Edward Lucie-Smith, Clement Crisp, Malcolm Brown, Caroline St John-Brooks Education Editor, John C Grant, John May (Governor), Barbara Hall, Richard Ellis, John Jay City Editor, Sir Thomas Bazley, Christopher Price Co-Chairman, Peter Fletcher, Anthony Clare, Rob Hughes, Stewart McCaffrey (Deputy Education Officer), Jonathan Miller, Eric Dymock, Stuart Bell MP, Jill Hartley, Christopher Smallwood Economics Editor, Danby Bloch, Askold Krusheinycky, Rachel Billington, Neville Hodgkinson Medical Correspondent, Graham Rose, Sally Emerson, John Stansell, Nicolette Jones, Alistair Scott, G E C Paton, Sally Payne, Ian Williams Business Correspondent, Stephen Milligan, Jason Tomas, J Smith, Mark Hosenball, Philip Dunn, Edward Welsh, Cal McCrystal, Barry Rogerson, Denise Winn, Caroline Baker, Jon Craig, Geordie Greig, Patrick Stoddart, Mario Modiano, Robert Sandall, Susan Marling, Alex Sutherland, Fleur de Villiers, David Brierley, Irwin Stelzer, Peter Godwin, Robert Hewison, Kate Etheridge's, Ivan Fallon, Mark Ottaway, David Dougill, Mick Brown, Joe Irving, R Blackburn, Cliff Temple, Betty Jackson, Tim O'Brien, Dr John Andrews, Maria Laura Avignolo, George Armstrong, Justine Picardie, Susan Crosland, David Cairns, Peter Kemp, Adrianne Blue, Norman Harris, Jeanette Winterson, Julia Neuberger, Lawrence James, George Perry, John Cassidy, Robin Marlar, Charlotte Atkins, Marion Devine, David Benson, Bernard Cafferty, Brian Moynahan, Marie Colvin Middle East Correspondent, Paul Donovan, Dag Pike, Jeff Randall, Jonathan Todd, Paul Driver, James Adams, Boris Schapiro, Andrea Dabrowski, Linda Allan Institution of Environmental Health Officers, Austin MacCurtain, David Leppard, Jon Futrell, Kaz Mochlinski, Jonas Savimbi, Brian Jackman, Tom Brook, Elizabeth Grice, John Hopkins, A Miles, Kerry Stephenson, Martin Jacques, Judi Bevan, Brian Walden, Peter Wilsher, M McMichael, Roanne Moore, Roger Wilsher, Diana Wright, Dr Catherine Feehan Senior Clinical Officer, Christopher Smallwood, Frederick Bowers, David Burk, Stephen Jones, Kenneth Branagh, N Wadham, Brian Deer, Richard Palmer, Raymond Godfrey, Frances Tattersfield, Mitchell Wheat, Bobby Turner, Rob Ryan, Keith Wheatley, Nigel Mansell, Beatrice Lacoste, Miranda Seymour, Brough Scott, Roy Towndrow, Louise Branson, Max Prangnell, Maurice Chittenden, Dudley Doust, Ray Mgadzah, Mick Brown's, Dr Robert Burchfield, David Hughes Political Correspondent, Brian MacArthur, Alan Tillier, Michael Jones Political Editor, Godfrey Smith, James Ferman Director, Richard Burnell, Sue Thomas, Brian Glanville, Angus Roxburgh, Lady Antonia Fraser, Edward Pearce, Simon Jenkins, Dillie Keane, Jon Craig Home Affairs Correspondent, Deirdre Fernand, Caroline Silver, Mrs H S Casimir, Gilbert Adair, Robert Erdmann, Ian Williams, John Cole, Marina Vaizey, Hugh Pearman, Tony Hetherington, Joanna Simon, Pauline Peters, Anthony Cox, Elisabeth Grice, James Adams Defence Correspondent, Muriel Bowen, John Brookes,
... Bank Centre Multiple Display Advertising Items British Midland T'pau Multiple Display Advertising Items Superwoman bites the dust ...
1988 - Gale Group | Sunday Times HA GDA
Gabriel de la Fuente, Mat誕s Reina, Orlando Mu撲z, Aurelio San Mart地, Jean-Pierre Girault,
From Schizanthus pinnatus Ruiz e t Pau.we have isolated seven new tropon-3a,60-dioZ diesters, schizanthines F 111, G (21, H 13j, I 141, K 181, ...
Tópico(s): Traditional and Medicinal Uses of Annonaceae
1988 - Elsevier BV | Heterocycles
Robert Philip, N C Phillips, John Huxley, Sam Dastor, John Wilkinson, Barbara Hall, Burton Anderson's, John Jay City Editor, John Davison, Graig Brown, Peter Gillman, C Varley, Rob Hughes, John Peter, Joyce Caruso, Mark Reason, Jeremy Laurance, Sarah Miller, Brian Deer Social Affairs Correspondent, Ian Burton, John Jay, Bill Martin Chief UK economist, Steve Balkam, Danby Bloch, Nick Rufford, Graham Rose, Judy Cooke, Sir Anthony Acland, Patrick Burns, Robin Morgan, Sally Payne, Robert Burchfield, Linda Taylor, James Johnson's, Marten Julian, Anna Ford, Jo Revill, Dalbert Hallenstein, Mark Hosenball, John Rowland, Jason Tomas, Carol Sarler, Edward Welsh, Cal McCrystal, Michael Rigby, Gerald Priestland, Dan Quayle, Caroline St John-Brooks, Jon Craig, E Marcov, Y Lein, Patrick Stoddart, Susan Marling, Kevin Mitchell, Alex Sutherland, Robert Sandall, Iain Johnstone, Terence Salter, Neville Hodgkinson, David Brierley, Pat Roberts, Irwin Stelzer, Keith Austin, E Jane Dickson, Peter Godwin, Robert Hewison, Ivan Fallon, David Dougill, Roz Kaveney, Dymphna Byrne, Peter H Lewis, Jane Bird, Joseph Giovannini, Maria Laura Avignolo, Susan Crosland, David Cairns, Stuart Lawson, Cairo, Geoff Whitten, Libby Purves, David Currie, Michael Jones, Diana Wright Personal Finance editor, Anne Moffat, Harry Hilditch, Pattie Barron, George Bush, E Mitchell Deputy Assistant Commissioner, George Perry, John Cassidy, Sue Mott, Catriona Robertson, Alwyn Wise, Iqbal Athas, Paul Bailey, Christine Toomey, Geoffrey Dicks, Brian Moynahan, Charles Brown, Bernard Cafferty, W J Burke, Simon Ragley, Paul Donovan, Janette Marshall, Amit Roy, Cloudia Roden's, Marsha Taylor, Jonathan Todd, Jeff Randall, Aidan Laverty, Paul Ableman, James Adams, Boris Schapiro, Alan Budd Chief economic adviser to Barclays Bank, Barrie Fairall, David Hughes, Austin MacCurtain, David Leppard, Tim Rayment, Mazher Mahmood, Gavyn Davies Chief UK economist, Marion Cotter, Kenneth Cork, Nicolas Freeling, LLoyd Bensten, Michael Dukakis, Elizabeth Grice, Tavleen Singh, Bryan Gould, David Lawrenson, John Hopkins, John Ferriday, Askold Krushelnycky, P. W. Goldberg, Mary Ensor, Judi Bevan, John Barnes, Brian Walden, Eric Marsden, Chlöe Colchester, Charles Allen, Gareth David, Brian Reading, Lloyd Bentsen, Stephen Pile, Malcolm Winton, Ivan Failon, Cheryl Taylor, Richard Cook, Marie Colvin, Craig Brown, Diana Wright, Angela Wilkes, Ali Ross, Stephen Jones, Desmond Shawe-Taylor, Brian Deer, Richard Palmer, Raymond Godfrey, Andrew Grice, Dr A a Mughram Al-Ghamdi Director General, Jeremy Lewis, Nick Rufford Science Correspondent, A Yampolsky, Roger Boyes, Miranda Seymour, Patrick Rowley, Stephen Davis, Colin McDowell, Dilys Powell, Ben Pimlott, Juan Williams, Bryan Appleyard, Andrew Hogg, Brough Scott, Alison Beckett, Tony Rocca, Richard Woods, Clive Everton, Caroline McGhie, Tony Osman, Peter Johnson, Barrie Penrose, Dudley Doust, Dr Vernon Coleman, John Thomas, Ian Dunning, Iola Smith, Robert Kiener, David Hughes Political Correspondent, Brian MacArthur, David Leitch, Michael Jones Political Editor, A Speizman, Steve Tongue, Bertice Reading, Richard Watson, Ronald Reagan, Sue Thomas, Paul Greengrass, Carole Sarler, Paul Tetley, Greg Hadfield Education Correspondent, Brian Clarke, Brian Glanville, Angus Roxburgh, Carmel McQuaid, Carrie Segrave, John Julius Norwich, Edward Pearce, Nicholas Barr, Anthony Holden, Peta Thornycroft, Simon Jenkins, Jon Craig Home Affairs Correspondent, Deirdre Fernand, Godfrey Golzen, Chris Bye Editor, David Sinclair, Jeanette Winterson's, Maureen Walker, David Wickers, T Forsyth, R Zelichenok, Ian Williams, Ellisabeth Bode, Michael Dukaki, Marina Vaizey, Lewis De Fries, Margaret Park, Rosemary Collins, Angela Long Innovation Editor, Jonathan Miller Media Editor, Dr Judith Pinnington, Tony James, Penny Perrick, Tony Hetherington, Maggie Drummond, Tony Elliott, Joanna Simon, Diana Dicken McLellan, I McCune, James Adams Defence Correspondent, Leslie Geddes-Brown, Georgina Howell,
... Multiple Classified Advertising Items Multiple Display Advertising Items T'pau The Spinners Farewell Christmas Tour Wembley Barbican Christmas ...
1988 - Gale Group | Sunday Times HA GDA
Alexander W. Schüttelkopf, J.A. Harrison, David H. Boxer, William N. Hunter,
... biosynthesis (10.Anderson L.A. McNairn E. Leubke T. Pau R.N. Boxer D.H. J. Bacteriol. 2000; ...
Tópico(s): Biochemical and Molecular Research
2002 - Elsevier BV | Journal of Biological Chemistry
Jonathan Northcroft, Waldemar Januszczak, John Dugdale, Hala Jaber, Barbara Hall, Doug Endersby, John Smith, David Barber, N J, Michelene Wandor, Jon Swain, Philip Norman, P Hutchinson, Sally Brock, Rob Hughes, John Peter, V S, Professor Gideon Garter, Chrissy Hey, William Lewis Business Editor, Amanda Ursell, Jonathan Miller, Jeane-Pierre Frankenhuis, Andrew Longmore, Kate Spicer, Katrina Mansion, Christopher Wood, Susan d'Arcy, J D, Peter Beaumont, Gareth Walsh, Frank Whitford, Ray Spiller, Ferdinand Mount, Anthony Lyman-Dixon, Kathryn Cooper, Susan Bell, William Lewis, P D, David Smith, Darren Campbell, Tim Richards, Dominic Utton, Paul Driver, Robert Sabdall, David Cracknell Political Editor, Michael Kilcommons, Neil Wormald, Sir Nigel Crisp Chief Executive, Richard Green, E P, Lynne Truss, Elizabeth Smith, Tony Allen-Mills, Simon Wilde, John O'Brien, Martin James, Ronald Trewartha, Anthony Sattin, Robert Winnett, Charles Nicholl, Tom English, Peter Wilson, Rosie Millard, Lawrence Dallaglio, Neil Wormaid, Rachel Dobson, Peter Wyman, David Dougill, Alan Bergson, Colln Brennan, Rod Wilkinson, Vinny Lee, Philippe Legrain chief economist, C Scully, Anna Bruning, Philip Kingsley, Thrasy Petropoulos, Dumeetha Luthra, Rob Maul, David Hewson, Patrick Campbell, Hugh Canning, Geraldine Hackett Education Correspondent, Nils Pratley, Jeremy Clarkson, Raymond Gubbay, Edward Porter, Peter Conradi, Victoria Segal, Hilary Clarke, Sarah Dempster, C Francis Warren Lancaster, Eben Black, John O'Donnell, K Browning, Shelley von Strunckel, Hugh McllVanney, Karthryn Cooper, Jeremy Guscott, John Sands Chairman of Pubmaster, Alicia Wyillie, Paula Robinson, David Walsh Chief Sports Writer, Annette Walker, L Goring, Roger Eglin, Paul Donovan, Tom Conran, Steve Waugh, Chris Woodhead, Madeleine Channer, Martin Spiro, Lucinda Kemeny, Jasper Gerard, Derek Clements, lrwin Stelzer, Michael Woodhead, John Humphrys, Michael Barrows, Nicholas Hellen, Murray Walker, Richard Brooks, Garth Pearce, David Leppard, Paul Durman, S Rodway, Mark Ludlow, Lisa Grainger, Alicia Wyllie, John Walker, John Mahoney, Mark Edwards, Sarah Gracie, David Pope, Susan Clark, Stephen Amidon, Matthew Sheahan, Zoë Brennan, Christina Lamb, Sean Newsom, Rehan Kularaine, Raymond Keene, William Chadwick, Gareth Huw Davies, David Cracknell, Stanley Stewart, Cosmo Landesman, Robbie Hudson, Jeff Tracy, Karina Mantavia, lan Hawkey, Andrea Maflin, Dr Gill Morgan, Stephen Jones, Dominic O'Connell, Stephen Bleach, Barry Flatman, Nick Cain, Michael Wright, Jenny Pitman, Daniel Dennett, Melinda Stevens, Natalie Graham, Kate Rew, M J, Caroline Donald, S D, Rob Ryan, Keith Wheatley, Jessica Brinton, David Walsh, Brian Ferguson, Jack Grimston, Colin McDowell, Bryan Appleyard, Stephen Armstrong, John Elliott, Colin McDowell's, Mark Anstead, Desmond Kilcoyne, Roger Frost, Bethan Cole, Sheherazade Goldsmith, Cox, Roland White, David Milburn, Maurice Chittenden, Scott Goodrick, Tom Naylor, Robert Mecall, Richard Brooks Arts Editor, Dr John Pitts, Bill Joel, Richard Rae, Mark Franchetti, Ray Hutton, Claudia Croft, Jon Ungoed-Thomas, Alexandra Dawe, Orazio Gualtieri, Naomi Wolf, Michael Sheridan, Deborah Scroggins, Simon Potter, John Harlow, Peter Clarke, Michael Austin, Dipesh Gadher, John Waples, Mike Slay, A A Gill, Ros Dodd, Brian Glanville, Louise Johncox, John Carey, Enda Leahy, Tom Robbins, Mary Braid, Nick Fielding, Lewis Stuart, Jason Mellor, Lauren St John, Jonathan Calvert, Jonathan Leake Science Editor, T L, Ken Yankey, Peter Walker, Long Nails, Justin Sparks, Sally Kinnes, Maria McErlane, Naomi Caine, Nigel Powell, Jeff Lampert Competitive Business Banking Analysis, Hugh McilVanney, David Wickers, Roger Dobson, Brian Doogan, Minette Marrin, John Cornwell, Mark Hodson, Andrew Frankel, Graham Norwood, Joe Lovejoy, Jonathan Futrell, P Coates, Rupert Steiner, M Norwell, David Budworth, T Cawley, Dan Cairns, Paul Stephen Lubicz, Steve Henley, Allica Wyllie, Hugh Pearman, Robert Kagan, David Smith Economics Editor, Marianne Bartram, Sarah Baxter, Patricia Cleveland-Peck, Ruth Bull, Helen Vandevelde, Chris Feetenby, Vernon Coleman, Gerald Kennedy, Professor Carof Black, Matthew Goodman, India Knight, Simon Howard, John Sanderson, Danny Danziger, Mary Dunkin, Jason Dawe, Sabi Phagura, Dominic Rushe, Sian Griffiths, Mansieur Mangetout, Felix Dennis,
... rat pack Time and place Carol Decker wrote T'Pau's hits in a chilly attic in Shrewsbury, ...
2003 - Gale Group | Sunday Times HA GDA
Andrew P. Makrigiannis, Amanda T. Pau, Pamela L Schwartzberg, Daniel W. McVicar, Thomas W. Beck, Stephen K. Anderson,
The murine Ly49 gene family is functionally analogous to the human killer cell Ig-like receptor (KIR) family of class I major histocompatibility complex (MHC) receptors. The number of KIR genes varies dramatically between individuals; however, the organization of the Ly49 genes has only been determined for the C57BL/6 (B6) mouse. The organization of the 129 Ly49 loci was determined from a BAC contig map by PCR and Southern blot analysis. In addition to the 10 Ly49 genes known from previous studies ...
Tópico(s): IL-33, ST2, and ILC Pathways
2002 - Elsevier BV | Genomics
H. B. Dehgani-Tafti, David Wade, Frances Gibb, Legal Affairs Correspondent, Clifford Longley, DJM, Holly Hill, Daniel Ward, Motor Industry Correspondent, Simon O'Hagan, Executive Editor Kenneth Fleet, Hazhir Teimourian, Mark Cliffe and Neil MacKinnon, Gordon Allan, Iain Macleod, Edgar Gordon, Philip Howard, Richard Ford and Nicholas Wood, Ian Murray, Michael Binyon, Jeremy Kingston, Roy Moor, Richard Evans, Media Editor, Carol Leonard, S. E. Scammell, Roger Jones, Nicholas Wood and Jill Sherman, Stuart Jones Football Correspondent, John Clare, Education Correspondent, Mario Modiano, Michael McCarthy, Colin Narbrough, John Spicer, Employment Affairs Correspondent, Gerald Davies, John Newell, Bernard Levin, Gerry Harrison, Bryan Stiles, Allan Massie, Peter Davenport, Ruth Gledhill, Rodney Cowton, Transport Correspondent, John Woodcock Cricket Correspondent, Peter Waymark, David Smith Economics Correspondent, Ronald Faux, Employment Affairs Correspondent, David Hands, Enoch Powell, John Walley, Anne Whitehouse, Ian Bruce, Gavin Bell, Rex Bellamy Tennis Correspondent, Paul Vallely, Ronald Faux Employment Affairs Correspondent, Richard Dauncey, Sydney Friskin, Nicholas Harling, John Carr (Chairman), Dennis Signy, David Miller, Robin Oakley Political Editor, Chris Thau, Brian Martin, Jill Sherman, Social Services Correspondent and Charles Bremner, William Holmes, Alison Eadie, Peter Davalle, Dennis Shaw, Lynda Murdin, Arts Correspondent, John Russell Taylor, Barbara Amiel, Steve Acteson, Andrew McEwen, Diplomatic Correspondent, John A. Hill, Peter Bryan, Robert Matthews, Cathy Harris, Richard Owen, Richard Evans Media Editor, David Young, Energy Correspondent, Joyce Whitehead, Maxwell Newton, Humphrey Hawkesley, Richard Bassett, Sheila Gunn Political Staff, David Hands Rugby Correspondent, Kenneth Fleet, Julian Clauson, Christopher Walker, Carol Ferguson, Edward Townsend, Industrial Correspondent, Clive White, Paul Newman, Sarah Jane Checkland Art Market Correspondent, Alan Franks, Michael Hornsby, Michael Seely, Sarah Jane Checkland, Jack Dominian, Ian Stafford, David Sinclair, Tim Jones, Peter Tarrant-Willis, John Woodcock, Cricket Correspondent, Robert Matthews and David Watts, Bailey Morris, Keith Macklin, Vince Wright, Susan MacDonald, Chris Than, Harvey Elliott Air Correspondent, Penny Perrick, Jimmy Hill, Maggie Drummond, Philip Jacobson, Rodney Lord Economics Editor, Peter Evans, Home Affairs Correspondent, David Walker, Public Administration Correspondent, Richard Coppin, Robert Lorge,
... invention Radio Helena International High quality bubblegum Rock T'Pau HAmmersmith Oden Home truths for home managers Women ...
1987 - Gale Group | TDA
Alice S Chen-Plotkin, Kaipo T. Pau, Jeremy D. Schmahmann,
Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) ...
Tópico(s): Parkinson's Disease Mechanisms and Treatments
2008 - American Medical Association | Archives of Neurology
Victor P.T. Pau, Karin Abarca-Heidemann, Brad S. Rothberg,
MthK is a Ca(2+)-gated K(+) channel whose activity is inhibited by cytoplasmic H(+). To determine possible mechanisms underlying the channel's proton sensitivity and the relation between H(+) inhibition and Ca(2+)-dependent gating, we recorded current through MthK channels incorporated into planar lipid bilayers. Each bilayer recording was obtained at up to six different [Ca(2+)] (ranging from nominally 0 to 30 mM) at a given [H(+)], in which the solutions bathing the cytoplasmic side of the channels ...
Tópico(s): Cardiac electrophysiology and arrhythmias
2010 - Rockefeller University Press | The Journal of General Physiology
Victor P.T. Pau, Yongfang Zhu, Zhiguang Yuchi, Quyen Q. Hoang, Daniel S.C. Yang,
KcsA, a potassium channel from Streptomyces lividans, is a good model for probing the general working mechanism of potassium channels. To date, the physiological activator of KcsA is still unknown, but in vitro studies showed that it could be opened by lowering the pH of the cytoplasmic compartment to 4. The C-terminal domain (CTD, residues 112-160) was proposed to be the modulator for this pH-responsive event. Here, we support this proposal by examining the pH profiles of: (a) thermal stability of ...
Tópico(s): Plant-based Medicinal Research
2007 - Elsevier BV | Journal of Biological Chemistry
Victor P.T. Pau, Frank J. Smith, A.B. Taylor, Liubov Parfenova, Elsie Samakai, Matthew M. Callaghan, Karin Abarca-Heidemann, P. John Hart, Brad S. Rothberg,
Regulator of K + conductance (RCK) domains control the activity of a variety of K + transporters and channels, including the human large conductance Ca 2+ -activated K + channel that is important for blood pressure regulation and control of neuronal firing, and MthK, a prokaryotic Ca 2+ -gated K + channel that has yielded structural insight toward mechanisms of RCK domain-controlled channel gating. In MthK, a gating ring of eight RCK domains regulates channel activation by Ca 2+ . Here, using electrophysiology ...
Tópico(s): Neuroscience and Neuropharmacology Research
2011 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Hiroyuki Morimoto, Tetsu Tsubogo, Nichole D. Litvinas, John F. Hartwig,
... 6205– 6213. 22A. Annunziata, C. Galli, M. Marinelli, T. Pau, Eur. J. Org. Chem. 2001, 1323– 1329. 23A. ...
Tópico(s): Catalytic Cross-Coupling Reactions
2011 - Wiley | Angewandte Chemie International Edition
Frank J. Smith, Victor P.T. Pau, Gino Cingolani, Brad S. Rothberg,
RCK domains control activity of a variety of K+ channels and transporters through binding of cytoplasmic ligands. To gain insight toward mechanisms of RCK domain activation, we solved the structure of the RCK domain from the Ca2+-gated K+ channel, MthK, bound with Ba2+, at 3.1 Å resolution. The Ba2+-bound RCK domain was assembled as an octameric gating ring, as observed in structures of the full-length MthK channel, and shows Ba2+ bound at several positions. One of the Ba2+ sites, termed C1, overlaps ...
Tópico(s): Neuroscience and Neuropharmacology Research
2012 - Elsevier BV | Structure
Frank J. Smith, Victor P.T. Pau, Gino Cingolani, Brad S. Rothberg,
Ligand binding sites within proteins can interact by allosteric mechanisms to modulate binding affinities and control protein function. Here we present crystal structures of the regulator of K+ conductance (RCK) domain from a K+ channel, MthK, which reveal the structural basis of allosteric coupling between two Ca2+ regulatory sites within the domain. Comparison of RCK domain crystal structures in a range of conformations and with different numbers of regulatory Ca2+ ions bound, combined with complementary ...
Tópico(s): Neuroscience and Neuropharmacology Research
2013 - Nature Portfolio | Nature Communications
Andrew P. Makrigiannis, Amanda T. Pau, Ali Saleh, Robin Winkler-Pickett, John R. Ortaldo, Stephen K. Anderson,
Abstract The Ly49 family of NK cell receptors and its MHC-binding characteristics have only been well characterized in C57BL/6 (B6) mice. Previous studies have shown that 129/J mice express unique Ly49 genes that are not found in the B6 strain. Screening of a 129/J cDNA library led to the discovery of 10 distinct full-length Ly49-related coding sequences (Ly49e, g, i, o, p, r, s, t, u, and v). Although 129/J mice share identical class I MHC (Kb and Db) transcripts with B6 mice, only one Ly49 is identical ...
Tópico(s): CAR-T cell therapy research
2001 - American Association of Immunologists | The Journal of Immunology
David G. Gourley, Alexander W. Schüttelkopf, Lisa A. Anderson, Nicholas C. Price, David H. Boxer, William N. Hunter,
... of molybdopterin (15Anderson L.A. McNairn E. Leubke T. Pau R.N. Boxer D.H. J. Bacteriol. 2000; ...
Tópico(s): Amino Acid Enzymes and Metabolism
2001 - Elsevier BV | Journal of Biological Chemistry
Gary S. Coombs, Robert C. Bergstrom, Edwin L. Madison, David R. Corey,
... peptidesInserted sequence (P4,P3,P2,P1↓P1′,P2′)t-PAu-PAkcatKmkcat/KmkcatKmkcat/Kms−1μmm−1s−1s−1μmm−1s− ...
Tópico(s): Peptidase Inhibition and Analysis
1998 - Elsevier BV | Journal of Biological Chemistry
Victor P.T. Pau, Yufeng Zhou, Yajamana Ramu, Yanping Xu, Zhe Lü,
Tópico(s): Cardiac electrophysiology and arrhythmias
2017 - Nature Portfolio | Nature Structural & Molecular Biology
Chetan K. Chana, Pierre Maisonneuve, Ganna Posternak, Nicolas G.A. Grinberg, Juline Poirson, Samara Mishelle Ona, Derek F. Ceccarelli, P. Mäder, Daniel J. St‐Cyr, Victor P.T. Pau, Igor Kurinov, Xiaojing Tang, Dongjing Deng, Weiren Cui, Wenji Su, Letian Kuai, Richard Söll, Mike Tyers, Hannes Röst, Robert A. Batey, Mikko Taipale, Anne‐Claude Gingras, Frank Sicheri,
Targeted protein degradation (TPD) strategies exploit bivalent small molecules to bridge substrate proteins to an E3 ubiquitin ligase to induce substrate degradation. Few E3s have been explored as degradation effectors due to a dearth of E3-binding small molecules. We show that genetically induced recruitment to the GID4 subunit of the CTLH E3 complex induces protein degradation. An NMR-based fragment screen followed by structure-guided analog elaboration identified two binders of GID4, 16 and 67, ...
Tópico(s): Peptidase Inhibition and Analysis
2022 - American Chemical Society | Journal of Medicinal Chemistry
Monica Bubenik, P. Mäder, Philippe Mochirian, Frédéric Vallée, Jillian M.R. Clark, Jean‐François Truchon, Alexander L. Perryman, Victor P.T. Pau, Igor Kurinov, Karl E. Zahn, Marie-Ève Leclaire, Robert Papp, Marie‐Claude Mathieu, Martine Hamel, Nicole M. Duffy, Claude Godbout, Matias Casás‐Selves, Jean‐Pierre Falgueyret, Prasamit S. Baruah, Olivier Nicolas, Rino Stocco, Hugo Poirier, Giovanni De Martino, Alexanne Bonneau Fortin, Anne Roulston, Amandine Chefson, Stéphane Dorich, Miguel St‐Onge, Purvish P. Patel, Charles Pellerin, Stéphane Ciblat, Thomas Pinter, Francis Barabé, Majida El Bakkouri, Paranjay Parikh, Christian Gervais, Agnel Sfeir, Yaël Mamane, Stephen J. Morris, W. Cameron Black, Frank Sicheri, Michel Gallant,
DNA polymerase theta (Polθ) is an attractive synthetic lethal target for drug discovery, predicted to be efficacious against breast and ovarian cancers harboring BRCA-mutant alleles. Here, we describe our hit-to-lead efforts in search of a selective inhibitor of human Polθ (encoded by POLQ). A high-throughput screening campaign of 350,000 compounds identified an 11 micromolar hit, giving rise to the N2-substituted fused pyrazolo series, which was validated by biophysical methods. Structure-based drug ...
Tópico(s): DNA and Nucleic Acid Chemistry
2022 - American Chemical Society | Journal of Medicinal Chemistry
Janek Szychowski, Robert Papp, Evelyne Dietrich, Bingcan Liu, Frédéric Vallée, Marie-Ève Leclaire, Jimmy Fourtounis, Giovanni Martino, Alexander L. Perryman, Victor P.T. Pau, Shou Yun Yin, P. Mäder, Anne Roulston, Jean‐François Truchon, C. Gary Marshall, Mohamed Lamine Diallo, Nicole M. Duffy, Rino Stocco, Claude Godbout, Alexanne Bonneau-Fortin, Rosie Kryczka, Vivek Bhaskaran, Daniel Y.L. Mao, Stephen Orlicky, Patrick Beaulieu, Pascal Turcotte, Igor Kurinov, Frank Sicheri, Yaël Mamane, Michel Gallant, W. Cameron Black,
PKMYT1 is a regulator of CDK1 phosphorylation and is a compelling therapeutic target for the treatment of certain types of DNA damage response cancers due to its established synthetic lethal relationship with CCNE1 amplification. To date, no selective inhibitors have been reported for this kinase that would allow for investigation of the pharmacological role of PKMYT1. To address this need compound 1 was identified as a weak PKMYT1 inhibitor. Introduction of a dimethylphenol increased potency on ...
Tópico(s): Cancer therapeutics and mechanisms
2022 - American Chemical Society | Journal of Medicinal Chemistry
Konstantinos Kavallieratos, Alberto Sabucedo, Amanda T. Pau, Johanna M. Rodriguez,
As part of a mass spectrometric investigation of the binding properties of sulfonamide anion receptors, an atmospheric pressure chemical ionization mass spectrometric (APCI-MS) method involving direct infusion followed by thermal desorption was employed for identification of anionic supramolecular complexes in dichloromethane (CH2Cl2). Specifically, the dansylamide derivative of tris(2-aminoethyl)amine (tren) (1), the chiral 1,3-benzenesulfonamide derivatives of (1R,2S)-(+)-cis-1-amino-2-indanol (2), ...
Tópico(s): Molecular Sensors and Ion Detection
2005 - American Chemical Society | Journal of the American Society for Mass Spectrometry
Antonella Bugatti, Francesca Caccuri, Federica Filippini, Cosetta Ravelli, Arnaldo Caruso,
... F. Sherman B.T. Rehm C.A. Imamichi T. Pau A. Catalfamo M. Fauci A.S. Lane H. ...
Tópico(s): Viral-associated cancers and disorders
2021 - Elsevier BV | Journal of Biological Chemistry
Zhiguang Yuchi, Victor P.T. Pau, Bridget X. Lu, M.S. Junop, Daniel S.C. Yang,
KcsA, a potassium channel from Streptomyces lividans, was the first ion channel to have its transmembrane domain structure determined by crystallography. Previously we have shown that its C-terminal cytoplasmic domain is crucial for the thermostability and the expression of the channel. Expression was almost abolished in its absence, but could be rescued by the presence of an artificial left-handed coiled coil tetramerization domain GCN4. In this study, we noticed that the handedness of GCN4 is ...
Tópico(s): Mass Spectrometry Techniques and Applications
2009 - Wiley | FEBS Journal
Zhiguang Yuchi, Victor P.T. Pau, Daniel S.C. Yang,
The prokaryotic potassium channel from Streptomyces lividans, KcsA, is the first channel that has a known crystal structure of the transmembrane domain. The crystal structure of its soluble C-terminal domain, however, still remains elusive. Biophysical and electrophysiological studies have previously implicated the essential roles of the C-terminal domain in pH sensing and in vivo channel assembly. We examined this functional assignment by replacing the C-terminal domain with an artificial tetramerization ...
Tópico(s): Electrochemical Analysis and Applications
2008 - Wiley | FEBS Journal
Heather Bruce, A.U. Singer, E.V. Filippova, Levi L. Blazer, Jarrett Adams, Leonie Enderle, Moshe Ben‐David, Elizabeth Radley, Daniel Y.L. Mao, Victor P.T. Pau, Stephen Orlicky, Frank Sicheri, Igor Kurinov, S. Atwell, Anthony A. Kossiakoff, Sachdev S. Sidhu,
The atomic-resolution structural information that X-ray crystallography can provide on the binding interface between a Fab and its cognate antigen is highly valuable for understanding the mechanism of interaction. However, many Fab:antigen complexes are recalcitrant to crystallization, making the endeavor a considerable effort with no guarantee of success. Consequently, there have been significant steps taken to increase the likelihood of Fab:antigen complex crystallization by altering the Fab framework. ...
Tópico(s): Protein Structure and Dynamics
2023 - Wiley | Protein Science
... and energy intake. Appetite 48, 167– 175 Just T, Pau HW, Engel U, Hummel T, 2008. Cephalic phase ...
Tópico(s): Sensory Analysis and Statistical Methods
2010 - European Food Safety Authority | EFSA Supporting Publications
Daniel Stapor, Anil Rengan, Mark G. Weiner, Huaqing Zhao, Nadia Ali,
... data for this study was drawn from the T'PAU (Temple Population Access Utility) research data warehouse that ...
Tópico(s): Intramuscular injections and effects
2018 - Elsevier BV | Blood
Zhiguang Yuchi, Victor P.T. Pau, Daniel S.C. Yang,
KcsA, a prokaryotic potassium channel, is the first channel that has a known crystal structure of the transmembrane domain. The crystal structure of its soluble C-terminal domain, however, still remains elusive. Biophysical and electrophysiological studies have previously implicated the essential roles of the C-terminal domain in pH sensing and in vivo channel assembly. We examined this functional assignment by replacing the C-terminal domain with an artificial tetramerization domain, GCN4-LI. The ...
Tópico(s): Analytical Chemistry and Sensors
2009 - Elsevier BV | Biophysical Journal
Victor P.T. Pau, Karin Abarca-Heidemann, Brad S. Rothberg,
MthK is a Ca2+-gated K+ channel whose activity is modulated by cytoplasmic pH. To determine possible mechanisms underlying the channel's pH sensitivity, we recorded current through MthK channels, which were purified from E.coli membranes, reconstituted into liposomes and then incorporated into planar lipid bilayers. Each bilayer recording was obtained at up to six different [Ca2+] (ranging from nominally 0 to 30 mM) at a given pH, in which the solution bathing the cytoplasmic side of the channels ...
Tópico(s): Neuroscience and Neuropharmacology Research
2010 - Elsevier BV | Biophysical Journal