L Kager, L Liljeqvist, A.‐S. Malmborg, C. E. Nord, R Pieper,
... combination of ampicillin and a beta-lactamase inhibitor, sulbactam, on colonic bacterial flora was studied in patients ... aerobic and anaerobic bacterial bowel flora. Ampicillin and sulbactam were given intravenously to 21 patients in 500- ... P greater than 0.001) than those of sulbactam. In contrast, at all time intervals, the concentrations of sulbactam in intestinal mucosa were significantly higher than those ... 2 h. After one dose of the antibiotics, sulbactam was detectable in the feces of four patients, ...
Tópico(s): Urinary Tract Infections Management
1982 - American Society for Microbiology | Antimicrobial Agents and Chemotherapy
Ronald N. Jones, Arthur L. Barry, C Thornsberry, Harold W. Wilson,
Three concentrations of the penicillanic acid sulfone, sulbactam were tested in combination with cefoperazone against 632 recent clinical bacterial isolates. Cefoperazone was effective alone (≤16 μg/mL) against 95% of Enterobacteriaceae and combined with 4 μg/mL sulbactam inhibited 99.5% of strains. This coverage of ... cefoperazone-susceptible strains also were markedly decreased by sulbactam (overall MIC90s, 8.0 μg/mL for cefoperazone ... for cefoperazone and 4.0 μg/mL for sulbactam). Sulbactam also expanded the spectrum of cefoperazone against ...
Tópico(s): Antibiotic Use and Resistance
1985 - Oxford University Press | American Journal of Clinical Pathology
B. Fantin, B. Pangon, G. Potel, François Caron, E Vallée, J M Vallois, J. Mohler, A Buré, A. Philippon, C Carbon,
We studied the efficacy of sulbactam, a beta-lactamase inhibitor, in combination with ceftriaxone in vitro and in experimental endocarditis due to an Escherichia coli strain producing ... 10(7) CFU of inoculum per ml, respectively). Sulbactam inhibited the beta-lactamase degradation of ceftriaxone and ... by ceftriaxone with both inocula tested. In vivo, sulbactam (100 mg/kg every 8 h) or ceftriaxone ( ... after a 4-day therapy. The addition of sulbactam to ceftriaxone (15 mg/kg) or to the ... vegetation greater than that produced by therapy without sulbactam. The sulbactam-ceftriaxone (30 mg/kg) combination produced ...
Tópico(s): Antimicrobial Resistance in Staphylococcus
1990 - American Society for Microbiology | Antimicrobial Agents and Chemotherapy
The parenteral kinetics of sulbactam, a potent synergist with ampicillin against a broad range of clinically important organisms in humans, are similar to those of ... ampicillin were not affected by co-administration of sulbactam, and high levels of both agents were attained: ... 2 g of ampicillin plus 1 g of sulbactam produced peak serum concentrations of approximately 120 micrograms of ampicillin/ml plus 60 micrograms of sulbactam/ml; intramuscular injections of 1 g of ampicillin plus 0.5 g of sulbactam produced peak concentrations of 18 micrograms of ampicillin/ ...
Tópico(s): Pneumonia and Respiratory Infections
1986 - Oxford University Press | Clinical Infectious Diseases
R. F. Musbinsky, M. L. Reynolds, C. A. Nicbolson, L. L. Crider, G. A. Forcier,
Compatibility studies were conducted of sulbactam/ampicillin in infusion diluents that are reported to be compatible with ampicillin sodium. A high-performance liquid chromatographic system that simultaneously detects sulbactam and ampicillin was used to determine whether the ... use recommended for ampicillin sodium are applicable to sulbactam/ampicillin. The results show that the sulbactam/ampicillin preparation for parenteral administration is compatible with ... diluents recommended for ampicillin sodium. In all diluents sulbactam was more stable than ampicillin. At the end ...
Tópico(s): Pharmaceutical studies and practices
1986 - Oxford University Press | Clinical Infectious Diseases
Robert A. Blum, R. Kohli, Nedra J. Harrison, Jerome J. Schentag,
... of intravenously administered ampicillin (2.0 g) and sulbactam (1.0 g) were studied in normal subjects ... studied. The terminal half-lives for ampicillin and sulbactam more than doubled in patients with severe renal ... significantly correlated with ampicillin (r = 0.88) and sulbactam (r = 0.54) total body clearance. Mean steady- ... of distribution and nonrenal clearance for ampicillin and sulbactam were not affected by renal function. Hemodialysis approximately doubled the ampicillin and sulbactam total body clearance. Mean totals of 34.8 +/- ...
Tópico(s): Renal Transplantation Outcomes and Treatments
1989 - American Society for Microbiology | Antimicrobial Agents and Chemotherapy
N. A. KUCK, N V Jacobus, Peter J. Petersen, Jason Weiss, R. T. TESTA,
... lactamase inhibitor, was compared with clavulanic acid and sulbactam for enhancement of the activity of piperacillin against ... was generally more effective. Tazobactam was superior to sulbactam in enhancing the spectrum and potency of piperacillin. ... spp., and Shigella spp. Combinations with tazobactam and sulbactam, but not clavulanic acid, were effective against Morganella ... with clavulanic acid but not with tazobactam or sulbactam. The inhibitors were similarly effective with piperacillin against ... a broader spectrum of activity than combinations with sulbactam against bacteria that produce characterized plasmid-mediated enzymes ...
Tópico(s): Antibiotic Use and Resistance
1989 - American Society for Microbiology | Antimicrobial Agents and Chemotherapy
Sakurako Kobayashi, S Arai, Saeko Hayashi, Takuya Sakaguchi,
... of beta-lactams with two beta-lactamase inhibitors, sulbactam and clavulanic acid, were determined in vitro against ... aureus. Combinations of cefpirome, cefotaxime, and cefazolin with sulbactam (10 micrograms/ml) showed synergistic effects against more ... strains. Combinations of methicillin and penicillin G with sulbactam also showed synergistic effects against 50 and 68% ... cefotiam, moxalactam, flomoxef, and cefmetazole in combination with sulbactam showed such effects against only 40% or fewer. ... to the beta-lactamase inhibition by the inhibitor. Sulbactam did not improve the antimicrobial activities of the ...
Tópico(s): Antibiotic Resistance in Bacteria
1989 - American Society for Microbiology | Antimicrobial Agents and Chemotherapy
Jay P. Rho, Alan Wayne Jones, Margie Woo, Steven C. Castle, Karen Smith, Roger E. Bawdon, Dean C. Norman,
The pharmacokinetics of intravenous ampicillin and sulbactam, a β-lactamase inhibitor, were evaluated in two different age groups. Twelve healthy elderly subjects (age 65–93 years) and 12 healthy ... both a dose of ampicillin 1 g plus sulbactam 0·5 g and a higher dose of ampicillin 2 g plus sulbactam 1 g after a one-week period between ... was used for the quantitation of ampicillin and sulbactam in serum and urine. The pharmacokinetic parameters for both ampicillin and sulbactam were calculated by computer-based two-compartment nonlinear ...
Tópico(s): Pharmaceutical studies and practices
1989 - Oxford University Press | Journal of Antimicrobial Chemotherapy
John M. Benson, Milap C. Nahata,
Sulbactam/ampicillin is a combination of a beta-lactamase inhibitor with minimal intrinsic antibacterial activity (sulbactam sodium), and an aminopenicillin (ampicillin sodium). The addition of sulbactam to ampicillin has no effect on the chemical ... combination are the same as for ampicillin alone. Sulbactam acts primarily by irreversible inactivation of beta-lactamases ... most beta-lactamase-producing organisms. The pharmacokinetics of sulbactam are similar to those of ampicillin with an ... difference is that serum and tissue concentrations of sulbactam are usually twice those of ampicillin, at equivalent ...
Tópico(s): Antibiotic Use and Resistance
1988 - SAGE Publishing | Drug Intelligence & Clinical Pharmacy
A Wildfeuer, Valter Muller, M. Springsklee, H.‐G. Sonntag,
The pharmacokinetics of ampicillin and sulbactam, a new beta-lactamase inhibitor, were investigated in 16 patients undergoing prosthetic cardiac valve insertion. The combination of 2 g of ampicillin and 1 g of sulbactam was administered as perioperative prophylaxis intravenously over 3 ... The half-lives of elimination of ampicillin and sulbactam were 79 +/- 4.9 and 88 +/- 5.9 ... min, respectively. The peak concentrations of ampicillin and sulbactam in serum were calculated to be 134.3 +/- ... 3 +/- 1.2 micrograms/ml, respectively. Ampicillin and sulbactam rapidly penetrated from the blood into various tissues ...
Tópico(s): Pneumocystis jirovecii pneumonia detection and treatment
1991 - American Society for Microbiology | Antimicrobial Agents and Chemotherapy
Burt R. Meyers, P. J. Wilkinson, Meryl H. Mendelson, Sarah K. Walsh, Cynthia Bournazos, Shalom Z. Hirschman,
The pharmacokinetics of ampicillin-sulbactam in elderly subjects (65 to 85 years; group 3, n = 8), compared with those in middle-aged (41 to 64 ... dose of ampicillin combined with 1 g of sulbactam in 60 ml of intravenous solution was administered ... 5-h period following the infusion. Ampicillin and sulbactam concentrations were assayed by high-performance liquid chromatography ... mean levels in serum of both ampicillin and sulbactam were significantly higher for samples from group 3: ... from 1 through 8.5 h, and for sulbactam for the same time interval except at 5. ...
Tópico(s): Antibiotic Resistance in Bacteria
1991 - American Society for Microbiology | Antimicrobial Agents and Chemotherapy
Uwe Frank, Justin Mutter, E. Schmidt-Eisenlohr, Franz Daschner,
... the antimicrobial activity of piperacillin-tazobactam versus piperacillin–sulbactam against common nosocomial pathogens (n = 565) isolated from ... against Escherichia coli and Proteus vulgaris than piperacillin–sulbactam. Both combinations, however, were equally effective against the other Enterobacteriaceae and Pseudomonas aeruginosa isolates. Piperacillin–sulbactam exhibited better antimicrobial activity against Acinetobacter baumannii. Our ... the antimicrobial activity of piperacillin-tazobactam versus piperacillin–sulbactam against common nosocomial pathogens (n = 565) isolated from ...
Tópico(s): Nosocomial Infections in ICU
2003 - Elsevier BV | Clinical Microbiology and Infection
Antonios N. Maniatis, Spyros Pournaras, S. Orkopoulou, Panayotis T. Tassios, N.J. Legakis,
... majority of the isolates exhibited resistance to ampicillin–sulbactam, and the most common antibiotic resistance profiles comprised ... majority of the isolates exhibited resistance to ampicillin–sulbactam, and the most common antibiotic resistance profiles comprised ... LS Tsakris A In-vitro activity of ampicillin/sulbactam against multiresistant Acinetobacter calcoaceticus var. anitratus clinical isolates. ... Scholar]. The antimicrobial agents tested were amikacin, ampicillin–sulbactam, aztreonam, ceftazidime, ciprofloxacin, gentamicin, imipenem, netilmicin, piperacillin, ticarcillin– ...
Tópico(s): Vibrio bacteria research studies
2003 - Elsevier BV | Clinical Microbiology and Infection
James McGregor, William R. Crombleholme, Edward R. Newton, Richard L. Sweet, Ruth Tuomala, Ronald S. Gibbs,
To evaluate the efficacy and safety of ampicillin-sulbactam (3 g every 6 hours) in patients with ... inflammatory disease were randomized to receive either ampicillin-sulbactam or cefoxitin (2 g every 6 hours) plus ... hours). Those with endometritis were randomized to ampicillin-sulbactam or clindamycin (900 mg every 8 hours) plus ... mg/kg every 8 hours). In the ampicillin-sulbactam group, chlamydia-positive patients also received oral doxycycline. ... 89.6% (43 of 48) in the ampicillin-sulbactam and cefoxitin and doxycycline groups, respectively (chi 2 = ...
Tópico(s): Reproductive System and Pregnancy
1994 - Lippincott Williams & Wilkins | Obstetrics and Gynecology
... either ceftriaxone, fluoroquinolone (levofloxacin, moxifloxacin, or ciprofloxacin), ampicillin-sulbactam, or ertapenem. The second group, with late-onset ... lactamase inhibitor combinations (amoxicillin/clavulanic acid or ampicillin/sulbactam), and ertapenem are recommended when monotherapy is indicated. ... lactam/β-lactamase inhibitor (amoxicillin/clavulanic acid; ampicillin/sulbactam)orcarbepenems (ertapenem)orthird-generation cephalosporins plus macrolideormonobactam plus ... may be considered by Asian clinicians include cefoperazone/sulbactam plus fluoroquinolones or aminoglycosides or ampicillin/sulbactam or ...
Tópico(s): Antibiotic Resistance in Bacteria
2008 - Elsevier BV | American Journal of Infection Control
María Eugenia Pachón-Ibáñez, Fernando Docobo-Pérez, Rafael López-Rojas, Juan Domínguez-Herrera, Jiménez-Mejías Me, A. García-Curiel, C. Pichardo, Luís Jiménez, Jerónimo Pachón,
... infections. We evaluated the efficacy of rifampin, imipenem, sulbactam, colistin, and their combinations against MDR A. baumannii ... The bactericidal in vitro activities of rifampin, imipenem, sulbactam, colistin, and their combinations were tested using time- ... baummnnii strain Ab1327 (with MICs for rifampin, imipenem, sulbactam, and colistin of 4, 32, 32, and 0. ... of colistin, rifampin and its combinations with imipenem, sulbactam, or colistin, and of imipenem plus sulbactam were assayed. In the pneumonia model, compared to ...
Tópico(s): Drug Transport and Resistance Mechanisms
2010 - American Society for Microbiology | Antimicrobial Agents and Chemotherapy
Rebecca Waltner-Toews, David L. Paterson, Zubair Qureshi, Hanna E. Sidjabat, Jennifer Adams‐Haduch, Kathleen A. Shutt, Mark Jones, Guo‐Bao Tian, A. William Pasculle, Yohei Doi,
Ampicillin-sulbactam is commonly used as an empirical therapy for invasive infections where Escherichia coli is a potential pathogen. ... focus on cases that were nonsusceptible to ampicillin-sulbactam and not producing extended-spectrum β-lactamase (ESBL). ... 31.1%) were intermediate or resistant to ampicillin-sulbactam by disk testing. In multivariate analysis, a history ... peptic ulcer disease, and prior use of ampicillin-sulbactam were independent risk factors for bloodstream infection with ampicillin-sulbactam-nonsusceptible E. coli. Among cases that received ampicillin- ...
Tópico(s): Escherichia coli research studies
2010 - American Society for Microbiology | Antimicrobial Agents and Chemotherapy
Wesley McMillian, Josef Bednařík, Joseph J. Aloi, John W. Ahern, Bruce Crookes,
Ampicillin-sulbactam is guideline-recommended treatment for early-onset ventilator-associated pneumonia (VAP). However, intensive care unit clinicians are encountering increasing resistance to ampicillin-sulbactam. We sought to analyze the time period for ... by using daily evaluation of resistance to ampicillin-sulbactam.A retrospective cohort study was completed on all ... diagnosed with VAP. Daily bacterial resistance to ampicillin-sulbactam > 15% was defined as the threshold for early ... completed to assess for predisposing factors for ampicillin-sulbactam resistance.One hundred sixty-three pathogens were identified ...
Tópico(s): Antibiotic Resistance in Bacteria
2010 - Lippincott Williams & Wilkins | Journal of Trauma and Acute Care Surgery
Julia Langgartner, Norbert Lehn, T. Glück, H. Herzig, Frieder Kees,
<i>Background:</i> The antibacterial effect of piperacillin/sulbactam depends on the time of drug concentration above ... Seven intensive care unit patients received either piperacillin/sulbactam as 4/1 g intravenous infusion over 15– ... i> Pharmacokinetic parameters (mean ± SD) for SI piperacillin/sulbactam were: (1) peak serum concentration: piperacillin 231 ± 66 mg/l, sulbactam 53.1 ± 15.0 mg/l; (2) minimum ... concentration: piperacillin 11.5 ± 14.8 mg/l, sulbactam 4.2 ± 3.5 mg/l; (3) clearance: ... 72 ml/min (CI 269 ± 123 ml/min), sulbactam 167 ± 61 ml/min (CI 212 ± 109 ml/ ...
Tópico(s): Antibiotic Resistance in Bacteria
2007 - Karger Publishers | Chemotherapy
Monica A. Totir, Marion S. Helfand, Marianne P. Carey, Anjaneyulu Sheri, John D. Buynak, Robert A. Bonomo, Paul Carey,
Sulbactam is a mechanism-based inhibitor of β-lactamase enzymes used in clinical practice. It undergoes a ... a branch point on the reaction pathway. Using sulbactam and 6,6-dideuterated sulbactam we follow these alternate paths in WT and ... studies on single enzyme crystals. For the unlabeled sulbactam, the Raman data show the presence of an ... intermediate. It is proposed that for the unsubstituted sulbactam the conversion from imine to enamine, which involves ... quantum mechanical tunneling. For the 6,6-dideutero-sulbactam the same step involves breaking a C−D ...
Tópico(s): Antibiotics Pharmacokinetics and Efficacy
2007 - American Chemical Society | Biochemistry
Min-Nan Hung, Po‐Ren Hsueh, Hou-Tai Chang, Wen‐Sen Lee, Ming-Yuan Chou, Ing-Shen Chen, Jen-Hsien Wang, Chen-Fu Lin, Jainn-Ming Shyr, Wen‐Chien Ko, Jiunn-Jong Wu, Yung-Ching Liu, Wen-Kuei Huang, Lee‐Jene Teng, Cheng‐Yi Liu, Kwen‐Tay Luh,
... the in vitro activity of various piperacillin and sulbactam combinations against Gram-negative bacterial isolates from Intensive ... hospitals was performed using the agar dilution method. Sulbactam was added to piperacillin either at a fixed sulbactam concentration of 4 mg/L and 8 mg/L or at a piperacillin:sulbactam ratio of 2:1 and 4:1. Piperacillin/sulbactam at a ratio of 2:1 or a fixed 8 mg/L concentration of sulbactam had better activities against Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis and Serratia marcescens than other piperacillin/sulbactam formulations. For Pseudomonas aeruginosa, piperacillin/sulbactam (2:1 ...
Tópico(s): Antibiotic Use and Resistance
2006 - Elsevier BV | International Journal of Antimicrobial Agents
Bruce A. Mueller, Bridget A. Scoville,
... Lorenzen et al. (7) addresses dosing of ampicillin/sulbactam in a pharmacokinetic study in this patient population. ... projected pharmacodynamic effects. These investigators measured ampicillin and sulbactam plasma concentrations achieved in critically ill patients receiving ... ED is instituted 3 hours after the ampicillin/sulbactam 2/1-g infusion ended. The ED session removed >80% of the ampicillin/sulbactam dose. With these drug administration parameters and ED ... mentions, the problem is that the same ampicillin/sulbactam 2/1-g dose administered at a time ...
Tópico(s): Antibiotic Resistance in Bacteria
2012 - Lippincott Williams & Wilkins | Clinical Journal of the American Society of Nephrology
Johan M. Lorenzen, Michael Broll, Volkhard Kaever, Heike Burhenne, Carsten Hafer, Christian Clajus, Wolfgang Knitsch, Olaf Burkhardt, Jan T. Kielstein,
... objectives The fixed antibacterial combination of ampicillin and sulbactam is frequently used for various infections. Intact kidneys eliminate approximately 71% of ampicillin and 78% of sulbactam. Patients on thrice-weekly low-flux hemodialysis exhibit ... study were to evaluate the pharmacokinetics of ampicillin/sulbactam in critically ill patients with AKI undergoing extended ... study. Pharmacokinetics after a single dose of ampicillin/sulbactam (2 g/1 g) was obtained in 12 ... pharmacokinetics after 4 days of twice-daily ampicillin/sulbactam (2 g/1 g) was obtained in three ...
Tópico(s): Poisoning and overdose treatments
2012 - Lippincott Williams & Wilkins | Clinical Journal of the American Society of Nephrology
Julio A. Ramírez, James T. Summersgill, Richard D. Miller, Tracy L. Meyers, Martin J. Raff,
Intracellular bactericidal activity of ampicillin/sulbactam and erythromycin was determined with a human macrophage-like (U-937) cell line infected with Legionella pneumophila. Cell monolayers inoculated with L. pneumophila were treated with erythromycin, ampicillin, sulbactam, or ampicillin/sulbactam during the logarithmic phase of bacterial growth. Intracellular ... significantly in the cultures treated with ampicillin or sulbactam, decreased by 0·8 × log10 cfu/mL (P < ... by 1·8 × log10 cfu/mL with ampicillin/sulbactam (P < 0·05). The number of cfu/mL ...
Tópico(s): Antibiotics Pharmacokinetics and Efficacy
1993 - Oxford University Press | Journal of Antimicrobial Chemotherapy
Allan Chamberlain, Sandra White, Roger E. Bawdon, Stuart Thomas, Bryan Larsen,
... pregnancy had on pharmacokinetic parameters of ampicillin and sulbactam. STUDY DESIGN: Twenty-two women undergoing cesarean section ... gm of ampicillin plus 0.5 gm of sulbactam intravenously after umbilical cord clamping. Blood was drawn ... antibiotic for determination of serum ampicillin and/or sulbactam levels. Pharmacokinetic parameters were determined by fitting data ( ... these parameters in the nonpregnant state for ampicillin. Sulbactam kinetics were similarly affected, although these changes failed ...
Tópico(s): Antibiotic Use and Resistance
1993 - Elsevier BV | American Journal of Obstetrics and Gynecology
Les N. Heddleston, Robert S. McDuffie, Ronald S. Gibbs,
... 70% of gestation and assigned animals to ampicillin-sulbactam therapy beginning at 0, 4, 8, 12, and ... receiving no antibiotic therapy and rabbits starting ampicillin-sulbactam 4 hours after inoculation. Results: Compared with saline ... but did not significantly improve fetal survival. Ampicillin-sulbactam treatment stated at 0, 4, 8, and 12 ... did not result in improved fetal survival. Ampicillin-sulbactam therapy, initiated as long as 12 hours after ... 70% of gestation and assigned animals to ampicillin-sulbactam therapy beginning at 0, 4, 8, 12, and ...
Tópico(s): Reproductive Physiology in Livestock
1993 - Elsevier BV | American Journal of Obstetrics and Gynecology
Chun-Ming Lee, Hwee-Kheng Lim, Chang-Pan Liu, Hsiang-Kuang Tseng,
... this study was to investigate the role of sulbactam in the treatment of pan-drug resistant Acinetobacter ... A (n = 39) were treated with carbapenem with sulbactam and group B (n = 30) with second and ... strains by using antimicrobial agents with and without sulbactam. The clinical outcomes of the 2 groups did ... of the 48 strains were sensitive to imipenem/sulbactam, compared with only 2 of the 48 to imipenem alone. The addition of sulbactam thus reversed the response in 30% (14/46) ... intermediate sensitive to imipenem. The MICs for meropenem/sulbactam were in the sensitive range for 8 of ...
Tópico(s): Pneumonia and Respiratory Infections
2005 - Informa | Scandinavian Journal of Infectious Diseases
Nicola Petrosillo, M.F. Proietti, Luca Cecchini, M.V. Masala, C. Franchi, Mario Venditti, Silvano Esposito, Emanuele Nicastri, Pierangelo Chinello,
... antimicrobial agent in combination with polymixin B, ampicillin–sulbactam and colistin [2Tascini C Menichetti F Bozza S ... drug combinations of rifampicin, polymixin B and ampicillin/sulbactam against Acinetobacter baumannii..J Antimicrob Chemother. 1998; 42: ... 24 days). Five of ten patients with ampicillin–sulbactam-susceptible carbapenem-resistant A. baumannii also received intravenous ampicillin–sulbactam. Deterioration in renal function (creatininaemia of up to ... Thus, therapy with colistin–rifampicin, and with ampicillin–sulbactam in case of susceptibility to this combination, resulted ...
Tópico(s): Pneumonia and Respiratory Infections
2005 - Elsevier BV | Clinical Microbiology and Infection
Pius S. Padayatti, Marion S. Helfand, Monica A. Totir, Marianne P. Carey, Paul Carey, Robert A. Bonomo, Focco van den Akker,
... resolution crystal structures of the β-lactamase inhibitors sulbactam and clavulanic acid bound to the deacylation-deficient ... near 1595 cm-1. Band broadening in the sulbactam and clavulanic acid inter-mediates reflected a heterogeneous ... resolution crystal structures of the β-lactamase inhibitors sulbactam and clavulanic acid bound to the deacylation-deficient ... near 1595 cm-1. Band broadening in the sulbactam and clavulanic acid inter-mediates reflected a heterogeneous ... lactamase inhibitors are available for clinical use: tazobactam, sulbactam, and clavulanic acid (Fig. 1A) (4Lee N. Yuen ...
Tópico(s): Phenothiazines and Benzothiazines Synthesis and Activities
2005 - Elsevier BV | Journal of Biological Chemistry