Mari S. Golub, Lucio G. Costa, Kevin M. Crofton, Deborah A. Frank, Peter A. Fried, Beth C. Gladen, Rogene Henderson, Erica L. Liebelt, Shari I. Lusskin, Sue Marty, Andrew S. Rowland, John V. Scialli, Mary Vore,
... of Health. Gadow KD, Nolan E, Sprafkin J, Sverd J. 1995a. School observations of children with attention- ... Dev Behav Pediatr 16: 167–176. Gadow KD, Sverd J, Sprafkin J, Nolan EE, Ezor SN. 1995b. ... 944–947. Hungund BL, Perel JM, Hurwic MJ, Sverd J, Winsberg BG. 1979. Pharmacokinetics of methylphenidate in ... hyperactive children? Nord J Psychiatry 56: 53–57. Sverd J, Gadow KD, Paolicelli LM. 1989. Methylphenidate treatment ...
Tópico(s): Pharmaceutical studies and practices
2005 - Wiley | Birth Defects Research
Jeffrey Sverd, Samuel S. Kupietz, Bertrand G. Winsberg, Maria Hurwic, Laura Becker,
Behavioral effects of L-5-Hydroxytryptophan (L-5-HTP), administered in combination with carbidopa, were evaluated in three autistic children using direct behavioral observation and parent ratings. Children were assessed under each of four experimental conditions: Baseline, Placebo I, L-5-HTP plus carbidopa, and Placebo II. During the 20-week study two children showed behavioral change that appeared to be unrelated to drug treatment. The findings did not support the hypothesis that a functional deficit ...
Tópico(s): Autism Spectrum Disorder Research
1978 - Springer Science+Business Media | Journal of Autism and Childhood Schizophrenia
J A Camp, Irv Bialer, Jeffrey Sverd, Bertrand G. Winsberg,
Tópico(s): Traumatic Brain Injury and Neurovascular Disturbances
1978 - American Psychiatric Association | American Journal of Psychiatry
Oliver J. David, Stanley P. Hoffman, Jeffrey Sverd, Julian Clark,
Tópico(s): Heavy Metal Exposure and Toxicity
1977 - Springer Science+Business Media | Journal of Abnormal Child Psychology
Olivier David, Stanley P. Hoffman, Jeffrey Sverd, Jeffrey R. Clark, Kytja K. S. Voeller,
Lead-chelating medication was used to treat 13 hyperkinetic school children whose blood and urine lead levels were in an elevated but "nontoxic" range. Six children with histories of etiologically relevant perinatal or developmental complications showed relatively little improvement. Seven other children with unremarkable histories, and for whom a lead etiology could thus be entertained, showed marked improvement. The authors conclude that lead may play an important role in the etiology of some cases ...
Tópico(s): Pharmaceutical studies and practices
1976 - American Psychiatric Association | American Journal of Psychiatry
Bertrand G. Winsberg, Jeffrey Sverd, S Castells, Maria Hurwic, J M Perel,
A group of autistic children had the concentrations of spinal fluid 5-HIAA, HVA and cAMP studied before and twenty-four hours after afflux blockade with probenecid. Spinal fluid aminoacids were studied before probenecid administration and found to be normal. Three children lacked an increase in the concentration of 5-HIAA after probenecid administration, and two had only modest increases in the concentration of spinal fluid HVA. The concentration of spinal fluid cAMP was increased by probenecid ...
Tópico(s): Childhood Cancer Survivors' Quality of Life
1980 - Thieme Medical Publishers (Germany) | Neuropediatrics
Tópico(s): Neurology and Historical Studies
1979 - American Psychiatric Association | American Journal of Psychiatry
B L Hungund, Perel Jm, Hurwic Mj, Jeffrey Sverd, B G Winsberg,
1 Pharmacokinetic study has been carried out following oral administration of 10-20 mg of methylphenidate hydrochloride to four behaviorally disorders children. 2 It is indicated that the drug is metabolized to ritalinic acid with an apparent plasma half life of 2.5 h. 3 The variability in magnitude of plasma concentration seems to be due not to its metabolism to ritalinic acid but due to the variability in the apparent volume of distribution. 4 The brief half life of methylphenidate which parallels ...
Tópico(s): Pharmaceutical studies and practices
1979 - Wiley | British Journal of Clinical Pharmacology
Samuel S. Kupietz, Bertrand G. Winsberg, Jeffrey Sverd,
Tópico(s): Attention Deficit Hyperactivity Disorder
1982 - Yale University Press | Journal of the American Academy of Child Psychiatry
Bertrand G. Winsberg, Samuel S. Kupietz, Jeffrey Sverd, Basalingappa L. Hungund, Nancy L. Young,
Tópico(s): Attention Deficit Hyperactivity Disorder
1982 - Springer Science+Business Media | Psychopharmacology
Oliver J. David, Stanley P. Hoffman, Julian Clark, G.A. Grad, Jeffrey Sverd,
ABSTRACT Controversy exists with respect to whether moderately elevated lead levels are toxic in certain children with various central nervous system dysfunctions. One way of addressing this controversy is to remove the lead; if the condition is ameliorated a presumption of toxicity becomes reasonable. Such a strategy is reported herein. Children with an operationally defined central nervous system dysfunction (hyperactivity) and moderately elevated lead levels were treated with a lead chelating ...
Tópico(s): Trace Elements in Health
1983 - Heldref Publications | Archives of Environmental Health An International Journal
Maurice S. Satin, Bertrand G. Winsberg, CHARLOTTE H. MONETTI, Jeffrey Sverd, Daniel A. Foss,
Tópico(s): Child and Adolescent Psychosocial and Emotional Development
1985 - Yale University Press | Journal of the American Academy of Child Psychiatry
Kenneth D. Gadow, Edith E. Nolan, Jeffrey Sverd, Joyce Sprafkin, Lucia M. Paolicelli,
One of the least documented "known" effects of methylphenidate in hyperactive children is the suppression of peer aggression. In this study, 11 aggressive-hyperactive children received a low (0.3 mg/kg) and moderate (0.6 mg/kg) dose of methylphenidate and placebo for 2 weeks each under double-blind conditions. Children were observed in public school settings during classroom seatwork activities, lunch, and recess. Results showed that methylphenidate suppressed nonphysical aggression (p = 0.06) in the ...
Tópico(s): Behavioral and Psychological Studies
1990 - Elsevier BV | Journal of the American Academy of Child & Adolescent Psychiatry
Jeffrey Sverd, Kenneth D. Gadow, Lucia M. Paolicelli,
Abstract The effects of methylphenidate on four boys diagnosed as attention-deficit hyperactivity disorder (ADHD) and Tourette's syndrome (TS) were examined under single-blind, placebo-controlled conditions. Clinical ratings and playroom observations showed improvement in ADHD symptoms with methylphenidate. Results also indicated that methylphenidate had no untoward effects on the frequency of tic occurrence. In all four children, the highest dose resulted in improved classroom ratings of tics compared with ...
Tópico(s): Eating Disorders and Behaviors
1989 - Elsevier BV | Journal of the American Academy of Child & Adolescent Psychiatry
Jeffrey Sverd, Alison D. Curley, Lina Jandorf, LINDA VOLKERSZ,
Behavior disorders in a group of Tourette syndrome (TS) boys and in a group of boys referred with behavior difficulties only were compared. The two groups were similar with regard to teacher and parent ratings of behavior disturbance and with regard to clinical diagnoses of behavioral and attentional disorders. Over 90% of TS boys were diagnosed as having attention deficit disorder. Some boys with mild TS were found to have attentional and impulse control problems. Increased severity of TS symptoms ...
Tópico(s): Trypanosoma species research and implications
1988 - Elsevier BV | Journal of the American Academy of Child & Adolescent Psychiatry
... motor tics. Archives of Neurology, 40, 825–826. Sverd, J., Curley, A. D., Jandorf, L., & Volkersz, L. ( ...
Tópico(s): Neurology and Historical Studies
1991 - Wiley | Journal of Clinical Psychology
Abstract The histories of 10 children with autistic disorder or pervasive developmental disorder (PDD) cooccurring with familial Tourette syndrome (TS) are presented. Evidence from the histories of the patients and their relatives combined with other reports of cases of cooccurrence of TS and autism provides support for the hypothesis that TS may be responsible forcases of coocurrence of the disorders, contributes significantly to the etiological heterogeneity of autistic disorder and that a portion ...
Tópico(s): Virology and Viral Diseases
1991 - Wiley | American Journal of Medical Genetics
Kenneth D. Gadow, Lucia M. Paolicelli, Edith E. Nolan, Joseph E. Schwartz, Joyce Sprafkin, Jeffrey Sverd,
The present study examines the indirect "spillover" effects of methylphenidate on the behavior of the classmates of drug-treated children in public school settings, and it measures the extent to which medication normalizes hyperactive and noncompliant–aggressive behaviors. Eleven aggressive hyperactive boys, who met DSM-III diagnostic criteria for attention deficit disorder, received placebo and methylphenidate in a double-blind crossover design. Medication effects were assessed by conducting observations ...
Tópico(s): Cardiovascular and exercise physiology
1992 - Mary Ann Liebert, Inc. | Journal of Child and Adolescent Psychopharmacology
Kenneth D. Gadow, Edith E. Nolan, Jeffrey Sverd,
Abstract In this study, 11 prepubertal hyperactive boys with tic disorder received placebo and three doses of methylphenidate (0.1, 0.3, and 0.5 mg/kg) for 2 weeks each, under double-blind conditions. Each boy was observed for approximately 20 hours in the school setting (classroom seatwork activities, lunchroom, and playground). Results showed that methylphenidate effectively suppressed hyperactive/disruptive behaviors in the classroom and physical aggression in the lunchroom and on the playground. Methylphenidate ...
Tópico(s): Autism Spectrum Disorder Research
1992 - Elsevier BV | Journal of the American Academy of Child & Adolescent Psychiatry
Elizabeth Pappadopulos, Peter S. Jensen, Sarah B. Schur, James C. MacIntyre, Scott Ketner, Kate van Orden, Jeffrey Sverd, S Sardana, David Woodlock, Robert Schweitzer, David M. Rube,
This article examines the factors that influence antipsychotic use among youth treated in public inpatient facilities. By combining data from 11 focus groups, a survey of 43 researchers and clinicians, and a chart review of 100 closed patient charts, we investigated the interplay between physicians' and staff members' perceptions of problems related to antipsychotic prescribing, their beliefs concerning optimal approaches, their actual recorded prescribing behaviors, and the discrepancies between ...
Tópico(s): Pharmaceutical studies and practices
2002 - Oxford University Press | Schizophrenia Bulletin
Kenneth D. Gadow, Edith E. Nolan, Jeffrey Sverd, Joyce Sprafkin, Joseph E. Schwartz,
This study examined response to methylphenidate in children with attention-deficit/hyperactivity disorder (ADHD) and chronic multiple tic disorder. The primary goal was to determine if children with anxiety or depression symptoms showed a less favorable response to treatment. Subjects were 38 prepubertal children who participated in an 8-week, double-blind, placebo-controlled, methylphenidate crossover evaluation. Treatment effects were assessed with direct observations of child behavior in public ...
Tópico(s): Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
2002 - Lippincott Williams & Wilkins | Journal of Clinical Psychopharmacology
Pervasive developmental disorders (PDD) refer to the group of heterogeneous conditions that make up a continuum or spectrum of autistic disorders and share a core triad of impairments consisting of qualitative disturbances in social interaction and verbal and nonverbal communication and imagination. It has long been believed that the prevalence of autism was 2-4 per 10,000 children. However, studies using broader definitions of autistic disorder have suggested that the prevalence of autism spectrum ...
Tópico(s): Child Development and Digital Technology
2003 - Lippincott Williams & Wilkins | Journal of Psychiatric Practice
Elizabeth Pappadopulos, James C. MacIntyre, M. Lynn Crismon, Robert L. Findling, Richard P. Malone, Albert Derivan, Nina R. Schooler, Lin Sikich, Laurence L. Greenhill, Sarah B. Schur, Chip J. Felton, Harvey N. Kranzler, David M. Rube, Jeffrey Sverd, Molly Finnerty, Scott Ketner, Sonja E. Siennick, Peter S. Jensen,
Objective To develop treatment recommendations for the use of antipsychotic medications for children and adolescents with serious psychiatric disorders and externalizing behavior problems. Method Using a combination of evidence- and consensus-based methodologies, recommendations were developed in six phases as informed by three primary sources of information: (1) current scientific evidence (published and unpublished), (2) the expressed needs for treatment-relevant information and guidance specified ...
Tópico(s): Autism Spectrum Disorder Research
2003 - Elsevier BV | Journal of the American Academy of Child & Adolescent Psychiatry
Edith E. Nolan, Kenneth D. Gadow, Jeffrey Sverd,
Tópico(s): Eating Disorders and Behaviors
1994 - Springer Science+Business Media | Journal of Abnormal Child Psychology
Jeffrey Sverd, Rupa Sheth, Jared Fuss, Joseph Levine,
Tópico(s): Child Development and Digital Technology
1994 - Springer Science+Business Media | Child Psychiatry & Human Development
Kenneth D. Gadow, Edith E. Nolan, Jeffrey Sverd, Joyce Sprafkin, Jayne Schneider,
Our primary objective was to determine if immediate-release methylphenidate is an effective treatment for oppositional defiant disorder diagnosed from mother's report in children with both chronic multiple tic disorder and attention-deficit hyperactivity disorder (ADHD). Children (n = 31) aged 6 to 12 years received placebo and 3 doses of methylphenidate twice daily for 2 weeks each under double-blind conditions and were assessed with ratings scales and laboratory measures. Results indicated significant ...
Tópico(s): Autism Spectrum Disorder Research
2008 - SAGE Publishing | Journal of Child Neurology
Kenneth D. Gadow, Jeffrey Sverd, Edith E. Nolan, Joyce Sprafkin, Jayne Schneider,
Objective To examine the safety and efficacy of immediate-release methylphenidate (MPH-IR) for the treatment of attention-deficit/hyperactivity disorder (ADHD) in children (ages 6-12 years) with Tourette's syndrome (96%) or chronic motor tic disorder (4%). Method Two cohorts of prepubertal children (N = 71) received placebo and three doses of MPH (0.1, 0.3, and 0.5 mg/kg) twice daily for 2 weeks each, under double-blind conditions as part of their involvement in a long-term observation study (1989-2004). ...
Tópico(s): Autism Spectrum Disorder Research
2007 - Elsevier BV | Journal of the American Academy of Child & Adolescent Psychiatry
... Evans D, Klein D, MacMurray J, Tosk J, Sverd J, Gysin R, Flanagan S: The dopamine D ...
Tópico(s): Bipolar Disorder and Treatment
2006 - American Psychiatric Association | American Journal of Psychiatry
... Evans D, Klein D, MacMurray J, Tosk J, Sverd J, Gysin R, Flanagan S: The dopamine D ...
Tópico(s): Attention Deficit Hyperactivity Disorder
2006 - American Psychiatric Association | American Journal of Psychiatry
The cause of sudden infant death syndrome (SIDS) is unknown. Sleep-related impairment of respiratory control and arousal are postulated; hyperdopaminergic and hyposerotonergic dysfunction may contribute to events leading to infant apnea and SIDS. Psychosocial adversity and impulsive and compulsive behaviors characterize some families of SIDS victims. Tourette syndrome (TS) is a common hereditary neurobehavioral disorder characterized by the frequent presence of impulsive and compulsive behaviors. ...
Tópico(s): Infant Health and Development
1993 - Wiley | American Journal of Medical Genetics