Hilary Kerr, Anthony Harris, Tunku Varadarajan, Gowrie, Chairman, Jon Ashworth, Raymond Snoddy Media Editor, Andrew Tessler, Alexandra Frean, Kathy Lipari, Sam Kiley Africa Correspondent, Michael Binyon and David Watts, Peter Beesley, Richard Ford, Home Correspondent, David Hands and Mark Souster, Paul Hoggart, John Howkins, Martin Fletcher, Chief Ireland Correspondent, and Richard Evans, P. Facey, Philip Howard, Carol Midgley, Hilary Finch, William Ward, Geoffrey Marshall, Ian Murray, Angela Court, Michael Binyon, Ron West, Oliver Holt Football Correspondent, Michael Temple, Raymond Snoddy, Gerald Davies, Felicity Collier, Joe Joseph, Robert Sheehan, Bridge Correspondent, Jason Nissè and Raymond Snoddy, John Clarke, Christopher Ball, Nicholas Watt, Political Correspondent, Dominic Walsh, Raymond Keene Chess Correspondent, Paul Collins, Peter Waymark, Stephen Farrell, Robin Young, Ian Murray, Medical Correspondent, Rachel Kelly, Property Correspondent, John O'Leary, Adrian Lee and Tim Jones, Charles Bremner, Philip Webster and Martin Fletcher, Stephen Howd, Deborah Collcutt, Jason Nissè, Peter Barnard, Luke Clancy, Simon Tait, Jasper Gerard, Valerie Elliott Whitehall Editor, Peter Tron, Russell Kempson, Daniel McGrory, Joe McNAMME, Meg Carter, Roger Morton, Martin Fletcher, Chief Ireland Correspondent, Marit Hargie, John Hopkins, Paul Sexton, Simon de Bruxelles, Richard Miles, Banking Correspondent, Adam Jones, Marcus Binney, Raymond Keene, Frances Gibb, Legal Correspondent, Paul Wilkinson, Stefano Hatfield, Pelham B. Allen, Chief Executive, Richard Evans, Nigel Hawkes, Carl Mortished, International Business Editor, Bronwen Maddox, Deborah Brett, Oliver Holt, Richard Owen, Sydney Friskin and Cathy Harris, Stewart Tendler, David Hands Rugby Correspondent, John Allison, Christopher Thomas, Roger Sinnett, John Lloyd, Giles Whittell, Christopher Walker, James Pringle, Chris Parker, Jane Shilling, Simon De Bruxelles, Brian MacArthur, Gerald Larner, Matthew Parris, Richard Evans Racing Correspondent, Chris McGrath, Caitlin Moran, Christopher Evans, Walter Gammie, Peter Riddell, Ben MacIntyre, Alan Lee Cricket Correspondent, Richard Beeston, Brian Glanville, Jason Cowley, David Sinclair, Fraser Nelson, Tim Jones, Mark Henderson, Michael Horsnell, Gillian Harris, Chris Ayres, Marianne Curphey Insurance Correspondent, Benedict Nightingale, Tom Rhodes, Sarah Cunningham Retail Correspondent, Frances Gibb Legal Correspondent, Julian Muscat Tennis Correspondent, Michael R. Taylor, Richard Morrison, Michael Evans, Alasdair Murray, Robert Whymant, Richard Miles Banking Correspondent, Colin McQuillan, Alasdair Murray, Economics Correspondent, Christopher Irvine, Christine Buckley, Industrial Correspondent, Virginia Matthews,
... investment costs Tate & Lyle wins us approval for sucralose Business Roundup BWI sees profits slip Biffa makes ...
1998 - Gale Group | TDA
David A. Young, Willis H. Bowen,
Sucralose (1',4',6' trideoxy-trichloro-galactosucrose) is a nontoxic, intensely sweet sucrose derivative that has been ... to determine whether certain oral bacteria could utilize sucralose. Sucralose, as a sole carbon source, was unable to ... strains of oral bacteria and dental plaque. When sucralose was incorporated into a liquid medium containing glucose ... with controls. The incorporation of 126 mmol/L sucralose into glucose agar medium caused total inhibition of ... sanguis Challis, Streptococcus salivarius, and Actinomyces viscosus WVU627. Sucralose had no effect on IPS production. Sucralose was ...
Tópico(s): Probiotics and Fermented Foods
1990 - SAGE Publishing | Journal of Dental Research
... the persistence of these additives. Two, acesulfame and sucralose, were remarkably resistant to treatment by conventional sewage ... sulfame exceeded 2 μg/L, whereas concentrations of sucralose, cyclamate, and saccharin were an order of magnitude ... 2009 for publication in Marine Chemistry—also show sucralose in Arizona wastewater treatment plant effluent and several ... waters off the southeastern United States.Acesulfame and sucralose, which is sold in the United States as ... agree there's little risk that acesulfame and sucralose in drinking water will cause human health problems. ...
Tópico(s): Dye analysis and toxicity
2009 - National Institute of Environmental Health Sciences | Environmental Health Perspectives
Jing Ma, Max Bellon, Judith M. Wishart, Richard L. Young, L. Ashley Blackshaw, Karen L. Jones, Michael Horowitz, Christopher K. Rayner,
... homeostasis in both health and diabetes. In mice, sucralose, an artificial sweetener, stimulates GLP-1 release via ... 500 ml (∼290 mosmol/l), 2) 80 mg sucralose in 500 ml normal saline (∼300 mosmol/l, 0.4 mM sucralose), 3) 800 mg sucralose in 500 ml normal saline (∼300 mosmol/l, 4 mM sucralose), and 4) 500 ml normal saline (∼300 mosmol/ ... 0.0001) but not after either load of sucralose or saline. Gastric emptying of sucrose was slower ... there were no differences in t 50 between sucralose 0.4 mM (73.7 ± 3.1 min) ... 3.1 min) and saline. We conclude that sucralose, delivered by intragastric infusion, does not stimulate insulin, ...
Tópico(s): Neuropeptides and Animal Physiology
2009 - American Physiological Society | AJP Gastrointestinal and Liver Physiology
... for the direct, simultaneous determination of acesulfame and sucralose in oral electrolyte maintenance solution (OEMS). Analyte separation ... second wavelength, 214 nm, was used to check sucralose peak purity; 20 microL OEMS was injected without ... all residuals < 0.5%, for both acesulfame and sucralose). Spike recoveries for OEMS samples prepared at 3 ... and from 97.9 to 102.3% for sucralose. In a second assessment of method accuracy, the ... methods: acesulfame (LC/UV at 230 nm) and sucralose (anion exchange-pulsed amperometric detection). Results for the ...
Tópico(s): Analytical Chemistry and Chromatography
2003 - Oxford University Press | Journal of AOAC International
Gertrud E. Morlock, Leonard Schuele, Sebastian Grashorn,
Sucralose, a persistent chlorinated substance used as sweetener, can already be found in waste water, and various countries focused on the release of sucralose into the aquatic environment. A quantitative high-performance ... orthogonal to existing methods, was developed to analyze sucralose in water. After sample preparation, separation of up ... Due to the weak native UV absorption of sucralose (≤200 nm), various post-chromatographic derivatization reactions were compared to selectively detect sucralose in effluent and surface water matrices. Thereby p- ...
Tópico(s): Molecular Sensors and Ion Detection
2010 - Elsevier BV | Journal of Chromatography A
Morten Hjorth, Joan H. Hansen, Lionel Camus,
The potential effects of sucralose on the Arctic copepods Calanus finmarchicus and Calanus glacialis were studied in Disko Bay, Greenland. Sucralose is a non-calorie sweetener and chlorine derivate ... containing three chlorine atoms. Scandinavian screening studies of sucralose in 2007, revealed sucralose in all effluent samples. To investigate whether sucralose is harmful to the Arctic aquatic ecosystems, possible ... concentrations (0–50,000 ng · L−1) of sucralose, which spans the range of concentrations found in ...
Tópico(s): Toxic Organic Pollutants Impact
2010 - Taylor & Francis | Chemistry and Ecology
... and Krymchantowski,3 all regarding the potential for sucralose as a migraine trigger. While it is important ... hundreds of millions of exposures to products containing sucralose during more than 15 years these products have ... There are abundant data demonstrating the safety of sucralose.4-12 In assessing the overall safety profile of sucralose, one cannot ignore the extensive data showing that sucralose is well tolerated and safe for use in ... intakes.4-8 Clinical studies similarly show that sucralose is as well tolerated as placebo.9, 10, ...
Tópico(s): Migraine and Headache Studies
2007 - Wiley | Headache The Journal of Head and Face Pain
Heather Ford, Véronique Peters, Niamh Martin, Michelle Sleeth, M A Ghatei, Gary Frost, Stephen R. Bloom,
... L-cells throughout the gastrointestinal tract. Application of sucralose (a non-calorific, non-metabolisable sweetener) to L- ... healthy subjects to investigate whether oral ingestion of sucralose could stimulate L-cell-derived GLP-1 and ... order. Subjects consumed 50 ml of either water, sucralose (0.083% w/v), a non-sweet, glucose-polymer matched for sweetness with sucralose addition (50% w/v maltodextrin+0.083% sucralose) or a modified sham-feeding protocol (MSF=oral stimulation) of sucralose (0.083% w/v). Appetite ratings and plasma ...
Tópico(s): Diet, Metabolism, and Disease
2011 - Springer Nature | European Journal of Clinical Nutrition
Lindsay Soh, Kristin A. Connors, Bryan W. Brooks, Julie B. Zimmerman,
The degradation and partitioning of sucralose during exposure to a variety of environmental and advanced treatment processes (ATP) and the effect of sucralose on indicator plant species were systematically assessed. Bench ... ozonation, and microbial processes indicating that breakdown of sucralose will likely be slow and incomplete leading to accumulation in surface waters. Further, the persistence of sucralose was compared to suggested human tracer compounds, caffeine and acesulfame-K. In comparison sucralose exhibits similar or enhanced characteristics pertaining to persistence, ...
Tópico(s): Environmental Chemistry and Analysis
2011 - American Chemical Society | Environmental Science & Technology
César I. Torres, Smitha Ramakrishna, Chao‐An Chiu, Katherine G. Nelson, Paul Westerhoff, Rosa Krajmalnik‐Brown,
Sucralose, a chlorinated carbohydrate, is used as an artificial sweetener in more than 80 countries and in ... been done on the degradation and fate of sucralose in municipal wastewater treatment plants (WWTPs). We collected ... surface waters in Arizona, United States. The average sucralose concentration of seven WWTP effluents was 2,800 ± ... ng/L. Similarly, surface waters in Arizona contained sucralose at concentrations up to 300 ± 30 ng/L, which corroborates sucralose discharge from WWTPs into the environment. Biological degradation ...
Tópico(s): Dye analysis and toxicity
2011 - Mary Ann Liebert, Inc. | Environmental Engineering Science
Gregory C. Loney, Ann‐Marie Torregrossa, J. Cecil Smith, Anthony Sclafani, Lisa A. Eckel,
... variability in their preference for the artificial sweetener sucralose over water. While some rats can be classified as sucralose preferrers (SP), as they prefer sucralose across a broad range of concentrations, others can be classified as sucralose avoiders (SA), as they avoid sucralose at concentrations above 0.1 g/L. Here, ... tests involving water and an ascending series of sucralose concentrations, that this variability in sucralose preference is robust across sex, stage of the ... approximately 35-65%. This bimodal behavioral response to sucralose appears to be driven by taste because rats ...
Tópico(s): Olfactory and Sensory Function Studies
2011 - Oxford University Press | Chemical Senses
Louis M. Steinberg, Folarin Odusola, Irwin D. Mandel,
Our earlier work demonstrated that the sweetener sucralose, C12H19CI3O8, mixed with water had no effect on intraoral plaque pH. The current study compared the effect on resting plaque pH of sucralose to sucrose when these sweeteners were used in ... using coffee as vehicle with: (1) sucrose; (2) sucralose; (3) sucralose plus maltodextrin (SM); (4) sucralose plus dextrose and maltodextrin (SMD), and (5) no ... of AUC in the various groups showed that sucralose with coffee had no statistically significant impact on ...
Tópico(s): Oral and gingival health research
1996 - Karger Publishers | Caries Research
The preference of female Sprague–Dawley rats for sucralose, a non-nutritive sweetener derived from sucrose, was ... the rats displayed weak or no preferences for sucralose (0.25–4 g/l) over water but ... over water and saccharin (1 g/l) over sucralose (0.5 g/l). The rats also preferred ... sucrose mixture to sucrose, but sucrose to a sucralose + sucrose mixture. There were marked individual differences in sucralose preferences: about half the rats preferred sucralose to water at some concentrations while most remaining ...
Tópico(s): Regulation of Appetite and Obesity
2004 - Oxford University Press | Chemical Senses
Steve Mann, M.M Yuschak, S.J.G Amyes, P Aughton, J. Paul Finn,
The potential carcinogenicity of sucralose was evaluated by feeding groups of 52 male and 52 female CD-1 mice a diet containing sucralose at 0.3% (3000 ppm), 1.0% (10, ... male and 72 female mice received diet without sucralose and served as controls. Week 1 achieved doses ... low-dose males and high-dose females, respectively. Sucralose had no adverse effect on survival. No significant changes attributable to sucralose were found in the clinical condition or behaviour ... weight gain at the highest dietary concentration of sucralose was significantly less than that of the control ...
Tópico(s): Biochemical Analysis and Sensing Techniques
2000 - Elsevier BV | Food and Chemical Toxicology
I M Baird, N. W. Shephard, Russell J. Merritt, Gavin Hildick‐Smith,
... dose study conducted in eight subjects, in which sucralose was administered at doses of 1, 2.5, ... days. In the second study, subjects consumed either sucralose (n=77) or fructose (50 g/day) (n=31) twice daily in single blind fashion. Sucralose dosage levels were 125 mg/day for weeks ... experiences or clinically detectable effects were attributable to sucralose in either study. Similarly, haematology, serum biochemistry, urinalysis and EKG tracings were unaffected by sucralose administration. In the 13-week study, serial slit ...
Tópico(s): Polyamine Metabolism and Applications
2000 - Elsevier BV | Food and Chemical Toxicology
Steve Mann, M.M Yuschak, S.J.G Amyes, P Aughton, J. Paul Finn,
The chronic toxicity and potential carcinogenicity of sucralose was evaluated by exposing Sprague-Dawley rats to dietary concentrations of this low-calorie sweetener both in utero and for up to 104 ... 000 ppm) or 3.0% (30,000 ppm) sucralose. Each treatment group comprised 30 male and 30 ... surviving rats were killed following 78 weeks of sucralose administration. In the carcinogenicity phase of this investigation, ... male and 50 female rats were administered dietary sucralose at concentrations of 0% (control 1), 0% (control ...
Tópico(s): Olfactory and Sensory Function Studies
2000 - Elsevier BV | Food and Chemical Toxicology
John W. Kille, W. C. L. Ford, P. A. McAnulty, J.M. Tesh, F.W. Ross, Christopher Willoughby,
Certain chlorine-substituted sugars with chemical similarities to sucralose have been demonstrated previously to diminish or inhibit ... 1978a). In order to investigate this potential for sucralose, epididymal spermatozoa were recovered from rats exposed in ... 6-CG, 24 mg/kg/day, positive control), sucralose (500 mg/kg/day, over 300 times the ... daily intake), or a 6′-substituted isomer of sucralose, trichloro de-oxy sucrose (TCDS, 100 mg/kg/day, a potential trace impurity in commercial sucralose); distilled water served as the negative control. After ...
Tópico(s): Insect and Pesticide Research
2000 - Elsevier BV | Food and Chemical Toxicology
Sucralose has been regarded as an emerging pollutant with growing concerns owing to its environmental persistence and ... the environment. In this study, complete and efficient sucralose biodegradation was achieved by enriched consortia seeded with activated sludge. In the enrichments with sucralose as the sole carbon source, 73 % of the ... a maximum degradation rate of 3.87 mg sucralose/g VSS·h−1, coupling with the release of three chloride ions of sucralose. Additionally, five biotransformation products, namely TP-409N, TP- ...
Tópico(s): Microbial Community Ecology and Physiology
2000 - Elsevier BV | Food and Chemical Toxicology
A.-M. Torregrossa, Gregory C. Loney, J. Cecil Smith, Lisa A. Eckel,
Sucralose avoiding rats detect a bitter-like taste quality in concentrations of sucralose that are strongly preferred over water by sucralose preferring rats. Here, we investigated whether sucralose preferrers (SP) also detect a bitter-like quality in sucralose that may be masked by an increased perception of sucralose's sweet-like quality. A microstructural analysis of sucralose intake revealed that, at concentrations they avoided in preference tests, sucralose avoiders (SA) consumed smaller and fewer bouts of ...
Tópico(s): Regulation of Appetite and Obesity
2014 - Elsevier BV | Physiology & Behavior
Bikram Subedi, Kurunthachalam Kannan,
... mass loadings, removal efficiencies, and environmental emission of sucralose, saccharin, aspartame, and acesulfame were determined based on ... 0.13 (aspartame) to 29.4 μg/L (sucralose) in wastewater influent, 0.49 (aspartame) to 27.7 μg/L (sucralose) in primary influent, 0.11 (aspartame) to 29.6 μg/L (sucralose) in effluent, and from 0.08 (aspartame) to 0.65 μg/g dw (sucralose) in sludge. Aspartame was found in 92% of ... aspartame (50.4%) > acesulfame (10.9%) > saccharin and sucralose (0.8%). The sorption coefficients of ASWs ranged ...
Tópico(s): Advanced Chemical Sensor Technologies
2014 - American Chemical Society | Environmental Science & Technology
Omar A A AlDeeb, Hoda Mahgoub, Nagwa H. Foda,
Sucralose is a nonnutritive, zero-calorie artificial sweetener. It is a chlorinated sugar substitute that is about ... in baked and fried foods. The FDA approved sucralose in 1998. This review presents a comprehensive profile for sucralose including physical, analytical, and ADME profiles and methods ... for X-ray powder diffraction and DSC of sucralose are recorded and presented. The authors also recorded ... spectral assignments is provided. The analytical profile of sucralose covered the compendial methods, spectroscopic, and different chromatographic ...
Tópico(s): Analytical Chemistry and Chromatography
2013 - Elsevier BV | Profiles of drug substances, excipients, and related methodology
Sudha Rani Batchu, Natalia Quinete, Venkata R. Panditi, Piero R. Gardinali,
Sucralose has gained popularity as a low calorie artificial sweetener worldwide. Due to its high stability and persistence, sucralose has shown widespread occurrence in environmental waters, at ... with rather high detection limits (direct injection) for sucralose analysis. This study described a faster and sensitive analytical method for the determination of sucralose in environmental samples.An online SPE-LC-MS/MS method was developed, being capable to quantify sucralose in 12 minutes using only 10 mL of ...
Tópico(s): Pharmaceutical and Antibiotic Environmental Impacts
2013 - BioMed Central | Chemistry Central Journal
Arthur Omran, Gregory A. Ahearn, Doria F. Bowers, Janice Swenson, Charles Coughlin,
Sucralose was developed as a low cost artificial sweetener that is nonmetabolizable in humans. Sucralose can withstand changes in pH and temperature and ... Environmental isolates were cultured in the presence of sucralose looking for potential sucralose metabolism or growth acceleration responses. Sucralose was found to be nonnutritive and demonstrated bacteriostatic ... inhibition was directly proportional to the concentration of sucralose exposure, and the amount of the growth inhibition ... decrease in sucrose uptake by bacteria exposed to sucralose. We have determined that sucralose inhibits invertase and ...
Tópico(s): Aquaculture disease management and microbiota
2013 - Hindawi Publishing Corporation | Journal of Toxicology
Helen N. Saada, Nefissa H. Mekky, Hassan A. Eldawy, Abeer F. Abdelaal,
... people that might take a large amount of sucralose, are diabetic people who are attempting to modify ... this study is to evaluate the impact of sucralose; an artificial sweetener derived from sucrose, at a ... glucose levels ≥250 mg/dl were considered diabetics. Sucralose was dissolved in water and administered to rats ... for 6 weeks. Control: rats received distilled water, Sucralose: rats received sucralose, Diabetic: diabetic rats received distilled water, Diabeticrats + Sucralose: diabetic rats received sucralose. The administration of sucralose ...
Tópico(s): Biochemical effects in animals
2013 - Scientific Research Publishing | Food and Nutrition Sciences
Susan S. Schiffman, Kristina I. Rother,
Sucralose is a synthetic organochlorine sweetener (OC) that is a common ingredient in the world's food supply. Sucralose interacts with chemosensors in the alimentary tract that ... sweet taste sensation and hormone secretion. In rats, sucralose ingestion was shown to increase the expression of ... in first-pass drug metabolism. The effect of sucralose on first-pass drug metabolism in humans, however, has not yet been determined. In rats, sucralose alters the microbial composition in the gastrointestinal tract ( ...
Tópico(s): Advanced Chemical Sensor Technologies
2013 - Taylor & Francis | Journal of Toxicology and Environmental Health Part B
W. D. Robertson, Dale R. Van Stempvoort, John Spoelstra, Susan Brown, Sherry L. Schiff,
The artificial sweetener sucralose has been in use in Canada and the US since about 2000 and in the EU since 2003, and ... wastewater. In this study, longer-term persistence of sucralose was examined in groundwater by undertaking a series ... year period from 2008 to 2014. A shrinking sucralose plume in 2014, compared to earlier sampling, during this period when sucralose use was likely increasing, provides clear evidence of degradation. However, depletion of sucralose from a mean of 40 μg/L in ... at six other sites in Canada, revealed that sucralose was present in all samples of septic tank ...
Tópico(s): Biochemical Analysis and Sensing Techniques
2015 - Elsevier BV | Water Research
Allison C. Sylvetsky, Viviana Bauman, Jenny E. Blau, H. Martin Garraffo, Peter J. Walter, Kristina I. Rother,
... measure concentrations of the commonly used artificial sweetener sucralose, following ingestion of doses reflecting a range of ... 0 mg (control), 68, 170, or 250 mg sucralose (equivalent to 1–4 diet sodas). A second ... consumed 355 mL Diet Rite Cola™ (68 mg sucralose and 41 mg acesulfame-potassium (ace-K)) or 68 mg sucralose and 41 mg ace-K in seltzer. Beverages ... test. Eleven children consumed 0 or 68 mg sucralose in 240 mL water, in an identical study ... before beverage ingestion and serially for 120 min. Sucralose doses (corrected for weight) resulted in similar plasma ...
Tópico(s): Advanced Chemical Sensor Technologies
2016 - Taylor & Francis | Toxicological & Environmental Chemistry Reviews
Nimesh Shukla, Enrico Pomarico, Cody J. S. Hecht, Erika A. Taylor, Majed Chergui, Christina M. Othon,
Sucralose is a commonly employed artificial sweetener that appears to destabilize protein native structures. This is in ... We have further explored the molecular interactions of sucralose as compared to sucrose to illuminate the origin ... We show that the mode of interactions of sucralose and sucrose in bulk solution differ subtly through ... use of hydration dynamics measurement and computational simulation. Sucralose does not appear to disturb the native state ... concentration increases, or in the thermally stressed state, sucralose appears to differ in its interactions with protein ...
Tópico(s): Protein Structure and Dynamics
2017 - Elsevier BV | Archives of Biochemistry and Biophysics
Ruikang Hu, Lifeng Zhang, Jiangyong Hu,
Sucralose is one of widely used artificial sweeteners, which has been ubiquitously detected in various water sources, ... Although there are some studies on removal of sucralose by advanced oxidation process, limited information, in terms ... influence of pH, humic acid and carbonate on sucralose degradation by ozone, have been studied systematically. The results demonstrated that ozonation of sucralose was initiated by the formation of OH radical. Sucralose could be completely removed with excess O3 at ...
Tópico(s): Pharmaceutical and Antibiotic Environmental Impacts
2017 - Elsevier BV | The Science of The Total Environment