Tobias Goschzik, Martin Mynarek, Evelyn Doerner, Alina Schenk, Isabel Spier, Monika Warmuth‐Metz, Brigitte Bison, Denise Obrecht, Nina Struve, Rolf‐Dieter Kortmann, Matthias Schmid, Stefan Aretz, Stefan Rutkowski, Torsten Pietsch,
This study aimed to re-evaluate the prognostic impact of TP53 mutations and to identify specific chromosomal aberrations as possible prognostic markers in WNT-activated medulloblastoma (WNT-MB). In a cohort of 191 patients with WNT-MBs, mutations in CTNNB1, APC, and TP53 were analyzed by DNA sequencing. Chromosomal copy-number aberrations were assessed by molecular inversion probe technology (MIP), SNP6, or 850k methylation array hybridization. Prognostic impact was evaluated in 120 patients with ...
Tópico(s): Chromatin Remodeling and Cancer
2022 - Springer Science+Business Media | Acta Neuropathologica
Thomas Kapapa, Stefan Röhrer, Sabine Struve, Matthias Petscher, Ralph König, Christian Rainer Wirtz, Dieter Woischneck,
Introduction . The secondary increase in the size of intracranial haematomas as a result of spontaneous haemorrhage or trauma is of particular relevance in the event of prior intake of platelet aggregation inhibitors. We describe the effect of desmopressin acetate as a means of temporarily stabilising the platelet function. Patients and Methods . The platelet function was analysed in 10 patients who had received single ( N = 4 ) or multiple ( N = 6 ) doses of acetylsalicylic acid and 3 patients (control group) who ...
Tópico(s): Spinal Hematomas and Complications
2014 - Hindawi Publishing Corporation | Neurology Research International
Jens Schneider, M Struve, Ulf Trommler, Michael Schlüter, Lisa Seidel, Sebastian Dietrich, Stefan Rönsch,
A sustainable way to produce plastics made from biomass (biomass to gas) and electricity (power to gas) could be obtained by the direct synthesis of light alkenes. Samples (≤ 1 g) of the bulk catalysts Co/Fe, Fe/Na/S and the supported catalysts Fe/Mn | MgO and Co | SiO2 are mentioned in the literature to allow the direct synthesis of light alkenes. These materials are studied in extended fixed beds with catalyst amounts between 35 and 70 g and classic syngas (H2 and CO) in this work in order to prepare a ...
Tópico(s): Catalysis and Oxidation Reactions
2017 - Elsevier BV | Fuel Processing Technology
Mahmoud Diab, Marcus Franz, Stefan Hagel, Albrecht Güenther, Antonio Struve, Rita Musleh, Anika Penzel, Christoph Sponholz, Thomas Lehmann, Henning Kuehn, Karim Ibrahim, Marcus Jahnecke, Holger H. Sigusch, Henning Ebelt, Gloria Faerber, Otto W. Witte, Bettina Loeffler, Michael Bauer, Mathias W. Pletz, P. Christian Schulze, Torsten Doenst,
Infective endocarditis (IE) requires multidisciplinary management. We established an endocarditis team within our hospital in 2011 and a state-wide endocarditis network with referring hospitals in 2015. We aimed to investigate their impact on perioperative outcomes.We retrospectively analyzed data from patients operated on for IE in our center between 01/2007 and 03/2018. To investigate the impact of the endocarditis network on referral latency and pre-operative complications we divided patients ...
Tópico(s): Antimicrobial Resistance in Staphylococcus
2021 - Multidisciplinary Digital Publishing Institute | Journal of Clinical Medicine
Martin S. Bojer, Anette M. Hammerum, Steffen Jørgensen, Frank Hansen, Stefan S. Olsen, Karen A. Krogfelt, Carsten Struve,
A plasmid‐encoded ClpK protein was recently identified as a predictor of a heat‐resistant phenotype in the opportunistic pathogen K lebsiella pneumoniae . This study was undertaken to evaluate the presence of the clpK gene in extended‐spectrum β‐lactamase ( ESBL )‐producing K . pneumoniae and to assess the probable co‐transfer of multi‐resistance with the heat resistance phenotype. A D anish collection of 80 ESBL ‐producing K . pneumoniae bloodstream infection isolates was screened for clpK by colony hybridization. ...
Tópico(s): Enterobacteriaceae and Cronobacter Research
2012 - Wiley | Apmis
... presently doing research in collaboration with Professor Wolfgang Struve (from the University of Freiburg) on Friedrich Heinrich Jacobi's critique of German Idealism.Search for more papers by this author Wilhelm Stefan Wurzer, Wilhelm Stefan Wurzer Milwaukee, Wisconsin Wilhelm Stefan Wurzer received his Ph.D. from the University of Freiburg, West Germany. He has done extensive research on Friedrich Nietzsche in the Nietzsche-Archive at Weimar and is the author of Nietzsche und Spinoza which is to appear in the Monographien zur Philosophischen Forschung published by Anton Hain (Meisenheim/Glan, 1975). He is presently doing research in collaboration with Professor Wolfgang Struve (from the University of Freiburg) on Friedrich Heinrich ...
1975 - Wiley | The Southern Journal of Philosophy
Sergei Savikhin, Herbert van Amerongen, Stefan L.S. Kwa, Rienk van Grondelle, Walter S. Struve,
Temperature dependence in electronic energy transfer steps within light-harvesting antenna trimers from photosystem II was investigated by studying Chl a pump-probe anisotropy decays at several wavelengths from 675 to 682 nm. The anisotropy lifetime is markedly sensitive to temperature at the longest wavelengths (680-682 nm), increasing by factors of 5 to 6 as the trimers are cooled from room temperature to 13 K. The temperature dependence is muted at 677 and 675 nm. This behavior is modeled using ...
Tópico(s): Spectroscopy and Quantum Chemical Studies
1994 - Elsevier BV | Biophysical Journal
Produção Nacional
Revisado por pares
Anna‐Lena Volckmar, Chung‐Ting Han, Carolin Pütter, Stefan A. Haas, Carla Ivane Ganz Vogel, Nadja Knoll, Christoph Struve, Maria Göbel, Katharina Haas, Nikolas Herrfurth, Ivonne Jarick, Harald Grallert, Annette Schürmann, Hadi Al‐Hasani, Johannes Hebebrand, Sascha Sauer, Anke Hinney,
Introduction Genes involved in body weight regulation that were previously investigated in genome-wide association studies (GWAS) and in animal models were target-enriched followed by massive parallel next generation sequencing. Methods We enriched and re-sequenced continuous genomic regions comprising FTO, MC4R, TMEM18, SDCCAG8, TKNS, MSRA and TBC1D1 in a screening sample of 196 extremely obese children and adolescents with age and sex specific body mass index (BMI) ≥ 99th percentile and 176 lean adults ( ...
Tópico(s): Epigenetics and DNA Methylation
2016 - Public Library of Science | PLoS ONE
Tópico(s): Medical and Health Sciences Research
1998 - Springer Nature | Senckenbergiana lethaea
Stefan L.S. Kwa, F GROENEVELD, Jan P. Dekker, R VANGRONDELLE, H VANAMERONGEN, S LIN, W STRUVE,
Tópico(s): Light effects on plants
1992 - Elsevier BV | Biochimica et Biophysica Acta (BBA) - Bioenergetics
Stefan L.S. Kwa, Herbert van Amerongen, Su Lin, Jan P. Dekker, Rienk van Grondelle, Walter S. Struve,
Time-resolved absorption difference profiles were obtained for LHC-II trimers, isolated from Photosystem II in spinach with n-dodecyl β-d-maltoside, using one-color and two-color pump-probe techniques. The one-color isotropic signals are predominantly excited state absorption at 640 nm, and a combination of photobleaching and stimulated emission at wavelengths ≥ 665nm. At intermediate wavelengths, dynamic red-shifting due to downhill energy transfer among the chlorophyll (Chl) spectral forms produces ...
Tópico(s): Light effects on plants
1992 - Elsevier BV | Biochimica et Biophysica Acta (BBA) - Bioenergetics
Journal Article Method for Evaluation of Zeros of Bessel Functions Get access J. GARD, J. GARD J. Stefan Institute, Institute of Mathematics, Physics and Mechanics, University of LjubljanaLjubljana, Yugoslavia Search for other works by this author on: Oxford Academic Google Scholar E. ZAKRAJŜEK E. ZAKRAJŜEK J. Stefan Institute, Institute of Mathematics, Physics and Mechanics, University of LjubljanaLjubljana, Yugoslavia Search for other works by this author on: Oxford Academic Google Scholar IMA ...
Tópico(s): Advanced Mathematical Identities
1973 - Oxford University Press | IMA Journal of Applied Mathematics
Stefan L.S. Kwa, F.G. Groeneveld, Jan P. Dekker, Rienk van Grondelle, Herbert van Amerongen, S.H. Lin, Walter S. Struve,
Abstract The major chlorophyll a/b light-harvesting complex from spinach thylakoid membranes was analyzed by steady-state polarized light spectroscopy at 4 K and by one-color and two-color pump-probe spectroscopy at room temperature. Steady-state absorption, linear dichroism and circular dichroism spectra indicate that the Chl Q y (0−0) absorption region is characterized by at least six transitions with significant differences in absorption, orientation and rotational strength. Steady-state low-temperature ...
Tópico(s): Photoreceptor and optogenetics research
1992 - Elsevier BV | Biochimica et Biophysica Acta (BBA) - Bioenergetics
Stefan Nickel, Winfried Schröder, Uwe Drehwald, Annekatrin Dreyer, Markus Preußing, Norbert J. Stapper, Stefan Struve, Dietmar Teuber, Barbara Völksen,
Development of heavy metals and nitrogen concentrations in moss throughout Germany Under the Convention on Long-range Transboundary Air Pollution, moss samples have been collected in Europe every five years since 1990 and evaluated for the concentration of heavy metals (since 1990) and nitrogen (since 2005). This article uses the data of this European Moss Survey to geostatistically evaluate and map the spatial distribution and temporal development of the heavy metals cadmium (Cd), lead (Pb) and mercury ( ...
Tópico(s): Bryophyte Studies and Records
2018 - Swiss Forestry Society | Schweizerische Zeitschrift fur Forstwesen
Stefan L.S. Kwa, Herbert van Amerongen, Lin Su, Jan P. Dekker, Rienk van Grondelle, Walter S. Struve,
Tópico(s): Light effects on plants
1992 - Elsevier BV | Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
Stefan Schneider, Stefanie Brassen, Uli Bromberg, Tobias Banaschewski, Patricia Conrod, Herta Flor, Juergen Gallinat, Hugh Garavan, Andreas Heinz, J. L. Martinot, Frauke Nees, Marcella Rietschel, Michael N. Smolka, Andreas Ströhle, Maren Struve, Gunter Schumann, Christian Büchel,
Considerable animal and human research has been dedicated to the effects of parenting on structural brain development, focusing on hippocampal and prefrontal areas. Conversely, although functional imaging studies suggest that the neural reward circuitry is involved in parental affection, little is known about mothers' interpersonal qualities in relation to their children's brain structure and function. Moreover, gender differences concerning the effect of maternal qualities have rarely been investigated ...
Tópico(s): Stress Responses and Cortisol
2012 - Springer Nature | Translational Psychiatry
Stefan Schütze, Thomas Machleidt, Dieter Adam, Ralf Schwandner, Katja Wiegmann, Marie‐Luise Kruse, Michael Heinrich, Marc Wickel, Martin Krönke,
... FAN (21Adam-Klages S. Adam D. Wiegmann K. Struve S. Kolanus W. Schneider-Mergener J. Krönke M. ... SMase) (21Adam-Klages S. Adam D. Wiegmann K. Struve S. Kolanus W. Schneider-Mergener J. Krönke M. ... FAN (21Adam-Klages S. Adam D. Wiegmann K. Struve S. Kolanus W. Schneider-Mergener J. Krönke M. ... SMase) (21Adam-Klages S. Adam D. Wiegmann K. Struve S. Kolanus W. Schneider-Mergener J. Krönke M. ...
Tópico(s): Immune Response and Inflammation
1999 - Elsevier BV | Journal of Biological Chemistry
Shweta Godbole, Hannah Voß, Antonia Gocke, Simon Schlumbohm, Yannis Schumann, Bojia Peng, Martin Mynarek, Stefan Rutkowski, Matthias Dottermusch, Mario M. Dorostkar, Andrey Korshunov, Thomas Mair, Stefan M. Pfister, Marcel Kwiatkowski, Madlen Hotze, Philipp Neumann, Christian Hartmann, Joachim Weis, Friederike Liesche‐Starnecker, Yudong Guan, Manuela Moritz, Bente Siebels, Nina Struve, Hartmut Schlüter, Ulrich Schüller, Christoph Krisp, Julia E. Neumann,
Abstract Medulloblastomas (MBs) are malignant pediatric brain tumors that are molecularly and clinically heterogenous. The application of omics technologies—mainly studying nucleic acids—has significantly improved MB classification and stratification, but treatment options are still unsatisfactory. The proteome and their N-glycans hold the potential to discover clinically relevant phenotypes and targetable pathways. We compile a harmonized proteome dataset of 167 MBs and integrate findings with DNA ...
Tópico(s): Epigenetics and DNA Methylation
2024 - Nature Portfolio | Nature Communications
Lukas Wägner, Brigitte Bison, Anne Neumann‐Holbeck, T. Tischler, Anika Guiard, Denise Obrecht, Holger Ottensmeier, Rolf‐Dieter Kortmann, Katja von Hoff, Paul‐Gerhardt Schlegel, Marc Remke, Antje Redlich, Ursula Holzer, Claudia Blattmann, Gudrun Fleischhack, Annette Sander, Norbert Jorch, Martina Becker, Michael Karremann, Michael C. Frühwald, Miriam van Buiren, Nina Struve, Monika Warmuth‐Metz, Stefan Rutkowski, Martin Mynarek,
Abstract OBJECTIVES: Leukoencephalopathy (LEP, i.e. white matter T2-/FLAIR-hyperintensities on MRI) and impaired neuropsychological outcome are side effects of multimodal therapy of medulloblastoma. We identified risk factors for LEP and correlated LEP with neurocognitive functioning. PATIENTS AND METHODS: Severity of LEP either at the end of therapy (n=118), two years (n=126), or five years after surgery (n=139) was evaluated according to an adapted Fazekas classification for 162 survivors of medulloblastoma ( ...
Tópico(s): Cancer-related cognitive impairment studies
2022 - Oxford University Press | Neuro-Oncology
Tobias Goschzik, Martin Mynarek, Evelyn Doerner, Isabel Spier, Monika Warmuth‐Metz, Brigitte Bison, Denise Obrecht, Nina Struve, RD Kortmann, Peter Hau, Stefan Aretz, Stefan Rutkowski, Torsten Pietsch,
Abstract Background This genetic analysis of WNT-activated medulloblastomas (WNT-MBs) aimed to re-evaluate the prognostic impact of age, TP53 mutations and to identify specific chromosomal aberrations as possible prognostic markers. Material and Methods In a cohort of 191 patients with WNT-MBs, mutations in CTNNB1, APC and TP53 were analyzed by Sanger and/or NGS panel sequencing. Chromosomal copy number aberrations were assessed by high-resolution, genome-wide molecular inversion probe technology ( ...
Tópico(s): Cancer-related Molecular Pathways
2022 - Oxford University Press | Neuro-Oncology
Christoph Bennenhei, Hangyong Shan, Marti Struve, Nils Kunte, Falk Eilenberger, Jürgen Ohmer, Utz Fischer, Stefan Schumacher, Xuekai Ma, Christian Schneider, Martin Esmann,
Organic molecule exciton-polaritons in photonic lattices are a versatile platform to emulate unconventional phases of matter at ambient temperatures, including protected interface modes in topological insulators. Here, we investigate bosonic condensation in the most prototypical higher-order topological lattice: a 2D-version of the Su–Schrieffer–Heeger model. Under strong optical pumping, we observe bosonic condensation into both 0D and 1D topologically protected modes. The resulting 1D macroscopic ...
Tópico(s): Topological Materials and Phenomena
2024 - American Chemical Society | ACS Photonics
Gerhart Jander, Karl Friedrich Jahr, Wilhelm Heukeshoven,
... l.c., S. 386. p387_4) Svanberg u. Struve, Journ. prakt. Chem. 44 (1848), 257. p387_5) ... Fick, Pogg. Ann. 94 (1865), 59. p392_1) Stefan, Ber. d. Kais. Akadem. zu Wien, Mathem.-naturw. ...
Tópico(s): Lanthanide and Transition Metal Complexes
1930 - Wiley | Zeitschrift für anorganische und allgemeine Chemie
Stefan Schneider, Judith Peters, Uli Bromberg, Stefanie Brassen, Mareike M. Menz, Stephan F. Miedl, Eva Loth, Tobias Banaschewski, Alexis Barbot, Gareth J. Barker, Patricia Conrod, Jeff Dalley, Herta Flor, Juergen Gallinat, Hugh Garavan, Andreas Heinz, Bernd Itterman, Catherine Mallik, K Mann, Éric Artiges, Tomáš Paus, J.-B. Poline, Marcella Rietschel, L. Reed, Michael N. Smolka, Rainer Spanagel, Claudia Speiser, Andreas Ströhle, Maren Struve, G Schumann, Christian Büchel,
Previous studies have observed a sex-dependent lateralization of amygdala activation related to emotional memory. Specifically, it was shown that the activity of the right amygdala correlates significantly stronger with memory for images judged as arousing in men than in women, and that there is a significantly stronger relationship in women than in men between activity of the left amygdala and memory for arousing images. Using a large sample of 235 male adolescents and 235 females matched for age ...
Tópico(s): Evolutionary Psychology and Human Behavior
2011 - Elsevier BV | NeuroImage
Melanie Schoof, Shweta Godbole, Thomas Albert, Matthias Dottermusch, Carolin Walter, Annika Ballast, Nan Qin, M. Olivera, Carolin Göbel, Sina Neyazi, Dörthe Holdhof, Catena Kresbach, L. Molloy Peter, Gefion Dorothea Epplen, Vanessa Thaden, Michael Spohn, Mirjam Blattner-Johnson, Franziska Modemann, Martin Mynarek, Stefan Rutkowski, Martin Sill, Julian Varghese, Ann‐Kristin Afflerbach, Alicia Eckhardt, Daniel Münter, Archana Verma, Nina Struve, David Jones, Marc Remke, Julia E. Neumann, Kornelius Kerl, Ulrich Schüller,
Pediatric high-grade gliomas of the subclass MYCN (HGG-MYCN) are highly aggressive tumors frequently carrying MYCN amplifications, TP53 mutations, or both alterations. Due to their rarity, such tumors have only recently been identified as a distinct entity, and biological as well as clinical characteristics have not been addressed specifically. To gain insights into tumorigenesis and molecular profiles of these tumors, and to ultimately suggest alternative treatment options, we generated a genetically ...
Tópico(s): Sarcoma Diagnosis and Treatment
2023 - Nature Portfolio | Nature Communications
Svenja Tonn, Andrey Korshunov, Denise Obrecht, Martin Sill, Michael Spohn, Katja von Hoff, Till Milde, Torsten Pietsch, Tobias Goschzik, Brigitte Bison, Björn-Ole Juhnke, Nina Struve, Dominik Sturm, Felix Sahm, Michael Bockmayr, Carsten Friedrich, André O. von Bueren, Nicolas U. Gerber, Martin Benesch, David Jones, Marcel Kool, Annika K. Wefers, Ulrich Schüller, Stefan M. Pfister, Stefan Rutkowski, Martin Mynarek,
Abstract Background The prognostic impact of clinical risk factors and DNA methylation patterns in sonic hedgehog (SHH)-activated early childhood desmoplastic/nodular medulloblastoma (DMB) or medulloblastoma with extensive nodularity (MBEN) were evaluated to better identify patients at risk for relapse. Methods One hundred and forty-four patients with DMB (n = 99) or MBEN (n = 45) aged <5 years and treated with radiation-sparing approaches, including intraventricular methotrexate in 132 patients were evaluated. ...
Tópico(s): Fetal and Pediatric Neurological Disorders
2023 - Oxford University Press | Neuro-Oncology
Mahmoud Diab, Marcus Franz, Stefan Hagel, A. Guenther, Antonio Struve, Henning Kuehn, Karim Ibrahim, Marcus Jahnecke, Holger H. Sigusch, Henning Ebelt, Gloria Faerber, Thomas Lehmann, P. Christian Schulze, Mathias W. Pletz, Torsten Doenst,
Abstract Background Infective endocarditis (IE) requires a high degree of suspicion and advanced level of multidisciplinary management. In 2015, the European guidelines recommended the formation of an endocarditis-team (ET) for optimal treatment of IE. In 2011, we already established an ET within the hospital that was only consulted on demand for certain patients. Since 2015, ET has been increasingly involved in the management of almost all patients with IE. In addition, we established in 2015 a statewide ...
Tópico(s): Actinomycetales infections and treatment
2021 - Oxford University Press | European Heart Journal
... names to mention here are Sergey Bulgakov, Peter Struve, Mihail Tugan-Baranovsky, Joseph Kulisher, Nikolay Berdiyaev, Semyon ... Demostenov and Ivan Kinkel had both Russian (Peter Struve was their mentor) as well as Western education: ... Kinkel's teacher, the great Russian economist Peter Struve, is revealing. Struve asserts that “a systematician–economist examines the history ... help of the systematic categories of political economy” (Struve Citation1913, p. 35). Thus, there are two ways ... first we could call “theoretical economic history” (Kinkel, Struve, Sombart and others) and the second – “historical economic ...
Tópico(s): Culture, Economy, and Development Studies
2013 - Taylor & Francis | European Journal of the History of Economic Thought
Simon Feyerabend, Thorsten Rieckmann, Britta Riepen, Agnes Oetting, Sabrina Christiansen, Melanie Schoof, Annika Hardt, Sabrina Köcher, Julia E. Neumann, Rudolf Schwarz, Norman Mack, Benjamin Schwalm, Aniello Federico, Till Milde, Marcel Kool, Ulrich Schüller, Stefan Rutkowski, Cordula Petersen, Kai Rothkamm, Martin Mynarek, Nina Struve,
Abstract Medulloblastoma (WHO grade 4) is the most common malignant brain tumor of childhood. Despite the high importance of radiotherapy for disease control, the mechanisms underlying response and resistance to radiotherapy are incompletely understood. Therefore, we assessed the radiosensitivity and DNA repair capacity of medulloblastoma cell lines in-vitro and of patient-derived xenograft (PDX) models ex-vivo. Cell survival after irradiation of seven medulloblastoma cell lines displaying different ...
Tópico(s): Molecular Biology Techniques and Applications
2022 - Oxford University Press | Neuro-Oncology
Svenja Tonn, Denise Obrecht, Martin Sill, Michael Spohn, Till Milde, Torsten Pietsch, Brigitte Bison, Björn-Ole Juhnke, Nina Struve, Carsten Friedrich, André O. von Bueren, Nicolas U. Gerber, Martin Benesch, Natalie Jäger, Marcel Kool, Andrey Korshunov, Ulrich Schüller, Stefan M. Pfister, Stefan Rutkowski, Martin Mynarek,
Abstract PURPOSE/METHODS: Clinical and molecular risk factors in 142 patients <5 years with desmoplastic medulloblastoma (DMB) or medulloblastoma with extensive nodularity (MBEN) were investigated. Patients were diagnosed between 1992 and 2020 and treated with radiation-sparing approaches, 131 with intraventricular methotrexate. 14 patients with metastatic disease received high-dose chemotherapy. DNA methylation profiles of 77 sonic hedgehog (SHH)-activated medulloblastoma were reclassified according ...
Tópico(s): Hedgehog Signaling Pathway Studies
2022 - Oxford University Press | Neuro-Oncology
The recursion relation for where is the McDonald function, is extended to the case of together with the same for the Bessel functions of the first and second kind. An application to the Bessel-type kernels is indicated which is of importance for inversion problems for the Riesz potential operator.
Tópico(s): Quantum Mechanics and Non-Hermitian Physics
2001 - Taylor & Francis | Integral Transforms and Special Functions