Avital Kozlovsky, Haim Tal, Ben‐Zion Laufer, Roy Leshem, Michael D. Rohrer, Miron Weinreb, Zvi Artzi,
To assess the impact of overloading on peri-implant bone level and the bone-to-implant contact (BIC) in the presence of healthy or inflamed peri-implant tissues.Four screw-shaped machined implants were placed bilaterally in the mandible of four beagle dogs and left submerged for 3 months. Prosthetic abutments were connected either in supra-occlusal contact with the opposite teeth (overloaded) or in infra-occlusal position (unloaded). In each dog, cotton floss ligatures were placed unilaterally around ...
Tópico(s): Cleft Lip and Palate Research
2007 - Wiley | Clinical Oral Implants Research
Produção Nacional
Revisado por pares
Martin Maška, Vladimír Ulman, Pablo Delgado-Rodriguez, Estibaliz Gómez‐de‐Mariscal, Tereza Nečasová, Fidel A. Guerrero Peña, Tsang Ing Ren, Elliot M. Meyerowitz, Tim Scherr, Katharina Löffler, Ralf Mikut, Tianqi Guo, Yin Wang, Jan P. Allebach, Rina Bao, Noor Al-Shakarji, Gani Rahmon, Imad Eddine Toubal, Kannappan Palaniappan, Filip Lux, Petr Matula, Ko Sugawara, Klas E. G. Magnusson, Layton Aho, Andrew R. Cohen, Assaf Arbelle, Tal Ben-Haim, Tammy Riklin Raviv, Fabian Isensee, Paul F. Jäger, Klaus Maier‐Hein, Yanming Zhu, Cristina Ederra, Ainhoa Urbiola, Erik Meijering, Alexandre Cunha, Arrate Muñoz‐Barrutia, Michal Kozubek, Carlos Ortiz‐de‐Solórzano,
Abstract The Cell Tracking Challenge is an ongoing benchmarking initiative that has become a reference in cell segmentation and tracking algorithm development. Here, we present a significant number of improvements introduced in the challenge since our 2017 report. These include the creation of a new segmentation-only benchmark, the enrichment of the dataset repository with new datasets that increase its diversity and complexity, and the creation of a silver standard reference corpus based on the ...
Tópico(s): Advanced Fluorescence Microscopy Techniques
2023 - Nature Portfolio | Nature Methods
Tal Ben-Haim, Tammy Riklin Raviv,
We present a novel graph neural network (GNN) approach for cell tracking in high-throughput microscopy videos. By modeling the entire time-lapse sequence as a direct graph where cell instances are represented by its nodes and their associations by its edges, we extract the entire set of cell trajectories by looking for the maximal paths in the graph. This is accomplished by several key contributions incorporated into an end-to-end deep learning framework. We exploit a deep metric learning algorithm ...
Tópico(s): AI in cancer detection
2022 - Springer Science+Business Media | Lecture notes in computer science
Hadas Ner‐Gaon, Ariel Melchior, Nili Golan, Yael Ben-Haim, Tal Shay,
Abstract Recent advances in single-cell RNA–sequencing (scRNA-seq) technology increase the understanding of immune differentiation and activation processes, as well as the heterogeneity of immune cell types. Although the number of available immune-related scRNA-seq datasets increases rapidly, their large size and various formats render them hard for the wider immunology community to use, and read-level data are practically inaccessible to the non-computational immunologist. To facilitate datasets ...
Tópico(s): T-cell and B-cell Immunology
2017 - American Association of Immunologists | The Journal of Immunology
Shay Bar‐Haim, Ayelet Aharon, Tal Ben-Moshe, Yael Marantz, Hanoch Senderowitz,
Identifying active compounds (hits) that bind to biological targets of pharmaceutical relevance is the cornerstone of drug design efforts. Structure based virtual screening, namely, the in silico evaluation of binding energies and geometries between a protein and its putative ligands, has emerged over the past few years as a promising approach in this field. The success of the method relies on the availability of reliable 3-dimensional (3D) structures of the target protein and its candidate ligands ( ...
Tópico(s): Quantum Computing Algorithms and Architecture
2009 - American Chemical Society | Journal of Chemical Information and Modeling
Michael Bernhofer, Christian Dallago, Tim Karl, Venkata Satagopam, Michael Heinzinger, Maria Littmann, Tobias Olenyi, Jiajun Qiu, Konstantin Schütze, Guy Yachdav, Haim Ashkenazy, Nir Ben‐Tal, Yana Bromberg, Tatyana Goldberg, Laszló Kaján, Séan O’Donoghue, Chris Sander, Andrea Schafferhans, Avner Schlessinger, Gerrit Vriend, Milot Mirdita, Piotr Gawron, Wei Gu, Yohan Jarosz, Christophe Trefois, Martin Steinegger, Reinhard Schneider, Burkhard Rost,
Abstract Since 1992 PredictProtein (https://predictprotein.org) is a one-stop online resource for protein sequence analysis with its main site hosted at the Luxembourg Centre for Systems Biomedicine (LCSB) and queried monthly by over 3,000 users in 2020. PredictProtein was the first Internet server for protein predictions. It pioneered combining evolutionary information and machine learning. Given a protein sequence as input, the server outputs multiple sequence alignments, predictions of protein ...
Tópico(s): Advanced Proteomics Techniques and Applications
2021 - Oxford University Press | Nucleic Acids Research
Adi Ben Chorin, Gal Masrati, Amit Kessel, Aya Narunsky, Josef Sprinzak, Shlomtzion Lahav, Haim Ashkenazy, Nir Ben‐Tal,
Patterns observed by examining the evolutionary relationships among proteins of common origin can reveal the structural and functional importance of specific residue positions. In particular, amino acids that are highly conserved (i.e., their positions evolve at a slower rate than other positions) are particularly likely to be of biological importance, for example, for ligand binding. ConSurf is a bioinformatics tool for accurately estimating the evolutionary rate of each position in a protein family. ...
Tópico(s): Microbial Metabolic Engineering and Bioproduction
2019 - Wiley | Protein Science
Haim Weissman, Elijah Shirman, Tal Ben-Moshe, Revital Cohen, Gregory Leitus, Linda J. W. Shimon, Boris Rybtchinski,
We prepared the first sigma-bonded metal complexes of widely utilized organic dyes, perylene tetracarboxylic acid diimides (PDIs). These 1,7-dipalladium PDI complexes were synthesized by C-Br oxidative addition of 1,7-dibromo-N,N'-dicyclohexyl PDI (Br2PDI) to Pd(0) phosphine complexes bearing triphenylphosphine and bischelating 1,2-bis(diphenylphosphino)ethane (dppe). The structures of Pd-PDI complexes were elucidated by single-crystal X-ray analysis. Surprisingly, despite direct attachement of two ...
Tópico(s): Luminescence and Fluorescent Materials
2007 - American Chemical Society | Inorganic Chemistry
Emir Haleva, Nir Ben‐Tal, Haim Diamant,
We studied the adsorption of a charged protein onto an oppositely charged membrane, composed of mobile phospholipids of differing valence, using a statistical-thermodynamical approach. A two-block model was employed, one block corresponding to the protein-affected region on the membrane, referred to as the adsorption domain, and the other to the unaffected remainder of the membrane. We calculated the protein-induced lipid rearrangement in the adsorption domain as arising from the interplay between ...
Tópico(s): Molecular Junctions and Nanostructures
2004 - Elsevier BV | Biophysical Journal
Mukesh Sharma, Lior Michaeli, Danielle Ben Haim, Tal Ellenbogen,
Surface lattice resonances (SLRs) on metasurfaces strongly enhance the interaction of light with the metasurface and can be used for obtaining very high-Q response, high spectral sensitivity, and strong optical nonlinearities. Here, we study experimentally and numerically the dynamic switching of SLRs in gold nanoantenna metasurfaces fabricated on top of indium tin oxide by use of electrically controlled liquid crystals. Experimental results show that the cumulative effects of the anisotropic optical ...
Tópico(s): Orbital Angular Momentum in Optics
2022 - American Chemical Society | ACS Photonics
Hila Ene, Nirit Kara, Noa Barak, Tal Reshef Ben-Mordechai, Haim Einat,
A number of atypical antipsychotic drugs were demonstrated to have anxiolytic effects in patients and in animal models. These effects were mostly suggested to be the consequence of the drugs' affinity to the serotonin system and its receptors. Asenapine is a relatively new atypical antipsychotic that is prescribed for schizophrenia and for bipolar mania. Asenapine has a broad pharmacological profile with significant effects on serotonergic receptors, hence it is reasonable to expect that asenapine ...
Tópico(s): Receptor Mechanisms and Signaling
2015 - Cambridge University Press | Acta Neuropsychiatrica
Itay Sisso, Tal Shima, Yakov Ben‐Haim,
A robust-satisficing approach based on info-gap theory is suggested as a solution for a spatial search-planning problem with imprecise probabilistic data. A group of agents are searching predefined patches of land for stationary targets, given an a priori probability map of the targets' locations. This prior probabilistic information is assumed to be severely uncertain and may contain large errors. An analysis of a simplified case shows that in some situations, one might prefer a different strategy ...
Tópico(s): Game Theory and Applications
2010 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Robotics
Gilad Wainreb, Lior Wolf, Haim Ashkenazy, Yves Dehouck, Nir Ben‐Tal,
Abstract Motivation: Accurate prediction of protein stability is important for understanding the molecular underpinnings of diseases and for the design of new proteins. We introduce a novel approach for the prediction of changes in protein stability that arise from a single-site amino acid substitution; the approach uses available data on mutations occurring in the same position and in other positions. Our algorithm, named Pro-Maya (Protein Mutant stAbilitY Analyzer), combines a collaborative filtering ...
Tópico(s): RNA and protein synthesis mechanisms
2011 - Oxford University Press | Bioinformatics
Haim Shmilovich, Jeremy Ben‐Shoshan, Reshef Tal, Arnon Afek, Iris Barshack, Sofia Maysel-Auslander, Dror Harats, Gad Keren, Jacob George,
Objective: To test the hypothesis that B-type natriuretic peptide (BNP) acts as a potent vasculogenic agent by enhancing the number, proliferation, adhesion, and migration of endothelial progenitor cells (EPCs). Background: BNP is a neurohormonal peptide that predicts outcome and used for treatment in chronic heart failure patients. It has been shown to promote angiogenesis in experimental animals. EPCs have been demonstrated to contribute to postnatal angiogenesis and vasculogenesis. Methods: The ...
Tópico(s): Cardiac and Coronary Surgery Techniques
2009 - Mary Ann Liebert, Inc. | Tissue Engineering Part A
Menahem Ben‐Haim, Joseph Kuriansky, R. Tal, Oded Zmora, Yoav Mintz, Danny Rosin, Amram Ayalon, Moshe Shabtai,
Tópico(s): Intestinal and Peritoneal Adhesions
2002 - Springer Science+Business Media | Surgical Endoscopy
Aya Narunsky, Sergey Nepomnyachiy, Haim Ashkenazy, Rachel Kolodny, Nir Ben‐Tal,
Protein function involves conformational changes, but often, for a given protein, only some of these conformations are known. The missing conformations could be predicted using the wealth of data in the PDB. Most PDB proteins have multiple structures, and proteins sharing one similar conformation often share others as well. The ConTemplate web server (http://bental.tau.ac.il/contemplate) exploits these observations to suggest conformations for a query protein with at least one known conformation ( ...
Tópico(s): Enzyme Structure and Function
2015 - Elsevier BV | Structure
Ilan Volovitz, Netanel Shapira, Haim Ezer, Aviv Gafni, Merav Lustgarten, Tal Alter, Idan Ben‐Horin, Ori Barzilai, Tal Shahar, Andrew A. Kanner, Itzhak Fried, Igor Veshchev, Rachel Grossman, Zvi Ram,
Conducting research on the molecular biology, immunology, and physiology of brain tumors (BTs) and primary brain tissues requires the use of viably dissociated single cells. Inadequate methods for tissue dissociation generate considerable loss in the quantity of single cells produced and in the produced cells' viability. Improper dissociation may also demote the quality of data attained in functional and molecular assays due to the presence of large quantities cellular debris containing immune-activatory ...
Tópico(s): RNA Interference and Gene Delivery
2016 - BioMed Central | BMC Neuroscience
Haim Ashkenazy, Elona Erez, Eric Martz, Tal Pupko, Nir Ben‐Tal,
It is informative to detect highly conserved positions in proteins and nucleic acid sequence/structure since they are often indicative of structural and/or functional importance. ConSurf (http://consurf.tau.ac.il) and ConSeq (http://conseq.tau.ac.il) are two well-established web servers for calculating the evolutionary conservation of amino acid positions in proteins using an empirical Bayesian inference, starting from protein structure and sequence, respectively. Here, we present the new version ...
Tópico(s): Genomics and Phylogenetic Studies
2010 - Oxford University Press | Nucleic Acids Research
Elinor Goshen, Leonid Beilin, Eli Stern, Tal Kenig, Ronen Goldkorn, Simona Ben‐Haim,
The performance of a prototype novel digital single-photon emission computed tomography (SPECT) camera with multiple pixelated CZT detectors and high sensitivity collimators (Digital SPECT; Valiance X12 prototype, Molecular Dynamics) was evaluated in various clinical settings. Images obtained in the prototype system were compared to images from an analog camera fitted with high-resolution collimators. Clinical feasibility, image quality, and diagnostic performance of the prototype were evaluated in ...
Tópico(s): Advanced X-ray and CT Imaging
2018 - Springer Science+Business Media | EJNMMI Physics
Tal Engel, Bella Ungar, Gal Ben-Haim, Nina Levhar, Rami Eliakim, Shomron Ben‐Horin,
Non-adherence to medication in patients with inflammatory bowel disease (IBD) is a challenging problem which is often overlooked or under-estimated by the physician or denied by the patient. We aimed to examine if re-phrasing the wording of the question used by the physician could help in revealing more patients who are non-adherent, and for whom appropriate counseling may be instituted.A cross-sectional questionnaire-based study of IBD patients treated in a tertiary center was conducted. Patients ...
Tópico(s): Bipolar Disorder and Treatment
2017 - Wiley | United European Gastroenterology Journal
Peleg Ben‐Galim, Tal Ben-Galim, Nahshon Rand, Amir Haim, John A. Hipp, Shmuel Dekel, Yizhar Floman,
Prospective clinical study on the effect of total hip replacement surgery (THR) on low back pain (LBP) in patients with severe hip osteoarthritis.To assess the affect of THR on LBP.Hip osteoarthritis causes abnormal gait and spinal sagittal alignment and is associated with LBP.All consecutive adults scheduled for THR in our department due to severe hip osteoarthritis were assessed by an independent investigator before surgery and 3 months and 2 years post-THR. The Harris Hip Score and the Oswestry ...
Tópico(s): Musculoskeletal pain and rehabilitation
2007 - Lippincott Williams & Wilkins | Spine
Gal Masrati, Manish Dwivedi, Abraham Rimon, Yael Gluck-Margolin, Amit Kessel, Haim Ashkenazy, Itay Mayrose, Etana Padan, Nir Ben‐Tal,
Cation/proton antiporters (CPAs) play a major role in maintaining living cells' homeostasis. CPAs are commonly divided into two main groups, CPA1 and CPA2, and are further characterized by two main phenotypes: ion selectivity and electrogenicity. However, tracing the evolutionary relationships of these transporters is challenging because of the high diversity within CPAs. Here, we conduct comprehensive evolutionary analysis of 6537 representative CPAs, describing the full complexity of their phylogeny, ...
Tópico(s): Protein Structure and Dynamics
2018 - Nature Portfolio | Nature Communications
JoséM. Grünzweig, Haim D. Rabinowitch, J. Katan, Maria Wodner, Y. Ben-Tal,
Endogenous gibberellins (GAs) from the leaves and shoot tips of 13–14 days old tomato transplants (Lycopersicon esculentum Mill.) grown in solarised or non-solarised soil were analysed by GC-mass spectrometry. Full-scan mass spectra and Kovats retention indices, revealed in plants from both soils the presence of GA1, GA3, GA3-isolactone, GA4, GA8,GA19, GA20, GA29, GA34 and GA51. Further analyses by GC-SIM indicated the presence of GA44 and GA53 in the tomato foliage. An isotope-dilution analysis revealed ...
Tópico(s): Plant Reproductive Biology
1997 - Elsevier BV | Phytochemistry
Gershon Celniker, Guy Nimrod, Haim Ashkenazy, Fabian Glaser, Eric Martz, Itay Mayrose, Tal Pupko, Nir Ben‐Tal,
Abstract Many mutations disappear from the population because they impair protein function and/or stability. Thus, amino acid positions that are essential for proper function evolve more slowly than others, or in other words, the slow evolutionary rate of a position reflects its importance. ConSurf ( http://consurf.tau.ac.il ), reviewed in this manuscript, exploits this to reveal key amino acid positions that are important for maintaining the native conformation(s) of the protein and its function, be ...
Tópico(s): Protein Structure and Dynamics
2013 - Wiley | Israel Journal of Chemistry
Kira Oleinikov, Inbal Uri, Harold Jacob, Julia Epshtein, Ariel A. Benson, Simona Ben‐Haim, Karine Atlan, Ilanit Tal, Amichay Meirovitz, Ofra Maimon, Naama Lev‐Cohain, Haggi Mazeh, Benjamin Gläser, David J. Gross, Simona Grozinsky‐Glasberg,
Tópico(s): Neuroblastoma Research and Treatments
2020 - Springer Science+Business Media | Endocrine
Danielle Ben Haim, Lior Michaeli, Ori Avayu, Tal Ellenbogen,
We study the optical response of plasmonic metasurface etalons in reflection. The etalons consist of a metallic mirror and a plasmonic metasurface separated by wavelength-scale dielectric spacer. We show that tuning the localized surface plasmon resonance and spacer thickness can be used to achieve both enhanced reflectivity and perfect absorption, in addition to full 2π range phase control, and tunable regions of normal and anomalous dispersion. We validate our claims by measuring the spectral ...
Tópico(s): Orbital Angular Momentum in Optics
2020 - Optica Publishing Group | Optics Express
Nimrod Dar, Liron Naftali Ben Haim, Veronika Yehezkeli, Tal Sharon, Avner Belkin,
Purpose: To evaluate the efficacy and safety of gonioscopy-assisted transluminal trabeculotomy (GATT) in patients with advanced glaucoma. Methods: Records of 46 patients with advanced glaucoma were reviewed retrospectively in this single-center chart review. The main outcome measure was surgical success; intra-ocular pressure (IOP) and IOP lowering medication use were secondary outcome measures. Success was defined as an IOP of 18 mmHg or lower (criterion A) or 14 mmHg or lower (criterion B) and one ...
Tópico(s): Retinal Diseases and Treatments
2023 - Medknow | Indian Journal of Ophthalmology
Haim Ashkenazy, Shiran Abadi, Eric Martz, Ofer Chay, Itay Mayrose, Tal Pupko, Nir Ben‐Tal,
The degree of evolutionary conservation of an amino acid in a protein or a nucleic acid in DNA/RNA reflects a balance between its natural tendency to mutate and the overall need to retain the structural integrity and function of the macromolecule. The ConSurf web server (http://consurf.tau.ac.il), established over 15 years ago, analyses the evolutionary pattern of the amino/nucleic acids of the macromolecule to reveal regions that are important for structure and/or function. Starting from a query ...
Tópico(s): Machine Learning in Bioinformatics
2016 - Oxford University Press | Nucleic Acids Research
Jacob Romano, Guy Nimrod, Nir Ben‐Tal, Yona Shadkchan, Koti Baruch, Haim Sharon, Nir Osherov,
The ECM33/SPS2 family of glycosylphosphatidylinositol-anchored proteins plays an important role in maintaining fungal cell wall integrity and virulence. However, the precise molecular role of these proteins is unknown. In this work, AfuEcm33, the gene encoding the ECM33 homologue in the important pathogenic fungus Aspergillus fumigatus, has been cloned and its function analysed. It is shown that disruption of AfuEcm33 results in rapid conidial germination, increased cell-cell adhesion, resistance ...
Tópico(s): Mycotoxins in Agriculture and Food
2006 - Microbiology Society | Microbiology
Mai Tal, Danielle Ben Haim, Tal Ellenbogen,
Tópico(s): Laser-Matter Interactions and Applications
2021 - Higher Education Press | Frontiers of Physics