Amanda Andrews, Andrew Billen, Martin Neary President, Sarah Potter, Canon James Lancelot Master, Frances Gibb Legal Editor, Mark Souster, David Rose, Robert Steel, Philip Howard, Carol Midgley, Hilary Finch, David Lister Scotland Correspondent, David Chater, James Bone, Mark Irving Art Critic, Penny Wark, Clive Davis, Lorna Blackwood, Alexandra Frean Social Affairs Correspondent, Chris Gravell Policy Officer, Richard Hobson One-Day Cricket Correspondent, Bob Stanley, Sam Marlowe, Geoff Brown, Andrew Norfolk, Ben Webster Transport Correspondent, Pat Gibson, Mark Simpson, Tom Bawden, Steve Bird, James Doran Wall Street Correspondent, Jill Dupleix, Rosemary Bennett, M. F. Horton, Angela Jameson Industrial Correspondent, Dalya Alberge Arts Correspondent, Phoebe Greenwood, Anne Ashworth Property Editor, Michael Evans and Joe Bolger, Alan Hamilton, David Sharrock Ireland Correspondent, Stephen Farrell, Jayne Dowle, Ron Lewis, Matt Dickinson Chief Football Correspondent, Erica Munro, Daniel McGrory, Jerome Burne, Gary Duncan Economics Editor, Oliver Kay, Christine Selb, Ed Potton, John Bedwell, Rick Broadbent, Tom Baldwin, Tim Kingswood, Jan Fry Director, Pete Paphides, Dr Hsu Phern Chong, John Hopkins Golf Correspondent, Rob Wright, Neil Harman Tennis Correspondent, Marcus Binney, Vaughan Freeman, Lucia Adams, Adam Sage, Matt Hughes, Peter Wright President, Chris Campling, Fran Yeoman, Trevor Harvey, Bronwen Maddox, Ron Cox, Richard Owen, Dr Sujeev Mathur, Damian Whitworth, Gabriel Rozenberg Economics Reporter, Nick Hasell, Malcolm Archer Director of Music, Paul Lynn, David Hands Rugby Correspondent, Julian Muscat, Paul Simons, Mary Ann Sieghart, Andrew Plerce, Queen Elizabeth Hall, Harmonia Mundi, Sarah Beeny, Thomas Trotter, Ian Johns, George Caulkin, Bruce Anderson, Russell Jenkins, Neil Fisher, Tim Martin, Peter Riddell, Ben MacIntyre, Lucia van der Post, Mark Henderson, Martin Waller, Patrick Foster, Nigel Hawkes Health Editor, Sarah Butler, Benedict Nightingale, Angus Batey, Richard Law, Stephen Dalton, Melody Amber, Richard Morrison, Angus MacLeod and Shirley English, Alan Lee Racing Correspondent, Peter Robinson, Peter Klinger, Nick Meo, Ben West, Elizabeth Judge Telecoms Correspondent, Susan Emmett,
... Harvard flocks to see the guru of happiness Tal Ben-Shahar's Happiness Tips Leak was authorised by Bush, ...
2006 - Gale Group | TDA
Amandine Lassalle, Delia Pigat, Helen O’Reilly, Steve Berggen, Shimrit Fridenson-Hayo, Shahar Tal, Sigrid Elfström, Anna Råde, Ofer Golan, Sven Bölte, Simon Baron‐Cohen, Daniel Lundqvist,
In this study, we report the validation results of the EU-Emotion Voice Database, an emotional voice database available for scientific use, containing a total of 2,159 validated emotional voice stimuli. The EU-Emotion voice stimuli consist of audio-recordings of 54 actors, each uttering sentences with the intention of conveying 20 different emotional states (plus neutral). The database is organized in three separate emotional voice stimulus sets in three different languages (British English, Swedish, ...
Tópico(s): Color perception and design
2018 - Springer Science+Business Media | Behavior Research Methods
Erik Marchi, Tadas Baltrušaitis, Andra Adams, Marwa Mahmoud, Ofer Golan, Shimrit Fridenson-Hayo, Shahar Tal, S. Newman, Noga Meir-Goren, Antonio Camurri, Stefano Piana, Björn W. Schuller, Sven Bölte, Tevfik Metin Sezgin, Neşe Alyüz, Agnieszka Rynkiewicz, Aurélie Baranger, Alice Baird, Simon Baron‐Cohen, Amandine Lassalle, Helen O’Reilly, Delia Pigat, Peter Robinson, Ian Davies,
"Serious games" are becoming extremely relevant to individuals who have specific needs, such as children with an autism spectrum condition (ASC). Often, individuals with an ASC have difficulties in interpreting verbal and nonverbal communication cues during social interactions. The ASC-Inclusion EU-FP7 funded project aims to provide children who have an ASC with a platform to learn emotion expression and recognition, through play in the virtual world. In particular, the ASC-Inclusion platform focuses ...
Tópico(s): Gaze Tracking and Assistive Technology
2018 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Games
Shimrit Fridenson-Hayo, Steve Berggren, Amandine Lassalle, Shahar Tal, Delia Pigat, Noga Meir-Goren, Helen O’Reilly, S. Ben-Zur, Sven Bölte, Simon Baron‐Cohen, Ofer Golan,
Tópico(s): Child and Animal Learning Development
2017 - Springer Science+Business Media | European Child & Adolescent Psychiatry
Shimrit Fridenson-Hayo, Steve Berggren, Amandine Lassalle, Shahar Tal, Delia Pigat, Sven Bölte, Simon Baron‐Cohen, Ofer Golan,
Children with autism spectrum conditions (ASC) have emotion recognition deficits when tested in different expression modalities (face, voice, body). However, these findings usually focus on basic emotions, using one or two expression modalities. In addition, cultural similarities and differences in emotion recognition patterns in children with ASC have not been explored before. The current study examined the similarities and differences in the recognition of basic and complex emotions by children ...
Tópico(s): Behavioral and Psychological Studies
2016 - BioMed Central | Molecular Autism
Helen O’Reilly, Delia Pigat, Shimrit Fridenson, Steve Berggren, Shahar Tal, Ofer Golan, Sven Bölte, Simon Baron‐Cohen, Daniel Lundqvist,
The EU-Emotion Stimulus Set is a newly developed collection of dynamic multimodal emotion and mental state representations. A total of 20 emotions and mental states are represented through facial expressions, vocal expressions, body gestures and contextual social scenes. This emotion set is portrayed by a multi-ethnic group of child and adult actors. Here we present the validation results, as well as participant ratings of the emotional valence, arousal and intensity of the visual stimuli from this ...
Tópico(s): Multisensory perception and integration
2015 - Springer Science+Business Media | Behavior Research Methods
Tuvia Peri, Mordechai Gofman, Shahar Tal, Rivka Tuval‐Mashiach,
Exposure to the trauma memory is the common denominator of most evidence-based interventions for posttraumatic stress disorder (PTSD). Although exposure-based therapies aim to change associative learning networks and negative cognitions related to the trauma memory, emotional interactions between patient and therapist have not been thoroughly considered in past evaluations of exposure-based therapy. This work focuses on recent discoveries of the mirror-neuron system and the theory of embodied simulation ( ...
Tópico(s): Empathy and Medical Education
2015 - Taylor & Francis | European journal of psychotraumatology
Shir Filo, Rona Shaharabani, Daniel Bar Hanin, Miriam Adam, Eliel Ben-David, Hanan Schoffman, Nevo Margalit, Naomi Habib, Tal Shahar, Aviv Mezer,
Strict iron regulation is essential for normal brain function. The iron homeostasis, determined by the milieu of available iron compounds, is impaired in aging, neurodegenerative diseases and cancer. However, non-invasive assessment of different molecular iron environments implicating brain tissue's iron homeostasis remains a challenge. We present a magnetic resonance imaging (MRI) technology sensitive to the iron homeostasis of the living brain (the r1-r2* relaxivity). In vitro, our MRI approach ...
Tópico(s): Iron Metabolism and Disorders
2023 - Nature Portfolio | Nature Communications
Nomi Zalcman, Tamar Canello, Haim Ovadia, Hanna Charbit, Bracha Zelikovitch, Anat Mordechai, Yakov Fellig, Stav Rabani, Tal Shahar, Alexander Lossos, Iris Lavon,
... 1, 3 , Yakov Fellig 4 , Stav Rabani 5 , Tal Shahar 5, 6 , Alexander Lossos 1, 2, 3, ** and ...
Tópico(s): Glioma Diagnosis and Treatment
2018 - Impact Journals LLC | Oncotarget
Ravit Edelman, Yehuda G. Assaraf, Inna Levitzky, Tal Shahar, Yoav D. Livney,
... 1 , Yehuda G. Assaraf 2 , Inna Levitzky 1 , Tal Shahar 1 , Yoav D. Livney 1, 3 1 Department ...
Tópico(s): RNA Interference and Gene Delivery
2017 - Impact Journals LLC | Oncotarget
Rachel Grossman, Erez Nossek, R. Sitt, Daniel Hayat, Tal Shahar, Ori Barzilai, Tal Gonen, Akiva Korn, Gal Sela, Zvi Ram,
Tópico(s): Traumatic Brain Injury and Neurovascular Disturbances
2012 - Springer Science+Business Media | Annals of Surgical Oncology
Joshua Milgram, Ron Shahar, Tal Levin‐Harrus, Philip H. Kass,
Abstract The object of this study was to examine the effect of high intensity, short duration pulsed electromagnetic fields (PEMF) on the healing of full thickness skin wounds in rats. Full thickness skin wounds were surgically created in two groups of Sprague–Dawley male rats. The rats were randomly divided into two groups, each containing 20 rats. Animals in the treatment group received treatments with the PEMF device on day 0, 3, 7, 9, 12, 14, 17, and 22, while the rats in the control group were ...
Tópico(s): Planarian Biology and Electrostimulation
2004 - Wiley | Bioelectromagnetics
... DREAM Project Revital Nimri, Eran Atlas, Michal Ajzensztejn, Shahar Miller, Tal Oron, and Moshe Phillip1 August 2012 | Diabetes Technology & ...
Tópico(s): Diabetes and associated disorders
2003 - Mary Ann Liebert, Inc. | Diabetes Technology & Therapeutics
Erez Nossek, Idit Matot, Tal Shahar, Ori Barzilai, Yoni Rapoport, Tal Gonen, Gal Sela, Rachel Grossman, Akiva Korn, Daniel Hayat, Zvi Ram,
Awake craniotomy (AC) for removal of intra-axial brain tumors is a well-established procedure. However, the occurrence and consequences of intraoperative seizures during AC have not been well characterized.To analyze the incidence, risk factors, and consequences of seizures during AC.The database of AC at Tel Aviv Medical Center between 2003 to 2011 was reviewed. Occurrences of intraoperative seizures were analyzed with respect to medical history, medications, tumor characteristics, and postoperative ...
Tópico(s): Traumatic Brain Injury and Neurovascular Disturbances
2013 - Lippincott Williams & Wilkins | Neurosurgery
Erez Nossek, Idit Matot, Tal Shahar, Ori Barzilai, Yoni Rapoport, Tal Gonen, Gal Sela, Akiva Korn, Daniel Hayat, Zvi Ram,
Awake craniotomy for removal of intraaxial tumors within or adjacent to eloquent brain regions is a well-established procedure. However, awake craniotomy failures have not been well characterized. In the present study, the authors aimed to analyze and assess the incidence and causes for failed awake craniotomy.The database of awake craniotomies performed at Tel Aviv Medical Center between 2003 and 2010 was reviewed. Awake craniotomy was considered a failure if conversion to general anesthesia was ...
Tópico(s): Head and Neck Surgical Oncology
2012 - American Association of Neurological Surgeons | Journal of neurosurgery
Stefano Masoli, Diana Sánchez-Ponce, Nora Vrieler, Karin Abu-Haya, Vitaly Lerner, Tal Shahar, Hermina Nedelescu, Martina Francesca Rizza, Ruth Benavides‐Piccione, Javier DeFelipe, Yosef Yarom, Alberto Muñoz, Egidio D’Angelo,
Abstract Purkinje cells in the cerebellum are among the largest neurons in the brain and have been extensively investigated in rodents. However, their morphological and physiological properties remain poorly understood in humans. In this study, we utilized high-resolution morphological reconstructions and unique electrophysiological recordings of human Purkinje cells ex vivo to generate computational models and estimate computational capacity. An inter-species comparison showed that human Purkinje ...
Tópico(s): Vestibular and auditory disorders
2024 - Nature Portfolio | Communications Biology
Revital Nimri, Eran Atlas, Michal Ajzensztejn, Shahar Miller, Tal Oron, Moshe Phillip,
Artificial pancreas systems may offer a potential major impact on the normalization of metabolic control and preventing hypoglycemic events. This study aims to establish near-normal overnight glucose control and reduce the risk of nocturnal hypoglycemia using the MD-Logic Artificial Pancreas (MDLAP), an algorithm that was developed by our research group. This inpatient feasibility study is the first step towards implementing an overnight closed-loop MDLAP system at the patient's home.Seven patients ...
Tópico(s): Diabetes and associated disorders
2012 - Mary Ann Liebert, Inc. | Diabetes Technology & Therapeutics
Sella Nevo, Efrat Morin, Adi Gerzi Rosenthal, Asher Metzger, Chen Barshai, Dana Weitzner, Dafi Voloshin, Frederik Kratzert, Gal Elidan, Gideon Dror, Gregory Begelman, Grey Nearing, Guy Shalev, Hila Noga, Ira Shavitt, Liora Yuklea, Moriah Royz, Niv Giladi, Nofar Peled Levi, Ofir Reich, Oren Gilon, Ronnie Maor, Shahar Timnat, Tal Shechter, Владимир Анисимов, Yotam Gigi, Yuval Levin, Zach Moshe, Zvika Ben-Haim, Avinatan Hassidim, Yossi Matias,
Abstract. Google's operational flood forecasting system was developed to provide accurate real-time flood warnings to agencies and the public with a focus on riverine floods in large, gauged rivers. It became operational in 2018 and has since expanded geographically. This forecasting system consists of four subsystems: data validation, stage forecasting, inundation modeling, and alert distribution. Machine learning is used for two of the subsystems. Stage forecasting is modeled with the long short- ...
Tópico(s): Hydrology and Watershed Management Studies
2022 - Copernicus Publications | Hydrology and earth system sciences
Amanda E. Bates, Richard B. Primack, Brandy S. Biggar, Tomas J. Bird, Mary E. Clinton, Rylan J. Command, Cerren Richards, Marc J. Shellard, Nathan R. Geraldi, Valeria Vergara, Orlando Acevedo‐Charry, Zuania Colón-Piñeiro, David Ocampo, Natalia Ocampo‐Peñuela, Lina María Sánchez‐Clavijo, Mihai Adamescu, Sorin Cheval, Tudor Racoviceanu, Matthew Adams, Egide Kalisa, Vincent Z. Kuuire, Vikram Aditya, Pia Anderwald, Samuel Wiesmann, Sonja Wipf, Gal Badihi, Matthew G. Henderson, Hanspeter Loetscher, Katja Baerenfaller, Lisandro Benedetti‐Cecchi, Fabio Bulleri, Iacopo Bertocci, Elena Maggi, Luca Rindi, Chiara Ravaglioli, Kristina Boerder, Julien Bonnel, Delphine Mathias, Philippe Archambault, Laurent Chauvaud, Camrin D. Braun, Simon R. Thorrold, Jacob W. Brownscombe, Jonathan D. Midwood, Christine M. Boston, Jill L. Brooks, Steven J. Cooke, Victor China, Uri Roll, Jonathan Belmaker, Assaf Zvuloni, Marta Coll, Miquel Ortega Cerdà, Brendan Connors, Lisa Lacko, Dinusha R.M. Jayathilake, Mark J. Costello, Theresa M. Crimmins, LoriAnne Barnett, Ellen G. Denny, Katharine L. Gerst, Robyn L. Marsh, Erin E. Posthumus, Reilly Rodriguez, Alyssa Rosemartin, Sara Schaffer, Jeff Switzer, Kevin M. Wong, Susan J. Cunningham, Petra Sumasgutner, Arjun Amar, Robert L. Thomson, Miqkayla Stofberg, Sally Hofmeyr, Jessleena Suri, Rick D. Stuart‐Smith, Paul B. Day, Graham J. Edgar, Antonia T. Cooper, Fabio C. De Léo, Grant Garner, Paulson G. Des Brisay, Michael B. Schrimpf, Nicola Koper, Michael Diamond, Ross G. Dwyer, Cameron J. Baker, Craig E. Franklin, Ron Efrat, Oded Berger‐Tal, Ohad Hatzofe, Vı́ctor M. Eguı́luz, Jorge Rodríguez, Juan Fernández-Gracia, David Elustondo, Vicent Calatayud, Philina A. English, Stephanie K. Archer, Sarah E. Dudas, Dana Haggarty, Austin J. Gallagher, Brendan D. Shea, Oliver N. Shipley, Ben L. Gilby, Jasmine Ballantyne, Andrew D. Olds, Christopher J. Henderson, Thomas A. Schlacher, William D. Halliday, Nicholas A. Brown, Mackenzie B. Woods, Sigal Balshine, Francis Juanes, Mitchell J. Rider, Patricia S. Albano, Neil Hammerschlag, Graeme C. Hays, Nicole Esteban, Yuhang Pan, Guojun He, Takanao Tanaka, Marc J. S. Hensel, Robert J. Orth, Christopher J. Patrick, Jonas Hentati‐Sundberg, Olof Olsson, Margot Hessing‐Lewis, Nicholas D. Higgs, Mark A. Hindell, Clive R. McMahon, Robert Harcourt, Christophe Guinet, Sarah E. Hirsch, Justin R. Perrault, Shelby R. Hoover, Jennifer D. Reilly, Catherine Hobaiter, Thibaud Gruber, Charlie Huveneers, Vinay Udyawer, Thomas M. Clarke, Laura P. Kroesen, David S. Hik, Seth G. Cherry, Justin Del Bel Belluz, Jennifer M. Jackson, Shengjie Lai, Clayton T. Lamb, Gregory LeClair, Jeffrey R. Parmelee, Matthew W. H. Chatfield, Cheryl Frederick, Sang-Don Lee, Hyomin Park, Jaein Choi, Frédéric LeTourneux, Thierry Grandmont, Frédéric Dulude de-Broin, Joël Bêty, Gilles Gauthier, Pierre Legagneux, Jesse S. Lewis, Jeffrey Haight, Liu Zhu, Jarod Lyon, Robin Hale, Dallas D’Silva, Ian MacGregor‐Fors, Enrique Arbeláez‐Cortés, Felipe A. Estela, Camilo E. Sánchez-Sarria, Michelle García-Arroyo, Giann K. Aguirre-Samboní, Juan C. Franco Morales, Shahar Malamud, Tal Gavriel, Yehezkel Buba, Shira Salingré, Mai Lazarus, Ruthy Yahel, Yigael Ben Ari, Eyal Miller, Rotem Sade, Guy Lavian, Ziv Birman, Manor Gury, Harel Baz, Ilia Baskin, A. E. Penn, Amit Dolev, Ogen Licht, Tabi Karkom, Sharon Davidzon, Avi Berkovitch, Ofer Yaakov, Raoul Manenti, Emiliano Mori, Gentile Francesco Ficetola, Enrico Lunghi, David March, Brendan J. Godley, Cecilia Martin, S. F. Mihaly, David R. Barclay, Dugald Thomson, Richard Dewey, Jeannette Bedard, Aroha Miller, Amber Dearden, Jennifer Chapman, Lauren Dares, Laura Borden, Donna Gibbs, Jessica Schultz, Nikita Sergeenko, Fiona Francis, Amanda Weltman, Nicolás Moity, Jorge Ramírez-González, Gonzalo Mucientes, Alexandre Alonso‐Fernández, Itai Namir, Avi Bar‐Massada, Chen Ron, Shmulik Yedvab, Thomas A. Okey, Steffen Oppel, Volen Arkumarev, Samuel Bakari, Vladimir Dobrev, Victoria Saravia, Anastasios Bounas, Dobromir Dobrev, Elżbieta Kret, Solomon Mengistu, Cloé Pourchier, Alazar Ruffo, Million Tesfaye, Mengistu Wondafrash, Stoyan C. Nikolov, Charles Palmer, Lorenzo Sileci, Patrick T. Rex, Christopher G. Lowe, Francesc Peters, Matthew K. Pine, Craig A. Radford, Louise Wilson, Lauren McWhinnie, Alessia Scuderi, Andrew Jeffs, Kathleen L. Prudic, Maxim Larrivée, Kent P. McFarland, Rodrigo Solis, Rebecca Hutchinson, Nuno Queiroz, Miguel Furtado, David W. Sims, Emily J. Southall, Claudio A. Quesada-Rodriguez, Jessica P. Diaz-Orozco, Ku‘ulei S. Rodgers, Sarah J. L. Severino, Andrew T. Graham, Matthew P. Stefanak, Elizabeth M. P. Madin, Peter G. Ryan, Kyle Maclean, Eleanor A. Weideman, Çağan H. Şekercioğlu, Kyle D. Kittelberger, Josip Kusak, Jeffrey A. Seminoff, Megan E. Hanna, Takahiro Shimada, Mark G. Meekan, M. Kyle S. Smith, Mohlamatsane Mokhatla, Malcolm C. K. Soh, Roanna Y.T. Pang, Breyl X.K. Ng, Benjamin P. Y.‐H. Lee, Adrian H. B. Loo, Kenneth B. H. Er, Gabriel Barros Gonçalves de Souza, Christopher D. Stallings, Joseph S. Curtis, Meaghan E. Faletti, Jonathan A. Peake, Michael J. Schram, Kara R. Wall, Carina Terry, Matt Rothendler, Lucy Zipf, Juan Sebastián Ulloa,
The global lockdown to mitigate COVID-19 pandemic health risks has altered human interactions with nature. Here, we report immediate impacts of changes in human activities on wildlife and environmental threats during the early lockdown months of 2020, based on 877 qualitative reports and 332 quantitative assessments from 89 different studies. Hundreds of reports of unusual species observations from around the world suggest that animals quickly responded to the reductions in human presence. However, ...
Elsevier BV
David Gokhman, Malka Nissim‐Rafinia, Lily Agranat-Tamir, Genevieve Housman, Raquel García-Pérez, Esther Lizano, Olivia Cheronet, Swapan Mallick, Maria A. Nieves‐Colón, Heng Li, Songül Alpaslan-Roodenberg, Mario Novak, Hongcang Gu, Jason M. Osinski, Manuel Ferrando-Bernal, Pere Gelabert, Iddi Lipende, Deus Mjungu, Ivanela Kondova, Ronald E. Bontrop, Ottmar Kullmer, Gerhard W. Weber, Tal Shahar, Mona Dvir‐Ginzberg, Marina Faerman, Ellen E. Quillen, Alexander Meissner, Yonatan Lahav, Leonid Kandel, Meir Liebergall, María E. Prada, Julio M. Vidal, Richard M. Gronostajski, Anne C. Stone, Benjamin Yakir, Carles Lalueza‐Fox, Ron Pinhasi, David Reich, Tomás Marquès‐Bonet, Eran Meshorer, Liran Carmel,
Abstract Changes in potential regulatory elements are thought to be key drivers of phenotypic divergence. However, identifying changes to regulatory elements that underlie human-specific traits has proven very challenging. Here, we use 63 reconstructed and experimentally measured DNA methylation maps of ancient and present-day humans, as well as of six chimpanzees, to detect differentially methylated regions that likely emerged in modern humans after the split from Neanderthals and Denisovans. We ...
Tópico(s): Forensic and Genetic Research
2020 - Nature Portfolio | Nature Communications
Ravit Edelman, Yehuda G. Assaraf, Anton Slavkin, Tamar Dolev, Tal Shahar, Yoav D. Livney,
Ovarian cancer mortality is the highest among gynecologic malignancies. Hence, the major challenges are early diagnosis and efficient targeted therapy. Herein, we devised model theranostic nanoparticles (NPs) for combined diagnostics and delivery of chemotherapeutics, targeted to ovarian cancer cells. These NPs were made of natural biocompatible and biodegradable body components: hyaluronic acid (HA) and serum albumin (SA). The hydrophilic HA served as the targeting ligand for cancer cells overexpressing ...
Tópico(s): Proteoglycans and glycosaminoglycans research
2019 - Multidisciplinary Digital Publishing Institute | Pharmaceutics
Naama Hirsch, Reut Eshel, Reut Bar Yaacov, Tal Shahar, Fania Shmulevich, Idit Dahan, Noam Levaot, Tommy Kaplan, Darío G. Lupiáñez, Ramon Y. Birnbaum,
The transcription factor TWIST1 plays a vital role in mesoderm development, particularly in limb and craniofacial formation. Accordingly, haploinsufficiency of TWIST1 can cause limb and craniofacial malformations as part of Saethre-Chotzen syndrome. However, the molecular basis of TWIST1 transcriptional regulation during development has yet to be elucidated. Here, we characterized active enhancers in the TWIST1-HDAC9 locus that drive transcription in the developing limb and branchial arches. Using ...
Tópico(s): Genomics and Chromatin Dynamics
2018 - Public Library of Science | PLoS Genetics
Javier Figueroa, Lynette M. Phillips, Tal Shahar, Anwar Hossain, Joy Gumin, Hoon Kim, Andrew J. Bean, George A. Călin, Juàn Fueyo, Edgar T. Walters, Raghu Kalluri, Roel G.W. Verhaak, Frederick F. Lang,
Tumor-stromal communications impact tumorigenesis in ways that are incompletely understood. Here, we show that glioma-associated human mesenchymal stem cells (GA-hMSC), a newly identified stromal component of glioblastoma, release exosomes that increase the proliferation and clonogenicity of tumor-initiating glioma stem-like cells (GSC). This event leads to a significantly greater tumor burden and decreased host survival compared with untreated GSCs in orthotopic xenografts. Analysis of the exosomal ...
Tópico(s): MicroRNA in disease regulation
2017 - American Association for Cancer Research | Cancer Research
Tal Shahar, Akiva Korn, Gal Barkay, Tali Biron, Amir Hadanny, Tomer Gazit, Erez Nossek, Margaret Ekstein, Anat Kesler, Zvi Ram,
OBJECTIVE Resection of intraaxial tumors adjacent to the optic radiation (OR) may be associated with postoperative visual field (VF) deficits. Intraoperative navigation using MRI-based tractography and electrophysiological monitoring of the visual pathways may allow maximal resection while preserving visual function. In this study, the authors evaluated the value of visual pathway mapping in a series of patients undergoing awake craniotomy for tumor resection. METHODS A retrospective analysis of prospectively ...
Tópico(s): Traumatic Brain Injury and Neurovascular Disturbances
2017 - American Association of Neurological Surgeons | Journal of neurosurgery
Ben Shofty, Moran Artzi, Dafna Ben Bashat, Gilad Liberman, Oz Haim, Alon Kashanian, Felix Bokstein, Deborah T. Blumenthal, Zvi Ram, Tal Shahar,
Tópico(s): MRI in cancer diagnosis
2017 - Springer Science+Business Media | International Journal of Computer Assisted Radiology and Surgery
Efrat Gelerstein, Assaf Berger, Tali Jonas‐Kimchi, Ido Strauss, Andrew A. Kanner, Deborah T. Blumenthal, Maya Gottfried, Nevo Margalit, Zvi Ram, Tal Shahar,
Abstract The treatment of refractory meningiomas remains a challenge for both neurosurgeons and neuro-oncologists. There have been no clinical reports of the use or effects of anti-PD-1 therapy in patients with meningioma. We describe a patient whose intracranial meningioma decreased significantly in size after treatment with nivolumab, a monoclonal antibody targeting PD-1, for a concomitant advanced lung cancer. This is the first clinical report suggesting that antibodies targeting PD-1 are effective in ...
Tópico(s): Glioma Diagnosis and Treatment
2017 - Elsevier BV | Journal of Clinical Neuroscience
Frederick Lang, Anwar Hossain, Joy Gumin, Eric Momin, Yuzaburo Shimizu, Dan Ledbetter, Tal Shahar, Shinji Yamashita, Brittany Parker Kerrigan, Juàn Fueyo, Raymond Sawaya, Frederick F. Lang,
MicroRNAs (miRs) are promising new therapeutics for glioblastoma. However, which miRs are most effective against glioblastomas and how these miRs should be delivered are major unanswered problems. To identify potent antiglioma miRs, we selected 8 miRs based on a literature search and screened them against a panel of glioma stem cell (GSC) lines, representing all of the glioblastoma subtypes defined by The Cancer Genome Atlas. To address delivery, we tested the hypothesis that ex vivo cultured bone ...
Tópico(s): MicroRNA in disease regulation
2017 - Oxford University Press | Neuro-Oncology
Tal Shahar, Uri Rozovski, Kenneth R. Hess, Anwar Hossain, Joy Gumin, Feng Gao, Gregory N. Fuller, Lindsey D. Goodman, Erik P. Sulman, Frederick F. Lang,
Human mesenchymal stem cells (hMSCs) have been shown to reside as stromal cells in human gliomas as glioma-associated hMSCs (GA-hMSCs), but their biological role remains unclear. Because recent evidence indicates that GA-hMSCs drive tumor cell proliferation and stemness, we hypothesized that a higher percentage of GA-hMSCs in tumors predicts poor patient prognosis.We determined the percentage of cells coexpressing GA-hMSC markers CD105+/CD73+/CD90+ from patients with newly diagnosed high-grade glioma ...
Tópico(s): MicroRNA in disease regulation
2016 - Oxford University Press | Neuro-Oncology
Tal Shahar, Avital Granit, Daniel Zrihan, Tamar Canello, Hanna Charbit, Ofira Einstein, Uri Rozovski, Sharona Elgavish, Zvi Ram, Tali Siegal, Iris Lavon,
Tópico(s): Cancer-related molecular mechanisms research
2016 - Springer Science+Business Media | Journal of Neuro-Oncology
Tehila Shahar, Noam Tal, Daniel Mandler,
Molecularly imprinted polymer (MIP) particles offer many advantages as recognition objects. Therefore, we examined thoroughly the effect of various experimental parameters including cross-linker concentration, nature of solvent, type of template and its concentration, reaction volume and temperature on the formation of particulate MIPs using precipitation polymerization. The particles were characterized by various methods, such as XHR-SEM, HR-TEM and BET. Statistical calculations were carried out ...
Tópico(s): Forensic Toxicology and Drug Analysis
2016 - Elsevier BV | Colloids and Surfaces A Physicochemical and Engineering Aspects