FROM OUR HORTICULTURAL CORRESPONDENT, From a Golf Correspondent, FROM A LAWN TENNIS CORRESPONDENT, FROM OUR ASSOCIATION FOOTBALL CORRESPONDENT, FROM A CRICKET CORRESPONDENT, FROM OUR RUGBY FOOTBALL CORRESPONDENT, FROM OUR RACING CORRESPONDENT, FROM OUR NORTHERN RACING CORRESPONDENT, From Our Special Correspondent, FROM OUR CORRESPONDENT, FROM OUR LABOUR CORRESPONDENT, FROM OUR SCIENCE CORRESPONDENT, FROM OUR ESTATES CORRESPONDENT, FROM OUR SCOTTISH CORRESPONDENT, FROM OUR SPECIAL CORRESPONDENT, From Our Correspondent, FROM OUR OWN CORRESPONDENT, BY MONITOR, From Our Own Correspondent, From Our Middle East Correspondent, From Our United Nations Correspondent, FROM OUR POLITICAL CORRESPONDENT, FROM OUR DIPLOMATIC CORRESPONDENT, L. A. TEMPLEMAN SPEER., L. SCOTT, ALAN HEDGES., BRIAN HARRISON., PATRICIA HASTINGS, DE LA WARR., FRANCIS N.BEAUFORT-PALMER, DAVID HOWARTH, KATHLEEN FIELD-HYDE., FROM A CORRESPONDENT, H. S. A., Dame Barbara Brooke, A brother, Brigadier R. E. Pickering, A friend, A correspondent, FROM A COLLECTOR, By Our City Editor, FROM OUR SHIPPING CORRESPONDENT,
... Of Life, Sikh Temple Raided Arrest Of Punjabi Suba Agitators, Diary Of Next Week's Events, Hospitals ...
1961 - Gale Group | TDA
Julian Lindsay, Indy Sandaradura, Kelly Wong, Chris Arthur, William Stevenson, Ian Kerridge, Keith Fay, Luke Coyle, Matthew Greenwood,
... levels, safety and tolerability of a novel formulation SUBA-itraconazole (where SUBA stands for SUper BioAvailability) when compared with conventional ... of 57 patients were assessed: 27 in the SUBA-itraconazole cohort and 30 in the liquid itraconazole ... concentrations were achieved significantly more quickly in the SUBA-itraconazole group: median of 6 (95% CI 5– ... in 69% (95% CI 44%–81%) of the SUBA-itraconazole group versus 21% (95% CI 7%–33%) ... mean trough serum concentrations at steady-state of SUBA-itraconazole were significantly higher, with less interpatient variability [ ...
Tópico(s): Fungal Infections and Studies
2017 - Oxford University Press | Journal of Antimicrobial Chemotherapy
T. C. Bishop, R. J. Pearce, J. B. Jevons, C. Wardle, W. J. Wild,
... Presentation of a Silver Medal Chain to Bey Suba of Mabileh, French Operations in Dahomey, Local, Holy ...
1892 - Gale Group | NCCO EuropeAfrica
Andrej Spec, George R. Thompson, Marisa H. Miceli, Justin F Hayes, Laurie A. Proia, David S. McKinsey, Ana Belén Araúz, Kathleen M. Mullane, J. TIMOTHY YOUNG, Gerald McGwin, Rachel McMullen, Tyler Plumley, Mary K. Moore, Lee Ann McDowell, Carolynn Thomas Jones, Peter G. Pappas,
... with significant morbidity and mortality. Super-bioavailability itraconazole (SUBA-itra) is a novel antifungal agent with pharmacokinetic ... randomized trial evaluated the efficacy, safety, and pharmacokinetics SUBA-itra compared with conventional itraconazole (c-itra) treatment ... Results Eighty-eight patients were enrolled for IFD (SUBA-itra, n = 42; c-itra, n = 46) caused ... On day 42, clinical success was observed with SUBA-itra and c-itra on day 42 (in ... 180 (in 60% and 65%). Patients treated with SUBA-itra exhibited less drug-level variability at days ...
Tópico(s): Infectious Diseases and Mycology
2024 - Oxford University Press | Open Forum Infectious Diseases
Gerry Fitt, Egon Klepsch (President), Susan K. Gerrard-Wright, Malcolm Brown, Alan R. Del Mar, Peter Dear and Stephanie Billen, Graham Rock, John Page, Director, Patricia Davies, Stephen Leather, Andrew Longmore, Neil Bennett, Mark Souster, Cliff Feltham, Sheridan Morley, Ivo Tennant, Robin Oakley, Philip Howard, Ian Murray, James Bone, George Sivell, Mandarin (Michael Phillips), Richard Evans, Media Editor, Carol Leonard, R. E. J. Gerrard-Wright, Richard Streeton, Richard Eaton, Kevin Eason, Colin Narbrough, Joe Joseph, Brian James, Martin Fletcher, Gerald Isaaman, Editor, Henry Gee, Bryan Stiles, Jim Railton, Stuart Jones, Robin Pellew (Director), Michael Tate, John Lewis, Political Staff, Ruth Gledhill, Jill Sherman, Social Services Correspondent, Louise Taylor, Roland Rudd Employment Affairs Reporter, Peter Waymark, Michael Evans, Defence Correspondent, Chris Smart, Ray Kennedy, Alan Hamilton, Jenny MacArthur, Michael Clark, Martin Fletcher, Political Reporter, John Young, Kevin Eason Motoring Correspondent, Charles Bremner, John Percival, John Hennessy, Martin Fletcher Political Reporter, Winifired Ewing, Jane Wyatt, Sally Watts, John Woodcock, Danielle Robinson, Raymond Blackburn, David Miller, Mitchell Platts Golf Correspondent, Philip Webster, Chief Political Correspondent, Geoffrey Wheeler, Alan Toogood, Horticulture Correspondent, Philip Webster and Rodney Lord, E. R. Moorhouse, Robin Oakley, Political Editor, Catherine Sampson, Kerry Gill, William Holmes, Peter Davalle, David Brewerton Executive Editor, Alan Lee, Cricket Correspondent, Nicholas Beeston, Leonard Krikler, Barbara Amiel, Raymond Keene, Chess Correspondent, James Sherr, Paul Griffiths, Andrew McEwen, Diplomatic Correspondent, Peter Bryan, Richard Evans, Heather Kirby, Jamie Dettmer Irish Affairs Correspondent, Mark Herbert, Jill Sherman, Richard Owen, Richard Evans Media Editor, David Young, Energy Correspondent, Richard Ford, Legal Affairs Reporter, Barry Pickthall, Irving Wardle, Joyce Whitehead, Ian Ross, David Sapsted, Brian Beel, Michael Hornsby, Agriculture Correspondent, Jean MacNicol, Rodney Hobson, Mr Gustav Holst Composer and Teacher, Henri Saby (Vice-President), John Goodbody, Philip Webster Chief Political Correspondent, Mandarin, Sam Kiley, Higher Education Reporter, Robert Matthews, Technology Correspondent, Matthew Parris, Clive White, Michael Austin, Michael Evans, Andrew McEwen and Philip Webster, B. A. Castle, Simone Veil (President), David Sinclair, Stephen Pettitt, Edward Hornby, Martin Waller, George Chesterton, Alan Coren, M. Hiskett, Ian P. Bell, Bailey Morris, Rodney Lord, Economics Editor, David Powell, Jack Bailey, Derek Harris Industrial Editor, Susan MacDonald, Maria Scott, David Sapsted and Richard Ford, Christoper Prout (President), Colin Campbell, Tim Jones, Employment Affairs Correspondent, Philip Jacobson, Pat Kidd, Jane Armstrong and Doreen Massey, John M. Howell, Mary Dejevsky, Stuart Jones, Football Correspondent,
... drop MEP on flight charge Murder charge GP Suba keeps chess lead The Traditional Garden Free Supplement ...
1989 - Gale Group | TDA
Lichao Zhang, Zongwei Li, Tonglin Shi, Xiaoqin La, Hanqing Li, Zhuoyu Li,
... is a virulent cytotoxin, and the subunit A (SubA) of it is able to destroy the structure ... constructed and expressed a fusion protein of GBP-SubA in E. coli Rosetta (DE3) system, in which ... were performed. Our data indicated the purified GBP-SubA could bind GRP78 existed on cancer cell surface ... apoptosis. Moreover, the apoptosis induction effect of GBP-SubA was enhanced obviously along with the increased cancer ... surface GBP78.It indicates that the recombinant GBP-SubA possesses the dual functions of GBP and SubA ...
Tópico(s): Signaling Pathways in Disease
2016 - BioMed Central | BMC Biotechnology
M. A. Jones, Chief Executive, Selkirk, R. B. Richardson, A.g.dunn, Mike Graham, Andrew McEwen, Mike Lamb, Frank C. Evans, Simon Barnes, Jasper Rees, Stephen Leather, Andrew Longmore, Neil Bennett, Ivo Tennant, Douglas Broom, Education Reporter, Philip Howard, Ian Murray, Michael Binyon, Carol Leonard, Richard Streeton, Richard Eaton, Jenny Knight, Roddy Forsyth, Norman Hammond, Archacology Correspondent, Michael Seely Racing Correspondent, Joe Joseph, David Tweed, John R. Sparkes, Henry Gee, Allan Massie, Pamela Thayer, Mark Souster and David Nicholson-Lord, D. Gwilym M Roberts, Roland Rudd, Employment Affairs Reporter, Jill Sherman, Social Services Correspondent, Raymond Keene Chess Correspondent, Dublin, Scrivener, Louise Taylor, K. Sharpe, Peter Waymark, Michael Evans, Defence Correspondent, Michael McCarthy, Environment Correspondent, Philip Robinson, John Young, Patricia Tisdall, Kevin Eason Motoring Correspondent, Charles Bremner, Michael Evans, Michael Binyon and Frederick Bonnart, Rex Bellamy, Tennis Correspondent, Ken Rawnsley, Paul Vallely, Ronald Faux and Harry Debelius, Steven Downes, W. T. Hutton, John Woodcock, Winston S. Churchill, Sydney Friskin, Colin F. McCARRAHER, Wolfgang Munchau and Neil Bennett, Dennis Signy, Robin Oakley Political Editor, Terence Willey, Geoffrey Wheeler, Mitchell Platts Golf Correspondent, Catherine Sampson, Kerry Gill, H. W. R. Wade, Peter Davalle, John Russell Taylor, Raymond Keene, Chess Correspondent, W. M. Forrest, Sean Overend, Paul Griffiths, Michael J Hendrie, Peter Bryan, Roland Rudd, Conrad Voss Bark, Sheila Gunn, Political Staff, J. M. Taylor, John Blunsden, Richard Owen, John Bell, Martin Searby, Richard Ford, Legal Affairs Reporter, Maxwell Newton, Alan Budd, Derek Harris, Industrial Editor, John Goodbody, David Young, George Hill, Clive White, F. G. St Clair Strange, Malcolm McKeag, Robert J. Fenwick Elliott, Paul Newman, Liz Smith, Jack Straw, Sarah Jane Checkland Art Market Correspondent, Keith Blackmore, Michael Austin, Emlyn Jones, Alan Lee Cricket Correspondent, David Sinclair, Roddy Mackenzie, G. W. T. Barnett, Paul Cavadino, Alan Coren, Christopher Warman, Bailey Morris, Jack Bailey, Rosalind Heywood, Susan MacDonald, Andrew McEwen Diplomatic Correspondent, Colin Campbell, Judy Froshaug, Tim Jones, Employment Affairs Correspondent, C. David Naish, David Young Energy Correspondent, Frank Selby, Michael Coleman, Michael Llanos, Rodney Lord Economics Editor, James j.McGovern, Mary Dejevsky, Richard Battley, John Watson, Michael Hornsby Agriculture Correspondent,
... eye for surreal medical art Two wins push Suba ahead of chess field Reuter: West Germans quarrel ...
1989 - Gale Group | TDA
Antony Prabhu, Bhaswati Sarcar, Soumen Kahali, Shan Yuan, Prakash Chinnaiyan,
... tumor activity of the novel fusion protein EGF-SubA, which combines EGF with the cytotoxin SubA that has been recently shown to selectively cleave GRP78. EGF-SubA demonstrated potent tumor-specific proteolytic activity and cytotoxicity ... To determine if the tumor microenvironment influences EGF-SubA activity, we maintained cells in acidic conditions that led to both UPR activation and increased EGF-SubA induced cytotoxicity. EGF-SubA was well tolerated in mice and led to ... through specific, proteolytic cleavage with the immunotoxin EGF-SubA represents a novel and promising multi-targeted approach ...
Tópico(s): Protein Structure and Dynamics
2012 - Public Library of Science | PLoS ONE
... By Telegram, Deaths, General News Death of Pa Suba—Mabileh. Business: The Trade of Sierra Leone in ...
1893 - Gale Group | NCCO EuropeAfrica
Joanne Abbotsford, David A. Foley, Zoy Goff, Asha C Bowen, Christopher C. Blyth, Daniel K. Yeoh,
... oral formulations. A formulation of ‘SUper BioAvailability itraconazole’ (SUBA-itraconazole; Lozanoc®) has been developed, with adult studies ... and attainment of therapeutic drug levels of the SUBA-itraconazole formulation in children. Methods A single-centre ... cohort study was conducted, including all patients prescribed SUBA-itraconazole from May 2018 to February 2020. The ... kg/day for prophylaxis. Results Nineteen patients received SUBA-itraconazole and the median age was 12 years. ... 81%) demonstrated a therapeutic response in IgE level. SUBA-itraconazole was well tolerated with no cessations related ...
Tópico(s): Respiratory and Cough-Related Research
2020 - Oxford University Press | Journal of Antimicrobial Chemotherapy
... Presentation of a Silver Medal Chain to Bey Suba of Mabileh, You Must Have a Good Stove, ...
1892 - Gale Group | NCCO EuropeAfrica
Hiroshi Yamamoto, Nozomi Sato, Toshiharu Shikanai,
... a supercomplex with photosystem I (PSI). Subcomplex A (SubA) mediates the electron transport and consists of eight ... both plastid and nuclear genomes. The assembly of SubA in the stroma has been extensively studied, but it is unclear how SubA is incorporated into the membrane-embedded part of ... embedded subunit localized to the connecting site between SubA and the membrane subcomplex (SubM). To analyze the ... plants indicated that NdhA was essential for stabilizing SubA and SubE but not for the accumulation of ...
Tópico(s): ATP Synthase and ATPases Research
2020 - Oxford University Press | Plant and Cell Physiology
Karan Thapar, D. P. Mason, Hm Inspector of Anatomy, Executive Editor David Brewerton, Pauline Skypala, Paul Vallely and Stewart Tendler, Chris Petit, Graham Rock, S. Ahmedzai (Medical Director and honorary consultant physician), Andrew Billen, Clifford Longley, Anatol Lieven, Daniel Ward, Motor Industry Correspondent, Jane MacQuitty, Victor Zorza and Veenu Sandal, Simon Barnes, Peter Philp, Stephen Leather, Marek Garztecki, Ronald Faux, J. H. Deam, Philip Goodhart, Angus Nicol, Allan Hoite, Sheridan Morley, Ivo Tennant, Douglas Broom, Education Reporter, Linda Pentz, Michael Seely, Racing Correspondent, F. P. Thornton, Hilary Finch, Dennis Corner, Conrad H. Gempf, Jeremy Kingston, Mark Whittet, Noel Goodwin, Geoffrey Mulcahy, Phil Sayer, Jeremy Flint, Patrick Masters, Richard Eaton, Mario Modiano, Rasit Gurdilek and Hazhir Teimourian, Colin Narbrough, John Spicer, Employment Affairs Correspondent, Bernard Levin, Francesca Greenoak, John Watson, Ahmed Fazl, Mohsin Ali, Norman Hammond, Archaeology Correspondent, Andrew Moger, David Giddings, Desmond Morris and Peter Marsh, Lawrence Lever, Roland Rudd Employment Affairs Reporter, Peter Ellwood, Peter Ackroyd, Peter Waymark, Peter de Savary, Martin Cropper, David Smith Economics Correspondent, Thomson Prentice, Science Correspondent, Roger Lean Vercoe, David Barnes, Richard Lockwood, Frances Bissell, Tony Winlaw, Maureen Gray, David Hands, Owen Hickey, Richard Thomson, Banking Correspondent, Rex Bellamy, Tennis Correspondent, J. M., Vaughan Purvis, Ros Drinkwater, Jane Rackham, Alex McWhirter, Simon Martin-Redman, Gavin Bell, John Woodcock, David Cross, John Holmes, Sydney Friskin, Shona Crawford Poole Travel Editor, David Smith, Economics Correspondent, Nigel Andrew, Geoffrey Wheeler, Wolfgang Münchau, John Higgins, Christopher Goulding, Kerry Gill, Raymond Keene, David Robinson, F. G., Raymond Keene, Chess Correspondent, Roy Hay, Yvonne E. Collins, Steve Acteson, Peter Bryan, Alexandra Jackson, J. S. Lester, Secretary, Robin Neillands, Martin Trew, David Young, Energy Correspondent, Barry Pickthall, Peter Brimelow, Geoffrey Foster, Bryan Appleyard, Richard Bassett, Sheila Gunn Political Staff, Derek Harris, Industrial Editor, Keith MacKlin, Deyan Sudjic, Kenneth Fleet, Peter Mulligan and Andrew Morgan, Christopher Thomas, Ian Smith, Rugby, Christopher Walker, Carol Ferguson, Srikumar Sen Boxing Correspondent, Graham Searjeant, Financial Editor, Clive White, Paul Gallico, Alan Franks, Michael Seely, Alan Lee, Tony Dawe, Alan Lee Cricket Correspondent, Michael Phillips, Ruth Sharman, David Sinclair, Joseph Palca, Susan MacDonald and David Cross, Mel Webb Crans-sur-Sierre, Jonathan Meades, Richard Morrison, Jack Bailey, Derek Harris Industrial Editor, Maria Scott, Richard Ford, Political Correspondent, Pearce Wright, Science Editor, Tony Hetherington, Judy Froshaug, John Smith, Chairman, Philip Jacobson, David Hands, Rugby Correspondent, Richard Ford, Anthony Cox, Anthony Swainson, Alan Ross, Philip Ray, Richard Williams, Hazel Spink,
... assertive cuisine Victims of a double squeeze Bridge Suba's stylish attack Chess Winning Move If there' ...
1988 - Gale Group | TDA
Huan Yu, Lei He, Zi‐Qi Li, Ni Li, Yi‐Yi Ou‐Yang, Guo‐Hua Huang,
... 3h, the functions of CaN subunit A (SeCaN‐SubA) and CaN binding protein (SeCaN‐BP) were analysed. ... vitro assays indicated that the bacterial expressed SeCaN‐SubA is an acid phosphatase, but no phosphatase activity ... purified SeCaN‐BP. The transcription level of SeCaN‐SubA was upregulated after HvAV‐3h infection and the ... HvAV‐3h causes the upregulated expression of SeCaN‐SubA and the appearance of SeCaN‐BP. An interaction between the cleaved SeCaN‐SubA and SeCaN‐BP was detected by co‐immunoprecipitation ...
Tópico(s): Viral Infectious Diseases and Gene Expression in Insects
2019 - Wiley | Pest Management Science
Marina V. Backer, Joseph M. Backer, Prakash Chinnaiyan,
... only known substrate of the proteolytic A subunit (SubA) of a bacterial AB(5) toxin, and the selective SubA-induced cleavage of GRP78 leads to massive cell death. Targeted delivery of SubA into cancer cells via specific receptor-mediated endocytosis ... suitable strategy for assaulting tumor cells. We fused SubA to epidermal growth factor (EGF), whose receptor (EGFR) ... tumor cells, and demonstrated that the resulting EGF-SubA immunotoxin is an effective killer of EGFR-positive ... because of its unique mechanism of action, EGF-SubA synergizes with UPR-inducing drugs, which opens a ...
Tópico(s): Transgenic Plants and Applications
2011 - Academic Press | Methods in enzymology on CD-ROM/Methods in enzymology
David Galloway, Ethan A. Mezoff, Wujuan Zhang, Melissa Byrd, Conrad R. Cole, Inmaculada Aban, Samuel A. Kocoshis, Kenneth D.R. Setchell, James E. Heubi,
... determined qualitative and quantitative serum unconjugated bile acid (SUBA) levels among children with history of intestinal failure ( ... at enrollment and following treatment for SBBO. Results : SUBA concentrations were elevated in IF subjects (median 1. ... 05–0.18 μM, P = 0.001). Among SUBA, chenodeoxycholic acid (CDCA) was significantly elevated in subjects ( ... 0.017). Treatment for SBBO did not alter SUBA concentration. Conclusions : SUBA concentrations are elevated in children with history of ... IF subjects with negative aspirates. The determination of SUBA concentration may be a useful surrogate to small ...
Tópico(s): Gastroesophageal reflux and treatments
2018 - Wiley | Journal of Parenteral and Enteral Nutrition
Jérôme Le Nours, Adrienne W. Paton, Emma Byres, Sally Troy, Brock P. Herdman, Matthew D. Johnson, James C. Paton, Jamie Rossjohn, Travis Beddoe,
... the cytosol, cleaves the endoplasmic reticulum chaperone BiP. SubA interacts with SubB in a similar manner to ... The structure revealed that the active site of SubA is not occluded by the B-pentamer, and ... does not enhance or inhibit the activity of SubA. Structure-based sequence comparisons with other AB5 toxin ... the cytosol, cleaves the endoplasmic reticulum chaperone BiP. SubA interacts with SubB in a similar manner to ... The structure revealed that the active site of SubA is not occluded by the B-pentamer, and ...
Tópico(s): Bacterial Genetics and Biotechnology
2013 - Elsevier BV | Journal of Biological Chemistry
Junpei Zhang, Wenting Zhang, Feiyang Ji, Jie Qiu, Xiaobo Song, Dechao Bu, Gang Pan, Qingguo Ma, Jiaxin Chen, Ruimin Huang, Yingying Chang, Dong Pei,
... the walnut genome (dividing into two sub-genomes – subA and subB in this work; Figure 1c). A ... of 11 938 (between red bayberry and walnut subA) and 7978 (between red bayberry and walnut subB) ... J. regia, 7530 cases with singletons retained in subA and 3204 retained in subB, meaning more than ... or no expression pattern correlations between copies in subA and subB, suggesting the duplicates of each other ... in plant senescence; Figure 1h), of which the subA copy were normally expressed in immature fruit and ...
Tópico(s): Genomics and Phylogenetic Studies
2020 - Wiley | Plant Biotechnology Journal
Blake Nield, Stephen Larsen, Sebastiaan J. van Hal,
Abstract Background SUper BioAvailability-itraconazole (SUBA®-itraconazole) was introduced into Australia in April 2014 as a substitute for standard itraconazole on the basis of improved bioavailability, tolerance ... and tolerability of a standard prophylactic dose of SUBA®-itraconazole. Results A total of 74 patients were ... only a single event was directly attributable to SUBA®-itraconazole, resulting in change of prophylactic agent. Conclusions SUBA®-itraconazole achieved rapid therapeutic trough concentrations, was associated ...
Tópico(s): Oral health in cancer treatment
2019 - Oxford University Press | Journal of Antimicrobial Chemotherapy
Yanxun Xu, Lorenzo Trippa, Peter Müller, Yuan Ji,
... usually unpredictable. To address these issues, we propose SUBA, subgroup-based adaptive designs that simultaneously search for ... course of the trial. The main features of SUBA include the continuous reclassification of patient subgroups based ... based on posterior predictive probabilities. We compare the SUBA design with three alternative designs including equal randomization, ... probit regression. In simulation studies we find that SUBA compares favorably against the alternatives.
Tópico(s): Gene expression and cancer classification
2014 - Springer Science+Business Media | Statistics in Biosciences
Rupa Ray, Gustaaf G. de Ridder, Jerry P. Eu, Adrienne W. Paton, James C. Paton, Salvatore V. Pizzo,
... effect of Escherichia coli subtilase cytoxin catalytic subunit (SubA) on GRP78. We report that SubA specifically cleaves cell-surface GRP78 on HepG2, 1- ... have lower amounts of cleaved cell-surface GRP78. SubA has no effect on Hep3B and PC3 cells. ... fragment is released into the culture medium by SubA treatment, and COOH-terminal domain signal transduction is ... signal transduction occurring upon COOH-terminal antibody ligation. SubA is a powerful tool to specifically probe the ...
Tópico(s): Toxin Mechanisms and Immunotoxins
2012 - Elsevier BV | Journal of Biological Chemistry
Joseph M. Backer, Arcadius V. Krivoshein, Carl V. Hamby, John Pizzonia, Kenneth S. Gilbert, Yonaton S. Ray, Harrison Brand, Adrienne W. Paton, James C. Paton, Marina V. Backer,
... only known substrate of the proteolytic A subunit (SubA) of a novel bacterial AB5 toxin. Here, we ... an engineered fusion protein, epidermal growth factor (EGF)-SubA, combining EGF and SubA, is highly toxic to growing and confluent epidermal ... cleavage of GRP78/BiP. Systemic delivery of EGF-SubA results in a significant inhibition of human breast ... prostate tumor xenografts in mouse models. Furthermore, EGF-SubA dramatically increases the sensitivity of cancer cells to ...
Tópico(s): Microbial Inactivation Methods
2009 - Elsevier BV | Neoplasia
Sandeep Singh, Maurice W.J. de Ronde, M. G. M. Kok, Marcel A.M. Beijk, Robbert J. de Winter, Allard C. van der Wal, Brigitte M. Sondermeijer, Joost C.M. Meijers, Esther E. Creemers, Sara‐Joan Pinto‐Sietsma,
... patients with SCAD and UCAD and subclinical atherosclerosis (SubA) and controls, respectively. Result From plaque materials (discovery ... validation in serum from patients with UCAD, SCAD, SubA and controls demonstrated significant upregulation of miR-223- ... 63 (95% CI 11.16 to 38.15), SubA OR 96.10 (95% CI 40.13 to ... miR-499-5p expression was observed across SCAD, SubA and controls. MiR-122-5p was the only ...
Tópico(s): Cancer-related molecular mechanisms research
2020 - BMJ | Open Heart
Lei Liu, Tian‐Yin Cheng, Yan Fen,
... vaccines. However, the entire length of its gene, subA, and its gene expression pattern in different tissues ... extensively. In our study, the full-length of subA in Haemaphysalis flava, Rhipicephalus haemaphysaloides, Rhipicephalus microplus, and Dermacentor sinicus was cloned by RACE–PCR. The subA expression pattern was analyzed further in H. flava ... PCR. We found that the full-length of subA in H. flava, R. haemaphysaloides, R. microplus, and ... and two hypervariable regions, with no signal peptide. SubA expression in female H. flava of different blood- ...
Tópico(s): Venomous Animal Envenomation and Studies
2016 - Springer Science+Business Media | Experimental and Applied Acarology
... the level of origin of the subclavian artery (SubA), in agreement with earlier observations made by Hochstetter ... name of proatlantal artery and confirmed that the SubA was associated with the sixth ISA rather than ... of the supreme intercostal artery (SIA). If the SubA derives from the sixth cervical ISA (ISA 6), ... of the ISA most commonly associated with the SubA as the sixth ISA, but they also emphasize ...
Tópico(s): Intracranial Aneurysms: Treatment and Complications
2014 - Wiley | The Anatomical Record
José A. Orden, Pilar Horcajo, Ricardo de la Fuente, Josï¿ ⁄ A. Ruiz-Santa-Quiteria, Gustavo Domínguez‐Bernal, Javier Carriï¿ ⁄ n,
... is encoded by two closely linked, cotranscribed genes ( subA and subB ). In this study, we investigated the ... different variants of subAB . We therefore sequenced the subA gene in 12 strains and showed that the subA gene in most of the subAB -positive VTEC ... to that in the 98NK2 strain, while the subA gene in most of the subAB -positive VTEC ...
Tópico(s): Bacteriophages and microbial interactions
2011 - American Society for Microbiology | Applied and Environmental Microbiology
Samuel M. Thumbi, Joseph Owino Junga, Reuben Oyoo Mosi, Francis McOdimba,
... and 59 animals randomly selected from Teso and Suba districts respectively were screened for trypanosomes using PCR ... detected.Trypanosome prevalence of 41% and 29% in Suba and Teso districts respectively was observed. T. vivax ... of T. brucei infections (12%) were observed in Suba, a known sleeping sickness foci compared with 2% ...
Tópico(s): Viral Infections and Vectors
2010 - BioMed Central | BMC Research Notes
Joshua L. Heazlewood, Robert E. Verboom, Julian Tonti‐Filippini, Ian Small, A. Harvey Millar,
... bring these various data sources together to build SUBA, a SUBcellular location database for Arabidopsis proteins. The localisation data in SUBA encompasses 10 distinct subcellular locations, >6743 non-redundant ... for 51% of Arabidopsis expressed sequence tags. The SUBA database provides a powerful means by which to ...
Tópico(s): Advanced Proteomics Techniques and Applications
2006 - Oxford University Press | Nucleic Acids Research
Begoña Carrasco, M. Castillo Cozar, Rudi Lurz, Juan C. Alonso, Silvia Ayora,
... recO , Δ recR , recH , Δ recS , and Δ subA cells did not correlate with a chromosomal segregation ... agents. The Δ sms (Δ radA ) and Δ subA mutations partially suppress the DNA repair defect in ... cells. The Δ sms (Δ radA ) and Δ subA mutations partially suppress the DNA repair defect of ... towards noncrossovers and that (ii) Sms (RadA) and SubA proteins might play a role in the stabilization ...
Tópico(s): DNA and Nucleic Acid Chemistry
2004 - American Society for Microbiology | Journal of Bacteriology
Z. Stavreva, D. Zeidler, Matthias Plötner, K. Drescher,
... been performed. The IC 1000 and IC 1000/SUBA IV polishing pads were compared with regard to ... the CMP process. Polishing with the IC 1000/SUBA IV pad, a better uniformity and higher polish ... planarity, but it is also essential that the SUBA IV bottom layer of the IC 1000/SUBA IV polishing pad improves the resilience and compressibility ...
Tópico(s): Integrated Circuits and Semiconductor Failure Analysis
1997 - Elsevier BV | Applied Surface Science