Yuka Taniguchi, Kenji Watanabe, Makoto Mochii,
... effect of the hedgehog signal inhibitor, cyclopamine, on the tail regeneration. In Xenopus, sonic hedgehog is expressed exclusively in the notochord but not in the spinal cord of ...
Tópico(s): Aquatic life and conservation
2014 - BioMed Central | BMC Developmental Biology
Ni Qiu, Cao Li, Valentin David, L. Darryl Quarles, Zhousheng Xiao,
... and Kif3a+/Δ heterozygous mice. The administration of sonic hedgehog, overexpression of Gli2, and the PC1 C-tail construct all increased Gli2 and Runx2-II expression, ...
Tópico(s): Epigenetics and DNA Methylation
2010 - Public Library of Science | PLoS ONE
Maha El Shahawy, Claes-Göran Reibring, K. Hallberg, Cynthia L. Neben, Pauline Marangoni, Brian D. Harfe, Ophir D. Klein, Anders Linde, Amel Gritli-Linde,
... that during development of ontogenetically different organs, including the tail, genital tubercle, and secondary palate, Sonic hedgehog (SHH) loss-of-function causes anomalies phenocopying those induced by enhanced retinoic acid signaling and that SHH is required to prevent supraphysiological activation of retinoic signaling through maintenance and reinforcement of expression of the Cyp26 genes. Furthermore, in other tissues and organs, ...
Tópico(s): Congenital Ear and Nasal Anomalies
2019 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Zerina Johanson, Mikiko Tanaka, Natalie Chaplin, Moya Meredith Smith,
... fins. An identical organized pattern is observed in tail scales of Scyliorhinus canicula (catshark), where the expression of sonic hedgehog signal is restricted to the epithelium of developing ... scale pocket. Regulation of iterative scale position by sonic hedgehog is deeply conserved in vertebrate phylogeny. These scales also reveal an archaic histological structure of a dentine type found in the oldest known shark scales from the Ordovician and Silurian. This combination of regulated pattern and ancient dentine occurs only in the tail, representing the primary scalation. Scattered body scales in ...
Tópico(s): Bone Tumor Diagnosis and Treatments
2007 - Royal Society | Biology Letters
... neural tube; yet in floating head and no tail mutants, floor plate cells develop in the absence of differentiating notochord. Expression of sonic hedgehog by newly-forming axial mesoderm at gastrulation may ...
Tópico(s):
1997 - Oxford University Press | American Zoologist
Shuk Han Cheng, Albert Wai, Chun Hung So, Rudolf S.S. Wu,
... were associated with lack of expression of the sonic hedgehog gene, which controls the patterning of the neural tube and somites. Genes involved in tail formations, such as evenskipped 1 and no tail, ...
Tópico(s): Heavy Metal Exposure and Toxicity
2000 - Wiley | Environmental Toxicology and Chemistry
Shuk Han Cheng, Albert Wai, Chun Hung So, Rudolf S.S. Wu,
... were associated with lack of expression of the sonic hedgehog gene, which controls the patterning of the neural tube and somites. Genes involved in tail formations, such as evenskipped 1 and no tail, ...
Tópico(s): Heavy Metal Exposure and Toxicity
2000 - Wiley | Environmental Toxicology and Chemistry
Diane Pelzer, Lauren S. Phipps, Raphaël Thuret, Carlos J. Gallardo-Dodd, Syed Murtuza Baker, Karel Dorey,
... Lin & Slack, 2008; Love et al, 2013). Furthermore, Sonic hedgehog (Shh) signalling is also required for tail regeneration (Beck et al, 2003; Hamilton et al, 2021) and induces Foxm1 expression in the developing cerebellar granule neuron precursors (Schüller et al, ...
Tópico(s): Neurogenesis and neuroplasticity mechanisms
2021 - Springer Nature | EMBO Reports
Hyuk Moon, Hyun-Jung Park, Simon Weonsang Ro,
... c-Myc in diverse genetic environments in which the Ras, Wnt/β-catenin, Sonic hedgehog, or P53 pathways were either activated or inactivated. Materials and Methods: Hydrodynamic tail vein injection was employed to administer expression transposons and generate transgenic livers expressing c-Myc together with a constitutively active form of RAS (HRAS G12V ), β-catenin (β-catenin S33Y ), Smo (SmoM2), or short hairpin RNA targeting P53 (shp53). Results: c-Myc was most tumorigenic when the RAS signaling pathway was activated, whereas no tumors ...
Tópico(s): Cancer-related gene regulation
2021 - International Institute of Anticancer Research (IIAR) Conferences 1997. Athens, Greece. Abstracts | Anticancer Research
... epithelial anlage of the BF. The expression of sonic hedgehog and its receptor in the embryonic gut, but not in the BF, further supports an ectodermal origin for the bursal rudiment. Using chick-quail chimeras, quail tail bud ectoderm was homotopically transplanted into ectoderm-ablated ...
Tópico(s): Developmental Biology and Gene Regulation
2010 - The Company of Biologists | Development
Stefanie Wachter, Jamin Jung, Shahaan Shafiq, J. Basquin, Cécile Fort, Philippe Bastin, Esben Lorentzen,
... sensory perception, and several signaling pathways, such as sonic hedgehog and PDGFRα signaling (Huangfu et al, 2003; Kohl et al, 2003; San Agustin et al, 2015; Salinas et al, 2017; Schneider et al, 2005). Cilia are tail-like appendages protruding from the cell surface of nearly every eukaryotic cell type ...
Tópico(s): Toxoplasma gondii Research Studies
2019 - Springer Nature | The EMBO Journal
Thomas P. Lozito, Ricardo Londoño, Aaron X. Sun, Megan L. Hudnall,
... tails form ependymal tubes (ETs) that, like embryonic tail neural tubes (NTs), induce cartilage differentiation in surrounding cells via sonic hedgehog (Shh) signaling. However, adult ETs lack characteristically roof plate-associated structures and express Shh throughout their circumferences, resulting in the formation of unpatterned cartilage tubes. Both NTs and ...
Tópico(s): Hippo pathway signaling and YAP/TAZ
2021 - Nature Portfolio | Nature Communications
María-Isabel Yuseff, Pamela Farfán, Guojun Bu, María‐Paz Marzolo,
... molecules such as parathyroid hormone and the morphogen sonic hedgehog. An important characteristic of megalin is its high endocytic activity, which is mediated by tyrosine‐based endocytic motifs within the receptor's cytoplasmic tail. This domain also harbors several putative consensus phosphorylation ...
Tópico(s):
2007 - Wiley | Traffic
David A. Quigley, Eve Kandyba, Phillips Huang, Kyle Halliwill, Jonas Sjölund, Facundo Pelorosso, Christine E. Wong, Gillian L. Hirst, Di Wu, Reyno Delrosario, Atul Kumar, Allan Balmain,
... to specific cell types and signaling pathways, including sonic hedgehog (Shh), Wnt, Lgr family stem cell markers, and keratins, differed at these tissue sites, suggesting mechanisms for the differential susceptibility of dorsal and tail skin to development of skin diseases and tumorigenesis. ...
Tópico(s): Genomics and Chromatin Dynamics
2016 - Cell Press | Cell Reports
Eric S. Weinberg, Miguel L. Allende, Christina Kelly, Aboulmagd Abdelhamid, Tohru Murakami, Peter Andermann, O. Geoffrey Doerre, David J. Grunwald, Bob Riggleman,
... embryos has the potential to express MyoD when Sonic hedgehog is expressed ubiquitously in the embryo, and that this potential is lost in some of the cells of the paraxial mesoderm lineage in no tail and spadetail embryos. We also show that MyoD ...
Tópico(s): Muscle Physiology and Disorders
1996 - The Company of Biologists | Development
Kyungjoo Cho, Hyuk Moon, Sang Hyun Seo, Simon Weonsang Ro, Beom Kyung Kim,
... a murine model of CCC developed by hydrodynamic tail vein injection method. In the murine model, CCC induced by constitutively active forms of TAZ and PI3K exhibited up-regulated sonic hedgehog signaling. Treatment of vismodegib significantly suppressed tumor development ...
Tópico(s): Cancer-related Molecular Pathways
2021 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Yinxiong Li, Michael J. Farrell, Ruiping Liu, Nita Mohanty, Margaret L. Kirby,
... double-stranded RNA. Expression of the zebrafish genes sonic hedgehog and floating head was altered in the embryos microinjected with the Zf-T double-stranded RNA in a manner that is remarkably similar to the zebrafish no-tail mutant. Microinjection of double-stranded RNA targeted to ...
Tópico(s): Genetics, Aging, and Longevity in Model Organisms
2000 - Elsevier BV | Developmental Biology
Shuhui Zhang, Jia Xu, Xiangyu Kuang, Shibao Li, Xiang Li, Dongyan Chen, Xin Zhao, Xizeng Feng,
... 10 mg/L. The expression of ntl (no tail) shortened and krox20 (also known as Egr2b, early growth response 2b) changed as the glyphosate concentration increased, but there was no change in the expression of shh (sonic hedgehog). In addition, biomechanical analysis of the elasticity of ...
Tópico(s): Environmental Toxicology and Ecotoxicology
2017 - Elsevier BV | Chemosphere
Mohamed Tail, Hao Zhang, Guoli Zheng, Maryam Hatami, Thomas Skutella, Andreas Unterberg, Klaus Zweckberger, Alexander Younsi,
The Sonic Hedgehog protein (Shh) has been extensively researched since its discovery in 1980. Its crucial role in early neurogenesis and endogenous stem cells of mature brains, as well as its recently described neuroprotective features, implicate further important effects on neuronal homeostasis. Here, we investigate its potential role in the survival, proliferation, and differentiation of neural precursors cells (NPCs) under inflammatory stress as a potential adjunct for NPC-transplantation strategies ...
Tópico(s): Head and Neck Surgical Oncology
2022 - Multidisciplinary Digital Publishing Institute | Cells
AIM:To analyze the activation of sonic hedgehog (SHh) signaling pathways in a rat model of chronic pancreatitis.METHODS: Forty Wistar rats were randomly divided into 2 groups: experimental group and control group (20 rats in each group).Dibutyltin dichloride was infused into the tail vein of the rats to induce chronic pancreatitis in the experimental group.The same volume of ethanol and glycerol mixture was infused ...
Tópico(s): Teratomas and Epidermoid Cysts
2014 - Baishideng Publishing Group | World Journal of Gastroenterology
Hao Zhang, Alexander Younsi, Guoli Zheng, Mohamed Tail, Anna-Kathrin Harms, Judith Roth, Maryam Hatami, Thomas Skutella, Andreas Unterberg, Klaus Zweckberger,
Abstract Purpose The Sonic Hedgehog (Shh) pathway has been associated with a protective role after injury to the central nervous system (CNS). We, therefore, investigated the effects of intrathecal Shh-administration in the subacute phase after thoracic spinal cord injury (SCI) on secondary injury processes in rats. Methods Twenty-one Wistar rats were subjected to thoracic clip-contusion/compression SCI at T9. Animals were randomized into three treatment groups (Shh, Vehicle, Sham). Seven days after ...
Tópico(s): Spinal Dysraphism and Malformations
2021 - Springer Science+Business Media | European Spine Journal
Produção Nacional
Revisado por pares
... actinotrichia synthesis during the regenerative process of the tail fin. This could be because naproxen did not influence the expression of the genes required for the regeneration process, such as the Sonic hedgehog (Shh) gene, which is involved in actinotrichia formation.
Tópico(s): Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
2009 - Instituto Internacional de Ecologia (Brazil) | Brazilian Journal of Biology
Chenwei Li, David G. Heidt, Piero Dalerba, Charles Burant, Lanjing Zhang, Volkan Adsay, Max S. Wicha, Michael F. Clarke, Diane M. Simeone,
... form tumors was confirmed in an orthotopic pancreatic tail injection model. The CD44+CD24+ESA+ pancreatic cancer cells showed the stem cell properties of self-renewal, the ability to produce differentiated progeny, and increased expression of the developmental signaling molecule sonic hedgehog. Identification of pancreatic cancer stem cells and further ...
Tópico(s):
2007 - American Association for Cancer Research | Cancer Research
Rodrigo Cuervo, Rocío Hernández-Martínez, Jesús Chimal‐Monroy, Horacio Merchant‐Larios, Luis Covarrubias,
... all developing tetrapod limbs and regenerating amphibian blastema, Sonic hedgehog is expressed in the posterior mesenchyme during fin regeneration. Hedgehog signaling plays a role in the regeneration and patterning processes: an increase or reduction of fin bony elements results when this signaling is activated or disrupted, respectively. The tail fin also regenerates but, in contrast with pectoral ...
Tópico(s): Paleontology and Evolutionary Biology
2012 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Natalia A. Riobo‐Del Galdo, Berangere Saucy, Cherisse DiLizio, David R. Manning,
... of pertussis toxin-inhibited activation of Gli by Sonic hedgehog can be achieved with a constitutively active Galpha(i)-subunit. The data suggest that Smo is in fact the source of two signals relevant to the activation of Gli: one involving G(i) and the other involving events at Smo's C-tail independent of G(i).
Tópico(s): Genomics and Chromatin Dynamics
2006 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Lisa V. Goodrich, Matthew P. Scott,
... L. Tabin C.J. Conservation in hedgehog signaling Sonic hedgehog controls the expression of a chicken patched homolog in the developing limb.Development. 1996; 122 (c): 1225-1233Crossref PubMed Google Scholar). Third, a differentiated notochord does not appear to be required for floor plate formation, since a Shh-expressing floor plate develops in no tail zebrafish mutants, which have notochord precursor cells but ...
Tópico(s): Congenital Ear and Nasal Anomalies
1998 - Cell Press | Neuron
You Li, Yifan Wei, He Li, Hui Che, Dengshun Miao, Cheng Ma, Yongxin Ren,
... degradation of the extracellular matrix (ECM) caused by tail suspension (TS). In addition, inflammation, oxidative stress, and apoptosis levels were significantly increased in the intervertebral disc tissues of TS-induced mice, and the activity of NP cells was decreased. TS also led to the downregulation of Sonic hedgehog (SHH) signalling pathway-related signal molecules in NP ...
Tópico(s): Cervical and Thoracic Myelopathy
2022 - Hindawi Publishing Corporation | Oxidative Medicine and Cellular Longevity
Lia M. Gavazzi, Muraleedharan G. Nair, Robert Suydam, Sharon Usip, J. G. M. Thewissen, Lisa Noelle Cooper,
... drive appendage outgrowth in other vertebrates (e.g., Sonic Hedgehog [SHH], GREMLIN [GREM], wingless‐type family member 7a [WNT], and fibroblast growth factors [FGFs]) and to test the hypothesis that signals associated with outgrowth and patterning of the tail fluke are similar to a tetrapod limb. Specifically, ...
Tópico(s): dental development and anomalies
2024 - Wiley | Developmental Dynamics
Tetsuya Ishikawa, H. Yoshioka, Hideyo Ohuchi, Sumihare Noji, Tsutomu Nohno,
... Xenopus embryos. A secondary body axis expressing the Sonic hedgehog and N-CAM genes is induced by injecting mRNA encoding truncated form of BRK-3 into ventral marginal region, implicating the BMP signaling in axial mesoderm induction. Formation of the secondary axis depends on whether the deletion extends into the kinase domain, not into the carboxy-terminal tail, suggesting that the kinase domain, but not the ...
Tópico(s): Kruppel-like factors research
1995 - Elsevier BV | Biochemical and Biophysical Research Communications
Eduardo Rosa‐Molinar, Anne Campbell Burke,
... appendages such as arthropod and vertebrate limbs, chordate tails and external genitalia are evolutionarily divergent duplicates (paramorphs) of the main body axis. Suzuki's and Podlasek's presentations focused on the development of mammalian genitalia. Suzuki presented Suzuki et al investigations of the role of fibroblast growth factor (Fgf) and Sonic hedgehog (Shh) as signaling molecules during murine external genitalia ...
Tópico(s): Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
2002 - Wiley | Evolution & Development