The mechanism of anaerobic reduction of NO2− to N2O in a photodenitrifier, Rhodopseudomonas sphaeroides forma sp. denitrificans, was investigated. With ascorbate-reduced phenazine methosulfate (PMS) as the electron donor, the nitrite reductase of this photodenitrifier reduced NO2− to NO and a trace amount of N2O. With dithionite-reduced benzyl viologen as the electron donor, the major product of NO2− reduction was NH2OH, and a trace amount of N2O was also produced. The nitrate reductase itself had ...
Tópico(s): Photoreceptor and optogenetics research
1985 - Elsevier BV | Biochimica et Biophysica Acta (BBA) - General Subjects
Tatsushi Shiozawa, Shigeo URATA, Takeshi Kinoshita, Tamotsu Saitoh,
The structures of glycyrol (1) and isoglycyrol (4), which were isolated from the root of Glycyrrhiza, uralensis, were revised on the basis of a series of irradiation experiments.
Tópico(s): Plant-based Medicinal Research
1989 - Pharmaceutical Society of Japan | Chemical and Pharmaceutical Bulletin
Osamu Moriya, Yoshikiyo Urata, Takeshi Endo,
The reactions of hydroximic acid chlorides and organotin compounds such as bis(tributyltin) oxide or tetraphenyltin, whereby nitrile oxides are generated effectively, are applied to the preparations of isoxazolines and isoxazoles via[3 + 2] dipolar cycloaddition.
Tópico(s): Oxidative Organic Chemistry Reactions
1991 - Royal Society of Chemistry | Journal of the Chemical Society Chemical Communications
Osamu Moriya, Hideo Takenaka, M. Iyoda, Yoshikiyo Urata, Takeshi Endo,
Nitrite oxides were generated readily by the reaction of aldoximes 1, with tert-butyl hypochlorite and bis(tributyltin) oxide. The reaction proceeded efficiently under mild conditions, in which O-stannylated aldoximes 2 are thought to be key intermediates. This reaction system was applicable to the one-pot syntheses of isoxazole derivatives 4 and 5 in the presence of dipolarophiles via a [3 + 2] cycloaddition.
Tópico(s): Synthesis and Biological Evaluation
1994 - | Journal of the Chemical Society. Perkin transactions I/Journal of the Chemical Society. Perkin transactions. I
Shuzo Urata, Takeshi Noda, Yoshihiro Kawaoka, Shigeru Morikawa, Hideyoshi Yokosawa, Jiro Yasuda,
Marburg virus (MARV) VP40 is a matrix protein that can be released from mammalian cells in the form of virus-like particles (VLPs) and contains the PPPY sequence, which is an L-domain motif. Here, we demonstrate that the PPPY motif is important for VP40-induced VLP budding and that VLP production is significantly enhanced by coexpression of NP and GP. We show that Tsg101 interacts with VP40 depending on the presence of the PPPY motif, but not the PT/SAP motif as in the case of Ebola virus, and plays ...
Tópico(s): Hepatitis B Virus Studies
2007 - American Society for Microbiology | Journal of Virology
Shuzo Urata, Takeshi Noda, Yoshihiro Kawaoka, Hideyoshi Yokosawa, Jiro Yasuda,
ABSTRACT It is known that Lassa virus Z protein is sufficient for the release of virus-like particles (VLPs) and that it has two L domains, PTAP and PPPY, in its C terminus. However, little is known about the cellular factor for Lassa virus budding. We examined which cellular factors are used in Lassa virus Z budding. We demonstrated that Lassa Z protein efficiently produces VLPs and uses cellular factors, Vps4A, Vps4B, and Tsg101, in budding, suggesting that Lassa virus budding uses the multivesicular ...
Tópico(s): Viral Infections and Vectors
2006 - American Society for Microbiology | Journal of Virology
Toshiya Ochiai, Yoji Urata, Takeshi Yamano, Hisakazu Yamagishi, Tsukasa Ashihara,
Clonal analysis has shown that hepatocellular carcinoma arises from a single cell. However, the clonality of precancerous lesions and adjacent nonneoplastic tissues is not clear. We analyzed a human androgen receptor locus to elucidate the clonal state of liver tissues including post-hepatitic lesions associated with hepatocarcinogenesis. The analysis was based on a restriction fragment length polymorphism involving an androgen receptor locus on the X chromosome, taking advantage of physiologic ...
Tópico(s): Chromosomal and Genetic Variations
2000 - Lippincott Williams & Wilkins | Hepatology
Ryōichi Shikata, Yoshinori Urata, Takeshi Shiono, Tomozo NISHIKAWA,
Zirconia raw powder containing 2 or 3 mol% of Y2O3 prepared by a hydrolytic precipitation method and Al2O3 raw powder were mixed with ethanol using a pot-mill. The homogeneously mixed powder was mold-pressed at 35 MPa, and then, it was further isostatically pressed at 98 MPa. The moldings were sintered at 1300°-1600°C for 3 hr in air, and these densely sintered bodies were isostatically hot-pressed at 1450°or 1550°C for 1 hr in Ar under a pressure of 98 MPa.An addition of 20-40 wt% of Al2O3 to Y- ...
Tópico(s): Powder Metallurgy Techniques and Materials
1990 - | Journal of the Japan Society of Powder and Powder Metallurgy
Tetsuya Nomura, Masakazu Kikai, Yusuke Hori, Kenichi Yoshioka, Hiroshi Kubota, Daisuke Miyawaki, Ryota Urata, Takeshi Sugimoto, Natsuya Keira, Tetsuya Tatsumi,
Tópico(s): Cardiac Imaging and Diagnostics
2017 - Springer Science+Business Media | Cardiovascular Intervention and Therapeutics
Takatoshi Aoki, Tomohiko Kamimura, Shuro Yoshida, Yasuo Mori, Masanori Kadowaki, Kentaro Kohno, Daisuke Ishihara, Shingo Urata, Takeshi Sugio, Kenjiro Kamezaki, Koji Kato, Yoshikiyo Ito, Tetsuya Eto, Koichi Akashi, Toshihiro Miyamoto,
Vaccination against vaccine-preventable diseases (VPDs) is highly recommended for hematopoietic stem cell transplantation (HSCT) recipients by several guidelines; however, the safety and seropositivity after live attenuated vaccines remain unclear in adult HSCT recipients. We analyzed titers of antibodies against measles, rubella, mumps, and varicella zoster virus (VZV) from Japanese adult patients who underwent allogeneic HSCT (allo-HSCT) (n = 74), autologous HSCT (auto-HSCT) (n = 39), or chemotherapy (n = 93). ...
Tópico(s): Herpesvirus Infections and Treatments
2019 - Elsevier BV | Biology of Blood and Marrow Transplantation
Toshio Koizumi, Jun Sakamoto, Osamu Moriya, Yoshikiyo Urata, Nobukazu Yoshikawa, Takeshi Endo,
... and DithiolsToshio Koizumi, Jun Sakamoto, Osamu Moriya, Yoshikiyo Urata, Nobukazu Yoshikawa, and Takeshi EndoCite this: Macromolecules 1995, 28, 16, 5649–5654Publication ...
Tópico(s): Sulfur-Based Synthesis Techniques
1995 - American Chemical Society | Macromolecules
Osamu Moriya, Yoshikiyo Urata, Takeshi Endo,
O. Moriya, Y. Urata and T. Endo, J. Chem. Soc., Chem. Commun., 1991, 884 DOI: 10.1039/C39910000884
Tópico(s): Fluorine in Organic Chemistry
1991 - Royal Society of Chemistry | Journal of the Chemical Society Chemical Communications
Michiro Yamamoto, Hideo Yasunaga, Ryosuke Kakinoki, Naoto Tsubokawa, Akimasa Morita, Katsumi Tanaka, Akinori Sakai, Toshikazu Kurahashi, Hitoshi Hirata, Hitoshi Hirata, Masahiro Tatebe, Michiro Yamamoto, Tetsuro Onishi, Katsuyuki Iwatsuki, Katsuhiro Tokutake, Hideo Yasunaga, Ryosuke Kakinoki, Kazuhiro Otani, Naoto Tsubokawa, Akimasa Morita, Katsumi Tanaka, Akinori Sakai, Kunitaka Menuki, Yoshiaki Yamanaka, Shiro Urata, Takeshi Oguchi, Toshikazu Kurahashi, Norimasa Iwasaki, Yuichiro Matsui, Hiroyasu Ikegami, Hiroaki Sakano, Tetsu Katsumura, Masao Nishiwaki, Toshikazu Tanaka, Yuichi Hirasé, Yuri Kanno, Hiroyuki Kato, Masanori Hayashi, Shohei Omokawa, Hideo Hasegawa, Hiroyuki Gotani, Yoshitaka Tanaka, Toru Sunagawa, Rikuo Shinomiya, Rhoji Kajiwara, Etsuhiro Nakao, Takanobu Nishizuka, Yasunori Hattori, Takaaki Shinohara, Kentaro Watanabe, Nobuyuki Okui, Hiroshi Koshima, Tsuyoshi Tajika, Hiroyuki Ohi, Yoshio Kaji, Eiichi Nagayoshi, Ataru Igarashi,
Abstract This study compared hand function and the cost-effectiveness of treatment between collagenase Clostridium histolyticum (CCH) injection and limited fasciectomy for patients with Dupuytren’s contracture (DC). The CeCORD-J study is a prospective, multicenter, non-randomized controlled, observational study of two parallel groups. Participants were DC patients with multiple affected fingers, including flexion contracture of the proximal interphalangeal (PIP) joint. The primary outcome was the Hand10 ...
Tópico(s): Orthopedic Surgery and Rehabilitation
2022 - Nature Portfolio | Scientific Reports
Osamu Moriya, Yoshikiyo Urata, Yoshikazu Ikeda, Yoshio Ueno, Takeshi Endo,
... active methylene compounds via radical cyclizationOsamu Moriya, Yoshikiyo Urata, Yoshikazu Ikeda, Yoshio Ueno, and Takeshi EndoCite this: J. Org. Chem. 1986, 51, 24, ...
Tópico(s): Cyclopropane Reaction Mechanisms
1986 - American Chemical Society | The Journal of Organic Chemistry
Osamu Moriya, Hideo Takenaka, Yoshikiyo Urata, Takeshi Endo,
The reactions of O-tributylstannyl aldoximes and active halogen compounds such as tert-butyl hypochlorite or N-bromosuccinimide, whereby nitrile oxides are generated effectively, are applied to the preparations of isoxazolines and isoxazoles via[3 + 2] dipolar cycloaddition.
Tópico(s): Synthesis and Biological Evaluation
1991 - Royal Society of Chemistry | Journal of the Chemical Society Chemical Communications
Masaki Sakai, Atsushi Fukuda, H. Moriyama, M. Shimada, M. Urata, Takeshi Ohkuma, Y. Sato, Y. Iwata,
Development of ethylene-propylene rubber (EPR) insulation system has been advanced for a compact power lead of 66 kV-class high temperature superconducting fault current limiter (SCFCL). It is well known that insulation layers of superconducting cables are molded by extruding EPR containing inorganic filler. The power leads are not as long as the superconducting cables, making it difficult to mold their insulation layers by extrusion. When molding EPR by heat treatment, voids tend to remain in the ...
Tópico(s): HVDC Systems and Fault Protection
2000 - IEEE Council on Superconductivity | IEEE Transactions on Applied Superconductivity
A Shirota, Tetsuya Nomura, Hiroshi Kubota, Shunta Taminishi, Ryota Urata, Takeshi Sugimoto, Yusuke Higuchi, Taku Kato, Natsuya Keira, Tetsuya Tatsumi,
Because of the unusual anatomy of an anomalous origin of the right coronary artery from the left sinus of Valsalva, selective cannulation of the guiding catheter in percutaneous coronary intervention for these cases is always challenging.A 58-year-old Japanese man was admitted to our hospital complaining of worsening exertional chest pain. He was suspected of having unstable angina pectoris and underwent cardiac catheterization. We found a subtotal occlusive lesion in the mid-portion of his right ...
Tópico(s): Vascular anomalies and interventions
2015 - BioMed Central | Journal of Medical Case Reports
Fuyuki Ando, Hiromasa Tamaki, Yoko Matsumura, Tomoyuki Urata, Takeshi Kawabe, Ryosuke Yamamura, Yuriko Kaneko, Ryoji Funahashi, Tsutomu Kanno,
Studies on thermoelectric materials have been primarily centred on conversion efficiency, as if to assert a high-efficiency thermoelectric module always generates a large electrical power. However, there is a trade-off between conversion efficiency and power density under thermal and electrical energy losses due to contact resistances at electrode junctions. Thus, simultaneously boosting the power density and conversion efficiency ('dual-boost') is essential. Here, to overcome the trade-off by minimizing ...
Tópico(s): Phase-change materials and chalcogenides
2023 - Elsevier BV | Materials Today Physics
Daisuke Utsunomiya, Kazuo Awai, Takashi Sakamoto, Taiji Nishiharu, Joji Urata, Akira Taniguchi, Takeshi Nakaura, Yasuyuki Yamashita,
The purpose of this study was to determine the optimal contrast injection protocol for clear delineation of the endocardial and epicardial contours and coronary vessels in anatomic and functional imaging with cardiac 16-MDCT.Thirty-eight patients were allocated to three groups according to contrast injection protocol: a long-duration biphasic protocol in which diluted contrast material was used in the latter phase (protocol A, 13 patients); a uniphasic protocol with saline flush (protocol B, 12 patients); ...
Tópico(s): Medical Imaging Techniques and Applications
2006 - American Roentgen Ray Society | American Journal of Roentgenology
Yuko Urata, Wataru Yamashita, Takeshi Inoue, Kiyokazu Agata,
Adult newts can regenerate large parts of their brain from adult neural stem cells (NSCs), but how adult NSCs reorganize brain structures during regeneration remains unclear. In development, elaborate brain structures are produced under broadly coordinated regulations of embryonic NSCs in the neural tube, whereas brain regeneration entails exquisite control of the re-establishment of certain brain parts, suggesting that a yet-unknown mechanism directs NSCs upon partial brain excision. Here we report ...
Tópico(s): Developmental Biology and Gene Regulation
2018 - The Company of Biologists | Biology Open
Toshiya Ochiai, Yoji Urata, Takeshi Yamano, Teruhisa Sonoyama, Hisakazu Yamagishi, Tsukasa Ashihara,
A long-term survival case of multiple hepatocellular carcinoma (HCC) with metachronous metastasis to a lymph node is reported. The patient, a 66-year-old woman, had two primary HCC nodules, one each in the left and right hepatic lobes, which were resected. She developed a lymph node lesion and a secondary HCC 45 and 62 months after the first operation, respectively. She has been well for the 7 years since the first operation despite undergoing hepatic resection for HCC twice as well as lymph node ...
Tópico(s): Drug Transport and Resistance Mechanisms
2000 - Wiley | Hepatology Research
Kazuomi Kario, Kenta Okada, Mitsutoshi Kato, Masafumi Nishizawa, Tetsuro Yoshida, Tsuguyoshi Asano, Kazuaki Uchiyama, Yawara Niijima, Tomohiro Katsuya, Hidenori Urata, Jun-ichi Osuga, Takeshi Fujiwara, Shoji Yamazaki, Naoko Tomitani, Hiroshi Kanegae, Satoshi Hoshide, Mitsuyoshi Yamamoto, Katsumi Eguchi, Atsushi Mizuno, Shigeru Nakano, Yuta Kemi, Chie Iwashita, Kyouichi Wada, Azusa Kaneko, Nicola Ryan,
Background: The risk of cardiovascular disease and mortality in salt-sensitive patients with diabetes mellitus and uncontrolled nocturnal hypertension is high. The SACRA (Sodium-Glucose Cotransporter 2 [SGLT2] Inhibitor and Angiotensin Receptor Blocker [ARB] Combination Therapy in Patients With Diabetes and Uncontrolled Nocturnal Hypertension) study investigated changes in blood pressure (BP) with empagliflozin plus existing antihypertensive therapy. Methods: This multicenter, double-blind, parallel ...
Tópico(s): Sodium Intake and Health
2019 - Lippincott Williams & Wilkins | Circulation
Takayuki Fujii, Kei‐ichiro Takase, Hiroyuki Honda, Nobutoshi Kawamura, Ryo Yamasaki, Michiyo Urata, Takeshi Uchiumi, Toru Iwaki, Jun‐ichi Kira,
Oral nucleoside analogs (NAs) reduce hepatitis B virus (HBV) replication by inhibiting HBV DNA polymerase. However, NAs can also affect human mitochondrial DNA (mtDNA) polymerase, which can lead to mtDNA depletion (quantitative abnormality). Indeed, several mitochondrial myopathy cases have been reported in which a reduced mtDNA copy number was induced by oral NAs for hepatitis B. Herein, we report a case of toxic myopathy with multiple mtDNA deletions (qualitative abnormality) associated with long‐term ...
Tópico(s): Hepatitis B Virus Studies
2019 - Wiley | Neuropathology
Kunishige Kataoka, Ryosuke Sugiyama, Shun Hirota, M. Inoue, Kanae Urata, Yoichi Minagawa, Daisuke Seo, Takeshi Sakurai,
The mechanism of the four-electron reduction of dioxygen by a multicopper oxidase, CueO, was studied based on reactions of single and double mutants with Cys500, a type I copper ligand, and the noncoordinating Asp112 and Glu506, which form hydrogen bonds with the trinuclear copper center directly and indirectly via a water molecule. The reaction of C500S containing a vacant type I copper center produced intermediate I in an EPR-silent peroxide-bound form. The formation of intermediate I from C500S/ ...
Tópico(s): Metal complexes synthesis and properties
2009 - Elsevier BV | Journal of Biological Chemistry
K. Hoshi, Hiide Yoshino, Jungo Urata, Yosikazu Nakamura, Hiroshi Yanagawa, Takeshi Sato,
Article abstract A nationwide survey and recent information documented 57 patients with Creutzfeldt–Jakob disease (CJD) who had received dura mater grafts during the period between January 1979 and September 1999. At least 54 of these 57 patients received the same brand of dura mater graft from the same processor. Mean age at disease onset in the 57 patients with dural grafts was younger (51.9 years) than that in patients with sporadic CJD (63 years) ( p < 0.0001). Initial symptoms were cerebellar ataxia, disorientation, ...
Tópico(s): Alcoholism and Thiamine Deficiency
2000 - Lippincott Williams & Wilkins | Neurology
Joji Urata, Mitsue Miyazaki, Hirofumi Wada, Takeshi Nakaura, Yasuyuki Yamashita, Mutsumasa Takahashi,
Abstract The efficacy of the nonenhanced magnetic resonance angiography (MRA) technique known as fresh‐blood imaging (FBI), using electrocardiograph (ECG)‐triggered 3D half‐Fourier fast spin‐echo (FSE), was evaluated for the detection and characterization of aortic diseases. Seventy‐five consecutive patients with aortic disease underwent the FBI examination on a 1.5‐T clinical imager. The results showed that the FBI technique permits clear visualization of aortic diseases, and the vessel branches and ...
Tópico(s): Cerebrovascular and Carotid Artery Diseases
2001 - Wiley | Journal of Magnetic Resonance Imaging
Tetsuya Nomura, Yusuke Higuchi, Hiroshi Kubota, Daisuke Miyawaki, Ryota Urata, Takeshi Sugimoto, Taku Kato, Natsuya Keira, Tetsuya Tatsumi,
Objectives This study aimed to investigate the practical usefulness of dual lumen catheter‐facilitated reverse wire technique. Background We sometimes encounter difficulty in introducing a guidewire to the highly angulated side branch. In those cases, the reverse wire technique is considered as a last resort to overcome the situation. Methods Between January 2013 and June 2015, we performed the reverse wire technique for guidewire crossing into an extremely angulated side branch in consecutive seven ...
Tópico(s): Cardiac Imaging and Diagnostics
2015 - Wiley | Journal of Interventional Cardiology
Tetsuya Nomura, Taku Kato, Hiroshi Kubota, Daisuke Miyawaki, Ryota Urata, Takeshi Sugimoto, Yusuke Higuchi, Natsuya Keira, Tetsuya Tatsumi,
A lotus root appearance is a rare entity, and there is little opportunity to perform coronary intervention for this kind of lesion. Because of its peculiar anatomical characteristics, one of the problems regarding percutaneous coronary intervention (PCI) for these lesions is related to the involvement of branch vessels. We encountered a case of PCI for a stenotic lesion with a lotus root appearance in the mid-portion of the right coronary artery (RCA). To avoid the risk of right ventricular (RV) branch ...
Tópico(s): Cardiac Imaging and Diagnostics
2016 - BioMed Central | BMC Cardiovascular Disorders
Yasunori Nagayama, Shota Tanoue, Akinori Tsuji, Joji Urata, M Furusawa, Seitaro Oda, Takeshi Nakaura, Daisuke Utsunomiya, Eri Yoshida, Morikatsu Yoshida, Masafumi Kidoh, Machiko Tateishi, Yasuyuki Yamashita,
To evaluate the image quality, radiation dose, and renal safety of contrast medium (CM)-reduced abdominal-pelvic CT combining 80-kVp and sinogram-affirmed iterative reconstruction (SAFIRE) in patients with renal dysfunction for oncological assessment.We included 45 patients with renal dysfunction (estimated glomerular filtration rate 60 ml per lmin per 1.73 m2) who underwent standard oncological abdominal-pelvic CT (600 mgI kg-1, 120-kVp, filtered-back projection) were included as controls. CT attenuation, ...
Tópico(s): MRI in cancer diagnosis
2018 - Wiley | British Journal of Radiology
Shuzo Urata, Takeshi Ishikawa, Jiro Yasuda,
Ebola virus (EBOV) VP40 is a major driving force of nascent virion production and a negative regulator of genome replication/transcription. Here, we showed that the YIGL sequence at the C-terminus of EBOV VP40 is important for virus-like particle (VLP) production and the regulation of genome replication/transcription. Accordingly, a mutation in the YIGL sequence caused defects in VLP production and genome replication/transcription. The residues I293 and L295 in the YIGL sequence were particularly ...
Tópico(s): Viral Infections and Vectors
2019 - Microbiology Society | Journal of General Virology