Lenka Zerzánková, Hana Kostrhunová, Marie Vojtı́šková, Olga Nováková, Tereza Suchánková, Miaoxin Lin, Zijian Guo, Jana Kašpárková, Viktor Brabec,
The primary objective was to understand more deeply the molecular mechanism underlying different antitumor effects of dinuclear PtII complexes containing aromatic linkers of different length, {[cis-Pt(NH3)2Cl]2(4,4′-methylenedianiline)}2+ (1) and {[cis-Pt(NH3)2Cl]2(α,α′-diamino-p-xylene)}2+ (2). These complexes belong to a new generation of promising polynuclear platinum drugs resistant to decomposition by sulfur nucleophiles which hampers clinical use of bifunctional polynuclear trans PtII complexes ...
Tópico(s): DNA and Nucleic Acid Chemistry
2010 - Elsevier BV | Biochemical Pharmacology
Michaela Nováková, Tereza Fábryová, Doris Vokurková, Iva Dolečková, Jiřı́ Kopecký, Pavel Hrouzek, Lenka Tůmová, José Cheel,
Global demand for natural pigments has increased in the past few years. Myxoxanthophyll, a glycosylated monocyclic carotenoid, is a pigment that occurs naturally in cyanobacteria but no scalable isolation process has been developed to obtain it from its natural source to date. In this study, myxoxanthophyll was isolated from unicellular cyanobacterium Synechocystis salina (S. salina) using high-performance countercurrent chromatography (HPCCC), where the lower phase of the biphasic solvent system ...
Tópico(s): Fungal Biology and Applications
2020 - Multidisciplinary Digital Publishing Institute | Separations
Tereza Nováková, Tomáš Navrátil, Martin Schütze, Jan Rohovec, Šárka Matoušková, Michal Hošek, Tomáš Matys Grygar,
The Chemical Factory in Marktredwitz (CFM) is known as the oldest chemical factory in Germany (1778-1985), and from the beginning of the 20th century focused primarily on the production of mercury (Hg) compounds. Due to extensive pollution, together with employee health issues, the CFM was shut in 1985 by a government order and remediation works proceeded from 1986 to 1993. In this study, tree ring archives of European Larch (Larix decidua Mill.) were used to reconstruct changes of air Hg levels near ...
Tópico(s): Toxic Organic Pollutants Impact
2022 - Elsevier BV | Environmental Pollution
Peter Huszár, Jan Karlický, Jana Marková, Tereza Nováková, Marina Liaskoni, Lukáš Bartík,
Abstract. Urban areas are hot spots of intense emissions, and they influence air quality not only locally but on a regional or even global scale. The impact of urban emissions over different scales depends on the dilution and chemical transformation of the urban plumes which are governed by the local- and regional-scale meteorological conditions. These are influenced by the presence of urbanized land surface via the so-called urban canopy meteorological forcing (UCMF). In this study, we investigate ...
Tópico(s): Urban Heat Island Mitigation
2021 - Copernicus Publications | Atmospheric chemistry and physics
Tereza Nováková, Tomáš Navrátil, Jason D. Demers, Michal Roll, Jan Rohovec,
Tree ring records are increasingly being used as a geochemical archive of past atmospheric mercury (Hg) pollution. However, it is not clear whether all tree species can be used reliably for this purpose. We compared tree-ring Hg records of two coniferous species - widely used Scots pine (Pinus sylvestris) and less frequently used European larch (Larix decidua) at 6 study sites across the Czech Republic. Site-specific mean Hg concentrations in tree-ring segments of larch ranged from 2.1 to 5.2 μg kg−1, ...
Tópico(s): Lichen and fungal ecology
2020 - Elsevier BV | The Science of The Total Environment
Jan Karlický, Peter Huszár, Tereza Nováková, Michal Belda, Filip Švábik, Jana Ďoubalová, Tomáš Halenka,
Abstract. Cities and urban areas are well-known for their impact on meteorological variables and thereby modification of the local climate. Our study aims to generalize the urban-induced changes in specific meteorological variables by introducing a single phenomenon – the urban meteorology island (UMI). A wide ensemble of 24 model simulations with the Weather Research and Forecasting (WRF) regional climate model and the Regional Climate Model (RegCM) on a European domain with 9 km horizontal resolution ...
Tópico(s): Meteorological Phenomena and Simulations
2020 - Copernicus Publications | Atmospheric chemistry and physics
Peter Huszár, Jan Karlický, Jana Ďoubalová, Tereza Nováková, Kateřina Šindelářová, Filip Švábik, Michal Belda, Tomáš Halenka, Michal Žák,
Abstract. This paper deals with the urban land-surface impact (i.e., the urban canopy meteorological forcing; UCMF) on extreme air pollution for selected central European cities for present-day climate conditions (2015–2016) using three regional climate-chemistry models: the regional climate models RegCM and WRF-Chem (its meteorological part), the chemistry transport model CAMx coupled to either RegCM and WRF and the “chemical” component of WRF-Chem. Most of the studies dealing with the urban canopy ...
Tópico(s): Atmospheric Ozone and Climate
2020 - Copernicus Publications | Atmospheric chemistry and physics
Peter Huszár, Jan Karlický, Jana Ďoubalová, Kateřina Šindelářová, Tereza Nováková, Michal Belda, Tomáš Halenka, Michal Žák, Petr Pišoft,
Abstract. It is well known that the urban canopy (UC) layer, i.e., the layer of air corresponding to the assemblage of the buildings, roads, park, trees and other objects typical to cities, is characterized by specific meteorological conditions at city scales generally differing from those over rural surroundings. We refer to the forcing that acts on the meteorological variables over urbanized areas as the urban canopy meteorological forcing (UCMF). UCMF has multiple aspects, while one of the most ...
Tópico(s): Wind and Air Flow Studies
2020 - Copernicus Publications | Atmospheric chemistry and physics
Tomáš Navrátil, Tereza Nováková, Michal Roll, James B. Shanley, Jiřı́ Kopáček, Jan Rohovec, Jiří Kaňa, Pavel Cudlín,
We evaluated a 14-year trend (2003–2017) in mercury (Hg) concentrations and fluxes in six litterfall categories (needles, bark, twigs, cones, lichen, and a mixture of unidentified fragments) at six research plots situated in two central European unmanaged mountain forest stands, dominated by mature Norway spruce. One of the stands (catchment of Plešné Lake, PL) was infested by bark beetle and all mature spruces died at three of four research plots during the study. One PL plot and two plots in the second ...
Tópico(s): Fire effects on ecosystems
2019 - Elsevier BV | The Science of The Total Environment
Kristýna Kotková, Tereza Nováková, Štěpánka Tůmová, Tímea Kiss, Jan Popelka, Martin Faměra,
Floodplains are one of the most complex sedimentary environments used for the reconstruction of human impacts on fluvial deposition and catchment pollution. Studies of polluted floodplains require an interdisciplinary approach, including tools from geomorphology, geophysics, and geochemistry. The spatial distribution of pollutants can reflect not only pollution history but also post-depositional transfers of pollutants. The Litavka River (SW Czech Republic) was impacted by historical mining and processing ...
Tópico(s): Heavy metals in environment
2018 - Elsevier BV | Geomorphology
Tomáš Navrátil, Tereza Nováková, James B. Shanley, Jan Rohovec, Šárka Matoušková, Maria Vaňková, Stephen A. Norton,
We propose the tree rings of European Larch (Larix decidua) as a widely available and reliable geochemical archive of local and regional changes in atmospheric mercury (Hg). Mean Hg concentrations in larch tree rings from 8 background sites across the Czech Republic ranged from 2.2 to 4.8 μg kg–1; the maximum concentrations occurred in the period 1951–1970. At 3 sites impacted by Hg-emission sources [gold amalgamation processing, caustic soda production, and lead (Pb) ore smelting] mean larch tree ring ...
Tópico(s): Heavy Metal Exposure and Toxicity
2018 - American Chemical Society | Environmental Science & Technology
Lucie Majerová, Ondřej Bábek, Tomáš Navrátil, Tereza Nováková, Jiří Štojdl, Jitka Elznicová, Karel Hron, Tomáš Matys Grygar,
Tópico(s): Water Quality and Pollution Assessment
2018 - Springer Science+Business Media | Environmental Earth Sciences
Alastair J.H. Clement, Tereza Nováková, Karen A. Hudson‐Edwards, Ian C. Fuller, Mark G. Macklin, Elizabeth G. Fox, Ignacio Zapico,
Between 1875 and 1955 approximately 250,000 Mg yr− 1 of mercury-, arsenic-, and cyanide-contaminated mine tailings were discharged directly into the Ohinemuri River and its tributaries, in the Coromandel Region, North Island, New Zealand. A devastating flood on 14 January 1907 deposited large amounts of mine waste across the floodplain of the Ohinemuri and Waihou rivers in the vicinity of the township of Paeroa. The 1907 mine-waste flood deposit was located as a dirty yellow silt in cores and floodplain ...
Tópico(s): Heavy Metal Exposure and Toxicity
2017 - Elsevier BV | Geomorphology
Jan Sedláček, Ondřej Bábek, Tereza Nováková,
Tópico(s): Groundwater and Isotope Geochemistry
2016 - Elsevier BV | The Science of The Total Environment
Tereza Nováková, Kristýna Kotková, Jitka Elznicová, Ladislav Strnad, Zbyněk Engel, Tomáš Matys Grygar,
The fluvial system of the Litavka River in the Czech Republic has been severely polluted by polymetallic ore mining and smelting that occurred mainly between the 1780s and 1970s. To decipher the mechanisms of the pollution transport pathways, we analysed river valley sediments from river headwaters upstream from the ore district through mining and smelting areas to downstream sites. We sampled recently inundated areas as well as sites just outside 100-year (Q100) inundation. In the river valley, ...
Tópico(s): Hydrology and Watershed Management Studies
2015 - Elsevier BV | Journal of Geochemical Exploration
Ondřej Bábek, Tomáš Matys Grygar, Martin Faměra, Karel Hron, Tereza Nováková, Jan Sedláček,
Defining anomalies from geochemical background is a principal step in anthropogenic contamination studies and environmental risk assessment, and yet the complexity of processes affecting the composition of sediments makes this task extremely difficult. We address grain size and sediment provenance as two parameters influencing the geochemistry of contaminated fluvial sediments. We analysed 576 sediment samples from channels, floodplains, oxbow lakes, and dam reservoirs of the Morava River, Czech ...
Tópico(s): Heavy metals in environment
2015 - Elsevier BV | CATENA
Tereza Nováková, Tomáš Matys Grygar, Kristýna Kotková, Jitka Elznicová, Ladislav Strnad, Martin Mihaljevič,
Tópico(s): Geochemistry and Elemental Analysis
2015 - Springer Science+Business Media | Journal of Soils and Sediments
Tomáš Matys Grygar, Tereza Nováková, Ondřej Bábek, Jitka Elznicová, Nikola Vadinova,
Enrichment factors for Cr, Cu, Ni, Pb and Zn in floodplain fines from the middle and the lower courses of the Jizera River (a tributary of the Elbe River in the Czech Republic) were evaluated to compare the original contamination profiles with post-depositional and pedogenic changes. Background concentrations of heavy metals were assessed from uncontaminated sediments (soils) in the study area that belong to the same sedimentary facies and were not affected by reductimorphic processes. Facies assignment ...
Tópico(s): Geology and Paleoclimatology Research
2013 - Elsevier BV | The Science of The Total Environment
Martin Faměra, Ondřej Bábek, Tomáš Matys Grygar, Tereza Nováková,
Tópico(s): Geological Formations and Processes Exploration
2013 - Springer Science+Business Media | Water Air & Soil Pollution
Tereza Nováková, Tomáš Matys Grygar, Ondřej Bábek, Martin Faměra, Martin Mihaljevič, Ladislav Strnad,
Tópico(s): Geology and Paleoclimatology Research
2012 - Springer Science+Business Media | Journal of Soils and Sediments
Tomáš Matys Grygar, Tereza Nováková, Martin Mihaljevič, Ladislav Strnad, Ivo Světlík, Leona Koptíková, Lenka Lisá, Rudolf Brázdil, Zdeněk Máčka, Zdeněk Stachoň, Hélèna Svobodova, David Wray,
Sediment profiles from the floodplain of Morava River in the Czech Republic have been collected from exposed river banks (4–6 m long sections) and cores (2–4 m deep) and investigated using a set of geochemical proxies validated by granulometry and conventional geochemical analysis, outlined in our previous paper. The work was conducted to evaluate the increase in sedimentation rate during Medieval and modern time periods. Correlation of sediments along the current channel belt allows identification ...
Tópico(s): Soil erosion and sediment transport
2011 - Elsevier BV | CATENA
Tomáš Matys Grygar, Jan Sedláček, Ondřej Bábek, Tereza Nováková, Ladislav Strnad, Martin Mihaljevič,
Tópico(s): Geochemistry and Geologic Mapping
2011 - Springer Science+Business Media | Water Air & Soil Pollution
Tomáš Matys Grygar, Ivo Světlík, Lenka Lisá, Leona Koptíková, Aleš Bajer, David Wray, Vojtěch Ettler, Martin Mihaljevič, Tereza Nováková, Magdaléna Koubová, Jan Novák, Zdeněk Máčka, Mirek Smetana,
The floodplain of the Morava River in Strážnické Pomoraví, south-east Moravia, Czech Republic contains a very valuable record of regional environmental change, which goes back to several thousand years. Its interpretation has been limited by poor stratigraphic correlation and dating of the sediments. We present a geochemical solution to this challenge. We studied 8 outcrops of floodplain deposits from 4 localities along a 6 km long part of the current meander belt of the Morava River in Strážnické ...
Tópico(s): Archaeology and ancient environmental studies
2009 - Elsevier BV | CATENA
Tomáš Halenka, Michal Belda, Peter Huszár, Jan Karlický, Tereza Nováková, Michal Žák,
To assess the impact of cities on climate, modelling is used with inclusion of urban parameterisation which is important when applying higher resolution. It is essential to assess uncertainties of urban effect parameterisations. To estimate this we performed experiments with available settings of urban canopy models over central Europe for 2001-2010. We have used RegCM4 and WRF in 10 km resolution, three surface schemes and five urban canopy parameterisations available. Selected WRF options were ...
Tópico(s): Remote Sensing in Agriculture
2019 - Inderscience Publishers | International Journal of Environment and Pollution
Tomáš Navrátil, James B. Shanley, Jan Rohovec, Irena Dobešová, Šárka Matoušková, Michal Roll, Tereza Nováková, Filip Oulehle,
Abstract From 2011 to 2019, mercury (Hg) stores and fluxes were studied in the small forested catchment Lesní potok (LES) in the central Czech Republic using the watershed mass balance approach together with internal measurements. Mean input fluxes of Hg via open bulk deposition, beech throughfall and spruce throughfall during the periodwere 2.9, 3.9 and 7.6 μg m −2 year −1 , respectively. These values were considerably lower than corresponding deposition Hg fluxes reported in the early years of the 21st ...
Tópico(s): Heavy metals in environment
2021 - Wiley | Hydrological Processes
Tereza Nováková, Táňa Macháčková, Ján Novák, Petr Hude, Július Godava, Víta Žampachová, Jan Oppelt, Filip Zlámal, Petr Němec, Helena Bedáňová, Ondřej Slabý, Julie Bienertová Vašků, Lenka Špinarová, Jan Krejčí,
Introduction: Acute cellular rejection (ACR) of heart allografts represents the most common reason for graft failure. Endomyocardial biopsies (EMB) are still subject to substantial interobserver variability. Novel biomarkers enabling precise ACR diagnostics may decrease interobserver variability. We aimed to identify a specific subset of microRNAs reflecting the presence of ACR. Patients and Methods: Monocentric retrospective study. A total of 38 patients with the anamnesis of ACR were identified ...
Tópico(s): MicroRNA in disease regulation
2019 - Multidisciplinary Digital Publishing Institute | Cells
Tomáš Navrátil, Tereza Nováková, James B. Shanley, Jan Rohovec, Maria Vaňková,
The fate of atmospherically deposited mercury (Hg) was studied in forest soils situated near various Hg anthropogenic emission sources, including chlor-alkali plants, cement production, and pig iron and steel factories in the Czech Republic. Some of these emission sources were more active in the past, while others continue operation with lowered dust and Hg emissions up to the present day. The impact of Hg emission sources on forest soil was assessed with respect to other soil parameters, including ...
Tópico(s): Heavy Metal Exposure and Toxicity
2021 - Elsevier BV | Journal of Geochemical Exploration
Tomáš Navrátil, Douglas A. Burns, Tereza Nováková, Jiří Kaňa, Jan Rohovec, Michal Roll, Vojtěch Ettler,
Archived soil samples can provide important information on the history of environmental contamination and by comparison with recently collected samples, temporal trends can be inferred. Little previous work has addressed whether mercury (Hg) concentrations in soil samples are stable with long-term storage under standard laboratory conditions. In this study, we have re-analyzed using cold vapor atomic absorption spectroscopy a set of archived soil samples that ranged from relatively pristine mountainous ...
Tópico(s): Analytical chemistry methods development
2018 - Elsevier BV | Chemosphere
Veronika Novakova, Petr Hladík, Tereza Filandrová, Ivana Zajícová, Veronika Krepsová, Miroslav Miletín, Juraj Lenčo, Petr Zimčík,
A series of unsymmetrical tetrapyrazinoporphyrazines (TPyzPzs) from the group of azaphthalocyanines with one peripherally attached amino substituent (donor) were synthesized, and their photophysical properties (fluorescence quantum yield and singlet oxygen quantum yield) were determined. The synthesized TPyzPzs were expected to undergo intramolecular charge transfer (ICT) as the main pathway for deactivating their excited states. Several structural factors were found to play a critical role in ICT efficiency. ...
Tópico(s): Photochemistry and Electron Transfer Studies
2014 - Royal Society of Chemistry | Physical Chemistry Chemical Physics
Veronika Novakova, Miroslav Miletín, Tereza Filandrová, Juraj Lenčo, Aleš Růžička, Petr Zimčík,
Conditions for the Newman-Kwart rearrangement of phenols into thiophenols were investigated in relation to the bulkiness of substituents at the 2 and 6 positions of the starting phenol derivative with an emphasis on eliminating side reactions. Thiophenols with different 2,6-disubstitution patterns (including hydrogen, methyl, isopropyl or tert-butyl groups) were used for the synthesis of 5,6-bis(arylsulfanyl)pyrazine-2,3-dicarbonitriles that underwent cyclotetramerization leading to the corresponding ...
Tópico(s): Oxidative Organic Chemistry Reactions
2014 - American Chemical Society | The Journal of Organic Chemistry