Mohsen Ghanbari, Shashini T. Munshi, Buyun Ma, Bas Lendemeijer, Sakshi Bansal, Hieab H.H. Adams, Wenshi Wang, Kerstin Goth, Denise E. Slump, Mirjam C. G. N. van den Hout, Wilfred F. J. van IJcken, Savério Bellusci, Qiuwei Pan, Stefan J. Erkeland, Femke M.S. de Vrij, Steven A. Kushner, M. Arfan Ikram,
Noncoding RNAs have been widely recognized as essential mediators of gene regulation. However, in contrast to protein-coding genes, much less is known about the influence of noncoding RNAs on human diseases. Here we examined the association of genetic variants located in primary microRNA sequences and long noncoding RNAs (lncRNAs) with Alzheimer disease (AD) by leveraging data from the largest genome-wide association meta-analysis of late-onset AD. Variants annotated to 5 miRNAs and 10 lncRNAs (in ...
Tópico(s): RNA modifications and cancer
2019 - Wiley | Human Mutation
Gözde Sahin, Erik Vrij, Rhiannon Grant, Stefan Giselbrecht,
Multireplication Process In article 2300344, Rhiannon Grant, Stefan Giselbrecht and co-workers demonstrate a multireplication process that enables the faithful replication of electrospun fiber structures on various cell culture substrates. By decoupling fiber diameter, porosity, and material chemistry, this process allows for precise control over fiber morphology. This enables the engineering of well-defined cell microenvironments, facilitating the investigation of complex cell-material interactions.
Tópico(s): Electrospun Nanofibers in Biomedical Applications
2023 - Wiley | Advanced Materials Technologies
Gözde Sahin, Erik Vrij, Rhiannon Grant, Stefan Giselbrecht,
Abstract Electrospinning is a powerful method to fabricate structures resembling the fibrous texture of the native extracellular matrix. However, the random fiber deposition of the process hinders a faithful reproduction of the fiber mesh morphology on multiple samples, which raises difficulties in experimental designs to systematically test and assess cell response in vitro. A multi‐replication process to precisely reproduce the fiber morphology on different cell culture substrates is developed. ...
Tópico(s): Polymer Surface Interaction Studies
2023 - Wiley | Advanced Materials Technologies
Emil D. Manev, Jana K. Angarska,
... and nitrobenzene) foam films were computed by the Vrij (1966) and Radoev–Scheludko–Manev (1983) theories. The ' ... rate of film thinning, instead of the classical Stefan–Reynolds equation.
Tópico(s): Surfactants and Colloidal Systems
2005 - Elsevier BV | Colloids and Surfaces A Physicochemical and Engineering Aspects
Produção Nacional
Revisado por pares
Ziyi Xiong, Gabriela Dankova, Laurence J Howe, Myoung Keun Lee, Pirro G. Hysi, Markus A de Jong, Gu Zhu, Kaustubh Adhikari, Dan Li, Yi Li, Bo Pan, Eleanor Feingold, Mary L. Marazita, John R. Shaffer, Kerrie McAloney, Shuhua Xu, Jin Li, Sijia Wang, Femke M.S. de Vrij, Bas Lendemeijer, Stephen Richmond, Alexei I. Zhurov, Sarah J. Lewis, Gemma C. Sharp, Lavinia Paternoster, Holly Thompson, Rolando González‐José, María Cátira Bortolini, Samuel Canizales‐Quinteros, Carla Gallo, Giovanni Poletti, Gabriel Bedoya, Francisco Rothhammer, André G. Uitterlinden, M. Arfan Ikram, Eppo B. Wolvius, Steven A. Kushner, Tamar Nijsten, Robert‐Jan Palstra, Stefan Böehringer, Sarah E. Medland, Kun Tang, Andrés Ruiz‐Linares, Nicholas G. Martin, Timothy D. Spector, Evie Stergiakouli, Seth M. Weinberg, Fan Liu, Manfred Kayser,
The human face represents a combined set of highly heritable phenotypes, but knowledge on its genetic architecture remains limited, despite the relevance for various fields. A series of genome-wide association studies on 78 facial shape phenotypes quantified from 3-dimensional facial images of 10,115 Europeans identified 24 genetic loci reaching study-wide suggestive association (p < 5 × 10−8), among which 17 were previously unreported. A follow-up multi-ethnic study in additional 7917 individuals confirmed ...
Tópico(s): Morphological variations and asymmetry
2019 - eLife Sciences Publications Ltd | eLife
Produção Nacional
Ziyi Xiong, Haibo Zhou, Gabriela Dankova, Laurence J Howe, Myoung Keun Lee, Pirro G. Hysi, Markus A. de Jong, Gu Zhu, Kaustubh Adhikari, Dan Li, Yi Li, Li He, Bo Pan, Eleanor Feingold, Mary L. Marazita, John R. Shaffer, Kerrie McAloney, Shuhua Xu, Jin Li, Sijia Wang, Femke M.S. de Vrij, Bas Lendemeijer, Stephen Richmond, Alexei I. Zhurov, Erwei Zuo, Sarah J. Lewis, Gemma C. Sharp, Lavinia Paternoster, Holly Thompson, Rolando González‐José, María Cátira Bortolini, Samuel Canizales‐Quinteros, Carla Gallo, Giovanni Poletti, Gabriel Bedoya, Francisco Rothhammer, André G. Uitterlinden, M. Arfan Ikram, Eppo B. Wolvius, Steven A. Kushner, Tamar Nijsten, Robert‐Jan Palstra, Stefan Böehringer, Sarah E. Medland, Kun Tang, Andrés Ruiz‐Linares, Nicholas G. Martin, Hui Yang, Timothy D. Spector, Evie Stergiakouli, Seth M. Weinberg, Fan Liu, Manfred Kayser,
The human face represents a combined set of highly heritable phenotypes, but knowledge on its genetic architecture remains limited. A series of genome-wide association studies on 78 facial shape phenotypes quantified from 3-dimensional facial images of 10,115 Europeans identified 24 genetic loci, among which 17 were previously unpublished. A multi-ethnic replication study in 7,917 individuals confirmed 13 loci including 8 unpublished ones. Allele frequencies at the face-associated loci were significantly ...
Tópico(s): Cleft Lip and Palate Research
2018 - RELX Group (Netherlands) | SSRN Electronic Journal