Joe Conner, H. S. Marsden, J. Barklie Clements,
... reductase by a nonapeptide derived from the carboxy-terminus of subunit 2. Nature (London), 321, 441– 443. 79 Paradis, H., Gaudreau, P., Brazeau, P. and Langelier, Y. (1988). Mechanism of inhibition of herpes simplex virus (HSV) ribonucleotide reductase by a nonapeptide corresponding to the carboxy-terminus of its subunit 2. J. Biol. Chem., 263, ... directed mutagenesis and deletion of the car- boxyl terminus of Escherichia coli ribonucleotide reductase protein R2. Effects on catalytic activity and subunit interaction. Biochemistry, 31, 4801– 4807. 86 Telford, E., Lankinen, H. and Marsden, H. (1990). Inhibition of equine herpesvirus type 1 type I- induced ribonucleotide reductase by the nonapeptide YAGAVVNDL. J. Gen. Virol., 71, 1373– 1378. 87 Cohen E. A., Paradis, H., Gaudreau, P., Brazeau, P. and Langelier, Y. ( ...
Tópico(s): Viral-associated cancers and disorders
1994 - Wiley | Reviews in Medical Virology
Tópico(s): Diverse academic and cultural studies
1999 - Italian Federation of Film Societies | Cineforum
Kazuhiro Takahashi, Noriko Makita, Katsunori Manaka, Masataka Hisano, Yuko Akioka, Kenichiro Miura, Noriyuki Takubo, Atsuko Iida, Norishi Ueda, Makiko Hashimoto, Toshiro Fujita, Takashi Igarashi, Takashi Sekine, Taroh Iiri,
... deletion at the 333 position of the C terminus of the V2R. The other is a previously reported mutation Y128S (21Bichet D.G. Arthus M.F. Lonergan M. Hendy G.N. Paradis A.J. Fujiwara T.M. Morgan K. Gregory ...
Tópico(s): Neuroendocrine regulation and behavior
2011 - Elsevier BV | Journal of Biological Chemistry
Hélène Paradis, Pierrette Gaudreau, Paul Brazeau, Yves Langelier,
Abstract Herpes simplex virus (HSV) ribonucleotide reductase activity is specifically inhibited by a synthetic peptide, Tyr-Ala-Gly-Ala-Val-Val-Asn-Asp-Leu (HSV H2-(7-15], corresponding to the carboxyl terminus of its subunit 2 (H2). In order to elucidate the mechanism of action of the nonapeptide a photoreactive analog, [4'-azido-Phe6]HSV H2-(6-15), was synthesized. The photoaffinity probe inhibits HSV ribonucleotide reductase activity, and when radioiodinated, it specifically labeled three viral proteins ...
Tópico(s): Monoclonal and Polyclonal Antibodies Research
1988 - Elsevier BV | Journal of Biological Chemistry
Xudong Huang, Craig Atwood, Robert D. Moir, Mariana A. Hartshorn, Jean‐Paul Vonsattel, Rudolph E. Tanzi, Ashley I. Bush,
... stoichiometry (16Bush A.I. Pettingell Jr., W.H. Paradis M. Tanzi R.E. J. Biol. Chem. 1994; ... attack (16Bush A.I. Pettingell Jr., W.H. Paradis M. Tanzi R.E. J. Biol. Chem. 1994; ... A.I. Pettingell Jr., W.H. Multhaup G. Paradis M.D. Vonsattel J.-P. Gusella J.F. ... A.I. Pettingell Jr., W.H. Multhaup G. Paradis M.D. Vonsattel J.-P. Gusella J.F. ... A.I. Pettingell Jr., W.H. Multhaup G. Paradis M.D. Vonsattel J.-P. Gusella J.F. ... reports (16Bush A.I. Pettingell Jr., W.H. Paradis M. Tanzi R.E. J. Biol. Chem. 1994; ... A.I. Pettingell Jr., W.H. Multhaup G. Paradis M.D. Vonsattel J.-P. Gusella J.F. ...
Tópico(s): Drug Transport and Resistance Mechanisms
1997 - Elsevier BV | Journal of Biological Chemistry
Zhenyu Yang, James Whelan, Robert Babb, Benjamin R. Bowen,
... regulate the activity of DAF-16 (15Ogg S. Paradis S. Gottlieb S. Patterson G.I. Lee L. ... 946Crossref PubMed Scopus (1742) Google Scholar, 15Ogg S. Paradis S. Gottlieb S. Patterson G.I. Lee L. ... identities) and AFX proteins (64% identities) (15Ogg S. Paradis S. Gottlieb S. Patterson G.I. Lee L. ... 2498Crossref PubMed Scopus (558) Google Scholar, 15Ogg S. Paradis S. Gottlieb S. Patterson G.I. Lee L. ... predicted amino acid sequence of the protein N terminus as the initiation codon is shifted upstream (Fig. ...
Tópico(s): Pancreatic function and diabetes
2002 - Elsevier BV | Journal of Biological Chemistry
Steves Morin, Gina Pozzulo, Lynda Robitaille, James C. Cross, Mona Nemer,
... well Primaria plates as described previously (27Charron F. Paradis P. Bronchain O. Nemer G. Nemer M. Mol. ... 2055Crossref PubMed Scopus (277) Google Scholar, 29Morin S. Paradis P. Aries A. Nemer M. Mol. Cell. Biol. ... of the native –700 bp promoter (27Charron F. Paradis P. Bronchain O. Nemer G. Nemer M. Mol. ...
Tópico(s): Congenital Heart Disease Studies
2005 - Elsevier BV | Journal of Biological Chemistry
... over GATA-6 in cardiac myocytes (22Charron F. Paradis P. Bronchain O. Nemer G. Nemer M. Mol. ... myocytes and form stable dimeric complexes (22Charron F. Paradis P. Bronchain O. Nemer G. Nemer M. Mol. ... myocytes suggesting heterodimerization between GATA factors (22Charron F. Paradis P. Bronchain O. Nemer G. Nemer M. Mol. ...
Tópico(s): RNA modifications and cancer
2000 - Elsevier BV | Journal of Biological Chemistry
Séverine Zirah, Sergey A. Kozin, Alexey K. Mazur, Alain Blond, M. Cheminant, Isabelle Ségalas-Milazzo, Pascale Debey, Sylvie Rebuffat,
... A.I. Pettingell W.H. Multhaup G. de Paradis M. Vonsattel J.P. Gusella J.F. Beyreuther ... 30Bush A.I. Pettingell Jr., W.H. de Paradis M. Tanzi R.E. Wasco W. J. Biol. ... Glu15-Lys-NH2) was acetylated at the N terminus and amidated at the C terminus; Aβ-(1-16)hemi was nonacetylated at the N terminus and amidated at the C terminus; Aβ-(1-16)-l-iso-Asp7 was acetylated at the N terminus and amidated at the C terminus and contained one l-iso-Asp residue at ...
Tópico(s): Trace Elements in Health
2005 - Elsevier BV | Journal of Biological Chemistry
Suparna Bhalla, Lynda Robitaille, Mona Nemer,
... 5696Crossref PubMed Scopus (537) Google Scholar, 36Charron F. Paradis P. Bronchain O. Nemer G. Nemer M. Mol. ... 2055Crossref PubMed Scopus (274) Google Scholar, 63Morin, S., Paradis, P., Aries, A., and Nemer, M. (2001) Mol. ...
Tópico(s): Cardiac Fibrosis and Remodeling
2001 - Elsevier BV | Journal of Biological Chemistry
... 210) Google Scholar, 165Wasco W. Gurubhagavatula S. d Paradis M. Romano D.M. Sisodia S.S. Hyman ... A.I. Pettingell W.H. Multhaup G. d Paradis M. Vonsattel J.-P. Gusella J.F. Beyreuther ...
Tópico(s): Tryptophan and brain disorders
1996 - Cell Press | Neuron
M.R. Sandhya Rani, Maria Cristina Gauzzi, Sandra Pellegrini, Eleanor N. Fish, Tao Wei, Richard M. Ransohoff,
... and colleagues (17Cole K.E. Strick C.A. Paradis T.J. Ogborne K.T. Loetscher M. Gladue ... T-lymphocytes (17Cole K.E. Strick C.A. Paradis T.J. Ogborne K.T. Loetscher M. Gladue ... similarity with other JAKs extend to the N terminus of the protein and are designated JAK homology ... a 100-bp probe to the extreme N terminus of the cDNA. The DNA from one clone ...
Tópico(s): Immune Cell Function and Interaction
1999 - Elsevier BV | Journal of Biological Chemistry
Gopal Thinakaran, Hilda H. Slunt, Sangram S. Sisodia,
... Scopus (165) Google Scholar, 14Wasco W. Gurubhagavatula S. Paradis M.D. Romano D.M. Sisodia S.S. ... Scopus (165) Google Scholar, 14Wasco W. Gurubhagavatula S. Paradis M.D. Romano D.M. Sisodia S.S. ...
Tópico(s): Connective tissue disorders research
1995 - Elsevier BV | Journal of Biological Chemistry
Hidenori Taru, Toshiharu Suzuki,
... PDF PubMed Google Scholar, 4Wasco W. Gurubhagavatula S. Paradis M.D. Romano D.M. Sisodia S.S. ... the APLP2 763 isoform) (4Wasco W. Gurubhagavatula S. Paradis M.D. Romano D.M. Sisodia S.S. ... FLAG and HA sequences, respectively, into the amino terminus of the full-length X11L cDNA (22Tomita S. ...
Tópico(s): Prion Diseases and Protein Misfolding
2004 - Elsevier BV | Journal of Biological Chemistry
Timothy L. Reudelhuber, Kenneth E. Bernstein, Patrice Delafontaine,
... fold increase in Ang II receptor the heart, Paradis et al41 reported ventricular hypertrophy that developed only ... most of these studies, in the study by Paradis et al,41 the mice can tolerate several ...
Tópico(s): Blood Pressure and Hypertension Studies
2007 - Lippincott Williams & Wilkins | Hypertension
Frank M. J. Jacobs, Lars P. van der Heide, Patrick J. Wijchers, J. Peter H. Burbach, Marco F.M. Hoekman, Marten P. Smidt,
... in controlling longevity and dauer formation (2Ogg S. Paradis S. Gottlieb S. Patterson G.I. Lee L. ... Scopus (550) Google Scholar) or t (2Ogg S. Paradis S. Gottlieb S. Patterson G.I. Lee L. ... Thr motif is found in the far C terminus of FoxO6, in a region that shows no ...
Tópico(s): Circular RNAs in diseases
2003 - Elsevier BV | Journal of Biological Chemistry
Christopher D. Syme, Rebecca C. Nadal, Stephen E. J. Rigby, John H. Viles,
... 9Bush A.I. Pettingell W.H. Multhaup G. Paradis M.D. Vonsattel J.P. Gusella J.F. ... ms, respectively. Design of Peptides—Typically, the N terminus was left as the native amino group, whereas the truncated C terminus was blocked as the ethyl ester at the C terminus. Peptides synthesized of the human sequence are shown ... 28). The additional 12 residues to the C terminus have no effect on the copper-induced conformational ...
Tópico(s): Drug Transport and Resistance Mechanisms
2004 - Elsevier BV | Journal of Biological Chemistry
Michael J. Schmeißer, Andreas M. Grabrucker, Juergen Bockmann, Tobias M. Boeckers,
... Kim T.K. Greer P.L. Lin Y. Paradis S. Griffith E.C. Hu L.S. Chen ... the full-length protein; Novus), β-catenin (C terminus; Fitzgerald), N terminus (Upstate Biotechnology), SPAR1 (Santa Cruz), LRP (lipoprotein receptor- ... LAPSER1, ProSAP2/Shank3, SPAR1, and β-catenin (N terminus). The crude membrane fraction (P2) of an adult ... a truncated 1form of LAPSER1 without the C terminus (GFP-LAPSER1-ΔC) were cloned into the GFP ... into the pAS2–1 vector. Moreover, the C terminus of SPAR1 was separated into three consecutive prey ...
Tópico(s): Genetics and Neurodevelopmental Disorders
2009 - Elsevier BV | Journal of Biological Chemistry
Christopher W. Marlor, Katherine Delaria, Gary L. Davis, Daniel K. Muller, Jeffrey M. Greve, Paul P. Tamburini,
... such as APLP2 (16Wasco W. Gurubhagavatula S. d. Paradis M. Romano D.M. Sisodia S.S. Hyman ... to the second cysteine residue from the NH2 terminus strongly influences the protease specificity of Kunitz domains ( ... from human placenta which possessed the same NH2 terminus as predicted from the placental bikunin cDNA. The ...
Tópico(s): Protease and Inhibitor Mechanisms
1997 - Elsevier BV | Journal of Biological Chemistry
Gabriele Campanella, Elizabeth M.J. Lee, Jieti Sun, Andrew D. Luster,
... Google Scholar, 24Cole K.E. Strick C.A. Paradis T.J. Ogborne K.T. Loetscher M. Gladue ... of 16 mutants, including residues at the N terminus, identified for a number of chemokines to be ... a set of basic residues at the C terminus, where the GAG binding site of IL-8 ... of the four basic residues of the C terminus decreased the receptor binding 80-fold, and combination ...
Tópico(s): Immune Response and Inflammation
2003 - Elsevier BV | Journal of Biological Chemistry
Wayne I. L. Davies, Jamie I. Vandenberg, Rana Sayeed, A. E. O. Trezise,
... an increased risk of ventricular arrhythmia (32Cheron G. Paradis K. Steru D. Demay G. Lenoir G. Acta ... in a CFTR polypeptide with a distinct amino terminus. Modulation in the levels of these cardiac-specific ...
Tópico(s): RNA and protein synthesis mechanisms
2004 - Elsevier BV | Journal of Biological Chemistry
Simone Eggert, Krzysztof Paliga, Peter Soba, Geneviève Evin, Colin L. Masters, Andreas Weidemann, Konrad Beyreuther,
... Scholar) and APLP-2 (5Wasco W. Gurubhagavatula S. Paradis M.D. Romano D.M. Sisodia S.S. ... by β-secretase, which releases the Aβ N terminus, and by γ-secretase(s), which cleaves in ... cysteine. An antibody recognizing the APLP-2 C terminus was purchased from Calbiochem (residues 752–763). The polyclonal antibody CT13 against the APP C terminus was raised against a synthetic peptide comprising the ...
Tópico(s): Amyloidosis: Diagnosis, Treatment, Outcomes
2004 - Elsevier BV | Journal of Biological Chemistry
Yongheng Cao, Yuji Kamioka, Norihide Yokoi, Toshiyuki Kobayashi, Okio Hino, Masafumi Onodera, Naoki Mochizuki, Jun Nakae,
... 2/AGE-1/AKT signaling pathway (1Ogg S. Paradis S. Gottlieb S. Patterson G.I. Lee L. ... acids and a transactivation domain in the C terminus. FoxOs bind to consensus FoxO-binding sites (GTAAA( ...
Tópico(s): Hippo pathway signaling and YAP/TAZ
2006 - Elsevier BV | Journal of Biological Chemistry
Meir H. Scheinfeld, Enrico Ghersi, Karen Laky, B. J. Fowlkes, Luciano D'adamio,
... Scopus (49) Google Scholar, 3Wasco W. Gurubhagavatula S. Paradis M., D. Romano D.M. Sisodia S.S. ... the γ-secretase cleavage site to the carboxyl terminus of APP, is also produced following γ-secretase ...
Tópico(s): Prion Diseases and Protein Misfolding
2002 - Elsevier BV | Journal of Biological Chemistry
Joanna L. Jankowsky, Linda H. Younkin, Victoria Gonzales, Daniel J. Fadale, Hilda H. Slunt, Henry A. Lester, Steven G. Younkin, David Borchelt,
... A.I. Pettingell W.H. Multhaup G. d Paradis M. Vonsattel J.P Gusella J.F Beyreuther ... Scholar). BACE1 is responsible for releasing the N terminus of Aβ from APP at either of two ... CA) 1:2000; 22C11 mouse anti-APP N terminus monoclonal, kind gift of Drs. Konrad Beyreuther and ...
Tópico(s): Computational Drug Discovery Methods
2007 - Elsevier BV | Journal of Biological Chemistry
... 11873.CrossrefMedlineGoogle Scholar23 van Kats JP, Methot D, Paradis P, Silversides DW, Reudelhuber TL. Use of a ...
Tópico(s): Apelin-related biomedical research
2006 - Lippincott Williams & Wilkins | Hypertension
Saulius Butenas, Thomas Orfeo, Michael Kalafatis, Kenneth G. Mann,
... Scholar 17 Butenas S, Brummel KE, Branda RF, Paradis SG, Mann KG. Mechanism of factor VIIa-dependent ...
Tópico(s): Coagulation, Bradykinin, Polyphosphates, and Angioedema
2006 - Elsevier BV | Journal of Thrombosis and Haemostasis
Ernesto L. Schiffrin, Rhian M. Touyz,
... Online publication date: 1-Apr-2009. Marchesi C, Paradis P and Schiffrin E (2008) Role of the ...
Tópico(s): Neutrophil, Myeloperoxidase and Oxidative Mechanisms
2003 - Lippincott Williams & Wilkins | Arteriosclerosis Thrombosis and Vascular Biology
Tracy Tzu-Ling Tang, Laurence A. Lasky,
... type transcription factors that includes FOXO4 (3Ogg S. Paradis S. Gottlieb S. Patterson G.I. Lee L. ... contained a FLAG epitope tag at its amino terminus and the green fluorescent protein (GFP) at its carboxyl terminus. LY294002 treatment indicated that this inducible FOXO4 stable ...
Tópico(s): Cancer, Hypoxia, and Metabolism
2003 - Elsevier BV | Journal of Biological Chemistry
Leandro Royer, Josiah J. Herzog, Katelyn Kenny, Boriana Tzvetkova, Jesse C. Cochrane, Michael T. Marr, Suzanne Paradis,
... key amino acid residues in the Rem2 N terminus (Arg-79 and Arg-80) completely abolishes its ... key amino acid residues in the Rem2 N terminus (Arg-79 and Arg-80) completely abolishes its ...
Tópico(s): Neuroscience and Neuropharmacology Research
2018 - Elsevier BV | Journal of Biological Chemistry