Xavier Fonrose, Fréderic Ausseil, Emmanuelle Soleilhac, Véronique Masson, Bruno David, Isabelle Pouny, Jean‐Christophe Cintrat, B. Rousseau, Caroline Barette, Georges Massiot, Laurence Lafanéchère,
... TCP) and its readdition by tubulin tyrosine ligase (TTL). We and others have previously shown that suppression of TTL and resulting accumulation of detyrosinated tubulin are frequent ... of poor prognosis. Explanations for the involvement of TTL and detyrosinated tubulin in tumor progression arise from ...
Tópico(s): Microbial Natural Products and Biosynthesis
2007 - American Association for Cancer Research | Cancer Research
Raquel Tur, J. Parra, Robert C. Martin, JE Alés-Martínez,
Abstract BACKGROUND The study of sentinel lymph nodes (SLN) assessed by One Step Nucleic Acid Amplification (OSNA, Sysmex, Kobe, Japan) creates a new variable, Total Tumor Load (TTL). This variable is defined as the total number of CK19 mRNA copies in all positive SLN (copies/microL). The latest edition of the Spanish Oncological Gynecology Society (SEGO) Guideline (2017) proposes complete axillary lymph node dissection (ALND) when TTL is 15,000 copies or more in early breast cancer. In our center we are ...
Tópico(s): Breast Cancer Treatment Studies
2019 - American Association for Cancer Research | Cancer Research
So C. Wong, Anthony L. Nicholas, Jeff Carlson, Dongxu Shu, Che Liu, Rui Chu, Amanda Frankiewicz, Holly Hamilton, Casi M. Schienebeck, Aaron Andersen, Matthew Fowler-Watters, Stephanie Bertin, Xiaokai Li, Bo Chen, Josh Schumacher, Julia Hegge, Bruce D. Given, Zhen Li,
... RNAi with PK enhancement and tumor targeting ligand (TTL) is required. Optimization of the HIF2 RNAi construct ...
Tópico(s): RNA Research and Splicing
2019 - American Association for Cancer Research | Cancer Research
Martín Espinosa-Bravo, F. Pérez-Ceresuela, Sebastian Díaz-Botero, Vicente Peg, Isabel T. Rubio,
Abstract Background: Total tumoral load (TTL) in the sentinel lymph nodes (SLN) assessed by the OSNA assay is a new variable that is able to predict the likelihood of more axillary metastasis. Compared with the number of positive SLNs, the TTL is independent of the number of metastatic SLNs and a better predictor of further nodal metastasis. Although establishing specific cutoff-points of the TTL can be questionable because they may change in the future and increasingly become more patient specific, ...
Tópico(s): Multiple and Secondary Primary Cancers
2015 - American Association for Cancer Research | Cancer Research
Raquel Tur, Carlos De Grado, MR Martin, Javier de Castro, Elena Filipovich, BS Nicole A. Segovia, Jaime Ceballos, J. Parra, Rafael Revestido, JE Alés-Martínez,
Abstract Background: The study of sentinel lymph node (SNL) assessed by OSNA provides a new variable, Total Tumoral Load (TTL).This variable is defined as the amount of CK19 mRNA copies number in all positives SLN. TTL has been showed to predict the axillary node status and has been analysed to determine its usefulness in the axillary surgical management. Based on TTL values different cut-off points have been proposed (last 25.000 copies) to establish a new tool to practice axillary lymph node dissection ( ...
Tópico(s): Breast Cancer Treatment Studies
2018 - American Association for Cancer Research | Cancer Research
Vicente Peg, Martín Espinosa-Bravo, Begoña Vieites, F Vilardell, J. C Antunez, M de Salas Sancho, Irene Sansano, Sánchez JJ Delgado, Wladimir Bocca Vieira de Rezende Pinto, Francisco Gozalbo, A. Petit, IT Rubio,
... assess the intraoperative positive SLN total tumor load (TTL, defined as the amount of CK19 mRNA copies [ ... size of SLN and non-SLN metastasis, and TTL in each SLN. A total number of 701 ... Univariate logistic regression showed that, in addition to TTL (p < 0,001), the number of affected ... status. The multivariate logistic regression analysis showed that TTL is an independent predictor of metastatic non-SLNs, ... as compared to the number of affected SLN, TTL has a better ROC curve, as measured by ... lt; 0.001. Furthermore, in patients possessing a TTL<15000, the frequency of non-SLN metastasis ...
Tópico(s): Breast Cancer Treatment Studies
2012 - American Association for Cancer Research | Cancer Research
José E. Alés‐Martínez, Raquel Tur, Juan Parra, Ana de Castro, Jaime Ceballos, Rocı́o Martı́n, Rosa Ana Marcos, P. Nombela Blanco, MJose Velasco,
... creates a new continuous variable, Total Tumor Load (TTL), defined as the total number of CK19 mRNA ... LB 35%, HER2 7% and TN 5%. Mean TTL was 136,244 copies (see table). As of ... Median age, range (years)LOCOREGIONAL RELAPSEMETASTASIC BREAST CANCEREXITUSMean TTL with NO recurrenceMean TTL with recurrencePOSITIVE SLN122 (40%)59,8 (33-87) ...
Tópico(s): Breast Cancer Treatment Studies
2020 - American Association for Cancer Research | Cancer Research
V. Bordes, L. Campion, Pascal Jézéquel, Armelle Lefrançois, Florence Boiffard, Victoire Brillaud-Meflah, F. Dravet, Isabelle Jaffré, J-M Classe,
... Surg Oncol 2013): based on total tumoral load (TTL). TTL is defined as the addition of CK19 mRNA copies of each positive SLN (copies/μL). A TTL≥1.2 × 10(5) copies/ml (specificity=85. ...
Tópico(s): Breast Cancer Treatment Studies
2017 - American Association for Cancer Research | Cancer Research
Jing Zhang, Sheng Guo, Zheng‐Zheng Bao, Limei Shang, Xiao Wen, Jean‐Pierre Wery, Jinying Ning,
... Furthermore, the mutation status of tubulin tyrosine ligase TTL is significantly correlated with sensitivity to BEZ235. These ... Suppl):Abstract nr 1038. doi:10.1158/1538-7445.AM2015-1038
Tópico(s): Cancer Genomics and Diagnostics
2015 - American Association for Cancer Research | Cancer Research
Bohdan Wasylyk, Kostyantin Semenchenko, Christine Wasylyk, Jan Brants, Alain C. Jung, Joseph Abecassis,
Abstract Introduction: Microtubule-targeting drugs are used for the treatment of cancer; however, they are relatively non-specific and toxic, and more specific agents need to be developed. Microtubule functional diversity is governed by posttranslational modifications, such as de-tyrosine of β-tubulin by tubulin carboxypeptidases (TCP) and re-tyrosination by TTL (tubulin tyrosine ligase). Decreased levels of de-tyrosinated tubulin and TTL are associated with increased tumour growth and poor prognosis. ...
Tópico(s): Microtubule and mitosis dynamics
2012 - American Association for Cancer Research | Cancer Research
Rebecca A. Whipple, Michael A. Matrone, Edward H. Cho, Eric M. Balzer, Kimberly C. Tuttle, Michele Vítolo, Jennifer R. Yoon, Olga B. Ioffe, Jing Yang, Stuart S. Martin,
... to a downregulation of the tubulin tyrosine ligase (TTL) enzyme that catalyzes the readdition of tyrosine to ...
Tópico(s): Cancer Cells and Metastasis
2010 - American Association for Cancer Research | Cancer Research
Chandra Sekhar Amara, Chandrashekar R. Ambati, Venkatrao Vantaku, Piyarathna W b Danthasinghe, Sri Ramya Donepudi, Shiva Shankar Ravi, James M. Arnold, Vasantha Putluri, Gurkamal Chatta, Khurshid A. Guru, Hoda Badr, Martha K. Terris, Roni J. Bollag, Arun Sreekumar, Andrea B. Apolo, Nagireddy Putluri,
... COMT), Iodotyrosine Deiodinase (IYD), and Tubulin Tyrosine Ligase (TTL) showed a significant association with patient survival in ...
Tópico(s): Cancer, Lipids, and Metabolism
2019 - American Association for Cancer Research | Cancer Research
María A. Oliva, Beatriz Álvarez‐Bernad, Daniel Lucena‐Agell, Marta Martínez, María José Guillén, Gema Santamaría Núñez, María José Muñoz-Alonso, Eva M. Garrido-Martín, Pablo Avilés, Carmen Cuevas, J. Fernando Dı́az,
... X-ray crystallographic structure of the complex T2R-TTL with PM534 at a resolution of 2.45 ...
Tópico(s): Click Chemistry and Applications
2023 - American Association for Cancer Research | Cancer Research