = 0,1,..., n. For both models λ, the underlying rate of the Poisson process, is a parameter to be estimated. In the geometric case, also σ > 0 has to be estimated. We propose different estimators of the parameters ...
Tópico(s): Statistical Methods and Inference
2007 - Springer Science+Business Media | Statistical Inference for Stochastic Processes
Giuseppe Gorini, G. De Gregorio, Stefano Silvestri, Elisabetta Chellini, Vincenzo Cupelli, Adele Seniori Costantini,
This study analyses survival of Tuscan residents (Italy, 3.5 million population) diagnosed by histological examination with malignant pleural mesothelioma (MPM) during the period 1988-2000, and recorded in the Tuscan Malignant Mesothelioma Register. The aim was to establish the prognostic role of demographic, diagnostic and asbestos exposure variables. During 1988-2000, 381 MPM cases were recorded (318 men; 63 women). Vital status was ascertained up to 31 December 2002. No cases were lost to follow- ...
Tópico(s): Radiation Dose and Imaging
2005 - Lippincott Williams & Wilkins | European Journal of Cancer Prevention
Alberto Arnone, Cristiana De Gregorio, Stefano V. Meille, Gianluca Nasini, Giancarlo Sidoti,
Tsugicoline E (3) has been isolated from cultures of the Basidiomycetous fungus Laurilia tsugicola and its structure deduced from 1H and 13C NMR and single-crystal X-ray diffraction studies. The suggested absolute configuration is consistent with biogenetic considerations.
Tópico(s): Marine Sponges and Natural Products
1998 - American Chemical Society | Journal of Natural Products
Manuela Gariboldi, Elena Maestrini, Federico Canzian, Giacomo Manenti, Laura De Gregorio, Stefano Rivella, Aurobindo Chatterjee, Gail E. Herman, Nicoletta Archidiacono, Rachele Antonacci, Marco A. Pierotti, Tommaso A. Dragani, Daniela Toniolo,
Two genes encode actin-binding protein 280 isoforms. ABP-280 or filamin (FLN1) is present in the cytoskeleton of many cell types, whereas expression of FLN2 is limited to skeletal muscle and heart. FLN1 maps to human chromosome Xq28, and, by physical mapping in YAC clones, we have mapped the homologous murine locus (Fln1) to mouse chromosome X, in a region of syntenic homology with human chromosome X. We mapped FLN2 to human chromosome 7q32-q35 by analysis of somatic cell hybrids containing portions ...
Tópico(s): Genomics and Chromatin Dynamics
1994 - Elsevier BV | Genomics
Giuseppe Privitera, Giovanni Battista Ciottoli, Carmelo Patañe, Tullio Palmucci, Gaetano Tafuri, Francesco Marletta, Bruno De Luca, Francesco Magnani, M. De Gregorio, Stefano Greco,
Patients with non metastatic squamous cell lung cancer were treated with radiotherapy (RT) plus lonidamine (LND) or placebo (PLAC), according to a randomized double-blind study design. Treatment with lonidamine 150 mg t.i.d (27 patients) or placebo (23 patients) started 3 days before RT,lasted up to 7 months. Partial responses were observed in 14 and 6 patients respectively in the LND+RT and PLAC+RT groups. Statistical analysis of the survival curves showed no significant difference between the LND+RT ( ...
Tópico(s): Cancer therapeutics and mechanisms
1987 - Elsevier BV | Radiotherapy and Oncology
Alessandro De Gregorio, Stefano M. Iacus,
A new distance to classify time series is proposed. The underlying generating process is assumed to be a diffusion process solution to stochastic differential equations and observed at discrete times. The mesh of observations is not required to shrink to zero. The new dissimilarity measure is based on the L1 distance between the Markov operators estimated on two observed paths. Simulation experiments are used to analyze the performance of the proposed distance under several conditions including ...
Tópico(s): Financial Risk and Volatility Modeling
2009 - Elsevier BV | Computational Statistics & Data Analysis
Marco Onofrj, Mirella Russo, Stefano Delli Pizzi, Danilo De Gregorio, Antonio Inserra, Gabriella Gobbi, Stefano L. Sensi,
Abstract The PD-DLB psychosis complex found in Parkinson’s disease (PD) and Dementia with Lewy Bodies (DLB) includes hallucinations, Somatic Symptom/Functional Disorders, and delusions. These disorders exhibit similar presentation patterns and progression. Mechanisms at the root of these symptoms also share similarities with processes promoting altered states of consciousness found in Rapid Eye Movement sleep, psychiatric disorders, or the intake of psychedelic compounds. We propose that these mechanisms ...
Tópico(s): Tryptophan and brain disorders
2023 - Springer Nature | Translational Psychiatry
Alessandro De Gregorio, Stefano M. Iacus,
The telegraph process models a random motion with finite velocity and it is usually proposed as an alternative to diffusion models. The process describes the position of a particle moving on the real line, alternatively with constant velocity+v or−v. The changes of direction are governed by a homogeneous Poisson process with rate λ>0. In this paper, we consider a change-point estimation problem for the rate of the underlying Poisson process by means of the least-squares method under the hypothesis ...
Tópico(s): Stochastic processes and financial applications
2010 - Taylor & Francis | Statistics
Alessandro De Gregorio, Stefano M. Iacus,
We consider parametric hypotheses testing for multidimensional ergodic diffusion processes observed at discrete time. We propose a family of test statistics related to the so called ϕ-divergence measures. It is proved that the test statistics in this family are all asymptotically distribution free and converge to the chi squared distribution. In the case of contiguous alternatives, it is also possible to study in detail the power function of the tests. Although all the tests in this family are asymptotically ...
Tópico(s): Bayesian Methods and Mixture Models
2013 - Elsevier BV | Journal of Multivariate Analysis
Stefano Comai, Danilo De Gregorio, Luca Posa, Rafael Ochoa‐Sanchez, Annalida Bedini, Gabriella Gobbi,
Abstract Melatonin (MLT) levels fluctuate according to the external light/dark cycle in both diurnal and nocturnal mammals. We previously demonstrated that melatonin MT 2 receptor knockout (MT 2 −/− ) mice show a decreased nonrapid eye movement sleep over 24 hours and increased wakefulness during the inactive (light) phase. Here, we investigated the role of MT 2 receptors in physiological light/dark cycle fluctuations in the activity of dorsal raphe nucleus (DRN) serotonin (5‐HT) neurons and anxiety‐ and depression‐ ...
Tópico(s): Neuroendocrine regulation and behavior
2020 - Wiley | Journal of Pineal Research
Antonella Tosco, Fabiola De Gregorio, Speranza Esposito, Daniela De Stefano, Ilenia Sana, Eleonora Ferrari, Angela Sepe, Laura Salvadori, Paolo Buonpensiero, A. Di Pasqua, Rosa Grassia, Carlo Antonio Leone, Stefano Guido, Giuseppe De Rosa, Sara Lusa, Gianni Bona, Gautier Stoll, Maria Chiara Maiuri, Anil Mehta, Guido Kroemer, Luigi Maiuri, Valeria Raia,
We previously reported that the combination of two safe proteostasis regulators, cysteamine and epigallocatechin gallate (EGCG), can be used to improve deficient expression of the cystic fibrosis transmembrane conductance regulator (CFTR) in patients homozygous for the CFTR Phe508del mutation. Here we provide the proof-of-concept that this combination treatment restored CFTR function and reduced lung inflammation (P<0.001) in Phe508del/Phe508del or Phe508del/null-Cftr (but not in Cftr-null mice), provided ...
Tópico(s): Cystic Fibrosis Research Advances
2016 - Springer Nature | Cell Death and Differentiation
Nagaraja Chappidi, Giuseppe De Gregorio, Stefano Ferrari,
Mechanisms controlling DNA resection at sites of damage and affecting genome stability have been the subject of deep investigation, though their complexity is not yet fully understood. Specifically, the regulatory role of post-translational modifications in the localization, stability and function of DNA repair proteins is an important aspect of such complexity.Here, we took advantage of the superior resolution of phosphorylated proteins provided by Phos-Tag technology to study pathways controlling ...
Tópico(s): 14-3-3 protein interactions
2019 - BioMed Central | Cell Division
Antonio Di Zazzo, Giuseppe Varacalli, Chiara De Gregorio, Marco Coassin, Stefano Bonini,
Purpose: The purpose of this article was to compare clinical outcomes between therapeutic penetrating keratoplasty (TPK), therapeutic deep anterior lamellar keratoplasty (TDALK), and optical penetrating keratoplasty (OPK) in Acanthamoeba keratitis. Methods: A literature search was conducted in online libraries from 1980 to 2021. The primary end points were best-corrected visual acuity (VA), graft survival, and infection recurrence. In addition, we enrolled 35 consecutive patients with AK from our practice ...
Tópico(s): Ocular Surface and Contact Lens
2021 - Lippincott Williams & Wilkins | Cornea
Luca Posa, Danilo De Gregorio, Gabriella Gobbi, Stefano Comai,
Melatonin (MLT) has been implicated in several pathophysiological states, including pain. MLT mostly activates two G-protein coupled receptors, MT1 and MT2. In this review, we present the analgesic properties of MLT in preclinical and clinical studies, giving particular emphasis to the effects mediated by MT2 receptors and to recent investigations demonstrating the analgesic effects of MT2 receptor partial agonists in chronic and acute/inflammatory pain conditions. MT2 receptors are localized in ...
Tópico(s): Neuroendocrine regulation and behavior
2017 - Bentham Science Publishers | Current Medicinal Chemistry
Giovanni Castellazzi, Enrico Cardillo, Nicolò Lo Presti, Antonio Maria D’Altri, Stefano de Miranda, Gregorio Bertani, Francesca Ferretti, Claudio Mazzotti,
Preserving and managing historical cultural heritage necessitates innovative approaches that harmonize technology with historical documentation. This paper presents a case study showcasing an adaptable online database tailored for the incorporation of Building Information Modeling (BIM) models and associated historical records. Notably, this approach offers distinctive integration with historical data, enabling users to contextualize heritage assets historically. The study delves into the database’ ...
Tópico(s): Conservation Techniques and Studies
2023 - Multidisciplinary Digital Publishing Institute | Heritage
Fabio De Gregorio, J Pecori-Giraldi, C. De Stefano, M Virno,
In 35 patients with bilateral primary open-angle glaucoma (POAG), with asymmetrical evolution of the neuropticopathy between the two eyes, we compared within each patient, the response to ibopamine and the perimetric defect. In 88% of cases (31/35 patients) the eye with the most severe perimetric defect had high intraocular pressure or a larger IOP increase after ibopamine. This result was highly significant at the sign test (P<0.001). IOP and its increase after ibopamine significantly differed ...
Tópico(s): Ophthalmology and Eye Disorders
1997 - SAGE Publishing | European Journal of Ophthalmology
... 221.CrossrefMedlineGoogle Scholar5 Borgna-Pignatti C, Rugolotto S, De Stefano P, Piga A, Di Gregorio F, Gamberini MR, Sabato V, Melevendi C, Cappellini MD, Verlato G. Survival and disease complications in thalassemia major. Ann N Y Acad Sci. 1998; 850: 227–231.CrossrefMedlineGoogle Scholar6 Brittenham GM, Griffith PM, Nienhuis AW, McLaren CE, Young NS, Tucker EE, Allen CJ, Farrell DE, Harris JW. Efficacy of deferoxamine in preventing complications ...
Tópico(s): Autopsy Techniques and Outcomes
2009 - Lippincott Williams & Wilkins | Circulation
Khawla Mohammed Belhoul, Maisan Lateef Bakir, Ahmed Mohamed Kadhim, Hany Dewedar, Mohamed Salah Eldin, Fatheya Abbas AlKhaja,
... ARTICLE REFERENCES:1. Borgna-Pignatti C, Rugolotto S, De Stefano P, Piga A, Di Gregorio F, Gamberini MR, et al. "Survival and disease ...
Tópico(s): Iron Metabolism and Disorders
2013 - King Faisal Specialist Hospital and Research Centre | Annals of Saudi Medicine
Daniele De Gregorio, Gianluca Palli, Luigi Di Stefano,
While robotic manipulation of rigid objects is quite straightforward, coping with deformable objects is an open issue. More specifically, tasks like tying a knot, wiring a connector or even surgical suturing deal with the domain of Deformable Linear Objects (DLOs). In particular the detection of a DLO is a non-trivial problem especially under clutter and occlusions (as well as self-occlusions). The pose estimation of a DLO results into the identification of its parameters related to a designed model, ...
Tópico(s): Image Retrieval and Classification Techniques
2019 - Springer Science+Business Media | Lecture notes in computer science
E. Sanchis, L. Testi, A. Natta, C. F. Manara, Barbara Ercolano, T. Preibisch, Thomas Henning, Stefano Facchini, A. Miotello, I. de Gregorio‐Monsalvo, C. López, K. Mužić, Ilaria Pascucci, Alejandro Santamaría-Miranda, A. Scholz, Marco Tazzari, Sierk van Terwisga, Jonathan P. Williams,
We present new 890 $\mu m$ continuum ALMA observations of 5 brown dwarfs (BDs) with infrared excess in Lupus I and III -- which, in combination with 4 BDs previously observed, allowed us to study the mm properties of the full known BD disk population of one star-forming region. Emission is detected in 5 out of the 9 BD disks. Dust disk mass, brightness profiles and characteristic sizes of the BD population are inferred from continuum flux and modeling of the observations. Only one source is marginally ...
Tópico(s): Astro and Planetary Science
2019 - EDP Sciences | Astronomy and Astrophysics
Giovanni Marchegiani, Stefano Andrianello, Giuseppe Malleo, Lucia De Gregorio, Aldo Scarpa, Mari Mino–Kenudson, Laura Maggino, Cristina R. Ferrone, Keith D. Lillemoe, Claudio Bassi, Carlos Fernández-del Castillo, Roberto Salvia,
To explore the role of pancreatic ductal adenocarcinoma (PDAC) size on surgical and survival outcomes.Tumor size is a prognostic factor for the majority of solid cancers, but the role for PDAC in predicting survival is not well delineated affecting the reliability of tumor node metastasis system classification.Between 1998 and 2012, 1507 patients with PDAC underwent resection at University of Verona Hospital and the Massachusetts General Hospital. All data were collected prospectively. Tumor size ...
Tópico(s): Cancer Genomics and Diagnostics
2016 - Lippincott Williams & Wilkins | Annals of Surgery
Settimio D’Andrea, A. V. Giordano, Sergio Carducci, Lucia Sacchetti, Stefano Necozione, M Costanzo, A de Gregorio, Alessandro Micillo, Felice Francavilla, Sandro Francavilla, Arcangelo Barbonetti,
Tópico(s): Urologic and reproductive health conditions
2015 - Springer Science+Business Media | Journal of Endocrinological Investigation
Daniele De Gregorio, Federico Tombari, Luigi Di Stefano,
We propose a complete system for 3D object reconstruction and grasping based on an articulated robotic manipulator. We deploy an RGB-D sensor as an end effector placed directly on the robotic arm, and process the acquired data to perform multi-view 3D reconstruction and object grasping. We leverage the high repeatability of the robotic arm to estimate 3D camera poses with millimeter accuracy and control each of the six sensor's DOF in a dexterous workspace. Thereby, we can estimate camera poses ...
Tópico(s): Soft Robotics and Applications
2016 - Springer Science+Business Media | Lecture notes in computer science