E. Teng, P.T. Manser, Maulik V. Shah, K. Pickthorn, Na Hu, S. Djakovic, H. Swendsen, M. Blendstrup, G. Faccin, Susanne Ostrowitzki, K.M. Sink,
... clinical trials for crenezumab (CREAD, CREAD2) or semorinemab (Tauriel). Cross-sectional analyses of screening data for episodic ... impairment included participants from CREAD2 (n=2897) and Tauriel (n=887) and for Aβ positivity included participants from CREAD (n=1138), CREAD2 (n=1119), and Tauriel (n=483). Longitudinal analyses of rates of clinical ... from CREAD (n=779), CREAD2 (n=773), and Tauriel (n=331).Cross-sectional analyses examined eligibility rates ... defined for the FCSRT (CREAD, CREAD2) or RBANS (Tauriel) and per Aβ positivity using CSF and/or ...
Tópico(s): Health, Environment, Cognitive Aging
2022 - Springer Science+Business Media | The Journal of Prevention of Alzheimer s Disease
Bruno P. Imbimbo, Claudia Balducci, Stefania Ippati, Mark Watling,
... of semorinemab in 457 subjects with early AD (TAURIEL study), the antibody elicited maximal increases in plasma ...
Tópico(s): Dementia and Cognitive Impairment Research
2022 - Medknow | Neural Regeneration Research
Jessica Robin, Mengdan Xu, Aparna Balagopalan, Jekaterina Novikova, Laura H. Kahn, Abdi Oday, Mohsen Hejrati, Somaye Hashemifar, Mohammadreza Negahdar, Bill Simpson, Edmond Teng,
... mean age=69 years, SD=7) from the Tauriel trial of semorinemab in prodromal‐to‐mild AD. ...
Tópico(s): Voice and Speech Disorders
2022 - Wiley | Alzheimer s & Dementia
Claire J. Lansdall, Edmond Teng, Jerome Chague, Rohan Palanganda, Paul Delmar, Janice Smith, Jeffrey L. Cummings, Fiona McDougall,
... MWPC on the CDR‐SB in early AD (Tauriel; NCT03289143) using Caregiver Global Impression of Change in ...
Tópico(s): Clinical practice guidelines implementation
2024 - Wiley | Alzheimer s & Dementia
Edmond Teng, Paul T. Manser, Karen Pickthorn, Mira Blendstrup, Neha Anegondi, Anithapriya Krishnan, Zhuang Song, Richard A.D. Carano, Michael Keeley, Kristin R. Wildsmith, Robby M. Weimer, Sandra Sanabria Bohórquez,
... by examining baseline data from the Phase 2 Tauriel study (NCT03289143), which is investigating the safety and ... Method We analyzed data from a subset of Tauriel participants who underwent baseline [ 18 F]GTP1 tau ... with prodromal‐to‐mild AD enrolled in the Tauriel study, [ 18 F]GTP1 tau PET signal was ...
Tópico(s): S100 Proteins and Annexins
2020 - Wiley | Alzheimer s & Dementia
Marina Ritchie, Seema Datta, Claire J. Lansdall, Cecília Monteiro, Balázs I. Tóth, Edmond Teng,
... used data from two phase 2 semorinemab trials, Tauriel (NCT03289143; early AD) and Lauriet (NCT03828747; mild‐to‐ ... Week 61 for Lauriet, and Week 73 for Tauriel. To determine meaningful change thresholds, we analyzed the ... in Lauriet (mild‐to‐moderate AD) compared to Tauriel (early AD) and at later time points in ...
Tópico(s): Health Systems, Economic Evaluations, Quality of Life
2024 - Wiley | Alzheimer s & Dementia
Marina Ritchie, Seema Datta, Cecília Monteiro, Balázs I. Tóth, Edmond Teng,
... data from two phase II trials of semorinemab, Tauriel (prodromal‐to‐mild AD; NCT03289143) and Lauriet (mild‐ ... the association between study partner type and retention (Tauriel: p = 0.011, Lauriet: p = 0.015; combined: ... of trial completion compared to domestic partners in Tauriel (OR: 0.21; CI: 0.06, 0.74) ...
Tópico(s): Global Health Workforce Issues
2024 - Wiley | Alzheimer s & Dementia
Edmond Teng, Yihao Li, Mira Blendstrup, Claire J. Lansdall,
... versus interventional studies, we analyzed data from the Tauriel study of semorinemab in MCI and mild dementia ... and mild dementia (n = 288) cohorts of the Tauriel study, exploring formal healthcare usage (hospital admissions, emergency ...
Tópico(s): Geriatric Care and Nursing Homes
2023 - Wiley | Alzheimer s & Dementia
Paul T. Manser, Sandra Sanabria Bohórquez, Kristin R. Wildsmith, Balázs I. Tóth, Mira Blendstrup, Karen Pickthorn, Edmond Teng,
Abstract Background The Tauriel Study (NCT03289143) was a Phase 2 randomized, double‐blind, placebo‐controlled, parallel‐group clinical trial that assessed the safety ... 14, range = [‐0.34, 0.37]). Conclusion The Tauriel trial successfully enrolled a prodromal‐to‐mild AD ...
Tópico(s): Alzheimer's disease research and treatments
2021 - Wiley | Alzheimer s & Dementia
Balázs I. Tóth, Edmond Teng, Paul T. Manser, Sandra Sanabria Bohórquez, Stephen Schauer, Julie Lee, Mira Blendstrup, Karen Pickthorn, Kristin R. Wildsmith,
Abstract Background The Tauriel Study (NCT03289143) was a Phase 2 randomized, double‐blind, placebo‐controlled, parallel‐group clinical trial that assessed the safety ...
Tópico(s): Dementia and Cognitive Impairment Research
2021 - Wiley | Alzheimer s & Dementia
Claire J. Lansdall, Edmond Teng, Fiona McDougall, Paul Delmar, Janice Smith, Paul T. Manser,
... clinical trial. Method Anchor‐based analyses of the Tauriel data (NCT03289143) were conducted to establish CDR‐SB ...
Tópico(s): Health Systems, Economic Evaluations, Quality of Life
2022 - Wiley | Alzheimer s & Dementia
Sandra Sanabria Bohórquez, Paul T. Manser, Suzanne L. Baker, Mira Blendstrup, Karen Pickthorn, Edmond Teng,
... F]GTP1 scans in the semorinemab Phase 2 Tauriel study (NCT03289143). Quantification was performed using the cerebellum ...
Tópico(s): Advanced MRI Techniques and Applications
2022 - Wiley | Alzheimer s & Dementia
Gorker Alp Malazgirt, Osman Ünsal, Adrián Cristal Kestelman,
Tópico(s): Advanced Neural Network Applications
2019 - | Book of Abstracts Student Research
Paul T. Manser, Edmond Teng, Karen Pickthorn, Mira Blendstrup, Neha Anegondi, Anithapriya Krishnan, Zhuang Song, Richard A.D. Carano, Michael Keeley, Kristin R. Wildsmith, Robby M. Weimer, Sandra Sanabria Bohórquez,
... 2 study of the anti‐tau antibody semorinemab (Tauriel; NCT03289143), which included both MRI and [ 18 F]GTP1 tau PET imaging. Method Participants in the Tauriel study are aged 50‐80, meet criteria for ... D, t‐tests, and multiple linear regression. Result Tauriel participants had Fazekas scores of zero (n=161), ... mild AD participants at screening/baseline in the Tauriel study, the relationships between MRI WMH and [ 18 ...
Tópico(s): Dementia and Cognitive Impairment Research
2020 - Wiley | Alzheimer s & Dementia
Nancy E. Ruiz‐Uribe, Paul T. Manser, Sandra Sanabria Bohórquez, Suzanne L. Baker, Cecília Monteiro, Edmond Teng,
... cognitive and functional measures in the Phase 2 Tauriel study of semorinemab in prodromal‐to‐mild AD. Methods We analyzed data from a subset of Tauriel participants with prodromal AD (pAD; n=127) or ... no treatment effects were observed with semorinemab in Tauriel, data were pooled across semorinemab and placebo arms. ...
Tópico(s): S100 Proteins and Annexins
2022 - Wiley | Alzheimer s & Dementia
Nancy E. Ruiz‐Uribe, Paul T. Manser, Sandra Sanabria Bohórquez, Suzanne L. Baker, Cecília Monteiro, Edmond Teng,
... cognitive and functional measures in the Phase 2 Tauriel study of semorinemab in prodromal‐to‐mild AD. Methods We analyzed data from a subset of Tauriel participants with prodromal AD (pAD; n=127) or ... no treatment effects were observed with semorinemab in Tauriel, data were pooled across semorinemab and placebo arms. ...
Tópico(s): S100 Proteins and Annexins
2022 - Wiley | Alzheimer s & Dementia
... AD CSF samples were from participants enrolled in Tauriel or Lauriet, two semorinemab PhII trials. Baseline protein ... F]GTP1 SUVR values were available from 128 Tauriel or Lauriet participants at baseline. The correlation analysis ...
Tópico(s): S100 Proteins and Annexins
2024 - Wiley | Alzheimer s & Dementia
Michael J. Spilka, Mengdan Xu, Balázs I. Tóth, Somaye Hashemifar, Rainier Amora, Jessica Robin, Edmond Teng, Cecília Monteiro, William Simpson,
... patients with prodromal‐to‐mild AD from the Tauriel Phase 2 study [NCT03289143]). We then compared the ...
Tópico(s): Delphi Technique in Research
2024 - Wiley | Alzheimer s & Dementia
Jessica Robin, Mengdan Xu, Abdi Oday, Cecília Monteiro, Kai Liu, Laura H. Kahn, Mohsen Hejrati, Rainier Amora, Bill Simpson, Edmond Teng,
... 53‐80) in the semorinemab (NCT03289143) Phase 2 Tauriel study. Recordings of the CDR interview were analyzed ...
Tópico(s): Voice and Speech Disorders
2021 - Wiley | Alzheimer s & Dementia
Naresh M. Punjabi, Daniel J. Gottlieb,
... tau antibody, for Alzheimer disease. The phase 2 Tauriel study showed that, in people with prodromal-to- ...
Tópico(s): Cardiovascular and Diving-Related Complications
2022 - Elsevier BV | CHEST Journal