Sumitra Dash, Sudarshan Kumar, Radharaman Jiban Dash,
... EditorFree Access Hematological malignancy in hemoglobin D disease Sumitra Dash, Sumitra Dash Department of Haematology and Endocrinology Postgraduate Institute ... Chandigarh, IndiaSearch for more papers by this author Sumitra Dash, Sumitra Dash Department of Haematology and Endocrinology Postgraduate Institute ...
Tópico(s): Chronic Lymphocytic Leukemia Research
1988 - Wiley | American Journal of Hematology
Sumitra Sivakoti, Patrick Yesudian,
... 676 Painful Tufted Angioma Precipitated by Trauma S. Sumitra, S. Sumitra M.D. Madras, IndiaSearch for more papers by ... IndiaSearch for more papers by this author S. Sumitra, S. Sumitra M.D. Madras, IndiaSearch for more papers by ...
Tópico(s): Histiocytic Disorders and Treatments
1994 - Wiley | International Journal of Dermatology
B. T. F. Chung, P. S. Sumitra,
... on: This Site PubMed Google Scholar P. S. Sumitra P. S. Sumitra Mechanical Engineering Department, University of Akron, Akron, Ohio ... Department, University of Akron, Akron, Ohio P. S. Sumitra Mechanical Engineering Department, University of Akron, Akron, Ohio ...
Tópico(s): Gas Dynamics and Kinetic Theory
1972 - ASM International | Journal of Heat Transfer
Subbarao V. Yalla, Sumitra S. Yalla, James W. Morgan, C Eberhart, James F. Olley,
... and Survey of the Literature Subbarao V. Yalla, Sumitra S. Yalla, James W. Morgan, Charles A. Eberhart, ... Philadelphia, Pennsylvania 19146. More articles by this author , Sumitra S. YallaSumitra S. Yalla Current address: Department of ... Philadelphia, Pennsylvania 19146. More articles by this author Sumitra S. Yalla Current address: Department of Pathology, Temple ...
Tópico(s): Neuroendocrine Tumor Research Advances
1974 - Lippincott Williams & Wilkins | The Journal of Urology
Sumitra Tatapudy, Francesca M. Aloisio, Diane L. Barber, Todd Nystul,
... emerging roles for metabolic signals and cell morphology Sumitra Tatapudy Departments of Anatomy and OB-GYN/RS, ... USA Search for more papers by this author Sumitra Tatapudy Departments of Anatomy and OB-GYN/RS, ... for more papers by this author Author Information Sumitra Tatapudy1, Francesca Aloisio2, Diane Barber2 and Todd Nystul *, ...
Tópico(s): Mitochondrial Function and Pathology
2017 - Springer Nature | EMBO Reports
David Simpson, E. T. W. Bowen, G.S. Platt, Hilary Way, Chris Smith, S. Peto, Sumitra Kamath, Boo Liat Lim, Teong Wah Lim,
... this author on: Oxford Academic PubMed Google Scholar Sumitra Kamath, Sumitra Kamath Institute for Medical Research, Kuala Lumpur, Malaysia ...
Tópico(s): HIV Research and Treatment
1970 - Oxford University Press | Transactions of the Royal Society of Tropical Medicine and Hygiene
Arti Nanda, Rajeev Sharma, Amrinder J. Kanwar, Surrinder Kaur, Sumitra Dash,
... more papers by this authorSumitra Dash M.D., Sumitra Dash M.D. From the Departments of Dermatology ... more papers by this authorSumitra Dash M.D., Sumitra Dash M.D. From the Departments of Dermatology ...
Tópico(s): Toxin Mechanisms and Immunotoxins
1990 - Wiley | International Journal of Dermatology
Mital J. Kaneria, Sumitra Chanda,
... more papers by this authorSUMITRA CHANDA, Corresponding Author SUMITRA CHANDA Phytochemical, Pharmacological and Microbiological Laboratory, Department of ... more papers by this authorSUMITRA CHANDA, Corresponding Author SUMITRA CHANDA Phytochemical, Pharmacological and Microbiological Laboratory, Department of ...
Tópico(s): Ethnobotanical and Medicinal Plants Studies
2011 - Wiley | Journal of Food Biochemistry
Catherine A. Vaughan, Isabella Pearsall, Shilpa Singh, Brad E. Windle, Swati Palit Deb, Steven R. Grossman, W. Andrew Yeudall, Sumitra Deb,
... W. Andrew Yeudall 1,2,4,6 and Sumitra Deb 1,2,3 1 Department of Biochemistry ... Biology, Augusta University, Augusta, GA, USA Correspondence to: Sumitra Deb, email: // Keywords : addiction, mutant, p53, transcription, EGFR ...
Tópico(s): Cancer-related gene regulation
2016 - Impact Journals LLC | Oncotarget
Kelly Harrington, Xuan‐Mai T. Nguyen, Rebecca J. Song, Keri Hannagan, Rachel Quaden, David R. Gagnon, Kelly Cho, Jennifer E. Deen, Sumitra Muralidhar, Timothy J. O’Leary, John Michael Gaziano, Stacey B. Whitbourne, J. Michael Gaziano, Rachel Ramoni, Jim Breeling, Kyong–Mi Chang, Grant D. Huang, Sumitra Muralidhar, Christopher J. O’Donnell, Philip S. Tsao, Sumitra Muralidhar, Jennifer Moser, Stacey B. Whitbourne, Jessica V. Brewer, John Concato, Stuart Warren, D Pharm, Dean P. Argyres, Philip S. Tsao, J. Michael Gaziano, Brady Stephens, Mary T. Brophy, Donald E. Humphries, Nhan Do, Shahpoor Shayan, Xuan‐Mai T. Nguyen, Christopher J. O’Donnell, Saiju Pyarajan, Philip S. Tsao, Kelly Cho, Saiju Pyarajan, Elizabeth R. Hauser, Yan Sun, Hongyu Zhao, Peter W.F. Wilson, Rachel McArdle, Louis J. Dell’Italia, John B. Harley, Jeff Whittle, Jean C. Beckham, John M. Wells, Salvador Gutierrez, Gretchen Gibson, Laurence S. Kaminsky, Gerardo Villareal, Scott Kinlay, Junzhe Xu, Mark B. Hamner, Kathlyn Sue Haddock, Sujata Bhushan, Pran Iruvanti, Michael Godschalk, Zuhair K. Ballas, Malcolm Buford, Stephen Mastorides, Jon Klein, Nora Ratcliffe, Hermes Flórez, Alan C. Swann, Maureen Murdoch, Peruvemba Sriram, Shing Shing Yeh, Ronald G. Washburn, Darshana Jhala, Samuel M. Aguayo, David Cohen, Satish Sharma, John T. Callaghan, Kris Ann Oursler, Mary A. Whooley, Sunil K. Ahuja, Amparo Gutierrez, Ronald Schifman, Jennifer Greco, Michael Rauchman, Richard J. Servatius, Mary E. Oehlert, Agnes Wallbom, Ronald Fernando, Timothy R. Morgan, Todd Stapley, Scott E. Sherman, Gwenevere Anderson, Philip S. Tsao, Elif Sonel, Edward J. Boyko, Laurence Meyer, Samir Gupta, Joseph Fayad, Adriana M. Hung, Jack Lichy, Robin A. Hurley, R. Brooks Robey, Rob Striker,
BackgroundThe Department of Veterans Affairs Million Veteran Program (MVP) is the largest ongoing cohort program of its kind, with 654,903 enrollees as of June 2018. The objectives of this study were to examine gender differences in the MVP cohort with respect to response and enrollment rates; demographic, health, and health care characteristics; and prevalence of self-reported health conditions.MethodsThe MVP Baseline Survey was completed by 415,694 veterans (8% women), providing self-report measures ...
Tópico(s): Occupational Health and Performance
2019 - Elsevier BV | Women s Health Issues
Xuan‐Mai T. Nguyen, Stacey B. Whitbourne, Yanping Li, Rachel Quaden, Rebecca J. Song, Hai-Nam A Nguyen, Kelly Harrington, Luc Djoussé, Jessica V. Brewer, Jennifer E. Deen, Sumitra Muralidhar, Rachel Ramoni, Kelly Cho, Juan P. Casas, Philip S. Tsao, John Michael Gaziano, Sumitra Muralidhar, Jennifer Moser, Jennifer E. Deen, J. Michael Gaziano, Sumitra Muralidhar, Jean C. Beckham, Kyong–Mi Chang, Philip S. Tsao, Shiuh‐Wen Luoh, Juan P. Casas, J. Michael Gaziano, Philip S. Tsao, Juan P. Casas, Lori Churby, Stacey B. Whitbourne, Jessica V. Brewer, Mary T. Brophy, Luis E. Selva, Shahpoor Shayan, Kelly Cho, Saiju Pyarajan, Philip S. Tsao, Kelly Cho, Scott L. DuVall, Todd Connor, Dean P. Argyres, Philip S. Tsao, J. Michael Gaziano, Brady Stephens, Peter D. Wilson, Rachel McArdle, Louis J. Dell’Italia, Kristin Mattocks, John B. Harley, Jeff Whittle, Frank J. Jacono, Jean C. Beckham, John M. Wells, Salvador Gutierrez, Kathrina Alexander, Kimberly Hammer, James Norton, Gerardo Villareal, Scott Kinlay, Junzhe Xu, Mark B. Hamner, Roy O. Mathew, Sujata Bhushan, Pran Iruvanti, Michael Godschalk, Zuhair K. Ballas, River Smith, Stephen Mastorides, Jonathan P. Moorman, Saib Gappy, Jon Klein, Nora Ratcliffe, Ana Palacio, Olaoluwa Okusaga, Maureen Murdoch, Peruvemba Sriram, Shing Shing Yeh, Neeraj Tandon, Darshana Jhala, Samuel M. Aguayo, David Cohen, Satish Sharma, Suthat Liangpunsakul, Kris Ann Oursler, Mary A. Whooley, Sunil K. Ahuja, Joseph Constans, Paul Meyer, Jennifer Greco, Michael Rauchman, Richard J. Servatius, Melinda Gaddy, Agnes Wallbom, Timothy R. Morgan, Todd Stapley, Peter S. Liang, Daryl Fujii, Philip S. Tsao, Patrick Strollo, Edward J. Boyko, Jessica Walsh, Samir Gupta, Mostaqul Huq, Joseph Fayad, Adriana M. Hung, Jack Lichy, Robin A. Hurley, R. Brooks Robey, Prakash Balasubramanian,
Tópico(s): Health Policy Implementation Science
2022 - Oxford University Press | International Journal of Epidemiology
Catherine A. Vaughan, Swati Palit Deb, Sumitra Deb, Brad E. Windle,
... Vaughan 1 , Swati P. Deb 1,3,4 , Sumitra Deb 1,3,4 and Brad Windle 1, ... Commonwealth University, Richmond, VA Correspondence: Brad Windle, email: // Sumitra Deb, email: // Keywords : mutant p53, ChIP-Seq, ETS1, ...
Tópico(s): Epigenetics and DNA Methylation
2014 - Impact Journals LLC | Oncotarget
Sumitra Dash, Titus H.J. Huisman,
... FROM PUNJAB (NORTH INDIA): To the Editor: Dr. Sumitra Dash, Corresponding Author Dr. Sumitra Dash Head Department of Haematology Postgraduate Institute of ... Search for more papers by this author Dr. Sumitra Dash, Corresponding Author Dr. Sumitra Dash Head Department of Haematology Postgraduate Institute of ...
Tópico(s): Neurological and metabolic disorders
1988 - Wiley | European Journal Of Haematology
... IndiaSearch for more papers by this authorSumitra Dash, Sumitra Dash Department of Hematology, Postgraduate Institute of Medical ... IndiaSearch for more papers by this authorSumitra Dash, Sumitra Dash Department of Hematology, Postgraduate Institute of Medical ...
Tópico(s): Immune Cell Function and Interaction
2004 - Wiley | American Journal of Hematology
Narindar Nath, Sumitra Nag, J.C. Seidel,
... fragments of the gizzard myosin heavy chainNarindar Nath, Sumitra Nag, and John C. SeidelCite this: Biochemistry 1986, ...
Tópico(s): Cardiomyopathy and Myosin Studies
1986 - American Chemical Society | Biochemistry
The UL9 gene of herpes simplex virus (HSV) codes for a DNA-binding protein (OBP) that interacts sequence specifically with the origin of replication. This protein is essential for HSV DNA replication in cultured cells. The UL9 gene was cloned into a plasmid vector downstream of the SP6 RNA polymerase promoter. By using in vitro transcription and translation systems, a full-length OBP was synthesized. This synthetic protein is recognized by an antiserum generated against the C-terminal decapeptide ...
Tópico(s): Virus-based gene therapy research
1991 - American Society for Microbiology | Journal of Virology
Daniel W. Martin, Sumitra Deb, J S Klauer, Sumitra Deb,
The herpes simplex virus type 1 (HSV-1) OriS region resides within a 90-bp sequence that contains two binding sites for the origin-binding protein (OBP), designated sites I and II. A third presumptive OBP-binding site (III) within OriS has strong sequence similarity to sites I and II, but no sequence-specific OBP binding has yet been demonstrated at this site. We have generated mutations in sites I, II, and III and determined their replication efficiencies in a transient in vivo assay in the presence ...
Tópico(s): Poxvirus research and outbreaks
1991 - American Society for Microbiology | Journal of Virology
Mariano J. Scian, Evie H. Carchman, Lathika Mohanraj, Katherine E. Stagliano, Michelle A. E. Anderson, Dhruba Deb, Ben Crane, Tohru Kiyono, B E Windle, Sumitra Deb, Sumitra Deb,
Tópico(s): Epigenetics and DNA Methylation
2007 - Springer Nature | Oncogene
Samir Kumar‐Singh, Mahesh Ramamoorthy, Catherine A. Vaughan, W. Andrew Yeudall, Sumitra Deb, Sumitra Deb,
The current paradigm states that the Akt signaling pathway phosphorylates the human oncoprotein mouse double minute 2 (MDM2), leading to its nuclear translocation and degradation of the tumor suppressor p53. Here we report a novel Akt signaling pathway elicited by MDM2. Upregulation of endogenous MDM2 promotes, whereas its downregulation diminishes, Akt phosphorylation irrespective of p53 status. MDM2 requires phosphatidylinositol (PI)3-kinase activity for enhancing Akt phosphorylation and upregulates ...
Tópico(s): Ubiquitin and proteasome pathways
2012 - Springer Nature | Cell Death and Differentiation
Catherine A. Vaughan, Sandeep K. Singh, B E Windle, W. Andrew Yeudall, Rebecca A. Frum, S. R. Grossman, Sumitra Deb, Sumitra Deb,
p53 mutations are present in up to 70% of lung cancer. Cancer cells with p53 mutations, in general, grow more aggressively than those with wild-type p53 or no p53. Expression of tumor-derived mutant p53 in cells leads to up-regulated expression of genes that may affect cell growth and oncogenesis. In our study of this aggressive phenotype, we have investigated the receptor protein tyrosine kinase Axl, which is up-regulated by p53 mutants at both RNA and protein levels in H1299 lung cancer cells ...
Tópico(s): Pancreatic and Hepatic Oncology Research
2012 - SAGE Publishing | Genes & Cancer
Doris Brown, Sumitra Deb, Raquel Muñoz, Mark A. Subler, Sumitra Deb,
The oncogene mdm2 has been found to be amplified in human sarcomas, and the gene product binds to the tumor suppressor p53. In this report, we describe the dissection of the MDM2-binding domain on p53 as well as the p53-binding domain on MDM2. We also demonstrate that the oncoprotein simian virus 40 T antigen binds to the product of cellular oncogene mdm2. We have constructed several N- and C-terminal deletion mutants of p53 and MDM2, expressed them in vitro, and assayed their in vitro association ...
Tópico(s): Virus-based gene therapy research
1993 - Taylor & Francis | Molecular and Cellular Biology
Rebecca A. Frum, Sandeep K. Singh, Catherine A. Vaughan, Nitai D. Mukhopadhyay, S. R. Grossman, B E Windle, Sumitra Deb, Sumitra Deb,
Conventional paradigm ascribes the cell proliferative function of the human oncoprotein mouse double minute2 (MDM2) primarily to its ability to degrade p53. Here we report that in the absence of p53, MDM2 induces replication stress eliciting an early S-phase checkpoint response to inhibit further firing of DNA replication origins. Partially synchronized lung cells cultured from p53−/−:MDM2 transgenic mice enter S phase and induce S-phase checkpoint response earlier than lung cells from p53−/− mice ...
Tópico(s): Carcinogens and Genotoxicity Assessment
2013 - Oxford University Press | Nucleic Acids Research
Bryan E. Strauss, C. V. Shivakumar, Sumitra Deb, Sumitra Deb, MJ Haas,
We have examined the interaction of the wild-type p53 protein with the downstream promoter of the human multidrug resistance gene-1 (MDR1). Our findings indicate that wild type p53 inhibits reporter activity driven by the MDR1 downstream promoter (base pairs −189 to +133 relative to the major transcriptional initiation site) in a dose-dependent manner in cotransfection assays in the BHK and the Saos-2 cell lines. A 123 base-pair segment of DNA (−119 to +4 relative to the major transcriptional initiation ...
Tópico(s): Cancer-related Molecular Pathways
1995 - Elsevier BV | Biochemical and Biophysical Research Communications
Slim Kallel, Mohamed Jmaïel, Subrayal M. Reddy,
... by this author on: Oxford Academic Google Scholar Sumitra Reddy Sumitra Reddy 3Lane Department of Computer Science and Electrical ...
Tópico(s): Blockchain Technology Applications and Security
2015 - Oxford University Press | The Computer Journal
Annapoorna Sreedhar, Petra Petruska, Sumitra Miriyala, Manikandan Panchatcharam, Yunfeng Zhao,
// Annapoorna Sreedhar 1 , Petra Petruska 1 , Sumitra Miriyala 2 , Manikandan Panchatcharam 2 and Yunfeng Zhao 1 1 Department of Pharmacology, Toxicology & Neuroscience, LSU Health Sciences Center in Shreveport, Shreveport, ...
Tópico(s): Mitochondrial Function and Pathology
2017 - Impact Journals LLC | Oncotarget
Yan V. Sun, Scott M. Damrauer, Qin Hui, Themistocles L. Assimes, Yuk‐Lam Ho, Pradeep Natarajan, Derek Klarin, Jie Huang, Julie A. Lynch, Scott L. DuVall, Saiju Pyarajan, Jacqueline Honerlaw, J. Michael Gaziano, Kelly Cho, Daniel J. Rader, Christopher J. O’Donnell, Philip S. Tsao, Peter W.F. Wilson, Rachel Ramoni, Jim Breeling, Kyong–Mi Chang, Grant D. Huang, Sumitra Muralidhar, Sumitra Muralidhar, Jennifer Moser, Stacey B. Whitbourne, Jessica V. Brewer, John Concato, Stuart Warren, Dean P. Argyres, Brady Stephens, Mary T. Brophy, Donald E. Humphries, Nhan Do, Shahpoor Shayan, Xuan‐Mai T. Nguyen, Elizabeth R. Hauser, Yan V. Sun, Hongyu Zhao, Peter Wilson, Rachel McArdle, Louis J. Dell’Italia, John B. Harley, Jeff Whittle, Jean C. Beckham, John M. Wells, Salvador Gutierrez, Gretchen Gibson, Laurence S. Kaminsky, Gerardo Villareal, Scott Kinlay, Junzhe Xu, Mark B. Hamner, Kathlyn Sue Haddock, Sujata Bhushan, Pran Iruvanti, Michael Godschalk, Zuhair K. Ballas, Malcolm Buford, Stephen Mastorides, Jon B. Klein, Nora Ratcliffe, Hermes Flórez, Alan C. Swann, Maureen Murdoch, Peruvemba Sriram, Shing Shing Yeh, Ronald G. Washburn, Darshana Jhala, Samuel M. Aguayo, David Cohen, Satish Sharma, John T. Callaghan, Kris Ann Oursler, Mary A. Whooley, Sunil K. Ahuja, Amparo Gutierrez, Ronald Schifman, Jennifer Greco, Michael Rauchman, Richard J. Servatius, Mary E. Oehlert, Agnes Wallbom, Ronald Fernando, Timothy R. Morgan, Todd Stapley, Scott E. Sherman, Gwenevere Anderson, Philip S. Tsao, Elif Sonel, Edward J. Boyko, Laurence Meyer, Samir Gupta, Joseph Fayad, Adriana M. Hung, Jack Lichy, Robin A. Hurley, R. Brooks Robey, Rob Striker,
Background: Familial hypercholesterolemia (FH) is characterized by inherited high levels of LDL-C (low-density lipoprotein cholesterol) and premature coronary heart disease. Over a thousand low-frequency variants in LDLR, APOB, and PCSK9 have been implicated in FH, but few have been examined at the population level. We aim to estimate the phenotypic effects of a subset of FH variants on LDL-C and clinical outcomes among 331 107 multiethnic participants. Methods: We examined the individual and collective ...
Tópico(s): Genetic Associations and Epidemiology
2018 - Wolters Kluwer | Circulation Genomic and Precision Medicine
Huaying Fang, Qin Hui, Julie A. Lynch, Jacqueline Honerlaw, Themistocles L. Assimes, Jie Huang, Marijana Vujković, Scott M. Damrauer, Saiju Pyarajan, J. Michael Gaziano, Scott L. DuVall, Christopher J. O’Donnell, Kelly Cho, Kyong–Mi Chang, Peter W.F. Wilson, Philip S. Tsao, Yan V. Sun, Hua Tang, J. Michael Gaziano, Rachel Ramoni, Jim Breeling, Kyong–Mi Chang, Grant D. Huang, Sumitra Muralidhar, Christopher J. O’Donnell, Philip S. Tsao, Sumitra Muralidhar, Jennifer Moser, Stacey B. Whitbourne, Jessica V. Brewer, John Concato, Stuart Warren, Dean P. Argyres, Brady Stephens, Mary T. Brophy, Donald E. Humphries, Nhan Do, Shahpoor Shayan, Xuan‐Mai T. Nguyen, Saiju Pyarajan, Kelly Cho, Elizabeth R. Hauser, Yan V. Sun, Hongyu Zhao, Peter W.F. Wilson, Rachel McArdle, Louis J. Dell’Italia, John B. Harley, Jeff Whittle, Jean C. Beckham, John A. Wells, Salvador Gutierrez, Gretchen Gibson, Laurence S. Kaminsky, Gerardo Villareal, Scott Kinlay, Junzhe Xu, Mark B. Hamner, Kathlyn Sue Haddock, Sujata Bhushan, Pran Iruvanti, Michael Godschalk, Zuhair K. Ballas, Malcolm Buford, Stephen Mastorides, Jon Klein, Nora Ratcliffe, Hermes Flórez, Alan C. Swann, Maureen Murdoch, Peruvemba Sriram, Shing Shing Yeh, Ronald G. Washburn, Darshana Jhala, Samuel M. Aguayo, David Cohen, Satish Sharma, John Callaghan, Kris Ann Oursler, Mary A. Whooley, Sunil K. Ahuja, Amparo Gutierrez, Ronald Schifman, Jennifer Greco, Michael Rauchman, Richard J. Servatius, Mary E. Oehlert, Agnes Wallbom, Ronald Fernando, Timothy R. Morgan, Todd Stapley, Scott E. Sherman, Gwenevere Anderson, Elif Sonel, Edward J. Boyko, Laurence Meyer, Samir Gupta, Joseph Fayad, Adriana M. Hung, Jack Lichy, Robin A. Hurley, R. Brooks Robey, Rob Striker,
Large-scale multi-ethnic cohorts offer unprecedented opportunities to elucidate the genetic factors influencing complex traits related to health and disease among minority populations. At the same time, the genetic diversity in these cohorts presents new challenges for analysis and interpretation. We consider the utility of race and/or ethnicity categories in genome-wide association studies (GWASs) of multi-ethnic cohorts. We demonstrate that race/ethnicity information enhances the ability to understand ...
Tópico(s): Genetic Mapping and Diversity in Plants and Animals
2019 - Elsevier BV | The American Journal of Human Genetics
Derek Klarin, Shefali S. Verma, Renae Judy, Ozan Dikilitas, Brooke N. Wolford, Ishan Paranjpe, Michael G. Levin, Cuiping Pan, Catherine Tcheandjieu, Joshua M. Spin, Julie A. Lynch, Themistocles L. Assimes, Linn Åldstedt Nyrønning, Erney Mattsson, Todd L. Edwards, Joshua C. Denny, Eric B. Larson, Ming Ta Michael Lee, David Carrell, Yanfei Zhang, Gail P. Jarvik, Ali G. Gharavi, John B. Harley, Frank Mentch, Jennifer A. Pacheco, Hákon Hákonarson, Anne Heidi Skogholt, Laurent F. Thomas, Maiken E. Gabrielsen, Kristian Hveem, Jonas B. Nielsen, Wei Zhou, Lars G. Fritsche, Jie Huang, Pradeep Natarajan, Yan V. Sun, Scott L. DuVall, Daniel J. Rader, Kelly Cho, Kyong–Mi Chang, Peter W.F. Wilson, Christopher J. O’Donnell, Sekar Kathiresan, Salvatore T. Scali, Scott A. Berceli, Cristen J. Willer, Gregory T. Jones, Matthew J. Bown, Girish N. Nadkarni, Iftikhar J. Kullo, Marylyn D. Ritchie, Scott M. Damrauer, Philip S. Tsao, J. Michael Gaziano, Rachel Ramoni, Jean C. Beckham, Jim Breeling, Kyong–Mi Chang, Grant D. Huang, Sumitra Muralidhar, Christopher J. O’Donnell, Jonathan Romero, Philip S. Tsao, Sumitra Muralidhar, Jennifer Moser, Stacey B. Whitbourne, Jessica V. Brewer, John Concato, Stuart Warren, Dean P. Argyres, Philip S. Tsao, J. Michael Gaziano, Brady Stephens, Mary T. Brophy, Donald E. Humphries, Nhan Do, Shahpoor Shayan, Xuan‐Mai T. Nguyen, Christopher J. O’Donnell, Saiju Pyarajan, Philip S. Tsao, Kelly Cho, Saiju Pyarajan, Elizabeth R. Hauser, Yan V. Sun, Hongyu Zhao, Peter W.F. Wilson, Rachel McArdle, Louis J. Dell’Italia, John B. Harley, Clement J. Zablocki, Jeff Whittle, Jean C. Beckham, John A. Wells, Salvador Gutierrez, Gretchen Gibson, Laurence S. Kaminsky, Gerardo Villareal, Scott Kinlay, Junzhe Xu, Mark B. Hamner, Kathlyn Sue Haddock, Sujata Bhushan, Pran Iruvanti, Michael Godschalk, Zuhair K. Ballas, Malcolm Buford, Stephen Mastorides, Jon Klein, Nora Ratcliffe, Hermes Flórez, Alan C. Swann, Maureen Murdoch, Peruvemba Sriram, Shing Shing Yeh, Ronald G. Washburn, Darshana Jhala, Samuel M. Aguayo, David Cohen, Satish Sharma, John Callaghan, Kris Ann Oursler, Mary A. Whooley, Sunil K. Ahuja, Amparo Gutierrez, Ronald Schifman, Jennifer Greco, Michael Rauchman, Richard J. Servatius, Mary E. Oehlert, Agnes Wallbom, Ronald Fernando, Timothy R. Morgan, Todd Stapley, Scott E. Sherman, Gwenevere Anderson, Philip S. Tsao, Elif Sonel, Edward J. Boyko, Laurence Meyer, Samir Gupta, Joseph Fayad, Adriana M. Hung, Jack Lichy, Robin A. Hurley, R. Brooks Robey, Rob Striker,
Abdominal aortic aneurysm (AAA) is an important cause of cardiovascular mortality; however, its genetic determinants remain incompletely defined. In total, 10 previously identified risk loci explain a small fraction of AAA heritability.We performed a genome-wide association study in the Million Veteran Program testing ≈18 million DNA sequence variants with AAA (7642 cases and 172 172 controls) in veterans of European ancestry with independent replication in up to 4972 cases and 99 858 controls. We ...
Tópico(s): Connective tissue disorders research
2020 - Lippincott Williams & Wilkins | Circulation
Akihito Kawazoe, Rui‐Hua Xu, Pilar García‐Alfonso, Maria Passhak, Hao‐Wei Teng, Ardaman Shergill, Mahmut Gümüş, Camilla Qvortrup, Sebastian Stintzing, Kathryn Towns, Tae Won Kim, Kai‐Keen Shiu, Juan Cundom, Sumitra Ananda, A. A. Lebedinets, Rong Fu, Rishi Jain, David E. Adelberg, Volker Heinemann, Takayuki Yoshino, Elena Élez, Juan Cundom, Ezequiel Slutsky, Julieta Grasselli, Luis Fein, Luciana Bella Quero, Warren Joubert, Peter Gibbs, Timothy Price, Matthew Burge, Sumitra Ananda, Muhammad A. Khattak, Bruce Colwell, Félix Couture, Brandon M. Meyers, Kathryn Towns, Michael B. Sawyer, Lucas Sidéris, Rui‐Hua Xu, Wei Wang, Hongming Pan, Per Pfeiffer, Lars Henrik Jensen, Camilla Qvortrup, Sebastian Stintzing, Dirk Arnold, Sylvie Lorenzen, Stefan Kubicka, Reinhard Depenbusch, Maria Passhak, Ravit Geva, Ayala Hubert, Einat Shacham‐Shmueli, Gleb Kornev, Akihito Kawazoe, Toshiki Masuishi, Atsuo Takashima, Hiroki Hara, Hisato Kawakami, Nozomu Machida, Kentaro Yamazaki, Hisateru Yasui, Akihito Tsuji, Taito Esaki, Kensei Yamaguchi, Tae‐You Kim, Joong Bae Ahn, Myung Ah Lee, Tae Won Kim, Joon Oh Park, Soo Hyun Lee, Р. В. Орлова, Vladislav O. Sarzhevskiy, Marina Sekacheva, S. Tjulandin, Oksana Shirokova, A.I. Iskhakova Iskhakova, A. A. Lebedinets, Paula Jiménez Fonseca, F. Rivera Herrero, Elena Élez, Pilar Alfonso, M.J. Gómez Reina, Kun‐Huei Yeh, Hao‐Wei Teng, Tsai Sheng Yang, Hwei‐Ming Wang, Yu‐Min Yeh, Mustafa Özgüroğlu, Mahmut Gümüş, Şuayib Yalçın, Bülent Erdoğan, Umut Demırcı, Pınar Gürsoy, Hakan Harputluoğlu, Atakan Demir, Kai‐Keen Shiu, Ewan Brown, Paul J. Ross, Elizabeth Smyth, Ian Chau, Mark Saunders, Gina M. Vaccaro, Steven McCune, Raymond Wadlow, Gazala Khan, Babar Bashir, Michael D. Koontz, Ludmila Martin, Ardaman Shergill, Patrick Cobb, Mark D. Kochenderfer,
Treatment options are limited for patients with previously treated metastatic colorectal cancer (mCRC). In the LEAP-017 study, we evaluate whether lenvatinib in combination with pembrolizumab improves outcomes compared with standard of care (SOC) in previously treated mismatch repair proficient or not microsatellite instability high (pMMR or not MSI-H) mCRC.
Tópico(s): Colorectal Cancer Surgical Treatments
2024 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
Niamh Mullins, Jooeun Kang, Adrián I. Campos, Jonathan R. I. Coleman, Alexis C. Edwards, Hanga Galfalvy, Daniel F. Levey, Adriana Lori, Andrey A. Shabalin, Anna Starnawska, Mei-Hsin Su, Hunna J. Watson, Mark J. Adams, Swapnil Awasthi, Michael J. Gandal, Jonathan D. Hafferty, Akitoyo Hishimoto, Minsoo Kim, Satoshi Okazaki, Ikuo Otsuka, Stephan Ripke, Erin B. Ware, Andrew W. Bergen, Wade H. Berrettini, Martin Bohus, Harry Brandt, Xiao Chang, Wei J. Chen, Hsi‐Chung Chen, Steven Crawford, Scott J. Crow, Emily DiBlasi, Philibert Duriez, Fernando Fernández‐Aranda, Manfred M. Fichter, Steven Gallinger, Stephen J. Glatt, Philip Gorwood, Yiran Guo, Hakon Hakonarson, Katherine A. Halmi, Hai‐Gwo Hwu, Sonia Jain, Stéphane Jamain, Susana Jiménez‐Múrcia, Craig Johnson, Allan S. Kaplan, Walter H. Kaye, Pamela K. Keel, James L. Kennedy, Kelly Klump, Dong Li, Shih‐Cheng Liao, Klaus Lieb, Lisa Lilenfeld, Chih‐Min Liu, Pierre J. Magistretti, Christian R. Marshall, James E. Mitchell, Eric T. 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Suicide is a leading cause of death worldwide, and nonfatal suicide attempts, which occur far more frequently, are a major source of disability and social and economic burden. Both have substantial genetic etiology, which is partially shared and partially distinct from that of related psychiatric disorders.
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