Hideko Nakahara, Yosuke Kamide, Yoshimasa Hamano, Takashi Hosokawa, Masayuki Nishide, Yu Lin, Keisuke Kawamoto, Mie Fusama, Shinji Higa, Takashi Kuroiwa, Tsuyoshi Igarashi, Taro Kuritani, Keiji Maeda,
... this author on: Oxford Academic Google Scholar Takashi Hosokawa, Takashi Hosokawa Division of Allergy, Rheumatology and Connective Tissue Diseases, ...
Tópico(s): Tuberculosis Research and Epidemiology
2011 - Oxford University Press | Modern Rheumatology
... the Trapezium: Case ReportHiromi Koshi, Tetsuya Shinozaki, Takafumi Hosokawa, Takashi Yanagawa and Kenji Takagishi1 Mar 2011 | The Journal ...
Tópico(s): Musculoskeletal synovial abnormalities and treatments
2000 - World Scientific | Hand Surgery
Shigemasa Sawada, Susumu Sugai, Shingo Iijima, Masami Takei, Ernesto Paredes, Takashi Hayama, Susumu Nishinarita, Yoshifumi Hosokawa, Takashi Horie, Takashi Obara,
A new enzyme-linked immunosorbent assay for soluble CD4 (sCD4) and soluble CD8 (sCD8) molecules has been developed. We estimated the concentrations of these molecules in patients with Sjögren's syndrome and in patients with systemic lupus erythematosus (SLE) serving as a control population for non-Sjögren's inflammatory disease, since several findings suggestive of an aberration of immunocompetent cells have been reported in these autoimmune diseases.The study population consisted of 41 patients with ...
Tópico(s): Monoclonal and Polyclonal Antibodies Research
1992 - Elsevier BV | The American Journal of Medicine
Yuri Hosokawa, Takashi Nagata, Manabu Hasegawa,
Tokyo 2020 Summer Olympics are projected to experience environmental heat stress that surpasses the environmental conditions observed in the Atlanta (1996), Athens (2004), Beijing (2008), and Rio (2016) Summer Olympics. This raises particular concerns for athletes who will likely to be exposed to extreme heat during the competitions. Therefore, in mass-participation event during warm season, it is vital for the hosting organization to build preparedness and resilience against heat, including appropriate ...
Tópico(s): Exercise and Physiological Responses
2019 - Frontiers Media | Frontiers in Physiology
Tomoko Tanaka, Shinobu Hirai, Masato Hosokawa, Takashi Saito, Hiroshi Sakuma, Takaomi C. Saido, Masato Hasegawa, Haruo Okado,
Alzheimer's disease (AD), a progressive neurodegenerative disorder, is a major societal, scientific, and economic problem. Several early-life factors associated with an increased risk for the clinical diagnosis of AD have recently been identified. In the present study, we investigated the involvement of early-life stress in the pathogenesis of AD using heterozygous amyloid precursor protein (APP) mutant mice (App
Tópico(s): Neurological Disorders and Treatments
2020 - Elsevier BV | Experimental Neurology
Kaoru Tsuchiya, Yasuhiro Asahina, Shuya Matsuda, Masaru Muraoka, Toru Nakata, Yuichiro Suzuki, Nobuharu Tamaki, Yutaka Yasui, Shōko Suzuki, Takanori Hosokawa, Takashi Nishimura, Ken Ueda, Teiji Kuzuya, Hiroyuki Nakanishi, Jun Itakura, Yuka Takahashi, Masayuki Kurosaki, Nobuyuki Enomoto, Namiki Izumi,
BACKGROUND A new predictive biomarker for determining prognosis in patients with hepatocellular carcinoma (HCC) who receive sorafenib is required, because achieving a reduction in tumor size with sorafenib is rare, even in patients who have a favorable prognosis. Vascular endothelial growth factor (VEGF) receptor is a sorafenib target. In the current study, the authors examined changes in plasma VEGF concentrations during sorafenib treatment and determined the clinical significance of VEGF as a prognostic ...
Tópico(s): Angiogenesis and VEGF in Cancer
2013 - Wiley | Cancer
Nobuharu Tamaki, Masayuki Kurosaki, Shuya Matsuda, Toru Nakata, Masaru Muraoka, Yuichiro Suzuki, Yutaka Yasui, Shōko Suzuki, Takanori Hosokawa, Takashi Nishimura, Ken Ueda, Kaoru Tsuchiya, Hiroyuki Nakanishi, Jun Itakura, Yuka Takahashi, Kotaro Matsunaga, Kazuhiro Taki, Yasuhiro Asahina, Namiki Izumi,
Real-time tissue elastography (RTE) is a non-invasive method for the measurement of tissue elasticity using ultrasonography. Liver fibrosis (LF) index is a quantitative method for evaluation of liver fibrosis calculated by RTE image features. This study aimed to investigate the significance of LF index for predicting liver fibrosis in chronic hepatitis C patients.In this prospective study, 115 patients with chronic hepatitis C who underwent liver biopsy were included, and the diagnostic accuracy of ...
Tópico(s): Hepatitis C virus research
2013 - Wiley | Hepatology Research
Seiji Hosokawa, Kunihiro Mizuta, Goro Takahashi, Jun Okamura, Yoshinori Takizawa, Kumiko Hosokawa, Takashi Yamatodani, Hiroyuki Mineta,
Treatment outcomes for carcinomas of the external auditory canal (EAC) were evaluated regarding radiologic and pathologic factors.Retrospective case review.University hospital.Fifteen patients histologically diagnosed with carcinomas of the EAC.A radiologic and pathologic analysis was performed on these patients histologically diagnosed with carcinomas of the EAC and treated surgically at our institution. We evaluated the size of focal defects in the anteroinferior (AI) canal wall of the tympanic ...
Tópico(s): Ear Surgery and Otitis Media
2012 - Lippincott Williams & Wilkins | Otology & Neurotology
Tadashi Nakanishi, K. Mukai, Hiromichi Yumoto, Kouji Hirao, Yoshitaka Hosokawa, Takashi Matsuo,
Nakanishi T, Mukai K, Yumoto H, Hirao K, Hosokawa Y, Matsuo T. Anti‐inflammatory effect of catechin on cultured human dental pulp cells affected by bacteria‐derived factors. Eur J Oral Sci 2010; 118: 145–150. © 2010 The Authors. Journal compilation © 2010 Eur J Oral Sci Catechins (bioactive polyphenols in green tea) are known to exhibit potent anti‐inflammatory properties. However, the anti‐inflammatory effects of catechins on inflamed dental pulp tissue are not known. In this study, we investigated ...
Tópico(s): Bioactive Compounds and Antitumor Agents
2010 - Wiley | European Journal Of Oral Sciences
Hirokazu Okawa, Tomonao Saito, Ryota Hosokawa, Takashi Nakamura, Youhei Kawamura, Katsuyasu Sugawara,
Low (28 kHz) and high (200 kHz) frequency sonication combined with hot water treatments at 45 and 75 °C were investigated to assess the effects of different ultrasound frequencies and water temperatures on the extraction of bitumen from oil sand. A mechanical stirrer was also used to compare the efficiency of separation. Bitumen extraction tests were performed under argon, air, and nitrogen atmospheres. Sonication at 200 kHz was shown to extract bitumen effectively from oil sand at 75 °C. The bitumen ...
Tópico(s): Drilling and Well Engineering
2010 - Institute of Physics | Japanese Journal of Applied Physics
Akira Hosokawa, Takashi UEDA, Ryusuke Onishi, Ryutaro Tanaka, Tatsuaki FURUMOTO,
Tópico(s): Advanced Machining and Optimization Techniques
2010 - Elsevier BV | CIRP Annals
Shinichiro Chuma, Mihoko Hosokawa, Takashi Tanaka, Norio Nakatsuji,
Germline cells of many animals possess characteristic cytoplasmic structures termed germinal granules or nuage. Germinal granules are ribonucleoprotein (RNP) amorphous aggregates lacking limiting membranes, and their molecular composition is evolutionarily conserved in divergent species. Studies on germinal granules in several model animals, such as Drosophila, C. elegans and Xenopus, have mainly focused on the asymmetric partitioning of the structures to prospective germ cells during early embryogenesis. ...
Tópico(s): Genomics and Chromatin Dynamics
2008 - Elsevier BV | Molecular and Cellular Endocrinology
Takayuki Ishida, Keisuke Hosokawa, Takashi Shibata, Shin Suzuki, Н. Нишитани, T. Ogawa,
The propagation parameters of daytime medium‐scale traveling ionospheric disturbances (MSTIDs) are investigated for the first time using near‐simultaneous SuperDARN radar data obtained at auroral and middle latitudes. The observations suggest that MSTIDs can propagate from auroral to mid‐latitudes with persistent propagation parameters if the dominant propagation direction is approximately equatorward. However, statistical analysis implies that a portion of MSTIDs with higher horizontal phase velocity ...
Tópico(s): Earthquake Detection and Analysis
2008 - American Geophysical Union | Geophysical Research Letters
Koichi Takaki, Masato Hosokawa, Takashi Sasaki, Seiji Mukaigawa, T. Fujiwara,
An atmospheric pressure glow discharge was generated using a needle-array electrode in nitrogen, and the voltage–current characteristics of the glow discharge were obtained in a range from 1 mA to 60 A. A pulsed high voltage with short rise time under 10 ns was employed to generate streamer discharges simultaneously at all needle tips. The large number of streamer discharges prevented the glow-to-arc transition caused by inhomogeneous thermalization. Semiconductor opening switch diodes were employed ...
Tópico(s): Electrohydrodynamics and Fluid Dynamics
2005 - American Institute of Physics | Applied Physics Letters
Meishoku Masahara, Yongxun Liu, S. Hosokawa, Takashi Matsukawa, K. Ishii, H. Tanoue, Kunihiro Sakamoto, T. Sekigawa, H. Yamauchi, S. Kanemaru, E. Suzuki,
A vertical ultrathin channel formation process for a vertical type double-gate (DG) MOSFET is proposed. Si wet etching using an alkaline solution has newly been found to be significantly retarded by introducing ion bombardment damage. We have also found that the ion-bombardment-retarded etching (IBRE) is independent of ion species and the implanted impurities can easily be transferred to be the dopants for source and drain regions of MOSFETs. By utilizing the IBRE, vertical type DG MOSFETs with a ...
Tópico(s): Integrated Circuits and Semiconductor Failure Analysis
2004 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Electron Devices
Meishoku Masahara, Shinichi Hosokawa, Takashi Matsukawa, Kazuhiko Endo, Yuuichi Naitou, H. Tanoue, Eiichi Suzuki,
Nanometer-scale dopant profiling in the vertical ultrathin channels (UTCs) of double-gate metal–oxide–semiconductor field-effect transistors has been performed by using scanning nonlinear dielectric microscopy. UTCs 18–58nm thick and 175nm high were formed on a bulk silicon substrate by orientation-dependent wet etching. An n+∕p junction was fabricated on the top of the UTC by angled ion implantation. By beveling the UTC with an ultragentle angle, the vertical size of the UTC was amplified by a factor ...
Tópico(s): Nanowire Synthesis and Applications
2004 - American Institute of Physics | Applied Physics Letters
Seijiro Hosokawa, Takashi Ogura, Hidetaka Togashi, Kuniaki Tatsuta,
Trichostatin D and 6-epi-trichostatin D have been stereoselectively synthesized through a remote stereoinduction with a chiral vinylketene silyl N,O-acetal and glycosylation of hydroxyimide under Mitsunobu conditions.
Tópico(s): 14-3-3 protein interactions
2004 - Elsevier BV | Tetrahedron Letters
Hiroshi Kitagawa, Masashi Hosokawa, Takashi Takeuchi, Toshifumi Yokoyama, Tomohiro Imagawa, Masato Uehara,
To clarify the cellular origin and the fate of M cells, detailed distributions of the epithelial cells were investigated scanning electron microscopically on the follicle-associated epithelia (FAE) of chicken cecal tonsils. The distribution of M cells was closely related with the situation of the crypt orifices in chicken cecal tonsils. In undeveloped cecal tonsils, the intestinal crypts were localized at the periphery of the FAE. In these tonsils, M cells without microvilli (M0) were predominantly ...
Tópico(s): Probiotics and Fermented Foods
2003 - Japanese Society of Veterinary Science | Journal of Veterinary Medical Science
Mahfudz Al Huda, Keiji Yamada, Akira Hosokawa, Takashi UEDA,
A technique for measuring temperature at the interface between a cutting tool and a chip is developed. A two-color pyrometer with fused fiber coupler is applied to the temperature measurement of the tool-chip interface in dry and wet turning. By using this pyrometer, it is possible to measure the temperature of a very small object without emissivity affecting the results. A translucent alumina sintered under HIP is used as the cutting tool, and an annealed carbon steel AISI 1045 is used as the workpiece. ...
Tópico(s): Advanced Sensor Technologies Research
2002 - ASM International | Journal of Manufacturing Science and Engineering
Yasuki Kamai, Mikie Kubota, Yoko Kamai, Tsunemichi Hosokawa, Takashi Fukuoka, Scott G. Filler,
ABSTRACT We investigated the contribution of Candida albicans ALS1 , which encodes a candidal adhesin, to the pathogenesis of experimental murine oropharyngeal candidiasis. Our results indicate that the ALS1 gene product is important for the adherence of the organism to the oral mucosa during the early stage of the infection.
Tópico(s): Infections and bacterial resistance
2002 - American Society for Microbiology | Infection and Immunity
Yasuki Kamai, Mikie Kubota, Yoko Kamai, Tsunemichi Hosokawa, Takashi Fukuoka, Scott G. Filler,
We established a straightforward murine model of oropharyngeal candidiasis. Mice were immunosuppressed with cortisone acetate, anesthetized, and then inoculated by placing cotton wool balls saturated with Candida albicans sublingually for 2 h. A prolonged, reproducible infection was induced. This model may be useful for antifungal screening or pathogenesis studies.
Tópico(s): Fungal Infections and Studies
2001 - American Society for Microbiology | Antimicrobial Agents and Chemotherapy
Katsushige Abe, Yoshiyuki Ozono, Masanobu Miyazaki, Takehiko Koji, Kei Shioshita, Akira Furusu, Shoko Tsukasaki, Fukuzo Matsuya, Nobuko Hosokawa, Takashi Harada, Takashi Taguchi, Kazuhiro Nagata, Shigeru Kohno,
Background. Tubulointerstitial inflammation and fibrosis are the main pathological features of chronic renal allograft rejection, which is characterized by accumulation of extracellular matrix protein. Heat shock protein 47 (HSP47), known as a collagen-specific stress protein, is thought to be a molecular chaperone during the processing and/or secretion of procollagen. HSP47 is thought to be involved in the progression of fibrosis, but its expression in chronic renal allograft rejection is still ...
Tópico(s): Organ Transplantation Techniques and Outcomes
2000 - Oxford University Press | Nephrology Dialysis Transplantation
Takeshi Matsuo, S Okamoto, Yukiko Izumi, A Hosokawa, Takashi TAKEGAWA, Hiroshi Fukui, Zaw Myo Tun, Kazuhiro Honda, Ryo Matoba, Koichi Tatsumi, Nobuyuki Amino,
Abstract Objective Kallmann syndrome is defined by the association of hypogonadotropic hypogonadism and anosmia. The KAL1 gene is responsible for the X-linked form of Kallmann syndrome. In this study we describe monozygotic twins with Kallmann syndrome due to the same mutation in the KAL1 gene. Design We studied male monozygotic twins with Kallmann syndrome. Methods We analyzed the KAL1 gene using the PCR-direct sequencing method. The twins' mother was examined for the identified mutation. Results ...
Tópico(s): Neuropeptides and Animal Physiology
2000 - Oxford University Press | European Journal of Endocrinology
Junko Ogawa, Sayaka Takahashi, Toshihiko Fujiwara, Junichiro Fukushige, Tsunemichi Hosokawa, Takashi Izumi, Shinichi Kurakata, Hiroyoshi Horikoshi,
Recent investigations suggest that cytotoxic cytokines such as tumor necrosis factor (TNF)α and interleukin (IL)-1β or free radicals play an essential role in destruction of pancreatic β cells in Type 1 diabetes and that, therefore, anti-oxidant or anti-TNFα and IL-1β therapy could prevent the development of Type I diabetes. Troglitazone belongs to a novel class of antidiabetic agent possessing the ability to enhance insulin action provably through activating PPAR γ and to scavenge free radicals. ...
Tópico(s): Diet, Metabolism, and Disease
1999 - Elsevier BV | Life Sciences
Kazunori Aoki, Teruhiko Yoshida, Nobuyuki Matsumoto, Hisamitsu Ide, Koichi Hosokawa, Takashi Sügimura, Masaaki Terada,
Peritoneal dissemination is one of the most common complications of the malignancies of the digestive system, such as gastric or pancreatic cancers. Yet, no effective therapy has been established so far to alleviate this devastating and often fatal end-stage condition. Here we describe a novel approach of intraperitoneal (i.p.) lipofection of a suicidal gene to the pancreatic cancer cells in a mouse peritoneal dissemination model. A human pancreatic cancer cell line, PSN-1, was inoculated into the ...
Tópico(s): Renal and related cancers
1997 - Mary Ann Liebert, Inc. | Human Gene Therapy
Kazuo Hirata, Naokichi Hosokawa, Takashi Hase, Toshiyuki Sakuma, Yoichi Miyasaka,
Ferroelectric lead zirconate-titanate (PZT) thin films have been prepared on Pt-coated oxidized Si substrates (Pt/Ti/SiO 2 /Si) utilizing a multitarget magnetron sputtering system with three Pb(Zr 0.5 , Ti 0.5 )O 3 targets and one PbO target. Crystal structure and dielectric properties of the films have been studied as functions of substrate temperature ( T s ) and Pb content. The Pb content in the film has been precisely controlled by optimizing the rf input power for the PbO target ( P PbO ). As a result, single- ...
Tópico(s): Microwave Dielectric Ceramics Synthesis
1992 - Institute of Physics | Japanese Journal of Applied Physics
Yasuo Inubushi, Yoshisuke Tsuda, Hisashi Ishii, Takehiro Sano, Mariko Hosokawa, Takashi Harayama,
Examinations were made on the components of Lycopodium serratum THUNB. var. thunbergii MAKINO (Japanese name Hosoba-Togeshiba) from Mt. Hira in Shiga Prefecture. A new triterpene was isolated from the neutral fraction and named serratendiol, C30H48(OH)2, m.p. 300° (diacetate, m.p. 336-338°, [α]D29+18.8°(c=2.34, CHCl3)), with serratenediol monoacetate, C30H48(OH)OCOCH3, m.p. 319-320°, [α]D10-5.7°(c=1.06, CHCl3).New alkaloids were isolated from the basic fraction and named serratinine, m.p. 244-245°, [ ...
Tópico(s): Fern and Epiphyte Biology
1964 - Pharmaceutical Society of Japan | YAKUGAKU ZASSHI
Reina Hoshi, Shuichiro Uehara, Takashi Hosokawa, Hide Kaneda, Tsugumichi Koshinaga,
... ac.jpSearch for more papers by this authorTakashi Hosokawa, Takashi Hosokawa Department of Pediatric Surgery, Nihon University School ... ac.jpSearch for more papers by this authorTakashi Hosokawa, Takashi Hosokawa Department of Pediatric Surgery, Nihon University School of ...
Tópico(s): Congenital Diaphragmatic Hernia Studies
2022 - Wiley | Pediatrics International
Sunmyon Chon, Takashi Hosokawa, Kazuyuki Omukai, Raffaella Schneider,
ABSTRACT The stellar initial mass function (IMF) in the early universe is essential to understand the formation of ancient galaxies. To this end, we conduct a series of long-term radiation hydrodynamic simulations following star cluster formation, varying the metallicity from Z/Z⊙ = 10−4 to 1. We particularly consider the effects of protostellar radiative feedback, which modify the exact shape of the IMF and determine the star formation efficiency (SFE), i.e. the ratio between the mass in stars and ...
Tópico(s): Stellar, planetary, and galactic studies
2024 - Oxford University Press | Monthly Notices of the Royal Astronomical Society
Ryutaro Tanaka, Yongchuan Lin, Akira Hosokawa, Takashi UEDA, Keiji Yamada,
It is widely known that the electromotive force generated at the interface between the cutting tool and work material, during a metal cutting process, influences the cutting mechanism. Previously published papers describe the influence of the passage of electric current through the contact zone between cutting tool and work material, on tool life in cutting several work materials. However, few papers deal with the influence of this electric current on the behavior of a deposited layer called "belag", ...
Tópico(s): Advanced machining processes and optimization
2009 - Japan Society Mechanical Engineers | Journal of Advanced Mechanical Design Systems and Manufacturing