Shina Horiuchi, Takao Endo, Hideki Shimoji, Hiroaki Takahashi, Masaki Mitsuuchi, Atsushi Yawata, Hiroaki Mita, Mio Yoshida, Yoshiaki Arimura, Hirofumi Sakamoto, Fumio Itoh, Yuji Hinoda, Kohzoh Imai, Kazuaki Sasaki, Masaaki Sato,
Tópico(s): Ovarian cancer diagnosis and treatment
1998 - Springer Science+Business Media | Journal of Gastroenterology
Hideo Imoto, Hiroshi Fukuoka, Shigenori Tsunesawa, H. Horiuchi, Takao Amemiya, Noboru Koga,
Monoclinic Ru(PO3)3 was prepared as the third form of RuP3O9, and the structure was determined by the single-crystal X-ray technique. It contains infinite spiral chains of polyphosphate ions and RuO6 octahedra as found in other C-form metaphosphates. While other C-form metaphosphates have 3-fold superstructures, monoclinic Ru(PO3)3 has a superstructure with an 8-fold b-axis. The space group is P21/a, and the cell parameters are a = 10.578(5) Å, b = 51.154(5) Å, c = 9.394(4) Å, and β = 97.74(4)°. The comparison ...
Tópico(s): Inorganic Chemistry and Materials
1997 - American Chemical Society | Inorganic Chemistry
Kyoko Nozaki, Wen-ge Li Wg, Toshihide Horiuchi, Hidemasa Takaya, Takao Saito, Akifumi Yoshida, Kazuhiko Matsumura, Yasushi Kato, Takashi Imai, Takashi Miura, Hidenori Kumobayashi,
... and Phosphine−PhosphinitesKyoko Nozaki, Wen-ge Li, Toshihide Horiuchi, Hidemasa Takaya, Takao Saito, Akifumi Yoshida, Kazuhiko Matsumura, Yasushi Kato, Takashi ...
Tópico(s): Cyclopropane Reaction Mechanisms
1996 - American Chemical Society | The Journal of Organic Chemistry
Ken Matsuura, Shizuka Kobayashi, Kohtarou Konno, Miwako Yamasaki, Takahiro Horiuchi, Takao Senda, Tomoatsu Hayashi, Kiyotoshi Satoh, Fumiko Arima‐Yoshida, Kei Iwasaki, Lumi Negishi, Naomi Yasui-Shimizu, Kazuyoshi Kohu, Shigenori Kawahara, Yutaka Kirino, Tsutomu Nakamura, Masahiko Watanabe, Tadashi Yamamoto, Toshiya Manabe, Tetsu Akiyama,
Signal-induced proliferation-associated 1 (SIPA1)-like 1 (SIPA1L1; also known as SPAR1) has been proposed to regulate synaptic functions that are important in maintaining normal neuronal activities, such as regulating spine growth and synaptic scaling, as a component of the PSD-95/NMDA-R-complex. However, its physiological role remains poorly understood. Here, we performed expression analyses using super-resolution microscopy (SRM) in mouse brain and demonstrated that SIPA1L1 is mainly localized to ...
Tópico(s): Cellular transport and secretion
2022 - Society for Neuroscience | Journal of Neuroscience
Masatoshi Kobayashi, Mitsuru Ohsugi, Takayoshi Sasako, Motoharu Awazawa, T. Umehara, Aya Iwane, Naoki Kobayashi, Yukiko Okazaki, Naoto Kubota, Ryo Suzuki, Hironori Waki, Keiko Horiuchi, Takao Hamakubo, Tatsuhiko Kodama, Seiichiro Aoe, Kazuyuki Tobe, Takashi Kadowaki, Kohjiro Ueki,
Adipocyte differentiation is regulated by various mechanisms, of which mitotic clonal expansion (MCE) is a key step. Although this process is known to be regulated by cell cycle modulators, the precise mechanism remains unclear. N6-Methyladenosine (m6A) posttranscriptional RNA modification, whose methylation and demethylation are performed by respective enzyme molecules, has recently been suggested to be involved in the regulation of adipogenesis. Here, we show that an RNA N6-adenosine methyltransferase ...
Tópico(s): Cancer-related gene regulation
2018 - Taylor & Francis | Molecular and Cellular Biology
Tatsuya Oshima, Naoki Ohkubo, Iori Fujiwara, Takashi Horiuchi, Takao KOYAMA, Kaoru Ohe, Yoshinari Baba,
Recently, cyclopentyl methyl ether (CPME) has found use as a commercially available solvent for various applications. As CPME shows better properties such as more hydrophobicity, less solublity in water, less volatility, and more stablity compared with typical ethereal solvents, it could be used as a diluent or an extractant in liquid-liquid extraction systems. In the present study, CPME was found to be useful for the extraction of Au(III) in hydrochloric acid media. Extraction of Au(III) increased ...
Tópico(s): Analytical chemistry methods development
2017 - | Solvent Extraction Research and Development Japan
Yosuke Horiuchi, Mariko Horiuchi, Takao Hanawa, Kunimichi Soma,
Photocatalytic activity from the reaction of titanium oxide with ultraviolet light has recently gained much attention. In particular, there is scientific interest in inducing photocatalytic reactions on Ti-Ni alloy, a material widely used in orthodontic applications. However, it is believed that inducing a photocatalytic reaction with an amorphous oxide film on the alloy is a difficult challenge. In this study, therefore, we sought to induce a photocatalytic reaction on Ti-Ni alloy by subjecting ...
Tópico(s): Dental materials and restorations
2007 - Japanese Society for Dental Materials and Devices | Dental Materials Journal
Narumichi Murakami, Naoto Saito, Hiroshi Horiuchi, Takao Okada, Kazutoshi Nozaki, Kunio Takaoka,
To develop a new technology that enhances the regeneration potential of bone and the repair of large intercalated defects in long bone, recombinant human bone morphogenetic protein-2 (BMP-2; 20 microg or 40 microg) was mixed in a polymer gel (poly-lactic acid-polyethyleneglycol block copolymer; PLA-PEG; 200 mg) and incorporated into titanium fiber-mesh cylinders. Three 5-mm cylinders were placed end-to-end to fill a 15-mm defect created in the humeri of adult rabbits and were stabilized by an intramedullary ...
Tópico(s): Dental Implant Techniques and Outcomes
2002 - Wiley | Journal of Biomedical Materials Research
Toshihiko Horiuchi, Takao KONNO,
We developed an on–line experimental system for conducting hybrid experiments in real time. It combines a computer, which conducts vibration simulation and generates a control signal, and a hydraulic actuator, which conducts a vibration experiment driven by the control signal. This system compensates for actuator delay and thus enables experiments to be carried out in real time. We evaluated the stability of the experiments with respect to the mass of the structure under excitation, and we developed ...
Tópico(s): Fault Detection and Control Systems
2001 - Royal Society | Philosophical Transactions of the Royal Society A Mathematical Physical and Engineering Sciences
Daisuke Honma, Osamu Kanno, Jun Watanabe, Junzo Kinoshita, Makoto Hirasawa, Emi Nosaka, Machiko Shiroishi, Takeshi Takizawa, Isao Yasumatsu, Takao Horiuchi, Akira Nakao, Keisuke Suzuki, Tomonori Yamasaki, Katsuyoshi Nakajima, Miho Hayakawa, Takanori Yamazaki, Ajay Singh Yadav, Nobuaki Adachi,
Polycomb repressive complex 2 (PRC2) methylates histone H3 lysine 27 and represses gene expression to regulate cell proliferation and differentiation. Enhancer of zeste homolog 2 (EZH2) or its close homolog EZH1 functions as a catalytic subunit of PRC2, so there are two PRC2 complexes containing either EZH2 or EZH1. Tumorigenic functions of EZH2 and its synthetic lethality with some subunits of SWItch/Sucrose Non-Fermentable (SWI/SNF) chromatin remodeling complexes have been observed. However, little ...
Tópico(s): Cancer-related gene regulation
2017 - Wiley | Cancer Science
Takao Horiuchi, Yasuyuki Takeda, Noriyasu Haginoya, Masaki Miyazaki, Motoko Nagata, Mayumi Kitagawa, Kouichi Akahane, Kouichi Uoto,
The design, synthesis, and evaluation of novel thieno[2,3-d]pyrimidin-4-yl hydrazone analogues as cyclin-dependent kinase 4 (CDK4) inhibitors are described. In continuing our program aim to search for potent CDK4 inhibitors, the introduction of a thiazole group at the hydrazone part has led to marked enhancement of chemical stability. Furthermore, by focusing on the optimization at the C-4′ position of the thiazole ring and the C-6 position of the thieno[2,3-d]pyrimidine moiety, compound 35 has been ...
Tópico(s): Cancer Mechanisms and Therapy
2011 - Pharmaceutical Society of Japan | Chemical and Pharmaceutical Bulletin
Jun‐ichi Kuroyanagi, Kazuo Kanai, Yuuichi Sugimoto, Takao Horiuchi, Issei Achiwa, Hiroshi Takeshita, Katsuhiro Kawakami,
Synthesis and in vitro antifungal evaluations of 1,3-benzoxazole-7-carbonitrile 3, 1,3-benzoxazole-4-carbonitrile 4, benzofuran 5, benzoxazine 7, and benzimidazole 8 were reported. Among them, 1,3-benzoxazole-4-carbonitrile was found to be a superior scaffold structure with moderate growth inhibition against Candida species. 1,3-Benzoxazole-4-carbonitrile 6 showed potent activity against Candida species compared to 5-desmethyl compound 4 and triazolopyridine 2. Compound 6 was efficiently prepared ...
Tópico(s): Synthesis and biological activity
2010 - Elsevier BV | Bioorganic & Medicinal Chemistry
Takao Horiuchi, Motoko Nagata, Mayumi Kitagawa, Kouichi Akahane, Kouichi Uoto,
The design, synthesis and evaluation of novel thieno[2,3-d]pyrimidin-4-yl hydrazone analogues as cyclin-dependent kinase 4 (CDK4) inhibitor are described. Focusing on the optimization of the heteroaryl moiety at the hydrazone with substituted phenyl groups, 4-[(methylamino)methyl]benzaldehyde (22) and 5-isoindolinecarbaldehyde (24) (6-tert-butylthieno[2,3-d]pyrimidin-4-yl)hydrazone derivatives have been identified. In this paper, the potency, selectivity profile and structure-activity relationships ...
Tópico(s): Chronic Lymphocytic Leukemia Research
2009 - Elsevier BV | Bioorganic & Medicinal Chemistry
Michinori Honma, Takao Horiuchi, Toshiaki Nose,
A unique light-emitting liquid-crystal (LC) cell that emits polarized light is developed by an electrochemiluminescent (ECL) method; sandwich-type LC cells filled with a nematic LC doped with an organic fluorescent dye are constructed. Luminance and current density characteristics as a function of an applied voltage are investigated under different sample preparation conditions such as mixing temperature and time. It is shown that luminance strongly depends on the abovementioned conditions. From the ...
Tópico(s): Conducting polymers and applications
2009 - American Institute of Physics | Journal of Applied Physics
Takao Horiuchi, Jun Chiba, Kouichi Uoto, Tsunehiko Soga,
The synthesis and evaluation of new analogues of thieno[2,3-d]pyrimidin-4-yl hydrazones are described. 2-Pyrdinecarboxaldehyde [6-(tert-butyl)thieno[2,3-d]pyrimidine-4-yl]hydrazone derivatives have been identified as cyclin-dependent kinase 4 (CDK4) inhibitors. The potency, selectivity profile, and structure-activity relationship of this series of compounds are discussed.
Tópico(s): Synthesis and Reactivity of Heterocycles
2008 - Elsevier BV | Bioorganic & Medicinal Chemistry Letters
Jun Chiba, Shin Iimura, Yoshiyuki Yoneda, Yuichi Sugimoto, Takao Horiuchi, Fumito Muro, Yuichi Ochiai, Tomomi Ogasawara, Masao Tsubokawa, Yutaka Iigou, Gensuke Takayama, Tomoe Taira, Yoshimi Takata, Mika Yokoyama, Tohru Takashi, Atsushi Nakayama, Nobuo Machinaga,
A novel series of benzoic acid derivatives as VLA-4 antagonists were synthesized. Optimization, focusing on activity and lipophilicity needed for cell permeability, resulted in the identification of 15b and 15e with good activity (IC50 = 1.6 nM each) and moderate lipophilicity (Log D = 2.0, 1.8). Furthermore, 15e demonstrated efficacy in murine asthma model by an oral dose of 30 mg/kg.
Tópico(s): Neuropeptides and Animal Physiology
2006 - Pharmaceutical Society of Japan | Chemical and Pharmaceutical Bulletin
Kousuke Kimura, Satoshi Hata, Syo Matsumura, Takao Horiuchi,
Here we show a technique to obtain a tilt series of dark-field (DF) transmission electron microscopy (TEM) images in ordering alloys for tomographic three-dimensional (3D) observations. A tilt series of DF TEM images of D1a-ordered Ni4Mo precipitates in a Ni-Mo alloy was successfully obtained by adjusting a diffraction condition for a superlattice reflection from the Ni4Mo precipitates. Since the superlattice reflection usually has a long extinction distance, dynamic diffraction effects such as thickness ...
Tópico(s): Integrated Circuits and Semiconductor Failure Analysis
2005 - Oxford University Press | Microscopy
Yasuyuki Takeda, Kouichi Uoto, Jun Chiba, Takao Horiuchi, Michio Iwahana, Ryo Atsumi, Chiho Ono, Hirofumi Terasawa, Tsunehiko Soga,
It was shown that a new taxane analogue 3, which exhibited both in vitro antitumor activity and in vivo efficacy by both i.v. and p.o. administration, was prone to be metabolized by human liver microsomes. We identified a major metabolite, M-1, generated by human liver microsomes as 20a, a hydroxylated compound at the pyridine ring of 3. To improve the metabolic stability of 3, we designed and synthesized new taxane analogues based on the structure of M-1, and obtained some compounds that maintained ...
Tópico(s): Microbial Natural Products and Biosynthesis
2003 - Elsevier BV | Bioorganic & Medicinal Chemistry
Hiroaki Hemmi, Tsuneyasu Kaisho, Osamu Takeuchi, Shintaro Sato, Hideki Sanjo, Katsuaki Hoshino, Takao Horiuchi, Hideyuki Tomizawa, Kiyoshi Takeda, Shizuo Akira,
Tópico(s): Immunotherapy and Immune Responses
2002 - Nature Portfolio | Nature Immunology
Osamu Takeuchi, Shintaro Sato, Takao Horiuchi, Katsuaki Hoshino, Kiyoshi Takeda, Zhongyun Dong, Robert L. Modlin, Shizuo Akira,
Abstract The Toll-like receptor (TLR) family acts as pattern recognition receptors for pathogen-specific molecular patterns (PAMPs). TLR2 is essential for the signaling of a variety of PAMPs, including bacterial lipoprotein/lipopeptides, peptidoglycan, and GPI anchors. TLR6 associates with TLR2 and recognizes diacylated mycoplasmal lipopeptide along with TLR2. We report here that TLR1 associates with TLR2 and recognizes the native mycobacterial 19-kDa lipoprotein along with TLR2. Macrophages from ...
Tópico(s): Neonatal and Maternal Infections
2002 - American Association of Immunologists | The Journal of Immunology
Takao Horiuchi, Toshifumi� Ohkusa, Mamoru Watanabe, Daisuke Kobayashi, Hiroto Miwa, Yoshinobu Eishi,
Helicobacter pylori has been detected in drinking water in Peru and Sweden, suggesting the possibility of water-borne transmission. To date there have been few reports of H. pylori being detected in water; one was of the ureA gene of H. pylori in wells and springs in rural Japan. We examined water sampled in or near urban areas of Japan for H. pylori DNA by three assays using the polymerase chain reaction (PCR). Near Tokyo, samples were obtained: 10 of tap water, 6 of well water, 10 of river water, ...
Tópico(s): Mycobacterium research and diagnosis
2001 - Wiley | Microbiology and Immunology
S. Kohjiya, Takao Horiuchi, Kazuhiro Miura, Motoki KITAGAWA, Tatsuo Sakashita, Yasuo Matoba, Yuko Ikeda,
High molecular mass copolymers (P(EH/EO)s) were synthesized by coordination anionic polymerization of ethylene oxide (EO) and epichlorohydrin (EH), and P(EH/EO)s were used for the preparation of the ion-conducting matrix. The copolymers having EO unit contents of less than 63 mol% were amorphous, and subjected to the complexation with lithium perchlorate. The temperature dependence of ionic conductivity of the P(EH/EO)/LiClO4 complexes was expressed by the Williams–Landel–Ferry equation. Optimal conductivity ...
Tópico(s): Ionic liquids properties and applications
2000 - Wiley | Polymer International
Manabu Koide, Takao Horiuchi, Takashi Inushima, B.J Lee, Mitsuru TOBAYAMA, Hideomi Koinuma,
Based on our previous studies on a cold plasma torch which can generate homogenous and stable plasma under atmospheric pressure, we have developed a new plasma generator to give a lower gas temperature and wider processing area. Instead of the insulator-covered anode in the previous torch, an aluminum cathode with anodically oxidized alumina worked to generate a stable plasma in helium gas flow under atmospheric pressure by the application of rf (13.56 MHz) power between the cathode and a grounded ...
Tópico(s): Plasma Applications and Diagnostics
1998 - Elsevier BV | Thin Solid Films
Shinji Suzuki, Toshifumi Ohkusa, Kengo Shimoi, Takao Horiuchi, Kazuhiko Fujiki, Ichizen Takashimizu,
We previously investigated the relationship between Helicobacter pylori infection and gastric polyps and have found that H. pylori infection was closely associated with the formation of hyperplastic foveolar polyps.1 This relationship is supported by two case reports of Veereman2 and Mocek3 and their associates, who found that the clearance and eradication of H. pylori led to the disappearance of hyperplastic foveolar polyps. However, these studies did not provide information on the changes in endoscopic ...
Tópico(s): Gastrointestinal disorders and treatments
1997 - Elsevier BV | Gastrointestinal Endoscopy
Toshifumi� Ohkusa, Ichizen Takashimizu, Kazuhiko Fujiki, Akihiro Araki, Kimio Honda, Kengo Shimoi, Toshiaki Sakurazawa, Takao Horiuchi, Shinji Suzuki, Kouichiro Ariake, Kenichi Ishii,
There are no studies of changes in immunoglobulin G (IgG) titers to Helicobacter pylori, serum pepsinogen, and gastrin in patients with H. pylori-positive gastric ulcers. We investigated the effect of therapy for H. pylori-positive gastric ulcer on IgG titers to H. pylori, serum pepsinogen I and II, and gastrin. Thirty-six patients with H. pylori-positive gastric ulcer were treated with lansoprazole and antibiotics for 2 weeks. Serum pepsinogen I and II concentrations, serum gastrin, and IgG titers ...
Tópico(s): Galectins and Cancer Biology
1997 - Lippincott Williams & Wilkins | Journal of Clinical Gastroenterology
Bong-ju Lee, Yukihiro Kusano, Nobuko Kato, Kazuo Naito, Takao Horiuchi, Hideomi Koinuma Hideomi Koinuma,
A new application of the atmospheric cold plasma torch has been investigated. Namely, the surface treatment of an air-exposed vulcanized rubber compound. The effect of plasma treatment was evaluated by the bondability of the treated rubber compound with another rubber compound using a polyurethane adhesive. The adhesion property was improved by treatment of the rubber compound with plasma containing oxygen radicals. Physical and chemical changes of the rubber surface as a result of the plasma treatment ...
Tópico(s): Surface Modification and Superhydrophobicity
1997 - Institute of Physics | Japanese Journal of Applied Physics
Hideomi Koinuma, Takao Horiuchi, Kiyoto Inomata, Heon‐Cheol Ha, Kiyotaka Nakajima, Khaliq A. Chaudhary,
Abstract
Tópico(s): Fullerene Chemistry and Applications
1996 - International Union of Pure and Applied Chemistry | Pure and Applied Chemistry
Hye Jin HA, Bum Ki Moon, Takao Horiuchi, Takashi Inushima, Hiroshi Ishiwara, Hideomi Koinuma,
A torch-like plasma generator we developed to make low temperature material processing possible in open air conditions was employed lor the deposition of TiO2 films on substrates exposed to air. Ti(OEt)4 or Ti(O-iPr)4 vapor was fed into the plasma generated in an insulator nozzle lining the inner surface of a grounded cylindrical anode and containing a metal needle cathode at the center. The homogeneous plasma with Tc of 1.8 eV and Tg of 2()0 °C. respectively, could decompose Ti(OR)4 to flush decomposition ...
Tópico(s): Plasma Diagnostics and Applications
1996 - Elsevier BV | Materials Science and Engineering B
Shinzo Kohjiya, Takao Horiuchi, Shinzo Yamashita,
The homopolymer of epichlorohydrin (CHR) and copolymers with ethylene oxide (EO) were investigated as ion-conducting matrix. EO contents in the copolymers were 0, 24, 48, and 63 mol%. When doped with LiClO4, the conductivities were ca 10−6 S cm−1. Mixing with oligo(EO) increased them to 10−5 S cm−1. To obtain single ionic conductors, two polyelectrolytes carrying Li or Na were synthesized from oligo(EO), and mixed to the polymers. The transference numbers were found to be 0.97, while that of the polymer ...
Tópico(s): Synthesis and properties of polymers
1992 - Elsevier BV | Electrochimica Acta
S. Yoshizawa, Takao Horiuchi, Masami Suganuma, Shinji Nishiwaki, Jun Yatsunami, Sachiko Okabe, T. Okuda, Y Muto, Krystyna Frenkel, Walter Troll, Hirota Fujiki,
Penta-O-galloyl-β-D-glucose (5GG), obtained by methanolysis of tannic acid and (-)-epigallocatechin gallate (EGCG), the main constituent of Japanese green tea, were polyphenols which strongly inhibited the specific 3H-12-O-tetradecanoylphorbol-13-acetate (TPA) binding to the phorbol ester receptors in a particulate fraction of mouse skin. Based on the evidence, these polyphenols were thought to inhibit tumor promotion of TPA on mouse skin. 5GG and EGCG inhibited tumor promotion of teleocidin, one of the ...
Tópico(s): Phytoestrogen effects and research
1992 - American Chemical Society | ACS symposium series