Takashi Sato, Takayuki Kondo, Motoharu Seiki, Akira Itô,
... jpSearch for more papers by this authorTAKAYUKI KONDO, TAKAYUKI KONDO Department of Biochemistry, School of Pharmacy, Tokyo University ... jpSearch for more papers by this authorTAKAYUKI KONDO, TAKAYUKI KONDO Department of Biochemistry, School of Pharmacy, Tokyo University ...
Tópico(s): Enzyme Production and Characterization
1999 - Wiley | Annals of the New York Academy of Sciences
Takayuki Kondo, Kiyoshi Hasegawa, Ryutaro Uchida, Masanori Onishi, Akihiro Mizukami, Kenji Omasa,
... TO ISSUEPREVArticleNEXTAbsorption of Formaldehyde by Oleander (Nerium indicum)Takayuki. Kondo, Kiyoshi. Hasegawa, Ryutaro. Uchida, Masanori. Onishi, Akihiro. Mizukami, ...
Tópico(s): Pigment Synthesis and Properties
1995 - American Chemical Society | Environmental Science & Technology
Bernhard Hemmer, Takayuki Kondo, Bruno Gran, Clemencia Pinilla, Irene Cortese, Jeannick Pascal, Abraham Tzou, Henry F. McFarland, Richard A. Houghten, Roland Martinꝉ,
CD4(+) T lymphocytes usually recognize peptides of 12-16 amino acids in the context of HLA class II molecules. We have recently used synthetic peptide combinatorial libraries to dissect in detail antigen recognition by autoreactive CD4(+) T cell clones (TCC). The results of these studies demonstrated that antigen recognition by T cells is highly degenerate and that many cross-reactive ligands can be defined, some of which much more potent than the selecting autoantigen. Based on these observations, ...
Tópico(s): Immunotherapy and Immune Responses
2000 - Oxford University Press | International Immunology
Bibiana Bielekova, Bonnie L. Goodwin, Nancy Richert, Irene Cortese, Takayuki Kondo, Ghazaleh Afshar, Bruno Gran, J.K. Eaton, Jack P. Antel, Joseph A. Frank, Henry F. McFarland, Roland Martinꝉ,
Tópico(s): Herpesvirus Infections and Treatments
2000 - Nature Portfolio | Nature Medicine
Zsolt Illés, Takayuki Kondo, Jia Newcombe, Nobuyuki Oka, Takeshi Tabira, Takashi Yamamura,
Abstract Human Vα24+ NK T cells are a unique subset of lymphocytes expressing the Vα24JαQ invariant TCR chain. Because they can rapidly produce large amounts of regulatory cytokines, a reduction of NK T cells may lead to the development of certain autoimmune diseases. Using a single-strand conformation polymorphism method, we demonstrate that a great reduction of Vα24JαQ NK T cells in the peripheral blood is an immunological hallmark of multiple sclerosis, whereas it is not appreciable in other ...
Tópico(s): Monoclonal and Polyclonal Antibodies Research
2000 - American Association of Immunologists | The Journal of Immunology
Haruhisa Inoue, N. Nagata, H. Kurokawa, Shinya Yamanaka,
... to all of our coworkers and collaborators, to Takayuki Kondo for drawing the figures and for critical discussions, ...
Tópico(s): Pancreatic function and diabetes
2014 - Springer Nature | The EMBO Journal
Takashi Ayaki, Hidefumi Ito, Hiroko Fukushima, Takeshi Inoue, Takayuki Kondo, Akito Ikemoto, Takeshi Asano, Akemi Shodai, Takuji Fujita, Satoshi Fukui, Hiroyuki Morino, Satoshi Nakano, Hirofumi Kusaka, Hirofumi Yamashita, Masafumi Ihara, Riki Matsumoto, Jun Kawamata, Makoto Urushitani, Hideshi Kawakami, Ryōsuke Takahashi,
Mutations in the valosin-containing protein (VCP) gene were first found to cause inclusion- body myopathy with early-onset Paget disease and frontotemporal dementia (IBMPFD). Mutations in the VCP gene were later reported to occur in familial amyotrophic lateral sclerosis (ALS). But the role of VCP in the neurodegenerative processes that occur in ALS remains unknown. The purpose of the present study was to elucidate the role of VCP in the neurodegeneration seen in sporadic and VCP mutant ALS. Immunohistochemistry ...
Tópico(s): Neurological diseases and metabolism
2014 - Springer Science+Business Media | Acta Neuropathologica Communications
Taro Shimada, Hitoshi Maruyama, Takayuki Kondo, Tadashi Sekimoto, Masanori Takahashi, Osamu Yokosuka,
Tópico(s): Hepatocellular Carcinoma Treatment and Prognosis
2014 - Springer Science+Business Media | European Radiology
Nao Hirata, Masato Nakagawa, Yuto Fujibayashi, Kaori Yamauchi, Asako Murata, Itsunari Minami, Maiko Tomioka, Takayuki Kondo, Ting‐Fang Kuo, Hiroshi Endô, Haruhisa Inoue, Shin‐ichi Sato, Shin Ando, Yoshinori Kawazoe, Kazuhiro Aiba, Koh Nagata, Eihachiro Kawase, Young‐Tae Chang, Hirofumi Suemori, Koji Eto, Hiromitsu Nakauchi, Shinya Yamanaka, Norio Nakatsuji, Kazumitsu Ueda, Motonari Uesugi,
A small-molecule fluorescent probe specific for human pluripotent stem cells would serve as a useful tool for basic cell biology research and stem cell therapy. Screening of fluorescent chemical libraries with human induced pluripotent stem cells (iPSCs) and subsequent evaluation of hit molecules identified a fluorescent compound (Kyoto probe 1 [KP-1]) that selectively labels human pluripotent stem cells. Our analyses indicated that the selectivity results primarily from a distinct expression pattern ...
Tópico(s): DNA and Nucleic Acid Chemistry
2014 - Cell Press | Cell Reports
Takayuki Kondo, Misato Funayama, Kayoko Tsukita, Akitsu Hotta, Akimasa Yasuda, Satoshi Nori, Shinjiro Kaneko, Masaya Nakamura, Ryōsuke Takahashi, Hideyuki Okano, Shinya Yamanaka, Haruhisa Inoue,
Transplantation of glial-rich neural progenitors has been demonstrated to attenuate motor neuron degeneration and disease progression in rodent models of mutant superoxide dismutase 1 (SOD1)-mediated amyotrophic lateral sclerosis (ALS). However, translation of these results into a clinical setting requires a renewable human cell source. Here, we derived glial-rich neural progenitors from human iPSCs and transplanted them into the lumbar spinal cord of ALS mouse models. The transplanted cells differentiated ...
Tópico(s): Pluripotent Stem Cells Research
2014 - Elsevier BV | Stem Cell Reports
Akinori Uruha, Yukiko Hayashi, Yasushi Oya, Madoka Mori‐Yoshimura, Masahiro Kanai, Miho Murata, Mayumi Kawamura, Katsuhisa Ogata, Tsuyoshi Matsumura, Shigeaki Suzuki, Y. Takahashi, Takayuki Kondo, Takeshi Kawarabayashi, Yuko Ishii, Norito Kokubun, Satoshi Yokoi, Rei Yasuda, Jun‐ichi Kira, Satomi Mitsuhashi, S. Noguchi, Ikuya Nonaka, Ichizo Nishino,
Background In hereditary myopathy with early respiratory failure (HMERF), cytoplasmic bodies (CBs) are often localised in subsarcolemmal regions, with necklace-like alignment (necklace CBs), in muscle fibres although their sensitivity and specificity are unknown. Objective To elucidate the diagnostic value of the necklace CBs in the pathological diagnosis of HMERF among myofibrillar myopathies (MFMs). Methods We sequenced the exon 343 of TTN gene (based on ENST00000589042), which encodes the fibronectin-3 (FN3) ...
Tópico(s): Neurogenetic and Muscular Disorders Research
2014 - BMJ | Journal of Neurology Neurosurgery & Psychiatry
Hitoshi Maruyama, Hidehiro Kamezaki, Takayuki Kondo, Tadashi Sekimoto, Masanori Takahashi, Osamu Yokosuka,
To examine the sonographic features of shunt vessels derived from the splenic vein at splenic hilum (SS), and explore the relationship between the SS pattern and clinical presentations.This prospective study in cirrhotic patients consisted of study I (n = 15), which compared the anatomical features of SS at ultrasonography versus angiography, and study II (n = 233), which examined the incidence/haemodynamics of SS and SS-related presentations.Study I showed that SS1 (running toward the upper pole of the ...
Tópico(s): Organ Transplantation Techniques and Outcomes
2013 - Elsevier BV | Clinical Radiology
Yuki Iijima, Takayuki Kondo, Yu Takahashi, Yohe Bando, Naoto Todoroki, Toshimasa Wadayama,
We investigated electrochemical properties for the Pt–Au bimetallic surfaces prepared by 0.3-nm-thick Pt depositions on Au(111), (110), and (100) substrates (Pt0.3nm/Au(hkl)) by molecular beam epitaxy. The Pt0.3nm/Au(111) surface prepared at the substrate temperature of 300 K (300K–Pt0.3nm/Au(111)) showed a corrugated Pt(111) epitaxial surface on which 3–5 nm size monoatomic height Pt islands are located. Oxygen reduction reaction (ORR) activity of the surface was enhanced by a factor of ca. 2 relative ...
Tópico(s): Semiconductor materials and devices
2013 - Institute of Physics | Journal of The Electrochemical Society
Takayuki Kondo, Hitoshi Maruyama, Tadashi Sekimoto, Taro Shimada, Masanori Takahashi, Hidehiro Okugawa, Osamu Yokosuka, Tadashi Yamaguchi,
The aim was to determine the influence of the paraumbilical vein (PUV) patency and its effect on the portal hemodynamics and clinical presentations in cirrhotic patients.In this prospective study of 181 cirrhotic patients (101 males, 80 females; aged 62.6±11.8 y), the portal hemodynamics were assessed using Doppler ultrasonography.The incidence of patent PUV was 26.0% (47/181). The mean flow volume in the portal trunk, the incidence of a left gastric vein with hepatofugal flow, and the grade of the ...
Tópico(s): Organ Transplantation Techniques and Outcomes
2013 - Lippincott Williams & Wilkins | Journal of Clinical Gastroenterology
Takefumi Hitomi, Katsuya Kobayashi, Naoto Jingami, Tomokazu Nakagawa, Hisaji Imamura, Riki Matsumoto, Takayuki Kondo, Kazuo Chin, Ryōsuke Takahashi, Akio Ikeda,
ABSTRACT We recently reported clinical anticipation in Japanese families with benign adult familial myoclonus epilepsy (BAFME). However, it remains unknown whether clinical anticipation is predominantly associated with paternal or maternal transmission. We investigated the relationship between gender of the transmitting parent and clinical anticipation in nine BAFME families. Clinical anticipation regarding either cortical tremor or generalised seizures was observed in all 12 parent/child pairs (8 ...
Tópico(s): Genetics and Neurodevelopmental Disorders
2013 - Wiley | Epileptic Disorders
Takayuki Kondo, Masashi Asai, Kayoko Tsukita, Yumiko Kutoku, Yutaka Ohsawa, Yoshihide Sunada, Keiko Imamura, Naohiro Egawa, Naoki Yahata, Keisuke Okita, Kazutoshi Takahashi, Isao Asaka, Takashi Aoi, Akira Watanabe, Kaori Watanabe, Chie Kadoya, Rie Nakano, Dai Watanabe, Kei Maruyama, Osamu Hori, Satoshi Hibino, Tominari Choshi, Tatsutoshi Nakahata, Hiroyuki Hioki, Takeshi Kaneko, Motoko Naitoh, Katsuhiro Yoshikawa, Satoko Yamawaki, Shigehiko Suzuki, Ryuji Hata, Shu-ichi Ueno, Tsuneyoshi Seki, Kazuhiro Kobayashi, Tatsushi Toda, Kazuma Murakami, Kazuhiro Irie, William L. Klein, Hiroshi Mori, Takashi Asada, Ryōsuke Takahashi, Nobuhisa Iwata, Shinya Yamanaka, Haruhisa Inoue,
Summary Oligomeric forms of amyloid-β peptide (Aβ) are thought to play a pivotal role in the pathogenesis of Alzheimer's disease (AD), but the mechanism involved is still unclear. Here, we generated induced pluripotent stem cells (iPSCs) from familial and sporadic AD patients and differentiated them into neural cells. Aβ oligomers accumulated in iPSC-derived neurons and astrocytes in cells from patients with a familial amyloid precursor protein (APP)-E693Δ mutation and sporadic AD, leading to endoplasmic reticulum ( ...
Tópico(s): Cholinesterase and Neurodegenerative Diseases
2013 - Elsevier BV | Cell stem cell
Yushi Imai, Tetsuhiro Chiba, Takayuki Kondo, Hiroaki Kanzaki, Kengo Kanayama, Junjie Ao, Ryuta Kojima, Yuko Kusakabe, Masato Nakamura, Tomoko Saito, Ryo Nakagawa, Eiichiro Suzuki, Shingo Nakamoto, Ryosuke Muroyama, Akinobu Tawada, Tomoaki Matsumura, Tomoo Nakagawa, Jun Kato, Ai Kotani, Hisahiro Matsubara, Naoya Kato,
Programmed death-ligand 1 (PD-L1) plays an essential role in tumor cell escape from anti-tumor immunity in various types of cancer, including gastric cancer (GC). The present study investigated the intracellular and membrane-bound expression of PD-L1 in the GC cell lines MKN1, MKN74, KATO III and OCUM-1. Furthermore, soluble PD-L1 (sPD-L1) level in the supernatant of GC cells and the serum of patients with GC and healthy controls was determined by ELISA. Interferon (IFN)-γ treatment of cells resulted ...
Tópico(s): Immune cells in cancer
2020 - Spandidos Publishing | Oncology Letters
Susumu Maruta, Sadahisa Ogasawara, Yoshihiko Ooka, Masamichi Obu, Masanori Inoue, Norio Itokawa, Yuki Haga, Atsuyoshi Seki, Shinichiro Okabe, Ryosaku Azemoto, Ei Itobayashi, Masanori Atsukawa, Nobuyuki Sugiura, Hideaki Mizumoto, Keisuke Koroki, Kengo Kanayama, Hiroaki Kanzaki, Kazufumi Kobayashi, Soichiro Kiyono, Masato Nakamura, Naoya Kanogawa, Tomoko Saito, Takayuki Kondo, Eiichiro Suzuki, Shingo Nakamoto, Akinobu Tawada, Tetsuhiro Chiba, Makoto Arai, Tatsuo Kanda, Hitoshi Maruyama, Naoya Kato,
The present study aimed to assess the efficacy and safety of lenvatinib and verify the possibility of lenvatinib for the expanded indication from the REFLECT trial in patients with advanced hepatocellular carcinoma (HCC) in real-world practice, primarily focusing on the population that was excluded in the REFLECT trial.We retrospectively collected data on patients with advanced HCC who were administered lenvatinib in 7 institutions in Japan.Of 152 advanced HCC patients, 95 and 57 patients received ...
Tópico(s): Colorectal Cancer Treatments and Studies
2020 - Karger Publishers | Liver Cancer
Cornelius Engelmann, Mohammed Sheikh, Shreya Sharma, Takayuki Kondo, Henry Loeffler‐Wirth, Yu Bao Zheng, Simone Novelli, Andrew Hall, Annarein Kerbert, Jane Macnaughtan, Rajeshwar P. Mookerjee, Abeba Habtesion, Nathan Davies, Tauhid Ali, Saurabh Gupta, Fausto Andreola, Rajiv Jalan,
Toll-like receptor 4 (TLR4) plays an essential role in mediating organ injury in acute liver failure (ALF) and acute-on-chronic liver failure (ACLF). Herein, we assess whether inhibiting TLR4 signaling can ameliorate liver failure and serve as a potential treatment.Circulating TLR4 ligands and hepatic TLR4 expression were measured in plasma samples and liver biopsies from patients with cirrhosis. TAK-242 (TLR4 inhibitor) was tested in vivo (10 mg/kg intraperitoneally) in rodent models of ACLF (bile duct ...
Tópico(s): Drug-Induced Hepatotoxicity and Protection
2020 - Elsevier BV | Journal of Hepatology
Sadahisa Ogasawara, Yoshihiko Ooka, Keisuke Koroki, Susumu Maruta, Hiroaki Kanzaki, Kengo Kanayama, Kazufumi Kobayashi, Soichiro Kiyono, Masato Nakamura, Naoya Kanogawa, Tomoko Saito, Takayuki Kondo, Eiichiro Suzuki, Shingo Nakamoto, Akinobu Tawada, Tetsuhiro Chiba, Makoto Arai, Jun Kato, Naoya Kato,
In patients with unresectable hepatocellular carcinoma (HCC) without both macrovascular invasion and extrahepatic metastasis, the initial treatment choice recommended is transarterial chemoembolization (TACE). Before sorafenib came into wide use, TACE had been pointlessly carried out repeatedly. It was in the early 2010s that the concept of TACE refractory was advocated. Two retrospective studies from Japan indicated that conversion from TACE to sorafenib the day after patients were deemed as TACE ...
Tópico(s): Liver physiology and pathology
2020 - Korean Association for the Study of the Liver | Clinical and Molecular Hepatology
K. Ishida, Takayuki Kondo, Yoshio Kitaoka, Kei Asayama,
Nuclear quadrupole resonance (NQR) of Cu in (La 1- x Sr x ) 2 CuO 4 system (0.075≦ x ≦0.15) has been performed where the system is transformed from the high- T c superconducting to the normal metallic state. The NQR frequency increases and the spectrum is broadened with increasing x . The nuclear spin-lattice relaxation rate 1/ T 1 shows a remarkable distribution for more than x =0.125. For the nonsuperconducting compound of x =0.15, each component of 1/ T 1 is suppressed as compared to that in the superconducting ...
Tópico(s): Magnetic and transport properties of perovskites and related materials
1989 - Physical Society of Japan | Journal of the Physical Society of Japan
Yoshio Kitaoka, Shigeru Hiramatsu, Takayuki Kondo, Kei Asayama,
The nuclear relaxation rate 1/ T 1 and the Knight shift have been studied for boththe Cu–O plane and chain sites by Cu nuclear quadrupole (NQR) and magnetic resonance (NMR) techniques. Below T c =92 K, 1/ T 1 for the plane site decreases markedly without the enhancement just below T c characteristic for the BCS superconductor, and the Knight shift also shows a more rapid reduction than the BCS prediction, giving evidence of a dominant singlet pairing. In contrast, 1/ T 1 for the chain site shows a ...
Tópico(s): Magnetic properties of thin films
1988 - Physical Society of Japan | Journal of the Physical Society of Japan
Takayuki Kondo, Noriyuki Wakabayashi,
To test the hypothesis that loss of molar support causes increased stress and strain in the periodontal structures surrounding the premolars, and to assess the influence of denture use on stress distribution. Subjects included female patients with unilateral and bilateral loss of mandibular molar teeth and controls with complete dentition (n = 7 in each group). The subjects included had normal dentition mesial to the edentulous region and use of a lower free-end saddle removable partial denture. Occlusal ...
Tópico(s): Orthodontics and Dentofacial Orthopedics
2009 - Elsevier BV | Journal of Dentistry
Takamitsu Mizota, Chiaki Fujita‐Kambara, Nemu Matsuya, Shinji Hamasaki, Takayasu Fukudome, Hirofumi Goto, Shunya Nakane, Takayuki Kondo, Hidenori Matsuo,
Background : It has become increasingly clear that polyunsaturated fatty acids (PUFAs) have immunomodulatory effects. However, the intake of these fatty acids used in animal studies often greatly exceeds dietary human intake. Whether differences in the composition of fatty acids that are consumed in amounts consistent with normal dietary intake can influence immune function remains uncertain. Methods : We manufactured 3 types of liquid diet, related to modified fatty acid composition (ω‐6/ω‐3 = 0.25, 2. ...
Tópico(s): Cholesterol and Lipid Metabolism
2009 - Wiley | Journal of Parenteral and Enteral Nutrition
Sachio Shimizu, Takayuki Kondo, T. Kohashi, M. Tsurata, T. Komuro,
A new auto exposure control system for digital cameras was developed. This system used a new parameter and a new algorithm to detect the extent of backlighting and excessive frontlighting. This algorithm compensates exposure in the case of backlighting or excessive frontlighting, regardless of the position of objects. To achieve this compensation, a new criterion parameter called HIST was introduced in the system. HIST is defined as the ratio between the number of pixels with brightnesses higher ...
Tópico(s): Building Energy and Comfort Optimization
1992 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Consumer Electronics
Takayuki Kondo, Kazuya Takahashi, N. Kohara, Yuji Takahashi, Shigenari Hayashi, Hiroko Takahashi, Hidenori Matsuo, Mineo Yamazaki, K Inoue, Katsuichi Miyamoto, Takashi Yamamura,
Abstract The present short communication paper describes the methodological approach of applying the Health Belief Model to the use COVID-19 immunity certificates in the UK. We designed an online survey including an adaptation of the following Health Belief Model constructs: perceived COVID-19 susceptibility, perceived COVID-19 severity, perceived benefits of using immunity certificates, perceived barriers from using immunity certificates, perceived severity of not using immunity certificates, and perceived ...
Tópico(s): Immune Response and Inflammation
2002 - Lippincott Williams & Wilkins | Neurology
Marina Cella, Cecilia Buonsanti, Carey Strader, Takayuki Kondo, Andrea Salmaggi, Marco Colonna,
TREM-2 is an immunoglobulin-like cell surface receptor associated with DAP12/KARAP that activates monocyte-derived dendritic cells (DCs) in vitro. Recently, it has been shown that genetic defects of human DAP12/KARAP and TREM-2 result in a rare syndrome characterized by bone cysts and presenile dementia called Nasu-Hakola disease. This observation suggests that TREM-2 may function in myeloid cells other than DCs, most probably osteoclasts (OCs) and microglial cells, which are involved in bone modeling ...
Tópico(s): Immune cells in cancer
2003 - Rockefeller University Press | The Journal of Experimental Medicine
Wendy Noble, Vicki Olm, Kazuyuki Takata, Evelyn Casey, O Mary, Jordana L. Meyerson, Kate Gaynor, John J. LaFrancois, Lili Wang, Takayuki Kondo, Peter Davies, Mark P. Burns, Veeranna, Ralph A. Nixon, Dennis W. Dickson, Yasuji Matsuoka, Michael K. Ahlijanian, Lit-Fui Lau, Karen Duff,
Tópico(s): Neuroinflammation and Neurodegeneration Mechanisms
2003 - Cell Press | Neuron
M. Araki, Takayuki Kondo, Jenny E. Gumperz, Michael B. Brenner, Sachiko Miyake, Takashi Yamamura,
Although CD1d‐restricted NKT cells have been implicated as a participant in the regulatory mechanism of autoimmune diseases, it remains unclear how they would regulate human autoimmune diseases such as multiple sclerosis (MS). Furthermore, although the NKT cells comprise CD4+ and CD4– populations, prior studies have often represented them as simply a CD4– population. Given that CD4+ and CD4– NKT cells may represent functionally distinct populations, it appears crucial to examine the individual NKT ...
Tópico(s): IL-33, ST2, and ILC Pathways
2003 - Oxford University Press | International Immunology
Takashi Yamamura, Takayuki Kondo, Susumu Sakanaka, Milena Kozovska, Tongchao Geng, Keikichl Takahashi, Takeshi Tabira,
Experimental autoimmune encephalomyelitis (EAE) is an animal autoimmune disease mediated by CD4+ T cells. Analysis of TCR expression revealed that limited TCR elements (V beta 8.2, V alpha 2 or 4) were utilized by myelin basic protein (MBP) specific T cells in mice with H-2u haplotype and Lewis rats. The usage of a particular beta chain complementarity determining region 3 (CDR3) motif has also been shown. However, it remains unclear to what extent these observations can be extrapolated. Here we studied ...
Tópico(s): Monoclonal and Polyclonal Antibodies Research
1994 - Oxford University Press | International Immunology