Raffaele Nardone, Cristina Florea, Yvonne Höller, Francesco Brigo, Viviana Versace, Piergiorgio Lochner, Stefan Golaszewski, Eugen Trinka,
In this narrative review we aimed to assess the usefulness of the different animal models in identifying injury mechanisms and developing therapies for humans suffering from spinal cord injury (SCI). Results obtained from rodent studies are useful but, due to the anatomical, molecular and functional differences, confirmation of these findings in large animals or non-human primates may lead to basic discoveries that cannot be made in rodent models and that are more useful for developing treatment ...
Tópico(s): Neurogenetic and Muscular Disorders Research
2017 - Elsevier BV | Zoology
Raffaele Nardone, Yvonne Höller, Patrick B. Langthaler, Piergiorgio Lochner, Stefan Golaszewski, Kerstin Schwenker, Francesco Brigo, Eugen Trinka,
Repetitive transcranial magnetic stimulation study. The analgesic effects of repetitive transcranial magnetic stimulation (rTMS) in chronic pain have been the focus of several studies. In particular, rTMS of the premotor cortex/dorsolateral prefrontal cortex (PMC/DLPFC) changes pain perception in healthy subjects and has analgesic effects in acute postoperative pain, as well as in fibromyalgia patients. However, its effect on neuropathic pain in patients with traumatic spinal cord injury (SCI) has ...
Tópico(s): Transcranial Magnetic Stimulation Studies
2016 - Springer Nature | Spinal Cord
Raffaele Nardone, Yvonne Höller, Francesco Brigo, V N Frey, Piergiorgio Lochner, Stefan Leis, SM Golaszewski, Eugen Trinka,
Topical review of the literature. The objective of this review article was to assess indications and usefulness of various neurophysiological techniques in diagnosis and management of cervical spondylogenic myelopathy (CSM). The MEDLINE, accessed by Pubmed and EMBASE electronic databases, was searched using the medical subject headings: 'compressive myelopathy', 'cervical spondylotic myelopathy (CSM)', 'cervical spondylogenic myelopathy', 'motor evoked potentials (MEPs)', 'transcranial magnetic stimulation', ' ...
Tópico(s): Intraoperative Neuromonitoring and Anesthetic Effects
2016 - Springer Nature | Spinal Cord
Wiebke Schlörmann, Marc Birringer, Alfred Lochner, Stefan Lorkowski, Inga Richter, Carsten Rohrer, Michael Glei,
Tópico(s): Metabolomics and Mass Spectrometry Studies
2015 - Springer Science+Business Media | European Journal of Nutrition
Raffaele Nardone, Yvonne Höller, Aljoscha Thomschewski, Alexander Kunz, Piergiorgio Lochner, Stefan Golaszewski, Eugen Trinka, Francesco Brigo,
Tópico(s): Parkinson's Disease Mechanisms and Treatments
2014 - Springer Science+Business Media | Journal of Neural Transmission
Raffaele Nardone, Yvonne Höller, Aljoscha Thomschewski, Peter Höller, Piergiorgio Lochner, Stefan Golaszewski, Francesco Brigo, Eugen Trinka,
Tópico(s): Ion channel regulation and function
2014 - Springer Science+Business Media | Journal of Neural Transmission
Piergiorgio Lochner, Stefan Golaszewski, Francesca Caleri, G. Ladurner, Frediano Tezzon, Giulio Zuccoli, Raffaele Nardone,
Tópico(s): Moyamoya disease diagnosis and treatment
2011 - Springer Science+Business Media | Neurological Sciences
Christian Berens, Susanne Lochner, Stefan Löber, Igor Usai, Andreas Schmidt, Lars Drueppel, Wolfgang Hillen, Peter Gmeiner,
We are in control. Rational-based structural modifications of tetracycline derivatives that can act as selective inducers of the transactivating proteins rtTA-1/2 and rtTA-D have been carried out. These modifications led to a novel two-stage regulatory system in which two separate genes can be regulated by using the selective inducers 9-dipropylaminodoxycycline (1) and doxycycline (dox). Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2268/ ...
Tópico(s): Cancer-related gene regulation
2006 - Wiley | ChemBioChem
Benjamin Lochner, Stefan Seth, Stefanie Wolter,
Tópico(s): Firm Innovation and Growth
2020 - Elsevier BV | Economics Letters
Raffaele Nardone, Viviana Versace, Yvonne Höller, Luca Sebastianelli, Francesco Brigo, Piergiorgio Lochner, Stefan Golaszewski, Leopold Saltuari, Eugen Trinka,
Transcranial magnetic stimulation (TMS) may represent a valuable tool for investigating important neurophysiological and pathophysiological aspects of myoclonus. Moreover, repetitive TMS (rTMS) can influence neural activity. In this review we performed a systematic search of all studies using TMS in order to explore cortical excitability/plasticity and rTMS for the treatment of myoclonus due to different aetiologies. We identified and reviewed 40 articles matching the inclusion criteria; 415 patients ...
Tópico(s): Glycogen Storage Diseases and Myoclonus
2018 - Elsevier BV | Brain Research Bulletin
Stefan Lochner, Caroline Dieckhöner,
The uprising and military confrontation in Libya that began in February 2011 has led to disruptions of gas supplies to Europe. An analysis of how Europe has compensated for these missing gas volumes shows that this situation has not affected security of supply. However, this situation would change if the North African uprising were to spread to Algeria. Since Algeria is a much more important gas supplier to Europe than is Libya, more severe consequences would be likely. Applying a natural gas infrastructure ...
Tópico(s): Market Dynamics and Volatility
2012 - Elsevier BV | Energy Policy
Hanna Wang‐Helmreich, Stefan Lochner,
Greenhouse gas emission reductions are at the centre of national and international efforts to mitigate climate change. In road transportation, many politically incentivised measures focus on increasing the energy efficiency of established technologies, or promoting electric or hybrid vehicles. The abatement potential of the former approach is limited, electric mobility technologies are not yet market-ready. In a case study for Germany, this paper focuses on natural gas powered vehicles as a bridging ...
Tópico(s): Energy, Environment, and Transportation Policies
2012 - Vinča Institute of Nuclear Sciences | Thermal Science
Caroline Dieckhöner, Stefan Lochner, Dietmar Lindenberger,
► Application of a highly resoluted natural gas infrastructure and dispatch model. ► Analysis of integration of the European natural gas market in 2019. ► Simulation of gas flows in Europe for different infrastructure scenarios. ► Identification of location-specific marginal supply costs and congestions in gas network. ► Integrated gas market but bottleneck between Germany and Denmark and in Eastern Europe. Increasing European natural gas import dependency and risks of natural gas supply disruptions support the need ...
Tópico(s): Integrated Energy Systems Optimization
2012 - Elsevier BV | Applied Energy
Rising import dependency, increasing market liberalization and cross-border trade and security of supply fears facilitate investments in natural gas supply infrastructures in Europe. In order to ensure an efficient allocation of capital resources, it is important to identify congestion in the existing system and investment requirements based on economic principles. This paper first outlines an analytical framework for the identification of bottlenecks and the evaluation of transport capacities and ...
Tópico(s): Electric Power System Optimization
2011 - Elsevier BV | Energy
Tópico(s): Natural Resources and Economic Development
2011 - Elsevier BV | Journal of Natural Gas Science and Engineering
Martin Lienert, Stefan Lochner,
The analysis of complex electricity generation systems such as the European one require large scale models based on extensive databases of the relevant infrastructures. Such models are increasingly used to assist policymaking by developing scenarios to investigate the impact of certain policies on generation capacities, investments and prices. The continuing liberalization and interconnection of energy markets thereby requires the considerations of multiple interdependencies with other markets. ...
Tópico(s): Smart Grid Energy Management
2011 - Elsevier BV | International Journal of Electrical Power & Energy Systems
Quickly declining natural gas reserves in some parts of the world, increasing demand in today's major gas consuming regions, the emergence of new demand centres and the globalization of natural gas markets caused by the rising importance of liquefied natural gas (LNG) are changing global gas supply structures and will continue to do so over the next decades. Applying a global gas market model, we produce a forecast for global gas supply to 2030 and determine the supplier-specific long-run average ...
Tópico(s): Renewable energy and sustainable power systems
2009 - Elsevier BV | Energy Policy
Patrick Haider, Pascal Freko, Stefan Lochner, Thomas Reiter, Sebastian Rehfeldt, Harald Klein,
Within the Kopernikus project "SynErgie", the sub-project "FlexASU" investigates an enhancement of the load flexibility of air separation units with the goal of synchronizing their power consumption with the availability of renewable energy sources. The main heat exchanger of these plants was identified as a key component for a dynamic plant operation, because startup, shutdown and load-change procedures can lead to thermal stress and an increased lifetime consumption of the apparatus. Aluminum-brazed ...
Tópico(s): Spacecraft and Cryogenic Technologies
2019 - Elsevier BV | Process Safety and Environmental Protection
Tópico(s): Renewable Energy and Sustainability
2008 - Springer Science+Business Media | Zeitschrift für Energiewirtschaft
Agnieszka Sendek, Canan Karakoç, Cameron Wagg, Jara Domínguez‐Begines, G.M. Couto, Marcel G. A. van der Heijden, Ali Ahmad Naz, Alfred Lochner, Antonis Chatzinotas, Stefan Klotz, Lorena Gómez‐Aparicio, Nico Eisenhauer,
Droughts associated with climate change alter ecosystem functions, especially in systems characterized by low biodiversity, such as agricultural fields. Management strategies aimed at buffering climate change effects include the enhancement of intraspecific crop diversity as well as the diversity of beneficial interactions with soil biota, such as arbuscular mycorrhizal fungi (AMF). However, little is known about reciprocal relations of crop and AMF diversity under drought conditions. To explore ...
Tópico(s): Ecology and Vegetation Dynamics Studies
2019 - Nature Portfolio | Scientific Reports
Raffaele Nardone, Luca Sebastianelli, Viviana Versace, Leopold Saltuari, Piergiorgio Lochner, Vanessa Frey, Stefan Golaszewski, Francesco Brigo, Eugen Trinka, Yvonne Höller,
The clinical distinction of frontotemporal dementia (FTD) and Alzheimer’s disease (AD) may be difficult. In this narrative review we summarize and discuss the most relevant electroencephalography (EEG) studies which have been applied to demented patients with the aim of distinguishing the various types of cognitive impairment. EEG studies revealed that patients at an early stage of FTD or AD displayed different patterns in the cortical localization of oscillatory activity across different frequency ...
Tópico(s): Neural dynamics and brain function
2018 - Hindawi Publishing Corporation | Disease Markers
Raffaele Nardone, Yvonne Höller, Alexandra Taylor, Piergiorgio Lochner, Frediano Tezzon, Stefan Golaszewski, Francesco Brigo, Eugen Trinka,
Canine degenerative myelopathy (CDM) represents a unique naturally occurring animal model for human amyotrophic lateral sclerosis (ALS) because of similar clinical signs, neuropathologic findings, and involvement of the superoxide dismutase 1 (SOD1) mutation. A definitive diagnosis can only be made postmortem through microscopic detection of axonal degeneration, demyelination and astroglial proliferation, which is more severe in the dorsal columns of the thoracic spinal cord and in the dorsal portion ...
Tópico(s): Neurological diseases and metabolism
2015 - Elsevier BV | Zoology
Raffaele Nardone, Jürgen Bergmann, Monica Christova, Piergiorgio Lochner, Frediano Tezzon, Stefan Golaszewski, Eugen Trinka, Francesco Brigo,
Acute and chronic consumption of alcohol have direct effects on central nervous system by altering predominantly gamma-aminobutyric acidergic and glutamatergic neurotransmission. Abnormalities in these neurotransmitter systems can be demonstrated by changes in cortical excitability parameters assessed with transcranial magnetic stimulation (TMS). Furthermore, integrated approaches utilizing TMS combined with electroencephalography (EEG) enable the evaluation of the focal effects of alcohol on the ...
Tópico(s): Neurological disorders and treatments
2012 - Elsevier BV | Neuroscience Research
Orlando Guntinas‐Lichius, Thomas Wendt, Jens Buentzel, Dirk Eßer, Peter Lochner, Andreas Mueller, Stefan Schultze‐Mosgau, A. Altendorf-Hofmann,
Tópico(s): Salivary Gland Tumors Diagnosis and Treatment
2009 - Springer Science+Business Media | Journal of Cancer Research and Clinical Oncology
Christine Löchner, Jean‐Paul Fouché, Stéfan du Plessis, Bruce Spottiswoode, Soraya Seedat, Naomi Fineberg, Samuel R. Chamberlain, Dan J. Stein,
There is evidence to suggest that obsessive-compulsive disorder (OCD) is associated with structural abnormalities in cortico-striato-thalamic circuits, yet the extent of white matter abnormalities is not well established. In this study, we used diffusion tensor imaging (DTI) to examine white matter integrity in specific regions of interest (ROIs) in patients with OCD.Patients with OCD and sex-, age- and IQ-matched healthy controls underwent DTI. The primary objective was to explore whether patients ...
Tópico(s): Botulinum Toxin and Related Neurological Disorders
2012 - Canadian Medical Association | Journal of Psychiatry and Neuroscience
Raffaele Nardone, Jürgen Bergmann, Martin Kronbichler, Francesca Caleri, Piergiorgio Lochner, Frediano Tezzon, G. Ladurner, Stefan Golaszewski,
Alcohol addiction is a complex brain disease caused by alterations in crucial neurotransmitter systems, including gamma-aminobutyric acid (GABA) and glutamate. These disturbances could be revealed by changes in cortical excitability parameters, as assessed by transcranial magnetic stimulation (TMS). This study was aimed to further investigate the complex pathophysiology of alcohol withdrawal syndrome (AWS).Motor cortex excitability was examined in 13 subjects with AWS in a mild predelirial state, in ...
Tópico(s): Electroconvulsive Therapy Studies
2010 - Wiley | Alcoholism Clinical and Experimental Research
Tobias Bucher, Aleksandr Vaskin, Rajeshkumar Mupparapu, Franz J. F. Löchner, Antony George, Katie E. Chong, Stefan Fasold, Christof Neumann, Duk‐Yong Choi, Falk Eilenberger, Frank Setzpfandt, Yuri S. Kivshar, Thomas Pertsch, Andrey Turchanin, Isabelle Staude,
We experimentally investigate coupling of the photoluminescence (PL) from monolayers of MoS2 to Mie-resonant metasurfaces consisting of silicon nanocylinders. By a systematic variation of the nanocylinder diameter, we sweep the metasurface resonances over the excitonic emission band of monolayer MoS2. We observe strong enhancement, as well as spectral and directional reshaping of the emission. By a comprehensive optical characterization, we unveil the different physical factors, including electronic, ...
Tópico(s): Metamaterials and Metasurfaces Applications
2019 - American Chemical Society | ACS Photonics
Lucia Sinka, Laura Abraira, Lukas L. Imbach, Dominik Zieglgänsberger, Estevo Santamarina, José Álvarez‐Sabín, Carolina Ferreira‐Atuesta, M.B. Katan, Natalie Scherrer, Giulio Bicciato, Robert Terziev, Cyril Simmen, K Schubert, Adham Elshahabi, Christian R. Baumann, Nico Döhler, Barbara Erdélyi‐Canavese, Ansgar Felbecker, Philip Siebel, Michael Winklehner, Tim J. von Oertzen, Judith Wagner, Gian Luigi Gigli, Anna Serafini, Annacarmen Nilo, Francesco Janes, Giovanni Merlino, Mariarosaria Valente, María Paula Zafra-Sierra, Hernán Bayona, Julian Conrad, Stefan Evers, Piergiorgio Lochner, Frauke Roell, Francesco Brigo, Carla Bentes, Ana Rita Peralta, Teresa Pinho e Melo, Mark R. Keezer, John S. Duncan, Josemir W. Sander, Barbara Tettenborn, Matthias J. Koepp, Marian Galovic,
Importance Acute symptomatic seizures occurring within 7 days after ischemic stroke may be associated with an increased mortality and risk of epilepsy. It is unknown whether the type of acute symptomatic seizure influences this risk. Objective To compare mortality and risk of epilepsy following different types of acute symptomatic seizures. Design, Setting, and Participants This cohort study analyzed data acquired from 2002 to 2019 from 9 tertiary referral centers. The derivation cohort included ...
Tópico(s): Pharmacological Effects and Toxicity Studies
2023 - American Medical Association | JAMA Neurology
Carolina Ferreira‐Atuesta, Nico Döhler, Barbara Erdélyi‐Canavese, Ansgar Felbecker, Philip Siebel, Natalie Scherrer, Giulio Bicciato, Juliane Schweizer, Lucia Sinka, Lukas L. Imbach, M.B. Katan, Laura Abraira, Estevo Santamarina, José Álvarez‐Sabín, Michael Winklehner, Tim J. von Oertzen, Judith Wagner, Gian Luigi Gigli, Anna Serafini, Francesco Janes, Giovanni Merlino, Mariarosaria Valente, Giorgia Gregoraci, Julian Conrad, Stefan Evers, Piergiorgio Lochner, Frauke Roell, Francesco Brigo, Carla Bentes, Ana Rita Peralta, Teresa Pinho e Melo, Mark R. Keezer, John S. Duncan, Josemir W. Sander, Barbara Tettenborn, Matthias J. Koepp, Marian Galovic,
Objective The purpose of this study was to identify risk factors for acute symptomatic seizures and post‐stroke epilepsy after acute ischemic stroke and evaluate the effects of reperfusion treatment. Methods We assessed the risk factors for post‐stroke seizures using logistic or Cox regression in a multicenter study, including adults from 8 European referral centers with neuroimaging‐confirmed ischemic stroke. We compared the risk of post‐stroke seizures between participants with or without reperfusion ...
Tópico(s): Neonatal and fetal brain pathology
2021 - Wiley | Annals of Neurology
Larissa Hauer, Giuditta Ilaria Scarano, Francesco Brigo, Stefan Golaszewski, Piergiorgio Lochner, Eugen Trinka, Johann Sellner, Raffaele Nardone,
We performed a systematic review of the studies employing repetitive transcranial magnetic stimulation (rTMS) in subjects with smoking addiction. High-frequency (HF) rTMS over the prefrontal cortex (PFC), in particular the left dorsolateral PFC (DLPFC), might represent a save and innovative treatment tool for tobacco consumption and craving in nicotine-dependent otherwise healthy people. rTMS can be effective for this indication also in patients with schizophrenia, but the results are conflicting and ...
Tópico(s): Functional Brain Connectivity Studies
2019 - Elsevier BV | Psychiatry Research