... de investigación dedicado en exclusividad al hermano de Teodorico II. Empero, fuentes tardo-antiguas tan esenciales como Hidacio, ...
Tópico(s): Historical and Religious Studies of Rome
2020 - University of Seville | HABIS
Produção Nacional
Revisado por pares
Katia Júlia de Almeida, Teodorico C. Ramalho, Žilvinas Rinkevičius, Olav Vahtras, Hans Ågren, Amary César,
Specific and basicity solvent effects on the visible near-infrared electronic transitions and the electron paramagnetic resonance (EPR) parameters of the copper(II) acetylacetonate complex, Cu(acac)2, have been investigated at the density functional theory level. The computed absorption transitions as well as the EPR parameters show a strong dependence on the direct coordination environment around the Cu(II) complex. High solvatocromic shifts are observed for 3d-3d transitions, with the highest effect ...
Tópico(s): Magnetism in coordination complexes
2011 - American Chemical Society | The Journal of Physical Chemistry A
Produção Nacional
Revisado por pares
Danielle Rodrigues Garcia, Felipe Rodrigues de Souza, Ana Paula de Campos Guimarães, Teodorico C. Ramalho, Alcino Palermo de Aguiar, Tanos C. C. França,
Acknowledging the importance of studies toward the development of measures against terrorism and bioterrorism, this study aims to contribute to the design of new prototypes of potential drugs against smallpox. Based on a former study, nine synthetic feasible prototypes of selective inhibitors for thymidylate kinase from
Tópico(s): Bacillus and Francisella bacterial research
2018 - Taylor & Francis | Journal of Biomolecular Structure and Dynamics
Produção Nacional
Revisado por pares
Katia Júlia de Almeida, Teodorico C. Ramalho, Mirelly Caroline Alves, Olav Vahtras,
Abstract The density functional theory calculations were performed to investigate the specific solvent effects on the optical absorption spectrum of copper(II) hexafluoroacetylacetonate complex in pyridine. The effects of single and double coordination of pyridine molecules at axial position of bis(hexafluoroacetylacetonate) copper(II) indicate that both positions and intensities of 3d–3d electronic transitions are strongly dependent on the coordination environment around the copper(II) complex. ...
Tópico(s): Chemical Thermodynamics and Molecular Structure
2011 - Wiley | International Journal of Quantum Chemistry
Produção Nacional
Revisado por pares
Alexandre C. Bertoli, Ruy Inácio Neiva de Carvalho, Matheus P. Freitas, Teodorico C. Ramalho, Daiana T. Mancini, M. Conceição Oliveira, Amarílis de Varennes, Ana Paula Soares Dias,
The combined use of ESI-MS and theoretical calculations for the determination of zinc:citrate structures are reported. Mass spectrometry allowed to determine the stoichiometry 1:1 and 2:1 of the complexes, corroborating the theoretical calculations. The species found in the ratio 2:1 had their molecular structures readjusted, since the deprotonation of citric acid differed from what was simulated. The thermodynamic stability (ΔH0(aq.)) of the complexes optimized at the B3LYP/LANL2DZ level was more ...
Tópico(s): Chemical and Physical Properties in Aqueous Solutions
2014 - Elsevier BV | Inorganica Chimica Acta
Produção Nacional
Revisado por pares
Ander Francisco Pereira, Ingrid G. Prandi, Teodorico C. Ramalho,
Abstract Understanding the ways of interaction of a drug with a biological target is crucial in the pharmacology field. One methodology that allows the simulation of new drugs under in vitro conditions is the classical molecular dynamics (MD) method. However, MD simulations in systems containing metallodrugs are challenging due to the lack of specific parameters found in the literature. In this work, we propose and model a new possible anticancer platinum(II) complex: cis‐dichloro(2‐aminomethylpyridine) ...
Tópico(s): Nonlinear Optical Materials Research
2020 - Wiley | International Journal of Quantum Chemistry
Adriano Leccia, Mohamed Sallam, Stanislao Grazioso, Teodorico Caporaso, Giuseppe Di Gironimo, Fanny Ficuciello,
Artificial limbs can help people missing body parts to restore some of their daily-life activities. However, the user should spend up to a few months to intuitively control the new device. During this period, she/he may suffer pain due to wearing or using the prosthesis inappropriately. This research presents a virtual simulator that allows the user to carry out training sessions for controlling the prosthesis. A set of Surface Electromyographic (sEMG) sensors are used to acquire the signals from ...
Tópico(s): Neuroscience and Neural Engineering
2023 - Elsevier BV | Engineering Applications of Artificial Intelligence
Produção Nacional
Revisado por pares
Letícia Casagrande Dal Bello, Luana Ferreira Graziano, Célio Teodorico, Fabiana Passos Rodrigues, Ricardo de Moura Mendonça, Fabíola Barbosa Beltrão,
Objetiva a análise emocional da camisa do time de futebol Chapecoense, denominada Camisa Chapecoense II 2018 s/nº La Pasion, que utiliza das cores da bandeira da Colômbia com o escudo da Chapecoense, em forma de homenagem remetendo ao apoio dado no acidente aéreo ocorrido no país no ano de 2016. Conduziu-se um questionário com 14 emoções relacionadas ao design emocional a fim de obter dados para a compreensão sobre o assunto. Evidenciou que 82% dos participantes da pesquisa eram torcedores do time ...
Tópico(s): Physical Education and Gymnastics
2019 - UNIVERSIDADE DO ESTADO DE SANTA CATARINA | DAPesquisa
Produção Nacional
Revisado por pares
Thaís Aparecida Sales, Teodorico C. Ramalho,
Tópico(s): Antibiotics Pharmacokinetics and Efficacy
2022 - Springer Science+Business Media | Theoretical Chemistry Accounts
Tópico(s): Libraries, Manuscripts, and Books
1981 - Brill | Annali dell Istituto e Museo di storia della scienza di Firenze
... of the most important surgeon–authors, such as Teodorico Borgognoni, Hugh of Lucca, Henri of Mondeville, and John Aderne, and concludes with a brief consideration of modern practices. Part II contains two closely related essays. Warr considers medieval ...
Tópico(s): History of Medicine Studies
2015 - Australian and New Zealand Association for Medieval and Early Modern Studies | Parergon
Produção Nacional
Revisado por pares
Regina Mitsuka, Italmar Teodorico Navarro, Andrea Cláudia BECKNER DA SILVA, José Wander Breganó, Amauri Alcindo Alfieri, José Vítor Jankevicius, Odilon Vidotto,
que mais diferiu no perfil antigênico.Essa amostra não apresentou três antígenos (50, 70 e 75 kDa) presentes nas demais amostras.Apenas dois antígenos, um de 62 kDa da CN e outro de 67 kDa da LIV IV, foram amostra-específicos.
Tópico(s): T-cell and Retrovirus Studies
1998 - UNIVERSIDADE DE SÃO PAULO | Brazilian Journal of Veterinary Research and Animal Science
Produção Nacional
Revisado por pares
Maíra S. Pires, Telles C. Silva, Lívia C. T. Lacerda, Alexandre A. de Castro, Silviana Corrêa, I. S. Santos de Oliveira, Viviane S. Vaiss, Francisco G.E. Nogueira, Teodorico C. Ramalho,
Magnetite (Fe3O4) is considered a promising catalyst for the removal of hexavalent chromium (Cr VI) in wastewater. To optimize its adsorptive capacity, bivalent copper ions (Cu II) were added to the oxide matrix. Structural and electronic properties, as well as chromate adsorption processes (CrO42-), were investigated by the density functional theory method with incorporating the Hubbard correction term (DFT + U). Adsorption energy data indicate that the doped magnetite, Cu/Fe3O4, performs better in removing ...
Tópico(s): Iron oxide chemistry and applications
2021 - Elsevier BV | Chemical Physics Letters
Produção Nacional
Revisado por pares
Thaís Aparecida Sales, Mateus A. Gonçalves, Teodorico C. Ramalho,
New tools for cancer diagnosis are being studied since early diagnosis can be crucial for a successful treatment. In this context, the use of NMR probes constitutes an efficient method of diagnosis. In this study, we investigated the use of ciprofloxacin to indirectly label the overexpression of topoisomerase-II enzymes by changes in 19F NMR chemical shifts of ciprofloxacin. Increased topoisomerase-II expression has been associated with cancer occurrence, mainly with aggressive forms of breast cancer, ...
Tópico(s): Lung Cancer Research Studies
2022 - Multidisciplinary Digital Publishing Institute | Magnetochemistry
Andréa Motta, Delia Picone, Teodorico Tancredi, Piero Andrea Temussi,
Leu-enkephalin (LE) and its amide (LEA) were studied by means of 1H NMR spectroscopy, at low temperatures , in one of the so-called cryoprotective mixtures (water/DMSO in particular),i.e. mixtures that resemble water in many properties and that reach high values of the viscosity. The temperature coefficients of amide protons were measured in an unusually wide temperature range (+54 to -30 °C). All values for both LE and LEA are larger than those expected for protons involved in hydrogen bonds. Owing to the ...
Tópico(s): Molecular Spectroscopy and Structure
1988 - Elsevier BV | Tetrahedron
Produção Nacional
Jamile Haddad Giraldi, Ana Paula Frederico Rodrigues Loureiro Bracarense, Odilon Vidotto, Eduardo Alberto Tudury, Italmar Teodorico Navarro, Thiago Neves Batista,
The evolvement of Toxoplasma gondii and Neospora caninum on etiology of clinical-neurological signs in dogs was investigated in this work. Ninety-eight urban dogs with neurologic disturbances were divided into two groups: Group I consisted of 67 dogs examined by the Animal Neurologic Service of Universidade Estadual de Londrina, between 1987 and 1990. Group II consisted of 31 dogs examined on the same University between 2000 and 2001. Dogs were serological evaluated for evidence of T. gondii or ...
Tópico(s): Microbial infections and disease research
2002 - UNIVERSIDADE ESTADUAL DE LONDRINA | Semina Ciências Agrárias
Produção Nacional
Revisado por pares
Renata Cristina Ferreira Dias, Fabiana Maria Ruíz Lopes-Mori, Regina Mitsuka‐Breganó, Rafael André Ferreira Dias, Deise Vieira Tokano, Edna Maria Vissoci Reiche, Roberta Lemos Freire, Italmar Teodorico Navarro,
The aim of the present work was to determine the prevalence of IgG and IgM anti-Toxoplasma gondii antibodies and the factors associated to the infection in pregnant women attended in Basic Health Units in Rolândia, Paraná, Brazil. The sample was divided in two groups: group I (320 pregnant women who were analyzed from July 2007 to February 2008) and group II (287 pregnant women who were analyzed from March to October 2008). In group I, it was found 53.1% of pregnant women with IgG reactive and IgM ...
Tópico(s): Sex work and related issues
2011 - UNIVERSIDADE DE SÃO PAULO | Revista do Instituto de Medicina Tropical de São Paulo
J. P. Dubey, Italmar Teodorico Navarro, C. Sreekumar, E. Dahl, Roberta Lemos Freire, Hisashi Kawabata, M.C.B. Vianna, O. C. H. Kwok, S. K. Shen, P. Thulliez, Tovi Lehmann,
Cats are important in the epidemiology of Toxoplasma gondii because they are the only hosts that can excrete environmentally resistant oocysts. The prevalence of T. gondii was determined in 58 domestic cats from 51 homes from Santa Isabel do Ivai, Parana State, Brazil where a water-associated outbreak of acute toxoplasmosis had occurred in humans. Antibodies to T. gondii were found with the modified agglutination test in 49 of 58 (84.4%) cats at a serum dilution of 1:20. Tissues (brain, heart, and ...
Tópico(s): Herpesvirus Infections and Treatments
2004 - American Society of Parasitologists | Journal of Parasitology
Sara Rodrigues, Alberto Teodorico Correia, Sara C. Antunes, Bruno Nunes,
In recent decades, scientific research about the effects of anthropogenic xenobiotics on non-target organisms has increased. Among the likely effects, some studies reported the evaluation of biochemical and morphological changes in specific tissues or organs of fishes, such as gills, which are key organs for the direct action of pollutants in the aquatic environment. This work intended to assess biochemical [oxidative stress/phase II conjugation isoenzymes glutathione S-transferase (GSTs)] and morphological [ ...
Tópico(s): Pesticide and Herbicide Environmental Studies
2014 - Taylor & Francis | Drug and Chemical Toxicology
Produção Nacional
Revisado por pares
Daiana T. Mancini, Eugenio F. de Souza, Melissa S. Caetano, Teodorico C. Ramalho,
The phenylbenzothiazole compounds show antitumor properties and are highly selective. In this paper, the 99 Tc chemical shifts based on the ( 99m Tc)(CO) 3 (NNO) complex conjugated to the antitumor agent 2‐(4′‐aminophenyl)benzothiazole are reported. Thermal and solvent effects were studied computationally by quantum‐chemical methods, using the density functional theory (DFT) (DFT level BPW91/aug‐cc‐pVTZ for the Tc and BPW91/IGLO‐II for the other atoms) to compute the NMR parameters for the complex. We ...
Tópico(s): Chemical Reaction Mechanisms
2014 - Wiley | Magnetic Resonance in Chemistry
✓ During Eldridge Campbell's tour of duty as the neurosurgical consultant to the Mediterranean theater of World War II operations, he was introduced to a then-revolutionary method of wound treatment. Ironically, Campbell's diligent research efforts later revealed that this method of wound treatment had first been advocated seven centuries earlier—in the same geographical location—by the Italian surgeon Theodoric. Although controversial, this method of wound care was subsequently applied and supported by ...
Tópico(s): History of Medicine Studies
1995 - American Association of Neurological Surgeons | Journal of neurosurgery
Produção Nacional
Revisado por pares
Aline M. Mesquita, Iara do Rosário Guimarães, Guilherme Mello Mattos de Castro, Mateus A. Gonçalves, Teodorico C. Ramalho, Mário César Guerreiro,
The aim of this study was to obtain iron oxides (goethite phase, α-FeOOH) to be used as Fenton catalysts in the catalytic oxidation of methylene blue (MB). Moreover surface modifications were attempted by treating the oxides with boric acid in order to improve the materials' catalytic properties through the generation of more active groups on the surface of goethite. The types of structures formed on the surface were investigated through the following characterization techniques: vibrational infrared ...
Tópico(s): Arsenic contamination and mitigation
2016 - Elsevier BV | Applied Catalysis B Environment and Energy
Sara C. Antunes, Bruno Nunes, Sara Rodrigues, Ricardo Gomes dos Santos Nunes, José O. Fernandes, Alberto Teodorico Correia,
Benzalkonium chloride (BAC) is one of the most used conservatives in pharmaceutical preparations. However, its use is limited to a small set of external use formulations, due to its high toxicity. Benzalkonium chloride effects are related to the potential exertion of deleterious effects, mediated via oxidative stress and through interaction with membrane enzymes, leading to cellular damage. To address the ecotoxicity of this specific compound rainbow trouts were chronically exposed to BAC at environmental ...
Tópico(s): Analytical chemistry methods development
2016 - Elsevier BV | Environmental Toxicology and Pharmacology
Produção Nacional
Revisado por pares
Bruno Bergamo Ruffolo, Roberta dos Santos Toledo, Felippe Danyel Cardoso Martins, Felipe Monteiro Bugni, L. Da Costa, Elizabete Regina Marangoni Marana, Italmar Teodorico Navarro, João Luís Garcia, Chunlei Su, Roberta Lemos Freire,
The role of rodents in the epidemiology of toxoplasmosis was investigated in Londrina, Paraná State, Brazil. One hundred and eighty-one Rattus rattus and one Mus musculus were caught in 37 places. Blood and tissues were collected and submitted to the indirect fluorescence antibody test (IFAT) and the bioassay. Serum samples from 61 contacting dogs were also collected. Sixteen rats (8.8%) were positive for Toxoplasma gondii, but just two of them were positive by serology and bioassay test. Antibodies ...
Tópico(s): Rabies epidemiology and control
2016 - UNIVERSIDADE DE SÃO PAULO | Revista do Instituto de Medicina Tropical de São Paulo
Produção Nacional
Revisado por pares
Marcus V. J. Rocha, Nicole W. G. Smits, Lando P. Wolters, Abel de Cózar, Célia Fonseca Guerra, Teodorico C. Ramalho, F. Matthias Bickelhaupt,
We have quantum chemically investigated the archetypal nucleophilic substitution reactions at carbon (SN[email protected]) and at silicon (SN[email protected]) in the model reaction systems Cl− + A(CH3)2(CH2X)Cl (A = C, Si; X = H, F, Cl, Br, I) using relativistic density functional theory (DFT) at ZORA-OLYP/TZ2P. Our purpose is twofold. We wish to understand: (i) how the α-substituent X affects SN2 reactivity; and (ii) how methyl substituents at the central electrophilic atom A exactly participate in the transition ...
Tópico(s): Chemical Reaction Mechanisms
2016 - Elsevier BV | International Journal of Mass Spectrometry
Produção Nacional
Revisado por pares
Diego Paschoal, Célia Fonseca Guerra, Marcone Augusto Leal de Oliveira, Teodorico C. Ramalho, Hélio F. Dos Santos,
Predicting NMR properties is a valuable tool to assist the experimentalists in the characterization of molecular structure. For heavy metals, such as Pt‐195, only a few computational protocols are available. In the present contribution, all‐electron Gaussian basis sets, suitable to calculate the Pt‐195 NMR chemical shift, are presented for Pt and all elements commonly found as Pt‐ligands. The new basis sets identified as NMR‐DKH were partially contracted as a triple‐zeta doubly polarized scheme ...
Tópico(s): Magnetism in coordination complexes
2016 - Wiley | Journal of Computational Chemistry
Produção Nacional
Revisado por pares
Alexandre A. de Castro, Melissa S. Caetano, Telles C. Silva, Daiana T. Mancini, Eduardo P. da Rocha, Elaine F. F. da Cunha, Teodorico C. Ramalho,
During World War II, organophosphorus compounds with neurotoxic action were developed and used as the basis for the development of structures currently used as pesticides in the agricultural industry. Among the nerve agents, Tabun, Sarin, Soman and VX are the most important. The factor responsible for the high toxicity of organophosphorus (OP) is the acetylcholinesterase inhibition. However, one of the characterized enzymes capable of degrading OP is Phosphotriesterase (PTE). This enzyme has generated ...
Tópico(s): Chemical Reaction Mechanisms
2016 - Bentham Science Publishers | Combinatorial Chemistry & High Throughput Screening
Produção Nacional
Revisado por pares
Dauton Luiz Zulpo, Ana Sue Sammi, Joeleni Rosa dos Santos, João Pedro Sasse, Thais Agostinho Martins, Ana Flávia Minutti, Sérgio Tosi Cardim, Luiz Daniel de Barros, Italmar Teodorico Navarro, João Luís Garcia,
The aim of the present study was to evaluate the re-shedding of T. gondii oocysts in cats fed tissue cysts of homologous and heterologous strains 12, 24 and 36 months after the first infection. Thirteen cats were used in the present study and were divided into four groups: G1 (n=2), G2 (n=3), G3 (n=5), and G4 (n=3). G1, G3 and G4 cats were infected with brain cysts of ME49 and G2 with TgDoveBr8, both genotype II strains of T. gondii. The G1 and G2 cats were re-infected after twelve months with brain ...
Tópico(s): Herpesvirus Infections and Treatments
2017 - Elsevier BV | Veterinary Parasitology
Produção Nacional
Revisado por pares
Thaís Aparecida Sales, Silvana Marcussi, Elaine Cunha, Kamil Kuča, Teodorico C. Ramalho,
Human phospholipase A2 (hPLA2) of the IIA group (HGIIA) catalyzes the hydrolysis of membrane phospholipids, producing arachidonic acid and originating potent inflammatory mediators. Therefore, molecules that can inhibit this enzyme are a source of potential anti-inflammatory drugs, with different action mechanisms of known anti-inflammatory agents. For the study and development of new anti-inflammatory drugs with this action mechanism, snake venom PLA2 (svPLA2) can be employed, since the svPLA2 has ...
Tópico(s): Healthcare and Venom Research
2017 - Multidisciplinary Digital Publishing Institute | Toxins
Sara Rodrigues, Sara C. Antunes, Alberto Teodorico Correia, Bruno Nunes,
Oxytetracycline (OTC) is a tetracycline antibiotic, widely used in human and veterinary medicines, including in aquaculture. Given this use, OTC has been detected in different aquatic environments. Some recent works have demonstrated unintentional biological activity of OTC in non-target aquatic organisms. This study investigated the acute and chronic effects of OTC on the physiology of the fish species Oncorhynchus mykiss (rainbow trout), namely through the quantification of the activity of enzymes ...
Tópico(s): Aquaculture disease management and microbiota
2018 - Elsevier BV | Ecotoxicology and Environmental Safety