Oliver S. Martin, Gerald Holtham, Director, , Ian Flintoff, Bel Mooney, John Fingleton, Ronald Payne, Simon Barnes, Magnus Linklater, Don Quixote, Janet Bush, Economics Correspondent, Harvey Elliott, Richard Thomas, J. Anthony Clare, Ross Tieman, Industrial Correspondent, James Landale, Political Reporter, Philip Howard, Hilary Finch, Andrew Pierce and Marianne Darch, Jeremy Kingston, Rachel Campbell-Johnston, Jeremy Laurance Health Correspondent, Ted Adams, H. Halksworth, Carl Mortished, Simon Wilde, Roger Maynard, Colin Narbrough, World Trade Correspondent, Eve-Ann Prentice, Diplomatic Correspondent, Geoff Brown, Robert Sheehan, Bridge Correspondent, Robert Miller, Giles Coren, Martin Fletcher, Noel Falconer, Stuart Jones, Rupert Cox, M. J. D. Walliker, Richard Bewes, John Hopkins, Golf Correspondent, Andrew Pierce and Philip Bassett, Peter Ball, Alice Thomson Political Reporter, John O'leary, Education Editor, J. Tanner, Peter Jackson, Raymond Keene Chess Correspondent, Richard Evans, Racing Correspondent, Dr Trisha Greenhalgh, Martin Barrow, John T. Smith, Libby Purves, Peter Waymark, Michael Evans, Defence Correspondent, Stuart Jones, Tennis Correspondent, Rodney Milnes, Richard Duce and Jonathan Prynn, Robert Bruce, Michael Clark, Eileen Fursland, Anatole Kaletsky, Cherry Orchard, Simon Boccanegra, Helen Whitten, John O'leary, Peter Barnard, Derwent May, Patricia Tehan, Banking Correspondent, Linda Mitchell, Philip Bassett, John Woodcock, Michael Evans, Defence Correspondent, and Stacy Sullivan, Janet Daley, David Miller, Arthur Leathley, Political Correspondent, Raymond Keene, Jonathan Prynn, Christine Buckley, David Robinson, Peter Davalle, Tim Renton, Alix Ramsay, Paul Wilkinson, P. H. S, Richard Evans, David Ekserdjian, Michael Arditti, Rodney Brooke, Jill Sherman, David Powell, Athletics Correspondent, Nicholas Wood and Michael Binyon, Roger Boyes, Nigel Hawkes, Science Editor, James Woodall, Steve Corbett, Philip Webster, Political Editor, Nicholas Wood, Chief Political Correspondent, Adam Fresco, P. A. Whitaker, Ian Murray, Community Correspondent, William Rees-Mogg, Joanna Pitman, David Churchill, Giles Whittell, Mary Scott-Oldfield, Cecily Lowenthal, Matthew Parris, Michael Hornsby, Peter Riddell, Ben MacIntyre, D. B. Welbourn, Alan Lee Cricket Correspondent, Richard Beeston, Nadine Meisner, David Walker, Bruce Boucher, Philip Pangalos, Kate Bassett, Martin Waller, Christopher Walker Middle East Correspondent, Michael Horsnell, Nigel Hawkes Science Editor, Alan Coren, Alan Togood, Horticultural Correspondent, Nicholas Sercombe, Anthony Davis, Gwen Robinson, Tom Rhodes, A. E. Knight, Dr Thomas Stuttaford, Marianne Curphey, Frances Gibb Legal Correspondent, Jack Bailey, Jane Briggs, Arthur Leathley, Catherine Milton and Jeremy Laurance, Alexandra Frean and Dalya Alberge, Alice Thomson, Political Reporter, W. J. C. Cairns, Jonathan Prynn, Transport Correspondent, and Steve Keenan, Ross Tieman, Matthew Bond, Anthony Howard, Jonathan Mirsky, Christopher Irvine,
... February 11,1919 Forthcoming Marriages and Marriages MacMillan Takeo Fukuda Takeo Fukuda, Prime Minister of Japan. 1976 78, died yesterday ...
1995 - Gale Group | TDA
Ryozo Oishi, Noriko Suenaga, Tadashi Hidaka, Takeo Fukuda,
... by this author on: Oxford Academic Google Scholar Takeo Fukuda Takeo Fukuda Department of Pharmacology, Faculty of Medicine, Kyushu University ...
Tópico(s): Antibiotics Pharmacokinetics and Efficacy
1979 - Oxford University Press | Journal of Pharmacy and Pharmacology
By Melvyn Westlake, From Alan Hamilton, By George Clark Political Correspondent, By Hugh Noyes Parliamentary Correspondent, From Nicholas Ashford, By Kenneth Owen Technology Correspondent, From Aruthur Osman, From Annabel Ferriman, By Our Political Reporter, By Christopher Warman Local Government Correspondent, By Robert Parker, From John Young Planning Reporter, By Philip Howard, By Pat Healey Social Services Correspondent, By Our Political Correspondent, By Peter Hill, By Hugh Clayton Agricultural Correspodent, By Robin Young, By Stewart Tendler, By Martin Huckerby, By Craig Seton, By Peter Hennessy, By Diana Geddes Education Correspondent, By a Staff Reporter, By Geraldine Norman Sale Room Correspondent, From Peter Nichols, From Jose Shercliff, From Our Correspondent, From Our Own Correspondent, By David Spanier Diplomatic Correspondent, From Michael Leapmann, From Mario Modiano, From Patrick Brogan, From Charles Harrison, From Michael Knipe, From David Cross, From Richard Wigg, From Ronald Faux, From Jean Thoraval, From Peter Hazelhurst, From Michael Binyon, By Norman Fox Football Correspondent, From Nicholas Keith, By John Woodcock Cricket Correspondent, By Michael Phillips, By Rex Bellamy Tennis Correspondent, From Mitchell Platts, Irving Wardle, John Percival, William Mann, Paul Griffiths, Michael Church, Ned Chaillet, by Prudence Glynn, Michael Ratcliffe, Kay Dick, Laurence Cotterell, Terence de Vere White, Paul Barker, William Haley, Philippa Toomey, PHS, William Frankel, ROBERT SMITH, , G. H. G. NORMAN, , STAN NEWENS, , MARTIN FLANNERY, , AUDREY WISE, , GEORGE RODGERS, , PETER PORTEOUS, , CHRIS BUSHELL, , IAN ORR-EWING, , MARCIA SANDERS, , R. C. YOUNG, , STEPHEN GREEN, , ALASTAIR DUNCAN, , D. J. FITZPATRICK, , ROWLAND E. HILL, , FLORA JACOBS, , ROSAMUND GARROW, , TOM NORMANTON, , R. WALTER, , PHYLLIS M. HALLIDAY, , DAVID PENFOLD, , NAN EDMUNDS, , GEORGE PRICE, , ANTHONY HODGETTS, , NiCHOLAS HERVEY, , By Our Horticultural Correspondent, By Peter Hill Industrial Correspondent, From Frank Vogl US Economics Correspondent, By Our Financial Staff, By Malcolm Brown, By Richard Allen Insurance Correspondent, By Fred Emery Political Editor, Peter Wainwright, From John Huxley Loch Kishorn, By Edward Townsend, By R. W. Shakespeare, From John Earle, By Derek Harris, By Patricia Tisdall, Patricia Tisdall, By Our Commercial Editor, P. S. LAI, , GRAHAM R. NEWMAN, , MICHAEL ROOS, , G. M. NEILD, , R. SULLIVAN, , BY THE FINANCIAL EDITOR, David Blake, By Tony May, By Peter Wainwright, By Ray Maughan, By Richard Allen, By Michael Prest, John Blunsden,
... pound hit Haden Carrier, President Carter and Mr Takeo Fukuda after their three hour, 'Largest object ever moved' ...
1978 - Gale Group | TDA
Tomoko Miyagawa, Keisuke Nagai, Asami Yamada, Yoshinori Sugihara, Takeo Fukuda, Takashi Fukuda, Ryuji Uchida, Hiroshi Tomoda, Satoshi Ōmura, Tohru Nagamitsu,
... ATomoko Miyagawa, Keisuke Nagai, Asami Yamada, Yoshinori Sugihara, Takeo Fukuda, Takashi Fukuda, Ryuji Uchida, Hiroshi Tomoda, Satoshi O̅mura, ...
Tópico(s): Synthesis and Biological Activity
2011 - American Chemical Society | Organic Letters
Jim Mccabe, Colin Bilkus, Michael Goold, Martin Lee, Stuart Marcy, Nichola Harman, Hoyt Wess, Aidan Foster-Carter, Edward Marks, Christian Langfelder, Douglas Keenan, Richard Morawetz, J.Z. Turner, Jeffrey Deboy, Charles Salvatori,
... Business & Personal Business For Sale Business & Personal Obituary Takeo Fukuda Output, Demand And Jobs Prices And Wages Commodity ...
1995 - Gale Group | The Economist
... the Fukuda Doctrine by then Japanese Prime Minister Takeo Fukuda in 1977. The Fukuda Doctrine, the first doctrine ...
Tópico(s): Japanese History and Culture
2006 - ISEAS–Yusof Ishak Institute | Contemporary Southeast Asia
Takashi Hamada, Motofumi Torikai, Ai Kuwazuru, Motoyuki Tanaka, Naoto Horai, Takeshi Fukuda, Shingo Yamada, Shinichi Nagayama, Kanehisa Hashiguchi, Nobuhiko Sunahara, Koichiro Fukuzaki, Ryoichi Nagata, Setsuro Komiya, Ikuro Maruyama, Takeo Fukuda, Kazuhiro Abeyama,
Abstract Objective Tissue hypoxia is closely associated with arthritis pathogenesis, and extracellular high mobility group box chromosomal protein 1 (HMGB‐1) released from injured cells also has a role in arthritis development. This study was thus undertaken to investigate the hypothesis that extracellular HMGB‐1 may be a coupling factor between hypoxia and inflammation in arthritis. Methods Concentrations of tumor necrosis factor α, interleukin‐6, vascular endothelial growth factor, lactic acid, ...
Tópico(s): Neutrophil, Myeloperoxidase and Oxidative Mechanisms
2008 - Wiley | Arthritis & Rheumatism
Multispan suspension bridges can be exactly and conveniently analyzed by the writer's method, which was derived by means of finite difference calculus with due consideration to the flexure of towers. The method can be applied to bridges with any number of spans, irrespective of whether the cables rest on movable saddles or are anchored at tower tops. Results are shown of analyses made on a 5,000 m five-span bridge with a 1,500 m center span and on a 3,220 m four-span bridge, both tentatively designed ...
Tópico(s): Mechanical stress and fatigue analysis
1967 - American Society of Civil Engineers | Journal of the Structural Division
Takeo Fukuda, Tadatoshi KITAO, HIROTOSHI TANIKAWA, Genji Sakaguchi,
An outbreak of type B botulism occurred in Miyazaki Prefecture in August, 1969. There were 21 cases of which three resulted in death of patients. This was the first outbreak of human botulism of a type other than type E in Japan. Type B toxin was demonstrated in fecal specimens; Clostridium botulinum type B was isolated from a single patient. Bottled caviar imported from West Germany was most strongly suspected of being the vehicle.
Tópico(s): Parkinson's Disease Mechanisms and Treatments
1970 - National Institute of Infectious Diseases | Japanese Journal of Medical Science and Biology
Noriko Suenaga, Katsushi Yamada, Takeo Fukuda,
Tópico(s): Diet and metabolism studies
1977 - Elsevier BV | Brain Research
Masanori Iye, Fumihide Iwamuro, Toshinori Maihara, Satoshi Miyazaki, Sadanori Okamura, Kazuhiro Shimasaku, Chris Simpson, Masayuki Akiyama, Hiroyasu Ando, Tetsuo Aoki, Tsutomu Aoki, Yoshihiro Chikada, Mamoru Doi, Noboru Ebizuka, Takeo Fukuda, Hisanori Furusawa, Miwa Goto, M. Hamabe, Ryuji Hata, Masahiko Hayashi, Saeko S. Hayashi, T. Horaguchi, Shinichi Ichikawa, Takashi Ichikawa, Masatoshi Imanishi, Katsumi Imi, Motoko Inata, S. Isobe, Yoichi Itoh, Junichi Iwai, Norio Kaifu, Yukiko Kamata, Tomio Kanzawa, Hiroshi Karoji, Nobunari Kashikawa, Taichi Kato, Wataru Kawasaki, Masahiko Kimura, Naoto Kobayashi, Yukiyasu Kobayashi, Keiichi Kodaira, Yutaka Komiyama, George Kosugi, Tomio Kurakami, Yoshitaka Mikami, Akihiko Miyashita, Takashi Miyata, Y. Mizumoto, Kentaro Motohara, M. Nakagiri, Koich Nakajima, Kyoko Nakamura, Fumiaki Nakata, Kyoji Nariai, Eiji Nishihara, Jun Nishikawa, Shiro Nishimura, Tetsuo Nishimura, Tetsuo Nishino, Kunio Noguchi, Takeshi Noguchi, Junichi Noumaru, Ryusuke Ogasawara, Norio Okada, Kiichi Okita, Koji Omata, Norio Oshima, Masashi Otsubo, Shin Oya, Goro Sasaki, Toshiyuki Sasaki, Yasuhiro Sawada, K. Sekiguchi, M. Sekiguchi, Ian Shelton, Hiroshi Suto, Katsuyuki Suzuki, Tomoyuki Taguchi, Hideki Takami, Tadafumi Takata, Naruhisa Takato, Yoichi Tamura, Hirohisa Tanabe, Kyoko K. Tanaka, Wataru Tanaka, Hiroshi Terada, Daigo Tomono, Yasuo Torii, Hiroyuki Tsukamoto, Tomonori Usuda, J. Watanabe, Masaru Watanabe, Masafumi Yagi, Takuya Yamashita, Yasumasa Yamashita, Naoki Yasuda, M. Yoshida, Shigeomi Yoshida, Masami Yutani,
We report on the results of optical and near-infrared photometry of the cluster of galaxies A 851 (= CL 0939+4713) carried out as one of the first-light observations of the 8.2 m Subaru telescope on Mauna Kea. Images as sharp as 0″.3 FWHM in K′ and 0″.45 in R were obtained in these observations. The 3σ limiting magnitudes for points sources in 0″.3 seeing with a 0″.6 software aperture were shown to go down to R = 28.1, J = 25.1, and K′; = 24.0, respectively, for about 1 hour integration. Subaru photometry ...
Tópico(s): Galaxies: Formation, Evolution, Phenomena
2000 - Oxford University Press | Publications of the Astronomical Society of Japan
Norio Kaifu, Tomonori Usuda, Saeko S. Hayashi, Yoichi Itoh, Masayuki Akiyama, Takuya Yamashita, Yasushi Nakajima, Yoichi Tamura, Shu‐ichiro Inutsuka, Masahiko Hayashi, Toshinori Maihara, Fumihide Iwamuro, Kentaro Motohara, J. Iwai, Hirohisa Tanabe, Tomoyuki Taguchi, Ryuji Hata, Hiroshi Terada, Miwa Goto, Hiroyasu Ando, Tetsuo Aoki, Yoshihiro Chikada, Mamoru Doi, Noboru Ebizuka, Takeo Fukuda, M. Hamabe, Tetsuo Hasegawa, T. Horaguchi, Shinichi Ichikawa, Takashi Ichikawa, Masatoshi Imanishi, Katsumi Imi, Motoko Inata, S. Isobe, Masanori Iye, Yukiko Kamata, Tomio Kanzawa, Hiroshi Karoji, Nobunari Kashikawa, Hirokazu Kataza, Taichi Kato, Naoto Kobayashi, Yukiyasu Kobayashi, Keiichi Kodaira, George Kosugi, Tomio Kurakami, Yoshitaka Mikami, Shoken M. Miyama, Akihiko Miyashita, Takashi Miyata, Satoshi Miyazaki, Y. Mizumoto, M. Nakagiri, Koich Nakajima, Kyoko Nakamura, Kyoji Nariai, Eiji Nishihara, Jun Nishikawa, Shiro Nishimura, Tetsuo Nishimura, Tetsuo Nishino, Kunio Noguchi, Takeshi Noguchi, Junichi Noumaru, Ryusuke Ogasawara, Norio Okada, Kiichi Okita, Koji Omata, Norio Oshima, Masashi Otsubo, Goro Sasaki, Toshiyuki Sasaki, M. Sekiguchi, K. Sekiguchi, Ian Shelton, Chris Simpson, Hiroshi Suto, Hideki Takami, Tadafumi Takata, Naruhisa Takato, Kyoko K. Tanaka, Wataru Tanaka, Daigo Tomono, Yasuo Torii, Koichi Waseda, J. Watanabe, Masaru Watanabe, Masafumi Yagi, Yasumasa Yamashita, Naoki Yasuda, M. Yoshida, Shigeomi Yoshida, Masami Yutani,
This paper describes the first light and subsequent test observations with the 8.2 m aperture Subaru Telescope constructed at the summit of Mauna Kea. Following the engineering first light, which started 1998 December, the astronomical first light and test observations were carried out in 1999 January with 4 testing instruments under seeing conditions of 0″.2*#x2013;0″.5 for near-infrared and 0″.3–0″.6 for optical wavelengths. The actively supported primary mirror was shown to achieve an overall ...
Tópico(s): Astronomical Observations and Instrumentation
2000 - Oxford University Press | Publications of the Astronomical Society of Japan
Kinji Izumi, H Igisu, Takeo Fukuda,
Nowadays various analgesic medications are used for the management of acute and chronic pain. Among these opioid and non-steroidal anti-inflammatory drugs stand in the first line of therapy, however, prolonged administration of these substance is generally challenged by development of analgesic tolerance in patients. Therefore, it is highly valuable to find new pharmacological strategies for prolonged therapeutic procedures. In this respect, Taurine, a free amino acid, has been shown to induce significant ...
Tópico(s): Neuroscience and Neuropharmacology Research
1975 - Elsevier BV | Brain Research
Takeo Fukuda, Yasunori Araki, Noriko Suenaga,
Effects of intraventricular injection of 6-hydroxydopamine (6-OHDA) on maximal electroshock seizures and decapitation convulsions were investigated in mice. The incidence of the clonic phase of maximal electroshock seizure was suppressed by 6-OHDA. The time course of the suppression was in good agreement with the decreased level of whole brain norepinephrine. The incidence of clonic convulsions following decapitation was also suppressed by 6-OHDA. On the contrary, the tonic phase of maximal electroshock ...
Tópico(s): Botulinum Toxin and Related Neurological Disorders
1975 - Elsevier BV | Neuropharmacology
Kanji Izumi, Hideki Igisu, Takeo Fukuda,
Tópico(s): Prenatal Substance Exposure Effects
1974 - Elsevier BV | Brain Research
On 18 August 1977, the Japanese Prime Minister, Takeo Fukuda, delivered a summarizing speech in Manila at the ...
Tópico(s): Japanese History and Culture
1980 - ISEAS–Yusof Ishak Institute | Contemporary Southeast Asia
Takeo Fukuda, Tohoru SASAHARA, Tadatoshi KITAO,
Hyuganetsu disease was caused by ingestion of raw gray mullet, indicating an endoparasite-born rickettsios is.Attempts were made to isolate causative rickettsia from the parasites of the fish. Metacercaria of Stellantchasmus falcatus, homogenized or untreated, were inoculated into mice via peritoneal or oral routes. The mice were autopsied after 14 days and 30 days, respectively, and thereafter blind passages were done every 14 days with spleen homogenate. Four strains of rickettsia-like organisms ...
Tópico(s): Mosquito-borne diseases and control
1973 - | Kansenshogaku zasshi
Noriko Suenaga, Ryozo Oishi, Takeo Fukuda,
The role of the central norepinephrine (NE) system, especially the locus coeruleus (LC), in the occurrence of decapitation convulsions was investigated in rats. Intraspinal injection of 6-hydroxydopamine (6-OHDA) caused a significant inhibition of decapitation convulsions as shown by prolongation of the latency and shortening of the convulsion's duration, as well as decreasing the NE content of the spinal cord to 35% of the control value without affecting the NE content of the various regions in the ...
Tópico(s): Neurogenesis and neuroplasticity mechanisms
1979 - Elsevier BV | Brain Research
"Hyuga" fever, reportedly caused by Rickettsia sennetsu, occurring in the west of Japan was suspected to be an endoparasite-borne rickettsiosis. No R. sennetsu, however, was detected in metacercariae found in the muscles of grey mullets (Mugil cephalus) ingested raw by most "Hyuga" fever patients. Instead, another neorickettsia-like organism (SF strain) was isolated occasionally from metacercariae of Stellantchasmus falcatus. A dog was inoculated with SF strain. It developed mild fever after an incubation ...
Tópico(s): Yersinia bacterium, plague, ectoparasites research
1981 - National Institute of Infectious Diseases | Japanese Journal of Medical Science and Biology
Takao Shimizu, Takeshi Koja, Tadashi Fujisaki, Takeo Fukuda,
We investigated the antinociceptive effects produced by peripheral electric stimulation (PES) in mice and the influence of administration of l-5-hydroxytryptophan (5-HTP), methysergide and naloxone on the antinociceptive effects of the PES. Administration of 5-HTP enhanced antinociceptive effects induced by PES, while methysergide and naloxone abolished this antinociception. The mechanisms of analgesia produced by PES involve both endogenous opiate systems and central serotonergic mechanisms.
Tópico(s): Neuroscience and Neural Engineering
1981 - Elsevier BV | Brain Research
Shingo Fujita, Toshiaki Shimizu, Kanji Izumi, Takeo Fukuda, M Sameshima, Norio Ohba,
Tópico(s): Intraocular Surgery and Lenses
1984 - Elsevier BV | Experimental Eye Research
Takao Shimizu, Shingo Fujita, Kanji Izumi, Takeshi Koja, Norio Ohba, Takeo Fukuda,
Tópico(s): Bioactive Compounds and Antitumor Agents
1984 - Springer Science+Business Media | Naunyn-Schmiedeberg s Archives of Pharmacology
Hiroshi Fukuzako, Hidefumi Tominaga, Kanji Izumi, Takeshi Koja, Masahiro Nomoto, Yoshiro Hokazono, Kenji Kamei, Hideo Fujii, Takeo Fukuda, Kei Matsumoto,
Postural myoclonus associated with long-term administration of neuroleptics was demonstrated in schizophrenic patients. Sixty patients who had been taking neuroleptics for more than 3 months were investigated for myoclonus and the relationships between postural myoclonus and age, duration of illness, duration of medication, current daily dose, cumulative dose, occurrence of abnormal finger movement, parkinsonism, and tardive dyskinesia were evaluated. Twenty-three patients (38%) showed postural myoclonus ...
Tópico(s): Parkinson's Disease Mechanisms and Treatments
1990 - Elsevier BV | Biological Psychiatry
Hidefumi Tominaga, Hiroshi Fukuzako, Kanji Izumi, Takeshi Koja, Takeo Fukuda, Hideo Fujii, Kohei Matsumoto, H. Sonoda, K. Imamura,
Tópico(s): Neuroendocrine Tumor Research Advances
1987 - Elsevier BV | The Lancet
Nobuhiro Koyama, Shigenobu Kojima, Takeo Fukuda, Tohru Nagamitsu, Tadashi Yasuhara, Satoshi Ōmura, Hiroshi Tomoda,
A new fungal metabolite designated calpinactam (1) was isolated from the culture broth of Mortierella alpina FKI-4905, and its structure was elucidated by spectroscopic analyses including NMR experiments. Calpinactam was found to be a hexapeptide with a caprolactam ring at its C-terminal. Its absolute stereochemistry was determined by amino acid analysis and total synthesis. Calpinactam selectively inhibited the growth of mycobacteria among various microorganisms. The MIC values of calpinactam against ...
Tópico(s): Fungal Biology and Applications
2009 - American Chemical Society | Organic Letters
Masahiro Irifune, Takao Shimizu, Masahiro Nomoto, Takeo Fukuda,
The role of the N-methyl-d-aspartate (NMDA) receptor-channel complex in ketamine-induced anesthesia was examined in mice. General anesthetic potencies were evaluated on a rating scale, which provided the data for anesthetic scores, loss of righting reflex, sleeping time and recovery time. All drugs were administered intraperitoneally. NMDA (60–300 mg/kg), an NMDA receptor agonist, dose-dependently antagonized the general anesthetic potencies of ketamine at a dose of 100 mg/kg which produced loss of ...
Tópico(s): Treatment of Major Depression
1992 - Elsevier BV | Brain Research
Takeo Fukuda, Kouhei Sugiyama, Shiho Arima, Yoshihiro Harigaya, Tohru Nagamitsu, Satoshi Ōmura,
The total synthesis of salinosporamide A has been achieved through enzymatic desymmetrization, diastereoselective aldol reaction, intramolecular aldol reaction, and intermolecular Reformatsky-type reaction followed by 1,4-reduction as key reactions.
Tópico(s): Marine Sponges and Natural Products
2008 - American Chemical Society | Organic Letters
Tohru Nagamitsu, Daisuke Takano, Kaori Marumoto, Takeo Fukuda, Kentaro Furuya, Kazuhiko Otoguro, Kazuyoshi Takeda, Isao Kuwajima, Yoshihiro Harigaya, Satoshi Ōmura,
The total synthesis of borrelidin has been achieved. The best feature of our synthetic route is macrocyclization at C11−C12 for the construction of an 18-membered ring after esterification between two segments. A detailed examination of the macrocyclization led us to the samarium(II) iodide-mediated intramolecular Reformatsky-type reaction as the most efficient synthetic approach. The two key segments were synthesized through regioselective methylation, directed hydrogenation, stereoselective Reformatsky- ...
Tópico(s): Catalytic C–H Functionalization Methods
2007 - American Chemical Society | The Journal of Organic Chemistry
S Iwata, Masahiro Nomoto, Takeo Fukuda,
We studied the effect of various kinds of β-adrenergic blockers on oxotremorine-, harmaline- and thyrotropin-releasing hormone (TRH)-induced tremors in mice. To investigate what property of β-blockers plays the main role in suppressing tremor, we employed five β-blockers (propranolol, atenolol, butoxamine, pindolol, and arotinolol). All drugs suppressed oxotremorine-induced tremors but none reduced harmaline-induced tremors. Even though TRH-induced tremors were decreased significantly only by propanolol ...
Tópico(s): Mitochondrial Function and Pathology
1993 - Elsevier BV | Pharmacology Biochemistry and Behavior
Masahiro Nomoto, Takeo Fukuda,
The effects of the selective and reversible MAOB inhibitor Ro19-6327 on parkinsonism in common marmosets, induced by MPTP were studied. Combined administration of Ro19-6327 with benserazide/levodopa potentiated the effects of levodopa to reverse akinesia. In a microdialysis study, the administration of Ro19-6327 was found to minimize the increase in metabolites of dopamine (DA) following injection of levodopa. These results suggest that Ro19-6327 suppresses the metabolism of DA, resulting in increased ...
Tópico(s): Neurological disorders and treatments
1993 - Elsevier BV | Neuropharmacology