Tomofumi Akasaka, Masahiko Tsujii, Jumpei Kondo, Yoshito Hayashi, Jin Ying, Yuquan Lu, Motohiko Kato, Takuya Yamada, Shunsuke Yamamoto, Takuya Inoue, Yoshiki Tsujii, Akira Maekawa, Tetsuji Fujinaga, Eri Shiraishi, Satoshi Hiyama, Takahiro Inoue, Shinichiro Shinzaki, Kenji Watabe, Tsutomu Nishida, Hideki Iijima, Tetsuo Takehara,
The emergence of chemoresistance is a major limitation of current cancer therapies, and checkpoint kinase (Chk1) 1 positively correlates with resistance to chemo‑ or radio‑therapy. Cancer cells lacking p53 pathways are completely dependent on the S and G2/M checkpoints via Chk1; therefore, Chk1 inhibition enhances the cytotoxicity of DNA‑damaging agents only in p53‑deficient cells. However, little is known about the synergistic effect of Chk1 inhibition with 5‑FU, the most frequently used antimetabolite, ...
Tópico(s): Cancer therapeutics and mechanisms
2014 - Spandidos Publishing | International Journal of Oncology
Motohiro Hirao, Takuya Yamada, Tomoki Michida, Kazuhiro Nishikawa, Takuya Hamakawa, Eiji Mita, Masayuki Mano, Mitsugu Sekimoto,
Since the risk of cancer cells seeding the peritoneum after perforation during endoscopic submucosal dissection (ESD) is unclear, we retrospectively examined peritoneal relapse after gastric perforation during ESD for gastric cancer at a single institution.Of 876 patients who underwent ESD for early gastric cancer between January 2002 and December 2015, 22 patients (2.5%) experienced gastric perforation during ESD at the Osaka National Hospital in Osaka, Japan. Clinical data from these 22 patients ...
Tópico(s): Gastrointestinal Tumor Research and Treatment
2017 - Karger Publishers | Digestive Surgery
Yoshiki Tsujii, Yoshito Hayashi, Naoki Kawai, Takuya Yamada, Katsumi Yamamoto, Shiro Hayashi, Shunsuke Yoshii, Kengo Nagai, Takuya Inoue, Tsutomu Nishida, Hideki Iijima, Eiji Mita, Atsuo Inoue, Tetsuo Takehara,
Endoscopic local steroid injection (LSI) has been used to prevent esophageal strictures after endoscopic submucosal dissection (ESD) for superficial esophageal neoplasms (SENs). This study aimed to evaluate the safety and efficacy of LSI therapy. From May 2007 to September 2014, at four institutions, 40 consecutive patients with SENs were treated with ESD that left a mucosal defect of more than three-quarters of the esophageal circumference. Two patients who underwent esophagectomy after ESD were excluded, ...
Tópico(s): Gastric Cancer Management and Outcomes
2017 - Thieme Medical Publishers (Germany) | Endoscopy International Open
Nobuyuki Takasu, Y. Handa, Y. Shimizu, Takuya Yamada,
In cultured porcine and human thyroid cells, electrophysiological and morphological studies showed that cultivation in the presence of TSH, prostaglandin E2 (PGE2) or dibutyryl cyclic AMP (dbcAMP) maintained normal cell polarity with iodine incorporation and organification. Cells cultivated in the absence of these substances had inverted cell polarity and lacked iodide incorporation. In the presence of TSH, PGE2 or dbcAMP, the thyroid cells formed follicles with normal cell polarity and the microvilli ...
Tópico(s): Ion channel regulation and function
1984 - Bioscientifica | Journal of Endocrinology
H. ARAI, Takuya Yamada, Koichi Eguchi, Tetsuro Seiyama,
Catalytic oxidation of methane was carried out over various perovskite-type oxides and compared with Pt/alumina catalyst. Of the oxides examined, partially cation-substituted LaFe, LaMn, and La-Co oxide systems showed high oxidation activities. Most excellent activity was attained by Sr-doped LaMnO3 (La0.6Sr0.4MnO3), which is almost as active as Pt/alumina catalyst at a conversion level below 80%. However, the increase in activity with temperature was significantly suppressed at a high conversion ...
Tópico(s): Catalysts for Methane Reforming
1986 - Elsevier BV | Applied Catalysis
Doreen Brandt, Yukio Muramatsu, K Ushio, Yasuhiro Mizuguchi, Michio Itabashi, Shouji Yoshida, Nobuyuki Moriyama, Shigeru Nawano, Tetuo Ishikawa, Takuya Yamada,
Synchronous early gastric cancer (EGC) has a prevalence of approximately 9%. The barium study findings of 73 patients with 163 synchronous EGC tumors were retrospectively reviewed, and the size, location, and morphologic type of each lesion considered malignant were analyzed and correlated with the endoscopic and final pathologic findings. Barium studies and endoscopy each correctly demonstrated 116 of the 163 synchronous EGC lesions. Those lesions not demonstrated by either technique were small, ...
Tópico(s): Gastrointestinal Tumor Research and Treatment
1989 - Radiological Society of North America | Radiology
Kiyokazu Nakajima, Toshirou Nishida, Tsuyoshi Takahashi, Yoshihito Souma, Johji Hara, Takuya Yamada, Toshiyuki Yoshio, Tateki Tsutsui, Takeshi Yokoi, Masaki Mori, Yuichiro� Doki,
Tópico(s): Gastric Cancer Management and Outcomes
2009 - Springer Science+Business Media | Surgical Endoscopy
Tsukasa Sakurada, Takuya Yamada, Koichi Tan‐No, Yoichi Manome, Shinobu Sakurada, Kensuke Kisara, Masataka Ohba,
Effects of five substance P (SP) analogs on the licking, biting and scratching response induced by neurokinin (NK) 1 receptor agonists such as SP, physalaemin and (p-Glu6,Pro9)-SP (6-11) (septide) were studied after intrathecal injections in mice. Septide brought about a SP-like behavioral response, and was approximately 25 times more potent than the D-Pro9 analog, D-septide. When administered simultaneously with NK-1 receptor agonists, a putative SP antagonist, spantide inhibited SP-, physalaemin- and ...
Tópico(s): Pain Mechanisms and Treatments
1991 - American Society for Pharmacology and Experimental Therapeutics | Journal of Pharmacology and Experimental Therapeutics
Ryu Ishihara, Takuya Yamada, Hiroyasu Iishi, Motohiko Kato, Shunsuke Yamamoto, Sachiko Yamamoto, Eriko Masuda, Koichi Tatsumi, Yoji Takeuchi, Koji Higashino, Noriya Uedo, Masaharu Tatsuta, Shingo Ishiguro,
Despite its high sensitivity for detecting esophageal cancer, chromoendoscopy with iodine staining has low specificity and requires many biopsy specimens, which is undesirable. Dramatic color change after iodine staining (initially whitish yellow and then pink 2 to 3 minutes later) has come to be recognized as the pink-color sign in cancerous lesions.The aim of the present study was to verify the accuracy of the pink-color sign for diagnosing esophageal squamous neoplasms by a quantitative analysis. ...
Tópico(s): Lung Cancer Diagnosis and Treatment
2008 - Elsevier BV | Gastrointestinal Endoscopy
Takuya Yamada, Hugh T. McElderry, Harish Doppalapudi, Michael Platonov, Andrew E. Epstein, Vance J. Plumb, G. Neal Kay,
A 49-year-old woman with dextrocardia and situs inversus underwent catheter ablation of paroxysmal atrial fibrillation. A contrast injection into the left atrium revealed that the left atrial appendage (LAA) was adjacent to the right-sided (anatomic left) superior pulmonary vein (PV). After successful isolation of that PV, LAA potentials were recorded from several electrode pairs of a circular PV mapping catheter. LAA may cause similar difficulties during PVI of the right-sided superior PV in a dextrocardia ...
Tópico(s): Congenital Heart Disease Studies
2008 - Oxford University Press | EP Europace
Ryu Ishihara, Hiroyasu Iishi, Noriya Uedo, Yoji Takeuchi, Sachiko Yamamoto, Takuya Yamada, Eriko Masuda, Koji Higashino, Motohiko Kato, Hiroyuki Narahara, Masaharu Tatsuta,
Background EMR and endoscopic submucosal dissection (ESD) are now being increasingly used for the treatment of esophageal cancers. However, their efficacies in smaller lesions have not been compared. Objective For effective use of these methods, we compared the results of ESD and 2 major EMR methods for treating esophageal cancers of ≤20 mm. Design A retrospective study. Setting A cancer-referral center. Patients A total of 136 patients with 171 lesions ≤20 mm who presented between January 2002 and ...
Tópico(s): Metastasis and carcinoma case studies
2008 - Elsevier BV | Gastrointestinal Endoscopy
Takuya Yamada, Hugh T. McElderry, Harish Doppalapudi, G. Neal Kay,
A 74-year-old man with idiopathic ventricular tachycardia (VT) with a QRS morphology with a left bundle branch block and right inferior axis underwent electrophysiologic testing. Successful ablation was achieved at the right coronary cusp (RCC) where an excellent pace map with long stimulus-to-QRS interval (St-QRS) (85 ms) was obtained. An excellent pace map was also obtained on the epicardial surface ∼1 cm away from the successful ablation site and the St-QRS was shorter (40 ms). These findings suggested ...
Tópico(s): Atrial Fibrillation Management and Outcomes
2008 - Oxford University Press | EP Europace
Kiyokazu Nakajima, Tsuyoshi Takahashi, Yoshihito Souma, Shinichiro Shinzaki, Takuya Yamada, Toshiyuki Yoshio, Toshirou Nishida,
Tópico(s): Esophageal and GI Pathology
2008 - Springer Science+Business Media | Surgical Endoscopy
Tomofumi Akasaka, Tsutomu Nishida, Shusaku Tsutsui, Tomoki Michida, Takuya Yamada, Hideharu Ogiyama, Shinji Kitamura, Makoto Ichiba, Masato Komori, Osamu Nishiyama, Fumihiko Nakanishi, Shinichiro Zushi, Akihiro Nishihara, Hideki Iijima, Masahiko Tsujii, Norio Hayashi,
Background: Endoscopic submucosal dissection (ESD) was developed for en bloc removal of large and flat gastrointestinal tract neoplasms. In Japan, ESD is performed under conscious sedation. The risks for sedation‐related complications of ESD, such as postoperative pneumonia, have not been evaluated. The aim of this study was to evaluate the incidence of postoperative pneumonia after ESD in a multicenter survey. Patients and Methods: A total of 1188 patients with upper gastric neoplasms treated with ...
Tópico(s): Helicobacter pylori-related gastroenterology studies
2010 - Wiley | Digestive Endoscopy
Hideharu Ogiyama, Yoshihiro Kamada, Shinichi Kiso, Hiroshi Araki, Takuya Yamada, Tamao Nishihara, Kenji Watabe, Yoshihiro Tochino, Shinji Kihara, Tohru Funahashi, Keishi Kanno, Iichiro Shimomura, Shusaku Tsutsui, Susumu Tazuma, Norio Hayashi,
Plasma adiponectin levels are reduced in obese people, and hypoadiponectinemia is recently reported to associate with cholesterol gallstone formation in human. The aim of this study was to examine the role of adiponectin in gallstone formation using adiponectin knockout mice. We analyzed male knockout and C57BL6J mice fed normal or lithogenic diet for 6 weeks. On lithogenic diet, the prevalence rate of gallstone was significantly greater in knockout mice than C57BL6J mice. The molar percentages ...
Tópico(s): Drug Transport and Resistance Mechanisms
2010 - Elsevier BV | Biochemical and Biophysical Research Communications
Shin‐ichiro Fujita, Takuya Yamada, Yoshinari Akiyama, Haiyang Cheng, Fengyu Zhao, Masahiko Arai,
Hydrogenation of phenol to cyclohexanone and cyclohexanol in/under compressed CO2 was examined using commercial Rh/C and Rh/Al2O3 catalysts to investigate the effects of CO2 pressurization on the total conversion and the product selectivity. Although the total rate of phenol hydrogenation with Rh/C was lowered by the presence of CO2, the selectivity to cyclohexanone was improved at high conversion levels >70%. On the other hand, the activity of Rh/Al2O3 was completely lost in an early stage of reaction. ...
Tópico(s): Catalytic Processes in Materials Science
2010 - Elsevier BV | The Journal of Supercritical Fluids
Motohiko Kato, Tsutomu Nishida, Shusaku Tsutsui, Masato Komori, Tomoki Michida, Katsumi Yamamoto, Naoki Kawai, Shinji Kitamura, Shinichiro Zushi, Akihiro Nishihara, Fumihiko Nakanishi, Kazuo Kinoshita, Takuya Yamada, Hideki Iijima, Masahiko Tsujii, Norio Hayashi,
Tópico(s): Gastrointestinal Tumor Research and Treatment
2010 - Springer Science+Business Media | Journal of Gastroenterology
Takuya Yamada, Vance J. Plumb, Hugh T. McElderry, Harish Doppalapudi, Andrew E. Epstein, G. Neal Kay,
AimsWe report the features of focal ventricular arrhythmias (VAs) arising from the left ventricle (LV) adjacent to the membranous septum.
Tópico(s): Atrial Fibrillation Management and Outcomes
2010 - Oxford University Press | EP Europace
Takuya Yamada, Hiroshi Araki, Kenji Watabe, Yoshihiro Kamada, Shinichi Kiso, Hideharu Ogiyama, Tamao Nishihara, Shinji Kihara, Tohru Funahashi, Iichiro Shimomura, Shusaku Tsutsui, Norio Hayashi,
Tópico(s): Apelin-related biomedical research
2010 - Springer Science+Business Media | Journal of Gastroenterology
Yoshitake Masuda, Takuya Yamada, Kunihito Koumoto,
We developed acicular BaTiO3 particles achieved by controlling the morphology of BaC2O4·0.5H2O to acicular shape and its phase transition to BaTiO3 by introducing Ti ions from the coprecipitated amorphous phase. Acicular BaTiO3 particles have an aspect ratio as high as 18, and the particle size can be controlled by varying the growth period of BaC2O4·0.5H2O, which governs the size of BaC2O4·0.5H2O particles. Acicular particles of crystalline BaTiO3 can be used for ultrathin multilayer ceramic capacitors.
Tópico(s): Dielectric materials and actuators
2007 - American Chemical Society | Crystal Growth & Design
Noriya Uedo, Yoji Takeuchi, Takuya Yamada, Ryu Ishihara, Hideharu Ogiyama, Sachiko Yamamoto, Hiroyasu Iishi, Masaharu Tatsuta,
Adjusted for Helicobacter pylori status, age, sex, smoking, NSAIDs use past 7 days, history of peptic ulcer, endoscopist, location of main tumor, and number of tumors.
Tópico(s): Gastrointestinal Tumor Research and Treatment
2007 - Elsevier BV | Gastrointestinal Endoscopy
Naomasa Yoshida, Hisashi Iwata, Takuya Yamada, T. Sekino, Hiroshi Matsuo, Koyo Shirahashi, Toshiyuki MIYAHARA, Shigeru Kiyama, Hirofumi Takemura,
Acute liver failure after massive hepatectomy is caused by both necrosis and apoptosis in the remnant liver. We investigate the protective effect of the caspase inhibitor on apoptosis after massive hepatectomy in rats.Benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone (ZVAD-fmk) is a general inhibitor of the caspase. Male Wister rats weighing 200-300 g were divided into three groups: 90Hx group undergoing 90% hepatectomy, 95Hx group undergoing 95% hepatectomy, 95Hx + ZVAD group undergoing 95% hepatectomy ...
Tópico(s): Organ Transplantation Techniques and Outcomes
2007 - Wiley | Journal of Gastroenterology and Hepatology
Yoji Takeuchi, Noriya Uedo, Hiroyasu Iishi, Sachiko Yamamoto, Shunsuke Yamamoto, Takuya Yamada, Koji Higashino, Ryu Ishihara, Masaharu Tatsuta, Shingo Ishiguro,
According to clinicopathologic studies, differentiated-type mucosal early gastric cancers without ulcer or ulcer scar have little risk of lymph-node metastasis, irrespective of tumor size. However, patients with large mucosal early gastric cancer have been subjected to surgery because conventional EMR methods could not resect large tumors en bloc.To evaluate the feasibility and the efficacy of endoscopic submucosal dissection for treatment of early gastric cancers larger than 3 cm in diameter.Case ...
Tópico(s): Gastrointestinal Tumor Research and Treatment
2007 - Elsevier BV | Gastrointestinal Endoscopy
Noriya Uedo, Yoji Takeuchi, Takuya Yamada, Ryu Ishihara, Hideharu Ogiyama, Sachiko Yamamoto, Motohiko Kato, Koichi Tatsumi, Eriko Masuda, Chie Tamai, Shunsuke Yamamoto, Koji Higashino, Hiroyasu Iishi, Masaharu Tatsuta,
With conventional methods of endoscopic mucosal resection for early gastric cancer (EGC), proton pump inhibitors (PPIs) and H2-receptor antagonists (H2RAs) have a similar effect on preventing bleeding from artificial ulcers. An objective of this study is to investigate whether a stronger acid suppressant (i.e., PPI) more effectively prevents bleeding after the recent advanced technique of endoscopic submucosal dissection (ESD) for EGC.This was a prospective randomized controlled trial performed in a ...
Tópico(s): Metastasis and carcinoma case studies
2007 - Lippincott Williams & Wilkins | The American Journal of Gastroenterology
Motohiko Kato, Kiyokazu Nakajima, Toshirou Nishida, Makoto Yamasaki, Tsutomu Nishida, Shusaku Tsutsui, Hideharu Ogiyama, Shunsuke Yamamoto, Takuya Yamada, Masaki Mori, Yuichiro� Doki, Norio Hayashi,
Combined laparoendoscopic surgery is a novel surgical method which consists of both endoscopic surgery from inside the gastrointestinal tract and laparoscopic surgery from the outside. We report a case of duodenal GIST, in which combined laparoendoscopic local resection was attempted. The lesion was resected endoscopically using endoscopic submucosal dissection technique under laparoscopic assistance. Laparoscope was used for originating the orientation of the tumor, intra-operative EUS, and monitoring ...
Tópico(s): Gastric Cancer Management and Outcomes
2011 - Hindawi Publishing Corporation | Diagnostic and therapeutic endoscopy
Noriya Uedo, Hiroyasu Iishi, Masaharu Tatsuta, Ryu Ishihara, Koji Higashino, Yoji Takeuchi, Kazuho Imanaka, Takuya Yamada, Sachiko Yamamoto, Shunsuke Yamamoto, Hideaki Tsukuma, Shingo Ishiguro,
Despite the widespread use of endoscopic mucosal resection (EMR) in patients with early gastric cancer (EGC), its longterm outcomes have not been fully evaluated. Our aim was to evaluate longterm survival after complete EMR for EGC. From patients who underwent EMR between 1978 and 1996 at our center, we enrolled 131 patients with differentiated mucosal EGCs less than 2 cm (without ulcerative change) that had been completely removed by EMR. The vital status of the patients at the end of December 1998 ...
Tópico(s): Helicobacter pylori-related gastroenterology studies
2006 - Springer Science+Business Media | Gastric Cancer
Kiyokazu Nakajima, Jong Ho Moon, Shusaku Tsutsui, Yasuaki Miyazaki, Makoto Yamasaki, Takuya Yamada, Motohiko Kato, Kazuhiro Yasuda, Kazuki Sumiyama, Naohisa Yahagi, Yoshihisa Saida, Hitoshi Kondo, Toshirou Nishida, Masaki Mori, Yuichiro� Doki,
Background and study aims: A new overtube system has been developed for steady pressure automatically controlled endoscopy (SPACE) in the gastrointestinal tract. The objectives of this study were to validate the feasibility and safety of SPACE in the esophagus, and to evaluate its potential advantages over conventional (manually insufflating) endoscopy in endoscopic submucosal dissection (ESD). Methods: This was a multicenter preclinical trial using acute porcine models (n = 20). In Experiment 1 (feasibility/safety ...
Tópico(s): Esophageal and GI Pathology
2012 - Thieme Medical Publishers (Germany) | Endoscopy
Shunsuke Yamamoto, Tsutomu Nishida, Motohiko Kato, Takuya Inoue, Yoshito Hayashi, Jumpei Kondo, Tomofumi Akasaka, Takuya Yamada, Shinichiro Shinzaki, Hideki Iijima, Masahiko Tsujii, Tetsuo Takehara,
We evaluated whether endoscopic ultrasonography (EUS) image quality affects the accuracy of diagnosing the vertical invasion depth of early gastric cancer (EGC). A total of 75 lesions in 75 patients suspected of having EGC were enrolled. All patients underwent EUS examination. Findings of EUS were compared with histopathologic results. We evaluated the effect of the following clinicopathologic factors: location, diameter, surface pattern, concomitant ulceration, histology type, and EUS image quality ...
Tópico(s): Esophageal and GI Pathology
2012 - Hindawi Publishing Corporation | Gastroenterology Research and Practice
Satoshi Nagao, Hisao Osuka, Takuya Yamada, Takeshi Uni, Yasuhito Shomura, Kiyohiro Imai, Yoshiki Higuchi, Shun Hirota,
Myoglobin (Mb) stores dioxygen in muscles, and is a fundamental model protein widely used in molecular design. The presence of dimeric Mb has been known for more than forty years, but its structural and oxygen binding properties remain unknown. From an X-ray crystallographic analysis at 1.05 Å resolution, we found that dimeric metMb exhibits a domain-swapped structure with two extended α-helices. Each new long α-helix is formed by the E and F helices and the EF-loop of the original monomer, and as ...
Tópico(s): Protein Structure and Dynamics
2012 - Royal Society of Chemistry | Dalton Transactions
Motohiko Kato, Tsutomu Nishida, Katsumi Yamamoto, Shiro Hayashi, Shinji Kitamura, Takamasa Yabuta, Toshiyuki Yoshio, Takeshi Nakamura, Masato Komori, Naoki Kawai, Akihiro Nishihara, Fumihiko Nakanishi, Masanori Nakahara, Hideharu Ogiyama, Kazuo Kinoshita, Takuya Yamada, Hideki Iijima, Masahiko Tsujii, Tetsuo Takehara,
Background After endoscopic submucosal dissection (ESD) of early gastric cancer (EGC), patients are at high risk for synchronous or metachronous multiple gastric cancers. Objective To elucidate the time at which multiple cancers develop and to determine whether scheduled endoscopic surveillance might control their development. Design A multicentre retrospective cohort study from 12 hospitals was conducted. Patients with EGC who underwent ESD with en bloc margin-negative curative resection were included. Synchronous ...
Tópico(s): Helicobacter pylori-related gastroenterology studies
2012 - BMJ | Gut