... dados também fornece informações sobre dados estruturais de elementos puros, minerais, metais e compostos intermetálicos; descritores estruturais (símbolo de Pearson, fórmula ANX, sequências de Wyckoff); dados bibliográficos e resumos; e palavras-chave em métodos, propriedades e aplicações. Atualmente, o Portal de Periódicos assina o conteúdo das Bases de Estruturas Cristalinas (BDEC) para mais de 100 instituições. O conteúdo atende as seguintes grandes áreas da tabela CAPES: Ciências Exatas e da Terra, Engenharias, Ciências Biológicas e Multidisciplinar.
Base de Estruturas Cristalinas (BDEC)
Produção Nacional
Carlos Augusto Sommer, Evandro Fernandes de Lima, Lauro Valentim Stoll Nardi,
... e magnetita. O padrao mostrado pelo diagrama de elementos terra rara, bem como a utilizacao de diagramas discriminantes ...
Tópico(s): Geochemistry and Geologic Mapping
1999 - Sociedade Brasileira de Geologia | Brazilian Journal of Geology
... livros, muitas de suas publicações são aprimoradas com elementos interativos fornecidos por autores, como áudio, vídeo, gráficos, ... da Saúde, Ciências Agrárias, Ciências Exatas e da Terra, Engenharias, Ciências Sociais Aplicadas, Ciências Humanas e Letras ...
Elsevier
... ar, a imaginação dinâmica (das forças) configurada pelo elemento terra e a imagem-lembrança e a imaginação arquetipal, ambas, arregimentadas pelo elemento fogo. Por fim , pode-se concluir que a ...
Tópico(s): French Literature and Critical Theory
2008 - | EDUCAÇÃO E FILOSOFIA
Produção Nacional
Revisado por pares
Giuliano Derrosso, Elisa Yoshie Ichikawa,
... ser deslocados para um local que lhes possibilitasse elementos positivos de terra e trabalho, o que fez com que acabassem ...
Tópico(s): Rural and Ethnic Education
2014 - Associação Nacional de Pós-Graduação e Pesquisa em Ambiente e Sociedade (ANPPAS) | Ambiente & sociedade
Junbum Kim, Samir Rustam, Juan Miguel Mosquera, Scott H. Randell, Renat Shaykhiev, André F. Rendeiro, Olivier Elemento,
Multiplexed imaging and spatial transcriptomics enable highly resolved spatial characterization of cellular phenotypes, but still largely depend on laborious manual annotation to understand higher-order patterns of tissue organization. As a result, higher-order patterns of tissue organization are poorly understood and not systematically connected to disease pathology or clinical outcomes. To address this gap, we developed an approach called UTAG to identify and quantify microanatomical tissue structures ...
Tópico(s): AI in cancer detection
2022 - Nature Portfolio | Nature Methods
Zhuoran Xu, Akanksha Verma, Uska Naveed, Samuel F. Bakhoum, Pegah Khosravi, Olivier Elemento,
Chromosomal instability (CIN) is a hallmark of human cancer yet not readily testable for patients with cancer in routine clinical setting. In this study, we sought to explore whether CIN status can be predicted using ubiquitously available hematoxylin and eosin histology through a deep learning-based model. When applied to a cohort of 1,010 patients with breast cancer (Training set: n = 858, Test set: n = 152) from The Cancer Genome Atlas where 485 patients have high CIN status, our model accurately classified ...
Tópico(s): Genetic factors in colorectal cancer
2021 - Cell Press | iScience
Bhavneet Bhinder, Coryandar Gilvary, Neel S. Madhukar, Olivier Elemento,
Artificial intelligence (AI) is rapidly reshaping cancer research and personalized clinical care. Availability of high-dimensionality datasets coupled with advances in high-performance computing, as well as innovative deep learning architectures, has led to an explosion of AI use in various aspects of oncology research. These applications range from detection and classification of cancer, to molecular characterization of tumors and their microenvironment, to drug discovery and repurposing, to predicting ...
Tópico(s): Cancer Genomics and Diagnostics
2021 - American Association for Cancer Research | Cancer Discovery
Jamal Elkhader, Olivier Elemento,
In the past few years, Artificial Intelligence (AI) techniques have been applied to almost every facet of oncology, from basic research to drug development and clinical care. In the clinical arena where AI has perhaps received the most attention, AI is showing promise in enhancing and automating image-based diagnostic approaches in fields such as radiology and pathology. Robust AI applications, which retain high performance and reproducibility over multiple datasets, extend from predicting indications ...
Tópico(s): Artificial Intelligence in Healthcare and Education
2021 - Elsevier BV | Seminars in Cancer Biology
Precision medicine can be defined as personalized medicine enhanced by technology. In the past, medicine has, in some cases, been personalized. For example, some drugs are dosed on an individualized basis based on age, body-mass index, comorbidities and other clinical parameters. However, overall, medicine has largely followed the ‘one-size-fits-all' paradigm as exemplified in the treatment of essential hypertension or type 2 diabetes mellitus. What has changed in the past few years is that technologies ...
Tópico(s): Health, Environment, Cognitive Aging
2020 - Portland Press | Emerging Topics in Life Sciences
Ariel Oliveira Leite de Souza,
... maternidade é explorada a partir dos arquétipos dos elementos materiais: fogo, água, ar e terra, conforme estabelecido por Gaston Bachelard. Além disso, tendo ...
Tópico(s): Literature, Culture, and Criticism
2020 - UNIVERSIDADE FEDERAL DE UBERLÂNDIA | Téssera
Coryandar Gilvary, Jamal Elkhader, Neel S. Madhukar, Claire Henchcliffe, Marcus D. Goncalves, Olivier Elemento,
Drug repurposing, identifying novel indications for drugs, bypasses common drug development pitfalls to ultimately deliver therapies to patients faster. However, most repurposing discoveries have been led by anecdotal observations (e.g. Viagra) or experimental-based repurposing screens, which are costly, time-consuming, and imprecise. Recently, more systematic computational approaches have been proposed, however these rely on utilizing the information from the diseases a drug is already approved ...
Tópico(s): Cholinesterase and Neurodegenerative Diseases
2020 - Public Library of Science | PLoS Computational Biology
Iman Hajirasouliha, Olivier Elemento,
Traditionally, new treatments have been developed for the population at large. Recently, large-scale genomic sequencing analyses have revealed tremendous genetic diversity between individuals. In diseases driven by genetic events such as cancer, genomic sequencing can unravel all the mutations that drive individual tumors. The ability to capture the genetic makeup of individual patients has led to the concept of precision medicine, a modern, technology-driven form of personalized medicine. Precision ...
Tópico(s): AI in cancer detection
2020 - Elsevier BV | Fertility and Sterility
Neel S. Madhukar, Prashant K. Khade, Linda Huang, Kaitlyn Gayvert, Giuseppe Galletti, Martin Stogniew, Joshua E. Allen, Paraskevi Giannakakou, Olivier Elemento,
Drug target identification is a crucial step in development, yet is also among the most complex. To address this, we develop BANDIT, a Bayesian machine-learning approach that integrates multiple data types to predict drug binding targets. Integrating public data, BANDIT benchmarked a ~90% accuracy on 2000+ small molecules. Applied to 14,000+ compounds without known targets, BANDIT generated ~4,000 previously unknown molecule-target predictions. From this set we validate 14 novel microtubule inhibitors, ...
Tópico(s): Protein Structure and Dynamics
2019 - Nature Portfolio | Nature Communications
Neel S. Madhukar, Olivier Elemento,
Fulfilling the promises of precision medicine will depend on our ability to create patient-specific treatment regimens. Therefore, being able to translate genomic sequencing into predicting how a patient will respond to a given drug is critical. In this chapter, we review common bioinformatics approaches that aim to use sequencing data to predict sample-specific drug susceptibility. First, we explain the importance of customized drug regimens to the future of medical care. Second, we discuss the ...
Tópico(s): vaccines and immunoinformatics approaches
2018 - Springer Science+Business Media | Methods in molecular biology
Kaitlyn Gayvert, Omar M. Aly, James T. Platt, Marcus Bosenberg, David F. Stern, Olivier Elemento,
A promising alternative to address the problem of acquired drug resistance is to rely on combination therapies. Identification of the right combinations is often accomplished through trial and error, a labor and resource intensive process whose scale quickly escalates as more drugs can be combined. To address this problem, we present a broad computational approach for predicting synergistic combinations using easily obtainable single drug efficacy, no detailed mechanistic understanding of drug function, ...
Tópico(s): Bioinformatics and Genomic Networks
2017 - Public Library of Science | PLoS Computational Biology
Kaitlyn Gayvert, Neel S. Madhukar, Olivier Elemento,
Over the past decade, the rate of drug attrition due to clinical trial failures has risen substantially. Unfortunately it is difficult to identify compounds that have unfavorable toxicity properties before conducting clinical trials. Inspired by the effective use of sabermetrics in predicting successful baseball players, we sought to use a similar "moneyball" approach that analyzes overlooked features to predict clinical toxicity. We introduce a new data-driven approach (PrOCTOR) that directly predicts ...
Tópico(s): Pharmacogenetics and Drug Metabolism
2016 - Elsevier BV | Cell chemical biology
Kaitlyn Gayvert, Étienne Dardenne, Cynthia Cheung, Mary Regina Boland, Tal Lorberbaum, Jackline Wanjala, Yu Chen, Mark A. Rubin, Nicholas P. Tatonetti, David S. Rickman, Olivier Elemento,
Mutations in transcription factor (TF) genes are frequently observed in tumors, often leading to aberrant transcriptional activity. Unfortunately, TFs are often considered undruggable due to the absence of targetable enzymatic activity. To address this problem, we developed CRAFTT, a computational drug-repositioning approach for targeting TF activity. CRAFTT combines ChIP-seq with drug-induced expression profiling to identify small molecules that can specifically perturb TF activity. Application ...
Tópico(s): Ubiquitin and proteasome pathways
2016 - Cell Press | Cell Reports
The transformation of normal cells into cancer cells and maintenance of the malignant state and phenotypes are associated with genetic and epigenetic deregulations, altered cellular signaling responses and aberrant interactions with the microenvironment. These alterations are constantly evolving as tumor cells face changing selective pressures induced by the cells themselves, the microenvironment and drug treatments. Tumors are also complex ecosystems where different, sometime heterogeneous, subclonal ...
Tópico(s): Bioinformatics and Genomic Networks
2014 - Springer Nature | Oncogene
Produção Nacional
Revisado por pares
Marilete Calegari Cardoso, Fernanda Kelly Barros Lago, Crislaine Dias dos Santos,
Este estudo é fruto de uma investigação de Iniciação Científica, em desenvolvimento, que analisa a potencialidade dos materiais não estruturados, na produção de brinquedos e brincadeiras para as crianças, em espaços públicos da cidade de Jequié- BA. Trata-se de uma pesquisa baseada em autores como Damasceno (2019), Tiriba (2010), Machado (2016), Piorski (2016) e outros. Assim, intencionou promover reflexões referentes ao papel das brincadeiras das crianças que utilizam os quatro elementos da natureza ...
Tópico(s): Environmental Sustainability and Education
2021 - Universidade Estadual do Suodeste da Bahia | Revista de Estudos em Educação e Diversidade - REED
Produção Nacional
Revisado por pares
Gabriel Soares de Almeida, Eduardo Duarte Marques, Francisco José da Silva, Claiton Piva Pinto, Emmanoel Vieira Silva-Filho,
... corrente de Bule com as concentrações médias dos elementos da Terra (UCC) revela intensa taxa de intemperismo das rochas- ...
Tópico(s): Radioactivity and Radon Measurements
2019 - Springer Science+Business Media | Journal of Sedimentary Environments
Produção Nacional
Revisado por pares
Gustavo Roberto dos Santos Leandro, Célia Alves de Souza,
... transportada no canal (cinco amostras) está relacionada aos elementos ambientais e uso da terra.Os sedimentos finos são transferidos para as feições ( ...
Tópico(s): Soil erosion and sediment transport
2012 - Instituto de Pesquisas Ambientais em Bacias Hidrográficas (IPABHi) | Ambiente e Agua - An Interdisciplinary Journal of Applied Science
Tópico(s): Superconducting Materials and Applications
2011 - | Aleph UCLA Undergraduate Research Journal for the Humanities and Social Sciences
Produção Nacional
Revisado por pares
Antônio Márcio Buainain, Júnior Ruiz Garcia,
... e no norte de Minas de Gerais, o elemento característico não é a falta de terra, mas sim a forte restrição hídrica. O Estado ...
Tópico(s): Agriculture, Land Use, Rural Development
2015 - Couffy-sur-Sarsonne | Confins
... político do MST de constituição das Comunas da Terra, como elemento de uma nova concepção de reforma agrária, pudemos ...
Tópico(s): Rural and Ethnic Education
2006 - | Agrária (São Paulo Online)
Produção Nacional
Revisado por pares
Ronaldo Severiano Berton, J. M. A. S. Valadares, Otávio Antônio de Camargo, Ondino Cleante Bataglia,
... sendo cortada, seca, pesada e analisada para os elementos Zn, Cu e Ni. Amostras de terra de cada tratamento foram retiradas e tiveram os ...
Tópico(s): Soil Management and Crop Yield
1997 - Sociedade Brasileira de Ciência do Solo | Revista Brasileira de Ciência do Solo
Matthew J. Mosquera, Sungwoong Kim, Rohan Bareja, Fang Zhou, Shuangyi Cai, Heng Pan, Muhammad Asad, M. Laura Martín, Michael Sigouros, Florencia P. Madorsky Rowdo, Sarah E. Ackermann, Jared Capuano, Jacob Bernheim, Cynthia Cheung, Ashley S. Doane, Nicholas J. Brady, Richa Singh, David S. Rickman, Varun V. Prabhu, Joshua E. Allen, Loredana Puca, Ahmet F. Coskun, Mark A. Rubin, Himisha Beltran, Juan Miguel Mosquera, Olivier Elemento, Ankur Singh,
Following treatment with androgen receptor (AR) pathway inhibitors, ≈20% of prostate cancer patients progress by shedding their AR-dependence. These tumors undergo epigenetic reprogramming turning castration-resistant prostate cancer adenocarcinoma (CRPC-Adeno) into neuroendocrine prostate cancer (CRPC-NEPC). No targeted therapies are available for CRPC-NEPCs, and there are minimal organoid models to discover new therapeutic targets against these aggressive tumors. Here, using a combination of patient ...
Tópico(s): Advanced Proteomics Techniques and Applications
2021 - | Advanced Materials
Mengying Sun, Fei Wang, Olivier Elemento, Jiayu Zhou,
In this work, we proposed a DDI detection method based on molecular structures using graph convolutional networks and deep sets. We proposed a more discriminative convolutional layer compared to conventional GCN and achieved permutation invariant prediction without losing the capability of capturing complicated interactions.
Tópico(s): Computational Drug Discovery Methods
2020 - Association for the Advancement of Artificial Intelligence | Proceedings of the AAAI Conference on Artificial Intelligence
Nikica Zaninović, Olivier Elemento, Zev Rosenwaks,
At its core, artificial intelligence (AI) is "a partnership between man and machine" (Ginni Rometty, IBM CEO). The embodiment of AI is a computer program that can learn to execute tasks involving forms of intelligence normally ascribed to humans. How well a computer will be able to emulate or exceed humans is the essential question driving AI technology. Already, AI is powering a variety of consumer products, from the Apple voice assistant Siri to product recommendations on Amazon, face recognition ...
Tópico(s): Autopsy Techniques and Outcomes
2019 - Elsevier BV | Fertility and Sterility
Neel S. Madhukar, Olivier Elemento, Gaurav Pandey,
A genetic interaction is a type of interaction where the effect of one gene is modified by the effect of one or several other genes. These interactions are important for delineating functional relationships among genes and their corresponding proteins, as well as elucidating complex biological processes and diseases. An important type of genetic interaction - synthetic sickness or synthetic lethality - involves two or more genes, where the loss of either gene alone has little impact on cell viability, ...
Tópico(s): Gene expression and cancer classification
2015 - Frontiers Media | Frontiers in Bioengineering and Biotechnology