Francisco Sautua, Sergio González, Vinson P. Doyle, Marcelo F. Berretta, Manuela Gordó, Mercedes Scandiani, Máximo Rivarola, Paula Fernández, Marcelo Carmona,
Cercospora kikuchii (Tak. Matsumoto & Tomoy.) M.W. Gardner 1927 is an ascomycete fungal pathogen that causes Cercospora leaf blight and purple seed ...
Tópico(s): Genomics and Phylogenetic Studies
2019 - Elsevier BV | Data in Brief
Tak Matsumoto, Philip B. Russell, Cesar Mina, William Van Ark, Victor Jay Banta,
An airborne tracking sunphotometer, mounted on the outside top surface of an aircraft has been developed to provide unrestricted viewing of the Sun. This instrument will substantially increase the data that scientists can gather for atmospheric studies. The instrument has six wavelength channels and an automatic data gathering system. The instrument's optical features, tracking capability, mechanical features, and data gathering system are described.
Tópico(s): Solar and Space Plasma Dynamics
1987 - American Meteorological Society | Journal of Atmospheric and Oceanic Technology
Zijia Peng, Chaowei Xiong, Zeyu Luo, Xiangyun Hu, Zhongdong Yu, Tianxiang Chen, Yong Xu, Bin Wang,
... as the alternate host of M. chelidonii-pierotii Tak. Matsumoto, M. coleosporioides Dietel, M. idesiae Miyabe, and M. ...
Tópico(s): Plant Disease Resistance and Genetics
2021 - American Phytopathological Society | Plant Disease
Masaki Akita, Yon-Soo Tak, Tsutomu Shimura, S. Matsumoto, Yuki Okuda-Shimizu, Yuichiro Shimizu, Ryotaro Nishi, Hisato Saitoh, Shigenori Iwai, Toshio Mori, Tsuyoshi Ikura, Wataru Sakai, Fumio Hanaoka, Kaoru Sugasawa,
Abstract The xeroderma pigmentosum group C (XPC) protein complex is a key factor that detects DNA damage and initiates nucleotide excision repair (NER) in mammalian cells. Although biochemical and structural studies have elucidated the interaction of XPC with damaged DNA, the mechanism of its regulation in vivo remains to be understood in more details. Here, we show that the XPC protein undergoes modification by small ubiquitin-related modifier (SUMO) proteins and the lack of this modification compromises ...
Tópico(s): Toxoplasma gondii Research Studies
2015 - Nature Portfolio | Scientific Reports
Antonio Oliveira-dos-Santos, Josef Penninger, Theresa Rieker–Geley, Goichi Matsumoto, Tak M. Mak, Georg Wick,
... for more papers by this authorGoichi Matsumoto, Goichi Matsumoto Amgen Institute and Ontario Cancer Institute, Departments of Medical Biophysics and Immunology, University of Toronto, Toronto, CanadaSearch for more papers by this authorTak M. Mak, Tak M. Mak Amgen Institute and Ontario Cancer Institute, ... for more papers by this authorGoichi Matsumoto, Goichi Matsumoto Amgen Institute and Ontario Cancer Institute, Departments of Medical Biophysics and Immunology, University of Toronto, Toronto, CanadaSearch for more papers by this authorTak M. Mak, Tak M. Mak Amgen Institute and Ontario Cancer Institute, ...
Tópico(s): Immune Cell Function and Interaction
1998 - Wiley | European Journal of Immunology
Jong Sung Park, Daiva Svetkauskaite, Qianbin He, Jae‐Yeol Kim, Derek Strassheim, Akitoshi Ishizaka, Edward Abraham,
... IKKβ[S177A] from Tularik, South San Francisco, CA; TAK-1[K63W] and TAB2[1281–2551] from Dr. Kuni Matsumoto, Nagoya University, Nagoya, Japan; p38α[TGY180–182AGF] from ...
Tópico(s): Neutrophil, Myeloperoxidase and Oxidative Mechanisms
2004 - Elsevier BV | Journal of Biological Chemistry
Masahiro Izumi, Yasushi Fujio, Keita Kunisada, Shinji Negoro, Eiro Tone, Masanobu Funamoto, Tomoaki Osugi, Yuichi Oshima, Yoshikazu Nakaoka, Tadamitsu Kishimoto, Keiko Yamauchi‐Takihara, Hisao Hirota,
... Another pathway is the MAPK cascade initiated by TAK-1 (6Yamaguchi K. Shirakabe K. Shibuya H. Irie K. Oishi I. Ueno N. Taniguchi T. Nishida E. Matsumoto K. Science. 1995; 270: 2008-2011Crossref PubMed Scopus (1172) Google Scholar). TAK-1 was originally identified as a member of ... Scholar). More recently, it has been reported that TAK-1 functions as a mediator of the MKK6/p38 MAPK and MKK7/JNK pathways (7Moriguchi T. Kuroyanagi N. Yamaguchi K. Gotoh Y. Irie K. Kano T. Shirakabe K. Muro Y. Shibuya H. Matsumoto K. Nishida E. Hagiwara M. J. Biol. Chem. ...
Tópico(s): Cardiac Fibrosis and Remodeling
2001 - Elsevier BV | Journal of Biological Chemistry
... Nigeria are the green smut (Ustilaginoidea virens (Cooke) Tak.), basal sheath rot (Rhizoctonia solani Kühn), sheath blight (Corticium sasakii (Shirai), Matsumoto.), leaf scald (Rhynchosporium oryzae Hashioka and Yokogi), narrow ...
Tópico(s): Plant Disease Resistance and Genetics
1974 - Taylor & Francis | PANS Pest Articles & News Summaries
Christopher J. Caunt, Endre Kiss-Tóth, Franço Carlotti, Robert M. Chapman, Eva E. Qwarnström,
... Thus, activation through TRAF6 via TAB-2 and TAK-1 (47Ninomiya-Tsuji J. Kishimoto K. Hiyama A. Inoue J. Cao Z. Matsumoto K. Nature. 1999; 398: 252-256Crossref PubMed Scopus ( ...
Tópico(s): Protein Kinase Regulation and GTPase Signaling
2001 - Elsevier BV | Journal of Biological Chemistry
... new distribution map is provided for Cercospora kikuchii (Tak. Matsumoto & Tomoy.) M.W. Gardner Fungi: Mitosporic fungi: Hyphomycetes ...
Tópico(s): Plant Disease Resistance and Genetics
2006 - | Distribution Maps of Plant Diseases
Jennifer L. Slack, Kenneth Schooley, Timothy P. Bonnert, Jennifer L. Mitcham, Eva E. Qwarnström, John E. Sims, Steven Dower,
... Scholar). TRAF-6 is the upstream regulator of TAK-1 (35.Ninomiya-Tsuji J. Kishimoto K. Hiyama A. Inoue J. Cao Z.D. Matsumoto K. Nature. 1999; 398: 252-256Crossref PubMed Scopus ( ...
Tópico(s): Cytokine Signaling Pathways and Interactions
2000 - Elsevier BV | Journal of Biological Chemistry
Karl Deacon, Jonathan L. Blank,
... Oishi I. Ueno N. Taniguchi T. Nishida E. Matsumoto K. Science. 1995; 270: 2008-2011Crossref PubMed Scopus (1166) Google Scholar). TAK-1 has also recently been shown to activate MKK3 and MKK6 in vitro and in vivo (35Moriguchi T. Kuroyanagi N. Yamaguchi K. Gotoh Y. Irie K. Kano T. Shirakabe K. Muro Y. Shibuya H. Matsumoto K. Nishida E. Hagiwara M. J. Biol. Chem. ...
Tópico(s): Protein Kinase Regulation and GTPase Signaling
1997 - Elsevier BV | Journal of Biological Chemistry
Hiroshi Imoto, Mitsuharu Matsumoto, Hiroyuki Odaka, Junichi Sakamoto, Hiroyuki Kimura, Masami Nonaka, Yutaka Kiyota, Yū Momose,
Preparation and biological activity of the metabolites of the potent antihyperglycemic and antihyperlipidemic agent, (E)-4-{4-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methoxy]benzyloxyimino}-4-phenylbutyric acid (TAK-559) (1), were investigated. Metabolites M-I (2), M-II (3), M-III (4) and M-IV (5) were synthesized and their biological activities were evaluated by in vitro and in vivo experiments. Compounds 2—4 activate human peroxisome proliferator-activated receptor gamma one (hPPARγ1) and hPPARα, but their ...
Tópico(s): Retinoids in leukemia and cellular processes
2004 - Pharmaceutical Society of Japan | Chemical and Pharmaceutical Bulletin
Takashi Sakai, Li Liu, Xichuan Teng, Rika Mukai‐Sakai, Hidenori Shimada, Ryuji Kaji, Tasuku Mitani, Mitsuru Matsumoto, Kazunori Toida, Kazunori Ishimura, Yuji Shishido, Tak W. Mak, Kiyoshi Fukui,
Nucling is a novel protein isolated from murine embryonal carcinoma cells with an up-regulated expression during cardiac muscle differentiation. We show here that Nucling was up-regulated by proapoptotic stimuli and important for the induction of apoptosis after cytotoxic stress. We further demonstrated that overexpressed Nucling was able to induce apoptosis. In Nucling-deficient cells, the expression levels of Apaf-1 and cytochrome c, which are the major components of an apoptosis-promoting complex ...
Tópico(s): Autophagy in Disease and Therapy
2004 - Elsevier BV | Journal of Biological Chemistry
Takehiko Sasaki, Teiji Wada, Hiroyuki Kishimoto, Junko Irie-Sasaki, Goichi Matsumoto, T. Goto, Zhengbin Yao, Andrew Wakeham, Tak W. Mak, Akira Suzuki, Sarah K. Cho, Juan Carlos Zúñiga‐Pflücker, Antonio J. Oliveira-dos-Santos, Toshiaki Katada, Hiroshi Nishina, Josef Penninger,
The dual specificity kinases mitogen-activated protein kinase (MAPK) kinase (MKK)7 and MKK4 are the only molecules known to directly activate the stress kinases stress-activated protein kinases (SAPKs)/c-Jun N-terminal kinases (JNKs) in response to environmental or mitogenic stimuli. To examine the physiological role of MKK7 in hematopoietic cells, we used a gene targeting strategy to mutate MKK7 in murine T and B cells and non-lymphoid mast cells. Loss of MKK7 in thymocytes and mature B cells results ...
Tópico(s): Research on Leishmaniasis Studies
2001 - Rockefeller University Press | The Journal of Experimental Medicine
Yuichiro Miyaoka, Minoru Tanaka, Takahiro Naiki, Atsushi Miyajima,
... PPARγ function through NF-κB activated by the TAK/TAB1/NIK cascade (7Suzawa M. Takada I. Yanagisawa J. Ohtake F. Ogawa S. Yamauchi T. Kadowaki T. Takeuchi Y. Shibuya H. Gotoh Y. Matsumoto K. Kato S. Nat. Cell Biol. 2003; 5: ...
Tópico(s): interferon and immune responses
2006 - Elsevier BV | Journal of Biological Chemistry
Naoki Tarui, Yoichi Nagano, Takeshi Sakane, Kiyoharu Matsumoto, Mitsuru Kawada, Osamu Uchikawa, Shigenori Ohkawa, Kazuo Nakahama,
The chiral indan derivative (S)-2 (2-[(8S)-1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl]ethyl-amine) was synthesized by enzyme-catalyzed asymmetric hydrolysis of the racemic acetamide 1 (N-[2-(1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl)ethyl]acetamide). The reaction was carried out using Bacillus sp. SUI-12 screened for the ability to hydrolyze 1 to give (S)-2 with high enantioselectivity. In a scaled-up experiment, a low reaction rate was observed. However, by changing the culture medium and the ...
Tópico(s): Chemical Reaction Mechanisms
2002 - Elsevier BV | Journal of Bioscience and Bioengineering
Nobuyo Yoshida, Naoki Nishizawa, Hisanori Matsui, Yuu Moriya, Chieko Kitada, Taiji Asami, Hirokazu Matsumoto,
TAK-448 and TAK-683, investigational agents with potential utility in the treatment of prostate cancer, are potent low molecular weight metastin receptor agonists consisting of nine amino acids. Monoclonal antibodies (mAbs) against these agents were developed to facilitate their evaluation in preclinical studies. Six mAbs were obtained from four immunogens. Three mAbs recognized the C-terminal of TAK-683 and TAK-448, two recognized the N-terminal of TAK-683, and one recognized the N-terminal of TAK- ...
Tópico(s): Neuropeptides and Animal Physiology
2012 - Elsevier BV | Journal of Pharmaceutical and Biomedical Analysis
Masamune Kuno, Kayo Nemoto, Norifumi Ninomiya, E. Inagaki, Minoru Kubota, Tatsumi Matsumoto, Hiroyuki Yokota,
1. TAK-242 is a novel compound that suppresses nitric oxide and cytokine production by selectively inhibiting intracellular signals from toll-like receptor (TLR)-4. In the present study, we investigated the effectiveness of TAK-242 against sepsis using an endotoxaemia model in conscious and unrestricted guinea-pigs. Measures examined included muscle tension paralysis of the intestine, blood pressure, high morbidity group box (HMGB)-1 levels and survival rate. 2. Tension of the longitudinal muscle ...
Tópico(s): Pediatric health and respiratory diseases
2009 - Wiley | Clinical and Experimental Pharmacology and Physiology
Kenji Kokura, Hyungtae Kim, Toshie Shinagawa, Md Matiullah Khan, Teruaki Nomura, Shunsuke Ishii,
... an alternative pathway involving TGF-β-activated kinase (TAK-1) and TAK1-binding protein 1 (TAB1) also mediates TGF-β signaling (2Shibuya H. Yamaguchi K. Shirakabe K. Tonegawa A. Gotoh Y. Ueno N. Irie K. Nishida E. Matsumoto K. Science. 1996; 272: 1179-1182Crossref PubMed Scopus ( ...
Tópico(s): Heterotopic Ossification and Related Conditions
2003 - Elsevier BV | Journal of Biological Chemistry
Yasushi Hattori, Shigemitsu Matsumoto, Shinji Morimoto, Masaki Daini, Masashi Toyofuku, Satoru Matsuda, Rina Baba, Koji Murakami, Misa Iwatani, Hideyuki Oki, Shinji Iwasaki, Kouta Matsumiya, Yusuke Tominari, Haruhide Kimura, Mitsuhiro Ito,
Lysine-specific demethylase 1 (LSD1) is an enzyme that demethylates methylated histone H3 lysine 4 (H3K4). Inhibition of LSD1 enzyme activity could increase H3K4 methylation levels and treat diseases associated with epigenetic dysregulation. However, known LSD1 inhibitors disrupt the interaction between LSD1 and cofactors such as GFI1B, causing the risk of hematological toxicity, including thrombocytopenia. Starting from a known LSD1 inhibitor (±)1 as a lead compound, a novel series of LSD1 inhibitors ...
Tópico(s): RNA modifications and cancer
2022 - Elsevier BV | European Journal of Medicinal Chemistry
Yosuke Miyachi, Miki Nishio, Junji Otani, Shinji Matsumoto, Akira Kikuchi, Tak W. Mak, Tomohiko Maehama, Akira Suzuki,
There are currently no treatments for salivary gland diseases, making it vital to understand signaling mechanisms operating in acinar and ductal cells so as to develop regenerative therapies. To date, little work has focused on elucidating the signaling cascades controlling the differentiation of these cell types in adult mammals. To analyze the function of the Hippo-TAZ/YAP1 pathway in adult mouse salivary glands, we generated adMOB1DKO mice in which both MOB1A and MOB1B were TAM-inducibly deleted ...
Tópico(s): Axon Guidance and Neuronal Signaling
2021 - Wiley | Genes to Cells
M. Kimura, Taichi Kato, Keisuke Isogai, Hyungsuk Tak, M. Shidatsu, Hiroshi Itoh, Tamás Tordai, Kiyoshi Kasai, William Goff, S. Kiyota, R. Pickard, Katsura Matsumoto, Naoto Kojiguchi, Yuki Sugiura, Eiji Yamada, Taiki Tatsumi, Atsushi Miyashita, Pavol A. Dubovský, Igor Kudzej, Enrique de Miguel, William Stein, Yoshitomo Maeda, Е. П. Павленко, A. A. Sosnovskij, Julia V. Babina, Lewis M. Cook, Daisaku Nogami,
We present optical multi-colour photometry of V404 Cyg during the outburst from December, 2015 to January, 2016 together with the simultaneous X-ray data. This outburst occurred less than 6 months after the previous outburst in June-July, 2015. These two outbursts in 2015 were of a slow rise and rapid decay-type and showed large-amplitude ($\sim$2 mag) and short-term ($\sim$10 min-3 hours) optical variations even at low luminosity (0.01-0.1$L_{\rm Edd}$). We found correlated optical and X-ray variations ...
Tópico(s): Gamma-ray bursts and supernovae
2017 - Oxford University Press | Monthly Notices of the Royal Astronomical Society
Masaru Iimuro, Masanori Kaneko, Yuji Matsumoto, Yutaka Fujise, Toshifumi Watanabe, Hideharu Hayashi,
The purpose of this study was to investigate the effects of an endothelin-receptor antagonist TAK-044 on functional defects and metabolic derangement in myocardial ischemia/reperfusion injury. We sequentially measured high-energy phosphate metabolites and intracellular pH by phosphorus magnetic resonance spectroscopy during 35-min global ischemia followed by 60-min reperfusion in Langendorff-perfused rat hearts. TAK-044 (initial loading by 3 mg/kg followed by perfusion with 100 nM solution) was administered ...
Tópico(s): Electron Spin Resonance Studies
2000 - Lippincott Williams & Wilkins | Journal of Cardiovascular Pharmacology
Meghali Nighot, Manmeet Rawat, Rana Al–Sadi, Eliseo F. Castillo, Prashant K. Nighot, Y. Thomas,
... Scholar Transforming growth factor-β–activated kinase-1 (TAK-1) has been shown to be a pivotal factor for NF-κB activation in response to the activation of various toll-like receptors, including TLR-2, TLR-4, and TLR-5.39Sato S. Sanjo H. Takeda K. Ninomiya-Tsuji J. Yamamoto M. Kawai T. Matsumoto K. Takeuchi O. Akira S. Essential function for the kinase TAK1 in innate and adaptive immune responses.Nat Immunol. 2005; 6: 1087-1095Crossref PubMed Scopus (759) Google Scholar The phosphorylation of TAK-1 is a common signal for the activation ...
Tópico(s): Helicobacter pylori-related gastroenterology studies
2019 - Elsevier BV | American Journal Of Pathology
Naoki Nishizawa, Yoshihiro Takatsu, Satoshi Kumano, Atsushi Kiba, Junko Ban, Shunichirou Tsutsumi, Hisanori Matsui, Shin-ichi Matsumoto, Masashi Yamaguchi, Yukihiro Ikeda, Masami Kusaka, Tetsuya Ohtaki, Fumio Itoh, Taiji Asami,
Metastin/kisspeptin is an endogenous ligand of KISS1 Receptor (KISS1R). Metastin and KISS1R are suggested to play crucial roles in regulating the secretion of gonadotropin-releasing hormone (GnRH), and continuous administration of metastin derivatives attenuated the plasma testosterone levels in male rats. Our optimization studies of metastin derivatives led to the discovery of 1 (Ac-d-Tyr-d-Trp-Asn-Thr-Phe-azaGly-Leu-Arg(Me)-Trp-NH2, TAK-683), which suppressed plasma testosterone in rats at lower ...
Tópico(s): Hormonal and reproductive studies
2016 - American Chemical Society | Journal of Medicinal Chemistry
Y Sunose, Susumu Ohwada, Izumi Takeyoshi, Koshi Matsumoto, Hirofumi Tsutsumi, Naoki Tomizawa, Susumu Kawate, Y Morishita,
This study investigated the possibility of pharmacologic protection using an endothelin (ET) receptor antagonist, TAK-044 (TAK), for small bowel autograft in a canine controlled non-heart-beating donor (NHBD) model.Sixteen adult mongrel dogs were allocated into 2 groups. TAK (3 mg/kg) (n = 8) was administered intravenously 30 minutes before ischemia and 30 minutes before graft reperfusion. Vehicle was administered in the control (n = 8). The superior mesenteric artery and vein were clamped for 90 minutes ...
Tópico(s): Nitric Oxide and Endothelin Effects
2001 - Elsevier BV | Surgery
Hisanori Matsui, Tsuneo Masaki, Y. Akinaga, Atsushi Kiba, Yoshihiro Takatsu, Daisuke Nakata, Akira Tanaka, Junko Ban, Shin-ichi Matsumoto, Satoshi Kumano, Atsuko Suzuki, Yukihiro Ikeda, Masashi Yamaguchi, Tatsuya Watanabe, Tetsuya Ohtaki, Masami Kusaka,
Kisspeptin/metastin, a hypothalamic peptide, plays a pivotal role in controlling gonadotropin-releasing hormone (GnRH) neurons, and we have shown that continuous subcutaneous administration of kisspeptin analogues suppresses plasma testosterone in male rats. This study examined pharmacologic profiles of investigational kisspeptin analogues, TAK-448 and TAK-683, in male rats. Both analogues showed high receptor-binding affinity and potent and full agonistic activity for rat KISS1R, which were comparable ...
Tópico(s): Ovarian function and disorders
2014 - Elsevier BV | European Journal of Pharmacology
Tohru Kimura, Yuzo Kadokawa, Hisashi Harada, Masahito Matsumoto, Mitsuharu Sato, Yasuo Kashiwazaki, Masahito Tarutani, Rosemary Sok‐Pin Tan, Tomohiro Takasugi, T. Matsuyama, Tak W. Mak, Shigeru Noguchi, Tadatsugu Taniguchi,
Background: Interferons (IFNs) are a class of cytokines which confer cellular resistance against viral infections. Type I (IFN‐α and ‐β) and type II (IFN‐γ) IFNs utilize distinct receptors, the stimulation of which results in the induction of downstream target genes. These target genes usually contain within their promoter region an IFN responsive element, termed ISRE (IFN stimulated response element) which binds a heterotrimeric transcription factor, ISGF3 (IFN‐stimulated gene factor 3) consisting of ...
Tópico(s): RNA regulation and disease
1996 - Wiley | Genes to Cells
Naoko Matsunaga, Noboru Tsuchimori, Tatsumi Matsumoto, Masayuki Ii,
TAK-242 (resatorvid), a small-molecule–specific inhibitor of Toll-like receptor (TLR) 4 signaling, inhibits the production of lipopolysaccharide-induced inflammatory mediators by binding to the intracellular domain of TLR4. Cys747 in TLR4 has been identified previously as the binding site of TAK-242. However, the mechanism by which TAK-242 inhibits TLR4 signaling after binding to TLR4 remains unknown. The present study demonstrated, using coimmunoprecipitation, that TAK-242 interferes with protein- ...
Tópico(s): Neutrophil, Myeloperoxidase and Oxidative Mechanisms
2010 - American Society for Pharmacology and Experimental Therapeutics | Molecular Pharmacology