... Science®Google Scholar 18 Kuwababa, N., Kondo, K., Taki, T., Inoue, T., Takagi, T. and Fukttda, Y.: Report of ...
Tópico(s): Cell Adhesion Molecules Research
1972 - | Acta Pathologica Japonica
Daisuke Hashimoto, Kota Arima, Naomi Yokoyama, Akira Chikamoto, Katsunobu Taki, Risa Inoue, Takayoshi Kaida, Takaaki Higashi, Hidetoshi Nitta, Masaki Ohmuraya, Masahiko Hirota, Toru Beppu, Hideo Baba,
Activating Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations are the most common and frequent changes observed in pancreatic cancer. This study aimed to determine the frequency and extent of intratumoral and metastatic lymph node KRAS mutation heterogeneity of resected pancreatic ductal adenocarcinoma.Tumor tissues macrodissected from tumor centers, invasion fronts (n = 97), and lymph nodes (n = 11) were subjected to DNA extraction and mutation analysis of KRAS codons 12 and 13 by pyrosequencing. ...
Tópico(s): Lung Cancer Research Studies
2016 - Lippincott Williams & Wilkins | Pancreas
Daisuke Hashimoto, Kota Arima, Akira Chikamoto, Katsunobu Taki, Risa Inoue, Takayoshi Kaida, Takaaki Higashi, Katsunori Imai, Toru Beppu, Hideo Baba,
The surgical management of duodenal pathology is challenging because of its retroperitoneal position and shared blood supply with the pancreas. We present three types of limited resection of the duodenum for the removal of superficial or small nonampullary duodenal (NADL) lesions, and also a review of the English literature regarding management, such as endoscopic resection and limited duodenal resection. Ten cases underwent limited resections of the duodenum for superficial or small NADL lesions ...
Tópico(s): Gastric Cancer Management and Outcomes
2016 - SAGE Publishing | The American Surgeon
Masaki Takiwaki, Fumihiro Tomoda, Tsutomu Koike, Tomohiko Taki, Hiroshi Inoue, Mika Kigawa, Isaso Kitajima, Yoshinori Uji,
Among subfractions of low-density lipoprotein cholesterol (LDL-C), small dense LDL-C (SdLDL-C) has been highlighted as the most atherogenic lipoprotein cholesterol. The present study aimed to compare the relationship of SdLDL-C with blood viscosity, a surrogate marker for cardiovascular disease, with that of other lipid fractions with blood viscosity in essential hypertensives (EHTs). In 128 untreated, early-stage EHTs, blood viscosity was measured with a falling-ball microviscometer, and serum levels ...
Tópico(s): Lipoproteins and Cardiovascular Health
2014 - Springer Nature | Hypertension Research
Makiko Nakayama, Hiroshi Keino, Annabelle A. Okada, Takayo Watanabe, Wakako Taki, Makoto Inoue, Akito Hirakata,
In Brief Purpose: Optical coherence tomography (OCT) using enhanced depth imaging (EDI) allows evaluation of choroidal thickness. Our objective was to analyze subfoveal choroidal thickness by EDI-OCT before and after the initiation of high-dose corticosteroid treatment in 8 patients (16 eyes) with new-onset acute Vogt–Koyanagi–Harada (VKH) disease. Methods: Retrospective review of clinical records. Results: The outer border of the choroid was not evident by EDI-OCT in any patients at presentation. Subfoveal ...
Tópico(s): Ocular Infections and Treatments
2012 - Lippincott Williams & Wilkins | Retina
Hisatomo Taki, Takenari Inoue, Hiroshi Tanaka, Hiroshi Makihara, Masahiro Sueyoshi, Masahiro Isono, Kimiko Okabe,
Identifying effective management operations for plantations is important for conservation of biodiversity in a plantation-dominated landscape. We tested whether pre-commercial thinning influenced community structures and could be an effective strategy for increasing diversity and abundance of plants and animals in plantations. We designated thinned and unthinned study stands in Japanese cedar (Cryptomeria japonica) plantations and compared the communities of understory vegetation, bees, butterflies, ...
Tópico(s): Forest Ecology and Biodiversity Studies
2009 - Elsevier BV | Forest Ecology and Management
Hiroshi Orihara, Akio Taki, Masao Doi, Akio Inoue,
... Icon Cite Search Site Citation Hiroshi Orihara, Akio Taki, Masao Doi, Akio Inoue; Electrorheological properties of a mixture of two immiscible ...
Tópico(s): Fluid Dynamics and Vibration Analysis
2001 - American Institute of Physics | Journal of Rheology
Motohiro Kato, Toshihiko Imamura, Atsushi Manabe, Yoshiko Hashii, Katsuyoshi Koh, Atsushi Satō, Hiroyuki Takahashi, Hiroki Hori, Tomohiko Taki, Masami Inoue, Yasuhide Hayashi, Keizo Horibe, Masahiro Tsuchida, Seiji Kojima, Megumi Oda, Akira Ohara,
The British Journal of Haematology publishes original research papers in clinical, laboratory and experimental haematology. The Journal also features annotations, reviews, short reports, images in haematology and Letters to the Editor.
Tópico(s): Chronic Myeloid Leukemia Treatments
2014 - Wiley | British Journal of Haematology
Masahiro Shibata, Kentaro Yoshimura, Hirosumi Tamura, Takashi Ueno, Taki Nishimura, Takao Inoue, Mitsuho Sasaki, Masato Koike, Hiroyuki Arai, Eiki Kominami, Yasuo Uchiyama,
The cytoplasmic lipid droplet (LD) is one of organelles that has a neutral lipid core with a single phospholipid layer. LDs are believed to be generated between the two leaflets of the endoplasmic reticulum (ER) membrane and to play various roles, such as high effective energy storage. However, it remains largely unknown how LDs are generated and grow in the cytoplasm. We have previously shown that the Atg conjugation system that is essential for autophagosome formation is involved in LD formation ...
Tópico(s): Endoplasmic Reticulum Stress and Disease
2010 - Elsevier BV | Biochemical and Biophysical Research Communications
Taki Nishimura, Takao Inoué, Norihito Shibata, Azusa Sekine, Wakako Takabe, Noriko Noguchi, Hiroyuki Arai,
25-hydroxycholesterol (25-HC) is a potent suppressor of cholesterol synthesis gene transcription in cultured cells. A high affinity binding protein for 25-HC, oxysterol-binding protein (OSBP), has been identified from tissue cytosol. OSBP translocates from the cytosol to the Golgi apparatus membranes after addition of 25-HC to cell cultures and is thought to mediate 25-HC action on cholesterol metabolism through association to the Golgi apparatus. However, direct evidence to prove this hypothesis ...
Tópico(s): Peroxisome Proliferator-Activated Receptors
2005 - Wiley | Genes to Cells
Daisuke Hashimoto, Akira Chikamoto, Kota Arima, Katsunobu Taki, Risa Inoue, Katsunori Imai, Yo‐ichi Yamashita, Hideo Baba,
Abstract Background The incidence of incisional surgical site infection (SSI) after pancreatic surgery remains high. The aim of this study was to assess the effectiveness of the unused sterile instruments that were not used throughout the course of surgery and were opened exactly at the moment of wound closure to prevent incisional SSI after open pancreatic surgery. Materials and methods We retrospectively evaluated the incidence of incisional SSI and the clinical course in 203 patients who underwent pancreatic ...
Tópico(s): Hemostasis and retained surgical items
2016 - Elsevier BV | Journal of Surgical Research
Shintaro Taki, Haruhiko Kamada, Masaki Inoue, Nagano Kazuya, Yohei Mukai, Kazuma Higashisaka, Yasuo Yoshioka, Yasuo Tsutsumi, Shin‐ichi Tsunoda,
Ephrin receptor A10 (EphA10), a transmembrane receptor that binds to ephrin, is a newly identified breast cancer marker protein that has also been detected in HER2-negative tissue. In this study, we report creation of a novel bispecific antibody (BsAb) binding both EphA10 and CD3, thereby forming a bridge between antigens expressed on both tumor and immune cells and promoting recognition of tumor cells by immune cells and redirection of cytotoxic T cells (CTL). This BsAb (EphA10/CD3) was expressed in ...
Tópico(s): Immunotherapy and Immune Responses
2015 - Public Library of Science | PLoS ONE
Haruhiko Kamada, Shintaro Taki, Kazuya Nagano, Masaki Inoue, Daisuke Ando, Yohei Mukai, Kazuma Higashisaka, Yasuo Yoshioka, Yasuo Tsutsumi, Shin‐ichi Tsunoda,
The EPH receptor A10 (EphA10) is up-regulated in breast cancer but is not normally expressed in healthy tissue, thus it has been suggested that EphA10 may be a useful target for cancer therapy. This study reports a diabody, an antibody derivative binding two different target molecules, EphA10 expressed in tumor cells and CD3 expressed in T cells, which showed T cell dependent-cytotoxicity. The diabody, which has His-tagged and FLAG-tagged chains, was expressed in Escherichia coli and purified in ...
Tópico(s): Receptor Mechanisms and Signaling
2014 - Elsevier BV | Biochemical and Biophysical Research Communications
Yoshiyuki Tanaka, Yasuhiro Kasai, S. Mochizuki, Akihiro Wakisaka, Eugene Hayato Morita, Chojiro Kojima, Atsushi Toyozawa, Yoshinori Kondo, Masumi Taki, Yasuomi Takagi, Atsushi Inoue, Kazuhiko Yamasaki, Kazunari Taira,
We have studied the interaction between metal ions and the metal ion-binding motif in hammerhead ribozymes, as well as the functions of the metal ion at the motif, with heteronuclear NMR spectroscopy. In this study, we employed model RNA systems which mimic the metal ion-binding motif and the altered motif. In Co(NH3)6(III) titrations, we observed large 1H and 31P chemical shift perturbations for the motif and found that outer-sphere complexation of Co(NH3)6(III) is possible for this motif. From ...
Tópico(s): DNA and Nucleic Acid Chemistry
2004 - American Chemical Society | Journal of the American Chemical Society
Masumi Taki, Hiroaki Inoue, Kazuto Mochizuki, Jay Yang, Yuji Ito,
To obtain a molecular probe for specific protein detection, we have synthesized fluorogenic probe library of vast diversity on bacteriophage T7 via the gp10 based-thioetherificaion (10BASE(d)-T). A remarkable color-changing and turning-on probe was selected from the library, and its physicochemical properties upon target-specific binding were obtained. Combination analyses of fluorescence emission titration, isothermal titration calorimetry (ITC), and quantitative saturation-transfer difference (STD) ...
Tópico(s): Bacteriophages and microbial interactions
2016 - American Chemical Society | Analytical Chemistry
Teruhiko Matsubara, Ai Onishi, Tomomi Saito, Aki Shimada, Hiroki Inoue, Takao Taki, Kyosuke Nagata, Yoshio Okahata, Toshinori Sato,
Influenza is an infectious disease caused by the influenza virus, and each year many people suffer from this disease. Hemagglutinin (HA) in the membrane of type A influenza viruses recognizes sialylglycoconjugate receptors on the host cell surface at an initial step in the infection process; consequently, HA inhibitors are considered potential candidates for antiviral drugs. We identified peptides that bind to receptor-binding sites through a multiple serial selection from phage-displayed random ...
Tópico(s): Glycosylation and Glycoproteins Research
2010 - American Chemical Society | Journal of Medicinal Chemistry
Hidenobu Terai, Masami Shimizu, Hidekazu Ino, Masato Yamaguchi, Kenshi Hayashi, Kenji Sakata, Masaru Kiyama, Tatsumi Hayashi, Masaru Inoue, Junichi Taki, Hiroshi Mabuchi,
Tópico(s): Cardiac Arrhythmias and Treatments
2003 - Springer Science+Business Media | Journal of Nuclear Cardiology
Takao Taki, Tania Valdes Gonzalez, Naoko Goto‐Inoue, Takahiro Hayasaka, Mitsutoshi Setou,
A simple method for transfer of lipids including phospholipids, glycolipids, and neutral lipids from a high-performance thin-layer chromatography (HPTLC) plate to a polyvinylidene difluoride (PVDF) membrane, called TLC blot (far-eastern blot), is presented. Lipids separated on a HPTLC plate are blotted quantitatively. This procedure made it possible to purify individual lipids from a blotted membrane in a short time. Binding study, immunodetection, and mass spectrometric analysis are available for ...
Tópico(s): Metabolism and Genetic Disorders
2009 - Springer Science+Business Media | Methods in molecular biology
Yohko U. Katagiri, Ban Sato, Kenji Yamatoya, Takao Taki, Naoko Goto‐Inoue, Mitsutoshi Setou, Hajime Okita, Junichiro Fujimoto, Chizuru Ito, Kiyotaka Toshimori, Nobutaka Kiyokawa,
Tópico(s): Erythrocyte Function and Pathophysiology
2011 - Elsevier BV | Biochemical and Biophysical Research Communications
Takuya Sakamoto, Ryohei Imasaka, Hirofumi Taki, Toru Sato, Mototaka Yoshioka, K. Inoue, Takeshi Fukuda, Hiroyuki Sakai,
The objectives of this paper are to propose a method that can accurately estimate the human heart rate (HR) using an ultrawideband (UWB) radar system, and to determine the performance of the proposed method through measurements. The proposed method uses the feature points of a radar signal to estimate the HR efficiently and accurately. Fourier- and periodicity-based methods are inappropriate for estimation of instantaneous HRs in real time because heartbeat waveforms are highly variable, even within ...
Tópico(s): Heart Rate Variability and Autonomic Control
2015 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Biomedical Engineering
Takuya Sakamoto, Shigeaki Okumura, Ryosuke Imanishi, Hirofumi Taki, Toru Sato, Mototaka Yoshioka, K. Inoue, Takeshi Fukuda, Hiroyuki Sakai,
Measurement of heartbeats is essential in cardiovascular magnetic resonance imaging because the measurement must be synchronized with the phase of cardiac cycles. Many existing studies on radar-based heartbeat monitoring have focused on echoes from the torso only, and such monitoring cannot be applied to subjects in magnetic resonance scanners because only the head and soles can be seen from the outside. In this study, we demonstrate the feasibility of the remote monitoring of heartbeats from the ...
Tópico(s): Hemodynamic Monitoring and Therapy
2015 - Institute of Electronics, Information and Communication Engineers | IEICE Electronics Express
Takuya Sakamoto, Ryohei Imasaka, Hirofumi Taki, Toru Sato, Mototaka Yoshioka, K. Inoue, Takeshi Fukuda, Hiroyuki Sakai,
We demonstrate an accurate remote measurement of heartbeats using an ultra-wideband radar system. Although most conventional systems use either continuous waves or impulse-radio systems for remote vital monitoring, continuous waves suffer from non-stationary clutters, while impulse-radio systems cannot detect heartbeats. Our ultra-wideband radar system has a moderate fractional bandwidth intermediate of these systems, resulting in both the suppression of clutters and high sensitivity in measuring ...
Tópico(s): ECG Monitoring and Analysis
2015 - Institute of Electronics, Information and Communication Engineers | IEICE Electronics Express
Nanami Senoo, Noriyuki Miyoshi, Naoko Goto‐Inoue, Kimiko Minami, Ryoji Yoshimura, Akihito Morita, Naoki Sawada, Junichiro Matsuda, Yoshihiro Ogawa, Mitsutoshi Setou, Yasutomi Kamei, Shinji Miura,
... TLC-blot method, as described previously (31.Goto-Inoue N. Hayasaka T. Taki T. Gonzalez T.V. Setou M. A new ...
Tópico(s): Peroxisome Proliferator-Activated Receptors
2015 - Elsevier BV | Journal of Lipid Research
Hisatomo Taki, Isamu Okochi, Kimiko Okabe, Takenari Inoue, Hideaki Goto, Takeshi Matsumura, S. Makino,
In many temperate terrestrial forest ecosystems, both natural human disturbances drive the reestablishment of forests. Succession in plant communities, in addition to reforestation following the creation of open sites through harvesting or natural disturbances, can affect forest faunal assemblages. Wild bees perform an important ecosystem function in human-altered and natural or seminatural ecosystems, as they are essential pollinators for both crops and wild flowering plants. To maintain high abundance ...
Tópico(s): Plant Parasitism and Resistance
2013 - Public Library of Science | PLoS ONE
Kai Wu, Yasuyuki Taki, Kazunori Sato, Yuko Sassa, Kentaro Inoue, Ryoi Goto, Ken Okada, Ryuta Kawashima, Yong He, Alan C. Evans, Hiroshi Fukuda,
Community structure is a universal and significant feature of many complex networks in biology, society, and economics. Community structure has also been revealed in human brain structural and functional networks in previous studies. However, communities overlap and share many edges and nodes. Uncovering the overlapping community structure of complex networks remains largely unknown in human brain networks. Here, using regional gray matter volume, we investigated the structural brain network among ...
Tópico(s): EEG and Brain-Computer Interfaces
2011 - Public Library of Science | PLoS ONE
Yasuyuki Taki, Shigeo Kinomura, Kazunori Sato, Kentaro Inoue, Ryoi Goto, Ken Okada, Shinya Uchida, Ryuta Kawashima, Hiroshi Fukuda,
Objective: To investigate any correlation between BMI and brain gray matter volume, we analyzed 1,428 healthy Japanese subjects by applying volumetric analysis and voxel‐based morphometry (VBM) using brain magnetic resonance (MR) imaging, which enables a global analysis of brain structure without a priori identification of a region of interest. Methods and Procedures: We collected brain MR images from 690 men and 738 women, and their height, weight, and other clinical information. The collected images ...
Tópico(s): Advanced Neuroimaging Techniques and Applications
2008 - Wiley | Obesity
Yasuyuki Taki, Shigeo Kinomura, Shuichi Awata, Kentaro Inoue, Kazunori Sato, Hiroshi Ito, Ryoi Goto, Shinya Uchida, Ichiro Tsuji, Hiroyuki Arai, Ryuta Kawashima, Hiroshi Fukuda,
The brain morphological changes in subthreshold depression (sD) have not been clarified. We examined the structural difference in regional gray matter volume between community-dwelling elderly subjects with sD and age-matched nondepressed normal subjects by voxel-based morphometry (VBM) based on magnetic resonance imaging (MRI). Thirty-four community-dwelling elderly subjects with sD and 109 age-matched nondepressed normal subjects were studied by MRI. We defined subjects with sD as those who showed ...
Tópico(s): Treatment of Major Depression
2005 - Elsevier BV | Journal of Affective Disorders
Hisatomo Taki, Yuichi Yamaura, Isamu Okochi, Takenari Inoue, Kimiko Okabe, S. Makino,
Abstract. 1. Tree harvesting, an anthropogenic disturbance, and natural disturbances, such as avalanches, windstorms, fires, and floods, drive forest reestablishment. Chrono‐sequential changes in plant communities as well as reforestation caused by harvesting and natural disturbances can affect forest faunal assemblages. 2. The effects of reforestation age, from recently harvested to old growth between 1 and 178 years old, on moth assemblages were examined for two types of reforestation: plantations ...
Tópico(s): Fire effects on ecosystems
2010 - Wiley | Insect Conservation and Diversity
Osamu Udagawa, Chizuru Ito, Narumi Ogonuki, Hiroyasu Sato, Shoken Lee, Pearlta Tripvanuntakul, Ikuyo Ichi, Y. Uchida, Taki Nishimura, Makoto Murakami, Atsuo Ogura, Takao Inoué, Kiyotaka Toshimori, Hiroyuki Arai,
Oligo-astheno-teratozoospermia (OAT), a condition that includes low sperm number, low sperm motility and abnormal sperm morphology, is the commonest cause of male infertility. Because genetic analysis is frequently impeded by the infertility phenotype, the genetic basis of many of OAT conditions has been hard to verify. Here, we show that deficiency of ORP4, a sterol-binding protein in the oxysterol-binding protein (OSBP)-related protein family, causes male infertility due to severe OAT in mice. In ...
Tópico(s): Cholesterol and Lipid Metabolism
2013 - Wiley | Genes to Cells
Terence J. Quinn, Kennedy R. Lees,
... CrossrefMedlineGoogle Scholar7 Ogawa A, Mori E, Minematsu E, Taki W, Takahashi A, Nemoto S, Miyamoto S, Sasaki M, Inoue T; for The MELT Japan Study Group. Randomized ...
Tópico(s): Health Systems, Economic Evaluations, Quality of Life
2008 - Lippincott Williams & Wilkins | Stroke