McBride, Jesse.Letter: River Styx, Medina County, Ohio, April 16, 1852, to George Whipple.
1852 - Gale Group | SAS Part 1
Shantá D. Hinton, Michael P. Myers, Vincent R. Roggero, Lizabeth A. Allison, Nicholas K. Tonks,
MK-STYX [MAPK (mitogen-activated protein kinase) phospho-serine/threonine/tyrosine-binding protein] is a pseudophosphatase member of the ... subfamily of the PTPs (protein tyrosine phosphatases). MK-STYX is catalytically inactive due to the absence of ... by serine and phenylalanine residues respectively in MK-STYX. Mutations to introduce histidine and cysteine residues into the active site of MK-STYX generated an active phosphatase. Using MS, we identified ... Ras signalling, as a binding partner of MK-STYX. We observed that G3BP1 bound to native MK- ...
Tópico(s): RNA Research and Splicing
2010 - Portland Press | Biochemical Journal
Alexander Street
McBride, Jesse.Letter: River Styx, Medina County, Ohio, May 4, 1852, to George Whipple.
1852 - Gale Group | SAS Part 1
Justinn E. Barr, Michelle Munyikwa, Elizabeth A. Frazier, Shantá D. Hinton,
The pseudophosphatase MK-STYX (mitogen-activated protein kinase phosphoserine/threonine/tyrosine-binding protein) has been implicated in the stress response pathway. The expression of MK-STYX inhibits the assembly of stress granules, which are ... heat shock, UV irradiation and hypoxia. Furthermore, MK-STYX interacts with a key component of stress granules: ... that the inhibition of stress granules by MK-STYX was G3BP-1 phosphorylation-dependent. However, in the present study, using MK-STYX constructs and G3BP-1 phosphomimetic or nonphosphorylatable mutants, ...
Tópico(s): ATP Synthase and ATPases Research
2012 - Wiley | FEBS Journal
Alexander Street
Photograph. Photograph of a Corded Poodle 'Styx' Sitting down. Gambier Bolton. Photographer: Gambier Bolton.
0000 - Gale Group | NCCO Photography
Brittany M. Flowers, Lauren Rusnak, Kristen E. Wong, Dallas A. Banks, Michelle Munyikwa, Alexander McFarland, Shantá D. Hinton,
... required. Here, we investigate the function of MK-STYX [MAPK (mitogen-activated protein kinase) phosphoserine/threonine/tyrosine-binding protein] in neuronal differentiation. MK-STYX is a member of the MAPK phosphatase (MKP) ... generally responsible for dephosphorylating the ERKs. However, MK-STYX lacks catalytic activity due to the absence of ... for phosphatase activity. Despite being catalytically inactive, MK-STYX has been shown to play a role in ... we show that PC12 cells endogenously express MK-STYX. In addition, MK-STYX, but not its catalytically ...
Tópico(s): Melanoma and MAPK Pathways
2014 - Public Library of Science | PLoS ONE
E. Ernest Goldstein, Francis Morris, Geoffrey Block, J.M. Reid,
... the Laager How Algiers Sees It Shell Korean Styx Togliatti's "Parliamentary Way" Greece Under the Peace ...
1960 - Gale Group | The Economist
Natalie M. Niemi, Juliana L. Sacoman, Laura M. Westrate, L. Alex Gaither, Nathan Lanning, Katie R. Martin, Jeffrey P. MacKeigan,
... the knockdown of the catalytically inactive phosphatase, MK-STYX [MAPK (mitogen-activated protein kinase) phospho-serine/threonine/ ... follow-up studies demonstrated that knockdown of MK-STYX prevents cells from undergoing apoptosis through a block in cytochrome c release, but that MK-STYX does not localize proximal to the molecular machinery ... approach to identify proteins that interact with MK-STYX. We identified the mitochondrial phosphatase, PTPMT1 (PTP localized ... most significant and unique interaction partner of MK-STYX. We previously reported that knockdown of PTPMT1, an ...
Tópico(s): Protein Tyrosine Phosphatases
2014 - Public Library of Science | PLoS ONE
J. H., AN OLD INHABITANT OF THE LOCALITY., SHREWSBURY., THOMAS CURME., J. D., AMOR GIGNIT AMOREM., AN ADMIRER OF CORRECT ARCHITECTURE., A BARRISTER., MATTHEW GODDARD., THE VICTIM OF FRAUD.,
... Cambridge, Dec. 2.-The, WOOLWICH, Dec. 2.-The Styx steam-vessel,, A ROMISH MIRACLE.-The Reparateur de ...
1842 - Gale Group | TDA
Dallas A. Banks, Arya Dahal, Alexander McFarland, Brittany M. Flowers, Christina A. Stephens, Benjamin Swack, Ayele Gugssa, Winston A. Anderson, Shantá D. Hinton,
We previously reported that the pseudophosphatase MK-STYX (mitogen activated kinase phosphoserine/threonine/tyrosine binding protein) dramatically increases the number of what appeared to be primary neurites in rat pheochromocytoma (PC- ... cells; however, the question remained whether these MK-STYX-induced outgrowths were bona fide neurites, and formed ... the formation of neurites, are present in MK-STYX-induced outgrowths. In addition, in response to nerve growth factor (NGF), MK-STYX-expressing cells produced more growth cones than non- ...
Tópico(s): Ubiquitin and proteasome pathways
2017 - Frontiers Media | Frontiers in Molecular Biosciences
Clive Small, Dan Jacobson, Captain Geoffrey Bennett RN, Phillip Whitehead, Jeremy Isaacs, John Naughton, Francis Rentoul, Neil Hepburn, Humphry Lynch, D. A. N. Jones, John Williams, Roy Hattersley, Ernest Pendrous, Nicholas Meckman, Zander, W. H. Hudson, Alan Ryan, Stephen Bayley, Paul Overy, Antony Part, Mark Haymon, David Sweetman, John Simpson, Charles Lock, Derwent May, Derek Winter, Gavin Millar, Anthony Howard, E. J. Monk, John Humphrys, Ray Gosling, John Elsom, George Gelber, P. J. Kavanagh, C. Witton-Davies, Meredith Oakes,
... Johnson Blackwell (Mainstream Series) £8.50 In the Styx The Story of Modern Art By Norbert Lynton ...
1980 - Gale Group | The Listener GDA
Yuming Cao, Dallas A. Banks, Andrew M. Mattei, Alexys Riddick, Kirstin Reed, Ashley Zhang, Emily S. Pickering, Shantá D. Hinton,
... inactive mitogen-activated protein (MAP) kinase phosphatase, MK-STYX (MAPK (mitogen-activated protein kinase) phosphoserine/threonine/tyrosine- ... component of stress granules. The discovery that MK-STYX and HDAC6 both interact with G3BP-1 led us to investigate the effects of MK-STYX on HDAC6 dynamics. In control HEK/293 cells, ... of stress. In contrast, in cells overexpressing MK-STYX, HDAC6 was both nuclear and cytosolic and the ... induced aggregates significantly decreased. Immunoblots showed that MK-STYX decreases HDAC6 serine phosphorylation, protein tyrosine phosphorylation, and ...
Tópico(s): Ubiquitin and proteasome pathways
2019 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
M. MUIR MACKENZIE., ARCH. GEIKIE., EDWARD A. WILSON., ANDREW T. TAYLOR, L.C.C., M.A., The Temple, May 15. H. G. WOODS., F. E. SMITH. May 15., GORDON INGLIS, Hon. Secretary, , ROBERT HUNTER, Chairman of,
... Flag Appointments.. Reviews: Coronet Theatre. "Cupid And The Styx." A Comedy in Three Acts., Auction Summary., Music. ...
1912 - Gale Group | TDA
Diao He, Zida Ma, Chao Fang, Jingjing Ding, Wenming Yang, Peng Chen, Libin Huang, Cun Wang, Yongyang Yu, Lie Yang, Yuan Li, Zong‐Guang Zhou,
Serine/threonine/tyrosine interacting protein (STYX), a member of protein tyrosine phosphatases, has recently been reported as a potential oncogene. However, the role of STYX in colorectal cancer (CRC) remains unknown. In this study, we found that STYX was highly expressed in CRC tissues and closely ... patients. In vitro studies showed that overexpression of STYX promoted proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) and inhibited apoptosis in CRC cells, while STYX knockdown had the opposite effects. Consistently, in vivo ...
Tópico(s): Liver physiology and pathology
2019 - Elsevier BV | Cancer Letters
... Are Awful Slow, Old Charon on the River Styx, Is Likewise in the Selfsame Fix!, Diamond Fields ...
1908 - Gale Group | NCCO EuropeAfrica
Natalie M. Niemi, Nathan Lanning, Jeffrey A. Klomp, Stephen W. G. Tait, Yong Xu, Karl Dykema, Leon O. Murphy, L. Alex Gaither, H. Eric Xu, Kyle A. Furge, Douglas R. Green, Jeffrey P. MacKeigan,
... phosphatases in the human genome.We identified MK-STYX (STYXL1), a catalytically inactive phosphatase with homology to ... protein kinase (MAPK) phosphatases.Despite this homology, MK-STYX knockdown does not significantly regulate MAPK signaling in ... apoptotic stimuli.Rather, RNAi-mediated knockdown of MK-STYX inhibits cells from undergoing apoptosis induced by cellular stressors activating mitochondrion-dependent apoptosis.This MK-STYX phenotype mimics the loss of Bax and Bak, ... of both Bax and Bak, cells without MK-STYX expression are unable to release cytochrome c.Proapoptotic ...
Tópico(s): Ubiquitin and proteasome pathways
2011 - Taylor & Francis | Molecular and Cellular Biology
Andrew Robson, Robert Cole, Christopher, Andrew Pierce, DJM, Chris Ward, Fred Redwood, Zahid Hussain, Adam Sherwin Media Reporter, Magnus Linklater, Helga Harrison, David Russell, Peter Lansley, Rosalind Plowright, James Peterson, Mark Souster, Shares, David Rhys Jones, Dominic Kennedy Crime Writer, Philip Howard, Ian Cobain, Hilary Finch, Christine Seib, Nic Hopkins, Ben Webster and Greg Hurst, Clive Davis, Alexandra Frean Social Affairs Correspondent, Chris Bowers, Gabrielle Starkey, Rosalind Renshaw, Carl Mortished, Gillian Harris Scotland Correspondent, Sam Marlowe, Joe Joseph, Andrew Norfolk, Alastair Campbell, David Sharrock, Pat Gibson, David McVay, Donald Hutera, Alan Lee the Course Inspector, Victoria Rosenberg, Stewart Tendler Crime Correspondent, Jennai Cox Fitness Editor, Anthony Browne, Tom Bawden, Erica Wagner Literary Editor, Gerald HARTUP(Director), Jill Dupleix, T. W. Wright (Staffordsire Yeomanry), Ruth Gledhill Religion Correspondent, Dalya Alberge Arts Correspondent, Dan Sabbagh, Martin-Jenkins Chief Cricket Correspondent, Phoebe Greenwood, Richard Ford Home Correspondent, Rodney Legg, Alan Hamilton, James Delingpole, Roland Watson, Richard Lloyd Parry, Charles Bremner, Matt Dickinson Chief Football Correspondent, Bronwen Maddox Foreign Editor's Briefing, David Charter, Steve McGuire(Senior Lecturer in International Business), Dan Sabbagh and Abigali Rayner, Charles Ross, Philip R. Matthews (Chairman), Paul Spicker, Oliver Kay, Jane Gordon, Lisa Armstrong, Tom Baldwin, Mark Henderson Science Correspondent, Brian North Lee, Ann Treneman, Rob Wright, Geoffrey Dean, Elaine Monaghan, Susan Pape, Neil Harman Tennis Correspondent, Martin Samuel, Raymond Keene, Adam Sage, John Russell Taylor, Peter Riddell Political Briefing, Steve Boggan, Natalle Bennett, Charles Allan, Philip Mann, Philip Webster and David Charter, Rosemary Bennett Deputy Political Editor, Xan Rice, Nigel Hawkes, Jim Spillius, Peta Bee, Chris Campling, Cathy Harris, Nick Hasell, Dalya Alberge, Joanna Pitman, John Goodbody, Mary Ann Sieghart, Tosin Sulaiman, Mel Webb, Steven Pollard, Catherine Philp South Asia Correspondent, Angus Clarke, Anjana Ahuja, Eric Ellis, Ben Webster, Richard Beeston Diplomatic Editor, David Charter Chief Political Correspondent, John Szemerey, Simon Jenkins, Anne Ashworth Personal Finance Editor, Gary Duncan Economics Correspondent, Martin Waller, Nigel Hawkes Health Editor, Sarah Butler, Benedict Nightingale, Stephen Dalton, Dominic Kennedy and Stewart Tendler, Frances Gibb, Randy Cohen, Alan Lee Racing Correspondent, Catherine Quinn, Emma Burns, Jenny Davey, Richard Ford, Patience Wheatcroft, Christopher Irvine,
... up fees provide income stream Myth of the Styx Family-tree huggers Past Letters to the Editor ...
2004 - Gale Group | TDA
... of 33 adult and 10 juvenile specimens. Cateria styx from Brazil is redescribed from 33 adult and ... gerlachi from India and new material of C. styx from Chile have been studied for comparison. Cateria gerlachi can be distinguished from C. styx by leaf-like cuticular hairs dorsally but not ... midsternal plate of segments 1–2 in C. styx, fewer lines of leaf-like hairs of the ... lateral accessory vs a lateroventral position in C. styx, the lack of a midlateral spine on segment ... vs its existence on segment 11 of C. styx, the lack of a protrusible dorsal organ at ...
Tópico(s): Plant Diversity and Evolution
2015 - Q15088586 | Zootaxa
Nadia Comaneci, John Huxley, William Kay, Patricia Jones, Roger Eglin Industrial Editor, Will Ellsworth-Jones, Jon Swain, Philip Norman, Alan Gibson, Rob Hughes, Peter Marson, Dorian Wood Teacher, Chris Tighe, Marion Dailey, Peter Wilby Sunday Times education correspondent, J N Duncanson, Berry Ritchie, Graham Rose, David Beake, Andrew Saint, Julian Symons, Jason Tomas, Geoffiey Cannon, Jancis Robinson, Jocasta Innes, Pat Rice Retired Headmaster, Henry Brandon, Richard Milner, Deryk Brown, Mick Brown, Keith Botsford, David Dougill, Joe Irving, Dr D J Watmough, Veronica Horwell, Dudley Doust -, Derek Jewell, Johnny Black, Edmund Stevens, Nick Mason, Norman Harris, David Blundy, Geoff Whitten, Michael Meacher MP, Lionel Barber, Robert Troop, Robin Marlar, Tony Willard, Lesley Garner, Patric Dickinson, Juliet Alexander, Patrick Forman, Walter Merricks, Roger Eglin, Chris Cooper, James Tucker, Michael Rosen, Angela Newing, Michael Glenny, Nicholas Penny, Ronald Buchanan, Marjorie Wallace, George Rosie, Brian Jackman, Judith Jackson, Dr. John M. Kelly, Nick Gilbert, Celia Haddon, Eric Marsden, David Robson, Hugo Young Political Editor, Helen Stinson, Bryan Silcock, Stephen Pile, Gareth Huw Davies, Malcolm Winton, James Wilson, David May, Desmond Shawe-Taylor, Betka Zamoyska, Alan Brien, Russell Davies, Gwen Nuttall, Mike Phillips, Barry Pickthall, John Anderson Secretary, Philip Finnegan, Patrick Rowley, Dr Stephen Shaw Director, Prison Reform Trust, Dilys Powell, David Lipsey, Brough Scott, Bill Cater, Deyan Sudjic, Dr Anna Ridehalgh, Clive Everton, Tony Osman, Stuart Alexander, Robert Blicq-Lecoutre, Neil Lyndon, Felix Aprahamian, Stephen Fay, Rick Sanders, Peter Shearlock City Editor, Peter Clarke, Godfrey Smith, Mitchell Reiss, Andrew Stephen, Suzanne Lowry, Brian Glanville, Keith Richardson, Graham Searjeant, James Fenton, Michael Green, Rev Alexander Kirby, Trevor Brooking, Michael Jones Political Correspondent, Roy Perrott, Jon Connell Defence Correspondent, Marina Vaizey, James Danziger, Ian Robertson, Amir Taheri, Phillip Knightley, Malcolm Crawford, Peter Wilby Education Correspondent, E. Bentley Beauman, Nicholas Kenyon, Patience Wheatcroft, Joan Smith, Isabel Hilton, Boris Schapiro,
... Multiple Classified Advertising Items Multiple Display Advertising Items Styx Theatre Royal Drury Lane Multiple Display Advertising Items ...
1981 - Gale Group | Sunday Times HA GDA
Matthew J. Wishart, John M. Denu, John A. Williams, Jack E. Dixon,
... identified a novel phosphoserine/threonine/tyrosine-binding protein (STYX) that is related in amino acid sequence to ... A+) RNA revealed an alternatively spliced form of STYX containing a unique carboxyl terminus. Bacterially expressed STYX is incapable of hydrolyzing Tyr(P)-containing substrates; ... of dsPTPases, confers phosphatase activity to this molecule. STYX-G120C mutant hydrolyzes p-nitrophenyl phosphate and dephosphorylates ... identified a novel phosphoserine/threonine/tyrosine-binding protein (STYX) that is related in amino acid sequence to ...
Tópico(s): PI3K/AKT/mTOR signaling in cancer
1995 - Elsevier BV | Journal of Biological Chemistry
Peter Forbes, Brain Winston, John Pilger, John Dugdale, Robert Irwin, Nigel Andrew, Margaret Walters, Michael White, Derek Cooper, Hortense Wackett, James Saynor, Richard Combs, Bernard Keeffe, Alan Myers, Malcom Hayes, Paul Binding, Kathy Acker, Roger Woddis, Malcolm Hayes, Michael Pye, Jim Hiley, David Self, Roger Bolton Contorller, M. L. Cox, Martin Short, Peter Fiddick, John Fordham, Brian Wenham, Peter Tinniswood, John Cole, Sabre, Ronald Sturt, Sally Hardcastle, David Leigh, Lynne Truss, John Clute, John Lahr, Polly Toynbee, Stephanie Jordan, Benjamin Woolley, Harry Weisbloom, Richard Cork, David M. Duckels, Christopher Potter,
... We Are for the Dark On the River Styx Peter Matthiessen Collins Harville £10.95 Oxford University ...
1989 - Gale Group | The Listener GDA
Veronika Reiterer, Krzysztof Pawłowski, Hesso Farhan,
The pseudophosphatase STYX (serine/threonine/tyrosine interacting protein) is a catalytically inactive member of the protein tyrosine phosphatase family. We perform a phylogenetic analysis of STYX and ask how far does the pseudoenzyme status of STYX reaches in evolution. Based on our previous work, we use STYX as a showcase to discuss four basic modes ... exert. Our previous work on the effect of STYX on mitogen-activated protein kinase (MAPK) signaling led ... complementary modes of action. On the one hand, STYX competes with active phosphatases for binding to MAPKs. ...
Tópico(s): Protein Kinase Regulation and GTPase Signaling
2017 - Portland Press | Biochemical Society Transactions
Ladbroke Black, Angel H. Hart, Algernon Ashton, James A. Manson, L. R., Carlotta C. Lyon, J. W. Tiokel, Mr. Justice Bucnnill, Charles T. H. Hinton, E. C., Donald Norman Reid, F. G. Bettany, Hill Rowan, Sydney H. Pardon, Helena M. Norris, John T. Catterall, Vera Webster, W. E. Woodgate, La Villes, Magpie, Henry L. Clark, J. P. Bacon Phillips, Barbara, L. Van Vliet, J. T. Grein, Bernard Darwin, M. Hedge, R. C. H. Bemister, F. J. C., W. R.,
... Nearly £20,000 Profit Empire Revue "Over the Styx" Election Intelligence North Cumberland Tango and Turkey Trot ...
1913 - Gale Group | Sunday Times HA GDA
Veronika Reiterer, Cristina Figueras-Puig, François Le Guerroué, Stefano Confalonieri, Manuela Vecchi, Dasaradha Jalapothu, Sandip M. Kanse, Raymond J. Deshaies, Pier Paolo Di Fiore, Christian Behrends, Hesso Farhan,
... have mapped the interactome of the enigmatic pseudophosphatase STYX We reasoned that a catalytically inactive phosphatase might have adopted novel mechanisms of action. The STYX interactome contained several F-box proteins, including FBXW7. We show that STYX binds to the F-box domain of FBXW7 ... disables its recruitment into the SCF complex. Therefore, STYX acts as a direct inhibitor of FBXW7, affecting ... its substrates. Furthermore, we find that levels of STYX and FBXW7 are anti-correlated in breast cancer ...
Tópico(s): Endoplasmic Reticulum Stress and Disease
2016 - Springer Nature | The EMBO Journal
Ohio Farmer, Jeff'N Davis, "Talahala", Jeptha Fowlkes, W. L. Yancey, Philadelphia Argus,
... British Outrages The Outrage by the British Steamer Styx, By Telegraph! Expressly for the Mississippian. Editorial: The ...
1858 - Gale Group | SASII
... of four separate rivers: Acheron, Pyriphlegethon, Cocytus, and Styx: (10.513–15) There into Acheron flow Pyriphlegethon ... which is a branch of the water of Styx, and there is a rock, and the junction ... only named river in the Underworld is the Styx (2.755,3 8.369, 14.271, 15. ... to the other three. Likewise in the Odyssey Styx is referred to elsewhere (as the river that ... so do Pyriphlegethon and Kokytos as well as Styx, and also Acheron."5 In response to the ... the fact that Hesiod seems to know only Styx (Theog. 383, 389–403, 775–806), questions inevitably ...
Tópico(s): Maritime and Coastal Archaeology
1999 - Johns Hopkins University Press | The American Journal of Philology