Mika Shirao, Riko Furuta, Sumiko Suzuki, Hiroyuki Nakazawa, Susumu Fujita, Toshihiko Maruyama,
The simultaneous measurement of organic acids was studied using capillary electrophoresis with direct measurement of UV absorption at 185 nm. The organic acids studied were oxalic, formic, malonic, fumaric, succinic, α-ketoglutaric, citric, acetic, pyruvic, lactic, isovaleric and hippuric acid. They were separated in a fused-silica capillary (100 cni × 75 μm I.D.) filled with 50 mM borax buffer (pH 10.0) containing cationic surfactant as the electroosmotic flow modifier. The method was successfully ...
Tópico(s): Analytical Chemistry and Chromatography
1994 - Elsevier BV | Journal of Chromatography A
Stephen M. Erlien, Susumu Fujita, J. Christian Gerdes,
Steer-by-wire technology enables vehicle safety systems to share control with a driver through augmentation of the driver's steering commands. Advances in sensing technologies empower these systems further with real-time information about the surrounding environment. Leveraging these advancements in vehicle actuation and sensing, the authors present a shared control framework for obstacle avoidance and stability control using two safe driving envelopes. One of these envelopes is defined by the vehicle ...
Tópico(s): Real-time simulation and control systems
2015 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Intelligent Transportation Systems
Stephen M. Erlien, Susumu Fujita, J. Christian Gerdes,
Leveraging new technology in vehicle actuation and sensing, the authors present a control framework for obstacle avoidance and stability control using safe driving envelopes. One of these envelopes is defined by the vehicle handling limits and the other is based on spatial limitations imposed by the environment. A Model Predictive Control (MPC) scheme determines at each time step if the current driver command allows for a safe vehicle trajectory within these two envelopes, intervening only when such ...
Tópico(s): Robotic Path Planning Algorithms
2013 - Elsevier BV | IFAC Proceedings Volumes
Noriyuki Kato, Susumu Fujita, Hikoto Ohta, Makoto Fukuba, Akira Toriba, Kazuichi Hayakawa,
A rapid and sensitive method for the detection of six methylenedioxylatedphenethylamines, 3,4-methylenedioxymethamphetamine (MDMA); 3,4-methylenedioxyamphetamine; 3,4-methylenedioxyethylamphetamine; N-methyl-1-(3,4-methylenedioxyphenyl)-2-butamine; N-methyl-1-(3,4-methylenedioxyphenyl)-3-butamine; and 3,4-methylenedioxydimethylamphetamine, by thin-layer chromatography with fluorescence detection is proposed. These compounds form fluorophores on the developing plate following spraying with a reagent ...
Tópico(s): Neurotransmitter Receptor Influence on Behavior
2008 - Wiley | Journal of Forensic Sciences
Yukitaka Miyachi, WAKA JITSUISHI, Akima Miyoshi, Susumu Fujita, Akira Mizuchi, Kazuhiko Tatemoto,
The distribution of peptide YY (PYY)-like immunoreactivity (IR) in rat tissues was determined by specific RIA after extraction with boiled 1 N acetic acid. The high concentration of PYY-IR was observed in the gastrointestinal tract, with concentrations gradually increasing from the duodenum to the end of colon. The concentration of PYY-IR in the colon was 298.7-449.5 pmol/g tissue (approximately 100-200 times more than that in the duodenum). Pituitary and pancreas contained measurable amounts of PYY- ...
Tópico(s): Regulation of Appetite and Obesity
1986 - Oxford University Press | Endocrinology
Masanobu Fujita, Susumu Ito, Atsutoshi Ota, Nobuharu Kato, Kōji Yamamoto, Yoichi Kawashima, Hideyasu Yamauchi, Jun-ichi Iwao,
... 4-methyl-3-oxo-2H-1,4-benzothiazinesMasanobu Fujita, Susumu Ito, Atsutoshi Ota, Nobuharu Kato, Koji Yamamoto, Yoichi ...
Tópico(s): Synthesis and Characterization of Heterocyclic Compounds
1990 - American Chemical Society | Journal of Medicinal Chemistry
Hirofumi Matsuo, Nobuyuki Hayashi, Tomomi Ujihara, Susumu Fujita, Toshihiro Tatsuno, Masafumi Mitarai, Yoshinori Gejima, Yukio Toyomitsu, Osamu Kinoshita, Tomohiro Taniguchi,
釜炒り茶と煎茶の渋味について味覚センサーを用いて比較を行ったところ，釜炒り茶は煎茶よりも渋味が少ないこと，煎茶では蒸熱時間が長くなると渋味が緩和されることが明らかとなった．また味覚センサーでの渋味推定値を目的変数，浸出液のカテキンおよび水溶性ペクチン含有量を説明変数として重回帰分析を行った結果，渋味は浸出液のカテキンおよび水溶性ペクチン含有量で説明でき，カテキン含有量が多いほど，水溶性ペクチン含有量が少ないほど渋味が強くなることが判明した．浸出液のカテキンおよび水溶性ペクチン含有量は，釜炒り茶よりも煎茶で多く，水溶性ペクチンの溶出割合は，釜炒り茶よりも煎茶で高い結果となったが，これは茶葉に対して釜炒り茶の製茶工程では，煎茶ほど揉圧が加えられないためと考えられた．また茶葉中の水溶性ペクチンは，蒸熱時間が長くなると増加し，恒率乾燥が保たれる殺青以降の工程では明確な増加がみられないことから，茶葉が90～100℃程度に加熱される工程で増加するものと推察された．
Tópico(s): Ziziphus Jujuba Studies and Applications
2012 - Japanese Society for Food Science and Technology | Nippon Shokuhin Kagaku Kogaku Kaishi
Hideo Kawamura, Masahiro Manabe, Yukio Miyamoto, Yoshiki Fujita, Susumu Tokunaga,
... sulfate micellesHideo Kawamura, Masahiro Manabe, Yukio Miyamoto, Yoshiki Fujita, and Susumu TokunagaCite this: J. Phys. Chem. 1989, 93, 14, ...
Tópico(s): Thermodynamic properties of mixtures
1989 - American Chemical Society | The Journal of Physical Chemistry
Susumu Imaoka, Shoichi Fujita, Yoshihiko Funae,
Age-related changes in the levels of multiple forms of cytochrome P-450 as well as in the testosterone hydroxylation activities of hepatic microsomes of male and female rats of different ages from 1 week to 104 weeks (24 months) were investigated. The total cytochrome P-450 measured photometrically did not change much with age in either male and female rats. Testosterone 2 alpha-, 2 beta-, 6 beta-, 15 alpha-, 16 beta-hydroxylation activities of male rats were much higher than those in female rats ...
Tópico(s): Hormonal Regulation and Hypertension
1991 - Elsevier BV | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Tatsuya Shono, Yoshihiro Matsumura, Susumu Katoh, Tetsuhiro Fujita, Tohru Kamada,
Anodic oxidation of easily accessible alkyl aryl ketones 1 in trimethyl orthoformate containing a small amount of iodine or organo-iodo compounds gave methyl α-arylalkanoates 2 in high yields.
Tópico(s): Electrochemical Analysis and Applications
1989 - Elsevier BV | Tetrahedron Letters
Susumu Ohmura, Susumu HORIMOTO, K. Fujita,
Lectin-gold complexes in the dark granules (DGs) and the dense substance (DS) of vallate taste buds were localized. Both the DGs and the DS were labelled with wheat-germ agglutinin, Ulex europeus agglutinin-I and peanut agglutinin. Their common reaction to these lectins suggested that the DGs contain carbohydrate components similar to those of the DS. The results provide cytochemical evidence that the DS in the taste pit represents, at least in part, the content of the DGs in the type 1 cells.
Tópico(s): Analytical Chemistry and Chromatography
1989 - Elsevier BV | Archives of Oral Biology
Saburo Kojima, HIDEO FUKUMI, Hideo Kusama, Shigeo Yamamoto, Shoichiro Suzuki, Tatsuji Uchida, TAKAJI ISHIMARU, Toru Oka, Kazuo Kuretani, KEIKO OHMURA, FUMIO NISHIKAWA, Susumu Fujimoto, Kozo Fujita, AIKO NAKANO, Sumiko Sunakawa,
Tópico(s): Viral Infections and Vectors
1948 - | Japanese medical journal
Yuta Yako, Takashi Hayashi, Yasuto Takeuchi, Kojiro Ishibashi, Nobuhiro Kasai, Nanami Sato, Keisuke Kuromiya, Susumu Ishikawa, Yasuyuki Fujita,
Abstract Recent studies have revealed that newly emerging transformed cells are often eliminated from epithelia via cell competition with the surrounding normal epithelial cells. However, it remains unknown whether and how soluble factors are involved in this cancer preventive phenomenon. By performing stable isotope labeling with amino acids in cell culture (SILAC)-based quantitative mass spectrometric analyses, we have identified ADAM-like Decysin-1 (ADAMDEC1) as a soluble protein whose expression ...
Tópico(s): Cell Adhesion Molecules Research
2018 - Nature Portfolio | Scientific Reports
Atsuko Ohoka, Mihoko Kajita, Junichi Ikenouchi, Yuta Yako, Sho Kitamoto, Shunsuke Kon, Masaya Ikegawa, Takashi Shimada, Susumu Ishikawa, Yasuyuki Fujita,
At the initial stage of carcinogenesis, a mutation occurs in a single cell within a normal epithelial layer. We have previously shown that RasV12-transformed cells are apically extruded from the epithelium when surrounded by normal cells. However, the molecular mechanisms underlying this phenomenon remain elusive. Here, we demonstrate that Cav-1-containing microdomains and EPLIN are accumulated in RasV12-transformed cells that are surrounded by normal cells. We also show that knockdown of Cav-1 ...
Tópico(s): Hippo pathway signaling and YAP/TAZ
2015 - The Company of Biologists | Journal of Cell Science
Hiroshi Osaka, Koichi Shinkoda, Susumu Watanabe, Daisuke Fujita, Hiroshi Ishida, Kenichi Kobara, Yosuke Yoshimura, Tomotaka Ito,
[Purpose] The purpose of this study was to investigate the validity of an evaluation index of the vertical (VT), anteroposterior (AP), and mediolateral (ML) directions of trunk acceleration during walking. [Methods] Twenty-nine subjects volunteered for this study. Trunk acceleration and ground reaction force (GRF) during normal walking were measured. The root mean square (RMS), stride regularity (SR), and step symmetry (SS) were calculated on the basis of trunk acceleration. The displacement of COG was ...
Tópico(s): Cerebral Palsy and Movement Disorders
2013 - Penerbit Universiti Sains Malaysia | Journal of Physical Therapy Science
Tópico(s): Optical Coatings and Gratings
2009 - Nature Portfolio | Nature Photonics
Takashi Nakahara, Ryosuke Tsuruta, Tadashi Kaneko, Susumu Yamashita, Motoki Fujita, Shunji Kasaoka, Teruto Hashiguchi, Michiyasu Suzuki, Ikuro Maruyama, Tsuyoshi Maekawa,
Tópico(s): S100 Proteins and Annexins
2009 - Springer Science+Business Media | Neurocritical Care
Susumu Noda, Masayuki Fujita, Takashi Asano,
Tópico(s): Plasmonic and Surface Plasmon Research
2007 - Nature Portfolio | Nature Photonics
Masataka Hidaka, Akio Goto, Susumu Umino, Eisuke Fujita,
The lava flow simulation code LavaSIM has been developed to give accurate predictions of volcanic disasters and to support evacuation plans. The code uses three‐dimensional analysis with free surface evaluation, including boundary transport between the melt and the crust. It is therefore applicable to various types of lava flows and flow behaviors such as flood basalts, subaqueous lava flows, and levee formation. Heat transfer between the lava and the ground, air, and water, and between the melt ...
Tópico(s): earthquake and tectonic studies
2005 - Wiley | Geochemistry Geophysics Geosystems
Tomoya Sudo, Susumu Sueyoshi, Hiromasa Fujita, Hideaki Yamana, Kazuo Shirouzu,
A 73-year-old woman complaining of sudden hoarseness visited our hospital 17 days after the onset. The upper gastrointestinal contrast study showed a shallow ulcer crater with moderate bulging in the upper thoracic esophagus. Endoscope and computed tomography revealed an esophageal foreign body, a Press Through Pack (PTP), in the esophageal ulcer. The PTP could be removed endoscopically. Two months after extraction of the PTP, the patient was taking normal food orally and was discharged. The esophageal ...
Tópico(s): Tracheal and airway disorders
2003 - Oxford University Press | Diseases of the Esophagus
Susumu Rokudai, Naoya Fujita, Osamu Kitahara, Yusuke Nakamura, Takashi Tsuruo,
Chemotherapeutic drugs exhibit their cytotoxic effect by inducing apoptosis in tumor cells. Because the serine/threonine kinase Akt is involved in apoptosis suppression, we investigated the relationship between Akt activity and drug sensitivity. We discovered that certain chemotherapeutic drugs induced apoptosis with caspase activation only when Akt was inactivated after drug treatment, while inactivation of Akt was not observed when tumor cells showed resistance to the drug-induced caspase activation. ...
Tópico(s): Cell death mechanisms and regulation
2002 - Taylor & Francis | Molecular and Cellular Biology
Susumu Tomita, Takashi Fujita, Yutaka Kirino, Toshiharu Suzuki,
It is widely believed that one of the causes of Alzheimer's disease (AD) is the generation and secretion of beta-amyloid (Abeta) from amyloid precursor protein in the brain. Here we report that a transcription factor, NF-kappaB/p65, induces increased secretion of amyloidogenic Abeta42 but not Abeta40. The kappaB motif-dependent production of Abeta42 was suppressed by binding of NF-kappaB/p65 to the PDZ domain of the X11-like protein (X11L), which a human homologue protein of LIN-10. The results suggest ...
Tópico(s): Hippo pathway signaling and YAP/TAZ
2000 - Elsevier BV | Journal of Biological Chemistry
Teruhiko Fujii, Hideaki Yamana, Susumu Sueyoshi, Hiromasa Fujita, Yoshiaki Tanaka, M. Kubota, Uhi Toh, Takasi Mine, Hisako Sasahara, Kazuo Shirouzu, Shunsuke Kato, Minoru Morimatsu,
We studied the premalignant nature of achalasia using anti-Ki-67 and anti-p53 monoclonal antibodies immunohistochemically. In this study, four patients with esophageal carcinoma and achalasia were investigated. Three tumors were pT4 (UICC pTNM) and one tumor was pT1. The majority of non-malignant esophageal epithelium showed esophagitis and/or dysplasia histologically. Esophageal epithelial cells in the lesions of esophagitis and/or dysplasia had a higher number of Ki-67-positive cells than normal ...
Tópico(s): Esophageal and GI Pathology
2000 - Oxford University Press | Diseases of the Esophagus
Susumu Rokudai, Naoya Fujita, Yuichi Hashimoto, Takashi Tsuruo,
The oncogene Akt/PKB/RAC-PK is a serine/threonine kinase that mediates survival signals and has protective effects against apoptosis induced by a variety of stimuli. The kinase activity of Akt has been demonstrated to be critical in transmitting survival signals. We found that Akt protein was down-regulated during apoptosis. The down-regulation was blocked by a caspase inhibitor, indicating that Akt was cleaved by caspases during apoptosis. The Akt protein incubation with active caspases in vitro ...
Tópico(s): Cancer Mechanisms and Therapy
2000 - Wiley | Journal of Cellular Physiology
Susumu Sugaya, Kazuyuki Fujita, Akira Kikuchi, Hiroyuki Ueda, Koichi Takakuwa, Shoji Kodama, Kenichi Tanaka,
To establish the expression of the herpes simplex virus thymidine kinase (HSV-TK) gene in tumor cells, we analyzed the promoter function of the SV40 promoter and the nucleotide sequence (CACGTG) to which Myc-Max heterodimers (Myc/Max) were capable of binding in four kinds of cell lines: COLO320 DM, A-431, KF, and Nakajima. When luciferase reporter plasmid under the control of SV40 promoter was transfected into tumor cells in vitro, a high level of luciferase activity was observed in all kinds of cell ...
Tópico(s): Herpesvirus Infections and Treatments
1996 - Mary Ann Liebert, Inc. | Human Gene Therapy
A variety of grafts have been used for lining the temporomandibular joint (TMJ) after the resection of an ankylotic mass, but no consensus has been reached as to the most suitable material. The temporalis muscle and fascia (TMF) flap has been widely used as an interpositional graft after the release of TMJ ankylosis because of its advantages over other types of materials, including autogenous dermis and cartilage, and alloplastic materials such as Proplast-Teflon and Silastic.’ Among the advantages ...
Tópico(s): Facial Nerve Paralysis Treatment and Research
1996 - Elsevier BV | Journal of Oral and Maxillofacial Surgery
Susumu Katano, Osamu Fujita, Jun Akimitsu, Masakazu Nishi,
The dimerization in the spin-Peierls state of CuGe${\mathrm{O}}_{3}$ has been studied by neutron diffraction under high pressures up to 1.65 GPa. Effects of pressure on the chain direction along the $c$ axis are fairly small; however, the dimerization of Cu along this direction tends to decrease. In comparison with this small change, the effects on the oxygen displacements in the $\mathrm{ab}$ plane are rather large. The shift of oxygen atoms decreases also along the $a$ axis; on the other hand, the ...
Tópico(s): Theoretical and Computational Physics
1995 - American Physical Society | Physical review. B, Condensed matter
Susumu Hashimoto, Masanori Fujita, Kenji Furukawa, Junichi Minami,
Tópico(s): Advanced Chemical Sensor Technologies
1987 - Elsevier BV | Journal of Fermentation Technology
Susumu Hashimoto, Masanori Fujita,
Tópico(s): Biofuel production and bioconversion
1985 - Elsevier BV | Journal of Fermentation Technology
Yasumasa J. I’Haya, Susumu Narita, Y Fujita, H. Ujino,
Ab initio crystal orbital calculations with extended basis sets and model potentials are performed for one-dimensional periodic systems. The results of restricted Hartree–Fock-type calculation for all-trans polyacetylene (CH)n and linear and bent hydrogen-bonded poly(hydrogen fluoride) (HF)n are mainly reported. The results, in particular total energies per unit cell, are shown to be much more dependent upon the basis sets than on the method of lattice-sum truncation, number of k points, or order ...
Tópico(s): Solid-state spectroscopy and crystallography
1984 - Wiley | International Journal of Quantum Chemistry