Produção Nacional
Revisado por pares
Camila A. Tavares, Taináh M. R. Santos, Elaine F. F. da Cunha, Teodorico C. Ramalho,
The scarcity of efficient force fields to describe metal complexes may be a problem for new advances in medicinal chemistry. Thus, the development of force fields for these compounds can be valuable for the scientific community, especially when it comes to molecules that show interesting outputs regarding potential treating of diseases. Vanadium complexes, for instance, have shown promising results towards therapeutics of Alzheimer's Disease, most notably the bis(maltolato)oxovanadium (IV). Therefore, ...
Tópico(s): Molecular Sensors and Ion Detection
2023 - Elsevier BV | Journal of Molecular Graphics and Modelling
Produção Nacional
Revisado por pares
Daniel Fonseca de Carvalho, Eleandro Silva da Cruz, Wilson Araújo da Silva, Teodorico Alves Sobrinho,
... 0,63 a 0,86, para a fase IV. Com esses valores de Kc em comparação com ...
Tópico(s): Growth and nutrition in plants
2006 - UNIVERSIDADE FEDERAL DE CAMPINA GRANDE | Revista Brasileira de Engenharia Agrícola e Ambiental
Produção Nacional
Revisado por pares
Anna Clara Milesi Galdino, Lívia Viganor, Alexandre A. de Castro, Elaine F. F. da Cunha, Thaís P. Mello, Larissa M. M. Mattos, Marcos D. Pereira, Mary C. Hunt, Megan O’Shaughnessy, Orla Howe, Michael Devereux, Malachy McCann, Teodorico C. Ramalho, Marta H. Branquinha, André Luis Souza dos Santos,
Elastase B (lasB) is a multifunctional metalloenzyme secreted by the gram-negative pathogen Pseudomonas aeruginosa, and this enzyme orchestrates several physiopathological events during bacteria-host interplays. LasB is considered to be a potential target for the development of an innovative chemotherapeutic approach, especially against multidrug-resistant strains. Recently, our group showed that 1,10-phenanthroline-5,6-dione (phendione), [Ag(phendione)2]ClO4 (Ag-phendione) and [Cu(phendione)3](ClO4) ...
Tópico(s): Antimicrobial Peptides and Activities
2019 - Frontiers Media | Frontiers in Microbiology
Produção Nacional
Revisado por pares
Camila A. Tavares, Taináh M. R. Santos, Elaine F. F. da Cunha, Teodorico C. Ramalho,
A large part of the world’s population is affected by Alzheimer’s disease (AD) and diabetes mellitus type 2, which cause both social and economic impacts. These two conditions are associated with one protein, AMPK. Studies have shown that vanadium complexes, such as bis(N′,N′-dimethylbiguanidato)-oxovanadium(IV), VO(metf)2·H2O, are potential agents against AD. A crucial step in drug design studies is obtaining information about the structure and interaction of these complexes with the biological ...
Tópico(s): Metal complexes synthesis and properties
2023 - American Chemical Society | The Journal of Physical Chemistry B
Produção Nacional
Revisado por pares
Rodrigo Mancini Santos, Camila A. Tavares, Taináh M. R. Santos, Hassan Rasouli, Teodorico C. Ramalho,
Early phase diagnosis of human diseases has still been a challenge in the medicinal field, and one of the efficient non-invasive techniques that is vastly used for this purpose is magnetic resonance imaging (MRI). MRI is able to detect a wide range of diseases and conditions, including nervous system disorders and cancer, and uses the principles of NMR relaxation to generate detailed internal images of the body. For such investigation, different metal complexes have been studied as potential MRI ...
Tópico(s): Metal-Organic Frameworks: Synthesis and Applications
2023 - Multidisciplinary Digital Publishing Institute | Pharmaceuticals
Produção Nacional
Revisado por pares
Italmar Teodorico Navarro, Odilon Vidotto, Andréa Carlos Bekner da Silva, Regina Mitsuka, José Vítor Jankevicius, Paula Namie Shida, José de Angelis Côrtes,
A biologia do Toxoplasma gondii demonstra que o gato é o hospedeiro completo, responsável pela disseminação do parasito. Assim, dois gatos domésticos foram imunizados com cada uma das amostras, VPS (humano), LIV-IV e LIV-V (suíno), CPL (caprino) e CN (felino) de T. gondii. Foram utilizados taquizoítas vivos em inóculos endovenosos de 2x10(6) (1° inóculo} e 4x10(7) (2° inóculo - 35 dias após), exceto a amostra VPS, onde 1 gato morreu no 10° dia com sinais clínicos agudos da doença, nas outras amostras, nenhum ...
Tópico(s): Rabies epidemiology and control
1998 - UNIVERSIDADE FEDERAL DE SANTA MARIA | Ciência Rural
Produção Nacional
Neusa Maria Alves Viotti, Roberta Lemos Freire, Italmar Teodorico Navarro, Odilon Vidotto,
Six 120 days old Landrace/Large-white swines with were inoculated with taquizoites of the AS 28, LIV-IV and N Toxoplasma gondii strains and analysed under clinical, sorological, parasitological and histopathological aspects. In order to evaluate some postmortem diagnostic techniques, three swines were sacrificed in the acute phase and three swines in the chronic phase of the infection. Formalin-fixed and parafin-embedded tissues were submitted to Eosin-Hematoxilin, Indirect Immunofluorescence (IFA) ...
Tópico(s): Parasitic Infections and Diagnostics
1995 - UNIVERSIDADE ESTADUAL DE LONDRINA | Semina Ciências Agrárias
La sanción del concilio de Orange de 529, impulsada por Cesáreo de Arles y avalada por Bonifacio II, luego de un complicado traspaso en Roma, con la muerte de Félix IV y la disputa por la herencia papal entre godos y bizantinos, cristaliza las derivas dogmáticas que se venían desarrollando desde los febriles cuestionamientos a la autoridad del obispo de Hipona, irradiados especialmente a partir de los centros de disciplina monástica instalados en el sur de Galia, i. e., Marsella y Lérins, y el norte ...
Tópico(s): Byzantine Studies and History
2018 - University of Buenos Aires | Anales de Historia Antigua Medieval y Moderna
Produção Nacional
Revisado por pares
Taináh M. R. Santos, Camila A. Tavares, Elaine F. F. da Cunha, Teodorico C. Ramalho,
The modulation of autophagy has been presented as a very useful strategy in anticancer treatments. In this sense, the vanadium complex (VC) bis(2,2'-bipyridine)chlorooxovanadium(IV), [VO(bpy)2Cl], is known for its ability to induce autophagy in triple-negative breast cancer cells (TNBC). An excellent resource to investigate the role of VC in the induction of autophagy is to make use of Molecular Dynamics (MD) simulations. However, until now, the scarcity of force field parameters for the VC prevented ...
Tópico(s): Metal-Catalyzed Oxygenation Mechanisms
2023 - Taylor & Francis | Journal of Biomolecular Structure and Dynamics
... of the most important surgeon–authors, such as Teodorico Borgognoni, Hugh of Lucca, Henri of Mondeville, and ...
Tópico(s): History of Medicine Studies
2015 - Australian and New Zealand Association for Medieval and Early Modern Studies | Parergon
Produção Nacional
Revisado por pares
Regina Mitsuka, Italmar Teodorico Navarro, Andrea Cláudia BECKNER DA SILVA, José Wander Breganó, Amauri Alcindo Alfieri, José Vítor Jankevicius, Odilon Vidotto,
que mais diferiu no perfil antigênico.Essa amostra não apresentou três antígenos (50, 70 e 75 kDa) presentes nas demais amostras.Apenas dois antígenos, um de 62 kDa da CN e outro de 67 kDa da LIV IV, foram amostra-específicos.
Tópico(s): T-cell and Retrovirus Studies
1998 - UNIVERSIDADE DE SÃO PAULO | Brazilian Journal of Veterinary Research and Animal Science