Book.
1940 - Gale Group | World Scholar Latin America
Maria E Mendoza, María J. Monte, María A. Serrano, Marçal Pastor‐Anglada, Bruno Stieger, Peter J. Meier, Manuel Medarde, José J.G. Marı́n,
... regeneration and carcinogenesis were investigated. [14C] Tauro-ACA (TACA) uptake by Chinese hamster ovary cells expressing rat ... than that of [14C]taurocholic acid (TCA). Although TACA inhibited ATP-dependent TCA transport across plasma membrane ... bile salt export pump (Bsep), no ATP-dependent TACA transport was found. In rats, TACA was secreted into bile with no major biotransformation ... and longer half-life than TCA. In mice, TACA bile output was lower (−50%) than that of TCA, whereas TACA induced 9-fold higher bile flow than TCA. ...
Tópico(s): Liver Disease Diagnosis and Treatment
2003 - Elsevier BV | Journal of Lipid Research
Book.
1940 - Gale Group | World Scholar Latin America
Carolina Pellanda, Evelyne Ottiker, Christoph Strub, Verena Figueiredo, Theo Rufli, Georgios Imanidis, Christian Surber,
... Experiment 2) on the penetration of triamcinolone acetonide (TACA) into human stratum corneum (SC) in vivo. The ... of 15 healthy volunteers. In Experiment 1, single TACA doses (300 microg/cm(2) and 100 microg/ ... and multiple (3 x 100 microg/cm(2)) TACA doses were similarly applied. SC samples were harvested ... 8 and 24 h (Experiment 2). Corneocytes and TACA were quantified by UV/VIS spectroscopy and HPLC, respectively. TACA amounts penetrated into SC were statistically evaluated by a paired-sample t-test. In Experiment 1, TACA amounts within SC after application of 1 x ...
Tópico(s): Allergic Rhinitis and Sensitization
2006 - Springer Science+Business Media | Archives of Dermatological Research
Book.
1942 - Gale Group | World Scholar Latin America
Christoph Bitter, Katja Suter, Verena Figueiredo, Christian Pruente, Katja Hatz, Christian Surber,
All commercially available triamcinolone acetonide (TACA) suspensions, used for intravitreal treatment, contain retinal toxic vehicles (e.g., benzyl alcohol, solubilizer). Our aim was to find a convenient ... reproducible method to compound a completely preservative-free TACA suspension, adapted to the intraocular physiology, with consistent ... a newly developed method (Direct Suspending) to compound TACA suspensions for intravitreal injection. Parameters as TACA content (HPLC), particle size (microscopy and laser spectrometry), ...
Tópico(s): Glaucoma and retinal disorders
2008 - Mary Ann Liebert, Inc. | Journal of Ocular Pharmacology and Therapeutics
Book.
1940 - Gale Group | World Scholar Latin America
Carolina Pellanda, C. Strub, Verena Figueiredo, T. Rufli, Georgios Imanidis, Christian Surber,
... 2) application on the penetration of triamcinolone acetonide (TACA) into the stratum corneum. <i>Methods:</i> The ... experiment 1, 100 µg/cm<sup>2</sup> TACA in acetone were applied on 3 sites per ... 24 h (experiment 2) after application. Corneocytes and TACA were quantified by ultraviolet-visible spectroscopy and HPLC, respectively. The total TACA amount penetrated into the stratum corneum was evaluated by multifactor ANOVA. <i>Results:</i> TACA penetration into the stratum corneum with and without ...
Tópico(s): Contact Dermatitis and Allergies
2006 - Karger Publishers | Skin Pharmacology and Physiology
Book.
0000 - Gale Group | World Scholar Latin America
Sascha Thewes, Stefanie Krohn, Anika Schmith, Sergej Herzog, Thomas Stach, Barbara Weissenmayer, Rupert Mutzel,
... characterisation of the transcription factor activated by calcineurin (TacA) in the model organism Dictyostelium discoideum. TacA is a putative zinc-finger transcription factor orthologue ... dependent manner after Ca2+-stimulation. Nuclear export of TacA is partially dependent on GskA, the Dictyostelium orthologue of mammalian GSK3. The expression of tacA is developmentally regulated with its kinetics roughly paralleling calcineurin regulation. Silencing of tacA via RNAi leads to developmental defects and dysregulation ...
Tópico(s): Fungal and yeast genetics research
2012 - Elsevier BV | European Journal of Cell Biology
Book.
1945 - Gale Group | World Scholar Latin America
Produção Nacional
Revisado por pares
Marilis V. Marques, Suely Lopes Gomes, James W. Gober,
... a gene encoding a putative sigma54 activator, named tacA. The deduced amino acid sequence from tacA has high similarity to the proteins from the ... in other activators. The promoter region of the tacA gene contains a conserved sequence element present in the promoters of class II flagellar genes, and tacA shows a temporal pattern of expression similar to ... constructed an insertional mutant that is disrupted in tacA (strain SP2016), and an analysis of this strain ... flagellum, and displays a motile phenotype, indicating that tacA is not involved in the flagellar biogenesis pathway. ...
Tópico(s): Antibiotic Resistance in Bacteria
1997 - American Society for Microbiology | Journal of Bacteriology
Book.
1947 - Gale Group | World Scholar Latin America
M.-Mar González-Pérez, Juan L. Ramos, Marı́a-Trinidad Gallegos, Silvia Marqués,
... 53/−50 GGAG → AAAG)860097Pm 212 (−57/−54 TACA → GCAG)210024Pm 213 (−57/−54 TACA → GTTT)800089Pm 259 (−61/−58 CGGA → CCAA)350039Pm ... 740083Pm 245 (−49/−46, TGCA → AGGA; −57/−54 TACA → TTGG)601Pm 244 (−57/−54 TACA → GTTT; −67/−70, TGCA → ACGT)150016E. coli MC4100 ... the AAAAA sequence located at −41/−45, the TACA sequence between −54/−57, the CGGA sequence between − ... with a block of mutations at −54/−57 (TACA→TTGG) resulted in a mutant Pm promoter (Pm ... 6427-6434Crossref PubMed Google Scholar) suggested that the TACA submotif between −54/−57 was critical for transcription ...
Tópico(s): Microbial Natural Products and Biosynthesis
1999 - Elsevier BV | Journal of Biological Chemistry
Book.
1947 - Gale Group | World Scholar Latin America
Yanfei Xu, Alessandro Sette, John Sidney, Sandra Gendler, Alessandra Franco,
... use of glycopeptides containing tumour-associated carbohydrate antigens (TACA) as potential preventive vaccines for carcinomas. Our recent ... CD8+ T cells (CTL) are capable of recognizing TACA in a conventional class I MHC-restricted fashion. ... a disaccharide, and Tn, its immediate precursor, are TACA largely expressed in carcinomas. TF and Tn can ... generated using this strategy are capable of recognizing TACA-expressing tumours in vitro, suggesting that glycopeptides are ... sequences of endogenously synthesized glycopeptides are unknown, the TACA-specific T cell repertoire elicited by carbohydrate-based ...
Tópico(s): vaccines and immunoinformatics approaches
2005 - Wiley | Immunology and Cell Biology
Book.
1945 - Gale Group | World Scholar Latin America
Craig R. Nitschke, John L. Innes,
... of the developed model, tree and climate assessment (TACA), was tested within the interior Douglas-fir ecosystem in south-central British Columbia. TACA modelled the current potential tree species composition of ... a new ecosystem over the next 100 years. TACA showed that it can be an effective tool ... sensitive stage of development, the regeneration phase. The TACA model was able to identify the degree of ... enabled a measure of vulnerability to be quantified. TACA could be useful to forest managers as a ...
Tópico(s): Species Distribution and Climate Change
2007 - Elsevier BV | Ecological Modelling
Book.
1945 - Gale Group | World Scholar Latin America
Carolina Pellanda, Monika Weber, Andreas J. Bircher, Christian Surber,
... in atopic dermatitis (AD). Later, fraudulent triamcinolone acetonide (TACA) was detected at low doses (16–40 µg/g) in Lichtena. This suggested that TACA may be effective at much lower concentrations than ... investigate the efficacy in AD of low-dose TACA in Lichtena compared to plain Lichtena. <i>Methods:</ ... 1 month with Lichtena plus 25 µg/g TACA (= verum) and plain Lichtena (= placebo). The severity of ... was observed using plain Lichtena. <i>Conclusions:</i> TACA displayed a significant improvement of AD at doses ...
Tópico(s): Food Allergy and Anaphylaxis Research
2005 - Karger Publishers | Dermatology
Book.
1940 - Gale Group | World Scholar Latin America
... the present knowledge of tumor-associated carbohydrate antigens (TACA's). It also discusses the pathobiological and functional significance of TACA's. A large number of monoclonal antibody (mAbs) ... the classical concept of tumor-associated carbohydrate antigens (TACA's) was revived. A ganglio-series TACA, fucosyl-GM1, is accumulated in small cell lung ... The only clear example of a globo-series TACA is Burkitt lymphoma antigen (BLA).
Tópico(s): Lung Cancer Research Studies
1996 - Elsevier BV | New comprehensive biochemistry
Book.
1942 - Gale Group | World Scholar Latin America
Jane E. Carland, Andrew J. Moorhouse, Peter H. Barry, Graham A.R. Johnston, Mary Chebib,
... 5,6,7-tetrahydroisoxazole2.0+/– pyridine-3-ol; TACA, trans-4-aminocrotonic acid; CACA, cis-4-aminocrotonic ... 5,6,7-tetrahydroisoxazole2.0+/– pyridine-3-ol; TACA, trans-4-aminocrotonic acid; CACA, cis-4-aminocrotonic ... from Sigma Chemical Co. Trans-4-aminocrotonic acid (TACA), cis-4-aminocrotonic acid (CACA), trans-2-(+/–)-(aminomethyl) ... potencies and efficacies of the full agonists, GABA, TACA, and (+/–)-CAMP differed at mutant receptors compared with ... with the exception of a significant increase for TACA (p < 0.001, n = 3) and a significant ∼ ...
Tópico(s): Ion channel regulation and function
2004 - Elsevier BV | Journal of Biological Chemistry
Book.
1942 - Gale Group | World Scholar Latin America
Paul James, Michail N. Isupov, C. Sayer, Vahid Saneei, S. Van den Berg, Maria G. Lioliou, Hans Kristian Kotlar, Jennifer A. Littlechild,
... bicarbonate. A thermophilic Thermovibrio ammonificans α-carbonic anhydrase (TaCA) has been expressed in Escherichia coli and structurally and biochemically characterized. The crystal structure of TaCA has been determined in its native form and ... to mimic the environment of the periplasmic space, TaCA has increased thermostability, retaining 90% activity after incubation ... industrial carbon-dioxide capture. The reduction of all TaCA cysteines resulted in dissociation of the tetrameric molecule ... reduced thermostability. Unlike other characterized α-carbonic anhydrases, TaCA does not display esterase activity towards p-nitrophenyl ...
Tópico(s): Hemoglobin structure and function
2014 - Wiley | Acta Crystallographica Section D Biological Crystallography
Book.
1940 - Gale Group | World Scholar Latin America
Suttipun Sungsuwan, Zhaojun Yin, Xuefei Huang,
... it is highly challenging to elicit strong anti-TACA immune responses. With their high biocompatibilities and large surface areas, magnetic NPs were synthesized for TACA delivery. The magnetic NPs were coated with phospholipid-functionalized TACA glycopeptides through hydrophobic–hydrophobic interactions without the need ... a new and simple platform for multivalently displaying TACA and boosting anti-TACA immune responses without the need for a typical ...
Tópico(s): Glycosylation and Glycoproteins Research
2015 - American Chemical Society | ACS Applied Materials & Interfaces
Book.
1940 - Gale Group | World Scholar Latin America
Mary Chebib, Robert J. Vandenberg, Graham A.R. Johnston,
... Aminobutyric acid (GABA) and trans ‐4‐aminocrotonic acid (TACA) have been shown to activate GABA C receptors. ... C2, C3, C4 and N‐substituted GABA and TACA analogues were examined for activity at GABA C ... group in the C2 position of GABA or TACA is tolerated at GABA C receptors. However, there ... C3, C4 and nitrogen positions of GABA and TACA. Molecular modelling studies on a range of active ...
Tópico(s): Nicotinic Acetylcholine Receptors Study
1997 - Wiley | British Journal of Pharmacology