Wiley Online Library
Produção Nacional
Revisado por pares
Marcelo Godoi, Andrielli Leitemberger, Lucas Martins Correa Böhs, Márcia V. Silveira, Jamal Rafique, Marcelo G. Montes D’Oca,
Tópico(s): Organoselenium and organotellurium chemistry
2019 - Springer Science+Business Media | Environmental Chemistry Letters
Produção Nacional
Revisado por pares
Rafael C. Brinkerhoff, Eduarda Santa-Helena, Paulo C. do Amaral, Diego da Costa Cabrera, Renata Fontes Ongaratto, P. M. de Oliveira, Caroline Da Ros Montes D’Oca, Carla Amorim Neves Gonçalves, Luiz Eduardo Maia Nery, Marcelo G. Montes D’Oca,
Polyhydroquinolines (PHQs) are the unsymmetrical Hantzsch derivatives of 1,4-dihydropyridines with several biological applications. In this work, new fatty 2- and 3-substituted PHQ derivatives from different fatty acids and fatty alcohol feedstocks were synthesized at good yields via a four-component reaction (4CR). The antioxidant activities of fatty PHQs were investigated using three different antioxidant methods. The experiments showed that the compounds derived from 2-nitrobenzaldehyde and fatty ...
Tópico(s): Chemical Synthesis and Reactions
2019 - Royal Society of Chemistry | RSC Advances
Produção Nacional
Revisado por pares
Franciele Saes de Oliveira, P. M. de Oliveira, Luana Machado Farias, Rafael C. Brinkerhoff, Rui Carlos M. Alves Sobrinho, Tamara M. Treptow, Caroline Da Ros Montes D’Oca, Marcelo Augusto Germani Marinho, Mariana Appel Hort, Ana Paula Horn, Dennis Russowsky, Marcelo G. Montes D’Oca,
Heterocyclic–fatty acid derivatives are a new class of compounds with a broad range of biological activities.
Tópico(s): Synthesis of heterocyclic compounds
2018 - Royal Society of Chemistry | MedChemComm
Produção Nacional
Revisado por pares
Diego da Costa Cabrera, Eduarda Santa-Helena, Heloisa P. Leal, Renata Rodrigues de Moura, Luiz Eduardo Maia Nery, Carla Amorim Neves Gonçalves, Dennis Russowsky, Marcelo G. Montes D’Oca,
Dihydropyridines (DHPs) obtained from Hantzsch multicomponent reactions are an important pharmaceutical class of compounds marketed as antihypertensive (e.g., nifedipine, nitrendipine, and amlodipine) drugs. This study synthesized new symmetrical and unsymmetrical long-chain fatty DHPs using multicomponent reactions under metal-free conditions with sulfamic acid as a catalyst. The DHPs were tested for antioxidant activity using three different methods. The insertion of a long chain into the DHP core ...
Tópico(s): Phenothiazines and Benzothiazines Synthesis and Activities
2018 - Elsevier BV | Bioorganic Chemistry
Produção Nacional
Revisado por pares
Rui Carlos M. Alves Sobrinho, P. M. de Oliveira, Caroline Da Ros Montes D’Oca, Dennis Russowsky, Marcelo G. Montes D’Oca,
In this work, an efficient and reusable pyrrolidinium ionic liquid (PyrrIL) catalysis system was developed and used in a Knoevenagel condensation reaction of long-chain aldehydes with several 1,3-dicarbonyl compounds.
Tópico(s): Oxidative Organic Chemistry Reactions
2017 - Royal Society of Chemistry | RSC Advances
Produção Nacional
Revisado por pares
Diego da Costa Cabrera, Sabrina B. Rosa, Franciele Saes de Oliveira, Marcelo Augusto Germani Marinho, Caroline Da Ros Montes D’Oca, Dennis Russowsky, Ana Paula Horn, Marcelo G. Montes D’Oca,
Synthesis and antiproliferative activity of novel hybrid 3-substituted polyhydroquinoline-fatty acids.
Tópico(s): Synthesis of heterocyclic compounds
2016 - Royal Society of Chemistry | MedChemComm
Produção Nacional
Revisado por pares
Tamara G.M. Treptow, Fabrício Figueiró, Elisa Helena Farias Jandrey, Ana Maria Oliveira Battastini, Christianne Gazzana Salbego, Juliana Bender Hoppe, Priscila S. Taborda, Sabrina B. Rosa, Luciana A. Piovesan, Caroline Da Ros Montes D’Oca, Dennis Russowsky, Marcelo G. Montes D’Oca,
We described the first synthesis of fatty acid 3,4-dihydropyrimidinones (DHPM-fatty acids) using the Biginelli multicomponent reaction. Antiproliferative activity on two glioma cell lines (C6 rat and U-138-MG human) was also reported. The novel DHPM-fatty acids reduced glioma cell viability relative to temozolomide. Hybrid oxo-monastrol-palmitic acid was the most potent, reducing U-138-MG human cell viability by ca. 50% at 10 μM. In addition, the DHPM-fatty acids showed a large safety range to neural ...
Tópico(s): Synthesis of heterocyclic compounds
2015 - Elsevier BV | European Journal of Medicinal Chemistry
Produção Nacional
Revisado por pares
Marieli O. Rodrigues, J. Cantos, Caroline Da Ros Montes D’Oca, Karina Lotz Soares, Tatiane S. Coelho, Luciana A. Piovesan, Dennis Russowsky, Pedro A. da Silva, Marcelo G. Montes D’Oca,
This work describes the synthesis of a series of fatty acid hydrazide derivatives of isoniazid (INH). The compounds were tested against Mycobacterium tuberculosis H37Rv (ATCC 27294) as well as INH-resistant (ATCC 35822 and 1896 HF) and rifampicin-resistant (ATCC 35338) M. tuberculosis strains. The fatty acid derivatives of INH showed high antimycobacterial potency against the studied strains, which is desirable for a pharmaceutical compound, suggesting that the increased lipophilicity of isoniazid plays ...
Tópico(s): Synthesis and biological activity
2013 - Elsevier BV | Bioorganic & Medicinal Chemistry
Produção Nacional
Revisado por pares
Rodrigo da Costa Duarte, Renata Fontes Ongaratto, Luciana A. Piovesan, Vânia Rodrigues de Lima, Valdir Soldi, Aloir A. Merlo, Marcelo G. Montes D’Oca,
This work reports the synthesis of new fatty N-acylamino acids and N-acylamino esters from the C16:0, C18:0, C18:1, and C18:1(OH) fatty acid families and demonstrates the activity of these compounds as organogel agents. Compounds were heated and dissolved in various solvents (n-hexane, toluene, and gasoline). Only saturated C16:0 and C18:0 derived from alanine were able to form gels in toluene, and saturated C16:0 derived from phenylalanine showed gelation in n-hexane. This is the first evidence ...
Tópico(s): Polydiacetylene-based materials and applications
2012 - Elsevier BV | Tetrahedron Letters
William A. Tiller, Walter E. Dibble, G. Orlando, Andrea Migli, G. Raiteri, J. Oca,
Objectives: To demonstrate information entanglement between separated sites of a single experimental system over distances of 5,000–6,000 miles and (2) to provide experimental ΔpH(t)-data, for these various sites that illustrates the information entanglement characteristic of this particular type of measurement. Such information entanglement has profound implications for distant healing. Design: The same as Part I but with two additional experimental sites, 5000–6000 miles distant from any other ...
Tópico(s): Metabolism and Genetic Disorders
2005 - Mary Ann Liebert, Inc. | The Journal of Alternative and Complementary Medicine
Produção Nacional
Revisado por pares
Daniela M. Tomazela, Luiz Alberto Beraldo de Moraes, Ronaldo A. Pilli, Marcos N. Eberlin, Marcelo G. M. D'Oca,
The intrinsic gas-phase reactivity of cyclic N-acyliminium ions in Mannich-type reactions with the parent enol silane, vinyloxytrimethylsilane, has been investigated by double- and triple-stage pentaquadrupole mass spectrometric experiments. Remarkably distinct reactivities are observed for cyclic N-acyliminium ions bearing either endocyclic or exocyclic carbonyl groups. NH-Acyliminium ions with endocyclic carbonyl groups locked in s-trans forms participate in a novel tandem N-acyliminium ion reaction: ...
Tópico(s): Advanced Chemical Physics Studies
2002 - American Chemical Society | The Journal of Organic Chemistry
Produção Nacional
Revisado por pares
Rafael C. Brinkerhoff, Hernan F. Tarazona, P. M. de Oliveira, Darlene C. Flores, Caroline Da Ros Montes D’Oca, Dennis Russowsky, Marcelo G. Montes D’Oca,
β-Ketoesters are valuable building blocks for the synthesis of compounds with different biological activities.
Tópico(s): Chemical Synthesis and Analysis
2014 - Royal Society of Chemistry | RSC Advances
Bruce Small, Philip H. Brown, Oscar Montes de Oca Munguia,
This study provides empirical evidence of the link between outlook and practice among farmers, foresters, and growers in New Zealand. Specifically, we use a large, nationally representative survey to assess how foci on production and environmental outcomes influence the adoption of six good management practices aimed at increasing agricultural sustainability. We then show that while environmentally oriented and production-oriented decision-makers are statistically more prepared to take risks, all ...
Tópico(s): Animal Behavior and Welfare Studies
2015 - Taylor & Francis | International Journal of Agricultural Sustainability
Ariel Gutiérrez Valencia, Roberto Montes de Oca García,
La dinámica de los cambios mundiales a los que se enfrentan los sistemas educativos de nivel superior hoy en día auspiciados por los nuevos paradigmas mundiales: Globalización, regionalización, revolución científica-tecnológica y sociedad del conocimiento, exigen de unnuevo perfil para el profesional universitario del siglo XXI, que se caracteriza por el dominioy el desarrollo de mayores competencias y destrezas, entre las que destacan las capacidades lectoras vistas como un valor estratégico agregado ...
Tópico(s): Educational Innovations and Technology
2004 - Organization of Ibero-American States | Revista Iberoamericana de Educación
Produção Nacional
Revisado por pares
H. D. Fontecha-Tarazona, Rafael C. Brinkerhoff, P. M. de Oliveira, Sabrina B. Rosa, Darlene C. Flores, Caroline Da Ros Montes D’Oca, Dennis Russowsky, Marcelo G. Montes D’Oca,
Multicomponent reactions as methods for green synthesis are important pathways for obtaining pharmacological compounds.
Tópico(s): Chemical Synthesis and Reactions
2015 - Royal Society of Chemistry | RSC Advances
Produção Nacional
Revisado por pares
Carolina Rosa Lopes, Caroline Da Ros Montes D’Oca, Rodrigo da Costa Duarte, Márcia H. S. Kurz, Ednei Gilberto Prímel, Rosilene Maria Clementin, Joaquín Ariel Morón Villarreyes, Marcelo G. Montes D’Oca,
ACIDS AMIDES FROM AMINOLYSIS OF FAMES.Recent biochemical and pharmacological studies have led to the characterization of different fatty acid amides as a new family of biologically active lipids.Here, we describe the synthesis of new amides from C16:0, 18:0, 18:1 and 18:1, OH fatty acids (FFA) families with cyclic and acyclic amines and demonstrate for the first time that these compounds produce citotoxic effects.Application of this method to the synthesis of fatty acid amides was performed using ...
Tópico(s): Enzyme Catalysis and Immobilization
2010 - Brazilian Chemical Society | Química Nova
Produção Nacional
Revisado por pares
Clarissa H. Rosa, Maura L. Bruckchem Peixoto, Gilber R. Rosa, Benhur Godoi, Fábio Z. Galetto, Marcelo G. Montes D’Oca, Marcelo Godoi,
Herein, we described a new method for the preparation of thioethers through hydrothiolation of alkenes and alkynes, using sulfamic acid as a reusable catalyst. Generally, this new methodology afforded the desired products in very good yields, under metal and solvent-free conditions. Furthermore, the catalyst was easily recovered and reused for further catalytic reactions without loss of activity.
Tópico(s): Organoselenium and organotellurium chemistry
2017 - Elsevier BV | Tetrahedron Letters
Produção Nacional
Revisado por pares
Marla N. Godoi, Hellen S. Costenaro, Eliane Kramer, Paola S. Machado, Marcelo G. Montes D’Oca, Dennis Russowsky,
NEW BIGINELLI COMPOUNDS PROMOTED BY In(OTf) 3 .In this paper, we describe a practical route for the synthesis of Biginelli compounds using In(OTf) 3 .To study the generality of this catalyst, several examples using aromatic aldehydes, 1,3-dicarbonyl compounds, urea, and thiourea were investigated.The present procedure provides an efficient modification of the classical Biginelli reaction, namely short reaction times and simple work-up, that not only preserves the simplicity of the original protocol ...
Tópico(s): Synthesis and biological activity
2005 - Brazilian Chemical Society | Química Nova
Evgueni Gordienko, Enrique Lemus-Rodríguez, Raúl Montes-de-Oca,
Tópico(s): Statistical Methods and Inference
2007 - Springer Science+Business Media | Mathematical Methods of Operations Research
Mònica Riva, Alberto Guadagnini, Aronne Dell’Oca,
Coastal aquifers are affected by seawater intrusion (SWI) on a worldwide scale. The Henry’s problem has been often used as a benchmark to analyze this phenomenon. Here, we investigate the way an incomplete knowledge of the system properties impacts the assessment of global quantities (GQs) describing key characteristics of the saltwater wedge in the dispersive Henry’s problem. We recast the problem in dimensionless form and consider four dimensionless quantities characterizing the SWI process, i.e., ...
Tópico(s): Groundwater and Isotope Geochemistry
2014 - Elsevier BV | Advances in Water Resources
Produção Nacional
Revisado por pares
Dennis Russowsky, Fabrício Abella Lopes, Verónica Silva, Karen Canto, Marcelo G. Montes D’Oca, Marla N. Godoi,
The ability of SnCl2.2H2O as catalyst to promote the Biginelli three-component condensation reaction from a diversity of aromatic aldehydes, ethyl acetoacetate and urea or thiourea is described. The reaction was carried out in acetonitrile or ethanol as solvents in neutral media and represents an improvement of the classical Biginelli protocol and an advantage in comparison with FeCl3.6H2O, NiCl2.6H2O and CoCl2.6H2O which were used with HCl as co-catalyst. The synthesis of 3,4-dihydropyrimidinones ...
Tópico(s): Microwave-Assisted Synthesis and Applications
2004 - Brazilian Chemical Society | Journal of the Brazilian Chemical Society
Onésimo Hernández–Lerma, Raúl Montes-de-Oca, Rolando Cavazos–Cadena,
Tópico(s): Stochastic processes and financial applications
1991 - Springer Science+Business Media | Annals of Operations Research
Ingrid Masaló Llorà, Òscar Guadayol, Francesc Peters, Joan Oca,
Sedimentation and resuspension processes of aquaculture biosolids (non-ingested feed and faeces) are analysed using vertically oscillating grids as a source of turbulence in fluid tanks. An oscillating grid system consists of a container in which a grid is stirred vertically generating a well-known turbulent field that is function of amplitude and frequency of oscillation, distance between grid and measurement point, and mesh spacing of the grid. The grid used in this study had a mesh spacing of ...
Tópico(s): Marine Bivalve and Aquaculture Studies
2008 - Elsevier BV | Aquacultural Engineering
Maurizio Marrale, Maria Brai, G. Gennaro, A. Bartolotta, Maria Cristina D’Oca,
Many efforts have been made to develop neutron capture therapy (NCT) for cancer treatment. Among the challenges in using NCT is the characterization of the features of the mixed radiation field and of its components. In this study, we examined the enhancement of the ESR response of pellets of alanine and ammonium tartrate with gadolinium oxide exposed to a thermal neutron beam. In particular, the ESR response of these dosimeters as a function of the gadolinium content inside the dosimeter was analyzed. ...
Tópico(s): Radiation Detection and Scintillator Technologies
2008 - Radiation Research Society | Radiation Research
Maurizio Marrale, G. Gennaro, M. Brai, S. Basile, A. Bartolotta, Maria Cristina D’Oca,
Electron spin resonance solid state dosimetry with alanine and ammonium tartrate pellets is a valuable tool in both medical and industrial applications when dealing with photon and charged particle beams. Its use in neutron beams is limited by the low nuclear cross section values of atoms in the pellets. Addition of boron (10B) or gadolinium (Gd2O3), known to have high neutron capture cross sections, has been proposed to improve neutron sensitivity. In this paper we present the results of an experimental ...
Tópico(s): Radiation Detection and Scintillator Technologies
2007 - Elsevier BV | Radiation Measurements
M. Brai, G. Gennaro, Maurizio Marrale, Luigi Tranchina, A. Bartolotta, Maria Cristina D’Oca,
This work presents experimental results regarding a new ammonium tartrate blend for ESR dosimetry, with a higher sensitivity and a lower lowest detectable dose (LDD) to Co60 γ-rays than the recently used pure ammonium tartrate. The blend composed by ammonium tartrate and gadolinium-oxide (Gd2O3) shows a greater sensitivity (∼2 times) and a smaller LDD than ammonium tartrate. The increased sensitivity was mainly attributed to the great atomic number (Z=64) of gadolinium, that increases the effective atomic ...
Tópico(s): Thermal and Kinetic Analysis
2007 - Elsevier BV | Radiation Measurements
Maurizio Marrale, Maria Brai, Alessandro Triolo, A. Bartolotta, Maria Cristina D’Oca,
In this paper we present an investigation of the electron spin resonance (ESR) line shape of ammonium tartrate (AT) dosimeters exposed to radiation with different linear energy transfer (LET). We exposed our dosimeters to gamma-ray photons ((60)Co), 7 MeV and 14 MeV initial energy electrons, and 19.3 MeV initial energy protons. The differences in the power saturation behavior of ESR spectra of AT irradiated with photons, electrons and protons could be correlated to the effective LET of the radiation ...
Tópico(s): Nuclear Physics and Applications
2006 - Radiation Research Society | Radiation Research
M. Brai, G. Gennaro, Maurizio Marrale, A. Bartolotta, Maria Cristina D’Oca,
Tópico(s): Nuclear Physics and Applications
2006 - Elsevier BV | Applied Radiation and Isotopes
F. Trompier, P. Fattibene, D.D. Tikunov, A. Bartolotta, Alessandra Carosi, Maria Cristina D’Oca,
Journal Article EPR dosimetry in a mixed neutron and gamma radiation field Get access F. Trompier, F. Trompier *Corresponding author: francois.trompier@irsn.fr Search for other works by this author on: Oxford Academic PubMed Google Scholar P. Fattibene, P. Fattibene Search for other works by this author on: Oxford Academic PubMed Google Scholar D. Tikunov, D. Tikunov Search for other works by this author on: Oxford Academic PubMed Google Scholar A. Bartolotta, A. Bartolotta Search for other works ...
Tópico(s): Luminescence Properties of Advanced Materials
2004 - Oxford University Press | Radiation Protection Dosimetry