Portal de Periódicos da CAPES

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... repays Souness Bellamy seals bitter scrap with Leeds Blomqvist lifts Everton Fa Barclaycard Premiership Nationwide First Division ... t Pay? Feminists And Flour Bombs Critics choice Stig of The Dump (BBC1, 5.45pm) Last Man ...

2002 - Gale Group | Sunday Times HA GDA

John R. B. Perry, Felix R. Day, Cathy E. Elks, Patrick Sulem, Deborah J. Thompson, Teresa Ferreira, Chunyan He, Daniel I. Chasman, Tõnu Esko, Guðmar Þorleifsson, Eva Albrecht, Wei Ang, Tanguy Corre, Diana L. Cousminer, Bjarke Feenstra, Nora Franceschini, Andrea Ganna, Andrew D. Johnson, Sanela Kjellqvist, Kathryn L. Lunetta, George McMahon, Ilja M. Nolte, Lavinia Paternoster, Eleonora Porcu, Albert V. Smith, Lisette Stolk, Alexander Teumer, Natalia Tšernikova, Emmi Tikkanen, Sheila Ulivi, Erin K. Wagner, Najaf Amin, Laura J. Bierut, Enda M. Byrne, Jouke‐Jan Hottenga, Daniel L. Koller, Massimo Mangino, Tune H. Pers, Laura M. Yerges-Armstrong, Jing Hua Zhao, Irene L. Andrulis, Hoda Anton‐Culver, Femke Atsma, Stefania Bandinelli, Matthias W. Beckmann, Javier Benı́tez, Carl Blomqvist, Stig E. Bojesen, Manjeet K. Bolla, Bernardo Bonanni, Hiltrud Brauch, Hermann Brenner, Julie E. Buring, Jenny Chang‐Claude, Stephen J. Chanock, Jinhui Chen, Georgia Chenevix‐Trench, J. Margriet Collée, Fergus J. Couch, David Couper, Andrea D. Coviello, Angela Cox, Kamila Czene, Pio D’Adamo, George Davey Smith, Immaculata De Vivo, Ellen W. Demerath, Joe Dennis, Peter Devilee, Aida Karina Dieffenbach, Alison M. Dunning, Guðný Eiríksdóttir, Johan G. Eriksson, Peter A. Fasching, Luigi Ferrucci, Dieter Flesch‐Janys, Henrik Flyger, Tatiana Foroud, Lude Franke, Melissa E. Garcia, Montserrat García‐Closas, Frank Geller, Eco J. C. de Geus, Graham G. Giles, Daníel F. Guðbjartsson, Vilmundur Guðnason, Pascal Guénel, Suiqun Guo, Per Hall, Ute Hamann, Robin Haring, Catharina A. Hartman, Andrew C. Heath, Albert Hofman, Maartje J. Hooning, John L. Hopper, Frank B. Hu, David J. Hunter, David Karasik, Douglas P. Kiel, Julia A. Knight, Veli-Matti Kosma, Zoltán Kutalik, Sandra Lai, Diether Lambrechts, Annika Lindblom, Reedik Mägi, Patrik K. E. Magnusson, Graham J. Mann, Nicholas G. Martin, Gísli Másson, Patrick F. McArdle, Wendy L. McArdle, Mads Melbye, Kyriaki Michailidou, Evelin Mihailov, Lili Milani, Roger L. Milne, Heli Nevanlinna, Patrick Neven, Ellen A. Nøhr, Albertine J. Oldehinkel, Ben A. Oostra, Aarno Palotie, Munro Peacock, Nancy L. Pedersen, Paolo Peterlongo, Julian Peto, Paul D.P. Pharoah, Dirkje S. Postma, Anneli Pouta, Katri Pylkäs, Paolo Radice, Susan M. Ring, Fernando Rivadeneira, Antonietta Robino, Lynda M. Rose, Anja Rudolph, Veikko Salomaa, Serena Sanna, David Schlessinger, Marjanka K. Schmidt, Melissa C. Southey, Ulla Sovio, Meir J. Stampfer, Doris Stöckl, Anna Maria Storniolo, Nicholas J. Timpson, Jonathan P. Tyrer, Jenny A. Visser, Péter Vollenweider, Henry Völzke, Gérard Waeber, Mélanie Waldenberger, Henri Wallaschofski, Qin Wang, Gonneke Willemsen, Robert Winqvist, Bruce H. R. Wolffenbuttel, Margaret J. Wright, Dorret I. Boomsma, Michael J. Econs, Kay‐Tee Khaw, Ruth J. F. Loos, Mark I. McCarthy, Grant W. Montgomery, John P. Rice, Elizabeth A. Streeten, Unnur Þorsteinsdóttir, Cornelia M. van Duijn, Behrooz Z. Alizadeh, Sven Bergmann, Eric Boerwinkle, Heather A. Boyd, Laura Crisponi, Paolo Gasparini, Christian Gieger, Tamara B. Harris, Erik Ingelsson, Marjo‐Riitta Järvelin, Peter Kraft, Debbie A. Lawlor, Andres Metspalu, Craig E. Pennell, Paul M. Ridker, Harold Snieder, Thorkild I. A. Sörensen, Tim D. Spector, David P. Strachan, André G. Uitterlinden, Nicholas J. Wareham, Elisabeth Widén, Marek Zygmunt, Anna Murray, Douglas F. Easton, Kári Stéfansson, Joanne M. Murabito, Ken K. Ong,

Tópico(s): Genetic Associations and Epidemiology

2014 - Nature Portfolio | Nature

Qi Guo, Stephen Burgess, Constance Turman, Manjeet K. Bolla, Qin Wang, Michael Lush, Jean Abraham, Kristiina Aittomäki, Irene L. Andrulis, Carmel Apicella, Volker Arndt, Myrto Barrdahl, Javier Benı́tez, Christine D. Berg, Carl Blomqvist, Stig E. Bojesen, Bernardo Bonanni, Judith S. Brand, Hermann Brenner, Annegien Broeks, Barbara Burwinkel, Carlos Caldas, Daniele Campa, Federico Canzian, Jenny Chang‐Claude, Stephen J. Chanock, Suet‐Feung Chin, Fergus J. Couch, Angela Cox, Simon S. Cross, Cezary Cybulski, Kamila Czene, Hatef Darabi, Peter Devilee, W. Ryan Diver, Alison M. Dunning, Helena Earl, Diana Eccles, Arif B. Ekici, Mikael Eriksson, D. Gareth Evans, Peter A. Fasching, Jonine D. Figueroa, Dieter Flesch‐Janys, Henrik Flyger, Susan M. Gapstur, Mia M. Gaudet, Graham G. Giles, Gord Glendon, Mervi Grip, Jacek Gronwald, Lothar Haeberle, Christopher A. Haiman, Per Hall, Ute Hamann, Susan E. Hankinson, Jaana M. Hartikainen, Alexander Hein, Louise Hiller, Frans B.L. Hogervorst, Bernd Holleczek, Maartje J. Hooning, Robert N. Hoover, Keith Humphreys, David J. Hunter, Anika Hüsing, Anna Jakubowska, Arja Jukkola‐Vuorinen, Rudolf Kaaks, Maria Kabisch, Vesa Kataja, Julia A. Knight, Linetta B. Koppert, Veli‐Matti Kosma, Vessela N. Kristensen, Diether Lambrechts, Loı̈c Le Marchand, Jingmei Li, Annika Lindblom, Sara Lindström, Jolanta Lissowska, Jan Lubiński, Mitchell J. Machiela, Graham J. Mann, Siranoush Manoukian, Sara Margolin, F. Marmé, John W.M. Martens, Catriona McLean, Primitiva Menéndez, Roger L. Milne, Anna Marie Mulligan, Taru Muranen, Heli Nevanlinna, Patrick Neven, Sune F. Nielsen, Børge G. Nordestgaard, Janet E. Olson, Jose IA Perez, Paolo Peterlongo, Kelly‐Anne Phillips, Christopher Poole, Katri Pylkäs, Paolo Radice, Nazneen Rahman, Thomas Rüdiger, Anja Rudolph, Elinor J. Sawyer, Fredrick R. Schumacher, Petra Seibold, Caroline Seynaeve, Mitul Shah, Ann Smeets, Melissa C. Southey, Rob A.�E.�M. Tollenaar, Ian Tomlinson, Helen Tsimiklis, Hans-Ulrich Ulmer, Celine M. Vachon, Ans MW van den Ouweland, Laura J. van’t Veer, Hans Wildiers, Walter C. Willett, Robert Winqvist, M. Pilar Zamora, Georgia Chenevix‐Trench, Thilo Dörk, Douglas F. Easton, Montserrat García‐Closas, Peter Kraft, John L. Hopper, Wei Zheng, Marjanka K. Schmidt, Paul D.P. Pharoah,

There is increasing evidence that elevated body mass index (BMI) is associated with reduced survival for women with breast cancer. However, the underlying reasons remain unclear. We conducted a Mendelian randomization analysis to investigate a possible causal role of BMI in survival from breast cancer.

Tópico(s): Genetic factors in colorectal cancer

2017 - Oxford University Press | International Journal of Epidemiology

Olivier Brouckaert, Anja Rudolph, Annouschka Laenen, Renske Keeman, Manjeet K. Bolla, Qin Wang, Adelheid Soubry, Hans Wildiers, Irene L. Andrulis, Volker Arndt, Matthias W. Beckmann, Javier Benı́tez, Carl Blomqvist, Stig E. Bojesen, Hiltrud Brauch, Paul Brennan, Hermann Brenner, Georgia Chenevix‐Trench, Ji‐Yeob Choi, Sten Cornelissen, Fergus J. Couch, Angela Cox, Simon S. Cross, Kamila Czene, Mikael Eriksson, Peter A. Fasching, Jonine D. Figueroa, Henrik Flyger, Graham G. Giles, Anna González‐Neira, Pascal Guénel, Per Hall, Antoinette Hollestelle, John L. Hopper, Hidemi Ito, Michael E. Jones, Daehee Kang, Julia A. Knight, Veli‐Matti Kosma, Jingmei Li, Annika Lindblom, Jenna Lilyquist, Artitaya Lophatananon, Graham J. Mann, Siranoush Manoukian, Sara Margolin, Keitaro Matsuo, Kenneth Muir, Heli Nevanlinna, Paolo Peterlongo, Katri Pylkäs, Suleeporn Saajrang, Caroline Seynaeve, Chen‐Yang Shen, Xiao‐Ou Shu, Melissa C. Southey, Anthony J. Swerdlow, Soo‐Hwang Teo, Rob A.�E.�M. Tollenaar, Thérèse Truong, Chiu-Chen Tseng, Alexandra J. van den Broek, Carolien H. M. van Deurzen, Robert Winqvist, Anna H. Wu, Cheng Har Yip, Jyh-Cherng Yu, Wei Zheng, Roger L. Milne, Paul D.P. Pharoah, Douglas F. Easton, Marjanka K. Schmidt, Montserrat García‐Closas, Jenny Chang‐Claude, Diether Lambrechts, Patrick Neven,

Previous studies have shown that reproductive factors are differentially associated with breast cancer (BC) risk by subtypes. The aim of this study was to investigate associations between reproductive factors and BC subtypes, and whether these vary by age at diagnosis. We used pooled data on tumor markers (estrogen and progesterone receptor, human epidermal growth factor receptor-2 (HER2)) and reproductive risk factors (parity, age at first full-time pregnancy (FFTP) and age at menarche) from 28,095 ...

Tópico(s): Breast Lesions and Carcinomas

2017 - BioMed Central | Breast Cancer Research

Daniele Giardiello, Ewout W. Steyerberg, Michael Hauptmann, Muriel A. Adank, Delal Akdeniz, Carl Blomqvist, Stig E. Bojesen, Manjeet K. Bolla, Mariël Brinkhuis, Jenny Chang‐Claude, Kamila Czene, Peter Devilee, Alison M. Dunning, Douglas F. Easton, Diana Eccles, Peter A. Fasching, Jonine D. Figueroa, Henrik Flyger, Montserrat García‐Closas, Lothar Haeberle, Christopher A. Haiman, Per Hall, Ute Hamann, John L. Hopper, Agnes Jager, Anna Jakubowska, Audrey Jung, Renske Keeman, Iris Kramer, Diether Lambrechts, Loı̈c Le Marchand, Annika Lindblom, Jan Lubiński, Mehdi Manoochehri, Luigi Mariani, Heli Nevanlinna, Hester S. A. Oldenburg, Saskia Pelders, Paul D.P. Pharoah, Mitul Shah, Sabine Siesling, Vincent T.H.B.M. Smit, Melissa C. Southey, William Tapper, Rob A.�E.�M. Tollenaar, Alexandra J. van den Broek, Carolien H. M. van Deurzen, Flora E. van Leeuwen, Chantal Van Ongeval, Laura J. van’t Veer, Qin Wang, Camilla Wendt, Pieter J. Westenend, Maartje J. Hooning, Marjanka K. Schmidt,

Abstract Background Breast cancer survivors are at risk for contralateral breast cancer (CBC), with the consequent burden of further treatment and potentially less favorable prognosis. We aimed to develop and validate a CBC risk prediction model and evaluate its applicability for clinical decision-making. Methods We included data of 132,756 invasive non-metastatic breast cancer patients from 20 studies with 4682 CBC events and a median follow-up of 8.8 years. We developed a multivariable Fine and ...

Tópico(s): Cancer Genomics and Diagnostics

2019 - BioMed Central | Breast Cancer Research

Daniele Giardiello, Michael Hauptmann, Ewout W. Steyerberg, Muriel A. Adank, Delal Akdeniz, Jannet Blom, Carl Blomqvist, Stig E. Bojesen, Manjeet K. Bolla, Mariël Brinkhuis, Jenny Chang‐Claude, Kamila Czene, Peter Devilee, Alison M. Dunning, Douglas F. Easton, Diana Eccles, Peter A. Fasching, Jonine D. Figueroa, Henrik Flyger, Montserrat García‐Closas, Lothar Haeberle, Christopher A. Haiman, Per Hall, Ute Hamann, John L. Hopper, Agnes Jager, Anna Jakubowska, Audrey Jung, Renske Keeman, Linetta B. Koppert, Iris Kramer, Diether Lambrechts, Loı̈c Le Marchand, Annika Lindblom, Jan Lubiński, Mehdi Manoochehri, Luigi Mariani, Heli Nevanlinna, Hester S. A. Oldenburg, Saskia Pelders, Paul D.P. Pharoah, Mitul Shah, Sabine Siesling, Vincent T.H.B.M. Smit, Melissa C. Southey, William Tapper, Rob A.�E.�M. Tollenaar, Alexandra J. van den Broek, Carolien H. M. van Deurzen, Flora E. van Leeuwen, Chantal Van Ongeval, Laura J. van’t Veer, Qin Wang, Camilla Wendt, Pieter J. Westenend, Maartje J. Hooning, Marjanka K. Schmidt,

Three tools are currently available to predict the risk of contralateral breast cancer (CBC). We aimed to compare the performance of the Manchester formula, CBCrisk, and PredictCBC in patients with invasive breast cancer (BC). We analyzed data of 132,756 patients (4682 CBC) from 20 international studies with a median follow-up of 8.8 years. Prediction performance included discrimination, quantified as a time-dependent Area-Under-the-Curve (AUC) at 5 and 10 years after diagnosis of primary BC, and calibration, ...

Tópico(s): Genetic factors in colorectal cancer

2020 - Springer Science+Business Media | Breast Cancer Research and Treatment

Juliette Coignard, Michael Lush, Jonathan Beesley, Tracy A. O’Mara, Joe Dennis, Jonathan P. Tyrer, Daniel R. Barnes, Lesley McGuffog, Goska Leslie, Manjeet K. Bolla, Muriel A. Adank, Simona Agata, Thomas U. Ahearn, Kristiina Aittomäki, Irene L. Andrulis, Hoda Anton‐Culver, Volker Arndt, Norbert Arnold, Kristan J. Aronson, Banu Arun, Annelie Augustinsson, Jacopo Azzollini, Daniel Barrowdale, Caroline Baynes, Heiko Becher, Marina Bermisheva, Leslie Bernstein, Katarzyna Białkowska, Carl Blomqvist, Stig E. Bojesen, Bernardo Bonanni, Åke Borg, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Saundra S. Buys, Trinidad Caldés, Maria A. Caligo, Daniele Campa, Brian D. Carter, Jose E. Castelao, Jenny Chang‐Claude, Stephen J. Chanock, Wendy K. Chung, Kathleen Claes, Christine L. Clarke, Ophélie Bertrand, Sandrine M. Caputo, Anaïs Dupré, Marine Le Mentec, Muriel Belotti, Anne-Marie Birot, Bruno Buecher, Emmanuelle Fourme, Marion Gauthier-Villars, Lisa Golmard, Claude Houdayer, Virginie Moncoutier, Antoine de Pauw, Claire Saule, Olga Sinilnikova, Sylvie Mazoyer, Francesca Damiola, Laure Barjhoux, Carole Verny-Pierre, Mélanie Léone, Nadia Boutry-Kryza, Alain Calender, Sophie Giraud, Olivier Caron, Marine Guillaud-Bataille, Brigitte Bressac–de Paillerets, Yves- Jean Bignon, Nancy Uhrhammer, Christine Lasset, Valérie Bonadona, Pascaline Berthet, Dominique Vaur, Laurent Castéra, Tetsuro Noguchi, Cornel Popovici, Hagay Sobol, Violaine Bourdon, Tetsuro Noguchi, Audrey Remenieras, Catherine Noguès, Isabelle Coupier, Pascal Pujol, Aurélie Dumont, Françoise Révillion, Claude Adenis, Danièle Muller, Emmanuelle Barouk-Simonet, Françoise Bonnet, Virginie Bubien, Nicolas Sevenet, Michel Longy, Christine Toulas, Rosine Guimbaud, Laurence Gladieff, V. Feillel, Dominique Leroux, Hélène Dreyfus, Christine Rebischung, Magalie Peysselon, Fanny Coron, Laurence Faivre, Amandine Baurand, Caroline Jacquot, Geoffrey Bertolone, Sarab Lizard, Fabienne Prieur, Marine Lebrun, Caroline Kientz, Sandra Fert Ferrer, Véronique Mari, Laurence Vénat-Bouvet, Capucine Delnatte, Stéphane Bézieau, Isabelle Mortemousque, Florence Coulet, Chrystelle Colas, Florent Soubrier, Mathilde Warcoin, Johanna Sokolowska, Myriam Bronner, Marie‐Agnès Collonge‐Rame, Alexandre Damette, Paul Gesta, Hakima Lallaoui, Jean Chiésa, Denise Molina-Gomes, Olivier Ingster, Helen Gregory, Zosia Miedzybrodzka, Patrick J. Morrison, Kai-Ren Ong, Alan Donaldson, Mark T. Rogers, Michael J. Kennedy, Mary Porteous, Carole Brewer, Rosemarie Davidson, Louise Izatt, Angela Brady, Julian Barwell, Julian Adlard, Claire Foo, Fiona Lalloo, Lucy Side, Jacqueline Eason, Alex Henderson, Lisa Walker, Rosalind A. Eeles, Jackie Cook, Katie Snape, Diana Eccles, Alex Murray, Emma McCann, Margriet Collée, Don M. Conroy, Kamila Czene, Mary B. Daly, Peter Devilee, Orland Dı́ez, Yuan Chun Ding, Susan M. Domchek, Thilo Dörk, Isabel dos‐Santos‐Silva, Alison M. Dunning, Miriam Dwek, Diana Eccles, A. Heather Eliassen, Christoph Engel, Mikael Eriksson, D. Gareth Evans, Peter A. Fasching, Henrik Flyger, Florentia Fostira, Eitan Friedman, Lin Fritschi, Debra Frost, Manuela Gago‐Dominguez, Susan M. Gapstur, Judy Garber, Vanesa Garcı́a, Montserrat García‐Closas, José Á. García-Sáenz, Mia M. Gaudet, Simon A. Gayther, Andrea Gehrig, Vassilios Georgoulias, Graham G. Giles, Andrew K. Godwin, Mark S. Goldberg, David E. Goldgar, Anna González‐Neira, Mark H. Greene, Pascal Guénel, Lothar Haeberle, Eric Hahnen, Christopher A. Haiman, Niclas Håkansson, Per Hall, Ute Hamann, Patricia A. Harrington, Steven N. Hart, Wei He, Frans B. L. Hogervorst, Antoinette Hollestelle, John L. Hopper, Darling J. Horcasitas, Peter J. Hulick, David J. Hunter, Evgeny N. Imyanitov, Stephen Fox, Ian Campbell, Amanda Spurdle, Penelope M. Webb, Anna de Fazio, Margaret Tassell, Judy Kirk, Geoffrey J. Lindeman, Melanie A. Price, Melissa C. Southey, Roger Milne, Sid Deb, David D.L. Bowtell, Annemieke H. van der Hout, Ans M.W. van den Ouweland, Arjen R. Mensenkamp, Carolien H. M. van Deurzen, Carolien M. Kets, Caroline Seynaeve, Christi J. van Asperen, Cora M. Aalfs, E. Gómez, Flora E. van Leeuwen, Geertruida H. de Bock, Hanne E. J. Meijers-Heijboer, Inge M. Obdeijn, Margriet Collée, J. J. P. Gille, Jan C. Oosterwijk, Juul Wijnen, Lizet E. van der Kolk, Maartje J. Hooning, Margreet G. E. M. Ausems, Marian J. E. Mourits, Marinus J. Blok, Matti A. Rookus, Muriel A. Adank, Rob B. van der Luijt, T. C. T. E. F. van Cronenburg, Carmen C. van der Pol, Nicola S. Russell, Sabine Siesling, Lucy Overbeek, Ruud Wijnands, Judith L. de Lange, Christine L. Clarke, Dinny Graham, Mythily Sachchithananthan, Deborah J. Marsh, Rodney J. Scott, Robert Baxter, Desmond Yip, Jane Carpenter, Alison Davis, Nirmala Pathmanathan, Peter T. Simpson, Agnes Jager, Anna Jakubowska, Paul A. James, Uffe Birk Jensen, Esther M. John, Michael E. Jones, R. Kaaks, Pooja Middha, Beth Y. Karlan, Renske Keeman, Э. К. Хуснутдинова, Johanna I. Kiiski, Yon-Dschun Ko, Veli-Matti Kosma, Peter Kraft, Allison W. Kurian, Yael Laitman, Diether Lambrechts, L. Le Marchand, Jenny Lester, Fabienne Lesueur, Tricia Lindstrom, Adrià López‐Fernández, Jennifer T. Loud, Craig Luccarini,

Breast cancer (BC) risk for BRCA1 and BRCA2 mutation carriers varies by genetic and familial factors. About 50 common variants have been shown to modify BC risk for mutation carriers. All but three, were identified in general population studies. Other mutation carrier-specific susceptibility variants may exist but studies of mutation carriers have so far been underpowered. We conduct a novel case-only genome-wide association study comparing genotype frequencies between 60,212 general population BC ...

Nature Portfolio

Anna Morra, Audrey Jung, Sabine Behrens, Renske Keeman, Thomas U. Ahearn, Hoda Anton‐Culver, Volker Arndt, Annelie Augustinsson, Päivi Auvinen, Laura E. Beane Freeman, Heiko Becher, Matthias W. Beckmann, Carl Blomqvist, Stig E. Bojesen, Manjeet K. Bolla, Hermann Brenner, Ignacio Briceño, Sara Y. Brucker, Nicola J. Camp, Daniele Campa, Federico Canzian, Jose E. Castelao, Stephen J. Chanock, Ji‐Yeob Choi, Christine L. Clarke, Fergus J. Couch, Angela Cox, Simon S. Cross, Kamila Czene, Thilo Dörk, Alison M. Dunning, Miriam Dwek, Douglas F. Easton, Diana Eccles, Kathleen M. Egan, D. Gareth Evans, Peter A. Fasching, Henrik Flyger, Manuela Gago‐Dominguez, Susan M. Gapstur, José Á. García-Sáenz, Mia M. Gaudet, Graham G. Giles, Mervi Grip, Pascal Guénel, Christopher A. Haiman, Niclas Håkansson, Per Hall, Ute Hamann, Sileny Han, Steven N. Hart, Mikael Hartman, Jane Heyworth, Reiner Hoppe, John L. Hopper, David J. Hunter, Hidemi Ito, Agnes Jager, Milena Jakimovska, Anna Jakubowska, Wolfgang Janni, Rudolf Kaaks, Daehee Kang, Pooja Middha, Cari M. Kitahara, Stella Koutros, Peter Kraft, Vessela N. Kristensen, James V. Lacey, Diether Lambrechts, Loı̈c Le Marchand, Jingmei Li, Annika Lindblom, Jan Lubiński, Michael Lush, Arto Mannermaa, Mehdi Manoochehri, Sara Margolin, Shivaani Mariapun, Keitaro Matsuo, Dimitrios Mavroudis, Roger L. Milne, Taru Muranen, William G. Newman, Dong‐Young Noh, Børge G. Nordestgaard, Nadia Obi, Andrew F. Olshan, Håkan Olsson, Tjoung‐Won Park‐Simon, Christos Petridis, Paul D.P. Pharoah, Dijana Plaseska‐Karanfilska, Nadège Presneau, Muhammad Usman Rashid, Gad Rennert, Hedy S. Rennert, Valerie Rhenius, Atocha Romero, Emmanouil Saloustros, Elinor J. Sawyer, Andreas Schneeweiß, Lukas Schwentner, Christopher G. Scott, Mitul Shah, Chen‐Yang Shen, Xiao‐Ou Shu, Melissa C. Southey, Daniel O. Stram, Rulla M. Tamimi, William Tapper, Rob A.�E.�M. Tollenaar, Ian Tomlinson, Diana Torres, Melissa A. Troester, Thérèse Truong, Celine M. Vachon, Qin Wang, Sophia Wang, Justin A. Williams, Robert Winqvist, Alicja Wolk, Anna H. Wu, Keun-Young Yoo, Jyh‐Cherng Yu, Wei Zheng, Argyrios Ziogas, Xiaohong R. Yang, A. Heather Eliassen, Michelle D. Holmes, Montserrat García‐Closas, Soo‐Hwang Teo, Marjanka K. Schmidt, Jenny Chang‐Claude,

Abstract Background: It is not known whether modifiable lifestyle factors that predict survival after invasive breast cancer differ by subtype. Methods: We analyzed data for 121,435 women diagnosed with breast cancer from 67 studies in the Breast Cancer Association Consortium with 16,890 deaths (8,554 breast cancer specific) over 10 years. Cox regression was used to estimate associations between risk factors and 10-year all-cause mortality and breast cancer–specific mortality overall, by estrogen ...

Tópico(s): Breast Cancer Treatment Studies

2021 - American Association for Cancer Research | Cancer Epidemiology Biomarkers & Prevention

Thomas U. Ahearn, Haoyu Zhang, Kyriaki Michailidou, Roger L. Milne, Manjeet K. Bolla, Joe Dennis, Alison M. Dunning, Michael Lush, Qin Wang, Irene L. Andrulis, Hoda Anton‐Culver, Volker Arndt, Kristan J. Aronson, Paul L. Auer, Annelie Augustinsson, Adinda Baten, Heiko Becher, Sabine Behrens, Javier Benı́tez, Marina Bermisheva, Carl Blomqvist, Stig E. Bojesen, Bernardo Bonanni, Anne‐Lise Børresen‐Dale, Hiltrud Brauch, Hermann Brenner, Angela Brooks‐Wilson, Thomas Brüning, Barbara Burwinkel, Saundra S. Buys, Federico Canzian, Jose E. Castelao, Jenny Chang‐Claude, Stephen J. Chanock, Georgia Chenevix‐Trench, Christine L. Clarke, Kristine Kleivi Sahlberg, Lars Ottestad, Rolf Kåresen, Ellen Schlichting, Marit Muri Holmen, Toril Sauer, Vilde Drageset Haakensen, Olav Engebråten, Bjørn Naume, Alexander Fosså, Cecile E. Kiserud, Kristin V. Reinertsen, Åslaug Helland, Margit Riis, Jürgen Geisler, J. Margriet Collée, Angela Cox, Simon S. Cross, Kamila Czene, Mary B. Daly, Peter Devilee, Thilo Dörk, Miriam Dwek, Diana Eccles, D. Gareth Evans, Peter A. Fasching, Jonine D. Figueroa, Giuseppe Floris, Manuela Gago‐Dominguez, Susan M. Gapstur, José Á. García-Sáenz, Mia M. Gaudet, Graham G. Giles, Mark S. Goldberg, Anna González‐Neira, Grethe I.G. Alnæs, Mervi Grip, Pascal Guénel, Christopher A. Haiman, Per Hall, Ute Hamann, Elaine F. Harkness, Bernadette A. M. Heemskerk‐Gerritsen, Bernd Holleczek, Antoinette Hollestelle, Maartje J. Hooning, Robert N. Hoover, John L. Hopper, Anthony Howell, Christine L. Clarke, Rosemary L. Balleine, Robert C. Baxter, Stephen Braye, Jane Carpenter, Jane E. Dahlstrom, John Forbes, CSoon Lee, Deborah J. Marsh, Adrienne Morey, Nirmala Pathmanathan, Rodney J. Scott, Peter T. Simpson, Allan D. Spigelman, Nicholas Wilcken, Desmond Yip, Nikolajs Zeps, Stephen B. Fox, Ian Campbell, David D.L. Bowtell, Georgia Chenevix‐Trench, Amanda B. Spurdle, Penelope M. Webb, Anna de Fazio, Margaret Tassell, Judy Kirk, Geoffrey J. Lindeman, Melanie A. Price, Melissa C. Southey, Roger L. Milne, Sid Deb, Milena Jakimovska, Anna Jakubowska, Esther M. John, Michael E. Jones, Audrey Jung, Rudolf Kaaks, Saila Kauppila, Renske Keeman, Э. К. Хуснутдинова, Cari M. Kitahara, Yon‐Dschun Ko, Stella Koutros, Vessela N. Kristensen, Ute Krüger, Katerina Kubelka‐Sabit, Allison W. Kurian, Kyriacos Kyriacou, Diether Lambrechts, Derrick G. Lee, Annika Lindblom, Martha S. Linet, Jolanta Lissowska, Ana Llaneza, Wing‐Yee Lo, Robert J. MacInnis, Graham J. Mann, Mehdi Manoochehri, Sara Margolin, Marı́a Elena Martı́nez, Catriona McLean, Alfons Meindl, Usha Menon, Heli Nevanlinna, William G. Newman, Jesse Nodora, Kenneth Offit, Håkan Olsson, Nick Orr, Tjoung‐Won Park‐Simon, Alpa V. Patel, Julian Peto, Guillermo Pita, Dijana Plaseska-Karanfilska, Ross L. Prentice, Kevin Punie, Katri Pylkäs, Paolo Radice, Gad Rennert, Atocha Romero, Thomas Rüdiger, Emmanouil Saloustros, Sarah N. Sampson, Dale P. Sandler, Elinor J. Sawyer, Rita K. Schmutzler, Minouk J. Schoemaker, Ben Schöttker, Mark E. Sherman, Xiao‐Ou Shu, Snezhana Smichkoska, Melissa C. Southey, John J. Spinelli, Anthony J. Swerdlow, Rulla M. Tamimi, William Tapper, Jack A. Taylor, Lauren R. Teras, Mary Beth Terry, Diana Torres, Melissa A. Troester, Celine M. Vachon, Carolien H. M. van Deurzen, Elke M. van Veen, Philippe Wagner, Clarice R. Weinberg, Camilla Wendt, Jelle Wesseling, Robert Winqvist, Alicja Wolk, Xiaohong R. Yang, Wei Zheng, Fergus J. Couch, Jacques Simard, Peter Kraft, Douglas F. Easton, Paul D.P. Pharoah, Marjanka K. Schmidt, Montserrat García‐Closas, Nilanjan Chatterjee,

Abstract Background Genome-wide association studies (GWAS) have identified multiple common breast cancer susceptibility variants. Many of these variants have differential associations by estrogen receptor (ER) status, but how these variants relate with other tumor features and intrinsic molecular subtypes is unclear. Methods Among 106,571 invasive breast cancer cases and 95,762 controls of European ancestry with data on 173 breast cancer variants identified in previous GWAS, we used novel two-stage ...

Tópico(s): Breast Cancer Treatment Studies

2022 - BioMed Central | Breast Cancer Research

Anna Morra, Nasim Mavaddat, Taru Muranen, Thomas U. Ahearn, Jamie Allen, Irene L. Andrulis, Päivi Auvinen, Heiko Becher, Sabine Behrens, Carl Blomqvist, Stig E. Bojesen, Manjeet K. Bolla, Hiltrud Brauch, Nicola J. Camp, Sara Carvalho, Jose E. Castelao, Melissa H. Cessna, Jenny Chang‐Claude, Georgia Chenevix‐Trench, Kamila Czene, Brennan Decker, Joe Dennis, Thilo Dörk, Leila Dorling, Alison M. Dunning, Arif B. Ekici, Mikael Eriksson, D. Gareth Evans, Peter A. Fasching, Jonine D. Figueroa, Henrik Flyger, Manuela Gago‐Dominguez, Montserrat García‐Closas, Willemina R.R. Geurts-Giele, Graham G. Giles, Pascal Guénel, Melanie Gündert, Eric Hahnen, Per Hall, Ute Hamann, Patricia Harrington, Wei He, Päivi Heikkilä, Maartje J. Hooning, Reiner Hoppe, Sacha J. Howell, Keith Humphreys, Anna Jakubowska, Audrey Jung, Renske Keeman, Vessela N. Kristensen, Jan Lubiński, Graham J. Mann, Mehdi Manoochehri, Siranoush Manoukian, Sara Margolin, Dimitrios Mavroudis, Roger L. Milne, Anna Marie Mulligan, William G. Newman, Tjoung‐Won Park‐Simon, Paolo Peterlongo, Paul D.P. Pharoah, Valerie Rhenius, Emmanouil Saloustros, Elinor J. Sawyer, Rita K. Schmutzler, Mitul Shah, Amanda B. Spurdle, Ian Tomlinson, Thérèse Truong, Elke M. van Veen, Maaike P.G. Vreeswijk, Qin Wang, Camilla Wendt, Xiaohong R. Yang, Heli Nevanlinna, Peter Devilee, Douglas F. Easton, Marjanka K. Schmidt, Kristine Kleivi Sahlberg, Anne‐Lise Børresen‐Dale, Inger Torhild Gram, Karina Standahl Olsen, Olav Engebråten, Bjørn Naume, Jürgen Geisler, OSBREAC, Grethe I.G. Alnæs, David J. Amor, Lesley Andrews, Yoland Antill, Rosemary L. Balleine, Jonathan Beesley, Ian Bennett, Michael Bogwitz, Leon Botes, Meagan Brennan, Melissa A. Brown, Michael F. Buckley, Jo Burke, Phyllis Butow, Liz Caldon, Ian Campbell, Michelle Cao, Anannya Chakrabarti, Deepa Chauhan, Manisha Chauhan, Georgia Chenevix‐Trench, Alice Christian, Paul A. Cohen, Alison Colley, Ashley Crook, James Cui, Eliza Courtney, Margaret C. Cummings, Sarah‐Jane Dawson, Anna deFazio, Martin Delatycki, Rebecca Dickson, Joanne Dixon, Ted Edkins, Stacey L. Edwards, Gelareh Farshid, Andrew Fellows, Georgina Fenton, Michael Field, James M. Flanagan, Peter C.C. Fong, Laura Forrest, Stephen B. Fox, Juliet D. French, Michael Friedlander, Clara Gaff, Mike Gattas, Peter George, Sian Greening, Marion Harris, Stewart Hart, Nicholas K. Hayward, John L. Hopper, Cass Hoskins, Clare Hunt, Paul A. James, Mark A. Jenkins, Alexa Kidd, Judy Kirk, Jessica Koehler, James Kollias, Sunil R. Lakhani, Mitchell Lawrence, Jason Lee, Shuai Li, Geoffrey J. Lindeman, Lara Lipton, Liz Lobb, Sherene Loi, Graham J. Mann, Deborah J. Marsh, Sue Anne McLachlan, Bettina Meiser, Roger L. Milne, Sophie Nightingale, Shona O’Connell, Sarah O’Sullivan, David Gallego‐Ortega, Nick Pachter, Jia‐Min Pang, Gargi Pathak, Briony Patterson, Amy Pearn, Kelly‐Anne Phillips, Ellen Pieper, Susan J. Ramus, Edwina Rickard, Bridget A. Robinson, Mona Saleh, Anita Skandarajah, Elizabeth Salisbury, Christobel Saunders, Jodi M. Saunus, Rodney J. Scott, Clare L. Scott, Adrienne Sexton, Andrew N. Shelling, Peter T. Simpson, Melissa C. Southey, Amanda B. Spurdle, Jessica Taylor, Renea A. Taylor, Heather Thorne, Alison H. Trainer, Kathy Tucker, Jane E. Visvader, Logan C. Walker, Rachael Williams, Ingrid Winship, Mary Ann Young, Milita Zaheed,

Evidence linking coding germline variants in breast cancer (BC)-susceptibility genes other than BRCA1, BRCA2, and CHEK2 with contralateral breast cancer (CBC) risk and breast cancer-specific survival (BCSS) is scarce. The aim of this study was to assess the association of protein-truncating variants (PTVs) and rare missense variants (MSVs) in nine known (ATM, BARD1, BRCA1, BRCA2, CHEK2, PALB2, RAD51C, RAD51D, and TP53) and 25 suspected BC-susceptibility genes with CBC risk and BCSS. Hazard ratios (HRs) ...

Tópico(s): Genomic variations and chromosomal abnormalities

2023 - Elsevier BV | The American Journal of Human Genetics

Isabelle Grootes, Renske Keeman, Fiona M. Blows, Roger L. Milne, Graham G. Giles, Anthony J. Swerdlow, Peter A. Fasching, Mustapha Abubakar, Irene L. Andrulis, Hoda Anton‐Culver, Matthias W. Beckmann, Carl Blomqvist, Stig E. Bojesen, Manjeet K. Bolla, Bernardo Bonanni, Ignacio Briceño, Barbara Burwinkel, Nicola J. Camp, Jose E. Castelao, Ji‐Yeob Choi, Christine L. Clarke, Fergus J. Couch, Angela Cox, Simon S. Cross, Kamila Czene, Peter Devilee, Thilo Dörk, Alison M. Dunning, Miriam Dwek, Douglas F. Easton, Diana Eccles, Mikael Eriksson, Kristina Ernst, D. Gareth Evans, Jonine D. Figueroa, Visnja Fink, Giuseppe Floris, Stephen B. Fox, Marike Gabrielson, Manuela Gago‐Dominguez, José Á. García-Sáenz, Anna González‐Neira, Lothar Haeberle, Christopher A. Haiman, Per Hall, Ute Hamann, Elaine F. Harkness, Mikael Hartman, Alexander Hein, Maartje J. Hooning, Ming‐Feng Hou, Sacha J. Howell, Hidemi Ito, Anna Jakubowska, Wolfgang Janni, Esther M. John, Audrey Jung, Daehee Kang, Vessela N. Kristensen, Ava Kwong, Diether Lambrechts, Jingmei Li, Jan Lubiński, Mehdi Manoochehri, Sara Margolin, Keitaro Matsuo, Nur Aishah Mohd Taib, Anna Marie Mulligan, Heli Nevanlinna, William G. Newman, Kenneth Offit, Ana Osório, Sue K. Park, Tjoung‐Won Park‐Simon, Alpa V. Patel, Nadège Presneau, Katri Pylkäs, Brigitte Rack, Paolo Radice, Gad Rennert, Atocha Romero, Emmanouil Saloustros, Elinor J. Sawyer, Andreas Schneeweiß, Fabienne Schochter, Minouk J. Schoemaker, Chen‐Yang Shen, Rana Shibli, Hans‐Peter Sinn, William Tapper, Essa Tawfiq, Soo‐Hwang Teo, Lauren R. Teras, Diana Torres, Celine M. Vachon, Carolien H. M. van Deurzen, Camilla Wendt, Justin A. Williams, Robert Winqvist, Mark Elwood, Marjanka K. Schmidt, Montserrat García‐Closas, Paul D.P. Pharoah,

Predict Breast (www.predict.nhs.uk) is an online prognostication and treatment benefit tool for early invasive breast cancer. The aim of this study was to incorporate the prognostic effect of progesterone receptor (PR) status into a new version of PREDICT and to compare its performance to the current version (2.2).

Tópico(s): Breast Lesions and Carcinomas

2022 - Elsevier BV | European Journal of Cancer

Daniele Giardiello, Maartje J. Hooning, Michael Hauptmann, Renske Keeman, Bernadette A. M. Heemskerk‐Gerritsen, Heiko Becher, Carl Blomqvist, Stig E. Bojesen, Manjeet K. Bolla, Nicola J. Camp, Kamila Czene, Peter Devilee, Diana Eccles, Peter A. Fasching, Jonine D. Figueroa, Henrik Flyger, Montserrat García‐Closas, Christopher A. Haiman, Ute Hamann, John L. Hopper, Anna Jakubowska, Floor E. Leeuwen, Annika Lindblom, Jan Lubiński, Sara Margolin, Marı́a Elena Martı́nez, Heli Nevanlinna, Ines Nevelsteen, Saskia Pelders, Paul D.P. Pharoah, Sabine Siesling, Melissa C. Southey, Annemieke H. van der Hout, Liselotte P. van Hest, Jenny Chang‐Claude, Per Hall, Douglas F. Easton, Ewout W. Steyerberg, Marjanka K. Schmidt,

Abstract Background Prediction of contralateral breast cancer (CBC) risk is challenging due to moderate performances of the known risk factors. We aimed to improve our previous risk prediction model (PredictCBC) by updated follow-up and including additional risk factors. Methods We included data from 207,510 invasive breast cancer patients participating in 23 studies. In total, 8225 CBC events occurred over a median follow-up of 10.2 years. In addition to the previously included risk factors, PredictCBC- ...

Tópico(s): Cancer Genomics and Diagnostics

2022 - BioMed Central | Breast Cancer Research

Yosr Hamdi, Penny Soucy, Véronique Adoue, Kyriaki Michailidou, Sander Canisius, Audrey Lemaçon, Arnaud Droit, Irene L. Andrulis, Hoda Anton‐Culver, Volker Arndt, Caroline Baynes, Carl Blomqvist, Natalia Bogdanova, Stig E. Bojesen, Manjeet K. Bolla, Bernardo Bonanni, Anne‐Lise Børresen‐Dale, Judith S. Brand, Hiltrud Brauch, Hermann Brenner, Annegien Broeks, Barbara Burwinkel, Jenny Chang‐Claude, Fergus J. Couch, Angela Cox, Simon S. Cross, Kamila Czene, Hatef Darabi, Joe Dennis, Peter Devilee, Thilo Dörk, Isabel dos‐Santos‐Silva, Mikael Eriksson, Peter A. Fasching, Jonine D. Figueroa, Flyger Henrik, Montserrat García‐Closas, Graham G. Giles, Mark S. Goldberg, Anna González‐Neira, Grethe Irene Grenaker-Alnæs, Pascal Guénel, Lothar Haeberle, Christopher A. Haiman, Ute Hamann, Emily Hallberg, Maartje J. Hooning, John L. Hopper, Anna Jakubowska, Michael E. Jones, Maria Kabisch, Vesa Kataja, Diether Lambrechts, Loı̈c Le Marchand, Annika Lindblom, Jan Lubiński, Arto Mannermaa, Mel Maranian, Sara Margolin, Frederik Marme, Roger L. Milne, Susan L. Neuhausen, Heli Nevanlinna, Patrick Neven, Curtis Olswold, Julian Peto, Dijana Plaseska‐Karanfilska, Katri Pylkäs, Paolo Radice, Anja Rudolph, Elinor J. Sawyer, Marjanka K. Schmidt, Xiao-Ou Shu, Melissa C. Southey, Anthony J. Swerdlow, Rob A.�E.�M. Tollenaar, Ian Tomlinson, Diana Torres, Thérèse Truong, Celine M. Vachon, Ans M.W. van den Ouweland, Qin Wang, Robert Winqvist, kConFab AOCS Investigators, Wei Zheng, Javier Benı́tez, Georgia Chenevix‐Trench, Alison M. Dunning, Paul D.P. Pharoah, Vessela N. Kristensen, Per Hall, Douglas F. Easton, Tomi Pastinen, Silje Nord, Jacques Simard,

... 11 , Volker Arndt 12 , Caroline Baynes 13 , Carl Blomqvist 14 , Natalia V. Bogdanova 15,16 , Stig E. Bojesen 17,18,19 , Manjeet K. Bolla ...

Tópico(s): Genomics and Chromatin Dynamics

2016 - Impact Journals LLC | Oncotarget

Fergus J. Couch, Karoline Kuchenbaecker, Kyriaki Michailidou, Gustavo Mendoza-Fandiño, Silje Nord, Janna Lilyquist, Curtis Olswold, Emily Hallberg, Simona Agata, Habibul Ahsan, Kristiina Aittomäki, Christine B. Ambrosone, Irene L. Andrulis, Hoda Anton‐Culver, Volker Arndt, Banu K. Arun, Brita Arver, Monica Barile, Rósa B. Barkardóttir, Daniel Barrowdale, Lars Beckmann, Matthias W. Beckmann, Javier Benı́tez, Stephanie V. Blank, Carl Blomqvist, Natalia Bogdanova, Stig E. Bojesen, Manjeet K. Bolla, Bernardo Bonanni, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Saundra S. Buys, Trinidad Caldés, Maria A. Caligo, Federico Canzian, Jane Carpenter, Jenny Chang‐Claude, Stephen J. Chanock, Wendy K. Chung, Kathleen Claes, Angela Cox, Simon S. Cross, Julie M. Cunningham, Kamila Czene, Mary B. Daly, Francesca Damiola, Hatef Darabi, Miguel de la Hoya, Peter Devilee, Orland Dı́ez, Yuan Chun Ding, Riccardo Dolcetti, Susan M. Domchek, Cecilia M. Dorfling, Isabel dos‐Santos‐Silva, Martine Dumont, Alison M. Dunning, Diana Eccles, Hans Ehrencrona, Arif B. Ekici, Heather Eliassen, Ian O. Ellis, Peter A. Fasching, Jonine D. Figueroa, Dieter Flesch‐Janys, Asta Försti, Florentia Fostira, William D. Foulkes, Tara M. Friebel, Eitan Friedman, Debra Frost, Marike Gabrielson, Marilie D. Gammon, Patricia A. Ganz, Susan M. Gapstur, Judy E. Garber, Mia M. Gaudet, Simon A. Gayther, Anne–Marie Gerdes, Maya Ghoussaini, Graham G. Giles, Gord Glendon, Andrew K. Godwin, Mark S. Goldberg, David E. Goldgar, Anna González‐Neira, Mark H. Greene, Jacek Gronwald, Pascal Guénel, Marc J. Gunter, Lothar Haeberle, Christopher A. Haiman, Ute Hamann, Thomas van Overeem Hansen, Steven N. Hart, Sue Healey, Tuomas Heikkinen, Brian E. Henderson, Josef Herzog, Frans B.L. Hogervorst, Antoinette Hollestelle, Maartje J. Hooning, Robert N. Hoover, John L. Hopper, Keith Humphreys, David J. Hunter, Tomasz Huzarski, Evgeny N. Imyanitov, Claudine Isaacs, Anna Jakubowska, Paul A. James, Ramūnas Janavičius, Uffe Birk Jensen, Esther M. John, Michael E. Jones, Maria Kabisch, Siddhartha Kar, Beth Y. Karlan, Sofia Khan, Kay‐Tee Khaw, Muhammad G. Kibriya, Julia A. Knight, Yon‐Dschun Ko, Irene Konstantopoulou, Veli-Matti Kosma, Vessela N. Kristensen, Ava Kwong, Yael Laitman, Diether Lambrechts, Conxi Lázaro, Eunjung Lee, Loı̈c Le Marchand, Jenny Lester, Annika Lindblom, Noralane M. Lindor, Sara Lindström, Jianjun Liu, Jirong Long, Jan Lubiński, L. Phuong, Enes Makalic, Kathleen E. Malone, Graham J. Mann, Siranoush Manoukian, Sara Margolin, Frederik Marmé, John W.M. Martens, Lesley McGuffog, Alfons Meindl, Austin Miller, Roger L. Milne, Penelope Miron, Marco Montagna, Sylvie Mazoyer, Anna Marie Mulligan, Taru Muranen, Katherine L. Nathanson, Susan L. Neuhausen, Heli Nevanlinna, Børge G. Nordestgaard, Robert L. Nussbaum, Kenneth Offit, Edith Oláh, Olufunmilayo I. Olopade, Janet E. Olson, Ana Osório, Sue K. Park, Petra H. Peeters, Bernard Peissel, Paolo Peterlongo, Julian Peto, Catherine M. Phelan, Robert Pilarski, Bruce Poppe, Katri Pylkäs, Paolo Radice, Nazneen Rahman, Johanna Rantala, Christine Rappaport, Gad Rennert, Andrea Richardson, Mark E. Robson, Isabelle Romieu, Anja Rudolph, Emiel J. Rutgers, María‐José Sánchez, Regina M. Santella, Elinor J. Sawyer, Daniel F. Schmidt, Marjanka K. Schmidt, Rita K. Schmutzler, Fredrick R. Schumacher, Rodney J. Scott, Leigha Senter, Priyanka Sharma, Jacques Simard, Christian F. Singer, Olga M. Sinilnikova, Penny Soucy, Melissa C. Southey, Doris Steinemann, Marie Stenmark‐Askmalm, Dominique Stoppa‐Lyonnet, Anthony J. Swerdlow, Csilla I. Szabo, Rulla M. Tamimi, William Tapper, Manuel R. Teixeira, Soo‐Hwang Teo, Mary Beth Terry, Mads Thomassen, Deborah J. Thompson, Laima Tihomirova, Amanda E. Toland, Robert A.E.M. Tollenaar, Ian Tomlinson, Thérèse Truong, Helen Tsimiklis, Àlex Teulé, ­Rosario ­Tumino, Nadine Tung, Clare Turnbull, Giske Ursin, Carolien H. M. van Deurzen, Elizabeth J. van Rensburg, Raymonda Varon-Mateeva, Zhaoming Wang, Shan Wang‐Gohrke, Elisabete Weiderpass, Jeffrey N. Weitzel, Alice S. Whittemore, Hans Wildiers, Robert Winqvist, Xiaohong R. Yang, Drakoulis Yannoukakos, Song Yao, M. Pilar Zamora, Wei Zheng, Per Hall, Peter Kraft, Celine M. Vachon, Susan Slager, Georgia Chenevix‐Trench, Paul D.P. Pharoah, Álvaro N.A. Monteiro, Montserrat García‐Closas, Douglas F. Easton, Antonis C. Antoniou,

Abstract Common variants in 94 loci have been associated with breast cancer including 15 loci with genome-wide significant associations ( P <5 × 10 −8 ) with oestrogen receptor (ER)-negative breast cancer and BRCA1 -associated breast cancer risk. In this study, to identify new ER-negative susceptibility loci, we performed a meta-analysis of 11 genome-wide association studies (GWAS) consisting of 4,939 ER-negative cases and 14,352 controls, combined with 7,333 ER-negative cases and 42,468 controls and 15,252 ...

Tópico(s): Genomics and Chromatin Dynamics

2016 - Nature Portfolio | Nature Communications

Kyriaki Michailidou, Sara Lindström, Joe Dennis, Jonathan Beesley, Shirley Hui, Siddhartha Kar, Audrey Lemaçon, Penny Soucy, Dylan M. Glubb, Asha Rostamianfar, Manjeet K. Bolla, Qin Wang, Jonathan P. Tyrer, Ed Dicks, Andrew Lee, Zhaoming Wang, Jamie Allen, Renske Keeman, Ursula Eilber, Juliet D. French, Xiaohong Chen, Laura Fachal, Karen McCue, Amy E. McCart Reed, Maya Ghoussaini, Jason S. Carroll, Xia Jiang, Hilary K. Finucane, Marcia Adams, Muriel A. Adank, Habibul Ahsan, Kristiina Aittomäki, Hoda Anton‐Culver, Natalia Antonenkova, Volker Arndt, Kristan J. Aronson, Banu K. Arun, Paul L. Auer, François Bacot, Myrto Barrdahl, Caroline Baynes, Matthias W. Beckmann, Sabine Behrens, Javier Benı́tez, Marina Bermisheva, Leslie Bernstein, Carl Blomqvist, Natalia Bogdanova, Stig E. Bojesen, Bernardo Bonanni, Anne‐Lise Børresen‐Dale, Judith S. Brand, Hiltrud Brauch, Paul Brennan, Hermann Brenner, Louise A. Brinton, Per Broberg, Ian W. Brock, Annegien Broeks, Angela Brooks‐Wilson, Sara Y. Brucker, Thomas Brüning, Barbara Burwinkel, Katja Butterbach, Qiuyin Cai, Hui Cai, Trinidad Caldés, Federico Canzian, Ángel Carracedo, Brian D. Carter, Jose E. Castelao, Tsun Leung Chan, Ting‐Yuan David Cheng, Kee Seng Chia, Ji‐Yeob Choi, Hans Christiansen, Christine L. Clarke, Margriet Collée, Don Conroy, Emilie Cordina‐Duverger, Sten Cornelissen, David G. Cox, Angela Cox, Simon S. Cross, Julie M. Cunningham, Kamila Czene, Mary B. Daly, Peter Devilee, Kimberly F. Doheny, Thilo Dörk, Isabel dos‐Santos‐Silva, Martine Dumont, Lorraine Durcan, Miriam Dwek, Diana Eccles, Arif B. Ekici, A. Heather Eliassen, Carolina Ellberg, Mingajeva Elvira, Christoph Engel, Mikael Eriksson, Peter A. Fasching, Jonine D. Figueroa, Dieter Flesch‐Janys, Olivia Fletcher, Henrik Flyger, Lin Fritschi, Valérie Gaborieau, Marike Gabrielson, Manuela Gago‐Dominguez, Yu‐Tang Gao, Susan M. Gapstur, José Á. García-Sáenz, Mia M. Gaudet, V. Georgoulias, Graham G. Giles, Gord Glendon, Mark S. Goldberg, David E. Goldgar, Anna González‐Neira, Grethe I.G. Alnæs, Mervi Grip, Jacek Gronwald, Anne Grundy, Pascal Guénel, Lothar Haeberle, Eric Hahnen, Christopher A. Haiman, Niclas Håkansson, Ute Hamann, Nathalie Hamel, Susan E. Hankinson, Patricia Harrington, Steven N. Hart, Jaana M. Hartikainen, Mikael Hartman, Alexander Hein, Jane Heyworth, Belynda Hicks, Peter Hillemanns, Dona N. Ho, Antoinette Hollestelle, Maartje J. Hooning, Robert N. Hoover, John L. Hopper, Ming‐Feng Hou, Chia‐Ni Hsiung, Guanmengqian Huang, Keith Humphreys, Junko Ishiguro, Hidemi Ito, Motoki Iwasaki, Hiroji Iwata, Anna Jakubowska, Wolfgang Janni, Esther M. John, Nichola Johnson, Kristine Jones, Michael E. Jones, Arja Jukkola‐Vuorinen, Rudolf Kaaks, Maria Kabisch, Katarzyna Kaczmarek, Daehee Kang, Yoshio Kasuga, Michael J. Kerin, Sofia Khan, Э. К. Хуснутдинова, Johanna I. Kiiski, Sung-Won Kim, Julia A. Knight, Veli‐Matti Kosma, Vessela N. Kristensen, Ute Krüger, Ava Kwong, Diether Lambrechts, Loı̈c Le Marchand, Eunjung Lee, Min Hyuk Lee, Jong Won Lee, Chuen Neng Lee, Flavio Lejbkowicz, Jingmei Li, Jenna Lilyquist, Annika Lindblom, Jolanta Lissowska, Wing‐Yee Lo, Sibylle Loibl, Jirong Long, Artitaya Lophatananon, Jan Lubiński, Craig Luccarini, Michael P. Lux, Edmond S.K., Robert J. MacInnis, Tom Maishman, Enes Makalic, Kathleen E. Malone, Ivana Maleva Kostovska, Graham J. Mann, Siranoush Manoukian, JoAnn E. Manson, Sara Margolin, Shivaani Mariapun, Marı́a Elena Martı́nez, Keitaro Matsuo, Dimitrios Mavroudis, James McKay, Catriona McLean, Hanne Meijers‐Heijboer, Alfons Meindl, Primitiva Menéndez, Usha Menon, Jeffery Meyer, Hui Miao, Nicola Miller, Nur Aishah Mohd Taib, Kenneth Muir, Anna Marie Mulligan, Claire Mulot, Susan L. Neuhausen, Heli Nevanlinna, Patrick Neven, Sune F. Nielsen, Dong‐Young Noh, Børge G. Nordestgaard, Aaron D. Norman, Olufunmilayo I. Olopade, Janet E. Olson, Håkan Olsson, Curtis Olswold, Nick Orr, V. Shane Pankratz, Sue K. Park, Tjoung‐Won Park‐Simon, Rachel Lloyd, José Ignacio Arias Pérez, Paolo Peterlongo, Julian Peto, Kelly‐Anne Phillips, Mila Pinchev, Dijana Plaseska‐Karanfilska, Ross L. Prentice, Nadège Presneau, Darya Prokofyeva, Elizabeth Pugh, Katri Pylkäs, Brigitte Rack, Paolo Radice, Nazneen Rahman, Gad Rennert, Hedy S. Rennert, Valerie Rhenius, Atocha Romero, Jane Romm, Kathryn J. Ruddy, Thomas Rüdiger, Anja Rudolph, Matthias Ruebner, Emiel J. Rutgers, Emmanouil Saloustros, Dale P. Sandler, Suleeporn Sangrajrang, Elinor J. Sawyer, Daniel F. Schmidt, Rita K. Schmutzler, Andreas Schneeweiß, Minouk J. Schoemaker, Fredrick R. Schumacher, Peter Schürmann, Rodney J. Scott, Christopher G. Scott, Sheila Seal, Caroline Seynaeve, Mitul Shah, Priyanka Sharma, Chen‐Yang Shen, Grace Sheng, Mark E. Sherman, Martha J. Shrubsole, Xiao‐Ou Shu, Ann Smeets, Christof Sohn, Melissa C. Southey, John J. Spinelli, Christa Stegmaier, Sarah Stewart‐Brown, Jennifer Stone, Daniel O. Stram, Harald Surowy, Anthony J. Swerdlow, Rulla M. Tamimi, Jack A. Taylor, Maria Tengström, Soo‐Hwang Teo, Mary Beth Terry,

Association analysis identifies 65 new breast cancer risk loci, predicts target genes for known risk loci and demonstrates a strong overlap with somatic driver genes in breast tumours. Genome-wide association studies for breast cancer have identified common genetic variation that influences susceptibility to this disease, but much of the genetic risk remains unexplained. Doug Easton and colleagues report a genome-wide association study for breast cancer in more than 122,000 cases and 105,000 controls. ...

Nature Portfolio

Lang Wu, Wei Shi, Jirong Long, Xingyi Guo, Kyriaki Michailidou, Jonathan Beesley, Manjeet K. Bolla, Xiao‐Ou Shu, Yingchang Lu, Qiuyin Cai, Fares Al‐Ejeh, Esdy Rozali, Qin Wang, Joe Dennis, Bingshan Li, Chenjie Zeng, Helian Feng, Alexander Gusev, Richard Barfield, Irene L. Andrulis, Hoda Anton‐Culver, Volker Arndt, Kristan J. Aronson, Paul L. Auer, Myrto Barrdahl, Caroline Baynes, Matthias W. Beckmann, Javier Benı́tez, Marina Bermisheva, Carl Blomqvist, Natalia Bogdanova, Stig E. Bojesen, Hiltrud Brauch, Hermann Brenner, Louise A. Brinton, Per Broberg, Sara Y. Brucker, Barbara Burwinkel, Trinidad Caldés, Federico Canzian, Brian D. Carter, Jose E. Castelao, Jenny Chang‐Claude, Xiaohong Chen, Ting‐Yuan David Cheng, Hans Christiansen, Christine L. Clarke, Margriet Collée, Sten Cornelissen, Fergus J. Couch, David G. Cox, Angela Cox, Simon S. Cross, Julie M. Cunningham, Kamila Czene, Mary B. Daly, Peter Devilee, Kimberly F. Doheny, Thilo Dörk, Isabel dos‐Santos‐Silva, Martine Dumont, Miriam Dwek, Diana Eccles, Ursula Eilber, A. Heather Eliassen, Christoph Engel, Mikael Eriksson, Laura Fachal, Peter A. Fasching, Jonine D. Figueroa, Dieter Flesch‐Janys, Olivia Fletcher, Henrik Flyger, Lin Fritschi, Marike Gabrielson, Manuela Gago‐Dominguez, Susan M. Gapstur, Montserrat García‐Closas, Mia M. Gaudet, Maya Ghoussaini, Graham G. Giles, Mark S. Goldberg, David E. Goldgar, Anna González‐Neira, Pascal Guénel, Eric Hahnen, Christopher A. Haiman, Niclas Håkansson, Per Hall, Emily Hallberg, Ute Hamann, Patricia Harrington, Alexander Hein, Belynda Hicks, Peter Hillemanns, Antoinette Hollestelle, Robert N. Hoover, John L. Hopper, Guanmengqian Huang, Keith Humphreys, David J. Hunter, Anna Jakubowska, Wolfgang Janni, Esther M. John, Nichola Johnson, Kristine Jones, Michael E. Jones, Audrey Jung, Rudolf Kaaks, Michael J. Kerin, Э. К. Хуснутдинова, Veli‐Matti Kosma, Vessela N. Kristensen, Diether Lambrechts, Loı̈c Le Marchand, Jingmei Li, Sara Lindström, Jolanta Lissowska, Wing‐Yee Lo, Sibylle Loibl, Jan Lubiński, Craig Luccarini, Michael P. Lux, Robert J. MacInnis, Tom Maishman, Ivana Maleva Kostovska, Graham J. Mann, JoAnn E. Manson, Sara Margolin, Dimitrios Mavroudis, Hanne Meijers‐Heijboer, Thomas Ind, Usha Menon, Jeffery Meyer, Anna Marie Mulligan, Susan L. Neuhausen, Heli Nevanlinna, Patrick Neven, Sune F. Nielsen, Børge G. Nordestgaard, Olufunmilayo I. Olopade, Janet E. Olson, Håkan Olsson, Paolo Peterlongo, Julian Peto, Dijana Plaseska‐Karanfilska, Ross L. Prentice, Nadège Presneau, Katri Pylkäs, Brigitte Rack, Paolo Radice, Nazneen Rahman, Gad Rennert, Hedy S. Rennert, Valerie Rhenius, Atocha Romero, Jane Romm, Anja Rudolph, Emmanouil Saloustros, Dale P. Sandler, Elinor J. Sawyer, Marjanka K. Schmidt, Rita K. Schmutzler, Andreas Schneeweiß, Rodney J. Scott, Christopher G. Scott, Sheila Seal, Mitul Shah, Martha J. Shrubsole, Ann Smeets, Melissa C. Southey, John J. Spinelli, Jennifer Stone, Harald Surowy, Anthony J. Swerdlow, Rulla M. Tamimi, William Tapper, Jack A. Taylor, Mary Beth Terry, Daniel C. Tessier, Abigail Thomas, Kathrin Thöne, Rob A.�E.�M. Tollenaar, Diana Torres, Thérèse Truong, Michael Untch, Celine M. Vachon, David Van Den Berg, Daniel Vincent, Quinten Waisfisz, Clarice R. Weinberg, Camilla Wendt, Alice S. Whittemore, Hans Wildiers, Walter C. Willett, Robert Winqvist, Alicja Wolk, Lucy Xia, Xiaohong R. Yang, Argyrios Ziogas, Elad Ziv, Alison M. Dunning, Paul D.P. Pharoah, Jacques Simard, Roger L. Milne, Stacey L. Edwards, Peter Kraft, Douglas F. Easton, Georgia Chenevix‐Trench, Wei Zheng,

The breast cancer risk variants identified in genome-wide association studies explain only a small fraction of the familial relative risk, and the genes responsible for these associations remain largely unknown. To identify novel risk loci and likely causal genes, we performed a transcriptome-wide association study evaluating associations of genetically predicted gene expression with breast cancer risk in 122,977 cases and 105,974 controls of European ancestry. We used data from the Genotype-Tissue ...

Tópico(s): Bioinformatics and Genomic Networks

2018 - Nature Portfolio | Nature Genetics

Xiang Shu, Lang Wu, Nikhil K. Khankari, Xiao‐Ou Shu, Thomas J. Wang, Kyriaki Michailidou, Manjeet K. Bolla, Qin Wang, Joe Dennis, Roger L. Milne, Marjanka K. Schmidt, Paul D.P. Pharoah, Irene L. Andrulis, David J. Hunter, Jacques Simard, Douglas F. Easton, Wei Zheng, Beeghly-Fadiel Alicia, Hoda Anton‐Culver, Natalia Antonenkova, Volker Arndt, Kristan J. Aronson, Paul L. Auer, Myrto Barrdahl, Caroline Baynes, Laura E. Beane Freeman, Matthias W. Beckmann, Sabine Behrens, Javier Benı́tez, Marina Bermisheva, Carl Blomqvist, Natalia Bogdanova, Stig E. Bojesen, Hiltrud Brauch, Hermann Brenner, Louise A. Brinton, Per Broberg, Sara Y. Brucker, Thomas Brüning, Barbara Burwinkel, Qiuyin Cai, Trinidad Caldés, Federico Canzian, Brian D. Carter, Jose E. Castelao, Jenny Chang‐Claude, Georgia Chenevix‐Trench, Ting‐Yuan David Cheng, Christine L. Clarke, Don Conroy, Fergus J. Couch, David G. Cox, Angela Cox, Simon S. Cross, Julie M. Cunningham, Kamila Czene, Mary B. Daly, Kimberly F. Doheny, Thilo Dörk, Isabel dos‐Santos‐Silva, Martine Dumont, Alison M. Dunning, Miriam Dwek, H. Shelton Earp, Diana Eccles, A. Heather Eliassen, Christoph Engel, Mikael Eriksson, D. Gareth Evans, Laura Fachal, Peter A. Fasching, Jonine D. Figueroa, Olivia Fletcher, Henrik Flyger, Lin Fritschi, Marike Gabrielson, Manuela Gago‐Dominguez, Susan M. Gapstur, Montserrat García‐Closas, Mia M. Gaudet, Maya Ghoussaini, Graham G. Giles, Mark S. Goldberg, David E. Goldgar, Anna González‐Neira, Pascal Guénel, Eric Hahnen, Christopher A. Haiman, Niclas Håkansson, Per Hall, Emily Hallberg, Ute Hamann, Patricia Harrington, Wei He, Alexander Hein, Belynda Hicks, Peter Hillemanns, Frans B.L. Hogervorst, Antoinette Hollestelle, Robert N. Hoover, John L. Hopper, Anthony Howell, Guanmengqian Huang, Anna Jakubowska, Wolfgang Janni, Esther M. John, Nichola Johnson, Kristine Jones, Audrey Jung, Rudolf Kaaks, Maria Kabisch, Michael J. Kerin, Э. К. Хуснутдинова, Cari M. Kitahara, Veli‐Matti Kosma, Stella Koutros, Peter Kraft, Vessela N. Kristensen, Diether Lambrechts, Loı̈c Le Marchand, Sara Lindström, Martha S. Linet, Jolanta Lissowska, Sibylle Loibl, Jan Lubiński, Craig Luccarini, Michael P. Lux, Tom Maishman, Ivana Maleva Kostovska, Graham J. Mann, Siranoush Manoukian, JoAnn E. Manson, Sara Margolin, Dimitrios Mavroudis, Hanne Meijers‐Heijboer, Alfons Meindl, Usha Menon, Jeffery Meyer, Anna Marie Mulligan, Susan L. Neuhausen, Heli Nevanlinna, Patrick Neven, William G. Newman, Sune F. Nielsen, Børge G. Nordestgaard, Olufunmilayo I. Olopade, Andrew F. Olshan, Janet E. Olson, Håkan Olsson, Curtis Olswold, Nick Orr, Charles M. Perou, Julian Peto, Dijana Plaseska-Karanfilska, Ross Prentice, Nadège Presneau, Katri Pylkäs, Brigitte Rack, Paolo Radice, Nazneen Rahman, Gad Rennert, Hedy S. Rennert, Atocha Romero, Jane Romm, Emmanouil Saloustros, Dale P. Sandler, Elinor J. Sawyer, Rita K. Schmutzler, Andreas Schneeweiß, Rodney J. Scott, Christopher G. Scott, Sheila Seal, Caroline Seynaeve, Ann Smeets, Melissa C. Southey, John J. Spinelli, Jennifer Stone, Harald Surowy, Anthony J. Swerdlow, Rulla M. Tamimi, William Tapper, Jack A. Taylor, Mary Beth Terry, Daniel C. Tessier, Kathrin Thöne, Rob A.�E.�M. Tollenaar, Diana Torres, Melissa A. Troester, Thérèse Truong, Michael Untch, Celine M. Vachon, David Van Den Berg, Ans M.W. van den Ouweland, Elke M. van Veen, Daniel Vincent, Quinten Waisfisz, Clarice R. Weinberg, Camilla Wendt, Alice S. Whittemore, Hans Wildiers, Robert Winqvist, Alicja Wolk, Lucy Xia, Xiaohong R. Yang, Argyrios Ziogas, Elad Ziv,

Abstract Background In addition to the established association between general obesity and breast cancer risk, central obesity and circulating fasting insulin and glucose have been linked to the development of this common malignancy. Findings from previous studies, however, have been inconsistent, and the nature of the associations is unclear. Methods We conducted Mendelian randomization analyses to evaluate the association of breast cancer risk, using genetic instruments, with fasting insulin, ...

Tópico(s): Cancer Risks and Factors

2018 - Oxford University Press | International Journal of Epidemiology

Nasim Mavaddat, Kyriaki Michailidou, Joe Dennis, Michael Lush, Laura Fachal, Andrew Lee, Jonathan P. Tyrer, Ting‐Huei Chen, Qin Wang, Manjeet K. Bolla, Xin Yang, Muriel A. Adank, Thomas U. Ahearn, Kristiina Aittomäki, Jamie Allen, Irene L. Andrulis, Hoda Anton‐Culver, Natalia Antonenkova, Volker Arndt, Kristan J. Aronson, Paul L. Auer, Päivi Auvinen, Myrto Barrdahl, Laura E. Beane Freeman, Matthias W. Beckmann, Sabine Behrens, Javier Benı́tez, Marina Bermisheva, Leslie Bernstein, Carl Blomqvist, Natalia Bogdanova, Stig E. Bojesen, Bernardo Bonanni, Anne‐Lise Børresen‐Dale, Hiltrud Brauch, Michael Bremer, Hermann Brenner, Adam R. Brentnall, Ian W. Brock, Angela Brooks‐Wilson, Sara Y. Brucker, Thomas Brüning, Barbara Burwinkel, Daniele Campa, Brian D. Carter, Jose E. Castelao, Stephen J. Chanock, Rowan T. Chlebowski, Hans Christiansen, Christine L. Clarke, J. Margriet Collée, Emilie Cordina‐Duverger, Sten Cornelissen, Fergus J. Couch, Angela Cox, Simon S. Cross, Kamila Czene, Mary B. Daly, Peter Devilee, Thilo Dörk, Isabel dos‐Santos‐Silva, Martine Dumont, Lorraine Durcan, Miriam Dwek, Diana Eccles, Arif B. Ekici, A. Heather Eliassen, Carolina Ellberg, Christoph Engel, Mikael Eriksson, D. Gareth Evans, Peter A. Fasching, Jonine D. Figueroa, Olivia Fletcher, Henrik Flyger, Asta Försti, Lin Fritschi, Marike Gabrielson, Manuela Gago‐Dominguez, Susan M. Gapstur, José Á. García-Sáenz, Mia M. Gaudet, V. Georgoulias, Graham G. Giles, I. R. Gilyazova, Gord Glendon, Mark S. Goldberg, David E. Goldgar, Anna González‐Neira, Grethe I.G. Alnæs, Mervi Grip, Jacek Gronwald, Anne Grundy, Pascal Guénel, Lothar Haeberle, Eric Hahnen, Christopher A. Haiman, Niclas Håkansson, Ute Hamann, Susan E. Hankinson, Elaine F. Harkness, Steven N. Hart, Wei He, Alexander Hein, Jane Heyworth, Peter Hillemanns, Antoinette Hollestelle, Maartje J. Hooning, Robert N. Hoover, John L. Hopper, Anthony Howell, Guanmengqian Huang, Keith Humphreys, David J. Hunter, Milena Jakimovska, Anna Jakubowska, Wolfgang Janni, Esther M. John, Nichola Johnson, Michael E. Jones, Arja Jukkola‐Vuorinen, Audrey Jung, Rudolf Kaaks, Katarzyna Kaczmarek, Vesa Kataja, Renske Keeman, Michael J. Kerin, Э. К. Хуснутдинова, Johanna I. Kiiski, Julia A. Knight, Yon‐Dschun Ko, Veli‐Matti Kosma, Stella Koutros, Vessela N. Kristensen, Ute Krüger, Tabea Kühl, Diether Lambrechts, Loı̈c Le Marchand, Eunjung Lee, Flavio Lejbkowicz, Jenna Lilyquist, Annika Lindblom, Sara Lindström, Jolanta Lissowska, Wing‐Yee Lo, Sibylle Loibl, Jirong Long, Jan Lubiński, Michael P. Lux, Robert J. MacInnis, Tom Maishman, Enes Makalic, Ivana Maleva Kostovska, Graham J. Mann, Siranoush Manoukian, Sara Margolin, John W.M. Martens, Marı́a Elena Martı́nez, Dimitrios Mavroudis, Catriona McLean, Alfons Meindl, Usha Menon, Pooja Middha, Nicola Miller, Fernando Moreno, Anna Marie Mulligan, Claire Mulot, Victor M. Muñoz-Garzon, Susan L. Neuhausen, Heli Nevanlinna, Patrick Neven, William G. Newman, Sune F. Nielsen, Børge G. Nordestgaard, Aaron D. Norman, Kenneth Offit, Janet E. Olson, Håkan Olsson, Nick Orr, V. Shane Pankratz, Tjoung‐Won Park‐Simon, José Ignacio Arias Pérez, Clara Pérez-Barrios, Paolo Peterlongo, Julian Peto, Mila Pinchev, Dijana Plaseska‐Karanfilska, Eric C. Polley, Ross L. Prentice, Nadège Presneau, Darya Prokofyeva, Kristen S. Purrington, Katri Pylkäs, Brigitte Rack, Paolo Radice, Rohini Rau‐Murthy, Gad Rennert, Hedy S. Rennert, Valerie Rhenius, Mark E. Robson, Atocha Romero, Kathryn J. Ruddy, Matthias Ruebner, Emmanouil Saloustros, Dale P. Sandler, Elinor J. Sawyer, Daniel F. Schmidt, Rita K. Schmutzler, Andreas Schneeweiß, Minouk J. Schoemaker, Fredrick R. Schumacher, Peter Schürmann, Lukas Schwentner, Christopher G. Scott, Rodney J. Scott, Caroline Seynaeve, Mitul Shah, Mark E. Sherman, Martha J. Shrubsole, Xiao‐Ou Shu, Susan Slager, Ann Smeets, Christof Sohn, Penny Soucy, Melissa C. Southey, John J. Spinelli, Christa Stegmaier, Jennifer Stone, Anthony J. Swerdlow, Rulla M. Tamimi, William Tapper, Jack A. Taylor, Mary Beth Terry, Kathrin Thöne, Rob A.�E.�M. Tollenaar, Ian Tomlinson, Thérèse Truong, Maria Tzardi, Hans-Ulrich Ulmer, Michael Untch, Celine M. Vachon, Elke M. van Veen, Joseph Vijai, Clarice R. Weinberg, Camilla Wendt, Alice S. Whittemore, Hans Wildiers, Walter C. Willett, Robert Winqvist, Alicja Wolk, Xiaohong R. Yang, Drakoulis Yannoukakos, Yan Zhang, Wei Zheng, Argyrios Ziogas, Alison M. Dunning, Deborah J. Thompson, Georgia Chenevix‐Trench, Jenny Chang‐Claude, Marjanka K. Schmidt, Per Hall, Roger L. Milne, Paul D.P. Pharoah, Antonis C. Antoniou, Nilanjan Chatterjee, Peter Kraft, Montserrat García‐Closas, Jacques Simard, Douglas F. Easton,

Stratification of women according to their risk of breast cancer based on polygenic risk scores (PRSs) could improve screening and prevention strategies. Our aim was to develop PRSs, optimized for prediction of estrogen receptor (ER)-specific disease, from the largest available genome-wide association dataset and to empirically validate the PRSs in prospective studies. The development dataset comprised 94,075 case subjects and 75,017 control subjects of European ancestry from 69 studies, divided into ...

Elsevier BV | The American Journal of Human Genetics

Maria Escala-Garcia, Qi Guo, Thilo Dörk, Sander Canisius, Renske Keeman, Joe Dennis, Jonathan Beesley, Julie Lecarpentier, Manjeet K. Bolla, Qin Wang, Jean Abraham, Irene L. Andrulis, Hoda Anton‐Culver, Volker Arndt, Paul L. Auer, Matthias W. Beckmann, Sabine Behrens, Javier Benı́tez, Marina Bermisheva, Leslie Bernstein, Carl Blomqvist, Bram Boeckx, Stig E. Bojesen, Bernardo Bonanni, Anne‐Lise Børresen‐Dale, Hiltrud Brauch, Hermann Brenner, Adam R. Brentnall, Louise A. Brinton, Per Broberg, Ian W. Brock, Sara Y. Brucker, Barbara Burwinkel, Carlos Caldas, Trinidad Caldés, Daniele Campa, Federico Canzian, Ángel Carracedo, Brian D. Carter, Jose E. Castelao, Jenny Chang‐Claude, Stephen J. Chanock, Georgia Chenevix‐Trench, Ting‐Yuan David Cheng, Suet‐Feung Chin, Christine L. Clarke, Emilie Cordina‐Duverger, Fergus J. Couch, David G. Cox, Angela Cox, Simon S. Cross, Kamila Czene, Mary B. Daly, Peter Devilee, Janet Dunn, Alison M. Dunning, Lorraine Durcan, Miriam Dwek, Helena Earl, Arif B. Ekici, A. Heather Eliassen, Carolina Ellberg, Christoph Engel, Mikael Eriksson, D. Gareth Evans, Jonine D. Figueroa, Dieter Flesch‐Janys, Henrik Flyger, Marike Gabrielson, Manuela Gago‐Dominguez, Eva Galle, Susan M. Gapstur, Montserrat García‐Closas, José Á. García-Sáenz, Mia M. Gaudet, Angela George, V. Georgoulias, Graham G. Giles, Gord Glendon, David E. Goldgar, Anna González‐Neira, Grethe I.G. Alnæs, Mervi Grip, Pascal Guénel, Lothar Haeberle, Eric Hahnen, Christopher A. Haiman, Niclas Håkansson, Per Hall, Ute Hamann, Susan E. Hankinson, Elaine F. Harkness, Patricia Harrington, Steven N. Hart, Jaana M. Hartikainen, Alexander Hein, Peter Hillemanns, Louise Hiller, Bernd Holleczek, Antoinette Hollestelle, Maartje J. Hooning, Robert N. Hoover, John L. Hopper, Anthony Howell, Guanmengqian Huang, Keith Humphreys, David J. Hunter, Wolfgang Janni, Esther M. John, Michael E. Jones, Arja Jukkola‐Vuorinen, Audrey Jung, Rudolf Kaaks, Maria Kabisch, Katarzyna Kaczmarek, Michael J. Kerin, Sofia Khan, Э. К. Хуснутдинова, Johanna I. Kiiski, Cari M. Kitahara, Julia A. Knight, Yon‐Dschun Ko, Linetta B. Koppert, Veli‐Matti Kosma, Peter Kraft, Vessela N. Kristensen, Ute Krüger, Tabea Kühl, Diether Lambrechts, Loı̈c Le Marchand, Eunjung Lee, Flavio Lejbkowicz, Lian Li, Annika Lindblom, Sara Lindström, Martha S. Linet, Jolanta Lissowska, Wing‐Yee Lo, Sibylle Loibl, Jan Lubiński, Michael P. Lux, Robert J. MacInnis, Melanie Maierthaler, Tom Maishman, Enes Makalic, Graham J. Mann, Mehdi Manoochehri, Siranoush Manoukian, Sara Margolin, Marı́a Elena Martı́nez, Dimitrios Mavroudis, Catriona McLean, Alfons Meindl, Pooja Middha, Nicola Miller, Roger L. Milne, Fernando Moreno, Anna Marie Mulligan, Claire Mulot, Rami Nassir, Susan L. Neuhausen, William G. Newman, Sune F. Nielsen, Børge G. Nordestgaard, Aaron D. Norman, Håkan Olsson, Nick Orr, V. Shane Pankratz, Tjoung‐Won Park‐Simon, José Ignacio Arias Pérez, Clara Pérez-Barrios, Paolo Peterlongo, Christos Petridis, Mila Pinchev, K. Prajzendanc, Ross L. Prentice, Nadège Presneau, Darya Prokofieva, Katri Pylkäs, Brigitte Rack, Paolo Radice, Dhanya Ramachandran, Gad Rennert, Hedy S. Rennert, Valerie Rhenius, Atocha Romero, Rebecca Roylance, Emmanouil Saloustros, Elinor J. Sawyer, Daniel F. Schmidt, Rita K. Schmutzler, Andreas Schneeweiß, Minouk J. Schoemaker, Fredrick R. Schumacher, Lukas Schwentner, Rodney J. Scott, Christopher G. Scott, Caroline Seynaeve, Mitul Shah, Jacques Simard, Ann Smeets, Christof Sohn, Melissa C. Southey, Anthony J. Swerdlow, Aline Talhouk, Rulla M. Tamimi, William Tapper, Manuel R. Teixeira, Maria Tengström, Mary Beth Terry, Kathrin Thöne, Rob A.�E.�M. Tollenaar, Ian Tomlinson, Diana Torres, Thérèse Truong, Constance Turman, Clare Turnbull, Hans-Ulrich Ulmer, Michael Untch, Celine M. Vachon, Christi J. van Asperen, Ans M.W. van den Ouweland, Elke M. van Veen, Camilla Wendt, Alice S. Whittemore, Walter C. Willett, Robert Winqvist, Alicja Wolk, Xiaohong R. Yang, Yan Zhang, Douglas F. Easton, Peter A. Fasching, Heli Nevanlinna, Diana Eccles, Paul D.P. Pharoah, Marjanka K. Schmidt,

We examined the associations between germline variants and breast cancer mortality using a large meta-analysis of women of European ancestry. Meta-analyses included summary estimates based on Cox models of twelve datasets using ~10.4 million variants for 96,661 women with breast cancer and 7697 events (breast cancer-specific deaths). Oestrogen receptor (ER)-specific analyses were based on 64,171 ER-positive (4116) and 16,172 ER-negative (2125) patients. We evaluated the probability of a signal to be ...

Tópico(s): Nutrition, Genetics, and Disease

2019 - Springer Nature | British Journal of Cancer

Manuel A. R. Ferreira, Eric R. Gamazon, Fares Al‐Ejeh, Kristiina Aittomäki, Irene L. Andrulis, Hoda Anton‐Culver, Aðalgeir Arason, Volker Arndt, Kristan J. Aronson, Banu K. Arun, Ella Asseryanis, Jacopo Azzollini, Judith Balmañà, Daniel R. Barnes, Daniel Barrowdale, Matthias W. Beckmann, Sabine Behrens, Javier Benı́tez, Marina Bermisheva, Katarzyna Białkowska, Carl Blomqvist, Natalia Bogdanova, Stig E. Bojesen, Manjeet K. Bolla, Åke Borg, Hiltrud Brauch, Hermann Brenner, Annegien Broeks, Barbara Burwinkel, Trinidad Caldés, Maria A. Caligo, Daniele Campa, Ian Campbell, Federico Canzian, Jonathan Carter, Brian D. Carter, Jose E. Castelao, Jenny Chang‐Claude, Stephen J. Chanock, Hans Christiansen, Wendy K. Chung, Kathleen Claes, Christine L. Clarke, Julian Adlard, Munaza Ahmed, Julian Barwell, Angela Brady, Carole Brewer, Jackie Cook, Rosemarie Davidson, Alan C. Donaldson, Jacqueline Eason, Ros Eeles, D. Gareth Evans, Helen Gregory, Helen Hanson, Alex Henderson, Shirley Hodgson, Louise Izatt, Michael J. Kennedy, Fiona Lalloo, Clare M. Miller, Patrick J. Morrison, Kai‐Ren Ong, Jo Perkins, Mary Porteous, Mark T. Rogers, Lucy Side, Katie Snape, Lisa Walker, Patricia A. Harrington, Norbert Arnold, Bernd Auber, Nadja Bogdanova-Markov, Julika Borde, Almuth Caliebe, Nina Ditsch, Bernd Dworniczak, Stefanie Engert, Ulrike Faust, Andrea Gehrig, Eric Hahnen, Jan Hauke, Julia Hentschel, Wei He, Ellen Honisch, Walter Just, Karin Kast, Mirjam Larsen, Johannes Lemke, Huu Phuc Nguyen, Dieter Niederacher, Claus‐Eric Ott, Konrad Platzer, Esther Pohl‐Rescigno, Juliane Ramser, Kerstin Rhiem, Doris Steinemann, Christian Sutter, Raymonda Varon-Mateeva, Shan Wang‐Gohrke, Bernhard H. F. Weber, Fabienne Prieur, Pascal Pujol, Charlotte Sagne, Nicolas Sévenet, Hagay Sobol, Johanna Sokolowska, Dominique Stoppa-Lyonnet, Laurence Venat-Bouvet, Fergus J. Couch, Angela Cox, Simon S. Cross, Kamila Czene, Mary B. Daly, Miguel de la Hoya, Joe Dennis, Peter Devilee, Orland Dı́ez, Thilo Dörk, Alison M. Dunning, Miriam Dwek, Diana Eccles, Bent Ejlertsen, Carolina Ellberg, Christoph Engel, Mikael Eriksson, Peter A. Fasching, Olivia Fletcher, Henrik Flyger, Eitan Friedman, Debra Frost, Marike Gabrielson, Manuela Gago‐Dominguez, Patricia A. Ganz, Susan M. Gapstur, Judy E. Garber, Montserrat García‐Closas, José Á. García-Sáenz, Mia M. Gaudet, Graham G. Giles, Gord Glendon, Andrew K. Godwin, Mark S. Goldberg, David E. Goldgar, Anna González‐Neira, Mark H. Greene, Jacek Gronwald, Pascal Guénel, Christopher A. Haiman, Per Hall, Ute Hamann, Wei He, Jane Heyworth, Manuel R. Teixeira, Antoinette Hollestelle, Robert N. Hoover, John L. Hopper, Peter J. Hulick, Keith Humphreys, Evgeny N. Imyanitov, Rosemary Balleine, Robert Baxter, Stephen Braye, Jane Carpenter, Jane E. Dahlstrom, John Forbes, Shin-Ru Lee, Deborah J. Marsh, Adrienne Morey, Nirmala Pathmanathan, Peter Simpson, Allan D. Spigelman, Nicholas Wilcken, Desmond Yip, Bernadette A. M. Heemskerk‐Gerritsen, Matti A. Rookus, Caroline Seynaeve, Frederieke H. van der Baan, Annemieke H. van der Hout, Lizet E. van der Kolk, Rob B. van der Luijt, Carolien H. M. van Deurzen, Helena C. van Doorn, Klaartje van Engelen, Liselotte van Hest, Theo A.M. van Os, Senno Verhoef, Maartje J. Vogel, Juul Wijnen, Alexander Miron, Miroslav Kapuscinski, Anita Bane, Eric A. Ross, Saundra S. Buys, Thomas Conner, Claudine Isaacs, Milena Jakimovska, Anna Jakubowska, Paul A. James, Ramunas Janavicius, Rachel C. Jankowitz, Esther M. John, Nichola Johnson, Joseph Vijai, Beth Y. Karlan, Э. К. Хуснутдинова, Johanna I. Kiiski, Yon‐Dschun Ko, Michael E. Jones, Irene Konstantopoulou, Vessela N. Kristensen, Yael Laitman, Diether Lambrechts, Conxi Lázaro, Goska Leslie, Jenny Lester, Fabienne Lesueur, Sara Lindström, Jirong Long, Jennifer T. Loud, Jan Lubiński, Enes Makalic, Graham J. Mann, Mehdi Manoochehri, Sara Margolin, Tabea Maurer, Dimitrios Mavroudis, Lesley McGuffog, Alfons Meindl, Usha Menon, Kyriaki Michailidou, Austin Miller, Marco Montagna, Fernando Moreno, Lidia Moserle, Anna Marie Mulligan, Katherine L. Nathanson, Susan L. Neuhausen, Heli Nevanlinna, Ines Nevelsteen, Finn C. Nielsen, Liene Ņikitina-Zaķe, Robert L. Nussbaum, Kenneth Offit, Edith Olah, Olufunmilayo I. Olopade, Håkan Olsson, Ana Osório, J. Papp, Tjoung-Won Park-Simon, Michael T. Parsons, Inge Søkilde Pedersen, Ana Peixoto, Paolo Peterlongo, Paul D.P. Pharoah, Dijana Plaseska-Karanfilska, Bruce Poppe, Nadège Presneau, Paolo Radice, Johanna Rantala, Gad Rennert, Harvey A. Risch, Emmanouil Saloustros, Kristin Sanden, Elinor J. Sawyer, Marjanka K. Schmidt, Rita K. Schmutzler, Priyanka Sharma, Xiao-Ou Shu, Jacques Simard, Christian F. Singer, Penny Soucy, Melissa C. Southey, John J. Spinelli, Amanda B. Spurdle, Jennifer Stone, Anthony J. Swerdlow, William Tapper, Jack A. Taylor, Manuel R. Teixeira, Mary Beth Terry, Àlex Teulé, Mads Thomassen, Kathrin Thöne, Darcy L. Thull, Marc Tischkowitz, Amanda E. Toland, Diana Torres, Thérèse Truong, Nadine Tung, Celine M. Vachon, Christi J. van Asperen, Ans M.W. van den Ouweland, Elizabeth J. van Rensburg, Ana Vega,

Abstract Genome-wide association studies (GWAS) have identified more than 170 breast cancer susceptibility loci. Here we hypothesize that some risk-associated variants might act in non-breast tissues, specifically adipose tissue and immune cells from blood and spleen. Using expression quantitative trait loci (eQTL) reported in these tissues, we identify 26 previously unreported, likely target genes of overall breast cancer risk variants, and 17 for estrogen receptor (ER)-negative breast cancer, several ...

Nature Portfolio

Haoyu Zhang, Thomas U. Ahearn, Julie Lecarpentier, Daniel R. Barnes, Jonathan Beesley, Guanghao Qi, Xia Jiang, Tracy A. O’Mara, Ni Zhao, Manjeet K. Bolla, Alison M. Dunning, Joe Dennis, Qin Wang, Zumuruda Abu Ful, Kristiina Aittomäki, Irene L. Andrulis, Hoda Anton‐Culver, Volker Arndt, Kristan J. Aronson, Banu K. Arun, Paul L. Auer, Jacopo Azzollini, Daniel Barrowdale, Heiko Becher, Matthias W. Beckmann, Sabine Behrens, Javier Benı́tez, Marina Bermisheva, Katarzyna Białkowska, Ana Blanco, Carl Blomqvist, Natalia Bogdanova, Stig E. Bojesen, Bernardo Bonanni, Davide Bondavalli, Åke Borg, Hiltrud Brauch, Hermann Brenner, Ignacio Briceño, Annegien Broeks, Sara Y. Brucker, Thomas Brüning, Barbara Burwinkel, Saundra S. Buys, Helen Byers, Trinidad Caldés, Maria A. Caligo, Mariarosaria Calvello, Daniele Campa, Jose E. Castelao, Jenny Chang‐Claude, Stephen J. Chanock, Melissa Christiaens, Hans Christiansen, Wendy K. Chung, Kathleen Claes, Christine L. Clarke, Sten Cornelissen, Fergus J. Couch, Angela Cox, Simon S. Cross, Kamila Czene, Mary B. Daly, Peter Devilee, Orland Dı́ez, Susan M. Domchek, Thilo Dörk, Miriam Dwek, Diana Eccles, Arif B. Ekici, D. Gareth Evans, Peter A. Fasching, Jonine D. Figueroa, Lenka Foretová, Florentia Fostira, Eitan Friedman, Debra Frost, Manuela Gago‐Dominguez, Susan M. Gapstur, Judy E. Garber, José Á. García-Sáenz, Mia M. Gaudet, Simon A. Gayther, Graham G. Giles, Andrew K. Godwin, Mark S. Goldberg, David E. Goldgar, Anna González‐Neira, Mark H. Greene, Jacek Gronwald, Pascal Guénel, Lothar Häberle, Eric Hahnen, Christopher A. Haiman, Christopher R. Hake, Per Hall, Ute Hamann, Elaine F. Harkness, Bernadette A. M. Heemskerk‐Gerritsen, Peter Hillemanns, Frans B.L. Hogervorst, Bernd Holleczek, Antoinette Hollestelle, Maartje J. Hooning, Robert N. Hoover, John L. Hopper, Anthony Howell, Hanna Huebner, Peter J. Hulick, Evgeny N. Imyanitov, Claudine Isaacs, Louise Izatt, Agnes Jager, Milena Jakimovska, Anna Jakubowska, Paul A. James, Ramunas Janavicius, Wolfgang Janni, Esther M. John, Michael E. Jones, Audrey Jung, Rudolf Kaaks, Pooja Middha, Beth Y. Karlan, Renske Keeman, Sofia Khan, Э. К. Хуснутдинова, Cari M. Kitahara, Yon‐Dschun Ko, Irene Konstantopoulou, Linetta B. Koppert, Stella Koutros, Vessela N. Kristensen, Anne‐Vibeke Lænkholm, Diether Lambrechts, Susanna C. Larsson, Pierre Laurent‐Puig, Conxi Lázaro, Emilija Lazarova, Flavio Lejbkowicz, Goska Leslie, Fabienne Lesueur, Annika Lindblom, Jolanta Lissowska, Wing‐Yee Lo, Jennifer T. Loud, Jan Lubiński, Alicja Łukomska, Robert J. MacInnis, Graham J. Mann, Mehdi Manoochehri, Siranoush Manoukian, Sara Margolin, Marı́a Elena Martı́nez, Laura Matricardi, Lesley McGuffog, Catriona McLean, Noura Mebirouk, Alfons Meindl, Usha Menon, Austin Miller, Elvira Mingazheva, Marco Montagna, Anna Marie Mulligan, Claire Mulot, Taru Muranen, Katherine L. Nathanson, Susan L. Neuhausen, Heli Nevanlinna, Patrick Neven, William G. Newman, Finn Cilius Nielsen, Liene Ņikitina-Zaķe, Jesse Nodora, Kenneth Offit, Edith Oláh, Olufunmilayo I. Olopade, Håkan Olsson, Nick Orr, Laura Papi, J. Papp, Tjoung‐Won Park‐Simon, Michael T. Parsons, Bernard Peissel, Ana Peixoto, Beth N. Peshkin, Paolo Peterlongo, Julian Peto, Kelly‐Anne Phillips, Marion Piedmonte, Dijana Plaseska‐Karanfilska, Karolina Prajzendanc, Ross Prentice, Darya Prokofyeva, Brigitte Rack, Paolo Radice, Susan J. Ramus, Johanna Rantala, Muhammad Usman Rashid, Gad Rennert, Hedy S. Rennert, Harvey A. Risch, Atocha Romero, Matti A. Rookus, Matthias Rübner, Thomas Rüdiger, Emmanouil Saloustros, Sarah Sampson, Dale P. Sandler, Elinor J. Sawyer, Maren T. Scheuner, Rita K. Schmutzler, Andreas Schneeweiß, Minouk J. Schoemaker, Ben Schöttker, Peter Schürmann, Leigha Senter, Priyanka Sharma, Mark E. Sherman, Xiao-Ou Shu, Christian F. Singer, Snezhana Smichkoska, Penny Soucy, Melissa C. Southey, John J. Spinelli, Jennifer Stone, Dominique Stoppa‐Lyonnet, Anthony J. Swerdlow, Csilla I. Szabo, Rulla M. Tamimi, William Tapper, Jack A. Taylor, Manuel R. Teixeira, Mary Beth Terry, Mads Thomassen, Darcy L. Thull, Marc Tischkowitz, Amanda E. Toland, Rob A.�E.�M. Tollenaar, Ian Tomlinson, Diana Torres, Melissa A. Troester, Thérèse Truong, Nadine Tung, Michael Untch, Celine M. Vachon, Ans M.W. van den Ouweland, Lizet E. van der Kolk, Elke M. van Veen, Elizabeth J. vanRensburg, Ana Vega, Barbara Wappenschmidt, Clarice R. Weinberg, Jeffrey N. Weitzel, Hans Wildiers, Robert Winqvist, Alicja Wolk, Xiaohong R. Yang, Drakoulis Yannoukakos, Wei Zheng, Kristin K. Zorn, Roger L. Milne, Peter Kraft, Jacques Simard, Paul D.P. Pharoah, Kyriaki Michailidou, Antonis C. Antoniou, Marjanka K. Schmidt, Georgia Chenevix‐Trench, Douglas F. Easton, Nilanjan Chatterjee, Montserrat García‐Closas,

Breast cancer susceptibility variants frequently show heterogeneity in associations by tumor subtype1–3. To identify novel loci, we performed a genome-wide association study including 133,384 breast cancer cases and 113,789 controls, plus 18,908 BRCA1 mutation carriers (9,414 with breast cancer) of European ancestry, using both standard and novel methodologies that account for underlying tumor heterogeneity by estrogen receptor, progesterone receptor and human epidermal growth factor receptor 2 status ...

Tópico(s): BRCA gene mutations in cancer

Nature Portfolio | Nature Genetics

Suzanne C. Dixon‐Suen, Sarah J. Lewis, Richard M. Martin, Dallas R. English, Terry Boyle, Graham G. Giles, Kyriaki Michailidou, Manjeet K. Bolla, Qin Wang, Joe Dennis, Michael Lush, ABCTB Investigators, Thomas U. Ahearn, Christine B. Ambrosone, Irene L. Andrulis, Hoda Anton‐Culver, Volker Arndt, Kristan J. Aronson, Annelie Augustinsson, Päivi Auvinen, Laura E. Beane Freeman, Heiko Becher, Matthias W. Beckmann, Sabine Behrens, Marina Bermisheva, Carl Blomqvist, Natalia Bogdanova, Stig E. Bojesen, Bernardo Bonanni, Hermann Brenner, Thomas Brüning, Saundra S. Buys, Nicola J. Camp, Daniele Campa, Federico Canzian, Jose E. Castelao, Melissa H. Cessna, Jenny Chang‐Claude, Stephen J. Chanock, Christine L. Clarke, Don Conroy, Fergus J. Couch, Angela Cox, Simon S. Cross, Kamila Czene, Mary B. Daly, Peter Devilee, Thilo Dörk, Miriam Dwek, Diana Eccles, A. Heather Eliassen, Christoph Engel, Mikael Eriksson, D. Gareth Evans, Peter A. Fasching, Olivia Fletcher, Henrik Flyger, Lin Fritschi, Marike Gabrielson, Manuela Gago‐Dominguez, Montserrat García‐Closas, José Á. García-Sáenz, Mark S. Goldberg, Pascal Guénel, Melanie Gündert, Eric Hahnen, Christopher A. Haiman, Lothar Häberle, Niclas Håkansson, Per Hall, Ute Hamann, Steven N. Hart, Michelle Harvie, Peter Hillemanns, Antoinette Hollestelle, Maartje J. Hooning, Reiner Hoppe, John L. Hopper, Anthony Howell, David J. Hunter, Anna Jakubowska, Wolfgang Janni, Esther M. John, Audrey Jung, Rudolf Kaaks, Renske Keeman, Cari M. Kitahara, Stella Koutros, Peter Kraft, Vessela N. Kristensen, Katerina Kubelka‐Sabit, Allison W. Kurian, James V. Lacey, Diether Lambrechts, Loı̈c Le Marchand, Annika Lindblom, Sibylle Loibl, Jan Lubiński, Arto Mannermaa, Mehdi Manoochehri, Sara Margolin, Marı́a Elena Martı́nez, Dimitrios Mavroudis, Usha Menon, Anna Marie Mulligan, Rachel A. Murphy, NBCS Collaborators, Heli Nevanlinna, Ines Nevelsteen, William G. Newman, Kenneth Offit, Andrew F. Olshan, Håkan Olsson, Nick Orr, Alpa V. Patel, Julian Peto, Dijana Plaseska‐Karanfilska, Nadège Presneau, Brigitte Rack, Paolo Radice, Erika Rees‐Punia, Gad Rennert, Hedy S. Rennert, Atocha Romero, Emmanouil Saloustros, Dale P. Sandler, Marjanka K. Schmidt, Rita K. Schmutzler, Lukas Schwentner, Christopher J. Scott, Mitul Shah, Xiao‐Ou Shu, Jacques Simard, Melissa C. Southey, Jennifer Stone, Harald Surowy, Anthony J. Swerdlow, Rulla M. Tamimi, William Tapper, Jack A. Taylor, Mary Beth Terry, Rob A.�E.�M. Tollenaar, Melissa A. Troester, Thérèse Truong, Michael Untch, Celine M. Vachon, Joseph Vijai, Barbara Wappenschmidt, Clarice R. Weinberg, Alicja Wolk, Drakoulis Yannoukakos, Wei Zheng, Argyrios Ziogas, Alison M. Dunning, Paul D.P. Pharoah, Douglas F. Easton, Roger L. Milne, Brigid M. Lynch,

Physical inactivity and sedentary behaviour are associated with higher breast cancer risk in observational studies, but ascribing causality is difficult. Mendelian randomisation (MR) assesses causality by simulating randomised trial groups using genotype. We assessed whether lifelong physical activity or sedentary time, assessed using genotype, may be causally associated with breast cancer risk overall, pre/post-menopause, and by case-groups defined by tumour characteristics.

Tópico(s): Nutritional Studies and Diet

2022 - BMJ | British Journal of Sports Medicine

Nasim Mavaddat, Leila Dorling, Sara Carvalho, Jamie Allen, Anna González‐Neira, Renske Keeman, Manjeet K. Bolla, Joe Dennis, Qin Wang, Thomas U. Ahearn, Irene L. Andrulis, Matthias W. Beckmann, Sabine Behrens, Javier Benı́tez, Marina Bermisheva, Carl Blomqvist, Natalia Bogdanova, Stig E. Bojesen, Ignacio Briceño, Thomas Brüning, Nicola J. Camp, Archie Campbell, Jose E. Castelao, Jenny Chang‐Claude, Stephen J. Chanock, Georgia Chenevix‐Trench, Hans Christiansen, Kamila Czene, Thilo Dörk, Mikael Eriksson, D. Gareth Evans, Peter A. Fasching, Jonine D. Figueroa, Henrik Flyger, Marike Gabrielson, Manuela Gago‐Dominguez, Jürgen Geisler, Graham G. Giles, Pascal Guénel, Andreas Hadjisavvas, Eric Hahnen, Per Hall, Ute Hamann, Jaana M. Hartikainen, Mikael Hartman, Reiner Hoppe, Sacha J. Howell, Anna Jakubowska, Audrey Jung, Э. К. Хуснутдинова, Vessela N. Kristensen, Jingmei Li, Swee Ho Lim, Annika Lindblom, Maria A. Loizidou, Artitaya Lophatananon, Jan Lubiński, Michael J. Madsen, Graham J. Mann, Mehdi Manoochehri, Sara Margolin, Dimitrios Mavroudis, Roger L. Milne, Nur Aishah Mohd Taib, Anna Morra, Kenneth Muir, Nadia Obi, Ana Osório, Tjoung‐Won Park‐Simon, Paolo Peterlongo, Paolo Radice, Emmanouil Saloustros, Elinor J. Sawyer, Rita K. Schmutzler, Mitul Shah, Xueling Sim, Melissa C. Southey, Heather Thorne, Ian Tomlinson, Diana Torres, Thérèse Truong, Cheng Har Yip, Amanda B. Spurdle, Maaike P.G. Vreeswijk, Alison M. Dunning, Montserrat García‐Closas, Paul D.P. Pharoah, Anders Kvist, Taru Muranen, Heli Nevanlinna, Soo‐Hwang Teo, Peter Devilee, Marjanka K. Schmidt, Douglas F. Easton,

Rare germline genetic variants in several genes are associated with increased breast cancer (BC) risk, but their precise contributions to different disease subtypes are unclear. This information is relevant to guidelines for gene panel testing and risk prediction.To characterize tumors associated with BC susceptibility genes in large-scale population- or hospital-based studies.The multicenter, international case-control analysis of the BRIDGES study included 42 680 patients and 46 387 control participants, ...

Tópico(s): Cancer Genomics and Diagnostics

2022 - American Medical Association | JAMA Oncology

Xiang Jiao, Christos Aravidis, Rajeshwari Marikkannu, Johanna Rantala, Simone Picelli, Tatjana Adamović, Tao Liu, Paula Maguire, Bárbara Kremeyer, Liping Luo, Susanna von Holst, Vinaykumar Kontham, Jessada Thutkawkorapin, Sara Margolin, Quan Du, Johanna Lundin, Kyriaki Michailidou, Manjeet K. Bolla, Qin Wang, Joe Dennis, Michael Lush, Christine B. Ambrosone, Irene L. Andrulis, Hoda Anton‐Culver, Natalia Antonenkova, Volker Arndt, Matthias W. Beckmann, Carl Blomqvist, William J. Blot, Bram Boeckx, Stig E. Bojesen, Bernardo Bonanni, Judith S. Brand, Hiltrud Brauch, Hermann Brenner, Annegien Broeks, Thomas Brüning, Barbara Burwinkel, Qiuyin Cai, Jenny Chang‐Claude, Fergus J. Couch, Angela Cox, Simon S. Cross, Sandra Deming-Halverson, Peter Devilee, Isabel dos‐Santos‐Silva, Thilo Dörk, Mikael Eriksson, Peter A. Fasching, Jonine D. Figueroa, Dieter Flesch‐Janys, Henrik Flyger, Marike Gabrielson, Montserrat García‐Closas, Graham G. Giles, Anna González‐Neira, Pascal Guénel, Qi Guo, Melanie Gündert, Christopher A. Haiman, Emily Hallberg, Ute Hamann, Patricia Harrington, Maartje J. Hooning, John L. Hopper, Guanmengqian Huang, Anna Jakubowska, Michael E. Jones, Michael J. Kerin, Veli‐Matti Kosma, Vessela N. Kristensen, Diether Lambrechts, Loı̈c Le Marchand, Jan Lubiński, Graham J. Mann, John W.M. Martens, Thomas Ind, Roger L. Milne, Anna Marie Mulligan, Susan L. Neuhausen, Heli Nevanlinna, Julian Peto, Katri Pylkäs, Paolo Radice, Valerie Rhenius, Elinor J. Sawyer, Marjanka K. Schmidt, Rita K. Schmutzler, Caroline Seynaeve, Mitul Shah, Jacques Simard, Melissa C. Southey, Anthony J. Swerdlow, Thérèse Truong, Camilla Wendt, Robert Winqvist, Wei Zheng, Javier Benı́tez, Alison M. Dunning, Paul D.P. Pharoah, Douglas F. Easton, Kamila Czene, Per Hall, Annika Lindblom,

... Volker Arndt 11 , Matthias W. Beckmann 12 , Carl Blomqvist 13 , William Blot 14,15 , Bram Boeckx 16,17 , Stig E. Bojesen 18,19,20 , Bernardo Bonanni 21 , ...

Tópico(s): BRCA gene mutations in cancer

2017 - Impact Journals LLC | Oncotarget

Stefanie H. Mueller, Alvina G. Lai, Maria Valkovskaya, Kyriaki Michailidou, Manjeet K. Bolla, Qin Wang, Joe Dennis, Michael Lush, Zomoruda Abu-Ful, Thomas U. Ahearn, Irene L. Andrulis, Hoda Anton‐Culver, Natalia Antonenkova, Volker Arndt, Kristan J. Aronson, Annelie Augustinsson, Thaïs Baert, Laura E. Beane Freeman, Matthias W. Beckmann, Sabine Behrens, Javier Benı́tez, Marina Bermisheva, Carl Blomqvist, Natalia Bogdanova, Stig E. Bojesen, Bernardo Bonanni, Hermann Brenner, Sara Y. Brucker, Saundra S. Buys, Jose E. Castelao, Tsun Leung Chan, Jenny Chang‐Claude, Stephen J. Chanock, Ji‐Yeob Choi, Wendy K. Chung, Kristine Kleivi Sahlberg, Anne‐Lise Børresen‐Dale, Lars Ottestad, Rolf Kåresen, Ellen Schlichting, Marit Muri Holmen, Toril Sauer, Vilde Drageset Haakensen, Olav Engebråten, Bjørn Naume, Alexander Fosså, Cecile E. Kiserud, Kristin V. Reinertsen, Åslaug Helland, Margit Riis, Jürgen Geisler, Grethe I.G. Alnæs, Sarah V. Colonna, Sten Cornelissen, Fergus J. Couch, Kamila Czene, Mary B. Daly, Peter Devilee, Thilo Dörk, Laure Dossus, Miriam Dwek, Diana Eccles, Arif B. Ekici, A. Heather Eliassen, Christoph Engel, D. Gareth Evans, Peter A. Fasching, Olivia Fletcher, Henrik Flyger, Manuela Gago‐Dominguez, Yu-Tang Gao, Montserrat García‐Closas, José A. García-Sáenz, Jeanine M. Genkinger, Aleksandra Gentry-Maharaj, Felix Graßmann, Pascal Guénel, Melanie Gündert, Lothar Haeberle, Eric Hahnen, Christopher A. Haiman, Niclas Håkansson, Per Hall, Elaine F. Harkness, Patricia A. Harrington, Jaana M. Hartikainen, Mikael Hartman, Alexander Hein, Weang-Kee Ho, Maartje J. Hooning, Reiner Hoppe, John L. Hopper, Richard S. Houlston, Anthony Howell, David J. Hunter, Dezheng Huo, Deborah J. Marsh, Rodney J. Scott, Robert Baxter, Desmond Yip, Jane Carpenter, Alison Davis, Nirmala Pathmanathan, Peter T. Simpson, J. Dinny Graham, Mythily Sachchithananthan, Hidemi Ito, Motoki Iwasaki, Anna Jakubowska, Wolfgang Janni, Esther M. John, Michael E. Jones, Audrey Jung, Rudolf Kaaks, Daehee Kang, Elza K. Khusnutdinova, Sung-Won Kim, Cari M. Kitahara, Stella Koutros, Peter Kraft, Vessela N. Kristensen, Katerina Kubelka‐Sabit, Allison W. Kurian, Ava Kwong, James V. Lacey, Diether Lambrechts, Loic Le Marchand, Jingmei Li, Martha S. Linet, Wing‐Yee Lo, Jirong Long, Artitaya Lophatananon, Arto Mannermaa, Mehdi Manoochehri, Sara Margolin, Keitaro Matsuo, Dimitrios Mavroudis, Usha Menon, Kenneth Muir, Rachel A. Murphy, Heli Nevanlinna, William G. Newman, Dieter Niederacher, Katie M. O’Brien, Nadia Obi, Kenneth Offit, Olufunmilayo I. Olopade, Andrew F. Olshan, Håkan Olsson, Sue K. Park, Alpa V. Patel, Achal Patel, Charles M. Perou, Julian Peto, Paul D.P. Pharoah, Dijana Plaseska‐Karanfilska, Nadège Presneau, Brigitte Rack, Paolo Radice, Dhanya Ramachandran, Muhammad Usman Rashid, Gad Rennert, Atocha Romero, Kathryn J. Ruddy, Matthias Ruebner, Emmanouil Saloustros, Dale P. Sandler, Elinor J. Sawyer, Marjanka K. Schmidt, Rita K. Schmutzler, Michael Schneider, Christopher J. Scott, Mitul Shah, Priyanka Sharma, Chen‐Yang Shen, Xiao-Ou Shu, Jacques Simard, Harald Surowy, Rulla M. Tamimi, William Tapper, Jack A. Taylor, Soo‐Hwang Teo, Lauren Teras, Amanda E. Toland, Rob A.�E.�M. Tollenaar, Diana Torres, Gabriela Torres-Mejía, Melissa A. Troester, Thérèse Truong, Celine M. Vachon, Joseph Vijai, Clarice R. Weinberg, Camilla Wendt, Robert Winqvist, Alicja Wolk, Anna H. Wu, Taiki Yamaji, Xiaohong R. Yang, Jyh-Cherng Yu, Wei Zheng, Argyrios Ziogas, Elad Ziv, Alison M. Dunning, Douglas F. Easton, Harry Hemingway, U. Hamann, Karoline Kuchenbaecker,

Low-frequency variants play an important role in breast cancer (BC) susceptibility. Gene-based methods can increase power by combining multiple variants in the same gene and help identify target genes.

Tópico(s): Genomic variations and chromosomal abnormalities

2023 - BioMed Central | Genome Medicine

Juho Konsti, Mikael Lundin, Nina Linder, Caj Haglund, Carl Blomqvist, Heli Nevanlinna, Kirsimari Aaltonen, Stig Nordling, Johan Lundin,

Digital whole-slide scanning of tissue specimens produces large images demanding increasing storing capacity. To reduce the need of extensive data storage systems image files can be compressed and scaled down. The aim of this article is to study the effect of different levels of image compression and scaling on automated image analysis of immunohistochemical (IHC) stainings and automated tumor segmentation. Two tissue microarray (TMA) slides containing 800 samples of breast cancer tissue immunostained ...

Tópico(s): Cell Image Analysis Techniques

2012 - BioMed Central | Diagnostic Pathology

Felix R. Day, Katherine S. Ruth, Deborah J. Thompson, Kathryn L. Lunetta, Natalia Pervjakova, Daniel I. Chasman, Lisette Stolk, Hilary K. Finucane, Patrick Sulem, Brendan Bulik‐Sullivan, Tõnu Esko, Andrew D. Johnson, Cathy E. Elks, Nora Franceschini, Chunyan He, Elisabeth Altmaier, Jennifer A. Brody, Lude Franke, Jennifer E. Huffman, Margaux F. Keller, Patrick F. McArdle, Teresa Nutile, Eleonora Porcu, Antonietta Robino, Lynda M. Rose, Ursula M. Schick, Jennifer A. Smith, Alexander Teumer, Michela Traglia, Dragana Vuckovic, Jie Yao, Wei Zhao, Eva Albrecht, Najaf Amin, Tanguy Corre, Jouke‐Jan Hottenga, Massimo Mangino, Albert V. Smith, Toshiko Tanaka, Gonçalo R. Abecasis, Irene L. Andrulis, Hoda Anton‐Culver, Antonis C. Antoniou, Volker Arndt, Alice M. Arnold, Caterina Barbieri, Matthias W. Beckmann, Alicia Beeghly‐Fadiel, Javier Benı́tez, Leslie Bernstein, Suzette J. Bielinski, Carl Blomqvist, Eric Boerwinkle, Natalia Bogdanova, Stig E. Bojesen, Manjeet K. Bolla, Anne‐Lise Børresen‐Dale, Thibaud Boutin, Hiltrud Brauch, Hermann Brenner, Thomas Brüning, Barbara Burwinkel, Archie Campbell, Harry Campbell, Stephen J. Chanock, J. Ross Chapman, Yii-Der Ida Chen, Georgia Chenevix‐Trench, Fergus J. Couch, Andrea D. Coviello, Angela Cox, Kamila Czene, Hatef Darabi, Immaculata De Vivo, Ellen W. Demerath, Joe Dennis, Peter Devilee, Thilo Dörk, Isabel dos‐Santos‐Silva, Alison M. Dunning, John D. Eicher, Peter A. Fasching, Jessica D. Faul, Jonine D. Figueroa, Dieter Flesch‐Janys, Ilaria Gandin, Melissa E. Garcia, Montserrat García‐Closas, Graham G. Giles, Giorgia Girotto, Mark S. Goldberg, Anna González‐Neira, Mark O. Goodarzi, Megan L. Grove, Daníel F. Guðbjartsson, Pascal Guénel, Xiuqing Guo, Christopher A. Haiman, Per Hall, Ute Hamann, Brian E. Henderson, Lynne J. Hocking, Albert Hofman, Georg Homuth, Maartje J. Hooning, John L. Hopper, Frank B. Hu, Jinyan Huang, Keith Humphreys, David J. Hunter, Anna Jakubowska, Samuel E. Jones, Maria Kabisch, David Karasik, Julia A. Knight, Ivana Kolčić, Charles Kooperberg, Veli‐Matti Kosma, Jennifer Kriebel, Vessela N. Kristensen, Diether Lambrechts, Claudia Langenberg, Jingmei Li, Xin Li, Sara Lindström, Yongmei Liu, Jian’an Luan, Jan Lubiński, Reedik Mägi, Graham J. Mann, Judith Manz, Sara Margolin, Jonathan Marten, Nicholas G. Martin, Corrado Masciullo, Alfons Meindl, Kyriaki Michailidou, Evelin Mihailov, Lili Milani, Roger L. Milne, Martina Müller‐Nurasyid, Michael A. Nalls, Ben Neale, Heli Nevanlinna, Patrick Neven, Anne B. Newman, Børge G. Nordestgaard, Janet E. Olson, Sandosh Padmanabhan, Paolo Peterlongo, Ulrike Peters, Astrid Petersmann, Julian Peto, Paul D.P. Pharoah, Nicola Pirastu, Ailith Pirie, Giorgio Pistis, Ozren Polašek, David J. Porteous, Bruce M. Psaty, Katri Pylkäs, Paolo Radice, Leslie J. Raffel, Fernando Rivadeneira, Igor Rudan, Anja Rudolph, Daniela Ruggiero, Cinzia Sala, Serena Sanna, Elinor J. Sawyer, David Schlessinger, Marjanka K. Schmidt, Frank Schmidt, Rita K. Schmutzler, Minouk J. Schoemaker, Robert A. Scott, Caroline Seynaeve, Jacques Simard, Rossella Sorice, Melissa C. Southey, Doris Stöckl, Konstantin Strauch, Anthony J. Swerdlow, Kent D. Taylor, Unnur Þorsteinsdóttir, Amanda E. Toland, Ian M. Tomlinson, Thérèse Truong, Laufey Tryggvadóttír, Stephen T. Turner, Diego Vozzi, Qin Wang, Melissa Wellons, Gonneke Willemsen, James F. Wilson, Robert Winqvist, Bruce H. R. Wolffenbuttel, Alan F. Wright, Drakoulis Yannoukakos, Tatijana Zemunik, Wei Zheng, Marek Zygmunt, Sven Bergmann, Dorret I. Boomsma, Julie E. Buring, Luigi Ferrucci, Grant W. Montgomery, Vilmundur Guðnason, Tim D. Spector, Cornelia M. van Duijn, Behrooz Z. Alizadeh, Marina Ciullo, Laura Crisponi, Douglas F. Easton, Paolo Gasparini, Christian Gieger, Tamara B. Harris, Caroline Hayward, Sharon L. R. Kardia, Peter Kraft, Barbara McKnight, Andres Metspalu, Alanna C. Morrison, Alex P. Reiner, Paul M. Ridker, Jerome I. Rotter, Daniela Toniolo, André G. Uitterlinden, Sheila Ulivi, Henry Völzke, Nicholas J. Wareham, David R. Weir, Laura M. Yerges-Armstrong, Alkes L. Price, Kári Stéfansson, Jenny A. Visser, Ken K. Ong, Jenny Chang‐Claude, Joanne M. Murabito, John R. B. Perry, Anna Murray,

John Perry and colleagues report the results of a large genome-wide association study meta-analysis to identify variants influencing age at natural menopause. They identify 54 independent signals and find enrichment near genes involved in delayed puberty and DNA damage response. Menopause timing has a substantial impact on infertility and risk of disease, including breast cancer, but the underlying mechanisms are poorly understood. We report a dual strategy in ∼70,000 women to identify common and ...

Tópico(s): Nutrition, Genetics, and Disease

2015 - Nature Portfolio | Nature Genetics

Antoinette Hollestelle, Frederieke H. van der Baan, Andrew Berchuck, Sharon E. Johnatty, Katja K.H. Aben, Bjarni A. Agnarsson, Kristiina Aittomäki, Elisa Alducci, Irene L. Andrulis, Hoda Anton‐Culver, Natalia Antonenkova, Antonis C. Antoniou, Carmel Apicella, Volker Arndt, Norbert Arnold, Banu K. Arun, Brita Arver, Alan Ashworth, Laura Baglietto, Rosemary L. Balleine, Elisa V. Bandera, Daniel Barrowdale, Yukie T. Bean, Lars Beckmann, Matthias W. Beckmann, Javier Benı́tez, Andreas Berger, Raanan Berger, Benoit Beuselinck, Maria Bisogna, Line Bjørge, Carl Blomqvist, Natalia Bogdanova, Anders Bojesen, Stig E. Bojesen, Manjeet K. Bolla, Bernardo Bonanni, Judith S. Brand, Hiltrud Brauch, Hermann Brenner, Louise A. Brinton, Angela Brooks‐Wilson, Fiona Bruinsma, Joan Brunet, Thomas Brüning, Agnieszka Budziłowska, Clareann H. Bunker, Barbara Burwinkel, Ralf Bützow, Saundra S. Buys, Maria A. Caligo, Ian Campbell, Jonathan Carter, Jenny Chang‐Claude, Stephen J. Chanock, Kathleen Claes, J. Margriet Collée, Linda S. Cook, Fergus J. Couch, Angela Cox, Daniel W. Cramer, Simon S. Cross, Julie M. Cunningham, Cezary Cybulski, Kamila Czene, Francesca Damiola, Agnieszka Dansonka‐Mieszkowska, Hatef Darabi, Miguel de la Hoya, Anna deFazio, Joseph Dennis, Peter Devilee, Ed Dicks, Orland Dı́ez, Jennifer A. Doherty, Susan M. Domchek, Cecilia M. Dorfling, Thilo Dörk, Isabel dos‐Santos‐Silva, Andreas du Bois, Martine Dumont, Alison M. Dunning, M. Durán, Douglas F. Easton, Diana Eccles, Robert P. Edwards, Hans Ehrencrona, Bent Ejlertsen, Arif B. Ekici, Steve D. Ellis, Christoph Engel, Mikael Eriksson, Peter A. Fasching, Lídia Feliubadaló, Jonine D. Figueroa, Dieter Flesch‐Janys, Olivia Fletcher, Annette Fontaine, Stefano Fortuzzi, Florentia Fostira, Brooke L. Fridley, Tara M. Friebel, Eitan Friedman, Grace Friel, Debra Frost, Judy E. Garber, Montserrat García‐Closas, Simon A. Gayther, Aleksandra Gentry‐Maharaj, Anne–Marie Gerdes, Graham G. Giles, Rosalind Glasspool, Gord Glendon, Andrew K. Godwin, Marc T. Goodman, Martin Gore, Mark H. Greene, Mervi Grip, Jacek Gronwald, Daphne Gschwantler Kaulich, Pascal Guénel, Starr R Guzman, Lothar Haeberle, Christopher A. Haiman, Per Hall, Sandra L. Halverson, Ute Hamann, Thomas van Overeem Hansen, Philipp Harter, Jaana M. Hartikainen, Sue Healey, Alexander Hein, Florian Heitz, Brian E. Henderson, Josef Herzog, Michelle A.T. Hildebrandt, Claus Høgdall, Estrid Høgdall, Frans B.L. Hogervorst, John L. Hopper, Keith Humphreys, Tomasz Huzarski, Evgeny N. Imyanitov, Claudine Isaacs, Anna Jakubowska, Ramūnas Janavičius, Katarzyna Jaworska, Allan Jensen, Uffe Birk Jensen, Nichola Johnson, Arja Jukkola‐Vuorinen, Maria Kabisch, Beth Y. Karlan, Vesa Kataja, Noah D. Kauff, Linda E. Kelemen, Michael J. Kerin, Lambertus A. Kiemeney, Susanne K. Kjær, Julia A. Knight, Jacoba P Knol-Bout, Irene Konstantopoulou, Veli‐Matti Kosma, Camilla Krakstad, Vessela N. Kristensen, Karoline Kuchenbaecker, Jolanta Kupryjańczyk, Yael Laitman, Diether Lambrechts, Sandrina Lambrechts, Melissa C. Larson, Adriana Lasa, Pierre Laurent‐Puig, Conxi Lázaro, Nhu D. Le, Loı̈c Le Marchand, Arto Leminen, Jenny Lester, Douglas A. Levine, Jingmei Li, Dong Liang, Annika Lindblom, Noralane M. Lindor, Jolanta Lissowska, Jirong Long, Karen H. Lu, Jan Lubiński, Lene Lundvall, Galina Lurie, L. Phuong, Graham J. Mann, Sara Margolin, Frédérique Mariette, Frederik Marmé, John W.M. Martens, Leon F.A.G. Massuger, Christine Maugard, Sylvie Mazoyer, Lesley McGuffog, Valerie McGuire, Catriona McLean, Iain A. McNeish, Alfons Meindl, F. Ménégaux, Primitiva Menéndez, Janusz Menkiszak, Usha Menon, Arjen R. Mensenkamp, Nicola Miller, Roger L. Milne, Francesmary Modugno, Marco Montagna, Kirsten B. Moysich, Heiko Müller, Anna Marie Mulligan, Taru Muranen, Steven A. Narod, Katherine L. Nathanson, Roberta B. Ness, Susan L. Neuhausen, Heli Nevanlinna, Patrick Neven, Finn Cilius Nielsen, Sune F. Nielsen, Børge G. Nordestgaard, Robert L. Nussbaum, Kunle Odunsi, Kenneth Offit, Edith Oláh, Olufunmilayo I. Olopade, Janet E. Olson, Sara H. Olson, Jan C. Oosterwijk, Irene Orlow, Nick Orr, Sandra Oršulić, Ana Osório, Laura Ottini, James Paul, Celeste Leigh Pearce, Inge Søkilde Pedersen, Bernard Peissel, Tanja Pejović, Liisa M. Pelttari, Jo Perkins, Jenny Permuth‐Wey, Paolo Peterlongo, Julian Peto, Catherine M. Phelan, Kelly‐Anne Phillips, Marion Piedmonte, Malcolm C. Pike, Radka Platte, Joanna Plisiecka-Hałasa, Elizabeth M. Poole, Bruce Poppe, Katri Pylkäs, Paolo Radice, Susan J. Ramus, Timothy R. Rebbeck, Malcolm Reed, Gad Rennert, Harvey A. Risch, Mark E. Robson, Gustavo C. Rodriguez, Atocha Romero, Mary Anne Rossing, Joseph H. Rothstein, Anja Rudolph, Ingo B. Runnebaum, Ritu Salani, Helga B. Salvesen, Elinor J. Sawyer, Joellen M. Schildkraut, Marjanka K. Schmidt, Rita K. Schmutzler, Andreas Schneeweiß, Minouk J. Schoemaker, Michael Schrauder, Fredrick R. Schumacher, Ira Schwaab, Giulietta Scuvera, Thomas A. Sellers, Gianluca Severi, Caroline Seynaeve, Mitul Shah, Martha J. Shrubsole, Nadeem Siddiqui, Weiva Sieh, Jacques Simard, Christian F. Singer, Olga M. Sinilnikova, Dominiek Smeets, Christof Sohn, Maria Soller, Honglin Song,

No clinical utility of KRAS variant rs61764370 for ovarian or breast

Elsevier BV

Felix R. Day, Katherine S. Ruth, Deborah J. Thompson, Kathryn L. Lunetta, Natalia Pervjakova, Daniel I. Chasman, Lisette Stolk, Hilary K. Finucane, Patrick Sulem, Brendan Bulik‐Sullivan, Tõnu Esko, Andrew D. Johnson, Cathy E. Elks, Nora Franceschini, Chunyan He, Elisabeth Altmaier, Jennifer A. Brody, Lude Franke, Jennifer E. Huffman, Margaux F. Keller, Patrick F. McArdle, Teresa Nutile, Eleonora Porcu, Antonietta Robino, Lynda M. Rose, Ursula M. Schick, Jennifer A. Smith, Alexander Teumer, Michela Traglia, Dragana Vuckovic, Jie Yao, Wei Zhao, Eva Albrecht, Najaf Amin, Tanguy Corre, Jouke‐Jan Hottenga, Massimo Mangino, Albert V. Smith, Toshiko Tanaka, Gonçalo R. Abecasis, Irene L. Andrulis, Hoda Anton‐Culver, Antonis C. Antoniou, Volker Arndt, Alice M. Arnold, Caterina Barbieri, Matthias W. Beckmann, Alicia Beeghly‐Fadiel, Javier Benı́tez, Leslie Bernstein, Suzette J. Bielinski, Carl Blomqvist, Eric Boerwinkle, Natalia Bogdanova, Stig E. Bojesen, Manjeet K. Bolla, Anne‐Lise Børresen‐Dale, Thibaud Boutin, Hiltrud Brauch, Hermann Brenner, Thomas Brüning, Barbara Burwinkel, Archie Campbell, Harry Campbell, Stephen J. Chanock, J. Ross Chapman, Yii‐Der Ida Chen, Georgia Chenevix‐Trench, Fergus J. Couch, Andrea D. Coviello, Angela Cox, Kamila Czene, Hatef Darabi, Immaculata De Vivo, Ellen W. Demerath, Joe Dennis, Peter Devilee, Thilo Dörk, Isabel dos‐Santos‐Silva, Alison M. Dunning, John D. Eicher, Peter A. Fasching, Jessica D. Faul, Jonine D. Figueroa, Dieter Flesch‐Janys, Ilaria Gandin, Melissa E. Garcia, Montserrat García‐Closas, Graham G. Giles, Giorgia Girotto, Mark S. Goldberg, Anna González‐Neira, Mark O. Goodarzi, Megan L. Grove, Daníel F. Guðbjartsson, Pascal Guénel, Xiuqing Guo, Christopher A. Haiman, Per Hall, Ute Hamann, Brian E. Henderson, Lynne J. Hocking, Albert Hofman, Georg Homuth, Maartje J. Hooning, John L. Hopper, Frank B. Hu, Jinyan Huang, Keith Humphreys, David J. Hunter, Anna Jakubowska, Samuel E. Jones, Maria Kabisch, David Karasik, Julia A. Knight, Ivana Kolčić, Charles Kooperberg, Veli‐Matti Kosma, Jennifer Kriebel, Vessela N. Kristensen, Diether Lambrechts, Claudia Langenberg, Jingmei Li, Xin Li, Sara Lindström, Yongmei Liu, Jian’an Luan, Jan Lubiński, Reedik Mägi, Graham J. Mann, Judith Manz, Sara Margolin, Jonathan Marten, Nicholas G. Martin, Corrado Masciullo, Alfons Meindl, Kyriaki Michailidou, Evelin Mihailov, Lili Milani, Roger L. Milne, Martina Müller‐Nurasyid, Michael A. Nalls, Benjamin M. Neale, Heli Nevanlinna, Patrick Neven, Anne B. Newman, Børge G. Nordestgaard, Janet E. Olson, Sandosh Padmanabhan, Paolo Peterlongo, Ulrike Peters, Astrid Petersmann, Julian Peto, Paul D.P. Pharoah, Nicola Pirastu, Ailith Pirie, Giorgio Pistis, Ozren Polašek, David J. Porteous, Bruce M. Psaty, Katri Pylkäs, Paolo Radice, Leslie J. Raffel, Fernando Rivadeneira, Igor Rudan, Anja Rudolph, Daniela Ruggiero, Cinzia Sala, Serena Sanna, Elinor J. Sawyer, David Schlessinger, Marjanka K. Schmidt, Frank Schmidt, Rita K. Schmutzler, Minouk J. Schoemaker, Robert A. Scott, Caroline Seynaeve, Jacques Simard, Rossella Sorice, Melissa C. Southey, Doris Stöckl, Konstantin Strauch, Anthony J. Swerdlow, Kent D. Taylor, Unnur Þorsteinsdóttir, Amanda E. Toland, Ian Tomlinson, Thérèse Truong, Laufey Tryggvadóttír, Stephen T. Turner, Diego Vozzi, Qin Wang, Melissa Wellons, Gonneke Willemsen, James F. Wilson, Robert Winqvist, Bruce H. R. Wolffenbuttel, Alan F. Wright, Drakoulis Yannoukakos, Tatijana Zemunik, Wei Zheng, Marek Zygmunt, Sven Bergmann, Dorret I. Boomsma, Julie E. Buring, Luigi Ferrucci, Grant W. Montgomery, Vilmundur Guðnason, Tim D. Spector, Cornelia M. van Duijn, Behrooz Z. Alizadeh, Marina Ciullo, Laura Crisponi, Douglas F. Easton, Paolo Gasparini, Christian Gieger, Tamara B. Harris, Caroline Hayward, Sharon L. R. Kardia, Peter Kraft, Barbara McKnight, Andres Metspalu, Alanna C. Morrison, Alex P. Reiner, Paul M. Ridker, Jerome I. Rotter, Daniela Toniolo, André G. Uitterlinden, Sheila Ulivi, Henry Völzke, Nicholas J. Wareham, David R. Weir, Laura M. Yerges-Armstrong, Alkes L. Price, Kári Stéfansson, Jenny A. Visser, Ken K. Ong, Jenny Chang‐Claude, Joanne M. Murabito, John R. B. Perry, Anna Murray,

Menopause timing has a major impact on infertility and risk of disease. Younger age at natural (nonsurgical) menopause (ANM) is associated with a higher risk of osteoporosis, cardiovascular disease, and type 2 diabetes and a lower risk of breast cancer. Late menopause is associated with a higher risk of breast cancer. It is well known that the age at which women go through menopause is partly determined by genes, but the underlying mechanisms are poorly understood. Genome-wide association studies ...

Tópico(s): Sex and Gender in Healthcare

2015 - Lippincott Williams & Wilkins | Obstetrical & Gynecological Survey

Gisella Figlioli, Massimo Bogliolo, Irene Catucci, Laura Caleca, Sandra Viz-Lasheras, Roser Pujol, Johanna I. Kiiski, Taru Muranen, Daniel R. Barnes, Joe Dennis, Kyriaki Michailidou, Manjeet K. Bolla, Goska Leslie, Cora M. Aalfs, Rosemary Balleine, Robert Baxter, Stephen Braye, Jane Carpenter, Jane E. Dahlstrom, John Forbes, C. Soon Lee, Deborah J. Marsh, Adrienne Morey, Nirmala Pathmanathan, Rodney Scott, Peter Simpson, Allan Spigelman, Nicholas Wilcken, Desmond Yip, Nikolajs Zeps, Muriel A. Adank, Julian Adlard, Simona Agata, Karen Cadoo, Bjarni A. Agnarsson, Thomas Ahearn, Kristiina Aittomäki, Christine B. Ambrosone, Lesley Andrews, Hoda Anton-Culver, Natalia Antonenkova, Volker Arndt, Norbert Arnold, Kristan J. Aronson, Banu K. Arun, Ella Asseryanis, Bernd Auber, Päivi Auvinen, Jacopo Azzollini, Judith Balmañà, Rósa B. Barkardóttir, Daniel Barrowdale, Julian Barwell, Laura E. Beane Freeman, Charles Joly Beauparlant, Matthias W. Beckmann, Sabine Behrens, Javier Benı́tez, Raanan Berger, Marina Bermisheva, Amie Blanco, Carl Blomqvist, Natalia Bogdanova, Anders Bojesen, Stig E. Bojesen, Bernardo Bonanni, Åke Borg, Angela F. Brady, Hiltrud Brauch, Hermann Brenner, Thomas Brüning, Barbara Burwinkel, Saundra S. Buys, Trinidad Caldés, Almuth Caliebe, Maria A. Caligo, Daniele Campa, Ian Campbell, Federico Canzian, Jose E. Castelao, Jenny Chang-Claude, Stephen J. Chanock, Kathleen Claes, Christine L. Clarke, Anita Collavoli, Thomas A. Conner, David G. Cox, Cezary Cybulski, Kamila Czene, Mary B. Daly, Miguel de la Hoya, Peter Devilee, Orland Diez, Yuan Chun Ding, Gillian S. Dite, Nina Ditsch, Susan M. Domchek, Cecilia M. Dorfling, Isabel dos‐Santos‐Silva, Katarzyna Durda, Miriam Dwek, Diana Eccles, Arif B. Ekici, A. Heather Eliassen, Carolina Ellberg, Mikael Eriksson, D. Gareth Evans, Peter A. Fasching, Jonine D. Figueroa, Henrik Flyger, William D. Foulkes, Tara M. Friebel, Eitan Friedman, Marike Gabrielson, Pragna Gaddam, Manuela Gago‐Dominguez, Chi Gao, Susan M. Gapstur, Judy Garber, Montserrat García‐Closas, José A. García-Sáenz, Mia M. Gaudet, Simon A. Gayther, Muriel Belotti, Ophélie Bertrand, Anne‐Marie Birot, Bruno Buecher, Sandrine M. Caputo, Anaïs Dupré, Emmanuelle Fourme, Marion Gauthier-Villars, Lisa Golmard, Marine Le Mentec, Virginie Moncoutier, Antoine de Pauw, Claire Saule, Nadia Boutry‐Kryza, Alain Calender, Sophie Giraud, Mélanie Léone, Brigitte Bressac–de Paillerets, Olivier Caron, Marine Guillaud-Bataille, Yves‐Jean Bignon, Nancy Uhrhammer, Stella Koutros, Christine Lasset, Pascaline Berthet, Laurent Castéra, Dominique Vaur, Violaine Bourdon, Catherine Noguès, Tetsuro Noguchi, Cornel Popovici, Audrey Remenieras, Hagay Sobol, Isabelle Coupier, Pascal Pujol, Claude Adenis, Aurélie Dumont, Françoise Révillion, Danièle Muller, Emmanuelle Barouk-Simonet, Françoise Bonnet, Virginie Bubien, Michel Longy, Nicolas Sevenet, Laurence Gladieff, Rosine Guimbaud, Viviane Feillel, Christine Toulas, Hélène Dreyfus, C LeRoux, Magalie Peysselon, Christine Rebischung, Clémentine Legrand, Amandine Baurand, Geoffrey Bertolone, Fanny Coron, Laurence Faivre, Caroline Jacquot, Sarab Lizard, Caroline Kientz, Marine Lebrun, Fabienne Prieur, Sandra Fert‐Ferrer, Véronique Mari, Laurence Vénat-Bouvet, Stéphane Bézieau, Capucine Delnatte, Isabelle Mortemousque, Chrystelle Colas, Florence Coulet, Florent Soubrier, Mathilde Warcoin, Myriam Bronner, Johanna Sokolowska, Marie‐Agnès Collonge‐Rame, Alexandre Damette, Paul Gesta, Hakima Lallaoui, Jean Chiésa, Denise Molina-Gomes, Olivier Ingster, Sylvie Manouvrier-Hanu, Sophie Lejeune, Graham G. Giles, Gord Glendon, Andrew K. Godwin, Mark S. Goldberg, David E. Goldgar, Pascal Guénel, Angelica M. Gutierrez‐Barrera, Lothar Haeberle, Christopher A. Haiman, Niclas Håkansson, Per Hall, Ute Hamann, Patricia Harrington, Alexander Hein, Jane Heyworth, Peter Hillemanns, Antoinette Hollestelle, John L. Hopper, Hung Chak Ho, Anthony Howell, Chunling Hu, Peter J. Hulick, David J. Hunter, Evgeny N. Imyanitov, Morteza Aghmesheh, Sian Greening, David J. Amor, Mike Gattas, Leon Botes, Michael Buckley, Michael Friedlander, Jessica Koehler, Bettina Meiser, Mona Saleh, Elizabeth Salisbury, Alison Trainer, Kathy Tucker, Yoland Antill, Alexander Dobrovic, Andrew Fellows, Stephen Fox, Marion Harris, Sophie Nightingale, Kelly Phillips, Joe Sambrook, Heather Thorne, Shane Armitage, Leanne Arnold, Rosemary Balleine, Richard Kefford, Judy Kirk, Edwina Rickard, Patti Bastick, Jonathan Beesley, Nicholas K. Hayward, Amanda Spurdle, Logan C. Walker, John Beilby, Christobel Saunders, Ian Bennett, Anneke Blackburn, Michael Bogwitz, Clara Gaff, Geoffrey J. Lindeman, Nick Pachter, Clare L. Scott, Adrienne Sexton, Jane Visvader, Jessica Taylor, Ingrid Winship, Meagan Brennan, Melissa A. Brown, Juliet D. French, Stacey L. Edwards, Matthew Burgess, Jo Burke, Briony Patterson, Phyllis Butow, Bronwyn Culling, Liz Caldon, David F. Callen, Deepa Chauhan, Maurice Eisenbruch, Louise Heiniger, Manisha Chauhan, Alice Christian, Joanne Dixon, Alexa Kidd, Paul A. Cohen, Alison Colley,