Produção Nacional
Revisado por pares
Cristina Wide Pissetti, Dalmo Correia, Tárcio Teodoro Braga, Gladstone Eustáquio de Lima Faria, Rafael Faria de Oliveira, Betânia Maria Ribeiro, Denise Bertulucci Rocha Rodrigues, Virmondes Rodrigues,
A doença de Chagas é uma importante doença parasitária crônica, que acomete cerca de 9-11 milhões de pessoas na América Latina. Provavelmente, uma combinação de fatores relacionados ao parasito e ao hospedeiro podem ser os responsáveis pela patogênese na fase crônica da doença. Dentre os fatores relacionados ao hospedeiro, a resposta imunológica é um parâmetro de especial interesse. Objetivamos avaliar os níveis plasmáticos das citocinas interferon gama, interleucina 10, fator de necrose tumoral ...
Tópico(s): Toxoplasma gondii Research Studies
2009 - Brazilian Society of Tropical Medicine | Revista da Sociedade Brasileira de Medicina Tropical
Produção Nacional
Revisado por pares
Rafael Luiz Pereira, Bruna N. Buscariollo, Matheus Corrêa-Costa, Patrícia Semedo, Cassiano Donizetti de Oliveira, Vanessa O. Reis, Edgar Maquigussa, Ronaldo C. Araújo, Tárcio Teodoro Braga, Maria Fernanda Soares, Ivan Cruz Moura, Denise Maria Avancini Costa Malheiros, A. P. Silva Filho, Alexandre C. Keller, Niels Olsen Saraiva Câmara,
Focal and segmental glomerulosclerosis (FSGS) is one of the most important causes of end-stage renal failure. The bradykinin B1 receptor has been associated with tissue inflammation and renal fibrosis. To test for a role of the bradykinin B1 receptor in podocyte injury, we pharmacologically modulated its activity at different time points in an adriamycin-induced mouse model of FSGS. Estimated albuminuria and urinary protein to creatinine ratios correlated with podocytopathy. Adriamycin injection ...
Tópico(s): Mast cells and histamine
2011 - Elsevier BV | Kidney International
Produção Nacional
Lívia de Castro Magalhães, Karine Lage Fonseca, Lílian Diná Teodoro Braga Martins, Lílian de Fátima Dornelas,
OBJETIVOS: analisar o desempenho de crianças da região metropolitana Belo Horizonte/MG nascidas pré-termo com muito e extremo baixo peso nos itens do teste Denver II. MÉTODOS: as crianças foram selecionadas em um programa de acompanhamento do desenvolvimento de crianças de risco. A amostra incluiu 177 crianças, nas quais o Teste de Denver II foi aplicado nas idades corrigidas de 4, 8, 12, 18 e 24 meses. As respostas foram comparadas (χ2) aos dados da amostra normativa do instrumento. RESULTADOS: ...
Tópico(s): Maternal and Neonatal Healthcare
2011 - Instituto Materno Infantil de Pernambuco | Revista Brasileira de Saúde Materno Infantil
Produção Nacional
Revisado por pares
Matheus Corrêa-Costa, Tárcio Teodoro Braga, Patrícia Semedo, C. Y. Hayashida, Luiz R. G. Bechara, Rosa Maria Elias, Claudiene Rodrigues Barreto, C. Silva-Cunha, Meire Ioshie Hyane, Giselle Martins Gonçalves, Patrı́cia C. Brum, Clarice Kazue Fujihara, Roberto Zatz, Álvaro Pacheco‐Silva, Dario S. Zamboni, Niels Olsen Saraiva Câmara,
Tubule-interstitial nephritis (TIN) results in decreased renal function and interstitial inflammation, which ultimately leads to fibrosis. Excessive adenine intake can cause TIN because xanthine dehydrogenase (XDH) can convert this purine into an insoluble compound, which precipitates in the tubuli. Innate immune sensors, such as Toll-like receptors (TLR) and inflammasome complex, play a crucial role in the initiation of inflammation. The aim of this study was to evaluate the roles of TLR-2 and -4, ...
Tópico(s): Liver Disease and Transplantation
2011 - Public Library of Science | PLoS ONE
Produção Nacional
Revisado por pares
Giselle Martins Gonçalves, Ângela Castoldi, Tárcio Teodoro Braga, Niels Olsen Saraiva Câmara,
The innate immune system plays an important role as a first response to tissue injury. This first response is carried out via germline-encoded receptors. They can recognize exogenous Pathogen-Associated Molecular Patterns and endogenous Dangers-Associated Molecular Patterns. The Toll-Like Receptor (TLR) family is well-studied, but more recently another family in the cytoplasmic compartment, called nod-like receptor (NLR), was discovered. In addition to being present in inflammatory cells, these receptors ...
Tópico(s): Inflammasome and immune disorders
2011 - Wiley | Scandinavian Journal of Immunology
Produção Nacional
Revisado por pares
Rosa Maria Elias, Matheus Corrêa-Costa, Claudiene Rodrigues Barreto, Reinaldo Correia Silva, C. Y. Hayashida, Ângela Castoldi, Giselle Martins Gonçalves, Tárcio Teodoro Braga, Renato Barboza, Francisco J. Rios, Alexandre C. Keller, Marcos Antônio Cenedeze, Meire Ioshie Hyane, Maria Regina D’Império Lima, A. M. Figueiredo Neto, Marlene Antônia dos Reis, Cláudio Romero Farias Marinho, Álvaro Pacheco‐Silva, Niels Olsen Saraiva Câmara,
Malaria associated-acute kidney injury (AKI) is associated with 45% of mortality in adult patients hospitalized with severe form of the disease. However, the causes that lead to a framework of malaria-associated AKI are still poorly characterized. Some clinical studies speculate that oxidative stress products, a characteristic of Plasmodium infection, as well as proinflammatory response induced by the parasite are involved in its pathophysiology. Therefore, we aimed to investigate the development ...
Tópico(s): Drug-Induced Hepatotoxicity and Protection
2012 - Public Library of Science | PLoS ONE
Produção Nacional
Revisado por pares
Tárcio Teodoro Braga, Matheus Corrêa-Costa, Yuri Felipe Souza Guise, Ângela Castoldi, Cassiano Donizetti de Oliveira, Meire Ioshie Hyane, Marcos Antônio Cenedeze, Simone A. Teixeira, Marcelo N. Muscará, Katia R. Perez, Iolanda Midea Cuccovia, Álvaro Pacheco‐Silva, Giselle Martins Gonçalves, Niels Olsen Saraiva Câmara,
Inflammation contributes to the pathogenesis of chronic kidney disease (CKD). Molecules released by the inflamed injured tissue can activate toll-like receptors (TLRs), thereby modulating macrophage and CD4(+) T-cell activity. We propose that in renal fibrogenesis, M2 macrophages are recruited and activated in a T helper subset 2 cell (T(H)2)-prone inflammatory milieu in a MyD88-dependent manner. Mice submitted to unilateral ureteral ligation (UUO) demonstrated an increase in macrophage infiltration ...
Tópico(s): Phagocytosis and Immune Regulation
2012 - BioMed Central | Molecular Medicine
Produção Nacional
Revisado por pares
Ângela Castoldi, Tárcio Teodoro Braga, Matheus Corrêa-Costa, Cristhiane Fávero de Aguiar, Ênio José Bassi, Reinaldo Correa-Silva, Rosa Maria Elias, Fábia A. Salvador, Pedro M. Moraes‐Vieira, Marcos Antônio Cenedeze, Marlene Antônia dos Reis, Meire Ioshie Hiyane, Álvaro Pacheco‐Silva, Giselle Martins Gonçalves, Niels Olsen Saraiva Câmara,
The aim of this study was to investigate the role of TLR2, TLR4 and MyD88 in sepsis-induced AKI. C57BL/6 TLR2−/−, TLR4−/− and MyD88−/− male mice were subjected to sepsis by cecal ligation and puncture (CLP). Twenty four hours later, kidney tissue and blood samples were collected for analysis. The TLR2−/−, TLR4−/− and MyD88−/− mice that were subjected to CLP had preserved renal morphology, and fewer areas of hypoxia and apoptosis compared with the wild-type C57BL/6 mice (WT). MyD88−/− mice were completely ...
Tópico(s): Acute Kidney Injury Research
2012 - Public Library of Science | PLoS ONE
Produção Nacional
Revisado por pares
Matheus Corrêa-Costa, Tárcio Teodoro Braga, Raphael José Ferreira Felizardo, Vinícius Andrade‐Oliveira, Katia R. Perez, Iolanda Midea Cuccovia, Meire Ioshie Hiyane, João S. Silva, Niels Olsen Saraiva Câmara,
Macrophages play a special role in the onset of several diseases, including acute and chronic kidney injuries. In this sense, tubule interstitial nephritis (TIN) represents an underestimated insult, which can be triggered by different stimuli and, in the absence of a proper regulation, can lead to fibrosis deposition. Based on this perception, we evaluated the participation of macrophage recruitment in the development of TIN. Initially, we provided adenine-enriched food to WT and searched for macrophage ...
Tópico(s): Chronic Kidney Disease and Diabetes
2014 - Hindawi Publishing Corporation | Mediators of Inflammation
Produção Nacional
Revisado por pares
Matheus Corrêa-Costa, Vinícius Andrade‐Oliveira, Tárcio Teodoro Braga, Ângela Castoldi, Cristhiane Fávero de Aguiar, Clarice S. Origassa, Andrea C.D. Rodas, Meire Ioshie Hiyane, Denise MAC Malheiros, Francisco J. Rios, Sônia Jancar, Niels Olsen Saraiva Câmara,
Platelet-activating factor (PAF) is a lipid mediator with important pro-inflammatory effects, being synthesized by several cell types including kidney cells. Although there is evidence of its involvement in acute renal dysfunction, its role in progressive kidney injury is not completely known. In the present study, we investigated the role of PAF receptor (PAFR) in an experimental model of chronic renal disease. Wild-type (WT) and PAFR knockout (KO) mice underwent unilateral ureter obstruction (UUO), ...
Tópico(s): Renal and Vascular Pathologies
2014 - Elsevier BV | Laboratory Investigation
Produção Nacional
Revisado por pares
Cristiane Miranda da Silva, Mayara Peres Leal, Robson Alexandre Brochetti, Tárcio Teodoro Braga, Luana Beatriz Vitoretti, Niels Olsen Saraiva Câmara, Amílcar Sabino Damazo, Ana Paula Ligeiro de Oliveira, Maria Cristina Chavantes, Adriana Lino‐dos‐Santos‐Franco,
Lung diseases constitute an important public health problem and its growing level of concern has led to efforts for the development of new therapies, particularly for the control of lung inflammation. Low Level Laser Therapy (LLLT) has been highlighted as a non-invasive therapy with few side effects, but its mechanisms need to be better understood and explored. Considering that pollution causes several harmful effects on human health, including lung inflammation, in this study, we have used formaldehyde ( ...
Tópico(s): Olfactory and Sensory Function Studies
2015 - Public Library of Science | PLoS ONE
Produção Nacional
Revisado por pares
Tárcio Teodoro Braga, Juan Sebastián Henao Agudelo, Niels Olsen Saraiva Câmara,
Macrophages play essential activities in homeostasis maintenance, tissue regeneration and wound healing. However, when the physiological process of wound healing is deregulated by persistent insults and chronic diseases, macrophages can participate actively in the development of fibrosis. In this regard, the exacerbation or resolution of fibrosis depends on the type of macrophages polarized and the severity and duration of the inflammatory insult. M1 macrophages use glycolytic metabolism to optimize ...
Tópico(s): Pressure Ulcer Prevention and Management
2015 - Frontiers Media | Frontiers in Immunology
Ronald J. Parchem, Nicole Moore, Jennifer L. Fish, Jacqueline G. Parchem, Tárcio Teodoro Braga, Archana Shenoy, Michael C. Oldham, John L.R. Rubenstein, Richard A. Schneider, Robert Blelloch,
The evolutionarily conserved miR-302 family of microRNAs is expressed during early mammalian embryonic development. Here, we report that deletion of miR-302a-d in mice results in a fully penetrant late embryonic lethal phenotype. Knockout embryos have an anterior neural tube closure defect associated with a thickened neuroepithelium. The neuroepithelium shows increased progenitor proliferation, decreased cell death, and precocious neuronal differentiation. mRNA profiling at multiple time points ...
Tópico(s): RNA Research and Splicing
2015 - Cell Press | Cell Reports
Produção Nacional
Revisado por pares
Beatriz Silva Ibrahim, Éric Diego Barioni, Cíntia Scucuglia Heluany, Tárcio Teodoro Braga, Carine Cristiane Drewes, Silvia Goes Costa, Niels Olsen Saraiva Câmara, Sandra Helena Poliselli Farsky, Adriana Lino‐dos‐Santos‐Franco,
Inhalation of formaldehyde (FA) during the pregnancy induces oxidative stress in the uterus, and here we hypothesized that this mechanism may be responsible for the impaired immune response detected in the offspring. In order to investigate the protective effects of Vitamin C on the oxidative stress induced by FA in the uterine microenvironment, pregnant Wistar rats were treated with vitamin C (150mg/kg, gavage) or vehicle (distilled water, gavage) 1h before FA exposure (0.92mg/m(3), 1h/day, 5days/week), ...
Tópico(s): Vitamin C and Antioxidants Research
2016 - Elsevier BV | Toxicology and Applied Pharmacology
Robert Schierwagen, Lara Maybüchen, Kanishka Hittatiya, Sabine Klein, Frank Erhard Uschner, Tárcio Teodoro Braga, Bernardo S. Franklin, Georg Nickenig, Christian P. Strassburg, Jogchum Plat, Tilman Sauerbruch, Eicke Latz, Dieter Lütjohann, Sebastian Zimmer, Jonel Trebicka,
Nonalcoholic steatohepatitis (NASH), especially as part of the metabolic syndrome (MS), is an increasing burden in Western countries. Statins are already used in MS and seem to be beneficial in liver diseases. The aim of this study was to investigate the molecular mechanisms underlying pleiotropic effects on small GTPases of statins in NASH. NASH within MS was induced in 12-wk-old apoE-/- mice after 7 wk of Western diet (NASH mice). Small GTPases were inhibited by activated simvastatin (SMV), NSC23766 ( ...
Tópico(s): Lipid metabolism and disorders
2016 - American Physiological Society | AJP Gastrointestinal and Liver Physiology
Produção Nacional
Revisado por pares
Rodrigo Silva Macedo, Mayara Peres Leal, Tárcio Teodoro Braga, Éric Diego Barioni, Stephanie de Oliveira Duro, Anna Carolina Ratto Tempestini Horliana, Niels Olsen Saraiva Câmara, Tânia Marcourakis, Sandra Helena Poliselli Farsky, Adriana Lino‐dos‐Santos‐Franco,
Formaldehyde is ubiquitous pollutant that induces oxidative stress in the lung. Several lung diseases have been associated with oxidative stress and their control is necessary. Photobiomodulation therapy (PBMT) has been highlighted as a promissory treatment, but its mechanisms need to be better investigated. Our objective was to evaluate the effects of PBMT on the oxidative stress generated by FA exposure. Male Wistar rats were submitted to FA exposure of 1% or vehicle (3 days) and treated or not ...
Tópico(s): Laser Applications in Dentistry and Medicine
2016 - Hindawi Publishing Corporation | Mediators of Inflammation
Produção Nacional
Revisado por pares
Thiago Bruder‐Nascimento, Nathanne S. Ferreira, Camila Z. Zanotto, Fernanda Naira Zambelli Ramalho, Isabela O. Pequeno, Vânia C. Olivon, Karla B Neves, Rhéure Alves-Lopes, Eduardo Geraldo de Campos, Carlos Alberto A. Silva, Rubens Fazan, Daniela Carlos, Fabíola Mestriner, Douglas da Silva Prado, Felipe V. Pereira, Tárcio Teodoro Braga, João Paulo Mesquita Luiz, Stêfany B. A. Cau, Paula Condé Lamparelli Elias, Ayrton Custódio Moreira, Niels Olsen Saraiva Câmara, Dario S. Zamboni, José C. Alves‐Filho, Rita C. Tostes,
Inflammation is a key feature of aldosterone-induced vascular damage and dysfunction, but molecular mechanisms by which aldosterone triggers inflammation remain unclear. The NLRP3 inflammasome is a pivotal immune sensor that recognizes endogenous danger signals triggering sterile inflammation.We analyzed vascular function and inflammatory profile of wild-type (WT), NLRP3 knockout (NLRP3-/-), caspase-1 knockout (Casp-1-/-), and interleukin-1 receptor knockout (IL-1R-/-) mice treated with vehicle or aldosterone ( ...
Tópico(s): Sodium Intake and Health
2016 - Lippincott Williams & Wilkins | Circulation
Produção Nacional
Revisado por pares
Maíra Estanislau Soares de Almeida, K. S. Monteiro, Ellen Emi Kato, Sandra Coccuzzo Sampaio, Tárcio Teodoro Braga, Niels Olsen Saraiva Câmara, Marcelo Lazzaron Lamers, Marinilce Fagundes dos Santos,
Tópico(s): Cellular Mechanics and Interactions
2016 - Springer Science+Business Media | Molecular and Cellular Biochemistry
Produção Nacional
Revisado por pares
Tárcio Teodoro Braga, Matheus Corrêa-Costa, Reinaldo Correia Silva, Mário Costa Cruz, Meire Ioshie Hiyane, João S. Silva, Katia R. Perez, Iolanda Midea Cuccovia, Niels Olsen Saraiva Câmara,
Tópico(s): Immune responses and vaccinations
2017 - Springer Nature | Inflammopharmacology
Florian Hoß, Verena Rolfes, Mariana Rodrigues Davanso, Tárcio Teodoro Braga, Bernardo S. Franklin,
Assembly of a relatively large protein aggregate or "speck" formed by the adaptor protein ASC is a common downstream step in the activation of most inflammasomes. This unique feature of ASC allows its visualization by several imaging techniques and constitutes a reliable and feasible readout for inflammasome activation in cells and tissues. We have previously described step-by-step protocols to generate immortalized cell lines stably expressing ASC fused to a fluorescent protein for measuring inflammasome ...
Tópico(s): Heme Oxygenase-1 and Carbon Monoxide
2017 - Springer Science+Business Media | Methods in molecular biology
Produção Nacional
Revisado por pares
Ângela Castoldi, Vinícius Andrade‐Oliveira, Cristhiane Fávero de Aguiar, Mariane Tami Amano, Jennifer Lee, Marcelli Terumi Miyagi, Marcela Teatin Latância, Tárcio Teodoro Braga, Marina Burgos da Silva, Aline Ignácio, Joanna D.C.C. Lima, Flávio V. Loures, José Antônio Tavares de Albuquerque, Marina Barguil Macêdo, Rafael Ribeiro Almeida, Jonas Weissmann Gaiarsa, Luis Alberto Luévano‐Martínez, Thiago Belchior, Meire Ioshie Hiyane, Gordon D. Brown, Marcelo A. Mori, Christian Hoffmann, Marília Seelaender, William T. Festuccia, Pedro M. Moraes‐Vieira, Niels Olsen Saraiva Câmara,
The underlying mechanism by which MyD88 regulates the development of obesity, metainflammation, and insulin resistance (IR) remains unknown. Global deletion of MyD88 in high-fat diet (HFD)-fed mice resulted in increased weight gain, impaired glucose homeostasis, elevated Dectin-1 expression in adipose tissue (AT), and proinflammatory CD11c+ AT macrophages (ATMs). Dectin-1 KO mice were protected from diet-induced obesity (DIO) and IR and had reduced CD11c+ AT macrophages. Dectin-1 antagonist improved ...
Tópico(s): Ginseng Biological Effects and Applications
2017 - Cell Press | Cell Reports
Produção Nacional
Revisado por pares
Juan Sebastián Henao Agudelo, Tárcio Teodoro Braga, Mariane Tami Amano, Marcos Antônio Cenedeze, Regiane Aparecida Cavinato, Amandda R. Peixoto-Santos, Marcelo N. Muscará, Simone A. Teixeira, Mário Costa Cruz, Ângela Castoldi, Rita Sinigaglia‐Coimbra, Álvaro Pacheco‐Silva, Danilo Cândido de Almeida, Niels Olsen Saraiva Câmara,
Mesenchymal stromal cells (MSCs) are multipotent cells with abilities to exert immunosuppressive response promoting tissue repair. Studies have shown that MSCs can secrete extracellular vesicles (MVs-MSCs) with similar regulatory functions to the parental cells. Furthermore, strong evidence suggesting that MVs-MSCs can modulate several immune cells (i.e., Th1, Th17, and Foxp3+ T cells). However, their precise effect on macrophages (Mϕs) remains unexplored. We investigated the immunoregulatory effect ...
Tópico(s): MicroRNA in disease regulation
2017 - Frontiers Media | Frontiers in Immunology
Produção Nacional
Revisado por pares
Eduardo Mendes, Beatriz G. Acetturi, Andrew Maltez Thomas, Flaviano S. Martins, Amanda Rabello Crisma, Gilson Masahiro Murata, Tárcio Teodoro Braga, Niels Olsen Saraiva Câmara, Adriana Lino dos Santos Franco, João Carlos Setúbal, Willian R. Ribeiro, Claudéte J. Valduga, Rui Curi, Emmanuel Dias‐Neto, Wothan Tavares-de-Lima, Caroline M. Ferreira,
Asthma is a chronic inflammatory disease that affects more females than males after puberty, and its symptoms and severity in women change during menstruation and menopause. Recently, evidence has demonstrated that interactions among the microbiota, female sex hormones, and immunity are associated with the development of autoimmune diseases. However, no studies have investigated if therapeutic gut microbiota modulation strategies could affect asthma exacerbation during menstruation and menopause. ...
Tópico(s): Gastrointestinal motility and disorders
2017 - Frontiers Media | Frontiers in Microbiology
Produção Nacional
Revisado por pares
Tárcio Teodoro Braga, Maria Fernanda Forni, Matheus Corrêa-Costa, Rodrigo Nalio Ramos, José Alexandre Marzagão Barbuto, Paola Cristina Branco, Ângela Castoldi, Meire Ioshie Hiyane, Mariana Rodrigues Davanso, Eicke Latz, Bernardo S. Franklin, Alicia J. Kowaltowski, Niels Olsen Saraiva Câmara,
Abstract Uric acid is a damage-associated molecular pattern (DAMP), released from ischemic tissues and dying cells which, when crystalized, is able to activate the NLRP3 inflammasome. Soluble uric acid (sUA) is found in high concentrations in the serum of great apes, and even higher in some diseases, before the appearance of crystals. In the present study, we sought to investigate whether uric acid, in the soluble form, could also activate the NLRP3 inflammasome and induce the production of IL-1β. ...
Tópico(s): Heme Oxygenase-1 and Carbon Monoxide
2017 - Nature Portfolio | Scientific Reports
Produção Nacional
Revisado por pares
Maria Fernanda Forni, Julia Peloggia, Tárcio Teodoro Braga, Jesús Eduardo Ortega Chinchilla, Jorge S. Shinohara, Carlos A. Navas, Niels Olsen Saraiva Câmara, Alicia J. Kowaltowski,
Caloric restriction (CR) is the most effective intervention known to enhance lifespan, but its effect on the skin is poorly understood. Here, we show that CR mice display fur coat remodeling associated with an expansion of the hair follicle stem cell (HFSC) pool. We also find that the dermal adipocyte depot (dWAT) is underdeveloped in CR animals. The dermal/vennule annulus vasculature is enlarged, and a vascular endothelial growth factor (VEGF) switch and metabolic reprogramming in both the dermis and ...
Tópico(s): Thermoregulation and physiological responses
2017 - Cell Press | Cell Reports
Produção Nacional
Revisado por pares
Felipe Grabarz, Cristhiane Fávero de Aguiar, Matheus Corrêa-Costa, Tárcio Teodoro Braga, Meire Ioshie Hyane, Vinícius Andrade‐Oliveira, Maristella A. Landgraf, Niels Olsen Saraiva Câmara,
Tópico(s): IL-33, ST2, and ILC Pathways
2017 - Springer Nature | Inflammopharmacology
Produção Nacional
Felipe V. Pereira, Amanda Campelo Lima de Melo, Jun Siong Low, Iris Castro, Tárcio Teodoro Braga, Danilo Cândido de Almeida, Ana Gabriela U. Batista de Lima, Meire Ioshie Hiyane, Matheus Corrêa-Costa, Vinícius Andrade‐Oliveira, Clarice S. Origassa, Rosana M. Pereira, Susan M. Kaech, Elaine G. Rodrigues, Niels Olsen Saraiva Câmara,
The antitumor effect of metformin has been demonstrated in several types of cancer; however, the mechanisms involved are incompletely understood. In this study, we showed that metformin acts directly on melanoma cells as well as on the tumor microenvironment, particularly in the context of the immune response. In vitro, metformin induces a complex interplay between apoptosis and autophagy in melanoma cells. The anti-metastatic activity of metformin in vivo was assessed in several mouse models challenged ...
Tópico(s): Autophagy in Disease and Therapy
2018 - Impact Journals LLC | Oncotarget
Produção Nacional
Revisado por pares
Laís Cavalieri Paredes, Niels Olsen Saraiva Câmara, Tárcio Teodoro Braga,
In contrast to mammals, lower vertebrates, including zebrafish (Danio rerio), have the ability to regenerate damaged or lost tissues, such as the caudal fin, which makes them an ideal model for tissue and organ regeneration studies. Since several diseases involve the process of transition between fibrosis and tissue regeneration, it is necessary to attain a better understanding of these processes. It is known that the cells of the immune system, especially macrophages, play essential roles in regeneration ...
Tópico(s): Cancer-related gene regulation
2019 - Frontiers Media | Frontiers in Physiology
Produção Nacional
Revisado por pares
Tárcio Teodoro Braga, Wesley Nogueira Brandão, Hátylas Azevedo, Fernanda Fernandes Terra, Amanda Campelo Lima de Melo, Felipe V. Pereira, Vinícius Andrade‐Oliveira, Meire Ioshie Hiyane, Jean Pierre Schatzmann Peron, Niels Olsen Saraiva Câmara,
NLRP3 inflammasome [NLR (nucleotide-binding domain, leucine-rich repeat containing protein) Pyrin-domain-containing 3 ] functions as an innate sensor of several PAMPs and DAMPs (pathogen- and damage-associated molecular patterns). It has been also reported as a transcription factor related to Th2 pattern, although its role in the adaptive immunity has been controversial, mainly because the studies were performed using gene deletion approaches. In the present study, we have investigated the NLRP3 gain- ...
Tópico(s): Immune Response and Inflammation
2019 - Portland Press | Clinical Science
Produção Nacional
Revisado por pares
Raphael José Ferreira Felizardo, Danilo Cândido de Almeida, Rafael Luiz Pereira, Ingrid Kazue Mizuno Watanabe, Nayara T. S. Doimo, Willian R. Ribeiro, Marcos Antônio Cenedeze, Meire Ioshie Hiyane, Mariane Tami Amano, Tárcio Teodoro Braga, Caroline M. Ferreira, Raphael B. Parmigiani, Vinícius Andrade‐Oliveira, Rildo Aparecido Volpini, Marco Aurélio Ramirez Vinolo, Eliana Mariño, R. Robert, Charles R. Mackay, Niels Olsen Saraiva Câmara,
Butyrate is a short‐chain fatty acid derived from the metabolism of indigestible carbohydrates by the gut microbiota. Butyrate contributes to gut homeostasis, but it may also control inflammatory responses and host physiology in other tissues. Butyrate inhibits histone deacetylases, thereby affecting gene transcription, and also signals through the metabolite‐sensing G protein receptor (GPR)109a. We produced an mAb to mouse GPR109a and found high expression on podocytes in the kidney. Wild‐type and ...
Tópico(s): Digestive system and related health
2019 - Wiley | The FASEB Journal