Kosei Nagata, Hironori Hojo, Song Ho Chang, Hiroyuki Okada, Fumiko Yano, Ryota Chijimatsu, Yasunori Omata, Daisuke Mori, Yuma Makii, Manabu Kawata, Taizo Kaneko, Yasuhide Iwanaga, Hideki Nakamoto, Yuji Maenohara, Naohiro Tachibana, Hisatoshi Ishikura, Junya Higuchi, Yuki Taniguchi, Shinsuke Ohba, Ung‐il Chung, Sakae Tanaka, Taku Saito,
Abstract The Runt-related transcription factor (Runx) family plays various roles in the homeostasis of cartilage. Here, we examined the role of Runx2 and Runx3 for osteoarthritis development in vivo and in vitro. Runx3- knockout mice exhibited accelerated osteoarthritis following surgical induction, accompanied by decreased expression of lubricin and aggrecan. Meanwhile, Runx2 conditional knockout mice showed biphasic phenotypes: heterozygous knockout inhibited osteoarthritis and decreased matrix ...
Tópico(s): Chemokine receptors and signaling
2022 - Nature Portfolio | Nature Communications
Tomoyuki Igawa, Shinya Ishii, Tatsuhiko Tachibana, Atsuhiko Maeda, Yoshinobu Higuchi, Shin Shimaoka, Chifumi Moriyama, Tomoyuki Watanabe, Ryoko Takubo, Yoshiaki Doi, Tetsuya Wakabayashi, Akira Hayasaka, Shoujiro Kadono, Takuya Miyazaki, Kenta Haraya, Yasuo Sekimori, Tetsuo Kojima, Yoshiaki Nabuchi, Yoshinori Aso, Yoshiki Kawabe, Kunihiro Hattori,
Tópico(s): T-cell and B-cell Immunology
2010 - Nature Portfolio | Nature Biotechnology
S. Tachibana, Hiroyoshi Higuchi, K. Takasugi, K. Sasaki, Toshiaki Yamanaka, Y. Nakagome,
The dual-sensing-latch circuit proposed here can solve the synchronization problem of the conventional wave-pipelined SRAM and the proposed source-biased self-resetting circuit reduces both the cycle and access time of cache SRAM's. A 16-kb SRAM using these circuit techniques was designed, and was fabricated with 0.25-/spl mu/m CMOS technology. Simulation results indicate that this SRAM has a typical clock access time of 2.6 ns at 2.5-V supply voltage and a worst minimum cycle time of 2.6 ns. >
Tópico(s): Low-power high-performance VLSI design
1995 - Institute of Electrical and Electronics Engineers | IEEE Journal of Solid-State Circuits
T Ideura, Takehiko Muramatsu, Makoto Higuchi, Naoki Tachibana, Kazuhiko Hora, Kendo Kiyosawa,
Tópico(s): Pharmacological Effects and Toxicity Studies
2000 - Oxford University Press | Nephrology Dialysis Transplantation
Hiroshi Adachi, Kanako Ishihara, Hisatsugu Tachibana, Nobuyuki Oka, Yujiro Higuchi, Hiroshi Takashima, Yukihiro Yoneda, Yasufumi Kageyama,
ABSTRACT Introduction: Adult‐onset Krabbe disease is clinically rare and usually affects the pyramidal tracts in the central nervous system. Patients develop a spastic gait, and peripheral neuropathy sometimes occurs simultaneously. Methods: A 55‐year‐old woman with consanguineous parents developed slowly progressive, asymmetric muscle weakness and atrophy in her forearms, while her ability to walk remained unaffected without pyramidal tract signs after onset at age 51 years. Results: Nerve conduction ...
Tópico(s): Trypanosoma species research and implications
2016 - Wiley | Muscle & Nerve
Takashi Saitoh, Y. Tachibana, Yoshiki Higuchi, Hiroshi Hori, Hideo Akutsu,
Single crystals of cytochrome c3 from Desulfovibrio vulgaris Miyazaki F were examined by EPR at cryogenic temperature. The principal values and the eigenvectors are determined. The four sets of EPR...
Tópico(s): ATP Synthase and ATPases Research
2004 - Oxford University Press | Bulletin of the Chemical Society of Japan
Tomoyuki Igawa, Atsuhiko Maeda, Kenta Haraya, Tatsuhiko Tachibana, Yuki Iwayanagi, Futa Mimoto, Yoshinobu Higuchi, Shinya Ishii, Shigero Tamba, Naoka Hironiwa, Kozue Nagano, Tetsuya Wakabayashi, Hiroyuki Tsunoda, Kunihiro Hattori,
Monoclonal antibodies are widely used to target disease-related antigens. However, because conventional antibody binds to the antigen but cannot eliminate the antigen from plasma, and rather increases the plasma antigen concentration by reducing the clearance of the antigen, some clinically important antigens are still difficult to target with monoclonal antibodies because of the huge dosages required. While conventional antibody can only bind to the antigen, some natural endocytic receptors not ...
Tópico(s): Advanced Biosensing Techniques and Applications
2013 - Public Library of Science | PLoS ONE
Makoto Suzuki, S. Tachibana, Atsuo Watanabe, S. Shukuri, Hiroyoshi Higuchi, T. Nagano, K. Shimohigashi,
A 16-kbit BiCMOS ECL SRAM with a typical address access time of 3.5 ns and 500-mW power dissipation was developed. The RAM was fabricated using half-micrometer, triple-poly, and triple-metal BiCMOS technology. The fast access time with moderate power dissipation has been achieved using new circuit techniques: a grounded-gate, nonlatching-type level converter with a wired-OR predecoder and a direct column sensing scheme having a cascode differential amplifier. As a result of extensive use of high- ...
Tópico(s): Parallel Computing and Optimization Techniques
1989 - Institute of Electrical and Electronics Engineers | IEEE Journal of Solid-State Circuits
Hidenobu Tachibana, Masahiko Omatsu, Ko Higuchi, Tokuo Umeda,
It is not easy to connect a web-based server with an existing DICOM server, and using a web-based server on the INTERNET has risks. In this study, we designed and developed the secure DICOM-Network Attached Server (DICOM-NAS) through which the DICOM server in a hospital-Local Area Network (LAN) was connected to the INTERNET. After receiving a Client's image export request, the DICOM-NAS sent it to the DICOM server with DICOM protocol. The server then provided DICOM images to the DICOM-NAS, which transferred ...
Tópico(s): Lung Cancer Diagnosis and Treatment
2006 - Elsevier BV | Computer Methods and Programs in Biomedicine
Kanta Tachibana, Kazuya Yashiro, Jun Miyazaki, Yasuo Ikegami, Mitsuru Higuchi,
Although it is clear that rowers have a large muscle mass, their distribution of muscle mass and which of the main motions in rowing mediates muscle hypertrophy in each body part are unclear. We examine the relationships between partial motion power in rowing and muscle cross-sectional area of the thigh, lower back, and upper arms. Sixty young rowers (39 males and 21 females) participated in the study. Joint positions and forces were measured by video cameras and rowing ergometer software, respectively. ...
Tópico(s): Muscle activation and electromyography studies
2007 - Taylor & Francis | Sports Biomechanics
Tomokazu Shohji, Atsushi Tachibana, Sousuke Higuchi, Norio Nakata, Daichi Hayashi, Yo Katoh,
We aimed to develop a software for facilitating absorbed dose per pixel (pixel dose) calculation using a size-specific dose estimate (SSDE). We calculated the pixel dose at nine equal points inserted into the radiophotoluminescence glass dosemeter (RPLD) and compared the pixel dose with the measured doses using RPLD. With this method, the relative errors of average pixel dose was -0.1% for adults and 2.86, 3.36 and 1.17% for those aged 10, 5 and 1 years without tube current modulation, respectively. ...
Tópico(s): Radiation Detection and Scintillator Technologies
2018 - Oxford University Press | Radiation Protection Dosimetry
Hiroshi Shima, Mitsuhiro Hasegawa, Osamu Tachibana, Motohiro Nomura, Junkoh Yamashita, Y. Ozaki, Jun Kawai, Masanori Higuchi, Hisashi Kado,
To investigate whether the ocular dominance affects laterality in the activity of the primary visual cortex, we examined the relationship between the ocular dominance and latency or dipole moment measured by checkerboard-pattern and magnetoencephalography in 11 right-handed healthy male participants. Participants with left-eye dominance showed a dipole moment of 21.5+/-6.1 nAm with left-eye stimulation and 16.1+/-3.6 nAm with right, whereas those with right-eye dominance showed a dipole moment of ...
Tópico(s): Vestibular and auditory disorders
2010 - Lippincott Williams & Wilkins | Neuroreport
Stefano Guzzetti, Giorgio Costantino, Camilla Fundarò,
... 10.1371/journal.pone.0237244, 15:8, (e0237244) Higuchi S, Kabeya Y, Matsushita K, Arai N, Tachibana K, Tanaka R, Kawachi R, Takei H, Suzuki ...
Tópico(s): Drug-Induced Adverse Reactions
2002 - Lippincott Williams & Wilkins | Circulation
Takuya Urushihata, Hiroyuki Takuwa, Chie Seki, Yasuhiko Tachibana, Manami Takahashi, Jeff Kershaw, Yuhei Takado, Ichio Aoki, Makoto Higuchi, Hiroshi Ito, Takayuki Obata,
Chronic cerebral hypoperfusion model mice were created by unilateral common carotid artery occlusion (UCCAO) surgery, which does not cause cerebral infarction, but which does cause long-term reduction in cerebral blood flow (CBF) to the occluded side. Cognitive dysfunction in this mouse model has been demonstrated in behavioral experiments, but neuron density change was not found in a previous positron emission tomography (PET) study. As a next step, in this study we investigated the injury of neuronal ...
Tópico(s): Cerebrovascular and Carotid Artery Diseases
2018 - Japan Society of Magnetic Resonance in Medicine | Magnetic Resonance in Medical Sciences
Shiro Hoshida, Koichi Tachibana, Yukinori Shinoda, Tomoko Minamisaka, Takahisa Yamada, Yoshiharu Higuchi, Yusuke Nakagawa, Haruhiko Abe, Hisakazu Fuji, Yoshio Yasumura, Shungo Hikoso, Daisaku Nakatani, Yasushi Sakata,
The severity of diastolic dysfunction is assessed using a combination of several indices of left atrial (LA) volume overload and LA pressure overload. We aimed to clarify which overload is more associated with the prognosis in patients with heart failure and preserved ejection fraction (HFpEF).A prospective, multicenter observational registry of collaborating hospitals in Osaka, Japan.We enrolled hospitalised patients with HFpEF showing sinus rhythm (men, 79; women, 113). Blood tests and transthoracic ...
Tópico(s): Heart Failure Treatment and Management
2021 - BMJ | BMJ Open
Takayuki Onishi, Yuko Onishi, Keiko Tachibana, Kensuke Kasano, Shoko Hachiya, Hirotaka Muramoto, Koji Higuchi, Atsushi Suzuki, Isshi Kobayashi, Shigeo Umezawa, Akihiro Niwa,
Tópico(s): Trauma Management and Diagnosis
2014 - Springer Nature | Journal of Echocardiography
Satoshi Higuchi, Yusuke Kabeya, Kenichi Matsushita, Nobuaki Arai, Keisei Tachibana, Ryota Tanaka, Riken Kawachi, Hidefumi Takei, Yutaka Suzuki, Masaharu Kogure, Yorihisa Imanishi, Kiyoshi Moriyama, Tomoko Yorozu, Koichiro Saito, Nobutsugu Abe, Masanori Sugiyama, Haruhiko Kondo, Hideaki Yoshino,
Background Perioperative atrial fibrillation (POAF) is one of the common arrhythmias in the setting of non-cardiac surgeries for malignancy. As POAF may cause subsequent adverse events, it is important to confirm its characteristics and risk factors. Materials and methods The prospective cohort study of surveillance for perioperative atrial fibrillation recurrence (PREDICT AF RECURRENCE) is an ongoing prospective, single-center, observational study that aims to illustrate the clinical impact of POAF ...
Tópico(s): Cardiac Imaging and Diagnostics
2019 - Public Library of Science | PLoS ONE
Satoshi Higuchi, Yusuke Kabeya, Kenichi Matsushita, Nobuaki Arai, Keisei Tachibana, Ryota Tanaka, Riken Kawachi, Hidefumi Takei, Yutaka Suzuki, Masaharu Kogure, Yorihisa Imanishi, Kiyoshi Moriyama, Masanori Sugiyama, Tomoko Yorozu, Koichiro Saito, Nobutsugu Abe, Haruhiko Kondo, Hideaki Yoshino,
Background Perioperative atrial fibrillation (POAF) in noncardiac surgeries is common. However, it is unclear whether such atrial fibrillation (AF) recurs in the long term. Methods This study was a prospective, single-center, observational study that included patients who underwent noncardiac surgeries for malignancies. Patients were followed up for 1 year to evaluate the incidence of AF, ischemic stroke, and mortality. An event-triggered recorder was used in patients with POAF. The incidences were ...
Tópico(s): Coronary Interventions and Diagnostics
2019 - Elsevier BV | Canadian Journal of Cardiology
Hiroto Tachibana, S. Kamanaru, Tatsuya Mima, Masayuki Sohgawa, Takeshi Kanashima, Masanori Okuyama, Kaoru Yamashita, Minoru Noda, Haruo Noma, M. Higuchi,
Tactile array sensors with three inclined micro-cantilevers embedded in elastomer, which can detect both normal and shear forces, have been designed and fabricated. The inclined cantilevers consist of multilayer of Polymer/NiCr/SiN/Si and the normal and shear forces are detected as resistance change of NiCr thin film induced by deformation of the cantilever. This tactile sensor has sensitivity linear to normal and shear forces. Moreover, this sensor can detect normal and shear force by the resistance ...
Tópico(s): Innovative Energy Harvesting Technologies
2010 - Institute of Electrical Engineers of Japan | IEEJ Transactions on Sensors and Micromachines
Takuya Urushihata, Hiroyuki Takuwa, Manami Takahashi, Jeff Kershaw, Yasuhiko Tachibana, Nobuhiro Nitta, S. Shibata, Masato Yasui, Makoto Higuchi, Takayuki Obata,
Abstract Background Aquaporin-4 is a membrane channel protein that is highly expressed in brain astrocytes and facilitates the transport of water molecules. It has been suggested that suppression of aquaporin-4 function may be an effective treatment for reducing cellular edema after cerebral infarction. It is therefore important to develop clinically applicable measurement systems to evaluate and better understand the effects of aquaporin-4 suppression on the living body. Methods Animal models of ...
Tópico(s): Advanced MRI Techniques and Applications
2021 - Springer Science+Business Media | European Radiology Experimental
Kenta Watanabe, Yusei Higuchi, Mizuki Shimmura, Masato Tachibana, Masahiro Fujishima, Takashi Shimizu, Masahisa Watarai,
Legionella pneumophila, an intracellular human pathogen, establishes intracellular relationships with several protist hosts, including Paramecium caudatum. L. pneumophila can escape the normal digestion process and establish intracellular relationships in Paramecium. In this study, we identify new Paramecium strains that significantly reduce the number of L. pneumophila during infection. As a result, stable intracellular relationships between L. pneumophila and these Paramecium strains were not ...
Tópico(s): Bacterial biofilms and quorum sensing
2020 - Frontiers Media | Frontiers in Microbiology
Satoshi Higuchi, Yusuke Kabeya, Kenichi Matsushita, Keisei Tachibana, Riken Kawachi, Hidefumi Takei, Yutaka Suzuki, Nobutsugu Abe, Yorihisa Imanishi, Kiyoshi Moriyama, Tomoko Yorozu, Koichiro Saito, Masanori Sugiyama, Haruhiko Kondo, Hideaki Yoshino,
A previous retrospective cohort study established the relationship between perioperative atrial fibrillation (POAF) and subsequent mortality and stroke. However, the details regarding the cause of death and etiology of stroke remain unclear. The prospective cohort study of surveillance for perioperative atrial fibrillation recurrence in major non-cardiac surgery for malignancy (PREDICT AF RECURRENCE) registry is an ongoing prospective cohort study to elucidate the long-term recurrence rate and the ...
Tópico(s): Cardiac, Anesthesia and Surgical Outcomes
2018 - BioMed Central | BMC Cardiovascular Disorders
Hirotatsu Kiuchi, Michio Tajima, Fumito Higuchi, Atsushi Ogura, Nobuhito Iida, Shoji Tachibana, Isao Masada, Eiichi Nishijima,
We attempted the quantification of carbon concentration in Czochralski-grown Si crystals for solar cells by luminescence activation in the concentration range lower than the detection limit of IR absorption spectroscopy. A positive correlation was found between the relative intensity of the C-line and the substitutional carbon (Cs) concentration determined by IR absorption in the low 1015 cm−3 range. The detection limit was estimated to be approximately 5 × 1012 cm−3. We measured and compared the Cs ...
Tópico(s): Integrated Circuits and Semiconductor Failure Analysis
2017 - Institute of Physics | Japanese Journal of Applied Physics
Hisayuki Higuchi, S. Tachibana, Masataka Minami, Takahiro Nagano,
Tópico(s): Magnetic properties of thin films
1996 - Institute of Electronics, Information and Communication Engineers | IEICE Transactions on Electronics
Ryota Chijimatsu, Satoshi Miwa, Gensuke Okamura, Junya Miyahara, Naohiro Tachibana, Hisatoshi Ishikura, Junya Higuchi, Yuji Maenohara, Shinsaku Tsuji, Shin Sameshima, Kentaro Takagi, Keiu Nakazato, Kohei Kawaguchi, Ryota Yamagami, Hiroshi Inui, Shuji Taketomi, Sakae Tanaka, Taku Saito,
Abstract Background Somatic stem cell transplantation has been performed for cartilage injury, but the reparative mechanisms are still conflicting. The chondrogenic potential of stem cells are thought as promising features for cartilage therapy; however, the correlation between their potential for chondrogenesis in vitro and in vivo remains undefined. The purpose of this study was to investigate the intrinsic chondrogenic condition depends on cell types and explore an indicator to select useful ...
Tópico(s): Mesenchymal stem cell research
2021 - BioMed Central | Stem Cell Research & Therapy
K. Kitazato, R. E. Milliken, Takahiro Iwata, Masanao Abe, M. Ohtake, Shuji Matsuura, Y. Takagi, Tomoki Nakamura, T. Hiroi, M. Matsuoka, Lucie Riu, Yusuke Nakauchi, Kohji Tsumura, T. Arai, Hiroki Senshu, Naru Hirata, M. A. Barucci, R. Brunetto, C. Pilorget, F. Poulet, Jean‐Pierre Bibring, D. L. Domingue, F. Vilas, D. Takir, E. Palomba, A. Galiano, D. Perna, Takahito Osawa, M. Komatsu, Aiko Nakato, T. Arai, N. Takato, Tsuneo Matsunaga, M. Arakawa, Takanao Saiki, Koji Wada, T. Kadono, Hiroshi IMAMURA, Hajime Yano, K. Shirai, M. Hayakawa, Chisato Okamoto, H. Sawada, Kazunori Ogawa, Y. Iijima, Seiji Sugita, Rie Honda, Tomokatsu Morota, S. Kameda, Eri Tatsumi, Yuichiro Cho, Kazuo Yoshioka, Y. Yokota, Naoya Sakatani, M. Yamada, Toru Kouyama, H. Suzuki, C. Honda, Noriyuki Namiki, T. Mizuno, Koji Matsumoto, H. Noda, Yoshiaki Ishihara, Ryuhei Yamada, Keiko Yamamoto, F. Yoshida, Shinsuke Abe, Arika Higuchi, Yukio Yamamoto, T. Okada, Yuri Shimaki, Rina Noguchi, An Miura, N. Hirata, Shogo Tachibana, H. Yabuta, M. Ishiguro, H. Ikeda, Hiroshi Takeuchi, T. Shimada, Osamu Mori, S Hosoda, Ryudo Tsukizaki, Stefania Soldini, Masanobu Ozaki, Fuyuto Terui, Naoko Ogawa, Yuya Mimasu, G. Ono, K. Yoshikawa, Chikako Hirose, Atsushi Fujii, T. Takahashi, Shota Kikuchi, Yuto Takei, T. Yamaguchi, Satoru Nakazawa, S. Tanaka, Masaaki Yoshikawa, Sei‐ichiro Watanabe, Yuichi Tsuda,
Tópico(s): Isotope Analysis in Ecology
2021 - Nature Portfolio | Nature Astronomy
Shigekazu Sugino, Daisuke Konno, Yosuke Kawai, Masao Nagasaki, Yasuhiro Endo, Tomo Hayase, Misako Yamazaki-Higuchi, Yukihiro Kumeta, Shunsuke Tachibana, Katsuhiko Saito, Jun Suzuki, Kanta Kido, Nahoko Kurosawa, Akiyoshi Namiki, Masanori Yamauchi,
Abstract Background Genetic factors such as single-nucleotide polymorphisms (SNPs) play a key role in the development of postoperative nausea and vomiting (PONV). However, previous findings are not widely applicable to different populations because of population-specific genetic variation. We developed a Japanese-specific DNA microarray for high-throughput genotyping. The aim of the current study was to identify SNPs associated with PONV on a genome-wide scale using this microarray in a sample of ...
Tópico(s): Nausea and vomiting management
2020 - BioMed Central | Human Genomics
Daisuke Kawai, Ryo Takahashi, Tatsuya Kamima, Hiromi Baba, Toshijiro Yamamoto, Yoko Kubo, Satoru Ishibashi, Yoshihiro Higuchi, K. Tani, Norifumi Mizuno, Shunta Jinno, H. Tachibana,
The aim of the present investigation was to evaluate the dosimetric variation regarding the analytical anisotropic algorithm (AAA) relative to other algorithms in lung stereotactic body radiation therapy (SBRT). We conducted a multi-institutional study involving six institutions using a secondary check program and compared the AAA to the Acuros XB (AXB) in two institutions.All lung SBRT plans (128 patients) were generated using the AAA, pencil beam convolution with the Batho (PBC-B) and adaptive convolve ( ...
Tópico(s): Radiation Dose and Imaging
2017 - Elsevier BV | Physica Medica
Ryo Takahashi, H. Tachibana, Tatsuya Kamima, M Itano, Takeshi Yamazaki, Shun Ishibashi, Yoshinori Higuchi, Hidetoshi Shimizu, T Yamamoto, M Yamashita, H. Baba, Y. Sugawara, Aya Sato, Satoshi Nishiyama, Daisuke Kawai, Satoshi Miyaoka,
Purpose: To show the results of a multi‐institutional study of the independent dose verification for conventional, Stereotactic radiosurgery and body radiotherapy (SRS and SBRT) plans based on the action level of AAPM TG‐114. Methods: This study was performed at 12 institutions in Japan. To eliminate the bias of independent dose verification program (Indp), all of the institutions used the same CT‐based independent dose verification software (Simple MU Analysis, Triangle Products, JP) with the Clarkson‐ ...
Tópico(s): Radiomics and Machine Learning in Medical Imaging
2015 - Wiley | Medical Physics
S. Tachibana, Hisayuki Higuchi, Koichi Takasugi, Katsuro Sasaki, Toshiaki Yamanaka, Y. Nakagome,
Tópico(s): Semiconductor materials and devices
1995 - Institute of Electronics, Information and Communication Engineers | IEICE Transactions on Electronics