Shigeo Tanimoto, Takayoshi Kamano,
The reduction of 2-[(2-nitrophenyl)azo]phenols 1 with thiourea S,S-dioxide and sodium hydroxide in a mixture of isopropyl alcohol and water at reflux provide, 2-(2H-benzotriazol-2-yl)phenols 3 in excellent yields.
Tópico(s): Synthesis and Characterization of Heterocyclic Compounds
1986 - Thieme Medical Publishers (Germany) | Synthesis
Yasuo Imai, Ting‐Chao Chou, Kensei Tobinai, Ryuji Tanosaki, Y Morishima, Michinori Ogura, Chihiro Shimazaki, Masafumi Taniwaki, A Hiraoka, Mitsune Tanimoto, Takayoshi Koike, Katsuhisa Kogawa, Hisamaru Hirai, Takashi Yoshida, Kazuo Tamura, Kenji Kishi, T Hotta,
Tópico(s): CAR-T cell therapy research
2005 - Springer Nature | Bone Marrow Transplantation
Shumpei Yamamoto, Hideaki Kinugasa, Kenta Hamada, Masahiro Tomiya, Takayoshi Tanimoto, Akimitsu Ohto, Akira Toda, Daisuke Takei, Minoru Matsubara, Seiyu Suzuki, Kosuke Inoue, Takehiro Tanaka, Sakiko Hiraoka, Hiroyuki Okada, Yoshiro Kawahara,
Although endoscopic resection with careful surveillance instead of total proctocolectomy become to be permitted for visible low-grade dysplasia, it is unclear how accurately endoscopists can differentiate these lesions, as classifying neoplasias occurring in inflammatory bowel disease (IBDN) is exceedingly challenging due to background chronic inflammation. We evaluated a pilot model of an artificial intelligence (AI) system for classifying IBDN and compared it with the endoscopist's ability.This ...
Tópico(s): Inflammatory Bowel Disease
2022 - Wiley | Journal of Gastroenterology and Hepatology
Kenta Hamada, Yoshiro Kawahara, Takayoshi Tanimoto, Akimitsu Ohto, Akira Toda, Toshiaki Aida, Yasushi Yamasaki, Tatsuhiro Gotoda, Taiji Ogawa, Makoto Abe, Shotaro Okanoue, Kensuke Takei, Satoru Kikuchi, Shinji Kuroda, Toshiyoshi Fujiwara, Hiroyuki Okada,
Recently, artificial intelligence (AI) has been used in endoscopic examination and is expected to help in endoscopic diagnosis. We evaluated the feasibility of AI using convolutional neural network (CNN) systems for evaluating the depth of invasion of early gastric cancer (EGC), based on endoscopic images.This study used a deep CNN model, ResNet152. From patients who underwent treatment for EGC at our hospital between January 2012 and December 2016, we selected 100 consecutive patients with mucosal ( ...
Tópico(s): Colorectal Cancer Screening and Detection
2021 - Wiley | Journal of Gastroenterology and Hepatology
Ikuo Nagata, Kazuo Shiraki, K Tanimoto, Yuichiro Harada, Yuji Tanaka, Takayoshi Okada,
Prospective studies of an infant of a mother infected with hepatitis C virus indicated that an HCV infection developed in the infant in early life. Perinatal transmission appeared to be the most likely explanation.
Tópico(s): Liver Disease Diagnosis and Treatment
1992 - Elsevier BV | The Journal of Pediatrics
Takayoshi Suganami, Kanami Tanimoto-Koyama, Junko Nishida, Michiko Itoh, Xunmei Yuan, Shinji Mizuarai, Hidehito Kotani, Shoji Yamaoka, Kensuke Miyake, Seiichiro Aoe, Yasutomi Kamei, Yoshihiro Ogawa,
Previous studies demonstrated that obese adipose tissue is characterized by increased infiltration of macrophages, suggesting that they might represent an important source of inflammation. Using an in vitro coculture system composed of 3T3-L1 adipocytes and RAW264 macrophages, we previously demonstrated that saturated fatty acids (FAs) and tumor necrosis factor (TNF)-alpha derived from adipocytes and macrophages, respectively, play a major role in the coculture-induced inflammatory changes.Coculture ...
Tópico(s): Adipose Tissue and Metabolism
2006 - Lippincott Williams & Wilkins | Arteriosclerosis Thrombosis and Vascular Biology
Hideaki Takagi, T. Nakano, Takayoshi Aoki, Morimasa Tanimoto,
Milk is used and processed under various environmental temperature, and its physicochemical properties are also strongly affected by temperature. Therefore, it is important to reveal the structure of milk at variable temperatures. In this study, the temperature dependence of the inner structure of bovine casein micelles in the temperature range of 10-40 °C was investigated by in-situ small-angle X-ray scattering (SAXS) method. The micelle size calculated from the SAXS profiles using a micelle model ...
Tópico(s): Polysaccharides Composition and Applications
2022 - Elsevier BV | Food Chemistry
Hideaki Takagi, T. Nakano, Takayoshi Aoki, Morimasa Tanimoto,
Changes in milk pH significantly influence the behavior and physical properties of casein micelles; however, the effects of these changes on casein micelle structures are still unclear. The aim of this study was to elucidate the effect of changes in pH range from 5.9 to 7.1 on the structure of casein micelles in milk using small-angle X-ray scattering (SAXS) and ultra small-angle X-ray scattering (USAXS). The casein micelles formed one-dimensional aggregates. The micelle radius decreased with decreasing ...
Tópico(s): Iron Metabolism and Disorders
2024 - Elsevier BV | Food Chemistry
Akihiro Nishiyama, Tadaaki Yamada, Kenji Kita, Rong Wang, Sachiko Arai, Koji Fukuda, Azusa Tanimoto, Shinji Takeuchi, Shoichiro Tange, Atsushi Tajima, Noritaka Furuya, Takayoshi Kinoshita, Seiji Yano,
Purpose: Rearrangement of the neurotrophic tropomyosin receptor kinase 1 (NTRK1) gene, which encodes tyrosine receptor kinase A (TRK-A), occurs in various cancers, including colon cancer. Although entrectinib is effective in the treatment of central nervous system (CNS) metastases that express NTRK1 fusion proteins, acquired resistance inevitably results in recurrence. The CNS is a sanctuary for targeted drugs; however, the mechanism by which CNS metastases become entrectinib-resistant remains elusive ...
Tópico(s): Cancer therapeutics and mechanisms
2018 - American Association for Cancer Research | Clinical Cancer Research
Ryosuke Sato, Kazuyuki Matsumoto, Hideaki Kinugasa, Masahiro Tomiya, Takayoshi Tanimoto, Akimitsu Ohto, Kei Harada, Nao Hattori, Taisuke Obata, Akihiro Matsumi, Kazuya Miyamoto, Kosaku Morimoto, Hiroyuki Terasawa, Yuki Fujii, Daisuke Uchida, Koichiro Tsutsumi, Shigeru Horiguchi, Hironari Kato, Yoshiro Kawahara, Motoyuki Otsuka,
Accurately diagnosing biliary strictures is crucial for surgical decisions, and although peroral cholangioscopy (POCS) aids in visual diagnosis, diagnosing malignancies or determining lesion margins via this route remains challenging. Indigo carmine is commonly used to evaluate lesions during GI endoscopy. We aimed to establish the utility of virtual indigo carmine chromoendoscopy (VICI) converted from POCS images using artificial intelligence.
Tópico(s): Pancreatic and Hepatic Oncology Research
2024 - Elsevier BV | Gastrointestinal Endoscopy
Yuki Fujii, Daisuke Uchida, Ryosuke Sato, Taisuke Obata, Matsumi Akihiro, Kazuya Miyamoto, Kosaku Morimoto, Hiroyuki Terasawa, Tatsuhiro Yamazaki, Kazuyuki Matsumoto, Shigeru Horiguchi, Koichiro Tsutsumi, Hironari Kato, Hirofumi Inoue, Ten Cho, Takayoshi Tanimoto, Akimitsu Ohto, Yoshiro Kawahara, Motoyuki Otsuka,
Rapid on-site cytopathology evaluation (ROSE) has been considered an effective method to increase the diagnostic ability of endoscopic ultrasound-guided fine needle aspiration (EUS-FNA); however, ROSE is unavailable in most institutes worldwide due to the shortage of cytopathologists. To overcome this situation, we created an artificial intelligence (AI)-based system (the ROSE-AI system), which was trained with the augmented data to evaluate the slide images acquired by EUS-FNA. This study aimed to ...
Tópico(s): Pancreatic and Hepatic Oncology Research
2024 - Nature Portfolio | Scientific Reports
Michiko Itoh, Takayoshi Suganami, Noriko Satoh, Kanami Tanimoto-Koyama, Xunmei Yuan, Miyako Tanaka, Hiroyuki Kawano, Takashi Yano, Seiichiro Aoe, Motohiro Takeya, Akira Shimatsu, Hideshi Kuzuya, Yasutomi Kamei, Yoshihiro Ogawa,
Objectives— Fish oil rich in n-3 polyunsaturated fatty acids (PUFAs) or n-3 PUFAs have been shown to reduce the incidence of coronary heart disease. Here we investigated the effect of highly purified eicosapentaenoic acid (EPA) on production of adiponectin, the only established antiatherogenic and antiinflammatory adipocytokine, in rodent models of obesity and human obese subjects. Methods and Results— We demonstrated that EPA increases adiponectin secretion in genetically obese ob/ob mice and high- ...
Tópico(s): Regulation of Appetite and Obesity
2007 - Lippincott Williams & Wilkins | Arteriosclerosis Thrombosis and Vascular Biology
Hideaki Takagi, T. Nakano, Takayoshi Aoki, Morimasa Tanimoto,
Bovine milk is the complex colloidal system containing nano to micrometer scale components. Earlier, our research group reported the structural changes in bovine casein micelles in the temperature range of 10-40 °C by in situ small-angle X-ray scattering (SAXS) [H. Takagi, T. Nakano, T. Aoki and M. Tanimoto, Food Chem., 2022, 393, 133389]. In this study, we extend our previous research by investigating the temperature-associated structural alterations in casein micelles over a wide spatial scale using ...
Tópico(s): Animal Diversity and Health Studies
2023 - Royal Society of Chemistry | Soft Matter
Takayoshi Hashimura, Tetsuya Tanimoto, Tomohiro Morita, Masahiro Kami,
Introduction: Japan is considered to have an overabundance of dentists; however, there are scarce data on regional inequalities in the ratio of dentists to patients. We examined these inequalities in Japan’s Greater Tokyo Area – otherwise known as the Kanto region, and the world’s most populous metropolitan area – by subdividing it into small- and medium-sized medical care zones. Methods: We calculated the number of dentists per 100,000 population using the 2012 Survey of Physicians, Dentists, and Pharmacists ...
Tópico(s): Dental Health and Care Utilization
2018 - Elsevier BV | International Dental Journal
Kazuo Shiraki, K Tanimoto, Kazuhito Yamada, Takayoshi Okada,
Abstract One hundred infants born to hepatitis‐Be antigen (HBeAg)‐negative carrier mothers were followed with or without the administration of hepatitis‐B vaccine (HB vaccine) and/or hepatitis‐B hyperimmune globulin (HBIG). Among the infants without treatment, 7.6% of the infants born to the antibody‐to HBeAg (anti‐HBe)‐positive carrier mothers and 14% of those born to the carrier mothers without HBeAg and anti‐HBe developed HBs‐antigenemia, whereas none of the infants treated became positive for HBsAg. ...
Tópico(s): Hepatitis C virus research
1986 - Wiley | Pediatrics International
Shinsuke Miyazaki, Atsushi Kobori, Hikari Jo, Takehiko Keida, Kazuyasu Yoshitani, Moe Mukai, Yuichiro Sagawa, Tetsuya Asakawa, Eiji Sato, Kazuya Yamao, Tomoki Horie, Mamoru Manita, Hidehira Fukaya, Hidemori Hayashi, Kojiro Tanimoto, Tadateru Iwayama, Suguru Chiba, Akinori Sato, Yukio Sekiguchi, Kenta Sugiura, Shinsuke Iwai, Yuhei Isonaga, Naoyuki Miwa, Nobutaka Kato, Osamu Inaba, Takayoshi Hirota, Yasutoshi Nagata, Yuichi Ono, Hitoshi Hachiya, Yasuteru Yamauchi, Masahiko Goya, Junichi Nitta, Hiroshi Tada, Tetsuo Sasano,
... Horie, Mamoru Manita, Hidehira Fukaya, Hidemori Hayashi, Kojiro Tanimoto, Tadateru Iwayama, Suguru Chiba, Akinori Sato, Yukio Sekiguchi, Kenta Sugiura, Shinsuke Iwai, Yuhei Isonaga, Naoyuki Miwa, Nobutaka Kato, Osamu Inaba, Takayoshi Hirota, Yasutoshi Nagata, Yuichi Ono, Hitoshi Hachiya, Yasuteru ...
Tópico(s): Cardiac electrophysiology and arrhythmias
2023 - Lippincott Williams & Wilkins | Circulation Arrhythmia and Electrophysiology
Shin‐ichiro Noro, Yu Song, Yutaro Tanimoto, Yuh Hijikata, Kazuya Kubo, Takayoshi Nakamura,
Methods relying on the use of solid solutions can be used to produce solid materials having finely controlled physical properties. In the current investigation, we utilized this protocol to prepare solid solutions derived from two different Werner complexes in order to assess the effects of component ratios on acetone vapor adsorption properties. For this purpose, microcrystalline solid solutions with the basic elemental composition α-[Cu(PF6)2(py)4]x[Cu(CF3SO3)2(py)4]1-x (x = 0.75 and 0.5) (α-PAC-2- ...
Tópico(s): Radioactive element chemistry and processing
2020 - Royal Society of Chemistry | Dalton Transactions
Yuichiro Harada, K Tanimoto, Takayoshi Okada, Kazuo Shiraki,
HBe抗体陽性HBVキャリア妊婦から出生し,慢性肝障害をきたした姉弟例を経験した.姉は生後2カ月からB型肝炎ウイルスによると考えられる重症肝炎を発症したが,HBs抗体出現後も中等度の肝機能障害が1年間持続した.分娩時に母親からB型肝炎ウイルスと非A非B型肝炎ウイルスの重複垂直感染を受けた可能性が示唆された.弟はB型肝炎の垂直感染防止のため生直後にHBIGを投与されたが,生後2カ月から11カ月間,肝機能障害が持続した.生後8カ月からHBs抗体の上昇およびHBc抗体の再上昇がみられた.非A非B型肝炎ウイルスがB型肝炎の潜伏期を延長した可能性も考えられた.
Tópico(s): Liver Disease Diagnosis and Treatment
1989 - The Japan Society of Hepatology | Kanzo
Shigeo Tanimoto, Takayoshi Kamano,
Abstract The benzotriazoles (III) are obtained from the 2‐nitrophenylazophenols (I) by reduction with thiourea S,S‐dioxide (II) in the presence of sodium hydroxide.
Tópico(s): Synthesis and Characterization of Heterocyclic Compounds
1986 - Wiley | Chemischer Informationsdienst
Kazuo Shiraki, K Tanimoto, Kazuhito Yamada, Takayoshi Okada,
Abstract In order to prevent the hepatitis B virus carrier state, 190 infants born to hepatitis‐Be antigen positive hepatitis‐B surface antigen carrier mothers were treated with hepatitis‐B hyperimmune globulin(HBIG) and hepatitis‐B vaccine after birth; however, 8 infants(4.2%) ultimately became carriers. There were three different causes for the failure, namely 1) prenatal infection, 2) insufficiency of HBIG to neutralize the virus transmitted, and 3) poor responsiveness of the infant to the vaccine. ...
Tópico(s): Vaccine Coverage and Hesitancy
1986 - Wiley | Pediatrics International
Motohiro Hirao, Atsushi Hosui, Akihiro Mimura, K Ohnishi, Takashi Tanimoto, Toru Okahara, Yuka Sueyoshi, Takayoshi Goto, Takuya Yamada, Naoki Hiramatsu,
For the early diagnosis of malignant biliary stricture due to biliary-pancreatic carcinoma, conventional biliary brush cytology with endoscopic retrograde cholangiopancreatography (ERCP; the conventional method) is not sensitive enough.Two hundred nine patients with biliary stricture who were admitted between September 2015 and June 2020 were enrolled in this study. Biliary brush cytology was performed on all patients. Samples were diagnosed independently by an expert pathologist and medical doctor ...
Tópico(s): Pancreatic and Hepatic Oncology Research
2022 - Elsevier BV | Photodiagnosis and Photodynamic Therapy
Souichi Shiratori, Junichi Sugita, Shuichi Ota, Senji Kasahara, Jun Ishikawa, Takayoshi Tachibana, Yoshiki Hayashi, Goichi Yoshimoto, Tetsuya Eto, Hiromi Iwasaki, Mine Harada, Keitaro Matsuo, Takanori Teshima, Masahiro Imamura, Shuichi Taniguchi, Chihiro Shimazaki, Shinji Nakao, Mitsune Tanimoto, Kenji Imajo, Koichi Akashi, Takanori Teshima, Takashi Okamura, Koji Nagafuji, Toshihiro Miyamoto, Yuju Ohno, Takahiro Fukuda, Tetsuya Eto, Morio Matsumoto, Hirokazu Okumura, Tohru Murayama, Kazutaka Sunami, Naoki Kobayashi, Naoyuki Uchida, Yoshinobu Kanda, Hideki Tsujimura, Koji Kato, Yasushi Takamatsu, Junichi Sugita, Michihiro Hidaka, Yuichiro Nawa, Mine Harada,
Tópico(s): Immune Cell Function and Interaction
2020 - Springer Nature | Bone Marrow Transplantation
Shiou Tanimoto, Akihiro Okada, Takayoshi Kobayashi, Eiji Tokunaga,
The Pockels coefficient of interfacial water between bulk water and a Ti electrode was estimated from the electroreflectance spectra (ΔR/R) to be r13≈−150 pm/V as the maximum value of magnitude, which is comparable in magnitude to the largest coefficient for electrode interfacial water, i.e., 200 pm/V for interfacial water on a transparent oxide electrode. This Pockels signal increased by a factor of about ±3 by applying a DC bias voltage of ±1 V. The reflectance (R) of the Ti electrode had a dip structure ...
Tópico(s): Spectroscopy and Quantum Chemical Studies
2023 - Multidisciplinary Digital Publishing Institute | Applied Sciences
Yu Sato, Shuzou Tanimoto, Masaya Shinohara, Takayoshi Kusuhara, Takashi Nishimura, Takayuki Oono, Sachito Fukuda, Shinichi Takamoto, Kazuhiro Hara, Kengo Tanabe,
Tópico(s): Cardiac Structural Anomalies and Repair
2015 - Elsevier BV | Journal of Cardiac Failure
K Tanimoto, Ryu Matsuda, Takayoshi Okada, Kazuo Shiraki,
Tópico(s): Pneumonia and Respiratory Infections
1987 - The Japan Society of Hepatology | Kanzo
Takeshi Akao, Isao Yashiro, Akira Hosoyama, Hiroshi Kitagaki, H. Horikawa, Daisuke Watanabe, Rinji Akada, Yukio Ando, Satoshi Harashima, Takayoshi Inoue, Yoshihiro Inoue, Susumu Kajiwara, Kodai Kitamoto, Noritoshi Kitamoto, Osamu Kobayashi, Satoshi Kuhara, Tatsuo Masubuchi, Hiroshi Mizoguchi, Yoshihiro Nakao, Atumi NAKAZATO, Masahiro Namise, Takahiro Oba, Tomoo Ogata, Akinori Ohta, Miho Sato, Seiji Shibasaki, Yoshifumi Takatsume, S. Tanimoto, Hirohito Tsuboi, Akira Nishimura, Koji Yoda, Toshihisa Ishikawa, K. Iwashita, Nobuyuki Fujita, Hitoshi Shimoi,
The term 'sake yeast' is generally used to indicate the Saccharomyces cerevisiae strains that possess characteristics distinct from others including the laboratory strain S288C and are well suited for sake brewery. Here, we report the draft whole-genome shotgun sequence of a commonly used diploid sake yeast strain, Kyokai no. 7 (K7). The assembled sequence of K7 was nearly identical to that of the S288C, except for several subtelomeric polymorphisms and two large inversions in K7. A survey of heterozygous ...
Tópico(s): Yeasts and Rust Fungi Studies
2011 - University of Oxford | DNA Research
Mitsuru Munemasa, Tadashi Yoshino, Keita Kobayashi, Takayoshi Miyake, Sumie Takase-Sakugawa, Tomohiko Mannami, Katsuji Shinagawa, Mitsune Tanimoto, Tadaatsu Akagi,
Reportedly, thyroid mucosa-associated lymphoid tissue (MALT) lymphoma is closely associated with Hashimoto's thyroiditis. However, it remains unknown which antigen is closely associated with thyroid MALT lymphoma. We examined whether B cell response to thyroglobulin (Tg), which is a common thyroid-specific autoantigen, is related etiologically to the pathogenesis of thyroid MALT lymphoma. Expression of human Tg antigens and Cluster of differentiation (CD) 35 was examined immunohistochemically in 15 ...
Tópico(s): Thyroid Disorders and Treatments
2009 - Okayama University | Acta medica Okayama
Ayaka Ito, Takayoshi Suganami, Yoshihiro Miyamoto, Yasunao Yoshimasa, Motohiro Takeya, Yasutomi Kamei, Yoshihiro Ogawa,
... 2068Crossref PubMed Scopus (807) Google Scholar, 7Suganami T. Tanimoto-Koyama K. Nishida J. Itoh M. Yuan X. ... 2068Crossref PubMed Scopus (807) Google Scholar, 7Suganami T. Tanimoto-Koyama K. Nishida J. Itoh M. Yuan X. ... 2068Crossref PubMed Scopus (807) Google Scholar, 7Suganami T. Tanimoto-Koyama K. Nishida J. Itoh M. Yuan X. ...
Tópico(s): Immune cells in cancer
2007 - Elsevier BV | Journal of Biological Chemistry
Michiko Itoh, Takayoshi Suganami, Nobutaka Nakagawa, Miyako Tanaka, Yukio Yamamoto, Yasutomi Kamei, Shuji Terai, Isao Sakaida, Yoshihiro Ogawa,
... Google Scholar, 23Itoh M. Suganami T. Satoh N. Tanimoto-Koyama K. Yuan X. Tanaka M. Kawano H. ... described previously.23Itoh M. Suganami T. Satoh N. Tanimoto-Koyama K. Yuan X. Tanaka M. Kawano H. ...
Tópico(s): Adipokines, Inflammation, and Metabolic Diseases
2011 - Elsevier BV | American Journal Of Pathology
Takayuki Kondo, Norikazu Hara, Satoshi Koyama, Yuichiro Yada, Kayoko Tsukita, Ayako Nagahashi, Takeshi Ikeuchi, Kenji Ishii, Takashi Asada, Tetsuaki Arai, Ryo Yamada, Michael W. Weiner, Paul Aisen, Ronald C. Petersen, Clifford R. Jack, William J. Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, John C. Morris, Leslie M. Shaw, Jeffrey Kaye, Joseph F. Quinn, Lisa Silbert, Betty Lind, Raina Carter, Sara Dolen, Lon S. Schneider, Sonia Pawluczyk, Mauricio Beccera, Liberty Teodoro, Bryan M. Spann, James B. Brewer, Helen Vanderswag, Adam Fleisher, Judith L. Heidebrink, Joanne Lord, Sara S. Mason, Colleen S. Albers, David S. Knopman, Kris Johnson, Rachelle S. Doody, Javier Villanueva‐Meyer, Munir Chowdhury, Susan Rountree, Mimi Dang, Yaakov Stern, Lawrence S. Honig, Karen L. Bell, Beau M. Ances, John C. Morris, Maria Carroll, Mary L. Creech, Erin Franklin, Mark A. Mintun, Stacy Schneider, Angela Oliver, Daniel Marson, Randall Griffith, David Clark, David Geldmacher, John Brockington, Erik D. Roberson, Marissa Natelson Love, Hillel Grossman, Effie Mitsis, Raj C. Shah, Leyla deToledo‐Morrell, Ranjan Duara, Daniel Varón, Maria T. Greig, Peggy Roberts, Marilyn Albert, Chiadi U. Onyike, Daniel D’Agostino, Stephanie Kielb, James E. Galvin, Brittany Cerbone, Christina A. Michel, Dana M. Pogorelec, Henry Rusinek, Mony J. de Leon, Lidia Glodzik, Susan De Santi, P. Murali Doraiswamy, Jeffrey R. Petrella, Salvador Borges‐Neto, Terence Z. Wong, Edward Coleman, Charles D. Smith, Gregory A. Jicha, Peter Hardy, Partha Sinha, Elizabeth Oates, Gary Conrad, Anton P. Porsteinsson, Bonnie S. Goldstein, Kim Martin, Kelly M. Makino, M. Saleem Ismail, Connie Brand, Ruth A. Mulnard, Gaby Thai, Catherine Mc-Adams-Ortiz, Kyle Womack, Dana Mathews, Mary Quiceno, Allan I. Levey, James J. Lah, Janet S. Cellar, Jeffrey M. Burns, Russell H. Swerdlow, William M. Brooks, Liana G. Apostolova, Kathleen Tingus, Ellen Woo, Daniel Silverman, Po H. Lu, George Bartzokis, Neill R. Graff‐Radford, Francine Parfitt, Tracy Kendall, Heather Johnson, Martin R. Farlow, Ann Marie Hake, Brandy R. Matthews, Jared R. Brosch, Scott Herring, Cynthia Hunt, Christopher H. van Dyck, Richard E. Carson, Martha G. MacAvoy, Pradeep Varma, Howard Chertkow, Howard Bergman, Chris Hosein, Sandra E. Black, Bojana Stefanovic, Curtis Caldwell, Ging‐Yuek Robin Hsiung, Howard Feldman, Benita Mudge, Michele Assaly, Elizabeth Finger, Stephen Pasternack, Irina Rachisky, Dick Trost, Andrew Kertesz, Charles Bernick, Donna Munic, Marek Marsel Mesulam, Kristine Lipowski, Sandra Weıntraub, Borna Bonakdarpour, Diana Kerwin, Chuang‐Kuo Wu, Nancy Johnson, Carl Sadowsky, Teresa Villena, Raymond Scott Turner, Kathleen Johnson, Brigid Reynolds, Reisa A. Sperling, Keith A. Johnson, Gad A. Marshall, Jerome A. Yesavage, Joy L. Taylor, Barton Lane, Allyson Rosen, Jared Tinklenberg, Marwan N. Sabbagh, Christine M. Belden, Sandra A. Jacobson, Sherye A. Sirrel, Neil W. Kowall, Ronald Killiany, Andrew E. Budson, Alexander Norbash, Patricia Lynn Johnson, Thomas O. Obisesan, Saba Wolday, Joanne Allard, Alan J. Lerner, Paula Ogrocki, Curtis Tatsuoka, Parianne Fatica, Evan Fletcher, Pauline Maillard, John Olichney, Charles DeCarli, Owen Carmichael, Smita Kittur, Michael Borrie, T.-Y. Lee, Robert Bartha, Sterling C. Johnson, Sanjay Asthana, Cynthia M. Carlsson, Steven G. Potkin, Adrian Preda, Dana Nguyen, Pierre N. Tariot, Anna Burke, Nadira Trncic, Adam Fleisher, Stephanie Reeder, Vernice Bates, Horacio Capote, Michelle Rainka, Douglas W. Scharre, Maria Kataki, Anahita Adeli, Earl A. Zimmerman, Dzintra Celmins, Alice D. Brown, Godfrey D. Pearlson, Karen Blank, Karen Anderson, Laura A. Flashman, Marc Seltzer, Mary L. Hynes, Robert B. Santulli, Kaycee M. Sink, Leslie Gordineer, Jeff D. Williamson, Pradeep Garg, Franklin Watkins, Brian R. Ott, Henry Querfurth, Geoffrey Tremont, Stephen Salloway, Paul Malloy, Stephen Correia, Howard J. Rosen, Bruce L. Miller, David C. Perry, Jacobo Mintzer, Kenneth Spicer, David Bachman, Nunzio Pomara, Raymundo Hernando, Antero Sarrael, Norman Relkin, Gloria Chaing, Michael Z. Lin, Lisa Ravdin, Amanda Smith, Balebail Ashok Raj, Kristin Fargher, Takeshi Iwatsubo, Takashi Asada, Hiroyuki Arai, Morihiro Sugishita, Hiroshi Matsuda, Kengo Ito, Michio Senda, Kenji Ishii, Ryozo Kuwano, Takeshi Ikeuchi, Noriko Sato, Hajime Sato, Shun Shimohama, Masaki Saitoh, Rika Yamauchi, Takashi Hayashi, Seiju Kobayashi, Norihito Nakano, Junichiro Kanazawa, Takeshi Ando, Chiyoko Takanami, Masato Hareyama, Masamitsu Hatakenaka, Eriko Tsukamoto, Shinji Ochi, Mikio Shoji, Etsuro Matsubara, Takeshi Kawarabayashi, Yasuhito Wakasaya, Takashi Nakata, Naoko Nakahata, Shuichi Ono, Yoshihiro Takai, Satoshi Takahashi, Hisashi Yonezawa, Junko Takahashi, Masako Kudoh, Makoto Sasaki, Yutaka Matsumura, Yohsuke Hirata, Tsuyoshi Metoki, Susumu Hayakawa, Yuichi Sato, Masayuki Takeda, Toshiaki Sasaki, K. Sera,
Genome-wide association studies have demonstrated that polygenic risks shape Alzheimer's disease (AD). To elucidate the polygenic architecture of AD phenotypes at a cellular level, we established induced pluripotent stem cells from 102 patients with AD, differentiated them into cortical neurons and conducted a genome-wide analysis of the neuronal production of amyloid β (Aβ). Using such a cellular dissection of polygenicity (CDiP) approach, we identified 24 significant genome-wide loci associated with ...
Nature Portfolio