Daisuke Toritsuka, Masaya Aoki, Akihiko Higashida, Kazuaki Fukahara, Naonori Nishida, Keiichi Hirono, Mai Hane, Takuya Sugimoto, Takashi Asahara, Naoki Yoshimura,
Abstract OBJECTIVES Intestinal ischaemia–reperfusion injury induced by cardiopulmonary bypass causes intestinal epithelial barrier dysfunction, leading to dysbiosis and bacterial translocation. We conducted a randomized prospective study with 2 objectives: (i) to investigate epithelial barrier dysfunction and bacterial translocation induced by cardiopulmonary bypass and changes in the gut microbiota and (ii) to verify whether probiotics can improve these conditions. METHODS Between 2019 and 2020, ...
Tópico(s): Gut microbiota and health
2024 - Oxford University Press | European Journal of Cardio-Thoracic Surgery
Michio Okamoto, Rei Mizuno, Kenji Kawada, Yoshiro Itatani, Yoshiyuki Kiyasu, Keita Hanada, Wataru Hirata, Yasuyo Nishikawa, Hideyuki Masui, Naoko Sugimoto, Takuya Tamura, Susumu Inamoto, Yoshiharu Sakai, Kazutaka Obama,
Neutrophil extracellular traps (NETs) play important roles in host immunity, as there is increasing evidence of their contribution to the progression of several types of cancers even though their role in colorectal cancers (CRCs) remains unclear. To investigate the clinical relevance of NETs in CRCs, we examined the expression of citrullinated histone H3 using immunohistochemistry and preoperative serum myeloperoxidase-DNA complexes in CRC patients using an enzyme-linked immunosorbent assay. High ...
Tópico(s): Cell Adhesion Molecules Research
2023 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Hideki T. Miyazaki, Takaaki Mano, Takeshi Kasaya, Hirotaka Osato, Kazuhiro Watanabe, Yoshimasa Sugimoto, Takuya Kawazu, Yukinaga Arai, Akitsu Shigetou, Tetsuyuki Ochiai, Yoji Jimba, Hiroshi Miyazaki,
Abstract Optical patch antennas sandwiching dielectrics between metal layers have been used as deep subwavelength building blocks of metasurfaces for perfect absorbers and thermal emitters. However, for applications of these metasurfaces for optoelectronic devices, wiring to each electrically isolated antenna is indispensable for biasing and current flow. Here we show that geometrically engineered metallic wires interconnecting the antennas can function to synchronize the optical phases for promoting ...
Tópico(s): Photonic and Optical Devices
2020 - Nature Portfolio | Nature Communications
Mel F. Hainey, Takaaki Mano, Takeshi Kasaya, Tetsuyuki Ochiai, Hirotaka Osato, Kazuhiro Watanabe, Yoshimasa Sugimoto, Takuya Kawazu, Yukinaga Arai, Akitsu Shigetou, Hideki T. Miyazaki,
Abstract Two photodetectors for measuring transmission and two bulky, separated narrowband filters for picking a target gas absorption line and a non-absorbing reference from broadband emission are typically required for dual-band non-dispersive infrared (NDIR) gas sensing. Metal-dielectric-metal (MDM) metasurface plasmon cavities, precisely controllable narrowband absorbers, suggest a next-generation, nanophotonic approach. Here, we demonstrate a dual-band MDM cavity detector that consolidates the ...
Tópico(s): Spectroscopy and Laser Applications
2020 - De Gruyter | Nanophotonics
Eri Wakai, Kenji Ikemura, Hiroko Sugimoto, Takuya Iwamoto, Masahiro Okuda,
Magnesium oxide (MgO), an antacid and laxative, is widely used in Japan to treat constipation and peptic ulcers. Because serum Magnesium (Mg) levels are elevated in elderly and/or patients with renal failure, its periodic monitoring is recommended for patients prescribed MgO, in order to prevent MgO-induced hypermagnesemia. However, there is little information regarding the factors contributing to the development of MgO-induced hypermagnesemia. In the present study, we retrospectively investigated ...
Tópico(s): Parathyroid Disorders and Treatments
2019 - BioMed Central | Journal of Pharmaceutical Health Care and Sciences
Hirotoshi Matsumura, Kiwamu Umezawa, K. Takeda, Naohisa Sugimoto, Takuya Ishida, Masahiro Samejima, Hiroyuki Ohno, Makoto Yoshida, Kiyohiko Igarashi, Nobuhumi Nakamura,
Pyrroloquinoline quinone (PQQ) is a redox cofactor utilized by a number of prokaryotic dehydrogenases. Not all prokaryotic organisms are capable of synthesizing PQQ, even though it plays important roles in the growth and development of many organisms, including humans. The existence of PQQ-dependent enzymes in eukaryotes has been suggested based on homology studies or the presence of PQQ-binding motifs, but there has been no evidence that such enzymes utilize PQQ as a redox cofactor. However, during ...
Tópico(s): Metal-Catalyzed Oxygenation Mechanisms
2014 - Public Library of Science | PLoS ONE
Taizo Kobayashi, Hiroshi Yamaguchi, Zacharie Jehl Li‐Kao, H. Sugimoto, Takuya Kato, H. Hakuma, Tokio Nakada,
Abstract In this work, the impacts of surface sulfurization of high‐quality Cu(In 1−x ,Ga x )Se 2 (CIGS) thin films deposited by three‐stage process on the film properties and the cell performance were investigated. The CIGS thin films were sulfurized at 550 °C for 30 min using H 2 S gas. The X‐ray photoelectron spectroscopy analysis revealed that sulfur atoms diffused into the CIGS surface layer and that the valence band minimum was lowered by the film sulfurization. The open circuit voltage ( V oc ) drastically ...
Tópico(s): Copper-based nanomaterials and applications
2014 - Wiley | Progress in Photovoltaics Research and Applications
Jidong Cheng, Hiroko Morisaki, Keiko Toyama, N. Sugimoto, Takuya Shintani, Andreas Tandelilin, Tetsuaki Hirase, Edward W. Holmes, Takayuki Morisaki,
Insulin resistance is one of the hallmark manifestations of obesity and Type II diabetes and reversal of this pathogenic abnormality is an attractive target for new therapies for Type II diabetes. A recent report that metformin, a drug known to reverse insulin resistance, demonstrated in vitro the metformin can inhibit AMP deaminase (AMPD) activity. Skeletal muscle is one of the primary organs contributing to insulin resistance and that the AMPD1 gene is selectively expressed at high levels in skeletal ...
Tópico(s): Pancreatic function and diabetes
2014 - BioMed Central | BMC Endocrine Disorders
Shinya Hasegawa, Takayuki Sugimoto, Takuya Hashimoto,
Structural phase transitions in SrZrO3, which is the mother phase of proton-conducting oxide, have been investigated with a combination of differential scanning calorimetry (DSC), high-temperature X-ray diffraction and dilatometry. In the DSC curve, reversible thermal anomalies due to phase transition were observed at 769 °C, 846 °C and 1102 °C. The phase transitions have been concluded to be of second-order, first-order and second-order at 769 °C, 846 °C and 1102 °C, respectively. From the baseline shift, ...
Tópico(s): Magnetic and transport properties of perovskites and related materials
2010 - Elsevier BV | Solid State Ionics
Hiroko Sugimoto, Takuya Iwamoto, Yukiko Murashima, Tsutomu Tabata, Norimasa Sagawa, Masahiro Okuda,
Tópico(s): Chemotherapy-related skin toxicity
2010 - Springer Science+Business Media | Cancer Chemotherapy and Pharmacology
Kohei Miyata, Tetsuya Nakagawa, Ryuhei Kawakami, Yuki Kita, Katsufumi Sugimoto, Takuya Nakashima, Takashi Harada, Tsuyoshi Kawai, Yasuchika Hasegawa,
Abstract The distorted coordination structures and luminescence properties of novel lanthanide complexes with oxo‐linked bidentate phosphane oxide ligands—4,5‐bis(diphenylphosphoryl)‐9,9‐dimethylxanthene (xantpo), 4,5‐bis(di‐ tert ‐butylphosphoryl)‐9,9‐dimethylxanthene ( t Bu‐xantpo), and bis[(2‐diphenylphosphoryl)phenyl] ether (dpepo)—and low‐vibrational frequency hexafluoroacetylacetonato (hfa) ligands are reported. The lanthanide complexes exhibit characteristic square antiprism and trigonal dodecahedron ...
Tópico(s): Organometallic Complex Synthesis and Catalysis
2010 - Wiley | Chemistry - A European Journal
Hiroki Mori, Toru Ikegami, Satoru Imura, Mitsuo Shimada, Yuji Morine, Hirofumi Kanemura, Yusuke Arakawa, Mami Kanamoto, Jun Hanaoka, Koji Sugimoto, Takuya Tokunaga,
A sclerosed hemangioma of the liver is an extremely rare type of benign hepatic tumor. A 77-year-old female was referred to Tokushima University Hospital with fever, abnormal liver function tests and a large liver mass. The tumor, 10 x 5 cm in size and located in segment 5-6 of the liver, was depicted as a low density tumor with enhancement by computed tomography (CT). Magnetic resonance imaging (MRI) showed it to be a tumor with a low signal on T1-weighted and a high signal on T2-weighted images. ...
Tópico(s): Medical Imaging and Pathology Studies
2007 - Wiley | Hepatology Research
Hiroyoshi Kodama, Satoru Momose, T. Sugimoto, Takuya Uzumaki, Atsushi Tanaka,
We have examined the magnetic anisotropy of the "heat-treated FePt nanoparticles" annealed in a magnetic field. The magnetic easy axis of the "heat-treated FePt nanoparticles" is found to be three-dimensional (3-D) random and a partial ordering fct structure is observed before annealing in the presence of a magnetic field. The value of M/sub r//M/sub s/ obtained is 0.5. After annealing in the presence of a magnetic field, the M-H loop indicates that the easy axis is oriented preferably in the perpendicular ...
Tópico(s): Characterization and Applications of Magnetic Nanoparticles
2005 - IEEE Magnetics Society | IEEE Transactions on Magnetics
Wilson Agerico Diño, Hiroshi Nakanishi, Hideaki Kasai, Tsuyoshi Sugimoto, Takuya Kondo,
Based on the density functional theory, we investigate and discuss how hydrogen behaves at the edges of graphite sheets/layers, in particular the zigzag edge. Our calculation results show that the zigzag edge is very reactive. It is possible to dissociatively adsorb H2 on these surfaces without any activation barrier hindering the reaction. To be able to use carbon nanomaterials as a means to store hydrogen, one of the crucial factors necessary would be the ability to dissociate hydrogen first, ...
Tópico(s): Graphite, nuclear technology, radiation studies
2004 - Japan Society of Vacuum and Surface Science | e-Journal of Surface Science and Nanotechnology
Wilson Agerico Diño, Yoshio Miura, Hiroshi Nakanishi, Hideaki Kasai, Tsuyoshi Sugimoto, Takuya Kondo,
We investigate and discuss how hydrogen behaves at the edges of a graphite sheet, in particular the armchair edge. Our density functional theory-based calculations results show that, in contrast to the zigzag edge [W.A. Diño, H. Nakanishi, H. Kasai, T. Sugimoto, T. Kondoe, e-J. Surf. Sci. Nanotech. 2 (2004) 77. [25]], regardless of orientation, there is an activation barrier hindering H2 dissociation at the armchair edges. And once they do get dissociatively adsorbed at the armchair edges, we find ...
Tópico(s): Advanced Chemical Physics Studies
2004 - Elsevier BV | Solid State Communications
Hideki Sugimoto, Takuya Takahira, Takashi Yoshimura, Motoo Shiro, Mikio Yamasaki, Hiroyuki Miyake, Keisuke Umakoshi, Yōichi Sasaki,
An oxo-bridged dirhenium(III,III) complex of tris(2-pyridylmethyl)amine (tpa) and its one-electron oxidized (III,IV) species, [Re2(μ-O)Cl2(tpa)2]3+,4+ have been prepared. They are new members to a series of rhenium tpa complexes in various oxidation states. X-ray structural determination of the Re2(III,IV) complex revealed practically linear ReORe bridge (178(1)°) with short ReO distances of 1.85(2) Å indicative of some multiple bonded character. The 1H NMR spectrum disclosed the relatively slow ...
Tópico(s): Molecular Junctions and Nanostructures
2002 - Elsevier BV | Inorganica Chimica Acta
Kenji Kabashima, Tomomi Saji, Tatsunori Murata, Miyako Nagamachi, Toshiyuki Matsuoka, Eri Segi‐Nishida, Kazuhito Tsuboi, Yukihiko Sugimoto, Takuya Kobayashi, Yoshiki Miyachi, Atsushi Ichikawa, Shuh Narumiya,
We used mice deficient in each of the eight types and subtypes of prostanoid receptors and examined the roles of prostanoids in dextran sodium sulfate–induced (DSS-induced) colitis. Among the prostanoid receptor–deficient mice, only EP4-deficient mice and not mice deficient in either DP, EP1, EP2, EP3, FP, IP, or TP developed severe colitis with 3% DSS treatment, which induced only marginal colitis in wild-type mice. This phenotype was mimicked in wild-type mice by administration of an EP4-selective ...
Tópico(s): NF-κB Signaling Pathways
2002 - American Society for Clinical Investigation | Journal of Clinical Investigation
Tsuyoshi Sugimoto, Takuya Akiyama, Yuji Matsumoto, Gyosuke Meshitsuka,
Summary The ozonation method was applied to an analysis of the changes in erythro and threo (E/T) ratio of arylglycerol-β-aryl ether (β-O-4) structures in the residual lignins of delignified wood samples. When delignified by alkali cook, not only the total yield of erythronic and threonic acids per lignin decreased, but also the E/T ratio decreased with the progress of delignification. These results indicate that residual lignin of alkali-delignified wood contain only a small amount of arylglycerol- ...
Tópico(s): Enzyme-mediated dye degradation
2002 - De Gruyter | Holzforschung
Kenji Kabashima, Tomomi Saji, Tatsunori Murata, Miyako Nagamachi, Toshiyuki Matsuoka, Eri Segi‐Nishida, Kazuhito Tsuboi, Yukihiko Sugimoto, Takuya Kobayashi, Yoshiki Miyachi, Atsushi Ichikawa, Shuh Narumiya,
We used mice deficient in each of the eight types and subtypes of prostanoid receptors and examined the roles of prostanoids in dextran sodium sulfate–induced (DSS-induced) colitis. Among the prostanoid receptor–deficient mice, only EP4-deficient mice and not mice deficient in either DP, EP1, EP2, EP3, FP, IP, or TP developed severe colitis with 3% DSS treatment, which induced only marginal colitis in wild-type mice. This phenotype was mimicked in wild-type mice by administration of an EP4-selective ...
Tópico(s): NF-κB Signaling Pathways
2002 - American Society for Clinical Investigation | Journal of Clinical Investigation
Kenji Kabashima, Tomomi Saji, Tatsunori Murata, Miyako Nagamachi, Toshiyuki Matsuoka, Eri Segi‐Nishida, Kazuhito Tsuboi, Yukihiko Sugimoto, Takuya Kobayashi, Yoshiki Miyachi, Atsushi Ichikawa, Shuh Narumiya,
We used mice deficient in each of the eight types and subtypes of prostanoid receptors and examined the roles of prostanoids in dextran sodium sulfate–induced (DSS-induced) colitis. Among the prostanoid receptor–deficient mice, only EP4-deficient mice and not mice deficient in either DP, EP1, EP2, EP3, FP, IP, or TP developed severe colitis with 3% DSS treatment, which induced only marginal colitis in wild-type mice. This phenotype was mimicked in wild-type mice by administration of an EP4-selective ...
Tópico(s): NF-κB Signaling Pathways
2002 - American Society for Clinical Investigation | Journal of Clinical Investigation
Akihiko Ito, Tatsuya Kanto, Noriyoshi Kuzushita, Tomohide Tatsumi, Yoshiko Sugimoto, Takuya Miyagi, Tetsuo Takehara, Kazuhiro Katayama, Kiyoshi Mochizuki, Naoki Hiramatsu, Akinori Kasahara, Ikuto Yoshiya, Yutaka Sasaki, Masatsugu Hori, Norio Hayashi,
In hepatitis C virus (HCV) infection, cytotoxic T lymphocytes (CTL) are involved in liver inflammation and contribute to the reduction of viral load. Antibodies for HCV-CTL precursor frequencies (CTLpf) are relatively low in chronic hepatitis C, and this may be related to the poor CTL response in vivo. The aim of this study was to assess the efficacy of dendritic cells (DC) as antigen-presenting cells in CTL generation from low CTLpf.To confirm the rationale of using DC to prime naive T cells, five ...
Tópico(s): T-cell and B-cell Immunology
2001 - Wiley | Journal of Gastroenterology and Hepatology
Toshiyuki Matsuoka, Masakazu Hirata, Hiroyuki Tanaka, Yoshimasa Takahashi, Tatsunori Murata, Kenji Kabashima, Yukihiko Sugimoto, Takuya Kobayashi, Fumitaka Ushikubi, Yoshiya Aze, Naomi Eguchi, Yoshihiro Urade, Nobuaki Yoshida, Kazushi Kimura, Akira Mizoguchi, Yoshihito Honda, Hiroichi Nagai, Shuh Narumiya,
Allergic asthma is caused by the aberrant expansion in the lung of T helper cells that produce type 2 (T H 2) cytokines and is characterized by infiltration of eosinophils and bronchial hyperreactivity. This disease is often triggered by mast cells activated by immunoglobulin E (IgE)–mediated allergic challenge. Activated mast cells release various chemical mediators, including prostaglandin D 2 (PGD 2 ), whose role in allergic asthma has now been investigated by the generation of mice deficient in the ...
Tópico(s): Mast cells and histamine
2000 - American Association for the Advancement of Science | Science
Masaaki Sugimoto, Takuya Okagaki, Shinji Narisawa, YOSHIYUKI KOIDA, Kingo NAKAJIMA,
A novel cogrinding method for improving dissolution characteristics of poorly water-soluble drugs was developed. A coground mixture of nifedipine (NP)-polyethylene glycol 6000-hydroxypropylmethyl cellulose system prepared in the presence of small amount of water showed remarkable effect with respect to NP dissolution and its apparent solubility. Although the performance of the coground mixture was superior to that of spray-dried powder with the same composition, the X-ray diffraction pattern indicated ...
Tópico(s): Advanced Drug Delivery Systems
1998 - Elsevier BV | International Journal of Pharmaceutics
Takuya Sugimoto, Shigeki Wakizono, Takuya Uemura, Masazumi Tsuneyoshi, Munetomo Enjoji,
Abstract A rare case of a 71 -year-old man with malignant oncocytoma is presented. The tumour was found in the left parotid region with enlarged lymph nodes in the neck. The resected parotid mass consisted of three discrete nodules, each histologically characterized by a uniform proliferation of oncocytic tumour cells. The patient underwent repeated operations for recurrences and metastases, and eventually died of acute pneumonia 18 months after the first admission. Metastases to the lymph nodes, ...
Tópico(s): Tumors and Oncological Cases
1993 - Cambridge University Press | The Journal of Laryngology & Otology
Hiroshi Watanabe, Hiroshi Yamauchi, Masayoshi Ohashi, M. Sugimoto, Takuya Okada, Masahiro Fukase,
Tópico(s): Inorganic Fluorides and Related Compounds
1967 - Physical Society of Japan | Journal of the Physical Society of Japan
Mel F. Hainey, Takaaki Mano, Takeshi Kasaya, Tetsuyuki Ochiai, Hirotaka Osato, K. Watanabe, Yoshimasa Sugimoto, Takuya Kawazu, Yukinaga Arai, Akitsu Shigetou, Hideki T. Miyazaki,
Abstract The integration of quantum well infrared photodetectors with plasmonic cavities has allowed for demonstration of sensitive photodetectors in the mid-infrared up to room-temperature operating conditions. However, clear guidelines for optimizing device structure for these detectors have not been developed. Using simple stripe cavity detectors as a model system, we clarify the fundamental factors that improve photodetector performance. By etching semiconductor material between the stripes, ...
Tópico(s): Semiconductor Quantum Structures and Devices
2020 - De Gruyter | Nanophotonics
Masayo Sugimoto, Takuya Takeichi, Hideki Muramatsu, Daiei Kojima, Yukari Osada, Michihiro Kono, Seiji Kojima, Masashi Akiyama,
Tópico(s): Helicobacter pylori-related gastroenterology studies
2016 - Soc for Publication of Acta Dermato-Venereologica | Acta Dermato Venereologica
Takafumi Sugimoto, Takuya Yamada, Hisashi Iwata, T. Sekino, Shin Matsumoto, Naoto Ishida, Haruhiko Manabe, Mitsumasa Kimura, Hirofumi Takemura,
Recent reports have demonstrated that some patients are unable to undergo scheduled liver resection after preoperative portal vein embolization due to insufficient hypertrophy of the future remnant liver. The present study examined whether two-stage portal vein ligation (PVL) increases hypertrophy of the future remnant liver compared to conventional PVL in rats.Rats were divided into 3 groups: group A, ligation of left primary branch; group B, ligation of right and left primary branches; group C, ...
Tópico(s): Liver Disease Diagnosis and Treatment
2009 - Karger Publishers | European Surgical Research
Mel F. Hainey, Takaaki Mano, Takeshi Kasaya, Yoji Jimba, Hiroshi Miyazaki, Tetsuyuki Ochiai, Hirotaka Osato, Kazuhiro Watanabe, Yoshimasa Sugimoto, Takuya Kawazu, Yukinaga Arai, Akitsu Shigetou, Hideki T. Miyazaki,
Complex lightwave manipulation such as broadband absorption has been realized with metasurfaces based on laterally arranged metal-dielectric-metal cavities with different geometries. However, application of these metasurfaces for optoelectronic devices by incorporating functional dielectrics remains challenging. Here, we integrate a quantum well infrared photodetector (QWIP) with a metasurface made of a patchwork of square cavities with different dimensions arranged in a subwavelength unit cell. ...
Tópico(s): Advanced Antenna and Metasurface Technologies
2020 - Optica Publishing Group | Optics Express
Masaaki Motoori, Keijiro Sugimura, Koji Tanaka, Osamu Shiraishi, Yutaka Kimura, Hiroshi Miyata, Makoto Yamasaki, Tomoki Makino, Yasuhiro Miyazaki, Mitsuru Iwama, Kotaro Yamashita, Mai Niikura, Takuya Sugimoto, Takashi Asahara, Kazumasa Fujitani, Takushi Yasuda, Yuichiro� Doki, Masahiko Yano,
Established supportive care to reduce the toxicity of neoadjuvant chemotherapy (NAC) is lacking. This multicenter randomized study compared the administration of synbiotics combined with enteral nutrition (EN) versus that of prophylactic antibiotics as supportive care treatment for patients with esophageal cancer undergoing NAC.Patients with advanced esophageal cancer scheduled to receive NAC were randomly administered either prophylactic antibiotics (antibiotic group) or synbiotics combined with EN ( ...
Tópico(s): Neutropenia and Cancer Infections
2022 - Elsevier BV | Clinical Nutrition