Yu-Jung Lee, Jeong‐Eun Lee, Hyo-Jung Choi, Jung-Suk Lim, Hyun Jun Jung, Moon-Chang Baek, Jørgen Frøkiær, Søren Nielsen, Tae‐Hwan Kwon,
The E3 ubiquitin (Ub)-protein ligases (E3s) play a role as regulators of protein trafficking and degradation. We aimed to integrate the profile of E3s in rat kidney and examine the changes in protein abundance of the selected E3s in response to 1-deamino-8-D-arginine vasopressin (dDAVP) stimulation/withdrawal. Sprague-Dawley rats were infused with vehicle (n = 13), dDAVP for 5 days (n = 13), or dDAVP was withdrawn for periods (15 min, 30 min, 1, 3, 6, 12, or 24 h) after 5-day infusion (n = 46). Total RNA was ...
Tópico(s): Pancreatic function and diabetes
2011 - American Physical Society | AJP Renal Physiology
Kyung Ah Kim, Mi‐Suk Park, Hyun‐Jun Ji, Jun Yong Park, Kwang‐Hyub Han, Myeong‐Jin Kim, Ki Whang Kim,
Purpose To assess whether MR perfusion and diffusion parameters taken before concurrent chemoradiotherapy (CCRT) are useful imaging biomarkers for predicting progression‐free survival (PFS) in patients with hepatocellular carcinoma (HCC). Materials and Methods Twenty patients with locally advanced HCC who had no treatment before CCRT underwent dynamic contrast‐enhanced (DCE) and diffusion‐weighted MRI. Mean values of the volume transfer constant (K trans ), reflex constant (K ep ), extravascular extracellular ...
Tópico(s): Hepatocellular Carcinoma Treatment and Prognosis
2013 - Wiley | Journal of Magnetic Resonance Imaging
Eui-Jung Park, Jung-Suk Lim, Hyun Jun Jung, Eunjung Kim, Ki‐Hwan Han, Tae‐Hwan Kwon,
It has been reported that several proteins [heat shock protein 70 (Hsp70 and Hsc70), annexin II, and tropomyosin 5b] interact with the Ser(256) residue on the COOH terminus of aquaporin-2 (AQP2), where vasopressin-induced phosphorylation occurs for mediating AQP2 trafficking. However, it remains unknown whether these proteins, particularly Hsp70, play a role in AQP2 trafficking. Semiquantitative immunoblotting revealed that renal expression of AQP2 and Hsp70 was significantly increased in water-restricted ...
Tópico(s): Hormonal Regulation and Hypertension
2013 - American Physical Society | AJP Renal Physiology
Mi Suk Noh, Bong‐Hyun Jun, Seong-Yong Kim, Homan Kang, Min‐Ah Woo, Arash Minai‐Tehrani, Ji‐Eun Kim, Jaeyun Kim, Joo‐Young Park, Hwang-Tae Lim, Se Chang Park, Taeghwan Hyeon, Yong-Kweon Kim, Dae Hong Jeong, Jeong Yong Lee, Myung‐Haing Cho,
Bronchioalveolar stem cells (BASCs) play an important role in the development of cancer. To study the characterization of BASCs, their isolation and purification are important. However, the cells are very rare in tissues and the available methods of isolating them are limited. The current study was performed to isolate BASCs in the murine lung using magnetic nanoparticle-based surface-enhanced Raman spectroscopic dots (M-SERS Dots). We used K-rasLA1 mice, a laboratory animal model of non-small cell ...
Tópico(s): Cancer Cells and Metastasis
2009 - Elsevier BV | Biomaterials
Yong-Hyun Kim, Yun Kyung Chung, Chang-Hwan Kim, Eun Suk Nam, Hyun‐Jun Kim, Youngsu Joo,
Dental technicians are exposed to methyl methacrylate(MMA) and hard metal dusts while working, and several cases of hypersensitivity pneumonitis caused by the exposure have been reported. The authors experienced a case of hypersensitivity pneumonitis in a female dental technician who had 10 years' work experience and report the case with clinical evidence.The patient's work, personal, social, and past and present medical histories were investigated based on patient questioning and medical records. ...
Tópico(s): Occupational and environmental lung diseases
2013 - BioMed Central | Annals of Occupational and Environmental Medicine
Sang‐Nam Lee, In‐Suk Choi, Hyun Jun Kim, Eun Jin Yang, Hyun Jin Min, Joo‐Heon Yoon,
Chronic repetitive rounds of injury and repair in the airway lead to airway remodelling, including ciliated cell loss and mucous cell hyperplasia. Airway remodelling is mediated by many growth and differentiation factors including Notch1, which are proteolytically processed by proprotein convertases (PCs). The present study evaluated a novel approach for controlling basal cell-type determination based on the inhibition of PCs. It was found that decanoyl-RVKR-chloromethylketone (CMK), a PC inhibitor, ...
Tópico(s): Neonatal Respiratory Health Research
2016 - Wiley | Journal of Tissue Engineering and Regenerative Medicine
Hyo-Young Kim, Hyo-Jung Choi, Jung-Suk Lim, Eui-Jung Park, Hyun Jun Jung, Yu-Jung Lee, Sang-Yeob Kim, Tae‐Hwan Kwon,
AS160, a novel Akt substrate of 160 kDa, contains a Rab GTPase-activating protein (GAP) domain. The present study examined the role of Akt and AS160 in aquaporin-2 (AQP2) trafficking. The main strategy was to examine the changes in AQP2 translocation in response to small interfering RNA (siRNA)-mediated AS160 knockdown in mouse cortical collecting duct cells (M-1 cells and mpkCCDc14 cells). Short-term dDAVP treatment in M-1 cells stimulated phosphorylation of Akt (S473) and AS160, which was also seen ...
Tópico(s): Ion channel regulation and function
2011 - American Physical Society | AJP Renal Physiology
Jong Won Hong, Tai Suk Roh, Han‐Su Yoo, Hyun Jun Hong, Hong‐Shik Choi, Hang‐Seok Chang, Cheong S. Park, Young Seok Kim,
Management of unrecognized recurrent laryngeal nerve injury typically entails delayed phonosurgical intervention and laryngeal reinnervation, but in cases of recognized injury, nerve anastomosis has been considered standard management. However, the well-organized outcome analysis of nerve anastomosis has been insufficient. We performed immediate direct anastomosis of recurrent laryngeal nerves injured during surgery for thyroid cancer, and subsequent patient outcomes were analyzed.A total 14 patients ...
Tópico(s): Tracheal and airway disorders
2013 - Wiley | The Laryngoscope
Bong‐Hyun Jun, Mi Suk Noh, Jaeyun Kim, Gunsung Kim, Homan Kang, Min‐Soo Kim, Young‐Tae Seo, Jongho Baek, Jong‐Ho Kim, Ju‐Young Park, Seong-Yong Kim, Yong‐Kweon Kim, Taeghwan Hyeon, Myung‐Haing Cho, Dae Hong Jeong, Jeong Yong Lee,
In this study, surface-enhanced Raman spectroscopy (SERS)-encoded magnetic nanoparticles (NPs) are prepared and utilized as a multifunctional tagging material for cancer-cell targeting and separation. First, silver-embedded magnetic NPs are prepared, composed of an 18-nm magnetic core and a 16-nm-thick silica shell with silver NPs formed on the surface. After simple aromatic compounds are adsorbed on the silver-embedded magnetic NPs, they are coated with silica to provide them with chemical and physical ...
Tópico(s): Biosensors and Analytical Detection
2009 - Wiley | Small
Bong‐Hyun Jun, Mi Suk Noh, Gunsung Kim, Homan Kang, Jong-Ho Kim, Woo‐Jae Chung, Min‐Soo Kim, Yong-Kweon Kim, Myung‐Haing Cho, Dae Hong Jeong, Jeong Yong Lee,
This article presents a prototype of a surface-enhanced Raman spectroscopy (SERS)-encoded magnetic bead of 8 μm diameter. The core part of the bead is composed of a magnetic nanoparticle (NP)-embedded sulfonated polystyrene bead. The outer part of the bead is embedded with Ag NPs on which labeling molecules generating specific SERS bands are adsorbed. A silica shell is fabricated for further bioconjugation and protection of SERS signaling. Benzenethiol, 4-mercaptotoluene, 2-naphthalenethiol, and 4- ...
Tópico(s): Advanced biosensing and bioanalysis techniques
2009 - Elsevier BV | Analytical Biochemistry
Hyun‐Jun Kim, Suk-Hun Kim, Seung‐Hwan Chang,
The flexible fixation method is known to provide beneficial conditions for healing bone fractures by allowing appropriate relative movement at the fracture site. Using finite element analysis (FEA), we investigated the healing efficiency of flexible composite bone plates applied to a tibia with diaphyseal oblique fractures. To construct the finite element model, the time-dependent properties of living tissue (callus) were estimated using healing rates that were updated at every healing period using ...
Tópico(s): Orthopedic Infections and Treatments
2011 - Elsevier BV | Composites Part B Engineering
Hyun‐Jun Kim, Suk-Hun Kim, Seung‐Hwan Chang,
The present paper deals with finite element analyses to estimate the healing efficiency of fractured long bones to which various composite bone plates are applied. To estimate the callus modulus according to the healing period, interfragmentary strain theory was used, and the iterative process for updating the newly determined callus properties in every finite element was implemented by a user-defined sub-routine constructed by the Python code. The results of analysis revealed that a composite bone ...
Tópico(s): Structural Behavior of Reinforced Concrete
2011 - Elsevier BV | Composite Structures
Eun Ji Kang, Yu Mi Baek, Eunil Hahm, Sang Hun Lee, Xuan‐Hung Pham, Mi Suk Noh, Dong‐Eun Kim, Bong‐Hyun Jun,
Cyclodextrins (CDs) have beneficial characteristics for drug delivery, including hydrophobic interior surfaces. Nanocarriers with β-CD ligands have been prepared with simple surface modifications as drug delivery vehicles. In this study, we synthesized β-CD derivatives on an Ag-embedded silica nanoparticle (NP) (SiO2@Ag NP) structure to load and release doxorubicin (DOX). Cysteinyl-β-CD and ethylenediamine-β-CD (EDA-β-CD) were immobilized on the surface of SiO2@Ag NPs, as confirmed by transmission electron ...
Tópico(s): Polymer Surface Interaction Studies
2019 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Jeong Hee Yoon, Jeong Min Lee, Ju Hyun Jun, Kyung‐Suk Suh, Philippe Coulon, Joon Koo Han, Byung Ihn Choi,
Tópico(s): Liver Disease and Transplantation
2014 - Springer Nature | Abdominal Radiology
Kyung-Chul Ok, Hyun‐Jun Jeong, Hyun‐Suk Kim, Jin‐Seong Park,
High-performance thin-film transistors (TFTs) based on ZnON channels were fabricated using a dc reactive sputtering method. To improve the photoinduced bias stability, a postannealing process was carried out at a low ambient pressure ( $\sim 100$ mTorr, air ambient) at 250 °C for various annealing times (1–5 h). The transfer characteristics of the postannealed ZnON TFTs exhibited an improved subthreshold swing ranging from 0.60 to 0.42 V/decade. Other transport properties remained similar including a high ...
Tópico(s): Semiconductor materials and devices
2014 - Institute of Electrical and Electronics Engineers | IEEE Electron Device Letters
Hyoung Moon Kim, Kyung-A Byun, Seyeon Oh, Jin Yang, Hyun Jun Park, Moon Suk Chung, Kuk Hui Son, Kyunghee Byun,
It is well-known that increased oxidative stress caused by ultraviolet B (UV-B) radiation induces melanogenesis and activates metalloproteinases (MMPs), which degrade collagen and elastin fibers, leading to decreased skin elasticity. Various antioxidant agents, such as vitamin C and niacinamide, have been evaluated for use as treatments for photoaging or skin pigmentation. In this study, we evaluated the ability of a topical liquid formula of polydeoxyribonucleotide (PDRN), vitamin C, and niacinamide ( ...
Tópico(s): Acne and Rosacea Treatments and Effects
2022 - Multidisciplinary Digital Publishing Institute | Molecules
Jin Hyoung Park, Seong-Ho Moon, Dong Hyun Kang, Hyun Jun Um, Soon-Suk Kang, Jae Yong Kim, Hungwon Tchah,
Purpose: To evaluate the effect of diquafosol on corneal epithelium in a dry eye model using Transwell culture and a scopolamine-induced dry eye rat model. Methods: Desiccation stress induced in an in vitro dry eye model using human corneal epithelial cells was used, and the cells were incubated with or without diquafosol media diluted at 1:100. Reactive oxygen species (ROS) generation was measured using 2′,7′-dichlorofluorescein diacetate (DCFH-DA). Apoptosis was analyzed, and levels of phosphorylated ...
Tópico(s): Advanced Glycation End Products research
2018 - Cadmus Press | Investigative Ophthalmology & Visual Science
Sa‐Hyun Kim, Min Ho Lee, Min Park, Hyun Jun Woo, Yoon Suk Kim, Nagendran Tharmalingam, Woo Duck Seo, Jong‐Bae Kim,
Scope Black rice extract (BRE) contains cyanidin 3‐ O ‐glucoside (C3G), an anthocyanin, as the major component. In this study, we found that BRE inhibits the mRNA and protein expression of genes encoding cytotoxin‐associated protein A ( cagA ) and vacuolating protein A ( vacA ) in Helicobacter pylori 60190 strain. Methods and results We performed RT‐PCR and western blotting to show that BRE inhibits the mRNA and protein expression of SecA. Because SecA is involved in VacA export in bacteria, our result suggests ...
Tópico(s): Veterinary medicine and infectious diseases
2017 - Wiley | Molecular Nutrition & Food Research
Suk-Hee Park, Hyun-Jun Shin, Yong Hwan Kim, Dong‐Yol Yang, Jong‐Chul Lee, Sangyoup Lee,
Novel cost-effective methods for polymeric and metallic nanochannel fabrication have been demonstrated using an electrospun nanofiber array. Like other electrospun nanofiber-based nanofabrication methods, our system also showed high throughput as well as cost-effective performances. Unlike other systems, however, our fabrication scheme provides a pseudo-parallel nanofiber array a few centimeters long at a speed of several tens of fibers per second based on our unique inclined-gap fiber collecting ...
Tópico(s): Microfluidic and Bio-sensing Technologies
2012 - IOP Publishing | Journal of Micromechanics and Microengineering
Y. S. Kim, S. J. Kim, Jai Hoon Yoon, Ki Tae Suk, J. B. Kim, Dong Joon Kim, D. Y. Kim, Hyun-Jun Min, S. H. Park, Woon Geon Shin, K. H. Kim, H. Y. Kim, Gwang Ho Baik,
Aliment Pharmacol Ther 2011; 34: 1098–1105 Summary Background The eradication rates of Helicobacter pylori (H. pylori) using a proton pump inhibitor (PPI)-based triple therapy have declined due to antibiotic resistance worldwide. Aim To compare the eradication rate of the 10-day sequential therapy for H. pylori infection with that of the 14-day standard PPI-based triple therapy. Methods This was a prospective, randomised, controlled study. A total of 409 patients with H. pylori infection were randomly ...
Tópico(s): Veterinary medicine and infectious diseases
2011 - Wiley | Alimentary Pharmacology & Therapeutics
Bong‐Hyun Jun, Gunsung Kim, Mi Suk Noh, Homan Kang, Yong-Kweon Kim, Myung‐Haing Cho, Dae Hong Jeong, Jeong Yong Lee,
Surface-enhanced Raman scattering (SERS) techniques offer a number of advantages in molecular detection and analysis, particularly in terms of the multiplex detection of biomolecules. So far, many new SERS-based substrates and analytical techniques have been reported. For easy understanding, various SERS techniques are classified into the following four categories: adsorption-mediated direct detection; antibody- or ligand-mediated direct detection; binding catalyzed indirect detection; and tag-based ...
Tópico(s): Biosensors and Analytical Detection
2011 - Future Medicine | Nanomedicine
Hyun Jun Jung, Jung-Suk Lim, Hyo-Jung Choi, Mi Suk Lee, Jong-Ho Kim, Sang-Yeob Kim, Soyoun Kim, Eunjung Kim, Tae‐Hwan Kwon,
Internalization of receptor proteins after interacting with specific ligands has been proposed to facilitate siRNA delivery into the target cells via receptor-mediated siRNA transduction. In this study, we demonstrated a novel method of vasopressin V2 receptor (V2R)-mediated siRNA delivery against AQP2 in primary cultured inner medullary collecting duct (IMCD) cells of rat kidney. We synthesized the dDAVP conjugated with nine D-arginines (dDAVP-9r) as a peptide carrier for siRNA delivery. The structure ...
Tópico(s): Pluripotent Stem Cells Research
2012 - Public Library of Science | PLoS ONE
Tae Gyeong Jeon, Do Hoon Kong, Hyun Jun Park, Suk Kim, Won Young Park, Soo Dong Kim, Hong Koo Ha,
Lymphangioma is a rare, benign mesenchymal neoplasm, which is characterized by numerous intercommunicating cystic spaces containing lymphatic fluid. It is considered a congenital disease resulting from the obstruction of regional lymph drainage during the developmental period. Lymphangioma may be focal/unilateral or diffuse/bilateral, and in the latter case, it is referred to as lymphangiomatosis. Here, we report a case of a 38-year-old man with perirenal lymphangiomatosis. The patient's chief complaint ...
Tópico(s): Vascular anomalies and interventions
2014 - Korean Society for Sexual Medicine and Andrology | The World Journal of Men s Health
Young‐Won Kim, Jooseong Kim, Jae-Hyuk Oh, Yoon-Suk Park, Jong-Woo Kim, Kwang‐Il Park, Bai‐Sun Kong, Young-Hyun Jun,
A novel low-power CMOS synchronous counter whose clock-gating logic is embedded into a carry propagation circuit is proposed. The proposed synchronous counter operates with no redundant transitions and requires fewer transistors, minimizing the switching power consumption and silicon area as compared with conventional CMOS synchronous counters. The proposed synchronous counter consisting of 16 bits was fabricated in 0.18-mum CMOS technology. The experimental result indicates that the proposed synchronous ...
Tópico(s): Advancements in PLL and VCO Technologies
2009 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Circuits & Systems II Express Briefs
Hong-Mei Piao, Prabagar Balakrishnan, Hyun‐Jong Cho, Hyun‐Jun Kim, You Sun Kim, Suk‐Jae Chung, Chang‐Koo Shim, Dae‐Duk Kim,
To enhance the solubility and bioavailability of poorly absorbable fexofenadine, microemulsion system composed of oil, surfactant and co-surfactant was developed for intranasal delivery. Phase behavior, particle size, viscosity and solubilization capacity of the microemulsion system were characterized. Histopathology and in vivo nasal absorption of the optimized microemulsion formulations were also investigated in rats. A single isotropic region was found in the pseudo-ternary phase diagrams developed ...
Tópico(s): Surfactants and Colloidal Systems
2010 - Elsevier BV | International Journal of Pharmaceutics
Hyun Jun Cho, Minsub Chung, Min Suk Shim,
Near-infrared (NIR) light-responsive drug delivery systems have gained increasing interest in biomedical applications due to their spatiotemporal and on-demand drug release. This review summarizes recent progress in development of various photo-responsive materials for NIR light-triggered drug release, with particular emphasis on their molecular designs and formulations as well as photo-reaction mechanisms. Various NIR light-responsive materials have been developed mainly by incorporating NIR light- ...
Tópico(s): Luminescence and Fluorescent Materials
2015 - Elsevier BV | Journal of Industrial and Engineering Chemistry
Produção Nacional
Revisado por pares
Ashok Agarwal, Rossella Cannarella, Ramadan Saleh, Ahmed M. Harraz, Hussein Kandil, Gianmaria Salvio, Florence Boitrelle, Shinnosuke Kuroda, Ala’a Farkouh, Amarnath Rambhatla, Armand Zini, Giovanni M. Colpi, Murat Gül, Parviz K. Kavoussi, Taha Abo-Almagd Abdel-Meguid Hamoda, Edmund Ko, Gökhan Çalık, Tuncay Toprak, Germar M. Pinggera, Hyun Jun Park, Ramy Abou Ghayda, Suks Minhas, Gian Maria Busetto, Emre Bakırcıoğlu, Ateş Kadıoğlu, Eric Chung, Giorgio Ivan Russo, Aldo E. Calogero, Rafael F. Ambar, Channa N. Jayasena, Rupin Shah,
Purpose: Purpose: Seminal oxidative stress (OS) is a recognized factor potentially associated with male infertility, but the efficacy of antioxidant (AOX) therapy is controversial and there is no consensus on its utility.Primary outcomes of this study were to investigate the effect of AOX on spontaneous clinical pregnancy, live birth and miscarriage rates in male infertile patients.Secondary outcomes were conventional semen parameters, sperm DNA fragmentation (SDF) and seminal OS. Materials and Methods: ...
Tópico(s): Ovarian function and disorders
2022 - Korean Society for Sexual Medicine and Andrology | The World Journal of Men s Health
Junha Cha, Dahee Kim, Gamin Kim, Jae-Won Cho, Euijeong Sung, Seungbyn Baek, Min Hee Hong, Chang Gon Kim, Nam Suk Sim, Hyun Jun Hong, Jung Eun Lee, Martin Hemberg, Seyeon Park, Sun Och Yoon, Sang‐Jun Ha, Yoon Woo Koh, Hye Ryun Kim, Insuk Lee,
Background Oropharyngeal squamous cell carcinoma (OPSCC) induced by human papillomavirus (HPV-positive) is associated with better clinical outcomes than HPV-negative OPSCC. However, the clinical benefits of immunotherapy in patients with HPV-positive OPSCC remain unclear. Methods To identify the cellular and molecular factors that limited the benefits associated with HPV in OPSCC immunotherapy, we performed single-cell RNA (n=20) and T-cell receptor sequencing (n=10) analyses of tonsil or base of tongue ...
Tópico(s): Head and Neck Cancer Studies
2024 - BMJ | Journal for ImmunoTherapy of Cancer
Yun Kyung Jeon, Sang Soo Kim, Jong Ho Kim, Hyun Jeong Kim, Hyun Jun Kim, Jang Jun Park, Yuen Suk Cho, So Hee Joung, Ji Ryang Kim, Bo Hyun Kim, Sang Heon Song, In Joo Kim, Yong Ki Kim, Young‐Bum Kim,
Background Circulating apolipoprotein J (ApoJ) is closely associated with insulin resistance; however, the effect of exercise on circulating ApoJ levels and the association of ApoJ with metabolic indices remain unknown. Here, we investigated whether a combined exercise can alter the circulating ApoJ level, and whether these changes are associated with metabolic indices in patients with type 2 diabetes mellitus. Methods Postmenopausal women with type 2 diabetes mellitus were randomly assigned into ...
Tópico(s): Diabetes, Cardiovascular Risks, and Lipoproteins
2020 - Korean Diabetes Association | Diabetes & Metabolism Journal
Yoo Suk Kim, Sungryeal Kim, Do‐Yang Park, Hee Won Wu, Gyo‐Seung Hwang, Hyun Jun Kim,
Abstract Obstructive sleep apnea syndrome (OSAS) is a common disease with the prevalence of approximately 10% in general population, and this disease entity is considered to be highly related with the development of cerebrovascular and cardiovascular diseases. In the pathogenesis of cardiovascular disease, maintaining the homeostasis of autonomic nervous system (ANS) is critical. To evaluate the homeostasis of ANS, heart rate variability (HRV) is commonly used. The object of this study was to evaluate ...
Tópico(s): Non-Invasive Vital Sign Monitoring
2015 - Lippincott Williams & Wilkins | Journal of Craniofacial Surgery