Anna Maciąg, James P. Stice, Bin Wang, Alok K. Sharma, Albert H. Chan, Ken Lin, Devansh Singh, Marcin Dyba, Yue Yang, Saman Setoodeh, Brian P. Smith, Dana Rabara, Zuhui Zhang, Erik K. Larsen, D.A. Esposito, John Paul Denson, Michela Ranieri, Mary Meynardie, Sadaf Mehdizadeh, Patrick Alexander, Maria Abreu Blanco, David P. Turner, Rui Xu, Felice C. Lightstone, Kwok‐Kin Wong, Dhirendra K. Simanshu, Keshi Wang, Andrew Stephen, Kerstin W. Sinkevicius, Dwight V. Nissley, Eli Wallace, Frank McCormick, Pedro J. Beltran,
... Felice C. Lightstone, Kwok Kin Wong, Dhirendra Simanshu, Keshi Wang, Andrew G. Stephen, Kerstin Sinkevicius, Dwight V. Nissley, Eli Wallace, Frank ...
Tópico(s): Cancer, Hypoxia, and Metabolism
2024 - American Association for Cancer Research | Cancer Research
Keshi Chen, Stephen Demko, Ruifeng Xie,
The color histogram of an image has been widely used as a feature descriptor for the image in content-based retrieval applications. In this paper, we report some results from our investigation efforts into its usage. We outline three typical color space quantization schemes used in our experiments, and introduce the soft-decision histogramming method to eliminate the discontinuity problem in traditional color histogram population process. Then, to improve the effectiveness of color histogram-based ...
Tópico(s): Text and Document Classification Technologies
1998 - SPIE | Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE
... Africa and as the case of Nigeria demonstrates, Stephen Keshi, the national coach, symbolises missed opportunities – i.e. ...
Tópico(s): Sports Analytics and Performance
2016 - Emerald Publishing Limited | Marketing Intelligence & Planning
Stephen L. De Wall, Keshi Wang, Daniel R. Berger, Shigeru Watanabe, Jeanette C. Hernandez, George W. Gokel,
Ten 18-membered ring lariat ether compounds have been prepared as one-, two-, and three-armed derivatives of aza-, diaza-, and triaza-18-crown-6. They include N-[[(3-cholestanyloxy)carbonyl]methyl]aza-18-crown-6, 1, N-tetradecylaza-18-crown-6, 2, N,N‘-dibutyl-4,13-diaza-18-crown-6, 3, N,N‘-dinonyl-4,13-diaza-18-crown-6, 4, N,N‘-didodecyl-4,13-diaza-18-crown-6, 5, N,N‘-ditetradecyl-4,13-diaza-18-crown-6, 6, N,N‘-dioctadecyl-4,13-diaza-18-crown-6, 7, N,N‘-bis[[(3-cholestanyloxy)carbonyl]methyl]-4, ...
Tópico(s): Porphyrin and Phthalocyanine Chemistry
1997 - American Chemical Society | The Journal of Organic Chemistry
Rui Xu, Keshi Wang, James P. Rizzi, Heli Huang, Jonas Grina, Stephen T. Schlachter, Bin Wang, Paul M. Wehn, Hanbiao Yang, Darryl D. Dixon, Robert Czerwiński, Xinlin Du, Emily L. Ged, Guangzhou Han, Huiling Tan, Tai‐Tong Wong, Shanhai Xie, John A. Josey, Eli M. Wallace,
The hypoxia-inducible factor 2α (HIF-2α) is a key oncogenic driver in clear cell renal cell carcinoma (ccRCC). Our first HIF-2α inhibitor PT2385 demonstrated promising proof of concept clinical activity in heavily pretreated advanced ccRCC patients. However, PT2385 was restricted by variable and dose-limited pharmacokinetics resulting from extensive metabolism of PT2385 to its glucuronide metabolite. Herein we describe the discovery of second-generation HIF-2α inhibitor PT2977 with increased potency ...
Tópico(s): Hepatocellular Carcinoma Treatment and Prognosis
2019 - American Chemical Society | Journal of Medicinal Chemistry
Eli M. Wallace, James P. Rizzi, Guangzhou Han, Paul M. Wehn, Zhaodan Cao, Xinlin Du, Tzuling Cheng, Robert Czerwiński, Darryl D. Dixon, Barry S. Goggin, Jonas Grina, Megan M. Halfmann, Melissa A. Maddie, Sarah R. Olive, Stephen T. Schlachter, Huiling Tan, Bin Wang, Keshi Wang, Shanhai Xie, Rui Xu, Hanbiao Yang, John A. Josey,
Abstract More than 90% of clear cell renal cell carcinomas (ccRCC) exhibit inactivation of the von Hippel–Lindau (pVHL) tumor suppressor, establishing it as the major underlying cause of this malignancy. pVHL inactivation results in stabilization of the hypoxia-inducible transcription factors, HIF1α and HIF2α, leading to expression of a genetic program essential for the initiation and progression of ccRCC. Herein, we describe the potent, selective, and orally active small-molecule inhibitor PT2385 ...
Tópico(s): Renal cell carcinoma treatment
2016 - American Association for Cancer Research | Cancer Research
Tai W. Wong, Rajeev Shrimali, Cristina F. Contreras, Tzuling Cheng, Robert Czerwiński, Daryl D. Dixon, Xinlin Du, Craig Fett, Jessica R. Goree, Jonas Grina, Guangzhou Han, Heli Huang, Jim Rizzi, Stephen T. Schlachter, Bin Wang, Keshi Wang, Paul M. Wehn, Shanhai Xie, Rui Xu, Hanbiao Yang, John A. Josey, Eli M. Wallace,
... A. Grina, Guangzhou Han, Heli Huang, Jim Rizzi, Stephen T. Schlachter, Bin Wang, Keshi Wang, Paul M. Wehn, Shanhai Xie, Rui Xu, ...
Tópico(s): Ferroptosis and cancer prognosis
2018 - American Association for Cancer Research | Molecular Cancer Therapeutics
Pedro J. Beltran, Simanshu Dhirendra, Rui Xu, Ming Chen, Daniel J. Czyzyk, Sofia Donovan, Siyu Feng, Cindy Feng, Lijuan Fu, Felice C. Lightstone, Ken Lin, Anna Maciąg, Dwight V. Nissley, Erin Riegler, Kerstin W. Sinkevicius, Andrew Stephen, James P. Stice, David P. Turner, Bin Wang, Keshi Wang, Yue Yang, Cathy Zhang, Frank McCormick, Eli Wallace,
... Maciag, Dwight Nissley, Erin Riegler, Kerstin Sinkevicius, Andrew Stephen, James Stice, David Turner, Bin Wang, Keshi Wang, Yue Yang, Cathy Zhang, Frank McCormick, Eli ...
Tópico(s): Protein Tyrosine Phosphatases
2024 - American Association for Cancer Research | Cancer Research
Akio Nakano, Jeanette C. Hernandez, Stephen L. Dewall, Keshi Wang, Daniel R. Bergerc, George W. Gokel,
Abstract Ten steroid-substituted lariat ether compounds have been prepared including one- and two—armed derivatives of aza-15-crown-5 and aza- and diaza-18-crown-6. They include, N-(3-cholesteryloxycarbonyl-methyl)-aza-15-crown-5, 1, N-(3-dihydrocholesteryloxycarbonylmethyl)-aza-15-crown-5, 2, N-(3-cholesteryloxycarbonylmethyl)-aza-18-crown-6, 3, N-(3-dihydrocholesteryloxycarbonylmethyl)-aza-18-crown-6, 4, N-(3-dihydrocholesteryloxycarbonylpropyl)-aza-15-crown-5, 5, N-(3-dihydrocholesteryloxycarbonylpentyl)- ...
Tópico(s): Analytical Chemistry and Chromatography
1997 - Taylor & Francis | Supramolecular chemistry
Paul M. Wehn, James P. Rizzi, Darryl D. Dixon, Jonas Grina, Stephen T. Schlachter, Bin Wang, Rui Xu, Hanbiao Yang, Xinlin Du, Guangzhou Han, Keshi Wang, Zhaodan Cao, Tzuling Cheng, Robert Czerwiński, Barry S. Goggin, Heli Huang, Megan M. Halfmann, Melissa A. Maddie, Emily L. Morton, Sarah R. Olive, Huiling Tan, Shanhai Xie, Tai‐Tong Wong, John A. Josey, Eli M. Wallace,
HIF-2α, a member of the HIF family of transcription factors, is a key oncogenic driver in cancers such as clear cell renal cell carcinoma (ccRCC). A signature feature of these cancers is the overaccumulation of HIF-2α protein, often by inactivation of the E3 ligase VHL (von Hippel–Lindau). Herein we disclose our structure based drug design (SBDD) approach that culminated in the identification of PT2385, the first HIF-2α antagonist to enter clinical trials. Highlights include the use of a putative n → ...
Tópico(s): Renal cell carcinoma treatment
2018 - American Chemical Society | Journal of Medicinal Chemistry
James P. Stice, Anna E. Maciag, Alok K. Sharma, Albert H. Chan, Ken Lin, Devansh Singh, Marcin Dyba, Yue Yang, Saman Setoodeh, Cathy Zhang, Bryan D. Smith, Dana Rabara, Zuhui Zhang, Erik K. Larsen, John-Paul Denson, Michela Ranieri, Mary Meynardie, Rui Xu, Felice C. Lightstone, Kwok‐Kin Wong, Andrew Stephen, Keshi Wang, Dhirendra K. Simanshu, Kerstin W. Sinkevicius, Dwight V. Nissley, Bin Wang, Eli Wallace, Frank McCormick, Pedro J. Beltran,
Tópico(s): Metabolism, Diabetes, and Cancer
2025 - American Association for Cancer Research | Cancer Research
Anna E. Maciag, James P. Stice, Bin Wang, Alok K. Sharma, Albert H. Chan, Kenneth Lin, Devansh Singh, Marcin Dyba, Yue Yang, Saman Setoodeh, Bryan D. Smith, Jin Hyun Ju, Stevan Jeknic, Dana Rabara, Zuhui Zhang, Erik K. Larsen, Dominic Esposito, John-Paul Denson, Michela Ranieri, Mary Meynardie, Sadaf Mehdizadeh, Patrick Alexander, Maria Abreu Blanco, David M. Turner, Rui Xu, Felice C. Lightstone, Kwok‐Kin Wong, Andrew Stephen, Keshi Wang, Dhirendra K. Simanshu, Kerstin W. Sinkevicius, Dwight V. Nissley, Eli Wallace, Frank McCormick, Pedro J. Beltran,
Abstract Approved inhibitors of KRASG12C prevent oncogenic activation by sequestering the inactive, GDP-bound (OFF) form rather than directly binding and inhibiting the active, GTP-bound (ON) form. This approach provides no direct target coverage of the active protein. Expectedly, adaptive resistance to KRASG12C (OFF)-only inhibitors is observed in association with increased expression and activity of KRASG12C(ON). To provide optimal KRASG12C target coverage, we have developed BBO-8520, a first-in- ...
Tópico(s): Enzyme Structure and Function
2024 - American Association for Cancer Research | Cancer Discovery
Eli M. Wallace, Zhaodan Cao, Tzuling Cheng, Robert Czerwiński, Darryl D. Dixon, Xinlin Du, Barry S. Goggin, Jonas Grina, Megan M. Halfmann, Guangzhou Han, Heli Huang, John A. Josey, Melissa A. Maddie, Sarah R. Olive, James P. Rizzi, Stephen T. Schlachter, Huiling Tan, Bin Wang, Keshi Wang, Paul M. Wehn, Shanhai Xie, Rui Xu, Hanbiao Yang,
... Josey, Melissa A. Maddie, Sarah Olive, James Rizzi, Stephen T. Schlachter, Hui-Ling Tan, Bin Wang, Keshi Wang, Paul M. Wehn, Shanhai Xie, Rui Xu, ...
Tópico(s): Epigenetics and DNA Methylation
2015 - American Association for Cancer Research | Cancer Research
Stephen Demko, Mehdi Khosravi, Keshi Chen,
The Fractal Transform (FT) was originally introduced as a methodology for compressing digital images and representing them at different scales. The process of calculating an FT, generates a great deal of information about the affine similarities and dissimilarities of an image, most of which is discarded in compression applications. In this paper, we introduce the concept of Fractal Transform Analysis, and use it to derive new image descriptors. We present results of experiments in which description ...
Tópico(s): Image Retrieval and Classification Techniques
1998 - SPIE | Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE
Paul M. Wehn, Yang Song, Jonas Grina, James P. Rizzi, Stephen T. Schlachter, Bin Wang, Rui Xu, Hanbiao Yang, Xinlin Du, Guangzhou Han, Keshi Wang, Robert Czerwiński, Emily L. Ged, Heli Huang, Megan M. Halfmann, Melissa A. Maddie, Emily R. Morton, Sarah R. Olive, Huiling Tan, Shanhai Xie, John A. Josey, Eli M. Wallace,
Tópico(s): Fibroblast Growth Factor Research
2023 - Springer Science+Business Media | Medicinal Chemistry Research
Cristóbal Espinosa‐Ruíz, Kanchan Singh, Zuhui Zhang, Kyle A. Sullivan, Nadege Gitego, Megan Rigby, Roger Ma, Patrick Alexander, Saman Setoodeh, Shu Jin, Kenneth Lin, Dana Rabara, Erik K. Larsen, Alok K. Sharma, Albert H. Chan, Bryan D. Smith, Andrew Stephen, Yue Yang, Jun Pei, Felice C. Lightstone, Dhirendra K. Simanshu, Rui Xu, Chunmei Ji, Keshi Wang, Bin Wang, Kerstin W. Sinkevicius, Dwight V. Nissley, Eli Wallace, Frank McCormick, Anna Maciąg, Pedro J. Beltran,
Tópico(s): Cancer Treatment and Pharmacology
2025 - American Association for Cancer Research | Cancer Research