Yuan Xie, Liqun He, Yanyu Zhang, Hua Huang, Fan Yang, Min Chao, Haiyan Cao, Jianhao Wang, Yaling Li, Lingxue Zhang, Lele Xin, Bing Xiao, Xinxin Shi, Xue Zhang, Jiefu Tang, Lene Uhrbom, Anna Dimberg, Liang Wang, Lei Zhang,
... for GBM treatment is urgently needed. Methods Temozolomide (TMZ) delivery was investigated in CT2A and PDGFB-driven RCAS/tv-a orthotopic glioma models. Transcriptome analysis was performed on ECs from murine gliomas. Mfsd2a deficient, Cav1 deficient, and Mfsd2a EC-specific inducible mice were developed to study the underlying molecular mechanisms. Results We demonstrated that inhibiting Wnt signaling by LGK974 could increase TMZ delivery and sensitize glioma to chemotherapy in both ...
Tópico(s): MicroRNA in disease regulation
2023 - Oxford University Press | Neuro-Oncology
Montserrat Puigdelloses-Vallcorba, Alice Buonfiglioli, Gonzalo Piñero, Zhi Hong Chen, Dolores Hambardzumyan,
... of Msh2 in GBM growth and resistance to TMZ and immunotherapy. We have generated tumors with reduced or abrogated Msh2 using GEMMs based on the RCAS/tv-a gene transfer system in combination with mice ...
Tópico(s): Glioma Diagnosis and Treatment
2023 - Oxford University Press | Neuro-Oncology
Yael Mardor, David Guez, David Last, Dianne Daniels, Yuval Grober, Ouzi Nissim, Chen Hoffmann, Dvora Nass, Alisa Talianski, Roberto Spiegelmann, Zvi R. Cohen, Leor Zach,
... TEs and stable TVs consistent with pseudoprogression. Adjuvant TMZ was continued followed by decreased lesion volumes. 2 patients (GBM/AA) showed increased TVs 5 months/years post chemoRT and were referred to Avastin/surgery. One patient was scanned 2 wks post chemoRT with clinical deterioration and rescanned 3 wks later when stabilized showing significantly increased TVs with no change on standard MRI. The patient was re-operated. Brain ...
Tópico(s): MRI in cancer diagnosis
2013 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
Montserrat Puigdelloses Vallcorba, Gonzalo Piñero, Dolores Hambardzumyan,
... of Msh6 in GBM growth and resistance to TMZ and immunotherapy, we have generated immunocompetent genetically engineered mouse models (GEMMs) of GBM with germline loss of Msh6. To generate tumors with reduced or abrogated Msh6, we utilized GEMMs based on the RCAS/tv-a gene transfer system in combination with mice ...
Tópico(s): Cancer Cells and Metastasis
2022 - Oxford University Press | Neuro-Oncology
Montserrat Puigdelloses Vallcorba, Alice Buonfiglioli, Gonzalo Piñero, Zhihong Chen, Dolores Hambardzumyan,
... of Msh2 in GBM growth and resistance to TMZ and immunotherapy, we have generated immunocompetent genetically engineered mouse models (GEMMs) of GBM with germline or somatic loss of Msh2. To generate tumors with reduced or abrogated Msh2, we utilized GEMMs based on the RCAS/tv-a gene transfer system in combination with mice ...
Tópico(s): Cancer Genomics and Diagnostics
2022 - American Association for Cancer Research | Cancer Research
Michael Lundemann, Junia C. Costa, Ian Law, Silke Engelholm,
... to the CTV plus concurrent and adjuvant temozolomide (TMZ). Treatment failure volume (TFV) was defined as the earliest radiological evidence of residual or recurrent disease on post-therapeutic MRI. The maximum distances from GTV-MR and GTV-MRPET to encompass TFV, and the sensitivity as well as specificity between TV and TFV, were calculated and pairwise compared (Wilcoxon). ...
Tópico(s): Medical Imaging Techniques and Applications
2014 - Oxford University Press | Neuro-Oncology
... News 23 Aug. 2010. Web. 4 Jan. 2011. TMZ Staff. “The Situation's Rap Song—Listen at Your Own Risk.” TMZ 14 June 2010. Web. 4 Jan. 2011. US ...
Tópico(s): Critical Theory and Philosophy
2014 - Wiley | The Journal of Popular Culture
М. Г. Глезер, В. А. Выгодин, E. L. Nekrasova, И. А. Хлопина, K. S. Nubret, Ye.A. Agafonova, S. P. Ternavsky, O. V. Bardukova, N. M. Kutyakova, Y. V. Berestennikova, V. V. Ustyugova, Т. А. Филатова, И Г Халтурина, К. А. Ищенко, O. A. Karutskaja, V. I. Panikar, О. А. Болховитина, E. I. Bondarev, Iu N Eremin, S. I. Kadashova, O. M. Frolova, Iryna Petukhova, А. В. Суворов, Y. V. Zhuchkova, M. A. Kuhl, Л. В. Родионова, T. P. Musurok, I. A. Ivkova, Alexander Ermakov, E. M. Stukalova, V. N. Chumakov, E. Y. Rubezhanskaja, A. A. Kotlova, Anna Pushkareva, L. V. Dmitrieva, E. V. Belkina, О Э Соловьева, S. L. Panyulaytenene, O. G. Sarkisyan, G. V. Konovalova, S.S. Kuznetsova, С.В. Николаева, I. V. Trubitsyna, О. А. Алексеева, M. E. Kozmina, N. A. Babautseva, I. V. Kochetkova, А. А. Анохин, E.V. Vovk, A. N. Buyko, E. S. Malahatka, Maša Iskra, S. N. Shilonosov, G. V. Moiseenko, Y. S. Tomm, N. A. Stopyatuk, E. G. Grigorieva, A. A. Zaitseva, Natalia A. Zaitseva, I. A. Sirotkina, R. L. Kiyanichenko, S. P. Grigoriev, N. V. Medvedeva, M. Y. Svatkov, Л. В. Голубева, Lyudmila Kozhevnikova, A. A. Chernova, A. Y. Dolbilkin, A. Y. Palvinskaya, Т. В. Баранова, T. S. Habeeva, D. A. Khodus, G. N. Ermolaeva, I. V. Arbatskaja, V. R. Idiatullina, M. E. Egorova, И. Р. Галимова, M. V. Kuklina, A. A. Mamatadzhiev, R. N. Rahmatullina, Z. F. Kim, V. S. Stepanova, I. E. Gerr, G. I. Levchenko, S. E. Dubinkina, R. A. Zoob, O. N. Krokhmal, S. V. Lisina, N. G. Kudryavtseva, D. V. Sitnikov, D. G. Lunegov, N. A. Evdokimova, Ю. В. Иванова, A. V. Manilova, O. L. Bessergeneva, E. E. Mokhova, Olena Kulchytska, O. V. Shulikina, V. G. Ananenko, O. T. Ivanova, M. D. Alentyeva, M. E. Didur, K. A. Zemzyulina, N. P. Kartina, Ю. А. Капустина, N. N. Skurikhina, G. I. Novoselova, T. A. Gracheva, I. V. Shiryaev, O. V. Avdeeva, О. С. Федорова, E. A. Filatkina, N. V. Pankova, А. В. Михайлова, Т. В. Самойленко, N. V. Zhurkina, Ekaterina Riazantseva, L. V. Mokrousova, A. Z. Kulieva, T. N. Rychkova, T. A. Skripka, S. Y. Krasnevich, L. F. Fedorova, S. A. Abdalova, M. S. Tremaskina, Z. N. Mushaeva, T Sládková, P. S. Gabisova, T. V. Kononova, Vlada V. Maslova, Anna Kazakova, E. O. Khamitsaeva, O. S. Ratnikova, N. A. Ivanova, Е.В. Савельева, I. V. Obikhodova, G. I. Puakseva, Andrei Gunin, I. Y. Skvortsova, I. I. Chugunova, N. A. Shestopalova, O. A. Kutina, Y. V. Ponomareva, T. P. Nikolina, С. И. Соколова, T. N. Fastovshchuk, L. I. Pak, A. S. Kazaryan, O. V. Sabitova, Kuznetsova Tv, Z. K. Kudzaeva, A. A. Pomiluyko, Alexander V. Kudryavtsev, T. M. Gabaraeva, Е. А. Титова, E. A. Levtsova, N. I. Faiman, V. V. Chernomorets, O. A. Evseeva, N. S. Lopata, Л. А. Лобанкова, О. В. Комарова, E. M. Tsybulnikova, Oliver Kutz, O. S. Kalimeeva, I. G. Nudikova, M. V. Chibrikina, K. A. Sarkisova, R. V. Kalakova, N. V. Erezeeva, G. S. Shirganova, A. A. Chmil, M. S. Kafanova, С. В. Ермолаева, R. A. Koshrokova, G. M. Orozalieva, E. S. Barnashova, Ш. В. Ахадов, E. V. Podmoskova, А. Б. Борисова, E. V. Chirkunova, Tatiana A. Chernova, Nikola Kosová, O. V. Guseva, S. A. Kuzovkova, I. V. Mulin, О. В. Ларіна, S. V. Mingaleva, L. A. Tsvetkova, I. K. Vysotskaja, T. Y. Degtereva, L. I. Reshetova, I. I. Koblyakova, A. N. Chigisova, L. A. Krivenko, М. А. Матвеева, L. A. Kozlova, O. O. Yakhontova, G. R. Musina, E. A. Kuznetsova, V. I. Adamov, S. P. Podolnaya, A. V. Mukhin, I. A. Giley, N. M. Savelyeva, А. В. Новикова, Y. N. Makhonina, T. S. Shemetova, Л. В. Тарасова, I. V. Galushko, L. I. Nasakina, M. I. Chaadaeva, О. А. Гречишкина, G. A. Hamrina, O. V. Oshchepkova, S. D. Senina, Erika Graf, Iryna Kozhevnikova, S. F. Lukina, E. V. Vinokurova, A. T. Sobol, N. K. Nevolina, O. T. Zdankovich, Z. N. Luzhnova, А. A. Мамедова, V. A. Osipova, V. L. Zheltova, L. N. Shahramanyan, E. D. Bulygina, N. N. Panchenko, T. P. Tolstokoneva, G. V. Batalo, M. K. Mazrukho, С. А. Чепурненко, N. I. Alexandrova, Natalia Starostina, I. S. Grushetskaya, O. Y. Novikova, Е. А. Крылова, L. V. Arhipova, S. V. Kostomarova, Oksana Khudyakova, M. A. Nasyrova, N. N. Yakimova, G. V. Kositsyna, E. A. Ovchinnikova, E. I. Ryazanova, V. P. Kuzmin, A. D. Basharin, L. V. Bulycheva, A. R. Soesheva, G. R. Timaeva, N. K. Burenina, Nikolai Nikolov, I. V. Udaltsova, Z. M. Zhenihova, E. S. Pukhova, E. A. Shmeleva, A. I. Luchko, A. M. Ermolenko, E. Y. Melekhova, Y. V. Kadyseva, E. V. Nechvolod, E. M. Al-Atar, E. J. Sereda, N. A. Grigorieva, V. G. Algina, A. E. Borisov, Z. S. Sabolova, A. Y. Novozhenina, L. A. Silantyeva, N. N. Litsis, N. V. Gamayunova, E. E. Velikanova, N. Y. Gulyaeva, О. А. Журавлева, E. G. Chichvarina, Е. Г. Калинина, O. S. Bidzhieva, N. V. Vasilievа, N. V. Novokreschenova, G. R. Osmanova, S. L. Lugovtsova, E. N. Gadomskaya, E. A. Pastukhova, L. V. Krapivina, Irina Kireeva, E. E. B. Mironova, O. G. Nikiforova, A. E. Vorfolomeeva, E. I. Orekhova, O. K. Evdokimova, Е. А. Наумова, A. V. Shtets, M. V. Novikova, L. F. Moiseeva,
Trimetazidine (TMZ) was shown to reduce angina symptoms and increase the exercise capacity in stable angina (SA) patients. A ... antianginal medications, and overall efficacy and tolerability of TMZ 80 mg od were assessed in a real- ... age 62.8, 48% male). After 3 months, TMZ 80 mg od treatment led to a significant ( ... 0.0001) at month 3. Patient satisfaction with TMZ od was 9.5 [on a scale of ... at month 3. In this prospective, observational study, TMZ 80 mg od effectively reduced angina attacks and ...
Adis, Springer Healthcare
H. Elhalawani, T Lin, Karine A. Al Feghali, S. Radwan, Neil Chevli, Abdallah Mohamed, Clifton D. Fuller, C. Chung,
... GBM) failures following concurrent chemoradiation (CRT) and temozolomide (TMZ) as either marginal or in-field. This study ... documented recurrence following treated with post-operative definitive TMZ and RT with IMRT for biopsy-proven GBM ... planned dose and spatially to the target volumes (TV). Failures types were classified based on: (1) location of centroid relative to the initial TV, where central = centroid within TV and peripheral = centroid outside TV and (2) dosimetry based on dose to 95 % ... dose = fD95% is >95 % dose prescribed to initial TV) and low-dose = fD95% is <95% dose prescribed ...
Tópico(s): Medical Imaging Techniques and Applications
2018 - Elsevier BV | International Journal of Radiation Oncology*Biology*Physics